[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr2:23,453,834-25,889,403

Best TWAS P=9.94e-23 · Best GWAS P=2.77e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-8.9	9.8	9.9e-23	-0.77	0.06	0.93	TRUE
28	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-9.2	-9.3	1.9e-20	0.76	0.05	0.95	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-9.3	8.6	7.4e-18	-0.80	0.02	0.98	TRUE
25	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	7.4	-8.3	8.6e-17	0.14	0.04	0.92	TRUE
13	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	-7.7	-7.4	1.1e-13	0.54	0.21	0.78	TRUE
9	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-6.1	-7.3	2.0e-13	0.31	0.07	0.13	TRUE
35	The Cancer Genome Atlas	Glioblastoma Multiforme	ADCY3	0.36	0.14	enet	7	0.13	8.9e-05	-6.5	7.1	1.6e-12	-0.32	0.04	0.18	TRUE
18	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-1.9	-6.6	3.4e-11	0.23	0.51	0.03	TRUE
8	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	6.4	-6.5	9.4e-11	0.39	0.98	0.00	TRUE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCOA1	0.08	0.07	blup	77	0.05	5.8e-04	2.6	-5.8	5.0e-09	0.21	0.10	0.63	TRUE
32	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	-9.2	5.3	9.8e-08	-0.47	0.02	0.98	TRUE
15	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-8.9	9.7	2.4e-22	-0.83	0.04	0.90	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-9.2	9.7	4.1e-22	-0.80	0.04	0.96	FALSE
21	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-7.7	9.7	5.0e-22	-0.81	0.04	0.96	FALSE
30	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-8.7	-9.0	2.1e-19	0.77	0.08	0.92	FALSE
22	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	-7.7	8.8	1.2e-18	-0.71	0.06	0.92	FALSE
17	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-6.2	-8.8	1.4e-18	0.48	0.08	0.11	FALSE
27	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-8.7	-8.7	2.9e-18	0.69	0.12	0.88	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-6.7	8.7	4.6e-18	-0.77	0.05	0.90	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-8.9	-8.5	1.4e-17	0.75	0.05	0.94	FALSE
11	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	-7.7	-8.4	2.9e-17	0.63	0.78	0.22	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	-5.7	8.0	9.7e-16	-0.48	0.65	0.30	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	-4.6	7.7	2.1e-14	-0.52	0.48	0.24	FALSE
29	GTEx	Whole Blood	UBXN2A	0.17	0.07	lasso	8	0.09	2.1e-08	-4.4	-7.4	1.3e-13	0.12	0.03	0.97	FALSE
16	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-6.6	-7.3	3.5e-13	0.12	0.07	0.72	FALSE
19	GTEx	Lung	UBXN2A	0.09	0.06	enet	7	0.07	6.1e-06	-4.4	-6.6	3.8e-11	0.11	0.26	0.73	FALSE
12	GTEx	Artery Tibial	UBXN2A	0.12	0.06	enet	24	0.09	1.5e-07	-4.0	-6.4	1.8e-10	0.12	0.78	0.22	FALSE
24	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-6.6	-6.4	2.0e-10	0.15	0.03	0.90	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY3	0.08	0.03	enet	16	0.03	1.5e-04	-5.7	6.3	2.6e-10	-0.10	0.03	0.07	FALSE
4	GTEx	Adipose Subcutaneous	UBXN2A	0.06	0.04	lasso	5	0.04	5.2e-04	-6.6	-6.1	9.6e-10	0.09	0.26	0.72	FALSE
7	GTEx	Adipose Visceral Omentum	UBXN2A	0.10	0.08	enet	29	0.03	9.8e-03	-6.6	-6.0	1.9e-09	0.10	0.08	0.89	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADCY3	0.06	0.01	enet	9	0.02	1.0e-03	-5.6	6.0	2.6e-09	-0.23	0.06	0.04	FALSE
23	GTEx	Skin Sun Exposed Lower leg	UBXN2A	0.08	0.04	enet	17	0.03	1.3e-03	-6.6	-5.9	3.1e-09	0.11	0.57	0.33	FALSE
5	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	-2.3	-5.9	3.6e-09	0.71	0.04	0.88	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBXN2A	0.03	0.02	blup	46	0.03	5.7e-04	-4.4	-5.8	6.5e-09	0.09	0.26	0.40	FALSE
20	GTEx	Muscle Skeletal	UBXN2A	0.10	0.04	lasso	7	0.03	5.5e-04	-4.4	-5.8	8.2e-09	0.09	0.25	0.75	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	5.7	5.7	9.9e-09	-0.71	0.55	0.06	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	-2.6	5.6	1.9e-08	-0.52	0.53	0.38	FALSE
33	YFS	Blood	CENPO	0.09	0.06	lasso	6	0.07	6.7e-21	-5.2	5.5	3.0e-08	-0.25	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFR3B	0.26	0.01	lasso	4	0.05	3.8e-03	-6.2	-5.5	3.1e-08	0.41	0.03	0.15	FALSE
6	GTEx	Adipose Visceral Omentum	NCOA1	0.11	0.02	enet	17	0.02	2.1e-02	-5.1	-5.5	3.9e-08	0.36	0.17	0.10	FALSE
26	GTEx	Stomach	UBXN2A	0.13	0.14	enet	5	0.14	3.6e-07	-4.0	-5.4	5.5e-08	0.09	0.58	0.31	FALSE
10	GTEx	Artery Aorta	UBXN2A	0.20	0.09	lasso	6	0.08	4.1e-05	-4.0	-5.2	2.1e-07	0.10	0.79	0.21	FALSE