[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) :

chr6:108,994,161-110,843,638

Best TWAS P=5.95e-16 · Best GWAS P=7.43e-18 conditioned to 0.000184

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SMPD2 0.14 0.10 lasso 10 0.12 2.3e-10 -6.6 -6.1 1.0e-09 0.16 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous AK9 0.12 0.09 lasso 7 0.10 2.1e-08 -6.9 6.5 5.6e-11 -0.13 0.14 0.86 FALSE
3 GTEx Adipose Visceral Omentum AK9 0.10 0.02 enet 27 0.04 2.7e-03 -6.4 6.6 4.4e-11 -0.18 0.12 0.85 FALSE
4 GTEx Adipose Visceral Omentum RP11-425D10.10 0.16 0.10 lasso 6 0.06 7.2e-04 -6.9 -7.0 3.4e-12 0.16 0.62 0.04 FALSE
5 GTEx Artery Aorta SMPD2 0.10 0.04 enet 11 0.03 1.5e-02 -6.9 -7.2 4.7e-13 0.14 0.63 0.09 FALSE
6 GTEx Artery Aorta AK9 0.16 0.14 enet 32 0.14 3.7e-08 3.6 5.8 5.2e-09 -0.12 0.31 0.69 FALSE
7 GTEx Artery Aorta RP11-425D10.10 0.12 0.06 lasso 4 0.09 1.4e-05 -6.9 -5.7 1.2e-08 0.11 0.82 0.09 FALSE
8 GTEx Artery Coronary SMPD2 0.11 0.09 lasso 4 0.07 1.9e-03 -4.7 -5.5 3.2e-08 0.15 0.36 0.04 FALSE
9 GTEx Artery Coronary AK9 0.27 0.26 enet 18 0.28 5.2e-10 3.5 5.4 5.9e-08 -0.10 0.55 0.44 FALSE
10 GTEx Artery Tibial MICAL1 0.08 0.02 lasso 3 0.01 6.5e-02 -7.6 -7.6 3.3e-14 0.13 0.40 0.12 FALSE
11 GTEx Artery Tibial AK9 0.13 0.12 enet 18 0.13 3.5e-10 -6.8 6.9 5.9e-12 -0.14 0.28 0.72 FALSE
12 GTEx Artery Tibial RP11-425D10.10 0.10 0.10 lasso 4 0.10 3.9e-08 -7.5 -7.6 2.8e-14 0.10 0.81 0.19 FALSE
13 GTEx Brain Caudate basal ganglia AK9 0.20 0.16 enet 16 0.17 1.1e-05 -6.3 6.5 6.9e-11 -0.16 0.14 0.80 FALSE
14 GTEx Brain Cerebellar Hemisphere AK9 0.24 0.17 lasso 3 0.11 1.0e-03 -6.9 6.7 2.6e-11 -0.13 0.17 0.50 FALSE
15 GTEx Brain Cortex AK9 0.21 0.03 enet 29 0.16 3.2e-05 -6.3 5.7 1.5e-08 -0.14 0.10 0.84 FALSE
16 GTEx Brain Nucleus accumbens basal ganglia AK9 0.28 0.02 enet 22 0.09 1.8e-03 -6.3 5.2 1.8e-07 -0.12 0.17 0.32 FALSE
17 GTEx Breast Mammary Tissue SMPD2 0.14 0.09 lasso 5 0.05 2.2e-03 -6.6 -6.6 3.9e-11 0.12 0.49 0.03 FALSE
18 GTEx Breast Mammary Tissue AK9 0.17 0.13 enet 19 0.13 4.0e-07 -6.9 5.9 4.1e-09 -0.11 0.02 0.98 FALSE
19 GTEx Breast Mammary Tissue RP11-425D10.10 0.12 0.12 lasso 1 0.08 5.1e-05 -6.9 -6.9 6.9e-12 0.13 0.87 0.07 FALSE
20 GTEx Breast Mammary Tissue (Male) SMPD2 0.14 0.04 lasso 4 0.07 9.4e-03 3.5 -5.8 8.5e-09 0.11 0.15 0.06 FALSE
21 GTEx Breast Mammary Tissue (Male) AK9 0.10 0.03 lasso 3 -0.01 5.4e-01 -6.9 7.3 3.1e-13 -0.12 0.03 0.55 FALSE
22 GTEx Breast Mammary Tissue (Female) AK9 0.12 0.15 lasso 1 0.12 1.9e-04 -6.9 6.9 6.9e-12 -0.13 0.06 0.64 FALSE
23 GTEx Breast Mammary Tissue (Female) RP11-425D10.10 0.14 0.04 lasso 10 0.02 6.5e-02 -7.6 -7.5 5.3e-14 0.16 0.06 0.05 FALSE
24 GTEx Cells EBV-transformed lymphocytes AK9 0.32 0.13 lasso 7 0.25 1.2e-08 -6.3 5.6 1.7e-08 -0.12 0.27 0.72 FALSE
25 GTEx Cells Transformed fibroblasts SMPD2 0.20 0.13 lasso 9 0.15 3.1e-11 -6.6 -6.5 9.5e-11 0.13 1.00 0.00 FALSE
26 GTEx Colon Sigmoid FIG4 0.17 0.11 lasso 9 0.03 3.7e-02 -7.6 7.0 1.9e-12 -0.11 0.02 0.91 FALSE
27 GTEx Colon Sigmoid AK9 0.13 0.06 enet 32 0.13 3.1e-05 -7.6 6.3 3.8e-10 -0.12 0.04 0.92 FALSE
28 GTEx Colon Transverse SMPD2 0.19 0.25 lasso 5 0.24 1.1e-11 -6.6 -6.7 3.0e-11 0.13 0.99 0.01 FALSE
29 GTEx Colon Transverse RP11-425D10.10 0.12 0.13 enet 21 0.14 2.2e-07 -7.6 -7.4 1.4e-13 0.14 0.89 0.11 FALSE
30 GTEx Esophagus Gastroesophageal Junction SMPD2 0.11 0.06 lasso 6 0.06 4.1e-03 -4.7 -5.4 5.3e-08 0.15 0.36 0.05 FALSE
31 GTEx Esophagus Mucosa SMPD2 0.17 0.20 lasso 10 0.22 2.2e-14 -7.6 -7.6 3.8e-14 0.14 0.82 0.18 FALSE
32 GTEx Esophagus Mucosa AK9 0.11 0.06 lasso 13 0.04 6.0e-04 -6.3 6.6 3.9e-11 -0.14 0.04 0.96 FALSE
33 GTEx Esophagus Mucosa RP11-425D10.10 0.09 0.13 lasso 5 0.12 1.1e-08 -6.9 -6.8 8.9e-12 0.13 0.98 0.02 FALSE
34 GTEx Esophagus Muscularis FIG4 0.14 0.02 enet 10 0.03 7.8e-03 -6.3 5.2 1.5e-07 -0.09 0.12 0.67 FALSE
35 GTEx Esophagus Muscularis CD164 0.04 0.02 enet 6 0.01 1.0e-01 -6.4 -6.8 1.4e-11 0.14 0.26 0.04 FALSE
36 GTEx Esophagus Muscularis SMPD2 0.10 0.05 enet 13 0.05 2.9e-04 -5.6 -5.2 2.1e-07 0.11 0.36 0.03 FALSE
37 GTEx Heart Atrial Appendage RP11-425D10.10 0.12 0.11 lasso 5 0.07 4.0e-04 -6.9 -6.4 1.5e-10 0.09 0.69 0.05 FALSE
38 GTEx Heart Left Ventricle AK9 0.17 0.04 enet 11 0.13 2.3e-07 -6.3 5.6 2.1e-08 -0.09 0.22 0.77 FALSE
39 GTEx Heart Left Ventricle RP11-425D10.10 0.13 0.04 enet 34 0.03 9.2e-03 -6.9 -6.2 7.9e-10 0.09 0.35 0.08 FALSE
40 GTEx Lung SMPD2 0.10 0.12 lasso 2 0.10 7.5e-08 -6.6 -6.6 4.7e-11 0.13 1.00 0.00 FALSE
41 GTEx Lung RP11-425D10.10 0.10 0.08 enet 24 0.07 6.4e-06 -7.6 -6.5 6.9e-11 0.15 0.85 0.14 FALSE
42 GTEx Muscle Skeletal AK9 0.08 0.02 lasso 6 0.03 4.3e-04 3.5 5.3 1.4e-07 -0.11 0.15 0.83 FALSE
43 GTEx Nerve Tibial SMPD2 0.12 0.08 lasso 4 0.08 3.6e-06 -5.0 -5.6 2.1e-08 0.14 0.96 0.00 TRUE
44 GTEx Nerve Tibial AK9 0.18 0.15 enet 26 0.18 1.5e-12 -6.9 5.4 5.2e-08 -0.11 0.41 0.59 FALSE
45 GTEx Ovary RP11-425D10.10 0.15 0.10 lasso 5 0.02 9.0e-02 -6.9 -7.2 7.2e-13 0.13 0.21 0.08 FALSE
46 GTEx Pancreas SMPD2 0.09 0.07 lasso 3 0.08 2.1e-04 -6.6 -6.6 3.5e-11 0.13 0.37 0.04 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic SMPD2 0.27 0.15 lasso 10 0.17 1.6e-09 -6.9 -7.0 2.8e-12 0.14 0.98 0.02 FALSE
48 GTEx Skin Not Sun Exposed Suprapubic RP11-425D10.10 0.20 0.27 lasso 5 0.27 5.5e-15 -6.8 -6.9 3.8e-12 0.13 0.99 0.01 FALSE
49 GTEx Skin Sun Exposed Lower leg SMPD2 0.19 0.19 lasso 12 0.24 1.6e-19 -6.3 -7.1 9.4e-13 0.14 0.99 0.01 FALSE
50 GTEx Skin Sun Exposed Lower leg AK9 0.14 0.12 lasso 3 0.14 1.9e-11 -6.9 6.0 1.4e-09 -0.10 0.47 0.53 FALSE
51 GTEx Skin Sun Exposed Lower leg RP11-425D10.10 0.19 0.23 enet 18 0.23 3.4e-19 -6.8 -6.9 7.1e-12 0.15 1.00 0.00 FALSE
52 GTEx Small Intestine Terminal Ileum RP11-425D10.10 0.16 0.07 lasso 9 0.06 1.5e-02 -7.6 -7.0 3.0e-12 0.14 0.11 0.06 FALSE
53 GTEx Stomach RP11-425D10.10 0.25 0.10 lasso 6 0.09 3.0e-05 -7.3 -5.3 1.1e-07 -0.07 0.74 0.18 FALSE
54 GTEx Testis ZBTB24 0.11 0.11 lasso 4 0.10 4.9e-05 -6.9 6.7 2.7e-11 -0.14 0.22 0.70 FALSE
55 GTEx Testis SMPD2 0.28 0.18 lasso 7 0.17 7.6e-08 -6.6 -6.9 5.3e-12 0.13 0.96 0.03 FALSE
56 GTEx Thyroid AK9 0.11 0.08 enet 22 0.13 1.9e-10 -7.5 6.2 7.6e-10 -0.10 0.02 0.98 FALSE
57 GTEx Thyroid PPIL6 0.17 0.05 lasso 4 0.12 4.4e-09 -7.6 5.4 8.3e-08 -0.10 0.83 0.16 FALSE
58 GTEx Vagina RP11-425D10.10 0.42 0.22 lasso 19 0.17 9.0e-05 -6.9 -7.2 4.1e-13 0.13 0.50 0.08 FALSE
59 GTEx Whole Blood SMPD2 0.15 0.16 lasso 8 0.15 1.0e-13 -6.6 -6.5 9.5e-11 0.13 1.00 0.00 FALSE
60 GTEx Whole Blood RP11-425D10.10 0.04 0.03 enet 16 0.03 6.2e-04 -6.4 -6.9 5.0e-12 0.14 0.71 0.09 FALSE
61 METSIM Adipose AK9 0.05 0.03 lasso 6 0.02 1.0e-04 -6.9 7.1 1.6e-12 -0.12 0.02 0.98 FALSE
62 METSIM Adipose SMPD2 0.06 0.08 enet 14 0.08 2.0e-12 -6.6 -8.1 6.0e-16 0.31 0.99 0.01 TRUE
63 ROSMAP Brain Pre-frontal Cortex ZBTB24 0.03 0.00 blup 389 0.00 7.3e-02 -6.9 5.1 2.9e-07 -0.08 0.04 0.87 TRUE
64 ROSMAP Brain Pre-frontal Cortex SMPD2 0.12 0.10 lasso 5 0.09 1.3e-11 -6.6 -5.8 8.7e-09 0.12 1.00 0.00 FALSE
65 YFS Blood SMPD2 0.06 0.08 lasso 7 0.08 2.5e-24 -6.6 -6.8 7.7e-12 0.13 0.99 0.01 FALSE
66 The Cancer Genome Atlas Bladder Urothelial Carcinoma AKD1 0.08 0.06 blup 114 0.05 4.7e-05 -6.3 6.3 3.3e-10 -0.14 0.06 0.94 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma SMPD2 0.04 0.04 blup 43 0.05 3.9e-05 -7.6 -7.2 7.2e-13 0.13 0.01 0.98 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma AKD1 0.02 0.02 blup 122 0.03 1.0e-06 -6.3 5.8 5.4e-09 -0.11 0.04 0.96 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma SMPD2 0.04 0.07 lasso 4 0.07 8.8e-14 -6.6 -6.8 7.4e-12 0.14 0.14 0.86 FALSE
70 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SMPD2 0.07 0.08 blup 45 0.07 2.3e-04 -6.6 -7.3 3.0e-13 0.14 0.03 0.92 FALSE
71 The Cancer Genome Atlas Colon Adenocarcinoma SMPD2 0.17 0.14 lasso 4 0.14 2.3e-08 -6.1 -6.3 3.2e-10 0.14 0.35 0.65 FALSE
72 The Cancer Genome Atlas Esophageal Carcinoma SMPD2 0.12 0.09 blup 41 0.07 2.6e-03 -7.6 -7.7 1.6e-14 0.13 0.01 0.89 FALSE
73 The Cancer Genome Atlas Glioblastoma Multiforme SMPD2 0.18 0.08 enet 17 0.11 2.5e-04 -6.1 -5.8 6.5e-09 0.08 0.03 0.61 FALSE
74 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AKD1 0.07 0.06 blup 116 0.06 4.2e-07 -7.7 6.5 8.2e-11 -0.13 0.02 0.98 FALSE
75 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SMPD2 0.09 0.09 blup 42 0.10 2.1e-11 -7.3 -6.9 4.9e-12 0.14 0.07 0.93 FALSE
76 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AKD1 0.11 0.08 lasso 5 0.10 5.8e-11 -7.5 6.8 1.5e-11 -0.12 0.02 0.98 FALSE
77 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SMPD2 0.05 0.07 lasso 4 0.06 9.6e-08 -6.1 -6.9 6.4e-12 0.14 0.10 0.90 FALSE
78 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma AKD1 0.11 0.06 lasso 3 0.06 2.7e-04 -6.3 6.3 2.4e-10 -0.15 0.04 0.96 FALSE
79 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SMPD2 0.12 0.15 enet 6 0.14 3.8e-08 -6.6 -6.6 4.7e-11 0.13 0.23 0.77 FALSE
80 The Cancer Genome Atlas Brain Lower Grade Glioma AKD1 0.12 0.11 lasso 6 0.12 9.8e-14 -6.3 6.3 2.2e-10 -0.15 0.34 0.66 FALSE
81 The Cancer Genome Atlas Brain Lower Grade Glioma FIG4 0.05 0.02 blup 92 0.02 1.0e-03 -6.4 5.8 7.7e-09 -0.11 0.01 0.98 FALSE
82 The Cancer Genome Atlas Brain Lower Grade Glioma MICAL1 0.08 0.11 lasso 4 0.12 1.8e-13 -6.1 6.3 3.5e-10 -0.14 0.43 0.57 FALSE
83 The Cancer Genome Atlas Brain Lower Grade Glioma ZBTB24 0.04 0.05 lasso 4 0.04 7.8e-06 -7.5 7.3 2.3e-13 -0.13 0.01 0.99 FALSE
84 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PPIL6 0.07 0.03 blup 53 0.02 5.8e-02 -6.6 7.5 7.7e-14 -0.14 0.02 0.57 FALSE
85 The Cancer Genome Atlas Lung Adenocarcinoma AKD1 0.05 0.03 blup 122 0.04 1.3e-05 -6.6 7.0 2.8e-12 -0.14 0.02 0.98 FALSE
86 The Cancer Genome Atlas Lung Adenocarcinoma SMPD2 0.06 0.09 enet 11 0.08 4.7e-10 -6.6 -6.4 1.3e-10 0.13 0.12 0.88 FALSE
87 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AKD1 0.06 0.07 lasso 4 0.05 2.8e-06 -6.4 5.9 4.2e-09 -0.14 0.32 0.68 FALSE
88 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SMPD2 0.04 0.06 blup 45 0.06 8.9e-08 -7.3 -7.0 3.2e-12 0.14 0.05 0.95 FALSE
89 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma AKD1 0.04 0.03 blup 114 0.03 4.7e-03 -6.3 6.0 2.4e-09 -0.13 0.08 0.50 FALSE
90 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SMPD2 0.06 0.05 lasso 3 0.06 9.2e-05 -6.6 -5.9 4.7e-09 0.13 0.15 0.78 FALSE
91 The Cancer Genome Atlas Pancreatic Adenocarcinoma SMPD2 0.08 0.07 lasso 3 0.05 3.3e-03 -6.6 -6.6 4.7e-11 0.13 0.04 0.81 FALSE
92 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SMPD2 0.10 0.04 lasso 2 0.07 1.2e-03 -6.1 -6.6 5.3e-11 0.14 0.03 0.52 FALSE
93 The Cancer Genome Atlas Prostate Adenocarcinoma SMPD2 0.08 0.13 lasso 3 0.13 2.4e-13 -6.6 -6.6 4.5e-11 0.13 0.79 0.21 FALSE
94 The Cancer Genome Atlas Rectum Adenocarcinoma AKD1 0.26 0.12 blup 114 0.18 6.5e-05 3.2 5.6 2.2e-08 -0.12 0.12 0.62 FALSE
95 The Cancer Genome Atlas Rectum Adenocarcinoma SMPD2 0.13 0.08 lasso 2 0.06 1.5e-02 -6.6 -6.6 4.8e-11 0.13 0.01 0.37 FALSE
96 The Cancer Genome Atlas Stomach Adenocarcinoma AKD1 0.03 0.03 blup 121 0.02 6.3e-03 -7.6 6.1 1.2e-09 -0.12 0.02 0.84 FALSE
97 The Cancer Genome Atlas Stomach Adenocarcinoma SMPD2 0.07 0.07 blup 44 0.08 3.4e-06 -7.5 -7.2 5.4e-13 0.13 0.02 0.98 FALSE
98 The Cancer Genome Atlas Testicular Germ Cell Tumors SMPD2 0.23 0.13 lasso 5 0.17 1.4e-06 -6.8 -6.8 1.3e-11 0.08 0.01 0.98 FALSE
99 The Cancer Genome Atlas Thyroid Carcinoma AKD1 0.24 0.18 enet 21 0.26 2.5e-25 -6.3 6.0 2.1e-09 -0.11 0.03 0.97 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma CD164 0.03 0.01 blup 49 0.01 2.1e-02 -6.6 -6.0 2.7e-09 0.13 0.03 0.64 FALSE
101 The Cancer Genome Atlas Thyroid Carcinoma SMPD2 0.15 0.17 enet 14 0.18 9.4e-18 -6.6 -6.5 6.3e-11 0.14 0.28 0.72 FALSE