Best TWAS P=1.38e-10 · Best GWAS P=4.72e-10 conditioned to 0.00796
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AGBL2 | 0.03 | 0.02 | enet | 7 | 0.03 | 7.9e-05 | -5.3 | -5.5 | 3.3e-08 | 0.91 | 0.04 | 0.96 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PTPRJ | 0.06 | 0.04 | lasso | 4 | 0.05 | 7.6e-07 | -5.7 | -6.2 | 7.7e-10 | 0.85 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | RP11-750H9.5 | 0.17 | 0.25 | lasso | 6 | 0.21 | 3.5e-06 | 5.2 | -5.2 | 2.1e-07 | 0.31 | 0.39 | 0.15 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | ACP2 | 0.03 | 0.00 | lasso | 1 | 0.02 | 1.0e-01 | -6.1 | 6.1 | 1.0e-09 | -1.00 | 0.02 | 0.23 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | ACP2 | 0.17 | 0.03 | lasso | 6 | 0.03 | 4.2e-02 | -3.0 | 6.4 | 1.4e-10 | -0.66 | 0.08 | 0.79 | TRUE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | NUP160 | 0.18 | 0.02 | enet | 18 | 0.11 | 7.1e-05 | 2.6 | -5.5 | 4.3e-08 | 0.28 | 0.26 | 0.08 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ACP2 | 0.07 | 0.04 | enet | 11 | 0.04 | 6.2e-04 | -5.3 | 5.5 | 3.7e-08 | -0.75 | 0.04 | 0.95 | FALSE |
| 8 | GTEx | Muscle Skeletal | FNBP4 | 0.05 | 0.03 | lasso | 5 | 0.04 | 5.0e-05 | -5.4 | -6.0 | 2.5e-09 | 0.79 | 0.09 | 0.86 | FALSE |
| 9 | GTEx | Nerve Tibial | CELF1 | 0.08 | 0.02 | enet | 15 | 0.06 | 4.3e-05 | 4.6 | -5.2 | 1.7e-07 | 0.28 | 0.18 | 0.19 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | SLC39A13 | 0.07 | 0.11 | lasso | 2 | 0.10 | 5.2e-06 | -5.4 | -5.4 | 6.7e-08 | 0.94 | 0.12 | 0.69 | FALSE |
| 11 | METSIM | Adipose | NR1H3 | 0.03 | 0.03 | lasso | 6 | 0.04 | 4.7e-06 | 5.0 | -6.1 | 8.3e-10 | 0.45 | 0.17 | 0.77 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSMC3 | 0.09 | 0.05 | blup | 39 | 0.05 | 1.0e-03 | 5.2 | -5.2 | 2.2e-07 | 0.37 | 0.06 | 0.37 | FALSE |