Best TWAS P=7.24e-09 · Best GWAS P=7.14e-10 conditioned to 0.000303
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | ARRB2 | 0.29 | 0.08 | enet | 14 | 0.19 | 1.0e-06 | 4.5 | 5.2 | 2.4e-07 | 0.02 | 0.06 | 0.87 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ANKFY1 | 0.10 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | 5.5 | -5.8 | 7.2e-09 | 0.61 | 0.12 | 0.82 | TRUE |
| 3 | GTEx | Whole Blood | ARRB2 | 0.10 | 0.12 | lasso | 1 | 0.12 | 8.2e-11 | 5.2 | 5.2 | 2.4e-07 | 0.04 | 0.00 | 0.99 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ZZEF1 | 0.07 | 0.06 | lasso | 5 | 0.06 | 8.1e-08 | 5.6 | 5.5 | 3.3e-08 | -0.51 | 0.11 | 0.89 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ANKFY1 | 0.05 | 0.03 | enet | 11 | 0.02 | 1.2e-03 | 5.0 | 5.3 | 1.3e-07 | -0.44 | 0.16 | 0.59 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | ATP2A3 | 0.09 | 0.08 | blup | 67 | 0.07 | 1.1e-04 | 5.2 | -5.1 | 3.0e-07 | 0.70 | 0.02 | 0.89 | FALSE |