Hub : Genes

ATP2A3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.135	0.0580	1.3e-03	0.155	NA	0.101	NA	0.122	7.5e-08	NA	1.6e-05	NA	2.1e-06
2	GTEx	Lung	0.280	0.0529	4.0e-07	0.102	NA	0.123	NA	0.149	3.1e-08	NA	1.2e-09	NA	1.8e-11
3	ROSMAP	Brain Pre-frontal Cortex	0.125	0.0418	1.6e-03	0.051	0.014	0.039	0.04	0.042	3.9e-07	0.00610	8.5e-06	5.7e-06	3.2e-06
4	TCGA	Colon Adenocarcinoma	0.089	0.0400	4.4e-03	0.076	0.067	0.064	NA	0.065	3.6e-05	0.00011	1.5e-04	NA	1.3e-04
5	TCGA	Skin Cutaneous Melanoma	0.245	0.1000	9.5e-03	-0.011	0.014	-0.003	NA	-0.006	9.7e-01	0.13000	3.9e-01	NA	5.0e-01
6	TCGA	Testicular Germ Cell Tumors	0.316	0.1120	5.3e-03	0.001	0.009	0.055	NA	0.025	2.9e-01	0.15000	5.1e-03	NA	4.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	3.8	-1.9	0.2	-1.3	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.3	-0.9	1.2	-0.5	0.0	0.0	0.0
Depressed Affect (Nagel 2018)	0.5	1.0	2.8	1.4	0.4	0.1	1.7	-0.3	1.1
Depression (Nagel 2018)	1.2	1.8	9.5	0.5	-0.2	0.8	3.1	0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	-1.3	-0.8	-1.1	-0.5	-1.1	-1.2
Neuroticism (Nagel 2018)	0.8	1.9	7.0	1.6	0.2	-0.1	2.6	-0.2	1.3
Schizophrenia (2018)	0.2	0.4	1.7	0.4	1.3	0.5	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.6	0.8	4.2	2.1	-0.1	0.6	0.0	0.0	0.0
Worry (Nagel 2018)	1.1	2.3	5.3	0.1	1.7	0.8	2.1	0.4	2.3
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	0.6	0.5	0.4	0.0	-0.0	1.1
Alzheimer’s Disease (in father)	2.1	2.3	4.1	-1.8	0.7	-1.6	-2.0	1.7	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	1.0	0.0	-0.2	-1.0	-0.1	0.0	0.5
Crohns Disease (2017)	0.4	0.9	1.8	1.3	-0.9	-1.1	-0.7	-1.0	-0.2
Irritable Bowel Disease (IBD)	0.3	0.8	3.3	1.8	-0.6	0.0	0.5	-0.9	-0.2
Ulcerative Colitis (UC)	0.5	0.9	2.6	1.6	-0.9	0.5	0.9	-0.8	-0.6
Major Depression (MDD)	0.4	0.5	1.8	1.3	-1.0	0.3	0.0	0.0	0.0
Reaction Time	1.2	2.2	4.2	-1.3	1.6	1.2	-1.3	1.3	2.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.8	-0.5	-1.6	-2.4	-1.0	-1.3	-1.3
Breast Cancer	0.5	1.2	3.8	0.2	-0.9	0.1	1.9	0.3	-1.7
Ovarian Cancer	0.7	1.0	2.2	-1.0	1.5	0.5	-0.9	0.5	1.2
Prostate Cancer	1.0	1.5	4.6	0.3	1.5	1.2	-0.1	0.6	2.1
Age at First Birth	0.1	0.2	1.0	0.4	-0.1	-0.1	-0.2	1.0	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.5	-1.5	-0.5	-1.6	-0.7	-0.1	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	3.6	1.9	-0.8	-0.7	0.0	0.0	0.0
Crohns Disease (2012)	0.6	1.0	3.2	0.7	-1.4	-1.8	0.3	-0.6	0.0
Mean Putamen Volume	0.6	0.7	1.5	0.8	0.0	0.8	-1.2	1.0	-0.6
Fasting Glucose	0.7	0.8	2.7	1.6	-0.5	-0.6	-1.0	-0.1	0.7
HbA1C	3.1	3.5	10.1	-1.0	1.1	0.4	-3.2	1.6	2.4
HDL Cholesterol	1.4	2.3	4.7	1.4	-2.2	-0.0	2.1	-1.0	-1.3
LDL Cholesterol	2.5	4.0	7.8	-2.8	1.6	-1.3	-2.4	2.2	1.3
Lupus	1.0	1.6	5.8	1.0	1.2	2.4	0.2	0.7	0.8
Neuroticism (2016)	0.9	1.2	3.5	1.1	-0.4	-0.6	0.7	-1.9	1.3
Primary Biliary Cirrhosis	1.0	1.5	4.1	1.1	-2.0	-1.3	0.6	-0.5	1.2
Rheumatoid Arthritis	1.6	2.3	4.1	1.8	0.3	2.0	1.9	-1.7	0.0
Schizophrenia (2014)	0.2	0.3	0.9	0.2	0.9	-0.5	-0.8	-0.5	0.0
Triglycerides	0.3	0.5	1.0	-0.4	1.0	-0.2	-0.9	0.9	0.1
Type 2 Diabetes (T2D) (2012)	1.2	1.3	6.4	0.9	-0.9	-2.5	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.4	0.3	-0.6	-0.2	0.0	0.0	0.0
Blood Eosinophil Count	0.3	2.6	6.6	-0.2	2.5	1.4	-0.8	2.6	-0.5
Blood Platelet Count	0.8	9.1	32.4	3.8	-2.2	1.6	5.7	-0.4	-0.2
Blood Red Count	0.3	2.5	9.1	1.1	1.7	1.3	-0.3	-0.1	3.0
Blood White Count	0.2	1.7	5.4	2.3	-0.2	1.3	1.0	1.0	1.0
Heel T-Score	0.5	3.9	11.7	-1.9	0.8	-1.1	-3.4	2.1	1.5
BMI	0.7	3.8	13.0	-0.8	-1.1	-3.6	-2.8	-0.3	-0.5
Height	0.1	1.2	2.7	0.4	-0.9	-1.6	-1.3	-1.2	-0.7
Waist Hip Ratio (WHR)	0.6	2.6	9.5	-1.4	0.3	-0.8	-3.1	1.3	1.3
Systolic Blood Pressure	1.1	5.6	9.7	-1.1	3.1	1.9	-2.3	2.0	3.1
Smoking Status	0.5	1.1	3.9	-0.8	1.1	0.8	-0.5	2.0	-0.2
Allergy or Eczema	1.1	2.9	8.7	-3.0	1.5	-0.6	-1.0	2.3	0.2
Cardiovascular Disease	1.6	5.3	12.2	-1.0	2.7	-0.7	-3.2	0.6	3.5
Hypothyroidism (self reported)	0.2	0.5	1.3	1.2	-0.2	-0.1	0.5	1.0	0.3
Respiratory disease	0.4	1.0	3.1	1.0	0.1	0.8	1.0	0.4	-1.8
Type 2 Diabetes (T2D) (2018)	3.1	5.8	12.7	-0.8	-0.2	-2.6	-3.6	3.3	2.0
Lung FEV1/FVC ratio	8.6	43.4	114.5	-4.2	7.7	0.2	-10.7	5.6	6.2
Lung FVC	1.0	5.1	14.6	2.7	0.2	1.7	3.8	-2.1	-1.0
Neuroticism	1.1	2.7	7.9	1.6	1.2	0.7	2.8	-0.5	1.9
Chronotype (morning person)	0.8	1.7	4.8	0.6	0.7	0.3	-2.2	1.9	-1.2
Hair Pigment	0.0	0.6	1.9	0.3	0.8	1.4	0.3	0.4	-0.8
Tanning	0.1	1.2	3.3	0.1	0.8	1.6	1.8	-0.7	-0.3
Hand grip strength (left)	1.3	3.5	11.9	0.1	-2.6	-0.7	1.5	-0.0	-3.4
Number of treatments/medications taken	0.6	1.0	4.1	0.5	0.9	-0.3	-0.8	0.2	2.0
Average weekly spirits intake	0.4	0.5	1.3	0.4	0.1	0.1	0.9	-1.0	1.1
Sensitivity / hurt feelings	0.4	0.6	2.1	1.2	0.3	0.3	0.3	-0.4	1.4
Frequency of depressed mood in last 2 weeks	1.1	1.6	8.5	0.0	0.0	0.6	2.9	0.5	-0.5
Hearing difficulty/problems: Yes	0.6	1.0	4.3	0.6	0.8	0.2	-0.5	-0.4	2.1
Relative age of first facial hair	0.5	1.1	3.4	-0.9	-1.9	-0.6	0.7	-1.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	0.1	0.9	1.0	0.0	-1.3	-0.7
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.7	1.6	-0.8	0.3	1.1	-1.6	-0.4
Ever had hysterectomy (womb removed)	1.5	1.7	4.3	-0.3	1.8	1.3	-0.9	2.1	-0.1
Systolic blood pressure, automated reading	1.1	3.2	6.3	-0.4	2.3	1.3	-1.5	1.8	2.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.0	1.0	-0.5	-0.8	-1.0	-1.0	1.0
Angina	0.9	1.2	3.3	-0.2	1.8	0.3	0.3	1.0	1.7
Medication for hormone replacement therapy	0.4	0.5	1.5	0.0	0.1	1.1	-0.2	-0.4	-1.2
Vitamin and mineral supplements	0.4	0.6	1.6	-1.0	1.3	0.4	0.0	0.2	-1.0
Supplements: Zinc	0.6	0.6	1.9	-0.2	-1.4	0.1	0.6	-0.5	-1.1
Medication: Co-codamol	1.0	1.1	3.4	-1.8	-0.3	-0.8	-0.1	1.3	-1.0
Medication: Metformin	1.5	2.1	5.7	0.4	-0.6	-2.4	-1.0	1.3	2.0
Diabetes (father)	2.0	2.4	10.0	-0.2	0.5	-1.0	-3.2	-0.1	1.8
Diabetes (mother)	2.2	2.9	9.3	-0.2	-0.0	-1.5	-3.0	2.1	1.1
Severe depression (siblings)	1.9	2.1	4.0	0.1	-1.9	-1.4	1.7	-2.0	-0.5
Pack years adult smoking proportion	0.3	0.5	1.1	0.4	0.5	0.9	-1.1	0.7	0.4
Impedance of leg (right)	1.1	5.6	11.6	-0.1	2.9	2.8	-1.2	2.0	3.4
Leg fat-free mass (left)	0.6	3.4	8.6	-0.4	-1.9	-2.9	-0.2	-1.7	-2.2
Trunk fat percentage	0.5	1.9	5.9	-0.2	1.0	-0.9	-1.9	-0.3	2.4
Hand grip strength (right)	2.2	5.9	22.4	-0.8	-2.8	-1.9	0.9	-0.7	-4.7
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.3	0.1	-0.1	0.3	0.3	-0.5
Current tobacco smoking	0.7	1.2	4.6	-0.8	0.8	0.7	-0.8	2.1	-0.0
Average weekly fortified wine intake	0.4	0.5	1.0	0.7	0.7	-0.2	-1.0	1.0	-0.2
Maternal smoking around birth	0.3	0.4	1.2	0.1	-0.6	-0.3	0.9	-0.1	1.1
Fed-up feelings	0.7	1.3	4.0	2.0	0.8	1.0	1.0	0.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	5.6	-0.1	-0.2	0.4	2.4	0.6	-0.0
Relative age voice broke	0.2	0.3	1.3	-1.1	-0.6	-0.0	-0.3	-0.3	0.5
Taking other prescription medications	0.5	0.8	1.4	1.1	0.3	0.8	1.2	-0.5	1.1
Age when periods started (menarche)	0.7	1.6	3.7	0.9	-1.3	-0.7	1.9	-1.4	-0.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	6.0	1.4	0.6	2.5	0.2	0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.1	-0.7	-0.2	-0.8	-0.5	0.9	1.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.4	-0.3	0.8	-0.7	-1.4	1.7	2.1
Qualifications: CSEs or equivalent	0.6	0.7	3.4	0.1	0.0	1.9	0.8	-0.2	-0.6
Serious illness, injury or assault to yourself	0.7	0.9	4.0	-0.1	-0.4	0.3	2.0	-0.1	-1.1
High blood pressure	1.7	4.6	16.1	-0.3	2.0	-0.4	-2.5	1.0	4.0
Hayfever, allergic rhinitis or eczema	1.3	2.8	10.6	-3.3	0.9	-1.2	-1.1	1.5	-0.5
Multivitamins +/- minerals	0.7	0.9	3.1	0.8	-1.0	-0.7	-0.6	-0.4	1.8
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.3	0.7	0.2	-0.1	-0.4	0.1
Supplements: Glucosamine	0.1	0.2	0.4	-0.2	0.3	0.2	0.7	-0.6	0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.9	1.0	-0.2	0.3	-0.1	0.7	-0.3
Medication: Atenolol	2.8	3.5	10.6	1.9	1.9	1.3	-0.7	1.2	3.2
Medication: Levothyroxine sodium	0.2	0.3	0.7	0.7	-0.3	-0.5	0.8	0.4	0.4
Sitting height	0.2	1.5	3.7	0.9	-1.9	-1.4	0.5	0.6	-1.2
Chronic bronchitis/emphysema (father)	1.6	1.9	3.6	-1.9	-1.5	-1.0	1.7	-1.2	-0.4
High blood pressure (mother)	0.0	0.1	0.1	-0.1	0.4	0.1	0.0	-0.4	-0.2
Body mass index (BMI)	0.4	1.8	7.1	-0.6	-1.1	-2.7	-1.3	-0.5	-0.1
Impedance of leg (left)	0.9	4.3	8.6	0.1	2.4	2.8	-0.8	1.6	2.9
Leg predicted mass (left)	0.6	3.4	8.8	-0.4	-1.9	-3.0	-0.2	-1.6	-2.2
Trunk fat mass	0.3	1.4	3.2	-0.4	0.4	-1.6	-1.8	-0.5	1.4
Waist circumference	0.4	1.5	4.3	-0.6	-0.6	-2.1	-1.9	-0.4	0.4
Number of incorrect matches in round	0.6	1.0	2.5	1.6	-0.3	0.0	0.4	1.0	1.5
Past tobacco smoking	0.4	0.7	1.9	-0.5	-0.7	0.0	-0.9	0.8	-1.4
Alcohol usually taken with meals	0.3	0.6	2.7	0.1	-0.2	0.4	-0.0	-0.7	-1.6
Nervous feelings	1.4	2.6	4.7	0.9	1.7	2.1	2.2	0.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	6.4	0.8	1.1	2.3	2.5	0.5	0.9
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.7	0.4	0.4	0.5	0.7	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	2.4	0.7	-1.4	-0.2	1.6	-0.0	-0.4
Had menopause	0.8	1.0	2.1	1.2	1.4	1.4	0.2	-0.6	0.3
Had other major operations	0.9	1.1	2.7	-1.2	1.6	0.9	-0.9	0.5	0.5
Forced vital capacity (FVC)	0.4	1.6	6.1	0.7	-0.6	-0.1	1.0	-1.4	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	4.1	-0.5	-0.3	-0.8	-0.7	0.8	2.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	2.7	0.1	1.6	1.2	-0.3	0.1	1.6
Qualifications: None of the above	0.9	2.0	2.9	1.5	1.7	1.6	1.3	1.6	0.2
Financial difficulties in last 2 years	0.7	0.9	3.0	-0.9	0.6	0.5	1.7	-0.6	0.7
Mouth/teeth dental problems	0.5	0.8	1.7	-0.5	0.5	1.2	-1.2	1.3	-0.2
Heart attack	0.4	0.6	1.1	-0.6	0.9	0.5	-0.7	0.4	1.1
Allergy	1.0	2.2	6.6	2.6	-1.1	0.3	0.7	-2.1	0.7
Pain all over the body in last month	0.3	0.3	0.9	0.9	-0.2	0.3	0.8	-0.2	-0.6
Diabetes (self-reported)	2.1	3.3	8.6	-0.0	-0.9	-2.9	-2.2	1.9	1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.7	0.4	-0.9	-1.3	0.0	0.9	0.0
Medication: Ramipril	2.4	3.1	6.3	-1.3	2.0	0.7	-2.4	0.1	2.5
Medication: Simvastatin	1.1	1.6	4.0	0.1	-0.3	-1.5	-1.7	-0.8	2.0
Fluid intelligence score	0.9	1.9	3.6	-1.3	-1.3	-1.9	-1.7	-0.5	-1.2
Illnesses of siblings	1.5	2.0	7.5	-2.7	1.0	0.4	-1.4	1.3	-0.2
Neuroticism score	0.8	1.7	6.1	1.2	0.5	0.7	2.5	-0.9	1.0
Weight	0.5	2.4	8.1	-0.5	-1.3	-2.9	-1.6	-1.0	-0.8
Impedance of arm (right)	0.6	2.8	6.7	0.5	1.7	2.6	0.8	-0.5	2.4
Arm fat percentage (right)	0.2	0.9	2.5	-0.5	0.3	-1.1	-1.0	-0.6	1.6
Trunk fat-free mass	0.8	4.8	11.6	-0.4	-2.4	-3.4	-0.8	-1.2	-3.1
Hip circumference	0.2	0.7	1.8	-0.4	-0.1	-1.4	-1.3	0.4	-0.6
Time employed in main current job	0.5	0.5	2.2	0.5	0.7	1.5	0.5	0.2	0.1
Alcohol intake versus 10 years previously	1.2	1.8	6.9	-0.4	0.7	-0.5	-1.6	2.6	1.0
Father’s age at death	1.0	1.3	2.7	1.4	-0.6	1.6	1.3	-0.8	-0.8
Worrier / anxious feelings	0.1	0.2	0.5	0.2	0.7	0.2	0.5	-0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.2	2.1	-0.8	1.1	2.3	-1.0	-0.9
Falls in the last year	2.9	4.0	9.0	0.9	-3.0	-1.9	1.4	-2.0	-2.1
Hair/balding pattern: Pattern 3	0.6	1.0	5.2	-0.1	-0.2	0.7	2.3	-0.3	0.1
Number of live births	3.7	5.3	10.4	0.3	3.2	1.4	-2.1	2.7	2.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.4	-0.6	1.0	-0.5	-1.5	-0.3	-1.6
Pulse rate	1.0	1.7	3.5	-0.7	1.6	0.6	-1.8	1.9	0.6
Happiness	1.2	1.5	3.2	1.7	1.1	1.1	-0.5	-0.6	1.8
Noisy workplace	1.1	1.4	2.7	-1.0	1.6	-0.0	-1.4	1.6	0.0
Qualifications: A levels/AS levels or equivalent	1.1	2.5	6.8	0.3	-1.9	-2.6	-0.6	-2.0	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.5	-0.1	-1.1	-1.3	0.5	-1.6	-0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	6.7	1.6	0.1	0.6	2.6	-1.0	0.8
Asthma	0.9	1.8	7.1	0.3	0.6	0.9	0.4	1.4	-2.7
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.0	1.0	-1.2	0.3	2.2	-1.0	-2.2
Medication: Cholesterol lowering	0.9	1.4	5.2	-0.6	0.8	-1.0	-1.0	0.0	2.3
Depression (self-reported)	1.2	1.4	3.8	-1.7	-0.3	-0.9	1.9	-0.8	-0.4
Medication: Lansoprazole	0.8	1.0	1.9	1.4	0.3	1.4	1.1	0.8	-0.0
Prospective memory result	0.8	1.0	2.9	1.7	-0.1	0.3	0.8	0.8	1.3
Lung cancer (father)	0.3	0.4	1.8	-1.4	-0.1	-0.5	-0.4	-0.4	0.0
Illnesses of mother	0.4	0.5	1.3	-0.4	0.4	1.0	-0.3	1.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.8	-0.2	1.3	-0.4	-1.7	0.3	-1.4
Pulse wave Arterial Stiffness index	1.2	1.3	3.2	-1.3	0.7	-0.4	-1.8	1.6	0.3
Impedance of arm (left)	0.6	2.7	6.8	0.6	1.6	2.1	1.4	-0.4	2.6
Arm fat mass (right)	0.3	1.3	4.5	-0.7	-0.4	-2.1	-1.3	-0.8	0.6
Trunk predicted mass	0.8	4.8	11.6	-0.4	-2.4	-3.4	-0.8	-1.2	-3.1
Standing height	0.1	0.8	2.3	0.2	-0.6	-0.8	-0.7	-1.1	-1.5
Length of working week for main job	1.1	1.2	6.3	0.6	0.3	0.3	2.5	0.3	-0.6
Exposure to tobacco smoke at home	2.7	3.0	6.5	0.1	1.9	1.5	-1.9	2.5	1.5
Breastfed as a baby	0.3	0.4	0.9	1.0	0.5	0.9	-0.3	-0.2	-0.3
Tense / ‘highly strung’	1.7	2.8	6.2	0.7	2.4	2.5	1.8	-0.1	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.4	0.9	0.1	0.4	1.6	-0.6	-0.3
Hair/balding pattern: Pattern 4	0.9	2.1	6.5	2.5	0.6	0.4	-1.6	-0.7	1.6
Birth weight of first child	0.3	0.5	1.7	-0.5	0.2	-0.6	-1.3	-0.4	-0.5
Peak expiratory flow (PEF)	0.7	1.5	3.1	-1.4	1.3	-0.6	-1.8	0.9	-1.1
Pulse wave reflection index	0.9	1.1	2.0	-1.1	1.1	0.8	-1.3	1.4	0.0
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.1	-1.8	1.8	0.3	-0.4	0.7	1.0
Loud music exposure frequency	1.8	2.0	8.3	0.2	-0.6	-1.6	0.6	-2.9	-0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.5	0.6	-1.4	-1.8	0.2	-1.9	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.9	0.1	1.2	0.2	-1.1	-0.5	1.4
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.3	0.2	0.4	-0.4	-0.9	-0.0
Medication: Paracetamol	2.5	4.1	10.2	2.0	-2.6	0.1	3.2	-1.1	-1.6
Headache pain in last month	0.8	1.3	3.4	1.8	-1.6	0.3	-0.2	-1.1	-0.9
Medication for cholesterol, blood pressure or diabetes	3.0	4.9	16.4	-0.1	-2.7	-0.4	2.3	-0.8	-4.1
Glaucoma (self-reported)	0.3	0.3	0.9	0.4	0.0	0.0	1.0	-0.9	0.1
Gout (self-reported)	1.3	1.8	5.0	2.2	-1.9	-0.5	0.3	-1.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.4	1.3	-0.1	0.4	1.5	0.6	0.9
Medication: Amlodipine	1.9	2.7	6.4	-1.2	1.3	-1.4	-1.7	1.2	2.5
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.5	0.1	1.7	2.1	-0.0	0.1	-0.9
Birth weight	1.6	3.5	7.2	-1.6	-1.5	-2.4	-2.7	-0.8	-1.7
Chronic bronchitis/emphysema (mother)	2.3	2.6	5.6	2.4	-1.9	0.4	1.9	-1.7	-0.2
High blood pressure (siblings)	0.3	0.5	0.8	0.8	-0.3	-0.9	0.6	-0.8	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.5	4.4	1.4	-0.3	0.1	1.1	-1.1	-2.1
Body fat percentage	0.4	1.7	4.4	-0.6	0.9	-1.0	-2.0	-0.0	2.1
Leg fat percentage (right)	0.6	2.3	6.6	-1.1	1.2	-1.0	-2.6	0.5	1.8
Arm fat-free mass (right)	0.7	3.4	10.0	-0.6	-1.7	-3.2	-1.3	-0.6	-2.3
Exposure to tobacco smoke outside home	1.4	1.8	4.7	0.2	2.2	2.2	0.0	0.9	0.8
Comparative body size at age 10	0.3	0.8	2.9	-0.9	0.4	-1.0	-1.7	-0.2	0.4
Number of full brothers	0.8	1.0	2.0	1.3	-1.3	-0.8	0.2	-1.4	-0.5
Worry too long after embarrassment	0.7	1.1	2.0	0.9	-1.1	-0.7	1.2	-1.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	1.1	0.0	0.2	0.8	-0.7	0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	1.1	0.8	1.1	-0.7	0.3	-0.7
Number of children fathered	0.6	0.7	1.1	-1.1	-0.2	-0.1	-0.8	1.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.5	-1.6	-0.0	-0.8	-0.6	-0.7	0.5
Age at first live birth	1.8	3.2	11.1	-3.3	-0.9	-1.4	-0.5	0.6	-2.2
Pulse wave peak to peak time	1.5	1.7	4.1	1.5	-0.7	0.5	2.0	-1.7	-0.3
Health satisfaction	0.4	0.6	1.5	-0.2	1.0	1.2	-0.0	0.5	-0.7
Shortness of breath walking on level ground	1.1	1.4	6.1	0.7	1.1	0.3	0.5	0.1	2.5
Qualifications: College or University degree	0.5	1.7	2.7	-0.9	-0.7	-1.2	-1.5	-1.6	-1.7
Eye problems/disorders: None of the above	0.4	0.4	1.3	-0.4	0.9	1.2	-0.5	0.1	-0.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.9	-0.8	-0.2	-0.7	-0.1	-0.9	-2.0
Emphysema/chronic bronchitis	2.2	2.4	7.0	0.8	-0.2	1.0	2.2	-2.6	1.0
Medication for pain relief, constipation, heartburn	1.5	2.5	5.2	-2.3	1.9	0.1	-2.0	1.3	0.3
Neck or shoulder pain in last month	0.5	0.7	2.1	0.7	-0.3	0.4	1.4	0.9	-0.7
Medication: Blood pressure	2.5	4.4	13.2	0.4	2.5	0.7	-2.5	0.2	3.6
Angina (self-reported)	0.9	1.2	3.2	-0.2	1.7	0.3	0.7	0.6	1.8
Migraine (self-reported)	2.2	2.7	7.0	1.0	-2.6	-2.4	-0.5	-1.0	-1.3
Medication: Ibuprofen	1.0	1.2	3.2	0.0	-0.9	-0.3	1.8	-1.0	-1.5
Medication: Allopurinol	1.7	2.2	7.2	2.7	-1.8	-1.4	0.4	-0.9	0.0
Medication: Omeprazole	0.8	1.0	2.6	0.2	1.5	0.7	0.0	0.7	1.6
Medication: Seretide 50 evohaler	1.1	1.3	5.4	0.0	-0.3	0.7	2.3	-1.3	-0.3
Mean time to correctly identify matches	0.7	1.3	6.0	-0.5	1.0	-0.1	-0.9	0.2	2.4
Heart disease (mother)	0.4	0.5	1.0	-0.6	0.7	0.2	0.1	-1.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	-0.6	-0.9	-0.7	1.3	1.0	-1.2
Whole body fat mass	0.3	1.4	3.3	-0.8	0.3	-1.6	-1.8	-0.3	1.2
Leg fat mass (right)	0.4	1.5	4.7	-1.1	0.5	-1.5	-2.2	0.0	0.8
Arm predicted mass (right)	0.7	3.6	10.7	-0.6	-1.8	-3.3	-1.2	-0.7	-2.4
Pulse rate, automated reading	1.1	3.5	11.5	0.6	1.0	0.5	-3.4	2.6	1.1
Alcohol intake frequency.	0.7	1.6	4.6	-0.7	1.0	-0.5	-2.1	1.7	0.1
Comparative height size at age 10	0.1	0.8	2.9	0.2	-0.5	-1.7	-0.3	-0.8	-0.9
Number of full sisters	0.8	1.0	2.2	1.5	-0.8	1.1	1.0	-1.0	-0.5
Suffer from ‘nerves’	0.7	1.1	3.7	-0.3	1.9	1.2	0.3	1.1	0.4
Overall health rating	0.9	1.9	6.7	2.6	-0.2	1.0	1.8	-0.7	0.3
Chest pain or discomfort	0.6	0.8	3.4	0.7	-0.2	-0.0	0.9	-1.8	0.4
Had major operations	0.6	0.7	1.9	0.2	-0.6	-0.6	1.4	-1.0	0.9
Age at last live birth	1.6	2.3	10.8	-3.3	0.4	-0.9	-0.9	0.7	-0.9
Family relationship satisfaction	1.1	1.4	3.8	0.4	1.1	0.1	-1.0	-1.4	2.0
Leg pain on walking	1.9	2.4	4.8	-1.8	2.1	1.2	-0.6	2.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.1	-1.4	0.6	-0.6	-1.0	0.7	1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	-0.6	0.7	1.2	1.1	0.7	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.2	0.4	-0.0	-0.1	-1.1	0.6	-0.5
Medication: Aspirin	0.6	0.7	2.9	-0.2	-0.5	-1.1	-0.3	0.2	1.7
Supplements: Vitamin C	0.7	0.9	2.6	0.3	-1.6	-0.7	-0.4	-1.2	-0.7
Knee pain experienced in last month	1.1	1.8	4.2	-0.3	0.0	-2.0	-1.5	1.4	1.5
Hypertension (Self-reported)	1.5	4.3	15.3	-0.5	1.8	-0.9	-2.4	0.4	3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.6	-0.1	0.8	1.0	1.3	-0.4	1.1
Illnesses of father: Heart disease	2.3	3.2	7.2	2.7	-1.3	0.4	2.2	-2.3	-0.2
Illnesses of siblings: Diabetes	0.6	0.8	3.0	0.6	0.0	-0.6	-0.9	0.1	1.7
Smoking status: Previous	0.8	1.2	2.2	0.8	0.5	-0.0	1.4	-1.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.1	0.4	-1.2	-0.6	-0.6	0.3	-1.8
Whole body fat-free mass	0.8	4.3	10.6	-0.5	-2.2	-3.2	-0.7	-1.3	-2.9
Leg fat-free mass (right)	0.7	3.8	7.7	-0.2	-2.1	-2.8	0.1	-1.9	-2.6
Arm fat percentage (left)	0.2	1.0	2.6	-0.5	0.3	-1.4	-0.9	-0.5	1.6
Average weekly red wine intake	1.1	1.7	3.9	-1.1	0.4	-0.5	-1.7	1.3	-2.0
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.0	-0.8	-1.7	-0.3	0.9	-1.0	-0.9
Mood swings	0.5	0.8	2.6	-0.2	0.8	0.7	1.0	-0.4	1.6
Loneliness, isolation	0.2	0.3	1.1	0.3	0.4	-0.1	1.1	-0.7	0.1
Long-standing illness, disability or infirmity	0.5	0.7	1.4	-1.1	1.0	0.3	-1.2	0.5	-0.2
Ever had bowel cancer screening	3.7	4.4	8.3	2.6	-2.2	-1.4	2.0	-2.9	0.8
Diabetes diagnosed by doctor	3.1	5.1	8.8	0.1	-0.4	-3.0	-3.0	2.4	2.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.2	-1.8	1.2	0.7	1.1	0.6	0.3
Friendships satisfaction	0.4	0.5	1.9	-0.1	-0.4	-0.6	-0.5	-1.4	0.4
Qualifications: nursing, teaching	0.7	1.1	3.8	-0.1	-0.8	-1.0	0.0	-2.0	1.0
Commuting to job workplace: Walk	2.4	2.6	5.4	2.3	-2.3	-0.9	0.8	-1.8	0.2
Eye problems/disorders: Cataract	0.6	0.7	2.7	0.1	-0.3	-0.3	1.0	1.6	0.3
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.8	-0.4	-2.0	-2.4	0.7	-1.6	0.2
Medication for cholesterol	1.4	2.2	5.7	0.2	-0.2	1.4	2.4	-0.7	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	1.0	-0.2	0.4	0.4	0.7	1.1
Back pain experienced in last month	1.4	2.1	5.8	0.4	-1.8	-2.4	1.4	-0.9	-0.6
Mineral and other dietary supplements	0.2	0.3	1.0	-0.1	0.0	0.1	1.0	0.8	-0.4
Breast cancer (self-reported)	2.2	2.7	8.0	-1.3	2.8	1.3	-0.6	1.4	1.4
Asthma (self-reported)	0.9	1.8	7.7	0.0	0.3	0.5	0.7	1.4	-2.8
Osteoporosis (self-reported)	1.0	1.3	2.9	1.7	-1.2	0.4	0.8	-1.6	-0.4
Osteoarthritis (self-reported)	1.9	2.4	5.6	0.6	2.4	1.4	1.0	1.0	2.2
Medication: Aspirin	0.6	0.8	3.2	-0.2	-0.5	-1.1	-0.6	0.1	1.8
Medication: Gliclazide	1.8	2.0	4.8	1.8	-1.6	-2.2	-0.6	0.0	1.2
Illnesses of father: None of the above (group 1)	0.7	0.8	2.2	0.6	0.9	0.7	-0.7	1.5	0.7
Smoking status: Current	0.9	1.4	5.6	-0.8	0.8	0.4	-1.2	2.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	12.4	-2.0	2.8	-0.7	-3.5	2.4	-0.9
Whole body water mass	0.7	4.1	10.0	-0.4	-2.1	-3.2	-0.6	-1.4	-2.8
Leg predicted mass (right)	0.7	3.8	7.2	-0.2	-2.1	-2.7	0.2	-1.9	-2.7
Arm fat mass (left)	0.3	1.3	4.5	-0.8	-0.3	-2.1	-1.4	-0.5	0.7
Number of self-reported non-cancer illnesses	0.8	1.4	4.7	1.0	1.1	0.3	1.0	-0.6	2.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.3	-0.3	-0.6	-0.1	-0.6	-0.5
Miserableness	0.4	0.7	3.2	0.6	-0.1	0.1	1.8	-0.2	0.6
Guilty feelings	0.4	0.6	2.4	-0.6	-0.3	0.2	0.8	-0.5	-1.5
Wears glasses or contact lenses	1.1	1.3	2.5	1.6	-0.9	-0.2	1.2	-1.3	1.2
Ever taken oral contraceptive pill	0.9	1.0	3.5	0.3	-1.3	-0.1	-0.0	-1.9	-0.5
Hearing aid user	1.7	1.9	5.9	0.8	-2.0	-2.4	0.9	-0.6	-0.1
Mother’s age at death	0.6	0.7	2.0	-0.0	-0.7	-1.0	1.4	-0.2	-0.8
Financial situation satisfaction	0.8	1.0	3.1	0.9	0.2	1.0	0.6	-1.8	0.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.3	0.8	-1.7	-0.9	0.5	0.1	-1.8
Commuting to job workplace: Public transport	2.9	3.4	7.7	0.7	-2.0	-1.2	0.7	-2.5	-2.8
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	0.1	0.1	-0.3	1.2	-1.5	-0.3
Medication: Blood pressure	1.5	2.9	12.1	0.4	0.1	-1.5	-1.7	0.2	3.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	-0.4	-0.3	-0.2	0.6	-0.1	-1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	1.4	-0.0	0.8	-0.7	-0.1	0.8
High cholesterol (Self-reported)	0.9	1.7	7.3	-0.5	0.8	-0.6	-1.2	0.4	2.7
Medication: Bendroflumethiazide	1.4	2.2	4.3	0.1	1.7	1.0	-2.1	1.2	1.8
Medication: Paracetamol	1.8	2.8	6.5	1.6	-2.3	-0.3	2.6	-0.6	-1.4
Medication: Lisinopril	1.7	2.2	6.7	0.0	0.7	-0.3	-2.1	1.3	2.6
Medication: Atorvastatin	3.4	4.2	16.6	-0.2	-0.1	-2.2	-0.9	1.7	4.1
Illnesses of father: High blood pressure	0.6	0.8	3.0	-0.4	-0.1	-0.3	0.9	-0.7	-1.7
Alcohol drinker status: Never	0.4	0.4	1.3	-0.3	-0.6	-0.5	0.7	-1.2	0.4
Ever smoked	0.3	0.6	1.8	0.1	0.9	0.7	0.5	-0.6	1.3
Basal metabolic rate	0.7	3.7	9.8	-0.5	-2.0	-3.1	-0.8	-1.3	-2.4
Leg fat percentage (left)	0.4	1.5	4.5	-0.9	0.8	-1.0	-2.1	0.2	1.4
Arm fat-free mass (left)	0.6	3.0	8.0	-0.3	-1.7	-2.8	-1.2	-0.6	-2.3
Number of operations (self-reported)	0.9	1.3	3.2	0.6	0.4	1.0	1.8	-0.9	1.4
Average weekly beer plus cider intake	0.4	0.5	1.1	-0.2	-1.1	-0.9	0.5	-0.3	-0.9
Irritability	1.6	2.8	14.4	0.7	-0.2	1.0	3.8	-0.8	-0.1
Risk taking	1.7	2.5	8.0	-2.5	0.7	-0.6	-2.8	0.5	-0.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	5.1	-0.1	0.8	0.7	-1.1	0.5	2.3
Fractured/broken bones in last 5 years	0.2	0.3	0.9	-0.5	-0.5	-0.9	0.4	-0.4	-0.4
Age started oral contraceptive pill	2.5	3.1	8.9	3.0	-2.3	-0.6	1.2	-1.6	-0.2
Diastolic blood pressure, automated reading	4.4	13.5	26.3	-2.7	4.9	1.1	-5.1	3.1	3.6
Ever depressed for a whole week	2.7	3.3	11.6	-0.1	2.1	1.2	-1.5	0.6	3.4
Unable to work because of sickness or disability	2.5	3.2	6.2	-0.2	-2.1	-2.0	2.1	-0.3	-2.5
Commuting to job workplace: Cycle	1.9	2.3	8.4	-0.8	-1.6	-1.3	0.2	-0.8	-2.9
Myopia	0.6	0.8	2.8	-0.8	0.1	0.1	-1.7	-0.2	-1.2
Vascular/heart problems diagnosed by doctor	1.7	4.5	15.4	0.1	-2.4	0.1	2.3	-1.0	-3.9
Cholesterol lowering medication	1.8	2.7	8.8	-0.1	0.1	-1.3	-2.2	0.9	3.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.9	1.0	0.8	-0.1	0.0	0.7
Pain experienced in last month	0.4	0.7	1.5	-0.6	1.0	1.2	-1.0	0.4	-0.0
Supplements: Calcium	1.7	1.9	4.3	0.6	-2.1	-0.7	1.6	-1.3	-1.5
Basal cell carcinoma (self-reported)	1.2	1.5	3.3	-1.1	1.1	-0.4	-1.8	1.4	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-0.5	1.0	0.7	-0.6	0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.4	0.0	-0.0	0.2	0.0	-1.2	-0.2
Heart disease (siblings)	1.3	1.6	5.2	2.3	-0.8	-0.3	1.5	-0.5	1.0
Alcohol drinker status: Previous	0.5	0.6	1.5	0.9	0.5	0.4	-1.2	0.2	-1.0
Pack years of smoking	0.7	1.0	1.7	0.6	1.0	1.3	-1.2	0.9	0.7
Impedance of whole body	0.8	4.3	10.1	0.1	2.5	2.9	-0.0	1.0	3.2
Leg fat mass (left)	0.3	1.2	3.5	-0.8	0.2	-1.6	-1.9	-0.2	0.7
Arm predicted mass (left)	0.6	3.1	7.9	-0.4	-1.6	-2.8	-1.5	-0.6	-2.3