Hub : Genes

ANKFY1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.2650 0.0850 2.6e-03 -0.009 NA 0.004 NA -0.005 9.5e-01 NA 2.3e-01 NA 5.3e-01
2 GTEx Artery Tibial 0.0694 0.0368 6.6e-03 -0.003 NA 0.003 NA -0.002 7.2e-01 NA 1.6e-01 NA 5.0e-01
3 GTEx Cells Transformed fibroblasts 0.0970 0.0380 2.1e-04 0.028 NA 0.020 NA 0.016 3.4e-03 NA 1.1e-02 NA 2.0e-02
4 ROSMAP Brain Pre-frontal Cortex 0.0489 0.0212 2.4e-03 0.026 0.015 0.020 0.016 0.018 2.6e-04 4.3e-03 1.2e-03 3.2e-03 1.8e-03
5 YFS Blood 0.0571 0.0141 1.8e-12 0.044 0.045 0.041 0.048 0.042 3.6e-14 1.2e-14 2.5e-13 2.5e-15 1.3e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.1 1.7 3.4 -1.1 0.5 -1.5 1.2 1.9
Bipolar Disorder or Schizophrenia 1.0 2.3 5.5 -0.3 0.9 -1.6 1.6 2.3
Depressed Affect (Nagel 2018) 0.6 1.3 2.6 1.0 -0.9 1.5 -1.6 -0.3
Depression (Nagel 2018) 3.3 5.0 10.7 -1.4 -2.1 3.3 -2.8 -0.3
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.5 -0.1 2.1 -1.9 1.9 -0.6
Neuroticism (Nagel 2018) 0.9 2.2 5.9 -0.1 -1.3 2.4 -1.6 -0.6
Schizophrenia (2018) 0.5 1.0 2.4 0.6 0.6 -0.9 1.2 1.6
Schizophrenia vs Biploar Disorder 0.3 0.4 1.0 -0.5 0.1 0.6 -0.3 -1.0
Worry (Nagel 2018) 0.5 1.0 2.6 -0.6 -1.2 1.6 0.0 -0.8
Alzheimer’s Disease (in mother) 0.6 0.7 2.4 0.1 -0.2 0.4 -0.8 1.6
Alzheimer’s Disease (in father) 1.8 2.0 3.0 1.7 0.2 -1.7 1.5 1.3
Alzheimer’s Disease (including proxy) 0.6 0.8 2.5 0.8 -0.9 0.1 -0.4 1.6
Crohns Disease (2017) 1.8 4.0 11.2 3.3 1.2 -0.9 2.2 -1.4
Irritable Bowel Disease (IBD) 0.9 2.1 6.5 2.5 0.8 1.1 -0.4 -1.5
Ulcerative Colitis (UC) 1.3 2.4 4.8 1.0 0.8 2.1 -2.2 -1.2
Major Depression (MDD) 0.2 0.3 0.8 0.3 -0.3 0.9 -0.4 -0.4
Reaction Time 1.5 2.8 5.8 2.0 1.1 -2.4 1.6 0.7
Verbal and Numeric Reasoning (VNR) 2.0 4.7 9.5 0.2 3.1 -2.2 2.6 -1.5
Breast Cancer 0.7 1.8 5.8 -0.8 -1.1 1.1 0.4 -2.4
Ovarian Cancer 1.4 1.8 4.5 -0.4 -0.6 -2.1 2.0 0.2
Prostate Cancer 1.1 1.5 2.9 -1.7 -1.6 0.8 -1.2 0.5
Age at First Birth 0.5 0.7 1.7 -1.1 -1.3 0.5 -0.5 0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 0.6 0.4 -0.4 -0.1 0.6
Coronary Artery Disease (CAD) 0.5 0.5 2.7 0.0 0.0 0.0 0.0 -1.6
Crohns Disease (2012) 0.8 1.3 3.2 1.8 0.9 -0.4 1.5 -0.5
Mean Putamen Volume 1.0 1.1 3.1 1.8 1.1 -0.9 0.8 -0.2
Fasting Glucose 0.3 0.3 0.9 0.2 -0.4 -0.9 0.5 -0.5
HbA1C 3.1 3.5 6.6 1.8 1.5 -2.6 1.1 2.0
HDL Cholesterol 1.1 1.8 4.8 -0.4 -1.4 2.2 -1.2 -0.7
LDL Cholesterol 2.4 3.8 6.6 2.2 0.8 -2.6 2.5 0.9
Lupus 2.0 3.0 8.4 1.1 -0.8 1.6 -2.9 1.4
Neuroticism (2016) 0.8 1.1 3.7 1.9 1.3 -0.1 0.3 0.2
Primary Biliary Cirrhosis 0.3 0.5 1.3 0.7 1.2 0.4 0.5 -0.5
Rheumatoid Arthritis 3.4 4.6 11.3 -1.0 -1.2 3.1 -3.4 0.2
Schizophrenia (2014) 0.6 1.3 3.0 -0.1 0.9 -1.0 1.2 1.7
Triglycerides 0.0 0.1 0.3 0.3 -0.2 0.0 0.1 -0.5
Type 2 Diabetes (T2D) (2012) 3.6 4.1 8.6 1.5 1.9 -2.1 2.9 -1.3
Ulcerative Colitis 1.6 2.3 6.0 -0.6 -0.7 2.5 -2.0 -0.9
Blood Eosinophil Count 0.4 2.8 8.8 -3.0 -1.7 -0.6 1.3 0.5
Blood Platelet Count 2.0 23.5 47.6 -2.3 -5.7 6.9 -5.5 -1.1
Blood Red Count 0.4 3.7 10.4 1.3 -1.2 -0.8 2.1 -3.2
Blood White Count 0.3 2.5 4.2 1.6 -1.1 1.8 -1.0 -2.0
Heel T-Score 1.5 12.0 19.4 3.0 4.0 -4.4 3.9 0.9
BMI 2.1 12.1 19.7 3.5 3.1 -4.4 4.2 -1.1
Height 0.6 11.8 19.3 3.9 1.9 -3.4 3.1 -4.4
Waist Hip Ratio (WHR) 2.7 12.1 21.3 2.6 3.8 -4.6 3.9 1.5
Systolic Blood Pressure 0.4 2.2 4.0 1.8 -0.0 -2.0 1.1 1.7
Smoking Status 0.2 0.6 2.2 -0.6 -0.1 0.4 -0.5 1.5
Allergy or Eczema 0.4 1.0 2.5 0.1 0.3 -1.4 0.8 1.6
Cardiovascular Disease 3.1 10.3 20.2 3.3 2.8 -4.5 3.4 -0.8
Hypothyroidism (self reported) 0.7 1.7 6.4 0.9 0.1 1.0 -0.5 -2.5
Respiratory disease 0.6 1.3 3.0 -0.1 -1.7 1.2 -1.0 -1.0
Type 2 Diabetes (T2D) (2018) 6.7 12.5 27.6 0.9 3.1 -4.9 5.3 -0.5
Lung FEV1/FVC ratio 9.0 45.7 97.4 2.8 6.5 -9.9 8.0 4.2
Lung FVC 2.3 12.0 26.0 -2.9 -3.7 5.1 -2.9 -1.8
Neuroticism 0.6 1.5 4.5 0.0 -0.7 2.1 -0.8 -1.3
Chronotype (morning person) 4.7 11.0 15.5 3.1 3.9 -3.0 3.6 -2.8
Hair Pigment 0.0 0.3 0.7 0.3 0.3 0.7 0.9 -0.5
Tanning 0.1 1.7 3.5 -1.9 -0.5 1.6 -1.5 -0.4
Hand grip strength (left) 1.5 4.0 9.0 -0.8 -2.5 2.1 -0.1 -3.0
Number of treatments/medications taken 1.4 2.5 8.6 2.9 0.8 -1.5 0.8 -0.5
Average weekly spirits intake 0.9 1.2 3.2 -0.5 -1.8 1.1 -0.8 -0.8
Sensitivity / hurt feelings 0.1 0.2 0.5 0.5 0.7 0.3 -0.1 0.2
Frequency of depressed mood in last 2 weeks 2.2 3.1 7.5 -1.3 -1.6 2.7 -1.9 -0.6
Hearing difficulty/problems: Yes 0.0 0.1 0.2 0.1 0.4 -0.3 -0.0 -0.1
Relative age of first facial hair 0.6 1.3 4.0 -0.1 0.1 1.0 -1.1 2.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.9 1.4 0.9 -0.4 -0.1 -0.6
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.2 1.5 0.8 0.5 -0.6 -1.0
Ever had hysterectomy (womb removed) 1.4 1.5 3.4 1.1 -0.0 -0.8 1.8 -1.6
Systolic blood pressure, automated reading 0.3 1.0 1.7 1.3 -0.7 -1.2 0.9 0.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.7 -0.2 1.4 -1.6 0.5 1.1
Angina 0.5 0.7 2.7 0.6 -0.3 -0.4 1.6 -0.1
Medication for hormone replacement therapy 0.4 0.4 1.0 -0.6 -1.0 0.4 -0.5 0.6
Vitamin and mineral supplements 0.6 0.8 2.8 -0.4 0.2 0.1 -1.0 1.7
Supplements: Zinc 0.4 0.4 0.9 -0.4 -0.8 0.9 -0.7 0.2
Medication: Co-codamol 0.2 0.2 0.6 -0.8 0.2 -0.5 0.1 -0.4
Medication: Metformin 2.9 4.0 10.4 1.0 1.5 -2.3 3.2 -1.1
Diabetes (father) 2.4 3.0 8.1 0.3 0.9 -2.9 2.2 1.0
Diabetes (mother) 2.0 2.6 7.6 1.6 1.1 -2.8 1.4 -0.1
Severe depression (siblings) 2.3 2.6 7.7 -0.3 -2.8 1.6 -1.6 -0.3
Pack years adult smoking proportion 0.5 0.8 2.2 1.5 0.1 -0.9 0.9 -0.0
Impedance of leg (right) 0.1 0.6 0.8 -0.1 0.9 -0.9 0.9 0.6
Leg fat-free mass (left) 1.0 5.1 8.6 2.1 0.9 -2.3 2.9 -2.6
Trunk fat percentage 2.8 11.2 17.9 4.2 2.0 -4.1 3.8 -1.7
Hand grip strength (right) 0.8 2.3 5.4 0.1 -2.0 1.3 0.5 -2.3
Townsend deprivation index at recruitment 1.3 1.9 3.6 -0.9 -1.9 1.5 -1.7 0.0
Current tobacco smoking 0.3 0.6 1.4 -0.3 -0.8 0.4 -0.7 1.2
Average weekly fortified wine intake 4.7 5.6 13.0 3.6 1.6 -2.2 2.3 -1.5
Maternal smoking around birth 0.1 0.2 0.3 0.5 -0.4 0.5 -0.1 -0.3
Fed-up feelings 0.8 1.4 4.0 -0.5 -0.7 1.6 -2.0 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 7.4 -1.2 -1.0 2.7 -2.0 -0.3
Relative age voice broke 0.6 1.0 4.4 -0.3 -0.3 -0.1 -0.5 2.1
Taking other prescription medications 0.4 0.7 1.2 0.6 -0.6 0.7 -1.0 -1.1
Age when periods started (menarche) 0.4 1.0 2.0 -1.0 -0.8 1.4 -0.4 -1.0
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 1.7 -0.8 -1.3 1.2 -1.3 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 2.8 1.1 1.0 -0.8 1.5 -1.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 0.7 -0.2 -0.4 -0.7 0.9
Qualifications: CSEs or equivalent 0.2 0.3 0.7 -0.1 -0.7 0.9 -0.4 0.4
Serious illness, injury or assault to yourself 1.8 2.2 7.8 -0.5 -2.8 1.5 -0.5 -0.8
High blood pressure 2.5 7.1 14.2 2.1 2.9 -3.8 2.8 -0.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 3.8 1.2 0.9 -1.5 1.1 1.9
Multivitamins +/- minerals 0.2 0.3 0.4 0.6 0.5 -0.4 0.4 -0.6
Stomach or abdominal pain in last month 0.1 0.1 0.3 -0.1 -0.2 -0.1 -0.3 0.6
Supplements: Glucosamine 1.6 2.1 5.9 1.1 -1.8 0.0 0.5 -2.4
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 1.9 1.3 1.3 0.0 0.4 -1.4
Medication: Atenolol 1.0 1.2 1.9 1.0 1.4 -1.1 1.4 -0.4
Medication: Levothyroxine sodium 0.6 0.9 3.6 -0.1 -0.2 1.0 -0.3 -1.9
Sitting height 0.6 4.3 9.4 2.0 1.4 -1.1 2.2 -3.1
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.8 -0.3 0.0 0.1 0.7
High blood pressure (mother) 2.5 3.5 6.7 0.1 1.3 -2.0 2.6 -2.2
Body mass index (BMI) 1.4 6.0 9.5 3.1 1.6 -2.9 2.8 -1.3
Impedance of leg (left) 0.1 0.4 0.8 0.1 0.8 -0.6 0.5 0.9
Leg predicted mass (left) 1.0 5.2 8.6 2.1 0.9 -2.3 2.9 -2.6
Trunk fat mass 2.9 12.6 18.4 4.3 2.3 -4.2 4.1 -2.2
Waist circumference 3.2 11.6 16.7 3.9 2.6 -4.0 4.1 -1.6
Number of incorrect matches in round 0.5 0.8 1.3 1.1 0.2 0.8 -1.2 -0.7
Past tobacco smoking 0.3 0.6 2.1 1.5 -0.2 -0.7 0.7 -0.1
Alcohol usually taken with meals 0.4 0.7 2.5 -0.0 -1.6 0.5 -0.7 0.3
Nervous feelings 0.8 1.4 3.5 0.2 -1.4 1.9 -0.2 -1.3
Frequency of tenseness / restlessness in last 2 weeks 4.9 7.7 12.2 -1.5 -3.5 3.4 -3.5 0.4
Hearing difficulty/problems with background noise 0.3 0.5 1.3 0.9 0.1 0.5 -0.6 -1.1
Hair/balding pattern: Pattern 2 2.4 3.1 8.3 -2.2 -2.9 0.9 -1.2 -0.2
Had menopause 0.2 0.3 0.6 -0.2 -0.4 0.8 -0.7 -0.2
Had other major operations 1.0 1.2 2.4 1.1 0.5 -1.4 1.6 0.7
Forced vital capacity (FVC) 0.4 1.5 3.0 -1.6 -0.9 1.1 0.1 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 5.7 2.4 1.0 -1.0 0.9 -0.5
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 4.8 1.0 -2.2 -0.0 -1.2 1.5
Qualifications: None of the above 0.8 1.7 3.3 -0.9 -0.2 1.8 -1.6 -1.3
Financial difficulties in last 2 years 0.8 1.1 2.0 -0.4 -1.3 1.2 -1.4 -0.4
Mouth/teeth dental problems 0.5 0.7 2.3 -0.5 1.5 -0.6 0.0 0.8
Heart attack 1.5 1.9 3.8 1.9 0.2 -1.6 1.7 0.1
Allergy 0.3 0.6 2.3 -0.2 0.5 0.7 0.1 -1.5
Pain all over the body in last month 1.7 1.8 4.3 -2.1 0.4 1.4 -1.6 0.2
Diabetes (self-reported) 3.0 4.6 10.7 0.2 2.1 -2.8 3.3 -0.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.7 1.0 -0.0 -0.5 0.4 -1.7
Medication: Ramipril 6.1 7.8 14.5 1.7 2.5 -3.6 3.8 1.7
Medication: Simvastatin 2.8 4.1 7.2 2.4 0.6 -2.7 2.6 -0.7
Fluid intelligence score 1.9 4.0 7.7 -0.1 2.2 -2.6 2.8 -0.9
Illnesses of siblings 2.1 3.0 11.8 -1.6 0.0 -0.7 0.5 3.4
Neuroticism score 0.5 1.0 3.2 0.1 -0.3 1.8 -0.9 -0.8
Weight 2.3 11.1 15.8 3.8 2.3 -3.8 4.0 -2.3
Impedance of arm (right) 0.0 0.1 0.4 -0.1 -0.7 0.2 -0.4 0.1
Arm fat percentage (right) 1.9 7.4 11.4 3.4 1.6 -3.3 3.1 -1.6
Trunk fat-free mass 1.1 6.5 10.2 2.2 2.0 -2.6 3.2 -2.6
Hip circumference 1.8 7.8 13.0 3.3 0.8 -2.9 3.6 -2.5
Time employed in main current job 0.3 0.3 0.7 0.5 -0.2 0.8 0.7 -0.6
Alcohol intake versus 10 years previously 0.3 0.4 1.3 -0.2 -0.8 -1.1 0.5 -0.2
Father’s age at death 1.7 2.3 3.6 -1.5 -1.4 1.9 -1.8 0.3
Worrier / anxious feelings 0.3 0.5 1.3 -1.1 -0.9 0.7 0.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 8.9 -1.7 -1.8 3.0 -2.1 -1.6
Falls in the last year 0.8 1.0 2.8 0.2 -0.6 1.1 -0.8 -1.7
Hair/balding pattern: Pattern 3 0.7 1.0 3.8 0.3 -0.2 1.9 -1.1 0.2
Number of live births 1.9 2.6 4.6 1.9 2.0 -2.1 0.9 0.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 4.6 -1.0 0.4 -1.3 2.1 -0.5
Pulse rate 1.0 1.7 2.8 1.2 1.3 -1.5 1.7 0.6
Happiness 0.4 0.5 1.7 0.8 -1.3 -0.1 -0.3 -0.1
Noisy workplace 1.6 1.9 3.7 -0.2 1.2 -1.8 1.9 1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.2 0.3 1.6 -1.8 1.4 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.1 -0.3 0.1 -0.0 0.4 1.0
Mouth/teeth dental problems: Dentures 1.9 3.1 5.2 1.4 -2.3 2.0 -1.1 -1.8
Asthma 0.9 1.7 4.8 -0.3 -2.2 1.4 -1.3 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.5 5.3 0.6 -1.2 2.1 -2.3 -0.7
Medication: Cholesterol lowering 1.7 2.6 5.4 1.9 0.6 -1.9 2.3 0.3
Depression (self-reported) 1.2 1.5 2.6 -0.6 -1.5 1.5 -1.6 0.3
Medication: Lansoprazole 0.6 0.7 1.9 0.4 -0.2 1.4 -0.4 -1.1
Prospective memory result 0.4 0.5 0.7 0.8 0.6 0.8 -0.5 -0.8
Lung cancer (father) 0.6 0.7 1.7 1.0 -0.5 -0.6 0.5 1.3
Illnesses of mother 1.1 1.4 5.4 -0.6 -0.5 0.7 -0.6 2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 4.7 -0.5 0.5 -1.5 2.2 -0.3
Pulse wave Arterial Stiffness index 1.2 1.4 2.7 -1.3 -0.2 -1.6 0.8 1.5
Impedance of arm (left) 0.2 0.8 1.2 -1.0 -1.1 1.0 -0.8 -0.3
Arm fat mass (right) 2.2 9.2 13.7 3.5 1.9 -3.7 3.6 -1.9
Trunk predicted mass 1.1 6.5 10.4 2.2 2.0 -2.5 3.2 -2.6
Standing height 0.7 6.7 10.7 2.1 1.9 -2.6 3.3 -2.9
Length of working week for main job 1.0 1.1 3.2 -1.8 0.9 1.2 -0.4 -0.1
Exposure to tobacco smoke at home 0.3 0.3 0.7 -0.5 -0.8 -0.7 0.5 -0.0
Breastfed as a baby 0.5 0.7 3.0 0.3 1.7 -0.3 0.4 0.3
Tense / ‘highly strung’ 0.7 1.1 2.9 0.6 -0.5 1.7 -1.1 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.3 -0.1 -1.0 1.1 -0.9 -0.8
Hair/balding pattern: Pattern 4 0.9 2.1 5.2 2.3 1.6 -1.1 0.5 -1.2
Birth weight of first child 0.8 1.5 5.4 -2.3 0.0 -1.0 0.1 1.1
Peak expiratory flow (PEF) 0.7 1.6 3.5 -1.0 0.1 -1.8 1.9 -0.3
Pulse wave reflection index 1.5 1.8 3.6 -1.9 -0.9 -1.1 -0.0 1.9
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 -0.3 -0.5 -0.6 -0.1 0.8
Loud music exposure frequency 0.3 0.3 0.6 -0.6 -0.2 0.5 -0.8 0.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.8 0.6 -0.6 0.1 0.3
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.5 1.5 1.2 -1.3 1.9 -0.2
Blood clot in the leg (DVT) 0.3 0.4 0.9 0.3 0.3 -0.9 0.5 -0.9
Medication: Paracetamol 3.5 5.8 11.8 -0.4 -1.7 3.4 -3.2 -1.9
Headache pain in last month 0.5 0.9 1.8 -0.7 -1.2 0.8 0.2 -1.3
Medication for cholesterol, blood pressure or diabetes 3.1 5.2 8.0 -2.5 -2.4 2.8 -2.4 -0.4
Glaucoma (self-reported) 0.1 0.1 0.5 -0.7 -0.3 0.1 -0.3 0.2
Gout (self-reported) 0.7 0.9 1.8 1.1 0.3 0.9 -1.4 -0.8
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 5.8 0.6 -0.8 1.8 -1.2 -2.4
Medication: Amlodipine 2.4 3.4 7.5 0.6 1.8 -2.7 2.0 1.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.8 -0.7 -0.7 0.9 -0.9 0.1
Birth weight 2.8 6.1 15.1 1.6 1.3 -3.9 3.1 1.1
Chronic bronchitis/emphysema (mother) 1.4 1.7 4.1 -0.5 -0.3 2.0 -1.3 -1.5
High blood pressure (siblings) 3.0 4.3 10.2 3.2 2.0 -1.1 1.3 -2.1
Forced vital capacity (FVC), Best measure 0.5 1.7 2.6 -1.5 -1.4 1.2 -0.0 -1.6
Body fat percentage 2.9 11.4 18.7 4.3 2.3 -4.1 3.8 -1.5
Leg fat percentage (right) 3.0 10.8 16.7 3.6 2.9 -4.1 3.9 -0.7
Arm fat-free mass (right) 1.4 7.0 12.5 2.4 1.9 -2.8 3.5 -2.4
Exposure to tobacco smoke outside home 0.2 0.2 0.6 0.0 0.3 0.0 0.7 -0.7
Comparative body size at age 10 0.5 1.3 2.4 1.3 1.3 -0.9 0.2 1.5
Number of full brothers 0.4 0.5 1.6 1.2 0.1 -0.4 -0.4 -0.9
Worry too long after embarrassment 0.2 0.3 0.6 0.3 -0.3 0.7 -0.3 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 4.9 0.2 -0.6 1.5 -2.2 0.3
Wheeze or whistling in the chest in last year 0.1 0.2 1.0 1.0 -0.3 -0.2 -0.2 0.2
Number of children fathered 1.5 1.6 5.0 0.1 1.4 -0.2 -1.1 2.2
Reason for reducing amount of alcohol drunk: Health precaution 2.3 2.6 3.9 1.3 1.3 -1.9 1.6 2.0
Age at first live birth 1.2 2.1 4.4 -1.2 1.6 -1.3 0.9 2.1
Pulse wave peak to peak time 1.5 1.8 3.2 1.6 0.4 1.6 -0.6 -1.8
Health satisfaction 0.5 0.7 1.7 0.7 -1.0 0.0 0.4 -1.3
Shortness of breath walking on level ground 0.9 1.0 3.1 -0.2 -0.2 -0.2 1.8 -1.4
Qualifications: College or University degree 1.1 3.3 5.7 0.6 2.0 -2.4 1.6 2.0
Eye problems/disorders: None of the above 0.4 0.5 1.6 -0.2 1.2 0.1 0.3 0.8
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.4 1.0 1.2 -1.0 0.8 -0.2
Emphysema/chronic bronchitis 1.2 1.4 2.9 -0.5 -1.7 1.3 -1.1 -1.0
Medication for pain relief, constipation, heartburn 1.4 2.4 5.2 -0.6 1.3 -2.3 1.4 1.8
Neck or shoulder pain in last month 0.4 0.5 1.8 -0.2 0.3 0.9 -0.0 -1.3
Medication: Blood pressure 4.4 7.7 12.4 2.2 3.4 -3.5 3.1 0.1
Angina (self-reported) 0.4 0.5 1.6 0.3 -0.8 0.1 1.2 -0.2
Migraine (self-reported) 0.5 0.7 1.6 -0.1 0.7 -0.5 1.3 -1.0
Medication: Ibuprofen 1.2 1.4 2.6 0.9 -1.2 1.3 -1.6 -0.6
Medication: Allopurinol 0.6 0.8 1.6 0.7 1.0 0.7 -1.2 -0.6
Medication: Omeprazole 1.4 1.7 5.9 -0.2 -2.4 0.8 -1.4 -0.1
Medication: Seretide 50 evohaler 2.1 2.5 5.4 -0.6 -1.8 2.3 -1.6 1.0
Mean time to correctly identify matches 2.0 3.8 7.3 2.7 2.2 -2.2 1.2 0.3
Heart disease (mother) 0.4 0.5 1.9 0.4 -0.4 -0.3 0.4 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.9 -0.3 -1.0 1.5 -1.7 1.1
Whole body fat mass 3.1 12.9 18.5 4.2 2.5 -4.3 4.3 -1.9
Leg fat mass (right) 3.0 11.6 17.8 3.7 2.6 -4.2 4.2 -1.4
Arm predicted mass (right) 1.3 6.8 11.4 2.4 1.9 -2.8 3.4 -2.2
Pulse rate, automated reading 1.1 3.6 6.3 2.5 2.1 -1.9 1.6 1.1
Alcohol intake frequency. 0.2 0.5 1.1 0.6 -0.5 -1.1 0.3 -1.0
Comparative height size at age 10 1.1 6.0 8.0 2.1 2.6 -2.2 2.8 -2.5
Number of full sisters 1.0 1.2 2.7 0.9 -0.6 0.7 -1.2 -1.6
Suffer from ‘nerves’ 0.2 0.4 1.6 0.1 0.5 -0.2 1.2 -0.1
Overall health rating 0.8 1.7 3.6 -0.0 -0.4 1.6 -1.4 -1.9
Chest pain or discomfort 0.5 0.8 1.8 1.4 -0.6 0.6 -0.4 -1.1
Had major operations 0.8 1.0 3.1 0.9 -1.8 0.8 -0.5 -0.3
Age at last live birth 1.4 2.0 3.1 -1.0 1.8 -1.2 1.3 1.7
Family relationship satisfaction 0.6 0.8 2.5 1.6 0.3 -1.0 -0.1 0.6
Leg pain on walking 0.3 0.4 0.8 -0.4 0.0 -0.7 0.5 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.6 1.2 -1.2 -1.3 0.6 0.9
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.4 -1.9 0.2 0.9 -0.5 0.2
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 5.8 0.8 2.4 -0.2 0.2 -0.7
Medication: Aspirin 1.2 1.6 3.7 1.1 0.9 -1.4 1.9 0.7
Supplements: Vitamin C 1.8 2.2 4.1 2.0 -0.2 -1.3 2.0 -1.1
Knee pain experienced in last month 0.3 0.5 1.1 -0.4 -0.1 -1.0 1.0 0.5
Hypertension (Self-reported) 2.7 7.5 15.4 2.0 3.3 -3.9 2.7 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 2.2 -0.1 -1.5 1.0 -1.2 0.6
Illnesses of father: Heart disease 2.7 3.7 9.6 -0.5 0.3 2.0 -2.1 -3.1
Illnesses of siblings: Diabetes 0.6 0.8 1.9 1.4 -0.0 -1.3 0.0 -0.3
Smoking status: Previous 0.5 0.8 2.1 -1.5 0.7 0.6 -0.9 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.2 0.3 0.4 -1.1 1.1 -0.4
Whole body fat-free mass 1.1 6.3 10.4 2.3 1.6 -2.5 3.2 -2.6
Leg fat-free mass (right) 0.8 4.1 6.5 2.0 0.8 -2.0 2.5 -2.4
Arm fat percentage (left) 1.7 6.8 10.8 3.3 1.4 -3.0 3.0 -1.9
Average weekly red wine intake 0.2 0.2 0.6 -0.8 0.2 -0.4 -0.3 0.6
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.0 -0.7 -1.7 -0.5 1.1 -0.9
Mood swings 0.6 1.1 2.7 0.3 -0.7 0.8 -1.7 1.2
Loneliness, isolation 0.6 0.8 1.7 0.7 -0.7 1.1 -1.3 0.6
Long-standing illness, disability or infirmity 0.7 1.1 2.5 0.7 1.3 -1.6 0.9 0.3
Ever had bowel cancer screening 1.6 1.8 4.1 1.7 0.1 1.4 -2.0 -0.5
Diabetes diagnosed by doctor 3.6 5.9 11.7 0.8 2.5 -3.3 3.4 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.5 -1.9 -0.9 0.2 -0.2 1.2
Friendships satisfaction 1.1 1.4 4.1 2.0 -0.5 -1.3 0.7 0.5
Qualifications: nursing, teaching 0.6 0.9 2.3 0.7 1.2 -0.5 -0.2 1.5
Commuting to job workplace: Walk 1.8 1.9 3.5 1.8 -0.4 1.0 -1.9 -1.2
Eye problems/disorders: Cataract 1.1 1.2 3.4 -0.5 -1.8 1.0 -0.9 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 -0.9 -0.3 0.1 -0.8 0.9
Medication for cholesterol 2.6 3.9 9.2 -1.9 -0.7 3.0 -2.5 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 4.4 0.2 1.1 1.1 -2.1 1.2
Back pain experienced in last month 0.9 1.3 3.0 1.7 1.0 0.1 0.1 -1.6
Mineral and other dietary supplements 2.4 3.2 5.1 -1.9 -1.0 1.9 -2.3 1.7
Breast cancer (self-reported) 1.0 1.2 2.1 -1.4 -0.2 -0.5 1.4 1.3
Asthma (self-reported) 1.0 2.0 5.2 -0.4 -2.3 1.5 -1.4 -0.3
Osteoporosis (self-reported) 0.8 1.0 2.0 1.4 -0.7 1.0 -1.2 -0.5
Osteoarthritis (self-reported) 0.7 0.9 3.7 0.0 -0.6 0.4 -0.0 -1.9
Medication: Aspirin 1.9 2.4 4.7 1.3 1.6 -1.7 2.2 0.6
Medication: Gliclazide 3.5 4.0 8.5 1.3 2.2 -1.9 2.9 -1.1
Illnesses of father: None of the above (group 1) 0.3 0.3 0.8 0.8 -0.9 -0.1 0.2 0.3
Smoking status: Current 0.1 0.2 0.9 -0.2 -0.4 -0.0 0.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.1 8.7 19.3 0.3 3.1 -3.8 4.4 0.7
Whole body water mass 1.0 5.9 9.8 2.2 1.5 -2.5 3.1 -2.5
Leg predicted mass (right) 0.7 3.9 6.1 1.9 0.8 -1.9 2.5 -2.4
Arm fat mass (left) 2.3 9.5 14.1 3.5 1.9 -3.7 3.8 -2.0
Number of self-reported non-cancer illnesses 0.5 0.9 2.9 1.7 -0.3 -0.0 -0.3 -1.3
Average weekly champagne plus white wine intake 1.0 1.4 3.7 1.0 0.4 -1.2 1.9 -0.9
Miserableness 1.4 2.3 4.4 -0.4 -2.1 2.0 -1.5 -1.0
Guilty feelings 0.2 0.4 0.9 0.8 0.9 0.2 -0.1 0.6
Wears glasses or contact lenses 0.5 0.6 2.1 -0.2 -0.7 0.8 -0.1 -1.4
Ever taken oral contraceptive pill 1.5 1.7 5.2 2.3 0.6 -0.3 -0.3 1.6
Hearing aid user 0.4 0.4 1.1 0.7 -0.2 0.6 -1.1 -0.6
Mother’s age at death 0.7 0.8 2.4 -0.6 -0.2 1.1 -1.5 -0.4
Financial situation satisfaction 1.4 1.8 3.6 -0.1 -1.9 1.4 -1.8 0.1
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.4 -1.5 0.3 0.9 -0.6 -0.7
Commuting to job workplace: Public transport 0.7 0.8 2.1 0.4 0.0 1.4 -0.6 -1.2
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 -0.7 -0.5 0.2 -0.3 0.1
Medication: Blood pressure 2.7 5.1 9.7 2.2 2.2 -3.1 2.4 -0.7
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 0.8 0.5 0.2 -0.9 -0.5
Supplements: Fish oil (including cod liver oil) 1.7 2.3 3.5 1.5 0.8 -1.4 1.9 -1.7
High cholesterol (Self-reported) 0.8 1.4 5.3 2.3 -0.2 -1.1 0.5 0.6
Medication: Bendroflumethiazide 3.6 5.5 9.9 3.2 1.9 -2.7 2.1 -1.4
Medication: Paracetamol 2.5 3.9 7.3 -0.2 -1.8 2.7 -2.5 -1.6
Medication: Lisinopril 1.4 1.8 4.5 0.5 1.5 -2.1 1.3 0.2
Medication: Atorvastatin 0.7 0.9 2.1 0.9 0.3 -1.4 0.9 0.8
Illnesses of father: High blood pressure 0.3 0.3 0.8 -0.5 0.1 0.6 -0.9 -0.4
Alcohol drinker status: Never 0.7 0.9 1.4 -1.2 -0.5 1.2 -1.0 -0.5
Ever smoked 0.4 0.6 1.9 -1.4 -0.4 0.4 -0.5 0.9
Basal metabolic rate 1.4 7.5 12.5 2.6 1.7 -2.9 3.5 -2.6
Leg fat percentage (left) 2.7 9.7 14.3 3.7 2.7 -3.8 3.5 -0.6
Arm fat-free mass (left) 1.4 7.3 12.0 2.6 1.9 -2.9 3.5 -2.3
Number of operations (self-reported) 1.1 1.6 3.3 0.6 -1.8 1.4 -1.3 -0.8
Average weekly beer plus cider intake 0.4 0.5 1.6 -0.4 1.3 0.1 0.1 -0.9
Irritability 4.1 7.0 16.4 -0.0 -2.4 3.6 -4.0 -0.4
Risk taking 1.9 2.8 4.9 0.4 1.9 -2.1 0.8 2.2
Ever had prostate specific antigen (PSA) test 3.0 3.5 4.7 1.9 2.1 -2.2 2.0 -0.5
Fractured/broken bones in last 5 years 0.9 1.2 2.3 -1.5 -1.3 0.7 -0.3 1.1
Age started oral contraceptive pill 1.5 1.8 3.8 1.8 0.6 1.0 -0.9 -1.9
Diastolic blood pressure, automated reading 6.0 18.6 33.5 4.1 3.5 -5.8 5.3 1.6
Ever depressed for a whole week 1.6 1.9 4.2 1.7 -2.0 -1.4 0.0 0.7
Unable to work because of sickness or disability 1.3 1.7 5.1 -2.3 -0.9 1.3 -0.2 -1.0
Commuting to job workplace: Cycle 0.6 0.8 2.0 -0.9 1.4 -0.3 0.2 0.9
Myopia 1.3 1.9 5.2 0.5 1.3 -2.3 1.4 0.5
Vascular/heart problems diagnosed by doctor 2.1 5.6 11.0 -1.7 -2.4 3.3 -2.9 0.3
Cholesterol lowering medication 2.6 3.9 7.9 2.0 0.0 -2.8 2.6 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.8 -0.2 -1.9 0.7 -1.0 -0.6
Pain experienced in last month 0.4 0.6 1.8 1.4 0.2 -0.6 -0.4 0.9
Supplements: Calcium 1.0 1.1 2.3 -0.3 -1.5 1.4 -0.4 -1.0
Basal cell carcinoma (self-reported) 1.0 1.2 2.7 -0.4 -0.2 -1.1 1.6 1.3
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.6 2.4 0.2 -1.5 1.6 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 -0.0 0.2 -0.7 0.3 -0.9
Heart disease (siblings) 2.1 2.5 9.4 0.9 -0.5 1.3 -0.7 -3.1
Alcohol drinker status: Previous 0.4 0.5 1.7 0.2 0.0 -0.1 0.9 -1.3
Pack years of smoking 0.6 0.9 2.1 1.5 0.5 -1.1 1.1 -0.3
Impedance of whole body 0.0 0.1 0.4 -0.2 -0.2 -0.0 -0.1 0.6
Leg fat mass (left) 2.9 11.2 16.1 3.8 2.7 -4.0 4.0 -1.5
Arm predicted mass (left) 1.6 8.4 13.7 2.9 2.1 -3.2 3.7 -2.2