[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) :

chr3:48,012,797-50,800,146

Best TWAS P=2.89e-12 · Best GWAS P=7.54e-12 conditioned to 0.051

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RHOA 0.03 0.02 blup 294 0.02 1.0e-03 -5.0 -6.2 5.0e-10 -0.62 0.38 0.38 FALSE
2 CommonMind Brain Pre-frontal Cortex RNF123 0.14 0.10 blup 324 0.12 4.7e-14 3.9 5.8 6.8e-09 0.79 0.65 0.35 FALSE
3 GTEx Adipose Subcutaneous KLHDC8B 0.04 0.01 lasso 5 0.00 1.3e-01 -4.5 -5.3 9.9e-08 -0.47 0.39 0.06 FALSE
4 GTEx Adipose Visceral Omentum LAMB2 0.05 0.00 lasso 5 0.00 7.0e-01 -3.9 -5.3 1.1e-07 -0.50 0.15 0.20 FALSE
5 GTEx Brain Cerebellar Hemisphere AMT 0.40 0.42 enet 23 0.42 4.1e-12 -5.0 5.9 2.7e-09 0.53 0.99 0.00 FALSE
6 GTEx Brain Cerebellar Hemisphere MST1R 0.30 0.08 enet 25 0.10 1.8e-03 4.3 6.0 1.7e-09 0.75 0.20 0.33 FALSE
7 GTEx Brain Cerebellar Hemisphere FAM212A 0.25 0.17 lasso 21 0.20 8.1e-06 -4.2 6.0 1.5e-09 0.83 0.10 0.80 FALSE
8 GTEx Brain Cerebellum AMT 0.37 0.36 lasso 18 0.34 8.2e-11 -5.1 5.2 1.7e-07 0.45 0.99 0.01 FALSE
9 GTEx Brain Nucleus accumbens basal ganglia NICN1-AS1 0.23 0.09 lasso 13 0.05 2.1e-02 -5.1 -5.5 3.1e-08 -0.58 0.14 0.27 FALSE
10 GTEx Brain Putamen basal ganglia AMT 0.11 0.03 lasso 14 0.05 2.4e-02 -4.7 6.2 5.7e-10 0.66 0.06 0.43 FALSE
11 GTEx Brain Putamen basal ganglia NCKIPSD 0.23 0.23 enet 14 0.22 5.4e-06 -4.5 5.3 1.2e-07 0.54 0.24 0.64 FALSE
12 GTEx Cells Transformed fibroblasts NICN1 0.06 0.06 lasso 7 0.05 1.6e-04 -4.7 5.4 7.2e-08 0.42 0.82 0.03 FALSE
13 GTEx Cells Transformed fibroblasts GPX1 0.07 0.10 lasso 5 0.10 1.2e-07 -5.0 -5.5 3.8e-08 -0.49 0.97 0.03 FALSE
14 GTEx Colon Transverse RBM6 0.29 0.33 enet 43 0.36 4.6e-18 -4.2 -5.3 1.5e-07 -0.63 1.00 0.00 FALSE
15 GTEx Colon Transverse AMT 0.11 0.18 lasso 7 0.18 8.7e-09 -5.1 5.5 4.8e-08 0.47 0.94 0.05 FALSE
16 GTEx Colon Transverse NCKIPSD 0.13 0.09 lasso 7 0.11 8.0e-06 -4.2 5.4 7.3e-08 0.59 0.14 0.85 FALSE
17 GTEx Colon Transverse GPX1 0.11 0.01 lasso 5 0.01 8.8e-02 -4.4 -5.7 1.0e-08 -0.70 0.07 0.63 FALSE
18 GTEx Esophagus Gastroesophageal Junction TCTA 0.17 0.06 lasso 15 0.03 3.8e-02 -5.3 5.8 5.4e-09 0.61 0.35 0.17 FALSE
19 GTEx Esophagus Mucosa RNF123 0.07 0.03 enet 9 0.04 1.8e-03 3.7 5.2 2.6e-07 0.86 0.08 0.87 FALSE
20 GTEx Heart Atrial Appendage QRICH1 0.06 0.01 enet 7 0.01 1.2e-01 -4.4 -5.3 9.3e-08 -0.52 0.20 0.12 FALSE
21 GTEx Heart Atrial Appendage RHOA-IT1 0.07 0.04 lasso 3 0.04 4.4e-03 -4.3 -5.4 6.0e-08 -0.62 0.18 0.38 FALSE
22 GTEx Heart Left Ventricle AMT 0.07 0.02 lasso 7 0.02 4.6e-02 6.4 7.0 2.9e-12 0.82 0.06 0.73 TRUE
23 GTEx Heart Left Ventricle NICN1-AS1 0.09 0.00 enet 8 0.01 1.0e-01 6.8 6.7 2.2e-11 0.83 0.04 0.78 FALSE
24 GTEx Lung TCTA 0.09 0.01 enet 10 0.03 3.3e-03 6.4 6.2 5.4e-10 0.69 0.03 0.58 FALSE
25 GTEx Nerve Tibial KLHDC8B 0.05 0.03 lasso 13 0.02 7.1e-03 -4.5 -5.2 1.7e-07 -0.55 0.42 0.19 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic NICN1 0.07 0.09 lasso 6 0.10 4.2e-06 -5.0 5.3 9.4e-08 0.43 0.90 0.03 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic NICN1-AS1 0.06 0.11 lasso 3 0.10 4.3e-06 -5.1 5.3 1.1e-07 0.42 0.92 0.02 FALSE
28 GTEx Skin Sun Exposed Lower leg GPX1 0.04 0.05 lasso 3 0.04 2.9e-04 -5.1 -5.7 1.5e-08 -0.50 0.61 0.09 FALSE
29 GTEx Skin Sun Exposed Lower leg NICN1-AS1 0.09 0.08 lasso 7 0.06 4.6e-06 -5.0 5.2 2.0e-07 0.43 1.00 0.00 FALSE
30 GTEx Stomach GPX1 0.11 0.15 lasso 3 0.14 2.4e-07 -5.1 -5.3 1.4e-07 -0.45 0.96 0.01 FALSE
31 GTEx Testis AMT 0.19 0.14 enet 25 0.20 3.7e-09 -4.8 5.5 3.8e-08 0.50 1.00 0.00 FALSE
32 GTEx Testis TRAIP 0.14 0.08 enet 22 0.08 1.9e-04 6.8 6.8 8.5e-12 0.86 0.01 0.96 FALSE
33 GTEx Thyroid TCTA 0.04 0.02 lasso 4 0.01 2.4e-02 -4.7 6.1 8.1e-10 0.59 0.21 0.63 FALSE
34 GTEx Thyroid RHOA-IT1 0.05 0.05 lasso 5 0.04 5.2e-04 6.4 -6.3 2.3e-10 -0.76 0.11 0.83 FALSE
35 GTEx Uterus NCKIPSD 0.13 0.10 lasso 4 0.22 2.6e-05 3.7 5.7 1.6e-08 0.53 0.09 0.28 FALSE
36 GTEx Whole Blood AMT 0.07 0.08 enet 37 0.09 1.1e-08 -5.1 6.1 9.2e-10 0.60 0.98 0.02 FALSE
37 GTEx Whole Blood GPX1 0.05 0.06 enet 15 0.05 1.5e-05 -5.0 -5.3 1.2e-07 -0.46 0.99 0.00 FALSE
38 NTR Blood GMPPB 0.01 0.00 bslmm 311 0.00 9.6e-03 -5.0 -5.3 1.4e-07 -0.59 0.11 0.15 FALSE
39 ROSMAP Brain Pre-frontal Cortex FAM212A 0.07 0.02 bslmm 286 0.03 5.0e-05 6.8 -6.7 2.3e-11 -0.82 0.02 0.98 FALSE
40 ROSMAP Brain Pre-frontal Cortex KLHDC8B 0.01 0.01 blup 255 0.01 1.0e-02 -4.5 -6.1 1.1e-09 -0.65 0.09 0.35 FALSE
41 ROSMAP Brain Pre-frontal Cortex BSN-AS2 0.07 0.10 lasso 6 0.09 3.5e-12 6.4 -6.4 1.3e-10 -0.83 0.11 0.89 FALSE
42 YFS Blood AMT 0.15 0.18 lasso 12 0.19 1.6e-60 -5.0 5.6 2.5e-08 0.49 1.00 0.00 FALSE
43 YFS Blood DAG1 0.01 0.00 bslmm 305 0.00 2.6e-02 -4.8 -5.3 1.1e-07 -0.69 0.02 0.24 FALSE
44 YFS Blood NICN1 0.15 0.20 blup 283 0.22 3.5e-70 -5.0 -5.4 6.9e-08 -0.49 1.00 0.00 FALSE
45 The Cancer Genome Atlas Breast Invasive Carcinoma DALRD3 0.03 0.02 lasso 2 0.02 7.3e-06 -4.5 5.3 9.8e-08 0.60 0.01 0.99 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma RBM6 0.03 0.04 blup 79 0.05 9.5e-10 -4.2 -5.1 2.6e-07 -0.62 0.11 0.84 FALSE
47 The Cancer Genome Atlas Colon Adenocarcinoma USP4 0.06 0.04 lasso 5 0.05 5.3e-04 -4.9 -5.2 2.0e-07 -0.48 0.15 0.33 FALSE
48 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC36 0.11 0.12 enet 8 0.11 8.2e-13 -4.8 5.1 2.9e-07 0.52 0.03 0.97 FALSE
49 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma GMPPB 0.09 0.05 enet 7 0.04 1.5e-03 -4.8 -5.1 3.0e-07 -0.69 0.01 0.51 FALSE
50 The Cancer Genome Atlas Brain Lower Grade Glioma MST1R 0.08 0.07 enet 10 0.09 2.6e-10 4.3 6.0 2.0e-09 0.77 0.23 0.77 FALSE
51 The Cancer Genome Atlas Lung Adenocarcinoma AMT 0.02 0.00 blup 25 0.01 5.4e-02 -5.0 6.1 1.4e-09 0.57 0.02 0.33 FALSE
52 The Cancer Genome Atlas Lung Adenocarcinoma CCDC36 0.06 0.05 lasso 5 0.05 3.4e-06 -5.3 5.2 2.0e-07 0.56 0.01 0.99 FALSE
53 The Cancer Genome Atlas Pancreatic Adenocarcinoma CAMKV 0.07 0.05 enet 9 0.06 2.3e-03 3.7 5.8 5.7e-09 0.87 0.01 0.74 FALSE
54 The Cancer Genome Atlas Testicular Germ Cell Tumors RBM6 0.16 0.12 blup 79 0.09 4.4e-04 -4.2 -5.5 3.3e-08 -0.64 0.09 0.83 FALSE
55 The Cancer Genome Atlas Thyroid Carcinoma TCTA 0.04 0.04 blup 24 0.03 3.6e-04 6.4 6.6 3.4e-11 0.74 0.01 0.97 FALSE