[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr3:48,012,797-50,800,146

Best TWAS P=2.89e-12 · Best GWAS P=7.54e-12 conditioned to 0.051

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RHOA	0.03	0.02	blup	294	0.02	1.0e-03	-5.0	-6.2	5.0e-10	-0.62	0.38	0.38	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	3.9	5.8	6.8e-09	0.79	0.65	0.35	FALSE
3	GTEx	Adipose Subcutaneous	KLHDC8B	0.04	0.01	lasso	5	0.00	1.3e-01	-4.5	-5.3	9.9e-08	-0.47	0.39	0.06	FALSE
4	GTEx	Adipose Visceral Omentum	LAMB2	0.05	0.00	lasso	5	0.00	7.0e-01	-3.9	-5.3	1.1e-07	-0.50	0.15	0.20	FALSE
5	GTEx	Brain Cerebellar Hemisphere	AMT	0.40	0.42	enet	23	0.42	4.1e-12	-5.0	5.9	2.7e-09	0.53	0.99	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	MST1R	0.30	0.08	enet	25	0.10	1.8e-03	4.3	6.0	1.7e-09	0.75	0.20	0.33	FALSE
7	GTEx	Brain Cerebellar Hemisphere	FAM212A	0.25	0.17	lasso	21	0.20	8.1e-06	-4.2	6.0	1.5e-09	0.83	0.10	0.80	FALSE
8	GTEx	Brain Cerebellum	AMT	0.37	0.36	lasso	18	0.34	8.2e-11	-5.1	5.2	1.7e-07	0.45	0.99	0.01	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	NICN1-AS1	0.23	0.09	lasso	13	0.05	2.1e-02	-5.1	-5.5	3.1e-08	-0.58	0.14	0.27	FALSE
10	GTEx	Brain Putamen basal ganglia	AMT	0.11	0.03	lasso	14	0.05	2.4e-02	-4.7	6.2	5.7e-10	0.66	0.06	0.43	FALSE
11	GTEx	Brain Putamen basal ganglia	NCKIPSD	0.23	0.23	enet	14	0.22	5.4e-06	-4.5	5.3	1.2e-07	0.54	0.24	0.64	FALSE
12	GTEx	Cells Transformed fibroblasts	NICN1	0.06	0.06	lasso	7	0.05	1.6e-04	-4.7	5.4	7.2e-08	0.42	0.82	0.03	FALSE
13	GTEx	Cells Transformed fibroblasts	GPX1	0.07	0.10	lasso	5	0.10	1.2e-07	-5.0	-5.5	3.8e-08	-0.49	0.97	0.03	FALSE
14	GTEx	Colon Transverse	RBM6	0.29	0.33	enet	43	0.36	4.6e-18	-4.2	-5.3	1.5e-07	-0.63	1.00	0.00	FALSE
15	GTEx	Colon Transverse	AMT	0.11	0.18	lasso	7	0.18	8.7e-09	-5.1	5.5	4.8e-08	0.47	0.94	0.05	FALSE
16	GTEx	Colon Transverse	NCKIPSD	0.13	0.09	lasso	7	0.11	8.0e-06	-4.2	5.4	7.3e-08	0.59	0.14	0.85	FALSE
17	GTEx	Colon Transverse	GPX1	0.11	0.01	lasso	5	0.01	8.8e-02	-4.4	-5.7	1.0e-08	-0.70	0.07	0.63	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	TCTA	0.17	0.06	lasso	15	0.03	3.8e-02	-5.3	5.8	5.4e-09	0.61	0.35	0.17	FALSE
19	GTEx	Esophagus Mucosa	RNF123	0.07	0.03	enet	9	0.04	1.8e-03	3.7	5.2	2.6e-07	0.86	0.08	0.87	FALSE
20	GTEx	Heart Atrial Appendage	QRICH1	0.06	0.01	enet	7	0.01	1.2e-01	-4.4	-5.3	9.3e-08	-0.52	0.20	0.12	FALSE
21	GTEx	Heart Atrial Appendage	RHOA-IT1	0.07	0.04	lasso	3	0.04	4.4e-03	-4.3	-5.4	6.0e-08	-0.62	0.18	0.38	FALSE
22	GTEx	Heart Left Ventricle	AMT	0.07	0.02	lasso	7	0.02	4.6e-02	6.4	7.0	2.9e-12	0.82	0.06	0.73	TRUE
23	GTEx	Heart Left Ventricle	NICN1-AS1	0.09	0.00	enet	8	0.01	1.0e-01	6.8	6.7	2.2e-11	0.83	0.04	0.78	FALSE
24	GTEx	Lung	TCTA	0.09	0.01	enet	10	0.03	3.3e-03	6.4	6.2	5.4e-10	0.69	0.03	0.58	FALSE
25	GTEx	Nerve Tibial	KLHDC8B	0.05	0.03	lasso	13	0.02	7.1e-03	-4.5	-5.2	1.7e-07	-0.55	0.42	0.19	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	NICN1	0.07	0.09	lasso	6	0.10	4.2e-06	-5.0	5.3	9.4e-08	0.43	0.90	0.03	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	NICN1-AS1	0.06	0.11	lasso	3	0.10	4.3e-06	-5.1	5.3	1.1e-07	0.42	0.92	0.02	FALSE
28	GTEx	Skin Sun Exposed Lower leg	GPX1	0.04	0.05	lasso	3	0.04	2.9e-04	-5.1	-5.7	1.5e-08	-0.50	0.61	0.09	FALSE
29	GTEx	Skin Sun Exposed Lower leg	NICN1-AS1	0.09	0.08	lasso	7	0.06	4.6e-06	-5.0	5.2	2.0e-07	0.43	1.00	0.00	FALSE
30	GTEx	Stomach	GPX1	0.11	0.15	lasso	3	0.14	2.4e-07	-5.1	-5.3	1.4e-07	-0.45	0.96	0.01	FALSE
31	GTEx	Testis	AMT	0.19	0.14	enet	25	0.20	3.7e-09	-4.8	5.5	3.8e-08	0.50	1.00	0.00	FALSE
32	GTEx	Testis	TRAIP	0.14	0.08	enet	22	0.08	1.9e-04	6.8	6.8	8.5e-12	0.86	0.01	0.96	FALSE
33	GTEx	Thyroid	TCTA	0.04	0.02	lasso	4	0.01	2.4e-02	-4.7	6.1	8.1e-10	0.59	0.21	0.63	FALSE
34	GTEx	Thyroid	RHOA-IT1	0.05	0.05	lasso	5	0.04	5.2e-04	6.4	-6.3	2.3e-10	-0.76	0.11	0.83	FALSE
35	GTEx	Uterus	NCKIPSD	0.13	0.10	lasso	4	0.22	2.6e-05	3.7	5.7	1.6e-08	0.53	0.09	0.28	FALSE
36	GTEx	Whole Blood	AMT	0.07	0.08	enet	37	0.09	1.1e-08	-5.1	6.1	9.2e-10	0.60	0.98	0.02	FALSE
37	GTEx	Whole Blood	GPX1	0.05	0.06	enet	15	0.05	1.5e-05	-5.0	-5.3	1.2e-07	-0.46	0.99	0.00	FALSE
38	NTR	Blood	GMPPB	0.01	0.00	bslmm	311	0.00	9.6e-03	-5.0	-5.3	1.4e-07	-0.59	0.11	0.15	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	FAM212A	0.07	0.02	bslmm	286	0.03	5.0e-05	6.8	-6.7	2.3e-11	-0.82	0.02	0.98	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	KLHDC8B	0.01	0.01	blup	255	0.01	1.0e-02	-4.5	-6.1	1.1e-09	-0.65	0.09	0.35	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	BSN-AS2	0.07	0.10	lasso	6	0.09	3.5e-12	6.4	-6.4	1.3e-10	-0.83	0.11	0.89	FALSE
42	YFS	Blood	AMT	0.15	0.18	lasso	12	0.19	1.6e-60	-5.0	5.6	2.5e-08	0.49	1.00	0.00	FALSE
43	YFS	Blood	DAG1	0.01	0.00	bslmm	305	0.00	2.6e-02	-4.8	-5.3	1.1e-07	-0.69	0.02	0.24	FALSE
44	YFS	Blood	NICN1	0.15	0.20	blup	283	0.22	3.5e-70	-5.0	-5.4	6.9e-08	-0.49	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	DALRD3	0.03	0.02	lasso	2	0.02	7.3e-06	-4.5	5.3	9.8e-08	0.60	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	RBM6	0.03	0.04	blup	79	0.05	9.5e-10	-4.2	-5.1	2.6e-07	-0.62	0.11	0.84	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	USP4	0.06	0.04	lasso	5	0.05	5.3e-04	-4.9	-5.2	2.0e-07	-0.48	0.15	0.33	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC36	0.11	0.12	enet	8	0.11	8.2e-13	-4.8	5.1	2.9e-07	0.52	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GMPPB	0.09	0.05	enet	7	0.04	1.5e-03	-4.8	-5.1	3.0e-07	-0.69	0.01	0.51	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1R	0.08	0.07	enet	10	0.09	2.6e-10	4.3	6.0	2.0e-09	0.77	0.23	0.77	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	AMT	0.02	0.00	blup	25	0.01	5.4e-02	-5.0	6.1	1.4e-09	0.57	0.02	0.33	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC36	0.06	0.05	lasso	5	0.05	3.4e-06	-5.3	5.2	2.0e-07	0.56	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CAMKV	0.07	0.05	enet	9	0.06	2.3e-03	3.7	5.8	5.7e-09	0.87	0.01	0.74	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RBM6	0.16	0.12	blup	79	0.09	4.4e-04	-4.2	-5.5	3.3e-08	-0.64	0.09	0.83	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	TCTA	0.04	0.04	blup	24	0.03	3.6e-04	6.4	6.6	3.4e-11	0.74	0.01	0.97	FALSE