TWAS hub - DAG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.0647	0.0317	0.00071	0.019	NA	0.019	NA	0.003	0.033	NA	0.032	NA	0.21
2	YFS	Blood	0.0107	0.0089	0.03300	-0.001	0.001	0.001	0.003	-0.001	0.810	0.15	0.160	0.026	0.69

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Frequency of tiredness / lethargy in last 2 weeks	15.7	25.5	28.8	-5.4	4.7
Age at last live birth	14.8	21.5	42.9	6.5	-0.4
Age when periods started (menarche)	14.3	34.2	52.6	-7.2	4.0
Impedance of arm (left)	14.3	66.0	116.6	10.8	-3.9
Qualifications: College or University degree	14.3	45.2	82.6	9.1	2.8
Ever depressed for a whole week	13.9	17.1	20.2	-4.5	3.7
Age at First Birth	13.4	19.5	38.6	6.2	-0.6
Qualifications: A levels/AS levels or equivalent	13.3	29.4	48.4	7.0	3.2
Miserableness	13.1	22.8	42.9	-6.6	1.6
Impedance of arm (right)	13.0	60.5	108.2	10.4	-3.6
Ever unenthusiastic/disinterested for a whole week	12.7	15.6	19.7	-4.4	3.4
Intelligence (Savage-Jansen 2018)	12.6	38.6	57.3	7.6	4.5
Age at first live birth	12.2	21.6	42.8	6.5	-0.6
Impedance of whole body	11.9	60.6	110.2	10.5	-3.3
Pulse rate, automated reading	11.8	38.3	58.7	4.2	-7.7
Irritable Bowel Disease (IBD)	11.1	26.4	31.6	4.6	5.6
Ulcerative Colitis (UC)	10.8	20.3	29.7	5.5	3.3
Relative age of first facial hair	10.6	21.8	25.7	-5.1	4.2
Pulse rate	10.2	17.2	17.4	4.2	-4.1
Number of operations (self-reported)	10.2	15.1	24.3	-4.9	2.4
Irritability	10.2	17.3	20.9	-3.7	4.6
Chest pain or discomfort	10.0	14.4	24.0	-4.9	2.2
Overall health rating	9.7	20.7	39.8	-6.3	1.3
Smoking Status	9.5	22.7	42.1	-6.5	1.8
Ulcerative Colitis	9.4	13.6	18.1	4.3	3.0
Medication: Paracetamol	9.4	14.6	25.1	-5.0	2.0
Ever highly irritable/argumentative for 2 days	9.0	10.7	17.6	-4.2	2.0
Frequency of tenseness / restlessness in last 2 weeks	8.8	13.6	21.0	-4.6	2.5
Qualifications: None of the above	8.8	18.9	37.8	-6.2	-0.3
Taking other prescription medications	8.7	13.4	26.8	-5.2	0.1
Exposure to tobacco smoke at home	8.7	9.7	17.0	-4.1	1.6
Medication: Paracetamol	8.5	14.1	23.2	-4.8	2.2
Depressed Affect (Nagel 2018)	8.4	17.6	33.4	-5.8	1.3
Body mass index (BMI)	8.4	35.7	64.0	-8.0	-2.7
Pain all over the body in last month	8.3	8.9	15.4	-3.9	1.6
Relative age voice broke	8.1	12.4	12.5	-3.5	3.5
Pain experienced in last month	8.1	13.5	26.5	5.2	-0.6
Neck or shoulder pain in last month	7.9	11.3	17.3	-4.2	2.3
Major Depression (MDD)	7.8	9.5	15.0	-3.9	2.0
Verbal and Numeric Reasoning (VNR)	7.7	18.6	33.5	5.8	1.9
Heel T-Score	7.7	61.1	104.0	4.3	-10.2
Seen doctor (GP) for nerves, anxiety, tension or depression	7.7	11.8	18.3	-4.3	2.3
Number of full brothers	7.7	9.7	14.9	-3.9	2.1
Crohns Disease (2012)	7.5	12.1	21.0	1.8	4.6
Had major operations	7.5	8.8	12.6	-3.6	2.2
Average weekly beer plus cider intake	7.5	10.9	21.5	-4.6	-0.5
BMI	7.4	43.0	75.2	-8.7	-3.3
Chronotype (morning person)	7.3	16.8	27.2	5.2	-2.5
Crohns Disease (2017)	7.2	15.8	27.0	2.1	5.2
Other serious medical condition/disability diagnosed by doctor	7.2	9.4	18.4	-0.6	4.3
Heel bone mineral density (BMD) T-score, automated (right)	7.2	16.5	28.2	2.2	-5.3
Had other major operations	7.1	8.7	11.4	-3.4	2.4
Leg pain on walking	7.1	8.9	17.7	-4.2	0.4
Arm fat-free mass (left)	7.1	35.8	68.6	-8.3	1.7
Leg fat mass (left)	6.9	27.1	44.4	-6.7	-3.1
Medication: Co-codamol	6.8	7.9	15.6	-4.0	-0.5
Wheeze or whistling in the chest in last year	6.8	12.1	23.7	-4.9	-0.6
Leg fat mass (right)	6.7	26.1	43.3	-6.6	-3.0
Arm predicted mass (left)	6.7	34.2	65.4	-8.1	1.7
Knee pain experienced in last month	6.6	10.2	16.9	-4.1	1.9
Fed-up feelings	6.5	11.9	23.3	-4.8	-0.7
Mood swings	6.4	11.6	22.3	-4.7	1.0
Number of treatments/medications taken	6.3	11.3	22.2	-4.7	0.6
Past tobacco smoking	6.3	11.5	16.2	4.0	-2.6
Ever smoked	6.3	11.0	16.8	-4.1	2.3
Arm fat mass (right)	6.2	25.4	37.5	-6.1	-3.6
Arm predicted mass (right)	6.2	31.7	61.0	-7.8	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.2	13.2	21.6	4.7	-2.2
Fluid intelligence score	6.1	12.7	21.7	4.7	1.9
Impedance of leg (left)	6.0	29.1	56.7	7.5	-1.2
Serious illness, injury or assault of a close relative in last 2 years	6.0	6.9	7.9	-2.8	2.4
Qualifications: O levels/GCSEs or equivalent	6.0	9.6	17.2	4.1	1.4
Arm fat-free mass (right)	6.0	30.6	58.7	-7.7	1.6
Arm fat mass (left)	6.0	24.7	35.9	-6.0	-3.7
Financial situation satisfaction	6.0	7.4	13.5	-3.7	1.2
Number of full sisters	5.9	7.1	7.9	-2.5	2.8
Exposure to tobacco smoke outside home	5.8	7.7	15.5	-3.9	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	5.7	7.4	8.6	-2.9	2.5
Whole body fat mass	5.6	23.2	30.7	-5.5	-4.0
Impedance of leg (right)	5.5	26.5	51.7	7.2	-1.1
Trunk fat-free mass	5.5	31.7	54.4	-7.4	3.0
Pulse wave reflection index	5.5	6.7	8.7	-3.0	2.2
Arm fat percentage (left)	5.5	21.8	27.7	-4.0	-5.3
Leg fat percentage (left)	5.5	20.0	28.1	-5.3	-3.5
Trunk predicted mass	5.4	30.6	52.4	-7.2	3.0
Leg fat percentage (right)	5.4	19.7	28.6	-5.3	-3.3
Medication for pain relief, constipation, heartburn	5.4	9.2	11.7	3.4	-2.6
Number of self-reported non-cancer illnesses	5.4	9.3	12.9	-3.6	2.4
Weight	5.3	26.3	49.7	-7.0	-1.7
Arm fat percentage (right)	5.3	20.9	23.0	-4.3	-4.8
Mouth/teeth dental problems: Dentures	5.3	9.0	17.6	-4.2	-0.7
Mother’s age at death	5.3	6.7	10.3	3.2	-1.7
Prostate Cancer	5.2	7.3	13.1	-3.6	1.2
Heel bone mineral density (BMD) T-score, automated (left)	5.2	11.7	20.4	1.7	-4.5
Maternal smoking around birth	5.1	7.4	14.7	-3.8	0.2
Body fat percentage	5.0	19.7	27.8	-3.4	-5.3
Whole body water mass	5.0	28.5	54.3	-7.4	1.7
Basal metabolic rate	5.0	27.5	54.3	-7.4	0.8
Current tobacco smoking	4.9	7.9	15.4	-3.9	-0.7
Whole body fat-free mass	4.9	28.0	53.1	-7.3	1.7
Loneliness, isolation	4.8	6.6	12.6	-3.5	0.7
Trunk fat percentage	4.7	18.9	32.9	-2.2	-5.7
Neuroticism	4.5	10.8	18.0	-4.2	1.9
Chronic bronchitis/emphysema (father)	4.4	5.1	9.3	-3.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.4	5.2	8.1	-2.9	1.5
Guilty feelings	4.4	6.6	13.0	-3.6	0.5
Bipolar Disorder (2011)	4.3	4.2	7.1	-1.1	2.7
Respiratory disease	4.3	9.6	15.0	-3.9	2.0
Qualifications: CSEs or equivalent	4.3	5.7	11.4	-3.4	-0.1
Trunk fat mass	4.3	18.3	19.4	-4.2	-4.4
Neuroticism score	4.3	8.9	15.2	-3.9	1.6
Bipolar Disorder (2018)	4.2	6.6	6.7	-2.6	2.6
Average weekly spirits intake	4.2	5.3	9.2	-1.2	-3.0
Long-standing illness, disability or infirmity	4.2	6.4	8.2	-2.2	2.9
Smoking status: Current	4.2	6.7	12.1	-3.5	-1.1
Alcohol drinker status: Never	4.2	5.0	8.1	2.9	-1.4
Pack years adult smoking proportion	4.1	6.3	11.5	-3.4	1.0
Health satisfaction	4.1	5.4	9.7	-3.1	1.0
Family relationship satisfaction	4.1	5.1	7.1	-2.7	1.8
Smoking status: Previous	4.1	6.1	7.8	-2.8	2.1
Father’s age at death	4.0	5.3	9.2	3.0	1.2
Neuroticism (Nagel 2018)	3.9	9.2	13.5	-3.7	2.2
Leg predicted mass (left)	3.9	20.6	41.0	-6.4	-0.4
Hip circumference	3.9	16.6	32.3	-5.7	-1.0
Leg fat-free mass (left)	3.8	20.2	40.2	-6.3	-0.5
Chronic bronchitis/emphysema (mother)	3.8	4.4	7.9	-2.8	0.9
Lupus	3.7	5.7	7.0	-2.6	2.1
Pack years of smoking	3.7	5.4	8.9	-3.0	1.4
Alcohol intake versus 10 years previously	3.6	5.4	5.7	-2.3	-2.4
Forced expiratory volume in 1-second (FEV1)	3.6	12.0	23.8	4.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.5	23.0	4.8	0.1
Leg fat-free mass (right)	3.5	18.6	37.2	-6.1	-0.1
Osteoarthritis (self-reported)	3.5	4.5	9.1	-3.0	0.1
Shortness of breath walking on level ground	3.4	4.0	6.5	-2.6	1.2
Leg predicted mass (right)	3.4	18.2	36.4	-6.0	-0.1
Pain type(s) experienced in last month: Hip pain	3.4	4.3	8.0	-2.8	0.8
Schizophrenia vs Biploar Disorder	3.3	4.3	6.6	2.6	-1.4
Medication: Ramipril	3.3	4.2	4.9	-2.2	1.9
Osteoporosis (self-reported)	3.3	4.1	5.0	-2.2	1.8
Blood White Count	3.1	23.0	41.9	-6.5	-2.0
Illnesses of siblings: Diabetes	3.1	3.9	6.8	-2.6	1.0
Ever taken oral contraceptive pill	3.1	3.4	5.5	-2.4	1.1
Waist circumference	3.0	11.0	19.5	-4.4	-1.6
Happiness	3.0	3.6	6.7	-0.8	2.6
Qualifications: nursing, teaching	3.0	4.7	5.3	2.3	2.0
Tense / ‘highly strung’	2.9	4.7	6.0	-2.5	1.9
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.4	6.4	-0.7	-2.5
Bipolar Disorder or Schizophrenia	2.8	6.9	9.5	-2.1	3.1
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	6.4	-2.5	-0.2
Alcohol usually taken with meals	2.8	4.5	9.0	3.0	-0.1
Hearing difficulty/problems with background noise	2.8	4.5	5.1	-2.3	2.0
Fractured/broken bones in last 5 years	2.8	3.6	5.6	-1.3	2.4
Illnesses of siblings	2.6	3.7	5.0	1.6	-2.2
Medication: Ibuprofen	2.6	3.1	4.8	-2.2	1.1
Medication: Omeprazole	2.6	3.1	6.0	-2.5	0.3
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.9	-2.4	0.3
Coronary Artery Disease (CAD)	2.5	3.0	4.5	-2.1	-1.2
HbA1C	2.5	2.8	3.3	1.8	-1.5
Depression (self-reported)	2.5	3.0	3.3	-1.8	1.6
Prospective memory result	2.5	3.1	4.5	-1.3	-2.1
Medication: Seretide 50 evohaler	2.5	2.8	4.0	-2.0	-1.3
Neuroticism (2016)	2.4	3.5	7.0	-2.6	0.3
Sensitivity / hurt feelings	2.4	4.2	8.0	-0.6	2.8
Systolic blood pressure, automated reading	2.4	6.9	12.4	-3.5	1.2
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	6.2	0.1	2.5
Average weekly red wine intake	2.4	3.5	4.3	2.1	-1.6
Age started oral contraceptive pill	2.4	3.0	5.2	2.3	1.0
Commuting to job workplace: Cycle	2.4	3.0	4.6	2.1	-1.1
Alcohol drinker status: Previous	2.4	2.7	4.7	-2.2	0.9
Lung FVC	2.3	11.6	23.0	4.8	-0.5
Stomach or abdominal pain in last month	2.3	2.9	4.1	-2.0	1.3
Lung cancer (father)	2.3	2.7	4.4	-2.1	-1.0
Hypertension (Self-reported)	2.3	6.3	10.6	-1.4	3.2
Hair/balding pattern: Pattern 3	2.2	3.3	5.2	1.2	-2.3
Forced vital capacity (FVC), Best measure	2.2	8.0	15.9	4.0	0.4
Number of children fathered	2.2	2.4	4.6	-2.1	-0.5
Commuting to job workplace: Walk	2.2	2.4	4.7	2.2	0.0
Lung FEV1/FVC ratio	2.1	10.5	15.8	4.0	-2.3
High blood pressure	2.1	5.8	8.8	-1.7	3.0
Noisy workplace	2.1	2.6	4.9	-2.2	0.6
Hypothyroidism/myxoedema (self-reported)	2.1	4.1	6.1	-1.5	2.5
Frequency of depressed mood in last 2 weeks	2.0	2.8	4.8	-2.2	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	5.1	-2.3	-0.4
Forced vital capacity (FVC)	2.0	7.7	15.2	3.9	0.6
Mouth/teeth dental problems	2.0	3.0	4.9	2.2	-1.1
Emphysema/chronic bronchitis	2.0	2.3	2.6	-1.6	1.4
Back pain experienced in last month	2.0	2.9	5.9	-2.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	4.4	-2.1	0.7
Triglycerides	1.9	3.2	3.4	1.8	-1.7
Blood Red Count	1.9	18.5	20.9	4.0	-4.6
Ever had hysterectomy (womb removed)	1.9	2.2	3.9	-2.0	-0.7
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	2.5	-1.6	-1.2
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	2.3	-1.5	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.0	-2.0	0.9
Hypothyroidism (self reported)	1.8	4.2	5.7	-1.6	2.4
Supplements: Zinc	1.8	1.9	2.9	-1.0	1.7
Time employed in main current job	1.8	2.1	3.7	1.9	-0.7
Falls in the last year	1.8	2.5	2.9	-1.7	1.4
Comparative body size at age 10	1.8	5.0	9.2	-3.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.7	1.9	-0.7
Ever had bowel cancer screening	1.8	2.2	3.8	0.7	2.0
High cholesterol (Self-reported)	1.8	3.1	3.7	1.9	-1.6
Risk taking	1.8	2.6	5.2	-2.3	0.1
Breast Cancer	1.7	4.1	8.2	2.9	-0.1
Ever used hormone-replacement therapy (HRT)	1.7	2.2	3.3	-1.8	1.0
Severe depression (siblings)	1.7	1.9	3.6	-0.6	1.9
Friendships satisfaction	1.7	2.1	4.3	-0.1	2.1
Commuting to job workplace: Public transport	1.7	2.1	3.1	1.8	-1.0
Vascular/heart problems diagnosed by doctor	1.7	4.6	5.5	1.9	-2.4
Depression (Nagel 2018)	1.6	2.5	3.6	-1.9	1.1
Vitamin and mineral supplements	1.6	2.2	3.8	0.7	-2.0
Hair/balding pattern: Pattern 2	1.6	2.0	2.1	-1.4	1.4
Number of live births	1.6	2.3	3.3	-1.8	-1.1
Asthma	1.6	3.2	5.8	-2.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.8	1.9	0.2
Asthma (self-reported)	1.6	3.2	5.8	-2.4	0.7
Allergy	1.5	3.6	4.5	2.1	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.5	-1.9	-0.4
Fasting Glucose	1.4	1.6	3.2	0.3	-1.8
Waist Hip Ratio (WHR)	1.4	6.5	12.9	3.6	-0.2
Loud music exposure frequency	1.4	1.5	2.9	0.4	1.7
Average weekly fortified wine intake	1.3	1.6	3.1	-1.8	0.3
Medication: Levothyroxine sodium	1.3	2.3	2.3	-1.5	1.5
High blood pressure (mother)	1.3	1.8	2.5	1.1	1.6
Supplements: Calcium	1.3	1.4	2.4	-0.6	1.5
Reaction Time	1.2	2.4	4.6	0.3	2.2
Medication for hormone replacement therapy	1.2	1.3	2.6	-1.6	-0.2
Medication: Blood pressure	1.2	2.4	4.7	0.3	2.2
Illnesses of father: High blood pressure	1.2	1.5	1.5	1.2	1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	1.9	-1.1	1.4
Body Mass Index (BMI) (2010)	1.1	1.5	2.9	-1.7	-0.2
Rheumatoid Arthritis	1.1	1.6	2.7	-0.7	1.6
Schizophrenia (2014)	1.1	2.5	4.5	-0.7	2.1
Multivitamins +/- minerals	1.1	1.3	1.6	-1.0	1.3
Financial difficulties in last 2 years	1.1	1.5	3.0	-1.7	0.1
Heart attack	1.1	1.5	2.7	-1.6	-0.5
Length of working week for main job	1.1	1.2	1.6	1.2	-0.9
Peak expiratory flow (PEF)	1.1	2.6	3.7	1.9	1.3
Glaucoma (self-reported)	1.1	1.3	2.0	1.4	0.7
Mean time to correctly identify matches	1.1	2.2	4.2	0.4	2.0
Unable to work because of sickness or disability	1.1	1.4	1.9	-1.4	0.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.4	-1.6	-0.6
HDL Cholesterol	1.0	1.6	3.1	0.4	1.8
Hand grip strength (right)	1.0	2.8	3.7	-1.4	-1.9
High blood pressure (siblings)	1.0	1.5	2.3	-0.8	1.5
Migraine (self-reported)	1.0	1.2	1.9	-0.8	1.4
Medication: Allopurinol	1.0	1.3	2.0	0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	3.8	0.4	1.9
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.2	-1.1	1.5
Illnesses of father: None of the above (group 1)	1.0	1.2	1.9	0.7	-1.4
Diastolic blood pressure, automated reading	1.0	3.2	4.4	-2.1	-1.4
Schizophrenia (2018)	0.9	1.9	3.5	-0.6	1.9
Hand grip strength (left)	0.9	2.4	4.7	-0.4	-2.2
Comparative height size at age 10	0.9	4.7	8.5	2.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	1.4	0.8	-1.2
Average weekly champagne plus white wine intake	0.9	1.2	1.8	1.3	0.8
Townsend deprivation index at recruitment	0.8	1.1	2.3	-1.5	-0.1
Medication: Lansoprazole	0.8	0.9	1.6	-1.3	-0.3
Blood clot in the leg (DVT)	0.8	1.0	1.1	-1.0	1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.9	-0.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.6	-1.3	-0.3
Eye problems/disorders: Cataract	0.8	0.9	1.7	0.1	1.3
Breast cancer (self-reported)	0.8	1.0	1.8	-1.4	0.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.6	1.3	-0.6
Basal cell carcinoma (self-reported)	0.8	0.9	1.6	1.3	0.5
Medication: Atenolol	0.7	0.9	1.6	-1.3	-0.3
Had menopause	0.7	0.8	1.3	0.6	1.1
Headache pain in last month	0.7	1.3	2.0	-1.4	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-1.2	-0.6
Eye problems/disorders: None of the above	0.7	0.8	1.5	-0.2	-1.2
LDL Cholesterol	0.6	0.9	1.6	0.4	-1.3
Diabetes (father)	0.6	0.8	1.0	1.0	0.7
Breastfed as a baby	0.6	0.8	0.9	1.0	-0.8
Worry too long after embarrassment	0.6	1.0	1.3	0.8	1.1
Pulse wave peak to peak time	0.6	0.7	1.4	1.2	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.0	1.0	0.6
Mineral and other dietary supplements	0.6	0.8	1.0	0.8	-1.0
Medication: Lisinopril	0.6	0.8	1.5	0.4	1.2
Heart disease (siblings)	0.6	0.7	1.0	-1.0	0.6
Cardiovascular Disease	0.5	1.7	2.5	-0.9	1.6
Diabetes (mother)	0.5	0.6	1.1	-0.3	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-1.1	-0.2
Hair/balding pattern: Pattern 4	0.5	1.1	2.1	-0.3	-1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	0.9	0.9	0.9
Medication: Blood pressure	0.5	0.8	1.5	-1.2	0.3
Illnesses of father: Heart disease	0.5	0.7	0.9	-0.7	0.9
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.8	-0.5
Ovarian Cancer	0.4	0.6	0.7	-0.8	-0.7
Blood Eosinophil Count	0.4	3.3	5.8	-0.8	-2.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	-1.1	-0.4
Serious illness, injury or assault to yourself	0.4	0.5	0.7	-0.5	0.9
Alcohol intake frequency.	0.4	0.9	0.9	-1.0	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	0.9	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.6	0.6	0.8
Myopia	0.4	0.6	1.0	1.0	0.5
Mean Putamen Volume	0.3	0.4	0.5	0.5	0.7
Blood Platelet Count	0.3	3.8	6.9	-0.8	2.6
Height	0.3	5.3	9.2	1.2	3.0
Systolic Blood Pressure	0.3	1.4	1.8	-1.4	0.9
Tanning	0.3	3.4	6.2	-0.8	-2.5
Angina	0.3	0.4	0.5	-0.7	-0.5
Number of incorrect matches in round	0.3	0.5	0.9	-1.0	-0.0
Standing height	0.3	2.8	4.8	0.9	2.2
Gout (self-reported)	0.3	0.5	0.9	0.2	-1.0
Medication: Aspirin	0.3	0.4	0.7	0.3	0.9
Worry (Nagel 2018)	0.2	0.5	0.7	-0.5	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	-0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.6	-0.4
Nervous feelings	0.2	0.4	0.5	0.5	0.7
Medication: Simvastatin	0.2	0.4	0.4	0.5	-0.7
Worrier / anxious feelings	0.2	0.3	0.6	-0.8	0.0
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.4	-0.7
Angina (self-reported)	0.2	0.3	0.4	-0.6	-0.4
Medication: Aspirin	0.2	0.3	0.3	0.5	0.5
Wears glasses or contact lenses	0.2	0.3	0.5	-0.7	-0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.7	-0.0
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.2	0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.2	-0.4
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.6	0.0
Allergy or Eczema	0.1	0.4	0.7	-0.2	0.8
Hair Pigment	0.1	3.5	6.2	-2.5	0.9
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.5	0.1
Medication: Metformin	0.1	0.1	0.2	-0.2	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.1	0.5
Supplements: Glucosamine	0.1	0.1	0.2	-0.1	-0.5
Sitting height	0.1	1.0	1.1	0.9	-1.0
Diabetes (self-reported)	0.1	0.1	0.2	-0.5	-0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	-0.4
Illnesses of mother	0.1	0.2	0.3	-0.2	-0.5
Birth weight of first child	0.1	0.1	0.3	0.1	0.5
Medication: Amlodipine	0.1	0.1	0.2	0.4	0.2
Heart disease (mother)	0.1	0.2	0.3	-0.0	0.6
Medication for cholesterol	0.1	0.1	0.2	0.5	-0.2
Medication: Gliclazide	0.1	0.1	0.3	-0.5	-0.1
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	0.5
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.2	0.2
Birth weight	0.0	0.1	0.1	-0.3	-0.2
Suffer from ‘nerves’	0.0	0.0	0.0	-0.2	0.2
Supplements: Vitamin C	0.0	0.0	0.0	-0.1	0.1
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.3	-0.1
Hearing aid user	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

DAG1

Models

Trait associations