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chr10:102,640,116-105,282,664

Best TWAS P=3.05e-14 · Best GWAS P=1.4e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-5.29	-7.6	3.1e-14	0.83	0.08	0.90	TRUE
13	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-3.06	-5.9	4.6e-09	0.70	0.24	0.68	TRUE
37	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C10orf76	0.19	0.20	lasso	1	0.18	4.6e-07	-5.79	-5.8	7.2e-09	0.13	0.02	0.98	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-5.31	-5.4	7.7e-08	0.78	0.27	0.70	TRUE
20	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-5.29	5.3	8.7e-08	-0.90	0.22	0.77	TRUE
1	CommonMind	Brain Pre-frontal Cortex	NPM3	0.03	0.01	lasso	2	0.03	1.2e-04	-6.05	5.2	2.0e-07	-0.10	0.01	0.95	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPM3	0.04	0.02	blup	22	0.02	1.8e-03	-6.01	5.2	2.6e-07	-0.03	0.00	0.64	TRUE
5	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	4.98	7.3	3.3e-13	-0.52	0.10	0.77	FALSE
15	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-5.55	-7.0	2.0e-12	0.22	0.06	0.18	FALSE
21	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-5.51	6.7	2.4e-11	-0.83	0.08	0.91	FALSE
6	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	4.98	6.5	8.1e-11	-0.71	0.06	0.80	FALSE
4	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	-6.23	6.4	1.3e-10	-0.72	0.04	0.70	FALSE
7	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	6.24	6.4	1.7e-10	-0.51	0.04	0.73	FALSE
2	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	3.64	6.2	7.1e-10	-0.43	0.04	0.88	FALSE
14	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-3.78	-6.1	1.2e-09	0.76	0.12	0.79	FALSE
27	The Cancer Genome Atlas	Esophageal Carcinoma	SFXN2	0.26	0.02	blup	48	0.10	4.9e-04	5.40	-6.1	1.4e-09	0.33	0.02	0.64	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	POLL	0.08	0.05	blup	299	0.06	4.4e-08	3.50	6.0	1.6e-09	-0.13	0.99	0.01	FALSE
3	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	1.14	6.0	1.8e-09	-0.31	0.05	0.33	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPM3	0.02	0.03	lasso	3	0.02	9.2e-04	-5.79	6.0	2.6e-09	-0.14	0.01	0.82	FALSE
22	GTEx	Testis	NPM3	0.13	0.15	lasso	3	0.13	2.5e-06	-5.79	5.8	7.6e-09	-0.14	0.03	0.96	FALSE
11	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-4.01	-5.7	1.1e-08	0.73	0.16	0.50	FALSE
19	GTEx	Pancreas	NPM3	0.20	0.15	lasso	4	0.07	5.4e-04	-5.79	5.7	1.1e-08	-0.13	0.04	0.92	FALSE
9	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	6.23	5.6	2.7e-08	-0.62	0.03	0.84	FALSE
12	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-5.50	5.5	3.6e-08	-0.90	0.11	0.65	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM180	0.13	0.03	blup	52	0.02	5.7e-02	0.86	5.5	4.6e-08	-0.57	0.02	0.28	FALSE
17	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	5.04	5.5	4.8e-08	-0.46	0.05	0.94	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	5.04	5.4	6.1e-08	-0.41	0.09	0.62	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	SFXN2	0.15	0.10	enet	9	0.11	2.4e-08	5.33	-5.4	6.7e-08	0.28	0.41	0.59	FALSE
23	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-3.78	5.4	7.3e-08	-0.67	0.98	0.02	FALSE
18	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	5.03	5.3	1.1e-07	-0.43	0.42	0.35	FALSE
30	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFXN2	0.20	0.08	blup	48	0.13	9.3e-07	5.40	-5.3	1.1e-07	0.20	0.13	0.82	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-5.50	-5.3	1.1e-07	0.89	0.04	0.59	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFXN2	0.12	0.09	lasso	4	0.10	4.4e-19	5.40	-5.3	1.2e-07	0.25	0.30	0.70	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-5.29	5.3	1.2e-07	-0.77	0.02	0.98	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-5.36	5.3	1.4e-07	-0.75	0.03	0.27	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-5.27	-5.3	1.4e-07	0.85	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM180	0.05	0.02	blup	52	0.04	1.5e-05	-5.56	5.2	1.7e-07	-0.74	0.02	0.95	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	5.02	-5.2	1.7e-07	0.34	0.11	0.81	FALSE