Hub : Genes

POLL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0860 0.0270 1.0e-08 0.104 0.076 0.110 0.100 0.106 1.4e-12 1.7e-09 2.6e-13 3.7e-12 8.2e-13
2 GTEx Cells Transformed fibroblasts 0.0430 0.0230 8.4e-03 0.001 NA -0.003 NA -0.003 2.7e-01 NA 7.1e-01 NA 6.7e-01
3 GTEx Small Intestine Terminal Ileum 0.3230 0.1100 8.1e-03 0.075 NA 0.100 NA 0.111 9.7e-03 NA 3.1e-03 NA 1.9e-03
4 GTEx Testis 0.1050 0.0460 3.0e-03 0.124 NA 0.082 NA 0.079 3.8e-06 NA 1.8e-04 NA 2.1e-04
5 ROSMAP Brain Pre-frontal Cortex 0.0783 0.0257 6.1e-08 0.050 0.059 0.046 0.058 0.048 4.8e-07 4.4e-08 1.3e-06 6.3e-08 7.7e-07
6 TCGA Brain Lower Grade Glioma 0.0167 0.0108 5.4e-03 0.018 0.013 0.014 NA 0.013 3.0e-03 1.1e-02 8.5e-03 NA 1.1e-02
7 TCGA Lung Squamous Cell Carcinoma 0.0413 0.0227 3.4e-06 0.037 0.052 0.045 NA 0.042 4.4e-05 1.2e-06 6.9e-06 NA 1.4e-05
8 TCGA Pancreatic Adenocarcinoma 0.0590 0.0390 3.2e-03 0.016 0.043 0.004 NA 0.006 6.8e-02 6.5e-03 2.0e-01 NA 1.8e-01
9 TCGA Thyroid Carcinoma 0.0230 0.0150 2.1e-03 0.016 0.027 0.025 NA 0.025 9.2e-03 1.1e-03 1.5e-03 NA 1.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.6 0.9 2.3 1.5 1.1 0.7 -1.2 0.7 0.4 0.8 1.0 0.5
Bipolar Disorder or Schizophrenia 0.4 1.1 5.6 2.4 1.1 -0.1 -1.4 -0.2 0.1 0.2 0.9 -0.2
Depressed Affect (Nagel 2018) 0.3 0.5 1.8 -0.5 -0.5 0.4 0.9 -0.9 -1.3 -0.4 0.4 -0.7
Depression (Nagel 2018) 0.4 0.6 1.7 -0.8 -0.5 -1.0 1.3 -0.8 -1.0 -0.4 -0.0 -0.5
Intelligence (Savage-Jansen 2018) 4.0 12.3 24.3 -3.5 -3.0 -0.9 3.4 -4.9 -3.8 -3.5 -3.5 -3.7
Neuroticism (Nagel 2018) 0.6 1.4 5.4 0.6 1.6 0.2 -0.0 -0.1 -0.5 1.5 2.3 1.1
Schizophrenia (2018) 0.3 0.7 3.3 1.8 0.6 -0.7 -0.8 -0.8 -0.2 -0.3 0.3 -0.6
Schizophrenia vs Biploar Disorder 0.4 0.5 1.2 1.1 0.8 -0.8 -0.8 0.3 0.8 0.2 0.5 0.2
Worry (Nagel 2018) 2.0 4.1 11.0 1.4 2.9 -0.1 -0.8 1.1 0.6 2.7 3.3 2.5
Alzheimer’s Disease (in mother) 0.1 0.1 0.6 0.0 0.1 -0.8 0.0 0.3 -0.3 -0.0 0.2 -0.1
Alzheimer’s Disease (in father) 1.5 1.6 3.3 1.3 1.3 -1.8 -0.7 1.4 0.7 1.3 1.2 1.3
Alzheimer’s Disease (including proxy) 0.4 0.5 1.7 1.0 0.5 -1.3 -0.6 0.7 0.4 0.5 0.6 0.4
Crohns Disease (2017) 0.3 0.6 1.7 -1.0 -0.1 -1.2 1.3 -0.3 -0.6 -0.5 -0.4 -0.4
Irritable Bowel Disease (IBD) 0.1 0.3 1.3 -1.0 0.3 -0.6 1.1 -0.1 -0.4 -0.1 -0.1 -0.1
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.6 0.5 0.1 0.7 0.1 -0.2 0.3 0.3 0.3
Major Depression (MDD) 1.7 2.1 3.1 1.7 1.8 -1.6 -1.1 0.5 1.2 1.7 1.5 1.5
Reaction Time 1.5 2.9 5.5 -1.5 -1.4 -1.7 2.2 -2.1 -2.3 -1.0 -1.2 -1.3
Verbal and Numeric Reasoning (VNR) 4.0 9.5 18.4 -2.9 -3.2 0.3 2.4 -4.3 -2.8 -3.4 -3.4 -3.4
Breast Cancer 2.5 6.0 10.8 3.1 1.9 0.2 -3.3 1.7 3.1 2.5 1.9 2.7
Ovarian Cancer 0.5 0.6 1.7 0.7 0.0 0.8 -1.0 1.2 1.3 0.2 -0.1 0.4
Prostate Cancer 0.2 0.3 1.0 0.3 0.8 0.3 -0.5 -0.2 -0.1 0.5 1.0 0.5
Age at First Birth 0.7 1.0 2.0 -0.6 -0.8 -0.9 0.6 -1.4 -0.8 -1.3 -1.1 -1.3
Bipolar Disorder (2011) 4.1 3.9 8.3 2.9 1.9 -0.0 -2.5 1.2 1.9 2.0 2.0 2.0
Body Mass Index (BMI) (2010) 0.7 1.0 3.3 0.3 -1.3 -1.0 -0.3 -0.2 0.1 -1.4 -1.8 -1.0
Coronary Artery Disease (CAD) 1.2 1.5 2.8 -0.7 -1.6 -0.5 0.9 -0.6 -0.9 -1.6 -1.6 -1.7
Crohns Disease (2012) 0.2 0.3 1.1 0.3 1.0 -1.0 -0.1 0.3 0.3 0.3 0.7 0.2
Mean Putamen Volume 2.0 2.3 3.5 -1.6 -1.7 1.1 1.0 -1.7 -1.0 -1.7 -1.9 -1.7
Fasting Glucose 0.9 1.0 3.1 1.0 -0.1 1.8 -1.4 0.8 1.3 0.3 -0.0 0.7
HbA1C 0.5 0.6 2.7 0.8 0.0 -0.2 -0.6 1.6 0.9 0.5 -0.0 0.7
HDL Cholesterol 0.3 0.5 1.3 -1.1 -0.8 0.8 0.8 -0.1 -0.6 -0.6 -0.6 -0.5
LDL Cholesterol 0.6 0.9 2.0 0.9 -0.9 1.4 -1.2 -0.7 0.5 -0.8 -0.9 -0.8
Lupus 1.3 2.0 3.6 -1.6 -1.5 0.5 1.1 -1.9 -1.5 -1.4 -1.3 -1.3
Neuroticism (2016) 0.5 0.7 3.2 0.1 -0.4 1.1 0.1 -1.8 -0.9 -0.6 -0.3 -0.8
Primary Biliary Cirrhosis 2.4 3.5 12.2 -1.7 -2.4 3.5 0.8 -0.6 -0.9 -1.7 -2.0 -1.4
Rheumatoid Arthritis 0.8 1.2 2.8 -1.7 -0.8 1.1 1.4 -0.2 -1.4 -0.9 -0.7 -0.9
Schizophrenia (2014) 0.3 0.6 2.7 1.6 0.3 0.0 -0.7 -0.9 -0.2 -0.5 0.1 -0.9
Triglycerides 0.7 1.1 2.2 1.0 0.3 -0.2 -0.8 1.3 1.5 1.2 0.5 1.5
Type 2 Diabetes (T2D) (2012) 0.4 0.5 2.1 0.9 0.2 1.4 -0.9 0.2 0.6 -0.1 -0.3 -0.1
Ulcerative Colitis 0.3 0.5 1.7 -0.1 1.1 -1.3 0.3 -0.6 -0.1 0.4 0.7 0.3
Blood Eosinophil Count 0.0 0.3 1.0 -0.0 -0.2 1.0 -0.2 -0.1 -0.1 -0.9 -0.1 -0.8
Blood Platelet Count 0.4 5.1 21.6 -1.3 -2.5 4.7 0.5 -2.2 -0.8 -1.9 -1.8 -1.9
Blood Red Count 0.3 3.2 8.6 -2.2 -0.5 -1.2 2.9 -1.0 -2.9 -1.4 -0.3 -1.7
Blood White Count 0.5 3.4 7.6 1.5 2.4 1.4 -1.6 1.9 1.2 1.9 2.8 1.7
Heel T-Score 0.4 3.4 13.0 -1.5 -1.3 3.6 0.6 -1.2 -0.8 -2.2 -1.4 -2.1
BMI 1.7 9.8 18.7 -2.5 -4.2 0.4 1.9 -2.0 -1.9 -4.3 -4.3 -4.0
Height 1.8 35.2 57.3 5.6 5.8 1.6 -6.5 6.0 7.6 6.3 5.7 6.5
Waist Hip Ratio (WHR) 0.5 2.3 4.9 1.2 1.9 0.1 -0.9 2.2 1.1 1.6 2.0 1.6
Systolic Blood Pressure 5.2 25.9 38.8 5.8 6.2 -1.1 -4.7 4.1 4.7 5.8 5.8 5.6
Smoking Status 2.2 5.1 13.2 0.9 3.6 -1.8 -0.3 2.0 1.2 2.6 3.6 2.0
Allergy or Eczema 3.2 8.3 11.0 -2.6 -3.3 0.7 2.4 -3.3 -3.2 -3.2 -3.1 -3.1
Cardiovascular Disease 0.2 0.8 1.8 0.0 1.2 -1.3 0.5 -0.1 -0.5 1.0 1.3 0.6
Hypothyroidism (self reported) 2.3 5.2 7.8 1.5 2.8 -1.6 -1.4 2.8 1.9 2.7 2.7 2.5
Respiratory disease 0.6 1.4 2.0 -1.1 -1.4 0.5 1.2 -0.9 -1.1 -1.3 -1.4 -1.3
Type 2 Diabetes (T2D) (2018) 1.8 3.3 7.2 -0.5 -2.1 1.2 0.1 -2.1 -1.2 -2.7 -2.2 -2.4
Lung FEV1/FVC ratio 0.2 0.8 4.8 -0.8 -0.4 1.0 0.1 2.2 0.6 0.2 0.1 0.4
Lung FVC 0.0 0.2 1.1 -0.4 -1.1 0.3 0.4 0.2 0.2 0.1 -0.3 0.1
Neuroticism 1.1 2.5 9.1 1.0 2.4 0.7 -0.7 0.2 -0.3 1.9 3.0 1.5
Chronotype (morning person) 0.2 0.5 1.7 -1.3 0.1 -1.0 0.7 0.5 0.8 0.1 -0.1 0.5
Hair Pigment 0.0 0.4 1.1 -1.0 -0.0 0.6 0.5 1.1 0.6 0.4 0.7 0.4
Tanning 0.1 0.9 1.6 -0.6 -0.9 -0.2 0.7 -0.9 -1.1 -1.2 -1.1 -1.3
Hand grip strength (left) 6.3 16.5 36.4 3.5 3.8 0.7 -3.5 6.0 4.7 4.0 4.0 4.2
Number of treatments/medications taken 0.7 1.2 2.9 0.8 1.5 -1.7 -0.5 0.1 0.5 1.3 1.3 1.1
Average weekly spirits intake 0.7 0.8 2.8 0.9 0.4 -0.7 -0.9 1.7 1.5 0.2 -0.3 0.4
Sensitivity / hurt feelings 2.5 4.2 9.0 2.1 2.8 0.1 -1.6 1.5 1.1 2.4 3.0 2.2
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.3 0.1 1.0 -0.7 0.0 0.5 0.0 0.9 1.1 0.8
Hearing difficulty/problems: Yes 0.7 1.1 2.7 -1.2 -0.0 -1.6 1.6 -0.9 -1.5 0.4 0.2 0.1
Relative age of first facial hair 1.9 3.8 6.1 -2.4 -2.5 1.6 1.9 -1.3 -1.5 -2.1 -1.9 -2.0
Other serious medical condition/disability diagnosed by doctor 1.6 2.0 3.2 -1.4 -1.6 -0.1 1.4 -1.2 -1.8 -1.5 -1.6 -1.6
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.3 0.6 1.0 0.2 -0.3 1.2 0.8 0.8 0.5 0.7
Ever had hysterectomy (womb removed) 0.7 0.8 2.2 0.9 1.2 -0.4 -0.5 0.7 0.3 1.1 1.5 0.9
Systolic blood pressure, automated reading 1.4 4.2 6.6 2.6 2.4 -0.2 -2.1 1.6 1.9 2.2 2.2 2.2
Eye problems/disorders: Diabetes related eye disease 5.3 5.9 7.8 -2.8 -2.7 -0.2 2.6 -2.1 -2.3 -2.7 -2.7 -2.5
Angina 1.0 1.4 3.6 0.6 1.5 -1.9 -0.3 1.1 1.0 1.2 1.1 1.1
Medication for hormone replacement therapy 0.7 0.8 3.5 -0.1 -0.0 1.6 -0.0 1.9 0.8 0.5 -0.3 0.5
Vitamin and mineral supplements 0.5 0.7 1.8 1.4 0.1 -0.1 -1.1 1.1 1.2 0.3 -0.2 0.6
Supplements: Zinc 0.1 0.1 0.4 -0.3 0.2 -0.0 0.3 0.1 -0.6 0.6 0.5 0.3
Medication: Co-codamol 0.1 0.2 0.8 0.9 0.1 -0.0 -0.8 0.1 -0.1 0.2 0.2 0.0
Medication: Metformin 4.2 5.9 10.9 -1.6 -2.2 -0.7 1.5 -3.0 -2.6 -3.3 -2.7 -3.1
Diabetes (father) 0.3 0.3 2.0 -0.4 0.5 -1.4 0.7 0.2 -0.3 0.2 0.1 0.0
Diabetes (mother) 0.7 0.9 1.5 0.9 1.1 0.9 -1.2 1.0 0.4 0.9 0.9 1.0
Severe depression (siblings) 0.5 0.5 1.9 0.1 0.5 -1.4 0.3 -1.3 -0.6 0.2 0.4 -0.1
Pack years adult smoking proportion 0.1 0.2 1.2 0.2 0.2 -0.5 -0.0 1.1 0.1 -0.3 -0.4 -0.3
Impedance of leg (right) 0.4 1.8 6.1 0.8 1.1 2.5 -1.4 0.7 0.9 1.2 1.5 1.3
Leg fat-free mass (left) 0.2 1.0 4.4 0.9 0.1 -0.3 -1.2 1.6 2.1 0.2 -0.1 0.4
Trunk fat percentage 3.1 12.5 20.4 -3.4 -4.1 1.5 2.6 -3.2 -3.1 -4.5 -3.9 -4.5
Hand grip strength (right) 4.5 12.2 24.8 3.3 3.0 0.6 -3.4 5.0 4.5 3.3 2.9 3.6
Townsend deprivation index at recruitment 3.2 4.6 6.7 2.4 2.4 0.6 -2.6 2.2 2.5 2.0 2.1 1.9
Current tobacco smoking 1.9 3.1 6.7 0.9 2.6 -2.0 -0.6 2.3 1.4 1.6 2.1 1.3
Average weekly fortified wine intake 3.0 3.6 7.2 -2.7 -1.8 0.3 2.3 -1.5 -2.1 -1.8 -1.6 -1.9
Maternal smoking around birth 1.1 1.6 5.7 1.1 1.2 -2.4 -0.7 1.7 1.4 0.7 0.4 0.5
Fed-up feelings 0.7 1.3 2.9 -0.9 -1.0 1.3 0.9 -1.1 -1.7 -1.2 -0.5 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.9 -1.0 -0.6 -0.8 1.4 -0.1 -0.6 -0.4 -0.3 -0.5
Relative age voice broke 0.8 1.3 2.7 -1.4 -1.6 1.1 0.9 0.0 -0.8 -1.3 -1.2 -1.1
Taking other prescription medications 0.1 0.1 0.5 -0.2 -0.1 -0.3 0.2 -0.4 -0.7 -0.0 -0.1 -0.1
Age when periods started (menarche) 1.4 3.5 8.3 -2.9 -1.5 0.5 2.9 -0.9 -1.8 -1.8 -1.4 -1.7
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 3.6 1.6 1.3 -1.9 -0.9 1.1 0.9 1.3 1.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.2 6.7 -1.7 -2.1 1.9 1.2 -2.0 -1.8 -2.6 -2.1 -2.6
Tinnitus: Yes, but not now, but have in the past 2.8 3.0 4.1 1.5 2.0 -1.1 -1.5 1.7 2.0 2.0 1.8 1.8
Qualifications: CSEs or equivalent 0.2 0.3 2.2 0.4 0.2 -1.5 0.1 0.6 0.4 -0.0 0.0 -0.1
Serious illness, injury or assault to yourself 1.1 1.4 4.2 -0.7 -1.3 1.1 0.4 -2.1 -0.9 -1.1 -1.2 -1.1
High blood pressure 0.5 1.5 3.6 -0.2 1.6 -1.3 0.5 -0.2 -0.2 1.8 1.9 1.3
Hayfever, allergic rhinitis or eczema 3.1 6.7 9.8 -2.7 -3.0 0.4 2.7 -3.1 -3.0 -2.5 -2.5 -2.4
Multivitamins +/- minerals 0.3 0.4 1.0 -0.8 0.4 0.3 0.5 -0.8 -1.0 0.2 0.7 -0.2
Stomach or abdominal pain in last month 0.2 0.3 1.0 0.2 0.1 0.7 -0.4 1.0 0.2 0.6 0.5 0.4
Supplements: Glucosamine 0.2 0.3 0.8 -0.2 0.7 -0.8 0.4 0.9 -0.1 0.6 0.5 0.3
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.3 -0.2 -0.6 -0.4 0.4 -1.1 -0.7 -1.5 -1.3 -1.5
Medication: Atenolol 0.9 1.2 3.6 0.3 1.7 -0.7 -0.2 0.4 -0.1 1.4 1.9 1.2
Medication: Levothyroxine sodium 1.2 2.0 3.6 1.2 1.9 -1.9 -1.0 1.1 0.9 1.3 1.8 1.3
Sitting height 2.1 14.7 29.1 4.3 3.5 -1.0 -4.2 3.2 5.4 3.9 3.2 4.2
Chronic bronchitis/emphysema (father) 1.5 1.7 3.3 1.5 1.2 1.3 -1.6 1.3 1.8 1.0 0.7 1.0
High blood pressure (mother) 1.7 2.4 4.2 1.7 1.3 -0.5 -1.9 0.5 1.7 2.0 1.4 2.0
Body mass index (BMI) 2.5 10.5 18.3 -2.6 -4.2 0.5 2.3 -2.3 -2.4 -4.3 -4.2 -4.1
Impedance of leg (left) 0.4 1.8 5.8 0.5 1.2 2.4 -1.2 0.2 0.5 1.3 1.7 1.3
Leg predicted mass (left) 0.2 1.0 4.4 0.9 0.1 -0.3 -1.2 1.5 2.1 0.2 -0.1 0.4
Trunk fat mass 1.6 7.0 13.0 -2.5 -3.3 1.3 1.6 -1.9 -1.7 -3.6 -3.2 -3.5
Waist circumference 0.6 2.0 4.1 -1.2 -1.8 0.8 0.8 -0.5 -1.1 -2.0 -1.7 -2.0
Number of incorrect matches in round 2.6 4.4 7.9 1.3 2.5 -0.3 -1.2 2.6 1.9 2.6 2.2 2.8
Past tobacco smoking 0.6 1.0 2.6 -0.1 -1.5 1.5 -0.3 -0.7 0.0 -1.2 -1.6 -0.6
Alcohol usually taken with meals 0.6 1.0 2.6 -0.8 -1.1 -0.5 0.7 -1.6 -1.0 -1.1 -0.9 -1.1
Nervous feelings 1.1 2.0 5.6 1.3 2.4 -0.3 -0.8 0.1 0.0 1.7 2.2 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.1 -0.3 -0.4 -1.0 0.9 -0.9 -1.4 -0.8 -0.2 -0.8
Hearing difficulty/problems with background noise 1.2 1.9 5.1 -1.6 -1.1 0.1 1.7 -1.8 -2.2 -0.8 -0.7 -1.1
Hair/balding pattern: Pattern 2 1.1 1.5 2.5 -1.5 -1.5 -0.4 1.6 -0.9 -0.7 -1.3 -1.2 -1.3
Had menopause 1.2 1.5 2.2 -0.7 -1.2 -1.1 1.4 -0.7 -1.3 -1.4 -1.4 -1.5
Had other major operations 0.2 0.2 0.6 0.5 -0.6 -0.3 -0.4 -0.8 0.2 -0.2 -0.4 -0.3
Forced vital capacity (FVC) 1.6 6.3 14.3 2.3 1.1 1.4 -2.7 3.2 3.8 2.4 1.7 2.7
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 6.4 -1.8 -2.2 1.9 1.4 -2.1 -2.0 -2.5 -2.0 -2.5
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 3.3 1.8 1.7 0.4 -1.7 1.3 1.4 1.7 1.8 1.7
Qualifications: None of the above 2.0 4.3 11.0 2.2 1.9 -0.3 -1.9 3.3 2.3 1.8 2.0 1.8
Financial difficulties in last 2 years 0.4 0.5 1.2 -0.2 -1.1 0.5 0.5 -0.7 -0.1 -0.8 -1.0 -0.7
Mouth/teeth dental problems 1.0 1.5 4.5 1.2 -0.0 0.8 -1.3 2.1 1.8 0.7 -0.1 1.1
Heart attack 0.1 0.1 0.2 0.3 -0.1 0.3 0.1 0.4 -0.4 0.1 -0.0 0.1
Allergy 3.6 8.4 11.8 3.1 3.1 0.1 -3.3 2.6 3.4 2.9 3.0 3.0
Pain all over the body in last month 0.1 0.1 0.3 -0.4 -0.2 -0.4 0.3 -0.0 -0.2 -0.5 -0.3 -0.4
Diabetes (self-reported) 3.4 5.3 9.3 -1.6 -2.4 0.7 1.5 -2.6 -2.2 -3.0 -2.6 -3.0
Hayfever/allergic rhinitis (self-reported) 2.7 3.5 6.9 -2.6 -1.6 -0.1 2.6 -1.4 -2.1 -1.8 -1.9 -1.7
Medication: Ramipril 0.3 0.4 0.7 -0.8 -0.3 -0.7 0.7 -0.8 -0.8 -0.3 -0.5 -0.3
Medication: Simvastatin 1.4 2.0 4.2 -1.4 -0.9 0.1 1.3 -2.0 -1.7 -1.6 -1.2 -1.7
Fluid intelligence score 2.5 5.2 7.5 -2.0 -2.7 1.1 1.7 -2.7 -1.8 -2.5 -2.7 -2.6
Illnesses of siblings 0.5 0.7 1.6 -0.1 -0.8 -0.5 0.2 -1.3 -0.7 -1.2 -0.9 -1.2
Neuroticism score 0.4 0.8 3.0 0.4 1.3 -0.0 0.2 -0.1 -1.1 0.8 1.7 0.4
Weight 0.3 1.4 3.4 -0.5 -1.8 0.6 -0.0 -0.1 0.3 -1.8 -1.8 -1.6
Impedance of arm (right) 0.3 1.2 4.0 -1.4 0.2 1.1 1.0 -1.3 -2.0 -0.5 0.5 -0.8
Arm fat percentage (right) 3.2 12.6 22.1 -3.2 -4.2 0.9 2.6 -2.6 -3.3 -4.7 -4.1 -4.7
Trunk fat-free mass 1.4 7.9 17.2 2.8 2.4 -0.8 -2.9 3.6 4.2 2.6 2.0 2.9
Hip circumference 1.3 5.4 9.9 -2.0 -3.1 1.4 1.3 -1.5 -1.6 -3.1 -2.9 -3.0
Time employed in main current job 1.5 1.7 2.4 1.2 1.5 0.5 -1.0 1.4 1.5 1.4 1.3 1.5
Alcohol intake versus 10 years previously 0.2 0.3 1.1 0.1 0.1 0.2 0.2 0.4 1.0 0.6 0.3 0.7
Father’s age at death 0.6 0.9 2.7 -1.2 -0.8 0.6 1.0 -0.8 -1.7 -0.7 -0.5 -0.7
Worrier / anxious feelings 1.3 2.4 6.5 1.2 2.1 0.3 -0.9 0.3 0.6 2.1 2.5 2.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 1.4 -0.5 -0.9 0.2 0.8 0.2 -0.6 -1.0 -0.6 -1.2
Falls in the last year 0.3 0.4 1.2 -0.2 -0.6 0.2 0.3 -1.1 -0.9 -0.5 -0.6 -0.7
Hair/balding pattern: Pattern 3 0.2 0.3 1.7 -0.4 -0.4 0.2 0.2 -1.3 -0.5 -0.3 -0.3 -0.3
Number of live births 6.5 9.3 14.4 -3.1 -3.8 0.6 2.8 -2.6 -2.7 -3.5 -3.6 -3.4
Forced expiratory volume in 1-second (FEV1) 1.7 5.9 14.2 2.2 0.6 1.8 -2.7 3.5 3.8 1.9 1.2 2.3
Pulse rate 1.1 1.8 5.4 -0.4 -0.7 -0.7 0.7 -2.3 -1.5 -1.6 -1.1 -1.8
Happiness 0.5 0.7 2.7 0.0 -0.9 0.3 -0.2 -1.6 0.0 -0.8 -1.0 -0.8
Noisy workplace 1.2 1.4 2.9 -1.2 -1.4 0.1 1.2 -0.2 -0.9 -1.5 -1.7 -1.5
Qualifications: A levels/AS levels or equivalent 1.3 2.9 4.3 -2.1 -1.6 -0.7 1.7 -1.8 -2.0 -1.6 -1.9 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.8 0.4 0.3 0.4 -0.2 -0.2 0.1 0.9 0.8 0.8
Mouth/teeth dental problems: Dentures 0.2 0.4 1.2 0.1 1.0 -0.2 0.2 -1.1 -0.8 0.3 0.9 -0.1
Asthma 0.8 1.5 2.6 -1.2 -1.6 0.4 1.4 -0.6 -1.2 -1.3 -1.6 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.4 1.6 0.2 -0.9 -1.3 0.3 1.3 -0.3 -0.3 -0.0
Medication: Cholesterol lowering 0.0 0.0 0.1 -0.0 0.4 -0.3 -0.0 0.1 0.4 0.0 -0.2 -0.0
Depression (self-reported) 0.2 0.3 0.7 0.8 0.4 0.6 -0.7 -0.0 0.5 0.2 0.5 0.2
Medication: Lansoprazole 1.7 1.9 3.9 2.0 1.8 -1.1 -1.6 1.5 1.2 0.8 1.1 0.8
Prospective memory result 3.1 3.8 7.4 1.2 1.8 1.0 -1.5 1.9 1.9 2.5 2.3 2.7
Lung cancer (father) 0.7 0.8 1.9 1.2 1.4 0.4 -1.1 -0.0 0.4 0.9 1.1 0.7
Illnesses of mother 1.1 1.3 3.1 -0.5 -1.0 0.3 0.7 -1.5 -0.5 -1.7 -1.4 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 7.3 1.4 0.3 0.9 -1.8 2.5 2.7 1.0 0.6 1.4
Pulse wave Arterial Stiffness index 0.3 0.3 1.1 0.4 0.7 -1.1 -0.2 0.5 -0.3 0.5 0.4 0.6
Impedance of arm (left) 0.4 1.8 5.0 -1.8 0.0 1.2 1.3 -1.9 -2.2 -0.7 0.3 -0.9
Arm fat mass (right) 1.6 6.7 13.2 -2.0 -3.3 1.0 1.5 -1.6 -1.8 -3.6 -3.3 -3.5
Trunk predicted mass 1.4 7.8 17.1 2.7 2.4 -0.7 -2.8 3.5 4.1 2.6 2.0 2.8
Standing height 2.1 20.6 32.0 3.9 4.7 0.8 -4.6 4.7 5.7 4.9 4.7 5.1
Length of working week for main job 0.8 0.9 3.8 -0.1 -0.8 2.0 -0.6 0.3 -0.0 -1.1 -1.0 -0.8
Exposure to tobacco smoke at home 1.4 1.6 2.8 1.7 1.2 -1.5 -1.4 0.9 1.4 1.0 0.6 1.1
Breastfed as a baby 1.0 1.3 2.7 1.5 0.5 -0.1 -1.3 1.4 1.7 0.9 0.5 1.1
Tense / ‘highly strung’ 1.5 2.5 4.9 1.3 2.2 -2.0 -0.7 1.5 0.8 1.8 1.9 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 4.8 1.7 2.2 -1.0 -1.4 1.2 1.6 2.2 2.2 1.9
Hair/balding pattern: Pattern 4 4.8 11.6 16.1 2.8 3.4 1.0 -3.2 4.0 3.4 4.0 3.9 3.9
Birth weight of first child 0.1 0.2 0.9 -0.3 0.0 -0.7 0.3 -0.9 -0.1 -0.1 -0.0 -0.2
Peak expiratory flow (PEF) 2.8 6.5 11.8 2.4 1.6 1.9 -3.0 3.1 3.4 2.3 2.1 2.6
Pulse wave reflection index 0.3 0.4 1.0 -0.3 -0.1 0.4 -0.3 0.9 0.8 0.7 0.2 1.0
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.0 0.8 -0.2 -1.4 -0.5 1.1 1.1 -0.0 -0.5 0.1
Loud music exposure frequency 1.3 1.4 4.5 -0.4 -1.7 -0.4 0.6 -0.1 -0.5 -1.5 -2.1 -1.4
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 2.6 -1.5 -0.9 -0.4 1.2 -1.4 -1.6 -1.1 -1.2 -1.1
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.2 -1.7 -1.0 -0.1 1.5 -1.8 -1.5 -1.3 -1.0 -1.5
Blood clot in the leg (DVT) 0.1 0.2 0.9 0.0 -0.5 1.0 -0.1 -0.2 -0.4 -0.0 -0.2 -0.3
Medication: Paracetamol 0.6 1.0 2.4 1.6 0.7 -0.1 -1.2 0.5 1.1 1.0 0.9 1.0
Headache pain in last month 3.5 6.1 12.0 -1.9 -2.4 -1.0 2.6 -3.5 -2.6 -2.6 -2.1 -2.7
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 0.4 -0.5 0.6 -0.6 0.3 -0.0 -0.3 -0.1 -0.2
Glaucoma (self-reported) 3.1 3.7 8.0 -1.5 -2.6 -0.2 1.5 -1.3 -1.1 -2.4 -2.8 -2.3
Gout (self-reported) 0.2 0.3 1.1 0.0 -0.7 -0.6 0.0 -1.0 -0.3 -0.3 -0.6 -0.2
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 2.9 0.8 1.7 -1.7 -0.6 1.2 0.6 1.4 1.6 1.2
Medication: Amlodipine 0.4 0.5 1.9 -0.9 0.6 -1.4 1.0 -0.1 -0.4 0.3 0.6 0.2
Medication: Ventolin 100micrograms inhaler 1.4 1.8 3.1 -1.6 -1.8 -0.0 1.6 -0.8 -1.4 -1.2 -1.5 -1.2
Birth weight 0.3 0.6 3.0 -0.3 -0.0 0.1 -0.2 1.7 1.3 0.5 0.2 0.6
Chronic bronchitis/emphysema (mother) 2.5 3.0 5.4 1.6 1.9 -0.1 -1.6 1.5 2.3 1.9 1.7 1.8
High blood pressure (siblings) 2.8 4.1 7.2 1.3 2.1 0.4 -1.5 2.7 2.3 2.4 1.9 2.5
Forced vital capacity (FVC), Best measure 1.0 3.5 8.9 1.9 0.8 0.6 -2.1 2.5 3.0 1.6 1.1 1.9
Body fat percentage 3.2 12.5 21.2 -3.2 -4.2 1.6 2.4 -3.0 -3.0 -4.6 -4.0 -4.5
Leg fat percentage (right) 2.3 8.3 15.5 -2.3 -3.7 1.3 1.5 -2.1 -2.0 -3.9 -3.6 -3.7
Arm fat-free mass (right) 0.9 4.4 13.6 2.1 1.2 -0.2 -2.4 2.7 3.7 1.5 0.9 1.9
Exposure to tobacco smoke outside home 1.4 1.8 5.5 1.6 0.6 0.6 -1.4 2.3 2.1 0.6 0.4 0.8
Comparative body size at age 10 1.5 4.1 5.9 -1.9 -2.4 0.3 1.5 -1.8 -2.4 -2.4 -2.2 -2.3
Number of full brothers 0.2 0.3 0.9 -0.7 -0.4 1.0 0.7 0.2 -0.0 0.3 -0.2 0.3
Worry too long after embarrassment 0.4 0.8 3.4 0.1 0.7 -0.0 0.1 -1.8 -1.5 0.1 0.8 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 3.8 4.9 8.3 1.9 2.9 -1.0 -1.4 2.6 1.5 2.7 2.5 2.6
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 -1.1 -0.6 -1.5 1.4 0.3 -0.6 -0.4 -0.9 -0.6
Number of children fathered 1.1 1.2 4.6 -1.3 -0.1 -2.2 1.2 -0.9 -1.1 -0.4 -0.5 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.4 -1.1 0.2 -0.3 1.6 -0.1 -1.1 0.8 0.4 0.4
Age at first live birth 0.2 0.3 2.1 0.0 0.4 -1.5 0.2 -0.7 0.3 0.0 -0.2 0.3
Pulse wave peak to peak time 0.2 0.3 1.4 -0.3 -0.6 1.2 0.1 -0.3 0.5 -0.3 -0.2 -0.4
Health satisfaction 0.4 0.5 1.1 1.0 0.7 -0.6 -0.9 -0.2 0.3 0.8 0.8 0.7
Shortness of breath walking on level ground 1.2 1.4 2.4 -0.5 -1.6 -0.8 0.6 -1.1 -1.3 -1.3 -1.5 -1.4
Qualifications: College or University degree 2.6 8.3 16.8 -2.8 -3.1 0.5 2.4 -4.1 -3.3 -2.8 -3.0 -2.7
Eye problems/disorders: None of the above 0.9 1.1 2.6 1.0 1.4 -1.6 -0.8 0.0 0.7 0.8 1.1 0.9
Mouth/teeth dental problems: Loose teeth 1.3 1.6 3.9 -0.8 -1.8 -0.6 1.1 0.7 -0.3 -1.3 -2.0 -1.5
Emphysema/chronic bronchitis 1.1 1.3 3.0 1.0 1.4 -1.6 -0.5 1.7 1.0 0.8 0.8 0.8
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 -1.0 0.1 0.1 0.9 0.8 -0.3 0.3 0.2 0.3
Neck or shoulder pain in last month 1.7 2.4 5.5 2.4 1.3 -0.8 -2.0 1.6 1.3 1.4 1.4 1.3
Medication: Blood pressure 0.3 0.4 1.5 -1.2 0.3 -0.2 1.1 -0.9 -0.4 0.4 0.2 0.2
Angina (self-reported) 1.1 1.4 5.2 0.5 1.5 -2.3 -0.1 1.0 0.9 1.2 1.0 1.1
Migraine (self-reported) 1.4 1.8 3.8 -1.7 -1.6 0.4 1.4 -1.4 -0.3 -1.1 -2.0 -1.0
Medication: Ibuprofen 0.6 0.7 1.8 1.3 -0.1 -0.9 -1.1 0.4 1.3 -0.5 -0.6 -0.3
Medication: Allopurinol 0.5 0.7 2.8 0.6 0.6 -1.7 -0.5 -0.1 0.6 0.8 0.4 0.9
Medication: Omeprazole 0.9 1.1 2.2 -0.9 -1.5 0.9 0.5 -1.3 -0.4 -1.1 -1.2 -1.1
Medication: Seretide 50 evohaler 0.6 0.7 2.3 -0.3 0.8 -1.5 0.5 -0.3 -0.3 1.0 1.0 1.0
Mean time to correctly identify matches 1.2 2.2 4.5 -1.3 -1.1 -1.9 1.9 -2.1 -2.0 -0.5 -0.8 -0.9
Heart disease (mother) 0.4 0.5 2.9 -0.3 0.4 -1.7 0.7 0.5 -0.3 0.7 0.3 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.4 -0.1 -0.4 0.8 -0.0 1.2 0.2 0.2 0.3 0.2
Whole body fat mass 1.5 6.4 12.2 -2.2 -3.2 1.3 1.4 -1.8 -1.7 -3.5 -3.1 -3.3
Leg fat mass (right) 1.6 6.0 11.8 -1.8 -3.4 1.5 1.0 -1.5 -1.1 -3.4 -3.3 -3.2
Arm predicted mass (right) 0.7 3.8 11.4 2.1 1.1 -0.3 -2.3 2.5 3.4 1.4 0.8 1.7
Pulse rate, automated reading 2.4 7.8 13.8 -2.1 -2.2 -0.5 2.1 -3.7 -3.3 -3.5 -2.6 -3.5
Alcohol intake frequency. 0.3 0.6 1.6 1.3 0.4 0.5 -1.0 0.7 1.3 0.2 0.4 0.5
Comparative height size at age 10 1.8 9.9 17.5 3.0 2.8 0.6 -3.3 3.6 4.2 3.3 2.8 3.5
Number of full sisters 0.4 0.5 3.6 -0.0 0.1 1.9 -0.2 0.2 0.2 0.4 0.7 0.4
Suffer from ‘nerves’ 2.9 4.5 9.6 2.0 3.1 -0.9 -1.4 1.5 0.9 2.6 2.9 2.4
Overall health rating 0.5 1.1 2.5 -1.0 -0.9 0.2 0.9 -0.9 -1.3 -1.3 -0.7 -1.6
Chest pain or discomfort 0.8 1.2 2.2 -1.2 -1.4 -0.1 1.5 -0.1 -0.4 -1.1 -1.4 -1.2
Had major operations 0.8 0.9 1.6 -0.7 -0.2 -1.3 0.6 -1.3 -1.1 -1.1 -0.8 -1.1
Age at last live birth 0.3 0.4 1.7 -0.8 0.0 -1.3 0.9 -0.3 0.2 -0.2 -0.5 0.0
Family relationship satisfaction 0.4 0.5 2.8 0.6 0.2 0.5 -0.7 -1.7 0.3 0.6 0.5 0.5
Leg pain on walking 0.7 0.9 1.8 -0.7 -1.3 0.4 0.7 -0.7 -0.9 -1.1 -1.3 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.0 1.3 1.2 -1.2 -1.2 1.4 1.4 0.5 0.6 0.6
Commuting to job workplace: Car/motor vehicle 0.1 0.2 1.2 -0.1 0.2 -0.4 0.1 1.1 0.2 -0.1 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.1 0.3 -0.4 -0.0 0.5 -0.4 -0.2 0.2 -0.1
Medication: Aspirin 1.4 1.8 3.6 -0.8 -0.8 -1.9 1.1 -1.7 -1.7 -1.2 -1.0 -1.5
Supplements: Vitamin C 0.5 0.6 1.1 -1.0 -0.9 -0.8 0.9 -0.0 -0.6 -0.5 -1.0 -0.5
Knee pain experienced in last month 0.2 0.3 0.8 0.0 -0.6 0.3 0.1 -0.1 -0.3 -0.8 -0.5 -0.9
Hypertension (Self-reported) 0.7 2.0 5.0 0.4 1.8 -1.3 0.0 0.2 0.2 2.2 2.2 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 -0.1 0.3 -0.1 0.3 0.1 0.6 0.0 0.2 0.1
Illnesses of father: Heart disease 3.9 5.3 7.3 2.3 2.4 0.5 -2.4 2.2 2.2 2.7 2.5 2.7
Illnesses of siblings: Diabetes 0.2 0.2 1.5 -0.5 -0.4 1.2 0.3 0.1 -0.3 0.1 0.1 0.0
Smoking status: Previous 0.3 0.5 2.0 -0.1 1.0 -0.2 0.3 -0.4 -0.2 0.9 1.4 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 8.2 1.4 1.6 2.1 -2.2 2.5 2.9 1.4 1.7 1.8
Whole body fat-free mass 0.7 4.3 11.8 2.1 1.4 -0.7 -2.3 2.7 3.4 1.6 1.1 1.9
Leg fat-free mass (right) 0.2 1.2 4.4 1.1 0.5 -0.7 -1.2 1.5 2.1 0.6 0.3 0.7
Arm fat percentage (left) 3.6 14.3 24.6 -3.5 -4.3 0.8 2.9 -3.0 -3.5 -5.0 -4.4 -4.9
Average weekly red wine intake 0.7 1.0 3.1 -1.8 -1.1 0.0 1.4 -0.1 -1.1 -0.7 -0.9 -0.6
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.1 1.3 0.6 1.8 -1.5 1.5 1.7 1.0 1.2 1.1
Mood swings 0.2 0.4 1.9 -0.5 0.3 0.2 0.9 -0.0 -1.4 -0.2 0.6 -0.5
Loneliness, isolation 0.7 1.0 3.4 -0.8 -0.5 0.9 0.7 -1.8 -1.2 -0.8 -0.3 -1.0
Long-standing illness, disability or infirmity 0.2 0.3 1.5 0.3 -0.7 -0.1 -0.4 -1.2 -0.5 -0.3 -0.5 -0.5
Ever had bowel cancer screening 0.5 0.6 1.6 -0.2 1.2 -1.3 0.3 0.4 -0.0 0.8 1.0 0.8
Diabetes diagnosed by doctor 4.1 6.7 12.2 -1.8 -2.5 -0.0 1.7 -2.9 -2.6 -3.5 -2.9 -3.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.2 0.1 -1.0 0.8 -0.2 -0.1 0.7 -0.2 -1.1 -0.2
Friendships satisfaction 1.6 2.0 9.0 -0.4 -1.2 1.0 0.4 -3.0 -1.0 -1.3 -1.2 -1.4
Qualifications: nursing, teaching 0.9 1.4 4.0 -0.6 -1.1 -1.6 0.6 -2.0 -0.9 -1.0 -1.1 -0.9
Commuting to job workplace: Walk 1.0 1.0 2.2 1.3 1.5 -0.2 -1.1 -0.1 0.9 1.0 1.2 0.9
Eye problems/disorders: Cataract 0.5 0.6 1.4 0.5 0.7 0.9 -0.6 1.0 -0.2 0.9 1.2 0.6
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 1.7 -0.2 0.1 -1.3 0.4 0.4 -0.1 -0.1 -0.1 -0.1
Medication for cholesterol 0.1 0.2 0.5 0.3 -0.5 0.6 -0.5 0.0 0.7 -0.2 -0.4 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.2 -1.0 -0.2 -1.1 1.1 -1.0 -1.0 0.1 0.1 -0.1
Back pain experienced in last month 2.5 3.6 9.2 3.0 1.8 -0.9 -2.8 1.1 2.0 1.4 1.5 1.3
Mineral and other dietary supplements 2.3 3.1 5.6 -1.5 -2.4 0.1 1.7 -1.7 -1.5 -2.0 -2.2 -1.8
Breast cancer (self-reported) 0.4 0.5 3.4 -0.1 -0.1 0.2 0.3 -1.8 -0.7 -0.2 -0.1 -0.4
Asthma (self-reported) 1.0 2.0 3.2 -1.5 -1.8 0.3 1.7 -0.6 -1.3 -1.5 -1.7 -1.4
Osteoporosis (self-reported) 0.5 0.6 1.8 1.3 0.6 -1.2 -0.8 -0.4 0.8 0.4 0.5 0.3
Osteoarthritis (self-reported) 0.9 1.2 2.6 -0.6 -0.9 -1.3 0.7 -1.6 -1.1 -1.0 -1.3 -1.1
Medication: Aspirin 1.1 1.4 5.3 -0.4 -0.4 -2.3 0.9 -1.2 -1.6 -0.9 -0.7 -1.1
Medication: Gliclazide 0.8 0.9 2.1 0.3 -0.6 -0.8 -0.4 -1.2 -0.5 -1.5 -1.2 -1.2
Illnesses of father: None of the above (group 1) 1.1 1.3 2.9 -1.1 -1.2 0.8 1.1 -1.7 -1.2 -1.0 -0.8 -1.1
Smoking status: Current 1.9 3.0 6.1 0.8 2.5 -2.0 -0.4 2.3 1.4 1.6 2.1 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.9 0.7 0.4 1.3 -1.2 0.9 1.1 1.3 1.0 1.4
Whole body water mass 0.8 4.5 11.8 2.2 1.5 -0.7 -2.3 2.8 3.4 1.6 1.1 1.9
Leg predicted mass (right) 0.2 1.3 4.7 1.1 0.6 -0.8 -1.3 1.6 2.2 0.6 0.3 0.8
Arm fat mass (left) 1.8 7.5 14.4 -2.3 -3.4 0.9 1.8 -1.8 -2.0 -3.8 -3.5 -3.6
Number of self-reported non-cancer illnesses 0.3 0.6 1.4 -0.8 0.1 -1.2 1.1 -1.2 -0.6 -0.0 -0.3 -0.3
Average weekly champagne plus white wine intake 2.4 3.3 5.2 -1.8 -2.1 0.7 1.5 -2.3 -1.7 -2.0 -1.9 -1.9
Miserableness 0.4 0.6 2.2 -0.2 -0.6 1.5 0.2 -1.1 -1.2 -0.4 0.2 -0.6
Guilty feelings 0.7 1.0 3.3 -0.8 -0.7 0.2 1.2 -1.3 -1.8 -0.6 -0.1 -0.9
Wears glasses or contact lenses 1.0 1.2 4.3 -0.0 -1.0 -1.4 0.1 -2.1 -0.9 -0.7 -1.2 -0.9
Ever taken oral contraceptive pill 0.7 0.8 1.5 -0.9 -1.1 -1.1 1.2 0.1 -0.2 -0.7 -1.2 -0.7
Hearing aid user 0.9 1.1 1.7 -1.1 -1.1 -1.0 1.3 -0.6 -1.0 -0.9 -1.2 -0.8
Mother’s age at death 1.0 1.2 3.5 0.6 1.7 1.0 -0.9 0.0 0.0 1.2 1.9 0.9
Financial situation satisfaction 1.9 2.3 4.1 0.8 1.6 -0.2 -1.0 1.6 2.0 1.8 1.8 1.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.3 -0.3 0.9 -0.1 0.2 1.1 0.0 0.9 1.0 1.0
Commuting to job workplace: Public transport 0.5 0.5 1.4 0.4 1.2 0.1 -0.7 0.6 0.4 0.7 1.1 0.7
Eye problems/disorders: Glaucoma 4.1 4.9 10.5 -2.0 -2.9 0.3 2.0 -1.1 -1.4 -2.8 -3.2 -2.5
Medication: Blood pressure 0.7 1.3 5.6 0.6 1.3 -2.4 -0.2 0.6 0.1 1.1 1.2 0.8
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.7 0.7 -1.1 0.4 -0.5 -0.4 -0.4 -1.3 -1.1 -1.2
Supplements: Fish oil (including cod liver oil) 2.8 3.6 5.9 1.9 2.4 0.2 -2.1 1.6 1.9 2.1 2.1 2.0
High cholesterol (Self-reported) 0.6 1.0 2.3 -0.7 -0.3 -1.5 1.0 -1.0 -0.9 -1.1 -0.8 -1.3
Medication: Bendroflumethiazide 3.3 4.9 7.8 2.3 1.9 -0.3 -2.5 2.5 2.8 2.4 1.8 2.5
Medication: Paracetamol 0.4 0.6 1.5 1.2 0.3 -0.1 -0.8 1.0 0.8 0.8 0.7 0.7
Medication: Lisinopril 0.4 0.5 2.4 -0.1 -0.0 -1.6 0.8 -0.5 -0.3 -0.4 -0.5 -0.5
Medication: Atorvastatin 0.9 1.2 4.0 0.9 0.9 -2.0 -0.3 1.4 1.2 0.8 0.5 0.7
Illnesses of father: High blood pressure 0.8 1.0 3.5 0.5 0.9 -1.9 -0.1 1.8 0.3 0.7 0.6 0.7
Alcohol drinker status: Never 0.1 0.1 0.4 0.2 0.2 -0.7 -0.1 0.1 0.2 -0.1 -0.1 0.1
Ever smoked 0.7 1.2 2.7 0.4 1.6 -1.6 -0.1 1.1 0.1 1.2 1.6 0.6
Basal metabolic rate 0.4 2.2 7.6 1.6 0.7 -0.3 -1.8 2.0 2.8 0.8 0.5 1.1
Leg fat percentage (left) 2.4 8.6 15.1 -2.5 -3.6 1.1 1.8 -2.5 -2.4 -3.9 -3.5 -3.8
Arm fat-free mass (left) 0.8 4.1 12.2 2.3 1.1 0.0 -2.6 2.5 3.5 1.4 0.9 1.7
Number of operations (self-reported) 0.2 0.3 2.2 -0.0 0.0 -1.5 -0.1 -0.2 0.0 -0.0 -0.3 -0.1
Average weekly beer plus cider intake 1.0 1.5 6.2 -0.9 -1.1 2.5 0.5 -0.2 -0.4 -1.2 -1.2 -1.2
Irritability 0.7 1.1 3.1 -1.3 -0.3 -1.2 1.7 -0.0 -1.8 -0.6 -0.2 -0.8
Risk taking 1.3 1.9 4.8 1.3 1.1 -0.5 -1.1 2.2 1.7 1.5 0.6 1.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.3 -0.1 1.1 -0.8 0.2 0.7 -0.1 1.4 1.5 1.2
Fractured/broken bones in last 5 years 0.4 0.5 1.0 0.0 -1.0 0.6 -0.1 -0.3 -0.9 -0.9 -0.8 -0.9
Age started oral contraceptive pill 0.2 0.3 1.1 0.6 -0.3 -1.0 -0.1 -0.1 0.4 -0.5 -0.6 -0.4
Diastolic blood pressure, automated reading 0.8 2.4 3.5 1.7 1.7 -1.2 -1.3 0.7 1.5 1.9 1.7 1.8
Ever depressed for a whole week 5.0 6.1 9.7 3.1 1.7 0.1 -3.1 3.1 2.7 2.3 2.2 2.5
Unable to work because of sickness or disability 1.7 2.2 2.8 1.6 1.6 -1.1 -1.5 1.4 1.7 1.5 1.2 1.6
Commuting to job workplace: Cycle 1.5 1.8 4.6 -1.4 0.3 -1.5 1.6 -2.0 -2.1 -0.0 -0.2 -0.4
Myopia 0.7 1.0 4.5 -0.3 0.3 -1.1 0.5 -2.1 -1.6 -0.1 0.7 -0.5
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.3 0.1 -1.7 1.5 -0.5 0.3 0.3 -1.6 -1.8 -1.2
Cholesterol lowering medication 1.6 2.4 3.7 -1.1 -1.3 -1.0 1.4 -1.8 -1.9 -1.7 -1.4 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.3 -0.1 -1.0 0.5 -0.1 -0.3 0.3 -0.6 -1.1 -0.6
Pain experienced in last month 0.2 0.4 1.6 -1.3 0.3 0.4 0.8 0.7 0.0 0.4 0.2 0.4
Supplements: Calcium 0.2 0.2 0.6 0.5 0.5 -0.8 -0.3 -0.3 -0.4 0.4 0.3 0.2
Basal cell carcinoma (self-reported) 0.3 0.3 0.8 -0.9 0.5 -0.1 0.6 0.6 -0.0 0.6 0.6 0.5
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.3 -0.0 0.2 0.1 0.5 -0.5 0.2 0.1 0.1
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.3 0.1 -0.2 0.6 -0.1 0.0 -0.1 0.3 0.1 0.0
Heart disease (siblings) 0.1 0.2 0.4 -0.4 0.1 -0.1 0.6 0.0 -0.6 0.6 0.4 0.3
Alcohol drinker status: Previous 3.7 4.3 6.1 -2.5 -2.5 0.5 2.5 -1.6 -2.4 -1.9 -1.8 -2.1
Pack years of smoking 0.2 0.3 0.7 -0.2 -0.0 -0.8 0.4 0.7 -0.2 -0.5 -0.6 -0.6
Impedance of whole body 0.2 1.0 4.0 -0.9 0.5 2.0 0.2 -1.2 -1.2 0.1 0.9 -0.1
Leg fat mass (left) 1.4 5.5 10.5 -1.9 -3.2 1.3 1.1 -1.6 -1.2 -3.2 -3.1 -3.0
Arm predicted mass (left) 0.7 3.7 11.1 2.1 1.0 -0.0 -2.4 2.6 3.3 1.3 0.7 1.6