[Hub]/) : Traits : Hand grip strength (right) :

chr1:204,982,713-206,329,620

Best TWAS P=8.2e-17 · Best GWAS P=1.37e-16 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PM20D1 0.27 0.41 enet 15 0.41 7.8e-54 -7.6 -7.6 3.2e-14 0.92 0.37 0.63 FALSE
2 CommonMind Brain Pre-frontal Cortex RAB7L1 0.07 0.03 enet 16 0.05 4.1e-07 5.2 -6.4 1.8e-10 0.74 0.03 0.97 FALSE
3 CommonMind Brain Pre-frontal Cortex SLC26A9 0.13 0.16 lasso 3 0.16 3.1e-19 -7.6 -7.7 1.5e-14 0.89 0.08 0.92 FALSE
4 GTEx Adipose Subcutaneous NUCKS1 0.11 0.10 lasso 3 0.08 9.4e-07 -8.3 8.2 2.0e-16 -1.00 0.00 1.00 FALSE
5 GTEx Adipose Subcutaneous RAB7L1 0.20 0.09 lasso 4 0.18 7.6e-15 4.5 -5.4 7.2e-08 0.60 0.98 0.02 FALSE
6 GTEx Adipose Visceral Omentum RAB7L1 0.17 0.08 enet 15 0.10 1.2e-05 4.4 -6.7 2.5e-11 0.68 0.08 0.91 FALSE
7 GTEx Adrenal Gland NUCKS1 0.17 0.00 enet 11 0.02 6.7e-02 -8.2 7.5 8.4e-14 -0.78 0.02 0.82 FALSE
8 GTEx Artery Aorta NUCKS1 0.14 0.11 lasso 3 0.08 3.7e-05 -8.2 8.2 3.5e-16 -0.94 0.01 0.99 FALSE
9 GTEx Artery Aorta RAB7L1 0.43 0.20 lasso 8 0.29 1.9e-16 7.2 -6.7 2.6e-11 0.72 0.31 0.69 FALSE
10 GTEx Artery Coronary RAB7L1 0.47 0.10 enet 55 0.19 5.5e-07 3.5 -6.3 3.6e-10 0.62 0.04 0.93 FALSE
11 GTEx Artery Tibial NUCKS1 0.13 0.03 lasso 2 0.01 4.0e-02 -8.0 7.9 3.3e-15 -0.90 0.01 0.96 FALSE
12 GTEx Artery Tibial RAB7L1 0.29 0.27 lasso 9 0.31 9.7e-25 7.2 -6.5 1.1e-10 0.74 0.66 0.34 FALSE
13 GTEx Brain Caudate basal ganglia NUCKS1 0.25 0.24 lasso 3 0.25 8.1e-08 7.1 -6.8 1.0e-11 0.76 0.04 0.92 FALSE
14 GTEx Brain Cerebellum NUCKS1 0.22 0.13 lasso 3 0.08 2.0e-03 -8.0 8.0 1.8e-15 -0.95 0.01 0.95 FALSE
15 GTEx Brain Cerebellum SLC41A1 0.27 0.09 lasso 4 0.08 2.1e-03 -7.1 -7.7 2.1e-14 0.90 0.02 0.84 FALSE
16 GTEx Brain Hippocampus NUCKS1 0.57 0.03 lasso 8 0.11 1.5e-03 -8.0 6.5 6.7e-11 -0.66 0.02 0.75 FALSE
17 GTEx Brain Putamen basal ganglia NUCKS1 0.40 0.26 lasso 4 0.27 3.2e-07 -8.3 8.2 2.3e-16 -1.00 0.00 0.99 FALSE
18 GTEx Breast Mammary Tissue NUCKS1 0.15 0.05 lasso 4 0.09 2.5e-05 -8.3 7.1 9.0e-13 -0.96 0.01 0.99 FALSE
19 GTEx Cells Transformed fibroblasts RAB7L1 0.30 0.23 enet 19 0.36 8.6e-28 2.7 -6.0 2.5e-09 0.69 0.98 0.02 FALSE
20 GTEx Colon Sigmoid NUCKS1 0.34 0.22 enet 20 0.21 8.3e-08 -8.2 7.3 3.1e-13 -0.91 0.01 0.99 FALSE
21 GTEx Esophagus Mucosa NUCKS1 0.12 0.11 enet 6 0.06 7.2e-05 7.2 7.3 2.7e-13 -0.82 0.03 0.96 FALSE
22 GTEx Esophagus Mucosa RAB7L1 0.26 0.11 enet 34 0.18 4.5e-12 7.2 -6.9 4.9e-12 0.71 0.08 0.92 FALSE
23 GTEx Esophagus Mucosa SLC41A1 0.17 0.09 enet 25 0.12 1.1e-08 -7.6 -5.5 3.8e-08 0.73 0.04 0.96 FALSE
24 GTEx Esophagus Muscularis NUCKS1 0.21 0.22 lasso 5 0.20 3.6e-12 -7.1 7.6 3.8e-14 -0.96 0.01 0.99 FALSE
25 GTEx Esophagus Muscularis RAB7L1 0.27 0.30 lasso 4 0.33 9.4e-21 4.5 -6.3 3.5e-10 0.66 0.99 0.01 FALSE
26 GTEx Heart Atrial Appendage NUCKS1 0.12 0.14 enet 4 0.08 1.7e-04 7.2 7.5 6.1e-14 -0.84 0.03 0.94 FALSE
27 GTEx Heart Atrial Appendage RAB7L1 0.20 0.17 enet 12 0.14 4.9e-07 7.2 -7.3 3.2e-13 0.83 0.02 0.98 FALSE
28 GTEx Heart Left Ventricle NUCKS1 0.10 0.04 lasso 3 0.05 1.4e-03 -8.2 8.1 6.5e-16 -0.95 0.01 0.96 FALSE
29 GTEx Lung NUCKS1 0.09 0.07 lasso 3 0.04 2.6e-04 -8.3 7.8 6.2e-15 -0.98 0.01 0.99 FALSE
30 GTEx Lung RAB7L1 0.34 0.19 enet 53 0.31 7.5e-24 4.1 -7.1 9.3e-13 0.74 0.12 0.88 FALSE
31 GTEx Muscle Skeletal RAB7L1 0.16 0.14 lasso 8 0.15 2.9e-14 4.5 -5.8 8.0e-09 0.64 0.88 0.12 FALSE
32 GTEx Nerve Tibial NUCKS1 0.25 0.21 enet 16 0.22 7.3e-16 -8.1 8.3 8.2e-17 -0.97 0.01 0.99 TRUE
33 GTEx Nerve Tibial RAB7L1 0.35 0.14 enet 68 0.22 1.8e-15 3.5 -5.5 4.8e-08 0.60 0.82 0.18 FALSE
34 GTEx Nerve Tibial SLC41A1 0.12 0.02 lasso 4 0.05 2.5e-04 -7.6 -6.7 2.9e-11 0.83 0.01 0.98 FALSE
35 GTEx Pancreas NUCKS1 0.16 0.00 lasso 4 0.00 4.5e-01 6.4 7.4 1.4e-13 -0.87 0.02 0.86 FALSE
36 GTEx Pancreas RAB7L1 0.18 0.06 enet 12 0.06 1.1e-03 7.2 -6.5 1.1e-10 0.58 0.15 0.43 FALSE
37 GTEx Pancreas SLC41A1 0.24 0.21 lasso 5 0.19 1.4e-08 -7.6 -7.6 3.7e-14 0.90 0.14 0.85 FALSE
38 GTEx Pituitary NUCKS1 0.26 0.19 lasso 2 0.20 7.6e-06 -7.1 7.3 3.7e-13 -0.95 0.01 0.96 FALSE
39 GTEx Prostate NUCKS1 0.38 0.23 lasso 8 0.32 7.5e-09 5.1 -6.5 9.6e-11 0.80 0.02 0.96 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic NUCKS1 0.20 0.14 lasso 4 0.13 2.0e-07 -8.3 7.9 2.8e-15 -0.99 0.01 0.99 FALSE
41 GTEx Skin Sun Exposed Lower leg NUCKS1 0.20 0.26 lasso 5 0.26 1.5e-21 -8.3 8.2 1.6e-16 -1.00 0.00 1.00 FALSE
42 GTEx Stomach NUCKS1 0.21 0.11 lasso 8 0.15 1.1e-07 -7.1 6.8 8.7e-12 -0.88 0.01 0.99 FALSE
43 GTEx Testis NUCKS1 0.16 0.16 enet 15 0.16 1.3e-07 -8.1 8.0 9.2e-16 -0.92 0.01 0.99 FALSE
44 GTEx Testis RAB7L1 0.41 0.21 lasso 13 0.26 9.2e-12 4.5 -5.7 9.2e-09 0.59 0.98 0.01 FALSE
45 GTEx Thyroid NUCKS1 0.26 0.16 lasso 6 0.19 1.8e-14 -8.0 8.3 1.5e-16 -0.95 0.01 0.99 FALSE
46 GTEx Thyroid SLC41A1 0.06 0.00 enet 10 0.02 1.5e-02 -7.6 -6.8 9.4e-12 0.66 0.03 0.74 FALSE
47 GTEx Whole Blood RAB7L1 0.14 0.11 lasso 5 0.10 3.1e-09 3.7 -5.2 2.2e-07 0.52 0.77 0.23 FALSE
48 METSIM Adipose NUCKS1 0.05 0.02 lasso 6 0.01 4.3e-03 -8.1 7.8 5.2e-15 -0.91 0.01 0.98 FALSE
49 METSIM Adipose PM20D1 0.25 0.30 bslmm 377 0.31 8.4e-47 -7.6 6.7 2.1e-11 -0.87 0.37 0.63 FALSE
50 METSIM Adipose RAB7L1 0.08 0.04 bslmm 401 0.05 8.6e-08 7.1 -5.2 2.7e-07 0.54 0.91 0.08 FALSE
51 METSIM Adipose SLC41A1 0.07 0.08 lasso 7 0.08 1.9e-11 5.1 -5.2 2.6e-07 0.73 0.74 0.26 FALSE
52 YFS Blood NUCKS1 0.15 0.24 lasso 4 0.25 1.4e-80 -8.3 8.3 1.1e-16 -0.97 0.00 1.00 FALSE
53 YFS Blood RAB7L1 0.06 0.07 lasso 6 0.06 1.1e-19 7.1 -7.5 9.0e-14 0.84 0.84 0.16 FALSE
54 YFS Blood SLC41A1 0.06 0.05 enet 15 0.05 2.6e-17 -8.0 -7.3 2.8e-13 0.90 0.02 0.98 FALSE
55 The Cancer Genome Atlas Bladder Urothelial Carcinoma PM20D1 0.22 0.26 lasso 5 0.26 1.7e-22 -8.0 7.6 2.2e-14 -0.91 0.00 1.00 FALSE
56 The Cancer Genome Atlas Breast Invasive Carcinoma PM20D1 0.24 0.37 lasso 5 0.39 4.9e-85 -7.6 7.1 1.6e-12 -0.87 0.04 0.96 FALSE
57 The Cancer Genome Atlas Breast Invasive Carcinoma RAB7L1 0.02 0.02 enet 5 0.02 3.1e-04 3.5 -5.3 1.4e-07 0.62 0.33 0.42 FALSE
58 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PM20D1 0.18 0.19 blup 47 0.18 1.9e-09 -7.6 6.9 5.6e-12 -0.80 0.01 0.99 FALSE
59 The Cancer Genome Atlas Colon Adenocarcinoma PM20D1 0.26 0.13 enet 14 0.16 9.7e-10 5.1 6.2 5.0e-10 -0.72 0.03 0.97 FALSE
60 The Cancer Genome Atlas Colon Adenocarcinoma RAB7L1 0.17 0.14 blup 46 0.14 1.7e-08 -8.1 -6.5 8.6e-11 0.81 0.01 0.99 FALSE
61 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PM20D1 0.19 0.25 lasso 5 0.25 3.0e-28 -7.6 7.4 1.2e-13 -0.90 0.00 1.00 FALSE
62 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RAB7L1 0.09 0.13 lasso 6 0.13 3.6e-14 5.2 -6.7 1.9e-11 0.76 0.58 0.42 FALSE
63 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PM20D1 0.29 0.35 enet 18 0.35 5.1e-41 -7.6 6.9 4.1e-12 -0.85 0.04 0.96 FALSE
64 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB7L1 0.09 0.08 enet 11 0.08 1.7e-09 7.1 -6.2 7.6e-10 0.76 0.42 0.58 FALSE
65 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PM20D1 0.19 0.19 enet 4 0.19 4.5e-11 -7.6 7.7 1.8e-14 -0.92 0.00 1.00 FALSE
66 The Cancer Genome Atlas Brain Lower Grade Glioma PM20D1 0.41 0.43 enet 20 0.44 9.2e-55 -7.6 7.2 7.1e-13 -0.87 0.04 0.96 FALSE
67 The Cancer Genome Atlas Brain Lower Grade Glioma RAB7L1 0.09 0.08 lasso 2 0.07 1.1e-08 7.1 -7.0 1.9e-12 0.77 0.92 0.08 FALSE
68 The Cancer Genome Atlas Lung Adenocarcinoma PM20D1 0.31 0.39 enet 16 0.41 5.1e-52 -7.6 7.5 8.4e-14 -0.89 0.00 1.00 FALSE
69 The Cancer Genome Atlas Lung Adenocarcinoma RAB7L1 0.02 0.02 enet 5 0.03 4.6e-04 5.2 -5.7 1.2e-08 0.69 0.02 0.56 FALSE
70 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PM20D1 0.26 0.34 lasso 3 0.34 1.9e-40 -7.6 6.9 4.0e-12 -0.88 0.04 0.96 FALSE
71 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RAB7L1 0.06 0.05 enet 6 0.06 2.6e-07 3.5 -5.4 5.3e-08 0.66 0.58 0.37 FALSE
72 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PM20D1 0.12 0.13 blup 47 0.12 9.1e-09 -7.6 6.5 1.1e-10 -0.82 0.01 0.99 FALSE
73 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RAB7L1 0.06 0.06 blup 46 0.06 5.2e-05 -8.2 -7.7 1.3e-14 0.92 0.01 0.99 FALSE
74 The Cancer Genome Atlas Pancreatic Adenocarcinoma PM20D1 0.32 0.34 lasso 2 0.34 9.7e-15 -8.0 8.0 1.9e-15 -0.93 0.00 1.00 FALSE
75 The Cancer Genome Atlas Pancreatic Adenocarcinoma RAB7L1 0.09 0.04 blup 46 0.04 1.2e-02 7.1 -7.5 4.5e-14 0.84 0.02 0.91 FALSE
76 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PM20D1 0.34 0.13 enet 20 0.21 9.7e-09 3.4 5.2 1.8e-07 -0.73 0.02 0.98 FALSE
77 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RAB7L1 0.17 0.13 lasso 2 0.11 4.4e-05 7.2 -7.2 7.8e-13 0.76 0.06 0.74 FALSE
78 The Cancer Genome Atlas Prostate Adenocarcinoma NUCKS1 0.04 0.05 lasso 2 0.03 1.5e-04 -8.2 8.0 1.2e-15 -0.96 0.00 0.99 FALSE
79 The Cancer Genome Atlas Prostate Adenocarcinoma PM20D1 0.16 0.14 enet 15 0.16 5.6e-16 -7.6 6.7 2.0e-11 -0.83 0.03 0.97 FALSE
80 The Cancer Genome Atlas Prostate Adenocarcinoma RAB7L1 0.12 0.12 lasso 2 0.12 3.8e-12 7.2 -7.0 1.8e-12 0.74 0.91 0.09 FALSE
81 The Cancer Genome Atlas Rectum Adenocarcinoma PM20D1 0.17 0.02 blup 47 0.01 2.2e-01 -8.0 5.9 2.8e-09 -0.79 0.00 0.76 FALSE
82 The Cancer Genome Atlas Soft Tissue Sarcoma PM20D1 0.23 0.24 lasso 4 0.24 1.2e-14 -7.6 7.2 6.6e-13 -0.89 0.00 1.00 FALSE
83 The Cancer Genome Atlas Skin Cutaneous Melanoma PM20D1 0.17 0.11 lasso 3 0.07 5.0e-03 -7.6 7.5 6.6e-14 -0.90 0.00 0.86 FALSE
84 The Cancer Genome Atlas Stomach Adenocarcinoma PM20D1 0.09 0.11 enet 6 0.10 1.3e-07 5.1 5.5 5.0e-08 -0.75 0.04 0.96 FALSE
85 The Cancer Genome Atlas Stomach Adenocarcinoma RAB7L1 0.07 0.04 blup 46 0.07 1.2e-05 -8.0 -7.0 2.1e-12 0.78 0.03 0.94 FALSE
86 The Cancer Genome Atlas Testicular Germ Cell Tumors PM20D1 0.42 0.34 lasso 3 0.34 6.9e-13 -7.6 7.4 1.2e-13 -0.84 0.02 0.98 FALSE
87 The Cancer Genome Atlas Testicular Germ Cell Tumors SLC41A1 0.13 0.03 blup 55 0.03 2.6e-02 -8.1 7.1 1.4e-12 -0.83 0.01 0.92 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma NUCKS1 0.07 0.07 blup 59 0.07 1.3e-07 -8.0 6.2 6.1e-10 -0.90 0.01 0.99 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma PM20D1 0.26 0.40 lasso 4 0.41 2.0e-42 -7.6 7.4 1.3e-13 -0.90 0.01 0.99 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma RAB7L1 0.13 0.17 enet 15 0.21 3.6e-20 7.2 -7.7 1.0e-14 0.88 0.02 0.98 FALSE
91 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma NUCKS1 0.11 0.02 blup 58 0.09 1.9e-03 3.5 6.8 9.1e-12 -0.79 0.02 0.55 FALSE
92 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma PM20D1 0.19 0.09 lasso 4 0.12 4.2e-04 -8.0 7.3 2.4e-13 -0.87 0.00 0.96 FALSE