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chr1:204,982,713-206,329,620

Best TWAS P=8.2e-17 · Best GWAS P=1.37e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	GTEx	Nerve Tibial	NUCKS1	0.25	0.21	enet	16	0.22	7.3e-16	-8.1	8.3	8.2e-17	-0.97	0.01	0.99	TRUE
52	YFS	Blood	NUCKS1	0.15	0.24	lasso	4	0.25	1.4e-80	-8.3	8.3	1.1e-16	-0.97	0.00	1.00	FALSE
45	GTEx	Thyroid	NUCKS1	0.26	0.16	lasso	6	0.19	1.8e-14	-8.0	8.3	1.5e-16	-0.95	0.01	0.99	FALSE
41	GTEx	Skin Sun Exposed Lower leg	NUCKS1	0.20	0.26	lasso	5	0.26	1.5e-21	-8.3	8.2	1.6e-16	-1.00	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	NUCKS1	0.11	0.10	lasso	3	0.08	9.4e-07	-8.3	8.2	2.0e-16	-1.00	0.00	1.00	FALSE
17	GTEx	Brain Putamen basal ganglia	NUCKS1	0.40	0.26	lasso	4	0.27	3.2e-07	-8.3	8.2	2.3e-16	-1.00	0.00	0.99	FALSE
8	GTEx	Artery Aorta	NUCKS1	0.14	0.11	lasso	3	0.08	3.7e-05	-8.2	8.2	3.5e-16	-0.94	0.01	0.99	FALSE
28	GTEx	Heart Left Ventricle	NUCKS1	0.10	0.04	lasso	3	0.05	1.4e-03	-8.2	8.1	6.5e-16	-0.95	0.01	0.96	FALSE
43	GTEx	Testis	NUCKS1	0.16	0.16	enet	15	0.16	1.3e-07	-8.1	8.0	9.2e-16	-0.92	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCKS1	0.04	0.05	lasso	2	0.03	1.5e-04	-8.2	8.0	1.2e-15	-0.96	0.00	0.99	FALSE
14	GTEx	Brain Cerebellum	NUCKS1	0.22	0.13	lasso	3	0.08	2.0e-03	-8.0	8.0	1.8e-15	-0.95	0.01	0.95	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PM20D1	0.32	0.34	lasso	2	0.34	9.7e-15	-8.0	8.0	1.9e-15	-0.93	0.00	1.00	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	NUCKS1	0.20	0.14	lasso	4	0.13	2.0e-07	-8.3	7.9	2.8e-15	-0.99	0.01	0.99	FALSE
11	GTEx	Artery Tibial	NUCKS1	0.13	0.03	lasso	2	0.01	4.0e-02	-8.0	7.9	3.3e-15	-0.90	0.01	0.96	FALSE
48	METSIM	Adipose	NUCKS1	0.05	0.02	lasso	6	0.01	4.3e-03	-8.1	7.8	5.2e-15	-0.91	0.01	0.98	FALSE
29	GTEx	Lung	NUCKS1	0.09	0.07	lasso	3	0.04	2.6e-04	-8.3	7.8	6.2e-15	-0.98	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	RAB7L1	0.13	0.17	enet	15	0.21	3.6e-20	7.2	-7.7	1.0e-14	0.88	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB7L1	0.06	0.06	blup	46	0.06	5.2e-05	-8.2	-7.7	1.3e-14	0.92	0.01	0.99	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC26A9	0.13	0.16	lasso	3	0.16	3.1e-19	-7.6	-7.7	1.5e-14	0.89	0.08	0.92	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PM20D1	0.19	0.19	enet	4	0.19	4.5e-11	-7.6	7.7	1.8e-14	-0.92	0.00	1.00	FALSE
15	GTEx	Brain Cerebellum	SLC41A1	0.27	0.09	lasso	4	0.08	2.1e-03	-7.1	-7.7	2.1e-14	0.90	0.02	0.84	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PM20D1	0.22	0.26	lasso	5	0.26	1.7e-22	-8.0	7.6	2.2e-14	-0.91	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PM20D1	0.27	0.41	enet	15	0.41	7.8e-54	-7.6	-7.6	3.2e-14	0.92	0.37	0.63	FALSE
37	GTEx	Pancreas	SLC41A1	0.24	0.21	lasso	5	0.19	1.4e-08	-7.6	-7.6	3.7e-14	0.90	0.14	0.85	FALSE
24	GTEx	Esophagus Muscularis	NUCKS1	0.21	0.22	lasso	5	0.20	3.6e-12	-7.1	7.6	3.8e-14	-0.96	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAB7L1	0.09	0.04	blup	46	0.04	1.2e-02	7.1	-7.5	4.5e-14	0.84	0.02	0.91	FALSE
26	GTEx	Heart Atrial Appendage	NUCKS1	0.12	0.14	enet	4	0.08	1.7e-04	7.2	7.5	6.1e-14	-0.84	0.03	0.94	FALSE
83	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PM20D1	0.17	0.11	lasso	3	0.07	5.0e-03	-7.6	7.5	6.6e-14	-0.90	0.00	0.86	FALSE
7	GTEx	Adrenal Gland	NUCKS1	0.17	0.00	enet	11	0.02	6.7e-02	-8.2	7.5	8.4e-14	-0.78	0.02	0.82	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	PM20D1	0.31	0.39	enet	16	0.41	5.1e-52	-7.6	7.5	8.4e-14	-0.89	0.00	1.00	FALSE
53	YFS	Blood	RAB7L1	0.06	0.07	lasso	6	0.06	1.1e-19	7.1	-7.5	9.0e-14	0.84	0.84	0.16	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PM20D1	0.19	0.25	lasso	5	0.25	3.0e-28	-7.6	7.4	1.2e-13	-0.90	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PM20D1	0.42	0.34	lasso	3	0.34	6.9e-13	-7.6	7.4	1.2e-13	-0.84	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	PM20D1	0.26	0.40	lasso	4	0.41	2.0e-42	-7.6	7.4	1.3e-13	-0.90	0.01	0.99	FALSE
35	GTEx	Pancreas	NUCKS1	0.16	0.00	lasso	4	0.00	4.5e-01	6.4	7.4	1.4e-13	-0.87	0.02	0.86	FALSE
92	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PM20D1	0.19	0.09	lasso	4	0.12	4.2e-04	-8.0	7.3	2.4e-13	-0.87	0.00	0.96	FALSE
21	GTEx	Esophagus Mucosa	NUCKS1	0.12	0.11	enet	6	0.06	7.2e-05	7.2	7.3	2.7e-13	-0.82	0.03	0.96	FALSE
54	YFS	Blood	SLC41A1	0.06	0.05	enet	15	0.05	2.6e-17	-8.0	-7.3	2.8e-13	0.90	0.02	0.98	FALSE
20	GTEx	Colon Sigmoid	NUCKS1	0.34	0.22	enet	20	0.21	8.3e-08	-8.2	7.3	3.1e-13	-0.91	0.01	0.99	FALSE
27	GTEx	Heart Atrial Appendage	RAB7L1	0.20	0.17	enet	12	0.14	4.9e-07	7.2	-7.3	3.2e-13	0.83	0.02	0.98	FALSE
38	GTEx	Pituitary	NUCKS1	0.26	0.19	lasso	2	0.20	7.6e-06	-7.1	7.3	3.7e-13	-0.95	0.01	0.96	FALSE
82	The Cancer Genome Atlas	Soft Tissue Sarcoma	PM20D1	0.23	0.24	lasso	4	0.24	1.2e-14	-7.6	7.2	6.6e-13	-0.89	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	PM20D1	0.41	0.43	enet	20	0.44	9.2e-55	-7.6	7.2	7.1e-13	-0.87	0.04	0.96	FALSE
77	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB7L1	0.17	0.13	lasso	2	0.11	4.4e-05	7.2	-7.2	7.8e-13	0.76	0.06	0.74	FALSE
18	GTEx	Breast Mammary Tissue	NUCKS1	0.15	0.05	lasso	4	0.09	2.5e-05	-8.3	7.1	9.0e-13	-0.96	0.01	0.99	FALSE
30	GTEx	Lung	RAB7L1	0.34	0.19	enet	53	0.31	7.5e-24	4.1	-7.1	9.3e-13	0.74	0.12	0.88	FALSE
87	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SLC41A1	0.13	0.03	blup	55	0.03	2.6e-02	-8.1	7.1	1.4e-12	-0.83	0.01	0.92	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	PM20D1	0.24	0.37	lasso	5	0.39	4.9e-85	-7.6	7.1	1.6e-12	-0.87	0.04	0.96	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB7L1	0.12	0.12	lasso	2	0.12	3.8e-12	7.2	-7.0	1.8e-12	0.74	0.91	0.09	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB7L1	0.09	0.08	lasso	2	0.07	1.1e-08	7.1	-7.0	1.9e-12	0.77	0.92	0.08	FALSE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB7L1	0.07	0.04	blup	46	0.07	1.2e-05	-8.0	-7.0	2.1e-12	0.78	0.03	0.94	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PM20D1	0.26	0.34	lasso	3	0.34	1.9e-40	-7.6	6.9	4.0e-12	-0.88	0.04	0.96	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PM20D1	0.29	0.35	enet	18	0.35	5.1e-41	-7.6	6.9	4.1e-12	-0.85	0.04	0.96	FALSE
22	GTEx	Esophagus Mucosa	RAB7L1	0.26	0.11	enet	34	0.18	4.5e-12	7.2	-6.9	4.9e-12	0.71	0.08	0.92	FALSE
58	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PM20D1	0.18	0.19	blup	47	0.18	1.9e-09	-7.6	6.9	5.6e-12	-0.80	0.01	0.99	FALSE
42	GTEx	Stomach	NUCKS1	0.21	0.11	lasso	8	0.15	1.1e-07	-7.1	6.8	8.7e-12	-0.88	0.01	0.99	FALSE
91	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NUCKS1	0.11	0.02	blup	58	0.09	1.9e-03	3.5	6.8	9.1e-12	-0.79	0.02	0.55	FALSE
46	GTEx	Thyroid	SLC41A1	0.06	0.00	enet	10	0.02	1.5e-02	-7.6	-6.8	9.4e-12	0.66	0.03	0.74	FALSE
13	GTEx	Brain Caudate basal ganglia	NUCKS1	0.25	0.24	lasso	3	0.25	8.1e-08	7.1	-6.8	1.0e-11	0.76	0.04	0.92	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB7L1	0.09	0.13	lasso	6	0.13	3.6e-14	5.2	-6.7	1.9e-11	0.76	0.58	0.42	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	PM20D1	0.16	0.14	enet	15	0.16	5.6e-16	-7.6	6.7	2.0e-11	-0.83	0.03	0.97	FALSE
49	METSIM	Adipose	PM20D1	0.25	0.30	bslmm	377	0.31	8.4e-47	-7.6	6.7	2.1e-11	-0.87	0.37	0.63	FALSE
6	GTEx	Adipose Visceral Omentum	RAB7L1	0.17	0.08	enet	15	0.10	1.2e-05	4.4	-6.7	2.5e-11	0.68	0.08	0.91	FALSE
9	GTEx	Artery Aorta	RAB7L1	0.43	0.20	lasso	8	0.29	1.9e-16	7.2	-6.7	2.6e-11	0.72	0.31	0.69	FALSE
34	GTEx	Nerve Tibial	SLC41A1	0.12	0.02	lasso	4	0.05	2.5e-04	-7.6	-6.7	2.9e-11	0.83	0.01	0.98	FALSE
16	GTEx	Brain Hippocampus	NUCKS1	0.57	0.03	lasso	8	0.11	1.5e-03	-8.0	6.5	6.7e-11	-0.66	0.02	0.75	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	RAB7L1	0.17	0.14	blup	46	0.14	1.7e-08	-8.1	-6.5	8.6e-11	0.81	0.01	0.99	FALSE
39	GTEx	Prostate	NUCKS1	0.38	0.23	lasso	8	0.32	7.5e-09	5.1	-6.5	9.6e-11	0.80	0.02	0.96	FALSE
12	GTEx	Artery Tibial	RAB7L1	0.29	0.27	lasso	9	0.31	9.7e-25	7.2	-6.5	1.1e-10	0.74	0.66	0.34	FALSE
36	GTEx	Pancreas	RAB7L1	0.18	0.06	enet	12	0.06	1.1e-03	7.2	-6.5	1.1e-10	0.58	0.15	0.43	FALSE
72	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PM20D1	0.12	0.13	blup	47	0.12	9.1e-09	-7.6	6.5	1.1e-10	-0.82	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RAB7L1	0.07	0.03	enet	16	0.05	4.1e-07	5.2	-6.4	1.8e-10	0.74	0.03	0.97	FALSE
25	GTEx	Esophagus Muscularis	RAB7L1	0.27	0.30	lasso	4	0.33	9.4e-21	4.5	-6.3	3.5e-10	0.66	0.99	0.01	FALSE
10	GTEx	Artery Coronary	RAB7L1	0.47	0.10	enet	55	0.19	5.5e-07	3.5	-6.3	3.6e-10	0.62	0.04	0.93	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	PM20D1	0.26	0.13	enet	14	0.16	9.7e-10	5.1	6.2	5.0e-10	-0.72	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	NUCKS1	0.07	0.07	blup	59	0.07	1.3e-07	-8.0	6.2	6.1e-10	-0.90	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB7L1	0.09	0.08	enet	11	0.08	1.7e-09	7.1	-6.2	7.6e-10	0.76	0.42	0.58	FALSE
19	GTEx	Cells Transformed fibroblasts	RAB7L1	0.30	0.23	enet	19	0.36	8.6e-28	2.7	-6.0	2.5e-09	0.69	0.98	0.02	FALSE
81	The Cancer Genome Atlas	Rectum Adenocarcinoma	PM20D1	0.17	0.02	blup	47	0.01	2.2e-01	-8.0	5.9	2.8e-09	-0.79	0.00	0.76	FALSE
31	GTEx	Muscle Skeletal	RAB7L1	0.16	0.14	lasso	8	0.15	2.9e-14	4.5	-5.8	8.0e-09	0.64	0.88	0.12	FALSE
44	GTEx	Testis	RAB7L1	0.41	0.21	lasso	13	0.26	9.2e-12	4.5	-5.7	9.2e-09	0.59	0.98	0.01	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB7L1	0.02	0.02	enet	5	0.03	4.6e-04	5.2	-5.7	1.2e-08	0.69	0.02	0.56	FALSE
23	GTEx	Esophagus Mucosa	SLC41A1	0.17	0.09	enet	25	0.12	1.1e-08	-7.6	-5.5	3.8e-08	0.73	0.04	0.96	FALSE
33	GTEx	Nerve Tibial	RAB7L1	0.35	0.14	enet	68	0.22	1.8e-15	3.5	-5.5	4.8e-08	0.60	0.82	0.18	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	PM20D1	0.09	0.11	enet	6	0.10	1.3e-07	5.1	5.5	5.0e-08	-0.75	0.04	0.96	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB7L1	0.06	0.05	enet	6	0.06	2.6e-07	3.5	-5.4	5.3e-08	0.66	0.58	0.37	FALSE
5	GTEx	Adipose Subcutaneous	RAB7L1	0.20	0.09	lasso	4	0.18	7.6e-15	4.5	-5.4	7.2e-08	0.60	0.98	0.02	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB7L1	0.02	0.02	enet	5	0.02	3.1e-04	3.5	-5.3	1.4e-07	0.62	0.33	0.42	FALSE
76	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PM20D1	0.34	0.13	enet	20	0.21	9.7e-09	3.4	5.2	1.8e-07	-0.73	0.02	0.98	FALSE
47	GTEx	Whole Blood	RAB7L1	0.14	0.11	lasso	5	0.10	3.1e-09	3.7	-5.2	2.2e-07	0.52	0.77	0.23	FALSE
51	METSIM	Adipose	SLC41A1	0.07	0.08	lasso	7	0.08	1.9e-11	5.1	-5.2	2.6e-07	0.73	0.74	0.26	FALSE
50	METSIM	Adipose	RAB7L1	0.08	0.04	bslmm	401	0.05	8.6e-08	7.1	-5.2	2.7e-07	0.54	0.91	0.08	FALSE