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chr2:23,604,114-25,889,403

Best TWAS P=2.31e-14 · Best GWAS P=7.95e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-6.93	7.6	2.3e-14	-0.43	0.94	0.06	TRUE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	-4.57	7.0	3.0e-12	-0.71	0.02	0.96	TRUE
8	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-6.78	6.8	1.3e-11	-0.38	0.27	0.29	TRUE
13	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	-5.75	6.5	1.0e-10	-0.44	0.71	0.06	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-6.08	6.1	1.2e-09	-0.40	1.00	0.00	TRUE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-4.97	6.1	1.2e-09	-0.33	0.51	0.04	TRUE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCOA1	0.08	0.07	blup	77	0.05	5.8e-04	3.41	-5.5	4.0e-08	0.80	0.10	0.64	TRUE
9	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	0.94	-5.2	1.8e-07	0.18	0.01	0.03	TRUE
10	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-2.97	-5.2	2.6e-07	0.64	0.02	0.71	TRUE
15	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-6.93	-7.3	2.4e-13	0.45	0.95	0.05	FALSE
11	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-3.00	-7.2	4.1e-13	0.64	0.02	0.96	FALSE
16	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-6.65	-7.0	3.2e-12	0.42	0.96	0.04	FALSE
12	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-5.75	6.8	7.8e-12	-0.42	0.94	0.04	FALSE
5	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	-5.75	-6.7	2.4e-11	0.51	0.99	0.01	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-6.78	6.7	2.5e-11	-0.38	0.69	0.15	FALSE
14	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-6.65	-6.7	3.0e-11	0.41	0.97	0.02	FALSE
6	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	-5.75	-5.8	6.9e-09	0.47	0.81	0.12	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-6.78	-5.7	9.4e-09	0.34	0.80	0.04	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	-2.38	5.4	6.4e-08	-0.70	0.26	0.72	FALSE
4	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	5.07	-5.2	1.7e-07	0.33	0.97	0.01	FALSE