[Hub]/) : Traits : Hip circumference :

chr2:24,324,172-26,088,769

Best TWAS P=6.65e-27 · Best GWAS P=1.35e-23 conditioned to 0.806

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADCY3 0.16 0.12 lasso 10 0.14 3.2e-17 9.5 -10.7 6.6e-27 -0.87 0.01 0.99 TRUE
2 CommonMind Brain Pre-frontal Cortex CENPO 0.07 0.03 bslmm 322 0.03 7.0e-05 5.5 -6.3 3.2e-10 -0.49 0.44 0.30 FALSE
3 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 8.5 7.9 3.4e-15 0.86 0.07 0.91 FALSE
4 GTEx Adipose Subcutaneous RP11-443B20.1 0.04 0.00 enet 10 0.00 1.2e-01 4.6 6.3 2.2e-10 0.81 0.04 0.90 FALSE
5 GTEx Artery Tibial ADCY3 0.21 0.14 lasso 6 0.15 4.3e-12 7.9 8.9 4.8e-19 0.69 0.98 0.02 FALSE
6 GTEx Artery Tibial RP11-443B20.1 0.17 0.08 enet 40 0.09 8.2e-08 7.9 7.4 1.1e-13 0.59 0.40 0.56 FALSE
7 GTEx Cells EBV-transformed lymphocytes ADCY3 0.25 0.23 enet 10 0.12 9.2e-05 8.5 -7.2 7.4e-13 -0.84 0.03 0.97 FALSE
8 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 8.5 -9.0 1.9e-19 -0.93 0.01 0.97 FALSE
9 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 7.9 -9.8 8.6e-23 -0.91 0.02 0.98 FALSE
10 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 7.9 -9.7 3.1e-22 -0.81 0.04 0.95 FALSE
11 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 8.4 8.4 5.7e-17 0.80 0.93 0.07 FALSE
12 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 8.5 9.5 2.3e-21 0.86 1.00 0.00 FALSE
13 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 8.4 9.8 1.3e-22 0.86 0.80 0.20 FALSE
14 METSIM Adipose EFR3B 0.04 0.00 bslmm 357 0.00 9.7e-02 -1.5 -7.0 3.3e-12 -0.37 0.06 0.08 FALSE
15 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 8.5 -9.1 6.0e-20 -0.89 0.77 0.23 FALSE
16 YFS Blood ADCY3 0.07 0.02 bslmm 343 0.04 7.3e-14 9.8 -6.9 6.7e-12 -0.61 0.01 0.99 FALSE
17 YFS Blood POMC 0.35 0.05 enet 71 0.19 5.7e-59 -5.6 -5.6 1.8e-08 -0.31 1.00 0.00 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma POMC 0.08 0.05 lasso 3 0.06 2.6e-12 -3.0 -5.7 1.3e-08 -0.20 0.97 0.03 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POMC 0.06 0.00 enet 12 0.03 9.3e-05 -3.0 -5.5 3.2e-08 -0.27 0.01 0.41 FALSE
20 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EFR3B 0.03 0.05 lasso 1 0.04 1.9e-05 -7.4 -7.4 1.9e-13 -0.67 0.55 0.06 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 5.0 -8.1 4.1e-16 -0.87 0.04 0.92 FALSE
22 The Cancer Genome Atlas Lung Adenocarcinoma DNAJC27 0.05 0.01 blup 46 0.04 3.2e-05 2.8 -5.7 1.0e-08 -0.55 0.34 0.61 FALSE
23 The Cancer Genome Atlas Lung Adenocarcinoma POMC 0.14 0.04 enet 7 0.08 5.3e-10 -3.0 -6.5 6.2e-11 -0.22 0.38 0.62 FALSE
24 The Cancer Genome Atlas Pancreatic Adenocarcinoma POMC 0.22 0.05 blup 37 0.03 2.1e-02 -3.9 -6.3 3.0e-10 -0.12 0.01 0.29 FALSE
25 The Cancer Genome Atlas Prostate Adenocarcinoma POMC 0.11 0.08 enet 7 0.09 1.6e-09 -3.0 -6.4 1.9e-10 -0.24 0.92 0.06 FALSE
26 The Cancer Genome Atlas Stomach Adenocarcinoma POMC 0.14 0.00 blup 40 0.02 2.2e-02 -3.9 -5.4 6.5e-08 -0.14 0.01 0.18 TRUE