Best TWAS P=5.98e-12 · Best GWAS P=5.21e-08 conditioned to 0.00407
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DDX17 | 0.04 | 0.02 | lasso | 6 | 0.03 | 1.2e-04 | 4.6 | 5.3 | 9.0e-08 | -0.03 | 0.07 | 0.92 | FALSE |
2 | GTEx | Artery Aorta | DDX17 | 0.07 | 0.03 | lasso | 4 | 0.04 | 2.1e-03 | 5.0 | 5.3 | 9.0e-08 | 0.01 | 0.07 | 0.84 | FALSE |
3 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 4.8 | -5.2 | 2.6e-07 | -0.50 | 0.09 | 0.56 | FALSE |
4 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 4.6 | -5.9 | 3.2e-09 | -0.47 | 0.06 | 0.47 | TRUE |
5 | GTEx | Artery Coronary | CBY1 | 0.26 | 0.20 | lasso | 4 | 0.22 | 8.3e-08 | 4.9 | -5.2 | 2.6e-07 | 0.05 | 0.07 | 0.93 | FALSE |
6 | GTEx | Artery Tibial | RP3-508I15.9 | 0.18 | 0.21 | lasso | 8 | 0.21 | 1.3e-16 | 4.9 | -5.2 | 2.4e-07 | 0.05 | 0.07 | 0.93 | FALSE |
7 | GTEx | Brain Cortex | RP3-508I15.9 | 0.21 | 0.12 | lasso | 7 | 0.10 | 1.1e-03 | 5.0 | -5.3 | 1.1e-07 | 0.05 | 0.06 | 0.90 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | RP3-508I15.9 | 0.31 | 0.43 | lasso | 15 | 0.43 | 6.2e-35 | 5.1 | -5.2 | 2.7e-07 | 0.06 | 0.05 | 0.94 | FALSE |
9 | GTEx | Esophagus Mucosa | SUN2 | 0.12 | 0.14 | lasso | 3 | 0.14 | 1.3e-09 | 4.9 | -5.4 | 7.2e-08 | 0.04 | 0.05 | 0.95 | FALSE |
10 | GTEx | Esophagus Muscularis | RP3-508I15.9 | 0.13 | 0.12 | enet | 23 | 0.10 | 1.1e-06 | 4.9 | -5.2 | 1.7e-07 | 0.06 | 0.06 | 0.94 | FALSE |
11 | GTEx | Lung | TOMM22 | 0.05 | 0.04 | enet | 11 | 0.04 | 3.8e-04 | 4.6 | -5.3 | 8.6e-08 | -0.10 | 0.06 | 0.91 | FALSE |
12 | GTEx | Nerve Tibial | TOMM22 | 0.11 | 0.08 | lasso | 4 | 0.08 | 5.2e-06 | 5.1 | -5.8 | 7.7e-09 | 0.04 | 0.07 | 0.90 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | SUN2 | 0.13 | 0.00 | enet | 36 | 0.02 | 2.9e-02 | 5.2 | -6.9 | 6.0e-12 | -0.12 | 0.04 | 0.91 | TRUE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | RP3-508I15.19 | 0.14 | 0.06 | enet | 39 | 0.03 | 7.8e-03 | 5.2 | -6.3 | 3.2e-10 | -0.02 | 0.04 | 0.92 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | JOSD1 | 0.09 | 0.15 | lasso | 2 | 0.14 | 1.7e-11 | 5.1 | -5.1 | 2.8e-07 | 0.07 | 0.05 | 0.95 | FALSE |
16 | GTEx | Spleen | SYNGR1 | 0.36 | 0.41 | lasso | 2 | 0.36 | 3.4e-10 | 5.2 | 5.2 | 2.4e-07 | 0.02 | 0.00 | 1.00 | TRUE |
17 | GTEx | Testis | RP3-508I15.9 | 0.13 | 0.11 | lasso | 4 | 0.13 | 1.6e-06 | 4.9 | -5.3 | 1.4e-07 | 0.04 | 0.06 | 0.93 | FALSE |
18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUN2 | 0.01 | 0.00 | blup | 60 | 0.00 | 1.4e-01 | -3.1 | -5.2 | 2.5e-07 | 0.02 | 0.01 | 0.23 | FALSE |
19 | The Cancer Genome Atlas | Colon Adenocarcinoma | CBY1 | 0.07 | 0.11 | enet | 18 | 0.10 | 1.2e-06 | 5.0 | 5.1 | 3.1e-07 | -0.07 | 0.02 | 0.97 | FALSE |
20 | The Cancer Genome Atlas | Colon Adenocarcinoma | JOSD1 | 0.05 | 0.02 | blup | 50 | 0.04 | 2.7e-03 | 4.8 | -5.3 | 1.4e-07 | 0.06 | 0.04 | 0.80 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | JOSD1 | 0.08 | 0.03 | enet | 5 | 0.04 | 3.4e-05 | 4.3 | -5.1 | 3.0e-07 | 0.06 | 0.06 | 0.92 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC646851 | 0.02 | 0.03 | lasso | 1 | 0.02 | 1.2e-03 | 5.2 | 5.2 | 2.6e-07 | -0.07 | 0.02 | 0.81 | FALSE |
23 | The Cancer Genome Atlas | Lung Adenocarcinoma | TOMM22 | 0.02 | 0.02 | blup | 43 | 0.02 | 1.7e-03 | 5.1 | -5.2 | 2.1e-07 | 0.06 | 0.02 | 0.86 | FALSE |
24 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LOC646851 | 0.08 | 0.06 | blup | 47 | 0.07 | 8.1e-04 | 4.6 | 5.2 | 2.3e-07 | -0.06 | 0.03 | 0.91 | FALSE |
25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC646851 | 0.03 | 0.03 | blup | 48 | 0.03 | 2.7e-04 | 4.6 | 5.2 | 2.4e-07 | -0.07 | 0.03 | 0.93 | FALSE |
26 | The Cancer Genome Atlas | Thyroid Carcinoma | PDGFB | 0.08 | 0.01 | blup | 59 | 0.03 | 1.1e-03 | 4.9 | -5.2 | 2.2e-07 | -0.03 | 0.00 | 0.52 | TRUE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | TOMM22 | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.1e-04 | 5.1 | -5.4 | 5.6e-08 | 0.04 | 0.02 | 0.97 | FALSE |