TWAS hub - PDGFB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.110	0.046	0.0068	-0.002	NA	0.014	NA	0.003	0.470	NA	0.0220	NA	0.180
2	TCGA	Thyroid Carcinoma	0.079	0.038	0.0027	0.011	0.027	0.019	NA	0.006	0.028	0.0011	0.0051	NA	0.082

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse wave peak to peak time	5.2	6.2	6.2	2.5	-2.5
Rheumatoid Arthritis	4.9	6.7	8.9	2.1	-3.0
Pulse wave Arterial Stiffness index	4.6	5.4	5.7	-2.4	2.3
Blood clot in the leg (DVT)	4.4	5.7	11.2	0.5	3.3
Pulse rate, automated reading	4.2	13.7	27.4	-5.2	0.1
Primary Biliary Cirrhosis	4.0	5.8	9.9	1.3	-3.1
Deep venous thrombosis (DVT) (self-reported)	4.0	5.2	10.0	0.6	3.2
Crohns Disease (2012)	3.9	6.2	6.9	2.4	2.6
Irritable Bowel Disease (IBD)	3.7	8.8	11.3	2.5	3.4
Basal cell carcinoma (self-reported)	3.7	4.4	5.5	-1.8	2.4
Crohns Disease (2017)	3.3	7.3	10.7	2.0	3.3
Hip circumference	3.3	14.0	26.8	1.1	-5.2
Illness, injury, bereavement, stress in last 2 years	3.3	4.0	5.5	-1.6	2.3
Financial difficulties in last 2 years	3.2	4.3	6.0	1.6	-2.4
Severe depression (siblings)	3.1	3.4	6.7	-0.5	2.6
High cholesterol (Self-reported)	3.0	5.4	10.8	0.1	3.3
Pain all over the body in last month	2.9	3.1	6.1	-0.3	2.5
Pulse rate	2.8	4.7	7.7	-2.8	1.3
Taking other prescription medications	2.7	4.2	8.3	-2.9	-0.1
Reaction Time	2.6	5.0	9.2	3.0	0.9
Stomach or abdominal pain in last month	2.6	3.2	6.3	-0.2	2.5
Alcohol drinker status: Never	2.6	3.1	5.8	-0.6	-2.4
Hearing aid user	2.4	2.7	5.2	-2.3	0.3
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	5.6	0.2	2.4
Medication: Ramipril	2.3	3.0	4.1	2.0	1.4
Weight	2.3	11.3	22.5	0.3	-4.7
Number of children fathered	2.3	2.6	2.7	-1.6	-1.6
Eye problems/disorders: None of the above	2.2	2.6	3.7	-1.9	-1.2
Wears glasses or contact lenses	2.2	2.5	4.8	-2.2	0.4
Myopia	2.2	3.2	4.8	-2.2	1.2
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.1	2.0	-1.0
Trunk fat mass	2.1	8.9	17.8	0.2	-4.2
Ever used hormone-replacement therapy (HRT)	2.0	2.5	3.1	-1.4	1.8
Medication: Seretide 50 evohaler	2.0	2.3	4.0	-2.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	5.9	0.6	2.4
Ever had prostate specific antigen (PSA) test	2.0	2.3	2.7	-1.6	1.4
Schizophrenia (2014)	1.9	4.2	8.1	2.8	-0.5
Birth weight of first child	1.9	3.4	5.0	2.2	1.3
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	6.5	0.9	-2.6
Chronotype (morning person)	1.8	4.2	7.4	2.7	1.0
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.3	1.8	-1.0
Whole body fat mass	1.8	7.7	15.4	-0.0	-3.9
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.9	-0.6	-2.0
Hypothyroidism (self reported)	1.7	4.0	7.7	0.4	-2.8
Diabetes (father)	1.7	2.1	3.8	-1.9	0.7
Trunk fat percentage	1.7	6.7	13.4	0.1	-3.7
Age when periods started (menarche)	1.7	4.2	5.4	2.3	-1.7
Prospective memory result	1.7	2.1	3.7	1.9	-0.7
Arm fat mass (right)	1.7	6.9	13.8	0.1	-3.7
Worry too long after embarrassment	1.7	2.8	5.1	-2.2	0.7
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.4	-1.8	0.8
Cardiovascular Disease	1.6	5.4	6.9	2.6	2.0
Waist circumference	1.6	5.8	11.5	-0.4	-3.4
Length of working week for main job	1.6	1.8	3.6	1.9	-0.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.2	-1.8	0.7
Leg fat mass (right)	1.6	6.1	12.0	-0.5	-3.5
Leg fat-free mass (right)	1.6	8.6	16.6	0.7	-4.1
Leg predicted mass (right)	1.6	8.5	16.5	0.7	-4.1
Basal metabolic rate	1.6	9.0	17.6	0.6	-4.2
Ever depressed for a whole week	1.6	2.0	2.5	-1.6	1.3
Leg fat mass (left)	1.6	6.2	12.2	-0.5	-3.5
Alzheimer’s Disease (in father)	1.5	1.6	2.4	-0.9	-1.5
Ulcerative Colitis (UC)	1.5	2.9	3.7	1.4	1.9
Ulcerative Colitis	1.5	2.2	3.7	0.8	1.9
Leg fat-free mass (left)	1.5	8.1	15.5	0.9	-3.9
Leg predicted mass (left)	1.5	8.0	15.3	0.8	-3.9
Allergy	1.5	3.6	4.3	2.1	-1.7
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.6	-0.3	1.9
Mean time to correctly identify matches	1.5	2.9	4.6	2.2	1.1
Handedness (chirality/laterality): Left-handed	1.5	1.7	3.2	-0.6	-1.8
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.3	0.8	-1.8
Age started oral contraceptive pill	1.5	1.9	1.9	-1.4	-1.4
Alcohol drinker status: Previous	1.5	1.7	3.3	1.8	0.2
BMI	1.4	8.3	16.6	0.1	-4.1
Hayfever, allergic rhinitis or eczema	1.4	2.9	4.4	-2.1	1.2
Heart attack	1.4	1.8	3.6	-0.2	1.9
Medication: Simvastatin	1.4	2.0	2.8	1.1	1.7
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	7.5	2.7	-1.5
Breastfed as a baby	1.4	1.7	2.8	0.7	-1.7
Medication: Amlodipine	1.4	2.0	4.0	-0.2	2.0
Whole body fat-free mass	1.4	8.1	15.8	0.6	-4.0
Qualifications: nursing, teaching	1.4	2.2	2.3	1.5	-1.5
Arm fat mass (left)	1.4	5.8	11.7	0.1	-3.4
Bipolar Disorder (2018)	1.3	2.1	2.2	1.4	-1.5
Bipolar Disorder or Schizophrenia	1.3	3.1	4.8	2.2	-1.2
Alcohol intake versus 10 years previously	1.3	1.9	3.8	0.2	1.9
Qualifications: A levels/AS levels or equivalent	1.3	2.9	3.9	-1.4	2.0
Standing height	1.3	12.9	20.0	2.4	-4.5
Medication: Ventolin 100micrograms inhaler	1.3	1.7	1.9	-1.2	-1.4
Body fat percentage	1.3	5.3	10.5	-0.0	-3.2
Neck or shoulder pain in last month	1.3	1.8	2.8	-0.9	-1.7
Illnesses of father: Heart disease	1.3	1.8	1.9	-1.3	1.4
Osteoarthritis (self-reported)	1.3	1.6	2.0	-1.4	-1.1
Whole body water mass	1.3	7.7	15.1	0.5	-3.9
Average weekly champagne plus white wine intake	1.3	1.8	2.5	-1.6	1.0
Arm fat-free mass (left)	1.3	6.5	13.0	-0.1	-3.6
Fractured/broken bones in last 5 years	1.3	1.6	1.8	1.4	-1.2
Cholesterol lowering medication	1.3	1.9	3.8	0.2	2.0
Age at First Birth	1.2	1.7	2.6	0.9	-1.6
Sensitivity / hurt feelings	1.2	2.1	4.1	-2.0	0.3
Serious illness, injury or assault to yourself	1.2	1.5	2.8	1.7	-0.4
Arm fat percentage (right)	1.2	4.9	9.7	0.3	-3.1
Trunk fat-free mass	1.2	6.7	13.0	0.7	-3.6
Trunk predicted mass	1.2	6.6	12.6	0.7	-3.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.2	-1.5	1.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.1	1.8	-0.3
Shortness of breath walking on level ground	1.2	1.4	2.1	-1.4	-0.9
Heart disease (mother)	1.2	1.4	1.5	1.2	1.2
Comparative height size at age 10	1.2	6.8	12.4	1.1	-3.5
Arm fat percentage (left)	1.2	4.7	9.4	0.3	-3.1
Mineral and other dietary supplements	1.2	1.6	3.1	0.2	1.8
Medication: Blood pressure	1.2	2.3	4.1	2.0	0.6
Medication: Bendroflumethiazide	1.2	1.9	3.3	1.8	-0.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.9	-0.4	1.7
Arm predicted mass (left)	1.2	5.9	11.7	-0.2	-3.4
Prostate Cancer	1.1	1.5	2.5	-1.6	0.7
Waist Hip Ratio (WHR)	1.1	5.1	7.5	-1.6	2.7
Body mass index (BMI)	1.1	4.8	8.9	-0.8	-3.0
Forced vital capacity (FVC)	1.1	4.2	7.0	2.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.6	-0.5	1.6
Alcohol intake frequency.	1.1	2.6	4.8	2.2	-0.7
Guilty feelings	1.1	1.6	3.2	-1.8	0.2
Vascular/heart problems diagnosed by doctor	1.1	3.0	4.3	-2.1	-1.2
Schizophrenia (2018)	1.0	2.0	3.8	2.0	-0.4
Body Mass Index (BMI) (2010)	1.0	1.4	2.7	0.4	-1.6
Diabetes (mother)	1.0	1.2	1.6	1.3	0.9
Mouth/teeth dental problems	1.0	1.6	3.0	-1.7	0.4
Depression (self-reported)	1.0	1.2	2.4	-1.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	4.6	2.2	-1.3
Tense / ‘highly strung’	1.0	1.6	1.8	-1.2	1.4
Arm predicted mass (right)	1.0	4.9	9.9	-0.1	-3.1
Had major operations	1.0	1.2	1.6	1.3	0.9
Knee pain experienced in last month	1.0	1.6	3.1	1.8	-0.2
Medication for cholesterol	1.0	1.6	2.7	-0.6	-1.7
Triglycerides	0.9	1.4	1.8	1.3	-1.1
Heel T-Score	0.9	7.3	14.2	-3.8	0.6
Allergy or Eczema	0.9	2.4	4.3	-2.1	0.8
Maternal smoking around birth	0.9	1.4	2.6	0.4	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.6	1.3	-0.9
Past tobacco smoking	0.9	1.7	3.5	1.9	0.1
Diabetes (self-reported)	0.9	1.3	2.2	-1.5	0.7
High blood pressure (siblings)	0.9	1.2	2.4	-1.6	0.1
Arm fat-free mass (right)	0.9	4.8	9.6	0.0	-3.1
Medication: Omeprazole	0.9	1.0	1.9	-0.5	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.1	0.4	-1.4
Financial situation satisfaction	0.9	1.1	1.2	1.0	-1.1
Alzheimer’s Disease (including proxy)	0.8	1.2	1.9	-0.7	-1.4
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.5	-1.9	-0.5
Height	0.8	15.1	24.8	2.3	-5.0
Hair Pigment	0.8	22.5	44.5	-0.7	6.7
Townsend deprivation index at recruitment	0.8	1.2	1.8	1.3	0.8
Hair/balding pattern: Pattern 2	0.8	1.1	1.1	1.0	1.0
Asthma	0.8	1.6	3.3	-1.8	0.1
Medication: Lansoprazole	0.8	0.9	1.9	1.4	0.0
Lung cancer (father)	0.8	0.9	1.8	1.4	-0.0
Peak expiratory flow (PEF)	0.8	1.9	2.8	1.0	-1.7
Glaucoma (self-reported)	0.8	0.9	1.8	-0.3	1.3
Migraine (self-reported)	0.8	1.0	1.3	0.8	1.2
Chest pain or discomfort	0.8	1.2	1.8	0.8	1.3
Illnesses of siblings: Diabetes	0.8	1.0	2.0	-1.4	0.2
Smoking status: Previous	0.8	1.2	2.5	-1.6	-0.0
Medication: Gliclazide	0.8	0.9	1.5	-1.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.0	1.2	-1.4
Ever taken oral contraceptive pill	0.8	0.9	1.0	-0.9	1.0
Medication: Atorvastatin	0.8	1.0	1.9	0.0	1.4
Leg fat percentage (left)	0.8	3.0	5.6	-0.7	-2.4
Supplements: Calcium	0.8	0.8	1.6	-1.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.2	-1.5	0.7
Medication: Co-codamol	0.7	0.8	1.3	-0.5	1.1
Qualifications: CSEs or equivalent	0.7	1.0	1.9	1.4	-0.3
Multivitamins +/- minerals	0.7	0.9	1.5	0.6	-1.2
Time employed in main current job	0.7	0.8	1.6	0.0	-1.2
Medication: Cholesterol lowering	0.7	1.1	2.1	-0.2	1.4
Leg fat percentage (right)	0.7	2.4	4.6	-0.4	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.7	-1.3	0.3
Family relationship satisfaction	0.7	0.9	1.6	0.4	1.3
Average weekly red wine intake	0.7	1.0	1.9	1.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	-1.3	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.8	1.3	-0.1
Commuting to job workplace: Public transport	0.7	0.9	1.6	-0.2	1.3
Diastolic blood pressure, automated reading	0.7	2.2	3.9	-2.0	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.7	1.8	-1.3	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	0.8	0.9	-0.8
Major Depression (MDD)	0.6	0.7	1.1	1.0	-0.5
HDL Cholesterol	0.6	1.0	1.2	1.1	0.9
Angina	0.6	0.8	1.3	0.5	1.1
Impedance of leg (right)	0.6	2.7	4.3	1.0	2.1
Relative age voice broke	0.6	0.9	1.7	-1.3	-0.1
High blood pressure	0.6	1.8	3.2	1.8	0.6
Fluid intelligence score	0.6	1.3	2.3	-1.5	-0.6
Impedance of arm (left)	0.6	2.6	5.0	2.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	1.2	1.1	-1.1
Diabetes diagnosed by doctor	0.6	0.9	1.5	-1.2	0.6
Illnesses of father: High blood pressure	0.6	0.7	1.2	1.1	0.5
Irritability	0.6	0.9	1.8	-1.3	-0.3
Risk taking	0.6	0.9	1.7	0.0	1.3
Ovarian Cancer	0.5	0.7	1.4	0.2	-1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.2	-1.1	0.0
Fasting Glucose	0.5	0.6	1.2	-1.1	0.0
Blood Eosinophil Count	0.5	3.8	4.0	1.9	-2.0
Lung FEV1/FVC ratio	0.5	2.6	4.9	2.2	-0.5
Hearing difficulty/problems: Yes	0.5	0.8	0.8	-0.9	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.6	-0.8	0.7
Vitamin and mineral supplements	0.5	0.7	1.2	-0.3	1.1
Medication: Metformin	0.5	0.7	1.4	-1.2	0.1
Sitting height	0.5	3.2	6.2	0.5	-2.5
High blood pressure (mother)	0.5	0.7	0.8	-0.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.2	-0.2	1.1
Impedance of arm (right)	0.5	2.4	4.9	2.2	0.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.2	-1.1	-0.6
Illnesses of mother	0.5	0.6	0.9	-0.6	-0.9
Loud music exposure frequency	0.5	0.6	0.9	1.0	-0.5
Gout (self-reported)	0.5	0.6	1.1	-0.4	1.0
Forced vital capacity (FVC), Best measure	0.5	1.9	3.4	1.8	-0.6
Emphysema/chronic bronchitis	0.5	0.5	0.6	-0.7	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.5	0.3	1.2
Angina (self-reported)	0.5	0.7	1.2	0.3	1.1
Suffer from ‘nerves’	0.5	0.8	1.6	1.3	0.2
Hypertension (Self-reported)	0.5	1.5	2.4	1.6	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.5	1.0
Ever had bowel cancer screening	0.5	0.6	1.0	-1.0	0.3
Asthma (self-reported)	0.5	0.9	1.8	-1.3	0.1
Medication: Paracetamol	0.5	0.8	1.4	0.5	1.2
Ever smoked	0.5	0.8	1.6	-1.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	0.3	1.0
Impedance of whole body	0.5	2.4	3.2	1.8	1.3
HbA1C	0.4	0.4	0.6	-0.7	-0.5
Blood Platelet Count	0.4	4.8	5.2	2.3	-2.1
Smoking Status	0.4	1.0	1.9	-1.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-1.0	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.6	-1.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.6	0.5	-0.8
Medication: Levothyroxine sodium	0.4	0.7	1.3	0.2	-1.1
Impedance of leg (left)	0.4	1.7	3.2	0.5	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.9	1.0	-0.5
Noisy workplace	0.4	0.5	0.5	-0.7	0.7
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	-0.3	-1.1
Exposure to tobacco smoke outside home	0.4	0.6	1.1	0.2	1.0
Number of full sisters	0.4	0.4	0.9	-0.9	-0.0
Age at last live birth	0.4	0.6	1.0	-0.5	1.0
Osteoporosis (self-reported)	0.4	0.6	0.8	0.9	0.6
Heart disease (siblings)	0.4	0.5	0.9	-0.9	-0.1
Pack years of smoking	0.4	0.5	1.0	-0.1	-1.0
Lupus	0.3	0.5	1.0	1.0	-0.0
Blood Red Count	0.3	3.4	6.2	0.8	2.5
Blood White Count	0.3	2.2	3.6	1.9	0.9
Systolic Blood Pressure	0.3	1.4	2.5	1.6	0.6
Neuroticism	0.3	0.8	1.4	-1.2	-0.3
Average weekly spirits intake	0.3	0.4	0.6	-0.4	-0.8
Pack years adult smoking proportion	0.3	0.5	1.0	0.3	-1.0
Average weekly fortified wine intake	0.3	0.4	0.6	0.4	0.8
Number of incorrect matches in round	0.3	0.6	1.0	1.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.9	0.3
Had menopause	0.3	0.4	0.7	-0.1	-0.8
Qualifications: None of the above	0.3	0.7	1.2	0.5	1.1
Illnesses of siblings	0.3	0.4	0.7	0.8	-0.2
Neuroticism score	0.3	0.7	1.4	-1.2	0.2
Father’s age at death	0.3	0.4	0.5	-0.7	-0.5
Exposure to tobacco smoke at home	0.3	0.3	0.4	-0.5	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	0.9	0.9	0.9
Headache pain in last month	0.3	0.6	1.0	0.5	1.0
Medication: Allopurinol	0.3	0.4	0.5	0.6	-0.7
Friendships satisfaction	0.3	0.4	0.8	-0.9	0.0
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	0.6	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.5	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	-0.4
Depression (Nagel 2018)	0.2	0.4	0.7	-0.0	-0.9
LDL Cholesterol	0.2	0.3	0.4	-0.5	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.1	0.7
Number of treatments/medications taken	0.2	0.3	0.6	-0.1	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	-0.7	-0.1
Supplements: Zinc	0.2	0.2	0.2	-0.3	-0.5
Medication: Atenolol	0.2	0.3	0.4	0.4	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.1	0.7
Alcohol usually taken with meals	0.2	0.4	0.4	-0.6	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	-0.2	-0.9
Number of live births	0.2	0.3	0.4	0.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.1	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.3	-0.6	0.5
Age at first live birth	0.2	0.3	0.5	-0.7	0.3
Health satisfaction	0.2	0.2	0.4	-0.6	-0.1
Supplements: Vitamin C	0.2	0.3	0.4	0.6	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	0.4	0.4
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.6	0.0
Miserableness	0.2	0.4	0.6	-0.8	0.4
Pain experienced in last month	0.2	0.4	0.8	0.1	-0.9
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.8	-0.1
Mean Putamen Volume	0.1	0.2	0.2	-0.4	0.4
Neuroticism (2016)	0.1	0.1	0.3	0.1	-0.5
Respiratory disease	0.1	0.2	0.4	-0.3	-0.6
Lung FVC	0.1	0.3	0.6	-0.1	0.8
Tanning	0.1	1.1	2.2	-0.3	-1.5
Hand grip strength (left)	0.1	0.2	0.4	0.6	0.3
Relative age of first facial hair	0.1	0.2	0.3	-0.5	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	0.3
Systolic blood pressure, automated reading	0.1	0.2	0.2	0.4	-0.5
Fed-up feelings	0.1	0.2	0.3	0.2	0.6
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	-0.4
Nervous feelings	0.1	0.1	0.2	0.4	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.6	0.2
Worrier / anxious feelings	0.1	0.1	0.1	0.3	0.4
Happiness	0.1	0.2	0.3	0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.0	-0.6
Pulse wave reflection index	0.1	0.1	0.2	-0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.0	0.4
Medication: Paracetamol	0.1	0.1	0.3	-0.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.2	-0.6
Birth weight	0.1	0.3	0.4	0.5	-0.6
Comparative body size at age 10	0.1	0.3	0.5	0.2	-0.7
Qualifications: College or University degree	0.1	0.4	0.4	-0.6	0.6
Medication: Ibuprofen	0.1	0.1	0.2	0.5	-0.2
Leg pain on walking	0.1	0.1	0.1	0.4	0.2
Medication: Aspirin	0.1	0.1	0.1	-0.3	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.2	0.5	0.5
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.4	0.2
Back pain experienced in last month	0.1	0.2	0.3	0.4	-0.5
Breast cancer (self-reported)	0.1	0.1	0.1	0.1	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.1	0.6
Mother’s age at death	0.1	0.1	0.1	-0.3	0.3
Number of operations (self-reported)	0.1	0.2	0.4	0.6	0.1
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.1	-0.6
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.4	0.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.0	-0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.2	-0.2
Worry (Nagel 2018)	0.0	0.1	0.1	0.1	0.3
Breast Cancer	0.0	0.0	0.0	-0.2	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	-0.0
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	-0.1
Hand grip strength (right)	0.0	0.1	0.1	0.4	-0.3
Current tobacco smoking	0.0	0.0	0.0	0.2	-0.1
Had other major operations	0.0	0.0	0.1	0.3	-0.2
Falls in the last year	0.0	0.0	0.0	0.2	-0.2
Number of full brothers	0.0	0.0	0.0	0.2	0.2
Medication: Blood pressure	0.0	0.1	0.1	-0.3	-0.1
Overall health rating	0.0	0.1	0.2	0.4	-0.0
Mood swings	0.0	0.1	0.1	-0.1	0.4
Loneliness, isolation	0.0	0.0	0.1	-0.3	0.0
Medication: Aspirin	0.0	0.0	0.0	0.1	0.1
Smoking status: Current	0.0	0.1	0.1	0.1	-0.4
Medication: Lisinopril	0.0	0.0	0.0	-0.0	-0.2

Hub : Genes

PDGFB

Models

Trait associations