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chr1:45,100,098-48,543,158

Best TWAS P=4.03e-13 · Best GWAS P=1.65e-12 conditioned to 0.235

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CYP4X1	0.04	0.00	blup	405	0.04	3.4e-05	-4.1	5.2	2.6e-07	-0.02	0.10	0.17	FALSE
2	GTEx	Adipose Subcutaneous	MUTYH	0.04	0.00	enet	23	0.00	8.5e-01	3.8	-5.1	2.9e-07	-0.63	0.08	0.57	FALSE
3	GTEx	Adipose Subcutaneous	GPBP1L1	0.05	0.05	lasso	4	0.05	8.7e-05	-5.1	-6.6	5.3e-11	-0.77	0.17	0.81	FALSE
4	GTEx	Adipose Subcutaneous	RP11-767N6.2	0.03	0.03	enet	6	0.04	3.0e-04	4.4	5.8	8.3e-09	0.77	0.10	0.73	FALSE
5	GTEx	Adipose Visceral Omentum	PIK3R3	0.07	0.02	lasso	3	0.04	4.6e-03	6.6	6.6	3.2e-11	0.88	0.14	0.73	FALSE
6	GTEx	Adipose Visceral Omentum	GPBP1L1	0.10	0.04	lasso	6	0.06	3.4e-04	-5.2	-6.7	2.3e-11	-0.84	0.17	0.83	FALSE
7	GTEx	Adipose Visceral Omentum	CMPK1	0.11	0.12	lasso	2	0.10	4.6e-06	5.6	6.1	1.2e-09	0.01	0.02	0.98	FALSE
8	GTEx	Artery Aorta	MAST2	0.26	0.32	lasso	16	0.31	2.0e-17	-5.2	-5.2	1.9e-07	-0.55	1.00	0.00	FALSE
9	GTEx	Artery Tibial	GPBP1L1	0.04	0.04	enet	7	0.03	2.2e-03	5.2	-6.4	1.2e-10	-0.77	0.20	0.75	FALSE
10	GTEx	Artery Tibial	RP11-767N6.2	0.04	0.02	enet	5	0.04	6.9e-04	2.0	5.5	4.9e-08	0.81	0.08	0.86	FALSE
11	GTEx	Breast Mammary Tissue	GPBP1L1	0.06	0.02	lasso	5	0.00	2.4e-01	6.6	-6.8	1.2e-11	-0.91	0.10	0.65	FALSE
12	GTEx	Cells Transformed fibroblasts	MAST2	0.25	0.33	enet	16	0.30	1.0e-22	-5.1	-5.3	9.8e-08	-0.52	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	MUTYH	0.20	0.10	enet	22	0.11	8.3e-09	4.3	-6.5	1.0e-10	-0.56	0.88	0.12	FALSE
14	GTEx	Cells Transformed fibroblasts	GPBP1L1	0.05	0.02	enet	21	0.02	1.1e-02	-5.2	-6.3	3.0e-10	-0.71	0.18	0.67	FALSE
15	GTEx	Cells Transformed fibroblasts	IPP	0.04	0.08	lasso	1	0.08	2.3e-06	7.0	-7.0	2.5e-12	-0.99	0.04	0.95	FALSE
16	GTEx	Colon Sigmoid	MAST2	0.18	0.10	lasso	4	0.13	2.5e-05	-5.1	-5.5	2.9e-08	-0.61	0.66	0.28	FALSE
17	GTEx	Colon Transverse	GPBP1L1	0.06	0.01	lasso	6	0.01	8.3e-02	7.0	-6.8	8.8e-12	-0.88	0.08	0.78	FALSE
18	GTEx	Esophagus Mucosa	GPBP1L1	0.04	0.02	lasso	3	0.02	1.5e-02	7.0	-7.1	9.5e-13	-0.97	0.06	0.77	FALSE
19	GTEx	Esophagus Muscularis	CCDC17	0.04	0.04	lasso	6	0.01	9.1e-02	7.0	-7.0	3.6e-12	-0.99	0.05	0.90	FALSE
20	GTEx	Heart Atrial Appendage	MMACHC	0.10	0.06	enet	11	0.10	3.3e-05	6.5	5.2	1.5e-07	0.84	0.21	0.69	FALSE
21	GTEx	Lung	GPBP1L1	0.04	0.02	enet	14	0.02	5.8e-03	7.1	-7.2	4.1e-13	-0.89	0.07	0.89	TRUE
22	GTEx	Lung	RP11-767N6.2	0.04	0.02	enet	7	0.03	3.1e-03	6.6	5.7	1.5e-08	0.92	0.05	0.90	FALSE
23	GTEx	Muscle Skeletal	GPBP1L1	0.03	0.02	enet	19	0.03	7.2e-04	6.6	-6.0	2.1e-09	-0.85	0.08	0.87	FALSE
24	GTEx	Muscle Skeletal	RP11-767N6.7	0.06	0.06	lasso	3	0.04	6.6e-05	-5.7	-6.0	2.4e-09	-0.60	0.32	0.60	FALSE
25	GTEx	Nerve Tibial	TESK2	0.07	0.00	lasso	13	0.00	3.5e-01	3.8	5.3	8.8e-08	0.52	0.21	0.44	FALSE
26	GTEx	Nerve Tibial	IPP	0.07	0.04	enet	12	0.05	1.9e-04	-5.8	-5.5	3.2e-08	-0.67	0.52	0.25	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	CCDC17	0.10	0.13	lasso	6	0.13	9.6e-08	7.1	-7.1	1.2e-12	-0.99	0.04	0.96	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	GPBP1L1	0.09	0.02	enet	11	0.02	3.5e-02	6.9	-6.3	3.8e-10	-0.94	0.06	0.93	FALSE
29	GTEx	Skin Sun Exposed Lower leg	GPBP1L1	0.03	0.00	lasso	5	0.00	4.8e-01	4.2	-7.1	1.2e-12	-0.77	0.07	0.56	FALSE
30	GTEx	Stomach	MUTYH	0.08	0.02	lasso	4	0.02	4.1e-02	3.8	-5.7	1.4e-08	-0.73	0.07	0.58	FALSE
31	GTEx	Stomach	RP11-767N6.7	0.08	0.03	enet	16	0.05	1.3e-03	-5.2	-6.4	1.7e-10	-0.68	0.28	0.29	FALSE
32	GTEx	Testis	PIK3R3	0.08	0.05	enet	7	0.06	1.5e-03	7.1	-6.9	5.3e-12	-0.99	0.07	0.87	FALSE
33	GTEx	Testis	GPBP1L1	0.07	0.06	enet	7	0.03	1.7e-02	-5.8	-6.6	3.2e-11	-0.73	0.12	0.72	FALSE
34	GTEx	Testis	IPP	0.05	0.06	enet	8	0.03	1.4e-02	7.0	6.8	7.9e-12	0.97	0.06	0.83	FALSE
35	GTEx	Testis	RP11-767N6.2	0.05	0.00	enet	14	0.01	1.1e-01	7.0	5.8	6.1e-09	0.86	0.08	0.70	FALSE
36	GTEx	Thyroid	MAST2	0.06	0.05	lasso	4	0.04	4.9e-04	6.7	-6.8	1.1e-11	-0.85	0.20	0.76	FALSE
37	GTEx	Thyroid	CCDC17	0.05	0.08	lasso	2	0.08	1.1e-06	5.4	-5.3	9.1e-08	-0.69	0.29	0.61	FALSE
38	GTEx	Thyroid	GPBP1L1	0.05	0.06	enet	6	0.07	7.9e-06	5.2	-6.7	2.7e-11	-0.85	0.14	0.86	FALSE
39	GTEx	Thyroid	IPP	0.08	0.07	lasso	3	0.08	7.1e-07	-5.2	-5.3	1.4e-07	-0.57	0.97	0.02	FALSE
40	GTEx	Whole Blood	MAST2	0.03	0.02	lasso	3	0.02	2.9e-03	6.5	-5.8	9.1e-09	-0.89	0.10	0.79	FALSE
41	METSIM	Adipose	CCDC17	0.03	0.02	blup	287	0.01	5.6e-03	-5.2	-5.7	1.5e-08	-0.69	0.30	0.30	FALSE
42	METSIM	Adipose	MAST2	0.06	0.06	lasso	6	0.05	1.3e-08	-5.1	-5.5	3.2e-08	-0.60	0.98	0.02	FALSE
43	NTR	Blood	PIK3R3	0.01	0.02	lasso	2	0.02	4.5e-06	-5.1	-5.2	2.6e-07	-0.54	0.96	0.02	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	MMACHC	0.04	0.01	blup	274	0.02	1.4e-03	-3.8	5.5	2.9e-08	0.52	0.65	0.09	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	IPP	0.08	0.15	lasso	9	0.14	5.0e-18	6.9	-6.9	5.4e-12	-0.98	0.04	0.96	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	RPS15AP10	0.03	0.05	blup	283	0.04	8.0e-06	6.5	6.1	1.4e-09	0.95	0.06	0.94	FALSE
47	YFS	Blood	CCDC17	0.04	0.02	lasso	8	0.02	6.8e-08	6.9	-7.1	1.5e-12	-0.95	0.05	0.95	FALSE
48	YFS	Blood	IPP	0.10	0.11	lasso	15	0.12	4.6e-36	6.6	-6.4	1.7e-10	-0.95	0.15	0.85	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	CMPK1	0.02	0.01	enet	7	0.01	2.5e-03	5.4	-5.8	8.4e-09	-0.01	0.01	0.89	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPBP1L1	0.01	0.02	lasso	2	0.02	1.2e-04	7.0	-7.0	2.2e-12	-0.99	0.03	0.94	FALSE
51	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GPBP1L1	0.05	0.05	blup	51	0.06	1.0e-03	6.9	-6.4	1.7e-10	-0.98	0.03	0.81	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPBP1L1	0.03	0.04	lasso	1	0.03	8.0e-05	7.0	-7.0	2.5e-12	-0.99	0.03	0.94	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GPBP1L1	0.07	0.10	lasso	3	0.09	6.3e-06	7.0	-7.0	2.3e-12	-0.99	0.03	0.96	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MGC12982	0.07	0.02	blup	47	0.03	9.7e-03	5.9	-7.2	5.0e-13	-0.01	0.01	0.71	TRUE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPBP1L1	0.04	0.04	blup	50	0.04	2.9e-05	7.0	-7.1	9.5e-13	-0.98	0.03	0.96	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMACHC	0.07	0.05	enet	12	0.09	3.1e-09	-3.8	5.3	9.1e-08	0.47	0.37	0.62	FALSE
57	The Cancer Genome Atlas	Stomach Adenocarcinoma	IPP	0.04	0.04	blup	47	0.04	1.4e-03	6.6	-6.9	3.9e-12	-0.95	0.02	0.80	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM69	0.10	0.05	lasso	2	0.04	5.9e-04	-6.0	-6.0	2.2e-09	-0.59	0.20	0.23	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	CMPK1	0.06	0.03	blup	47	0.06	4.1e-06	4.8	-5.4	5.5e-08	-0.02	0.18	0.75	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	GPBP1L1	0.11	0.06	lasso	3	0.06	1.6e-06	7.0	-7.2	4.0e-13	-0.98	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	MAST2	0.04	0.01	blup	97	0.02	1.8e-03	6.6	-5.2	2.1e-07	-0.74	0.04	0.72	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	PIK3R3	0.05	0.01	blup	64	0.04	4.4e-05	5.1	-5.7	9.2e-09	-0.76	0.02	0.93	FALSE