Hub : Genes

CYP4X1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.037 0.0160 2.0e-03 0.004 0.035 0.012 0.034 0.005 8.5e-02 3.4e-05 1.1e-02 4.6e-05 7.4e-02
2 GTEx Adipose Subcutaneous 0.085 0.0290 2.1e-04 0.040 NA 0.059 NA 0.050 3.3e-04 NA 1.5e-05 NA 5.8e-05
3 GTEx Esophagus Mucosa 0.139 0.0530 1.3e-03 0.086 NA 0.052 NA 0.079 2.3e-06 NA 2.2e-04 NA 5.6e-06
4 GTEx Skin Sun Exposed Lower leg 0.132 0.0420 3.6e-05 0.022 NA 0.048 NA 0.044 5.7e-03 NA 7.9e-05 NA 1.5e-04
5 GTEx Testis 0.203 0.0700 3.2e-05 0.104 NA 0.081 NA 0.096 2.4e-05 NA 1.9e-04 NA 5.0e-05
6 GTEx Thyroid 0.079 0.0320 1.5e-03 0.060 NA 0.030 NA 0.057 2.3e-05 NA 2.3e-03 NA 3.7e-05
7 ROSMAP Brain Pre-frontal Cortex 0.054 0.0232 4.3e-04 0.012 0.028 0.001 0.025 0.006 8.6e-03 1.5e-04 2.0e-01 2.8e-04 5.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 0.6 -0.5 0.5 -0.5 0.3 0.8 0.5 0.3
Bipolar Disorder or Schizophrenia 0.8 2.0 4.8 -0.3 0.7 -2.2 -0.7 1.4 2.1 1.1
Depressed Affect (Nagel 2018) 1.0 2.2 4.1 0.7 -0.4 2.0 1.9 -1.5 -1.9 -0.9
Depression (Nagel 2018) 0.4 0.7 1.2 0.6 -0.7 1.0 1.1 -0.8 -0.9 -0.3
Intelligence (Savage-Jansen 2018) 0.9 2.9 5.5 1.2 -1.7 2.3 1.3 -1.2 -2.3 -1.2
Neuroticism (Nagel 2018) 0.7 1.8 3.3 1.3 0.4 1.8 1.8 -1.2 -1.6 -0.5
Schizophrenia (2018) 1.1 2.2 5.7 -0.1 0.5 -2.4 -1.1 1.2 2.3 1.2
Schizophrenia vs Biploar Disorder 0.4 0.6 1.5 0.8 -0.6 0.3 -0.7 -0.9 -0.4 1.2
Worry (Nagel 2018) 0.6 1.2 4.7 2.2 0.6 1.1 -0.1 -0.2 -1.1 1.0
Alzheimer’s Disease (in mother) 1.4 1.7 6.0 -1.3 -1.5 0.7 0.7 -0.4 -0.7 -2.5
Alzheimer’s Disease (in father) 0.4 0.4 1.8 0.2 -1.3 0.3 -0.9 -0.3 -0.2 -0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.8 -0.1 -1.3 -0.3 -0.3 0.6 0.1 -1.2
Crohns Disease (2017) 0.3 0.6 1.6 0.2 -0.6 0.8 1.3 -0.8 -0.8 -0.3
Irritable Bowel Disease (IBD) 0.4 1.0 1.8 0.5 -1.4 1.3 0.8 -0.8 -1.2 -0.4
Ulcerative Colitis (UC) 0.4 0.7 1.5 0.8 -1.1 1.2 -0.1 -0.5 -1.1 0.1
Major Depression (MDD) 1.2 1.5 4.8 1.4 0.7 1.3 2.2 -0.2 -1.2 -0.0
Reaction Time 0.4 0.8 1.9 -0.7 -0.9 1.3 -0.1 -0.4 -1.4 -0.6
Verbal and Numeric Reasoning (VNR) 1.9 4.5 8.7 0.2 -2.2 3.0 1.7 -2.2 -2.9 -1.1
Breast Cancer 0.2 0.4 1.6 -0.2 -0.2 0.2 1.3 -0.1 -0.3 -0.9
Ovarian Cancer 0.5 0.7 1.8 0.0 0.4 -1.4 -1.0 0.2 1.2 0.5
Prostate Cancer 0.4 0.6 1.2 0.1 -1.0 1.1 0.4 -0.7 -1.1 0.3
Age at First Birth 0.4 0.5 1.5 0.3 -0.0 -0.9 -0.5 1.2 0.8 0.7
Bipolar Disorder (2011) 1.4 1.4 3.3 0.9 1.1 -1.0 -0.4 1.5 0.9 1.8
Body Mass Index (BMI) (2010) 0.6 0.9 2.1 0.9 -0.2 -0.6 1.4 0.6 0.7 -1.4
Coronary Artery Disease (CAD) 0.5 0.6 2.0 0.2 -0.8 1.0 0.4 -1.4 -0.7 -0.4
Crohns Disease (2012) 0.4 0.7 1.8 0.9 0.0 -0.6 -1.3 0.3 0.6 1.2
Mean Putamen Volume 0.8 0.9 2.1 -0.6 -0.4 -1.4 0.6 1.0 1.4 -0.6
Fasting Glucose 0.2 0.3 0.7 -0.8 -0.5 0.2 0.9 -0.4 -0.1 -0.1
HbA1C 0.6 0.6 3.6 0.5 1.9 -0.2 0.4 -0.4 0.4 0.0
HDL Cholesterol 2.2 3.6 6.3 2.5 1.5 -1.7 -1.6 2.0 1.6 2.2
LDL Cholesterol 1.1 1.7 3.8 -1.4 -2.0 1.0 -1.1 -1.6 -1.0 -0.6
Lupus 1.2 1.9 5.4 -0.8 -0.9 1.7 -0.5 -2.3 -1.7 -0.3
Neuroticism (2016) 1.3 1.8 6.3 0.3 0.2 1.6 2.5 -1.0 -1.5 -0.8
Primary Biliary Cirrhosis 0.7 1.0 1.3 1.1 1.0 -1.1 -0.7 1.0 1.0 0.9
Rheumatoid Arthritis 0.2 0.2 0.6 -0.8 -0.7 -0.3 -0.3 0.0 0.4 0.4
Schizophrenia (2014) 0.9 1.9 4.1 -0.2 0.2 -2.0 -1.1 1.3 2.0 1.6
Triglycerides 1.4 2.3 6.4 -1.1 -0.3 1.8 0.8 -2.5 -1.8 -1.1
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.7 -0.2 0.4 -1.3 -0.2 0.5 1.2 -0.1
Ulcerative Colitis 0.8 1.2 3.1 1.4 -0.1 -0.9 -1.8 1.1 0.8 0.5
Blood Eosinophil Count 0.3 1.9 8.2 -0.4 0.7 0.9 1.0 -1.5 -0.8 -2.9
Blood Platelet Count 0.4 4.6 21.9 0.5 -1.8 1.5 0.9 -1.3 -1.4 -4.7
Blood Red Count 0.3 2.9 9.6 1.4 0.3 0.4 2.9 -0.5 -0.4 -3.1
Blood White Count 0.5 3.8 9.6 -1.8 -0.2 1.9 1.1 -2.3 -1.8 -3.1
Heel T-Score 0.2 2.0 8.6 -1.4 1.4 -0.1 2.9 0.2 0.0 -1.0
BMI 0.8 4.9 16.5 -0.9 1.2 0.6 3.8 -0.7 -0.6 -4.1
Height 0.5 9.1 31.5 5.6 2.3 -1.2 1.1 3.9 1.3 2.7
Waist Hip Ratio (WHR) 0.4 2.0 7.5 -2.7 -1.6 0.8 0.4 -1.4 -0.8 -0.4
Systolic Blood Pressure 0.2 1.0 3.6 0.1 1.1 -0.1 1.9 1.1 0.2 -0.7
Smoking Status 0.6 1.6 6.2 -0.9 -0.9 -0.3 1.7 0.1 0.3 -2.5
Allergy or Eczema 1.1 2.9 12.7 1.0 -1.5 0.3 -3.6 -0.4 -0.2 2.1
Cardiovascular Disease 0.3 1.1 6.6 -0.4 0.7 0.3 2.6 0.6 -0.3 -0.1
Hypothyroidism (self reported) 0.8 1.8 4.2 1.5 2.0 -0.6 -0.8 0.9 0.6 2.0
Respiratory disease 0.2 0.5 1.4 0.6 0.9 -0.4 0.5 1.2 0.4 0.5
Type 2 Diabetes (T2D) (2018) 0.3 0.5 2.8 0.7 0.3 0.4 1.7 0.1 -0.4 0.0
Lung FEV1/FVC ratio 0.5 2.6 9.1 1.1 -3.0 0.3 -0.6 0.1 -0.3 -2.7
Lung FVC 0.1 0.6 1.9 1.4 -0.5 -0.4 0.2 1.1 0.4 0.4
Neuroticism 0.3 0.8 2.4 1.6 0.8 0.9 1.1 -0.2 -0.8 0.2
Chronotype (morning person) 0.0 0.1 0.3 0.1 0.1 -0.1 -0.6 0.1 0.1 0.4
Hair Pigment 0.1 1.7 6.8 -0.6 2.6 -0.9 1.4 0.6 1.0 -0.9
Tanning 0.0 0.2 0.6 -0.3 0.2 0.2 0.4 -0.8 -0.3 -0.4
Hand grip strength (left) 1.0 2.5 10.0 0.3 1.1 1.4 3.2 -1.1 -1.4 -1.0
Number of treatments/medications taken 0.2 0.3 0.8 -0.8 0.5 0.1 0.9 -0.1 -0.0 -0.5
Average weekly spirits intake 1.6 1.9 3.0 -1.5 -1.7 1.0 -1.7 -1.5 -1.0 -1.0
Sensitivity / hurt feelings 1.1 2.0 5.4 -0.9 0.7 1.5 2.3 -1.4 -1.5 -0.7
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.5 0.1 -1.1 1.1 0.4 -1.2 -1.1 -0.8
Hearing difficulty/problems: Yes 2.1 3.3 13.0 0.8 1.5 1.6 3.6 -0.5 -1.6 -1.4
Relative age of first facial hair 0.1 0.3 0.9 0.4 0.9 -0.5 0.5 0.2 0.6 -0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.0 0.2 -0.5 -0.4 0.4 0.4 0.4 -1.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.6 -1.3 -0.5 0.7 0.6 -0.6 -0.7 -0.1
Ever had hysterectomy (womb removed) 1.1 1.3 3.8 0.5 -1.7 -0.8 -1.9 0.7 0.8 0.7
Systolic blood pressure, automated reading 1.1 3.2 9.7 -1.0 0.1 1.7 3.1 -1.1 -1.7 -2.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 3.2 1.2 -0.2 -0.1 0.1 0.8 0.1 1.8
Angina 0.4 0.5 1.7 -0.1 -0.8 0.1 -1.3 0.3 -0.1 1.1
Medication for hormone replacement therapy 1.1 1.2 3.0 -1.4 0.5 1.1 1.7 -0.9 -1.1 -0.2
Vitamin and mineral supplements 0.2 0.2 0.5 -0.7 -0.2 -0.2 0.6 -0.1 0.2 -0.7
Supplements: Zinc 1.1 1.1 3.6 1.9 0.8 -0.4 -1.2 0.4 0.4 1.4
Medication: Co-codamol 0.6 0.7 3.1 0.9 0.1 0.1 1.8 -0.4 -0.1 -1.0
Medication: Metformin 0.2 0.3 1.2 0.4 -0.4 0.4 1.1 -0.5 -0.4 0.0
Diabetes (father) 1.0 1.3 5.8 -1.1 0.0 -0.3 1.2 -0.2 0.4 -2.4
Diabetes (mother) 0.2 0.2 0.7 -0.8 0.6 -0.2 -0.8 -0.2 0.2 0.1
Severe depression (siblings) 0.3 0.4 0.7 0.8 -0.1 -0.7 0.4 0.5 0.7 -0.6
Pack years adult smoking proportion 0.3 0.5 0.9 -0.7 -0.3 -0.9 0.3 0.3 0.9 -1.0
Impedance of leg (right) 0.3 1.7 4.2 0.1 -1.9 0.7 -1.7 -0.4 -0.8 2.1
Leg fat-free mass (left) 0.6 3.3 6.7 1.8 2.6 -0.9 2.5 1.9 0.9 -1.3
Trunk fat percentage 0.8 3.0 11.1 0.4 1.0 1.4 3.3 -0.7 -1.5 -2.0
Hand grip strength (right) 0.5 1.4 5.0 1.6 1.5 0.3 2.2 -0.0 -0.2 -0.3
Townsend deprivation index at recruitment 0.4 0.6 1.4 -0.5 -1.2 0.7 0.8 -0.6 -0.7 -0.5
Current tobacco smoking 0.5 0.9 1.8 -0.8 -1.3 0.8 0.6 -0.4 -0.8 -1.4
Average weekly fortified wine intake 0.6 0.8 2.5 0.5 0.3 0.5 1.6 -0.6 -0.6 -1.2
Maternal smoking around birth 0.9 1.2 3.2 0.8 1.5 -1.0 1.8 0.9 1.0 -0.1
Fed-up feelings 0.9 1.6 3.4 0.4 -0.5 1.7 1.3 -1.8 -1.7 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.5 0.0 -0.9 1.2 1.1 -1.1 -1.2 -0.1
Relative age voice broke 0.7 1.1 4.6 1.5 0.6 -0.0 -0.8 0.1 0.1 2.1
Taking other prescription medications 0.6 0.9 1.4 1.0 1.2 -1.2 0.5 0.9 1.1 0.1
Age when periods started (menarche) 0.3 0.8 3.5 1.9 -0.2 0.6 1.0 -0.0 -0.6 0.7
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 4.8 -1.2 -1.3 2.2 1.9 -1.6 -2.1 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.3 -0.8 0.8 0.7 0.9 -0.8 -0.7 -1.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.3 0.1 0.4 0.1 1.0 -0.1 -0.0 -1.1
Qualifications: CSEs or equivalent 2.1 2.8 5.2 0.8 1.5 -2.3 -0.9 1.9 2.3 1.4
Serious illness, injury or assault to yourself 1.2 1.5 6.3 0.9 -2.5 1.1 0.0 -0.9 -1.0 -0.7
High blood pressure 0.5 1.4 4.6 -1.1 1.5 0.2 2.1 0.3 -0.2 -1.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 7.7 0.1 -1.1 0.6 -2.8 -0.6 -0.5 1.1
Multivitamins +/- minerals 0.6 0.7 2.1 0.2 1.5 -1.0 -0.3 0.6 1.0 0.6
Stomach or abdominal pain in last month 0.3 0.4 1.5 0.8 -1.2 0.0 -0.4 -0.5 -0.0 -0.4
Supplements: Glucosamine 0.4 0.5 1.0 -0.5 0.1 0.6 1.0 -0.5 -0.6 -1.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.1 0.0 -0.3 -0.8 -0.3 1.0 0.7 -0.3
Medication: Atenolol 0.2 0.3 0.8 -0.9 -0.4 0.3 0.4 -0.2 -0.3 -0.7
Medication: Levothyroxine sodium 1.4 2.4 3.3 1.3 1.4 -1.7 -1.2 1.7 1.7 1.8
Sitting height 0.5 3.6 8.1 2.8 1.2 -1.3 -1.2 2.5 1.4 2.1
Chronic bronchitis/emphysema (father) 0.4 0.5 1.6 0.1 1.3 0.6 0.2 -0.8 -0.7 0.3
High blood pressure (mother) 1.6 2.3 5.7 -1.3 0.7 1.2 2.4 -1.1 -1.2 -1.9
Body mass index (BMI) 1.0 4.4 12.6 -0.8 1.5 0.9 3.5 -1.0 -0.9 -3.5
Impedance of leg (left) 0.4 2.2 8.0 0.4 -1.7 0.3 -2.0 -0.1 -0.3 2.8
Leg predicted mass (left) 0.6 3.3 6.3 1.8 2.5 -1.0 2.5 1.9 1.0 -1.3
Trunk fat mass 0.7 2.9 11.3 1.3 1.7 0.8 3.4 0.2 -0.8 -1.8
Waist circumference 1.4 5.1 17.2 -0.7 1.1 1.1 4.2 -1.0 -1.1 -3.6
Number of incorrect matches in round 0.3 0.5 1.1 -0.9 1.0 -0.4 -1.0 -0.5 0.3 0.3
Past tobacco smoking 0.5 0.8 2.9 0.2 -0.1 0.4 -1.6 -0.2 -0.5 1.7
Alcohol usually taken with meals 0.1 0.2 0.4 0.6 0.5 -0.1 0.4 0.6 0.2 0.4
Nervous feelings 0.3 0.5 1.8 1.3 0.0 0.1 -0.5 0.8 -0.2 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 4.1 -0.6 -2.0 1.4 -0.0 -1.7 -1.4 -1.0
Hearing difficulty/problems with background noise 0.6 0.9 3.5 1.1 0.4 0.4 1.9 -0.2 -0.5 -1.1
Hair/balding pattern: Pattern 2 0.6 0.8 1.4 -0.4 0.3 -1.1 -1.1 0.5 1.2 1.0
Had menopause 0.7 0.8 1.5 -0.8 -1.1 0.9 1.2 -0.8 -0.9 -0.6
Had other major operations 0.1 0.1 0.3 -0.5 0.5 -0.3 0.2 0.3 0.3 0.4
Forced vital capacity (FVC) 0.8 3.0 6.9 2.4 1.4 -1.4 -0.4 2.6 1.4 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 3.4 0.6 1.8 0.1 1.4 0.2 -0.1 0.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.4 1.6 0.6 1.2 1.4 -0.5 -1.3 -0.4
Qualifications: None of the above 0.6 1.2 2.7 0.2 0.2 1.1 1.5 -1.0 -1.1 -1.6
Financial difficulties in last 2 years 0.7 0.9 2.2 0.2 -0.1 1.1 1.2 -1.5 -1.1 -0.3
Mouth/teeth dental problems 1.5 2.4 5.0 1.0 0.9 -1.3 -2.1 1.4 1.3 2.2
Heart attack 0.3 0.3 0.6 0.5 -0.8 -0.7 -0.2 0.6 0.6 -0.5
Allergy 0.5 1.1 2.1 0.3 1.1 -1.1 1.5 1.2 1.1 -0.8
Pain all over the body in last month 0.1 0.1 0.4 -0.6 0.0 -0.1 -0.3 0.3 0.2 0.4
Diabetes (self-reported) 0.2 0.3 1.2 0.3 -1.1 0.6 0.7 0.1 -0.5 0.2
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 3.0 -0.7 0.3 1.7 -0.0 -1.5 -1.7 -1.7
Medication: Ramipril 0.3 0.4 1.1 0.6 -0.3 0.0 1.0 0.5 0.0 -1.0
Medication: Simvastatin 1.9 2.8 7.1 -1.8 0.1 1.6 2.7 -1.3 -1.6 -1.5
Fluid intelligence score 0.9 1.9 3.6 1.6 -0.7 1.9 1.5 -0.8 -1.9 0.3
Illnesses of siblings 1.2 1.7 4.8 1.5 -0.4 -0.5 -2.2 0.5 0.5 1.9
Neuroticism score 0.4 0.8 1.8 1.3 -0.5 1.2 0.8 -0.5 -1.2 0.0
Weight 0.6 3.1 10.2 1.6 2.2 0.0 3.2 0.9 -0.0 -1.9
Impedance of arm (right) 0.2 1.0 2.2 1.3 -1.1 0.6 -0.9 0.4 -0.6 1.5
Arm fat percentage (right) 1.1 4.5 14.2 -0.1 1.4 1.3 3.8 -0.9 -1.3 -3.3
Trunk fat-free mass 1.1 6.2 11.6 3.3 3.0 -2.3 1.0 3.4 2.4 0.7
Hip circumference 1.0 4.1 13.5 1.9 2.5 -0.1 3.7 1.0 0.1 -2.1
Time employed in main current job 0.0 0.1 0.1 0.2 0.3 0.3 0.3 -0.1 -0.2 0.1
Alcohol intake versus 10 years previously 1.0 1.5 5.4 -0.3 -0.0 0.7 2.3 -0.3 -0.7 -1.9
Father’s age at death 2.2 2.9 4.5 1.9 2.1 -1.5 -0.8 1.9 1.5 1.9
Worrier / anxious feelings 0.4 0.7 1.6 1.3 -0.6 1.1 0.4 -0.5 -1.1 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 0.6 -0.2 -0.0 0.2 0.1 0.1 0.8
Falls in the last year 0.4 0.5 1.2 -0.1 0.1 1.1 -0.5 -0.9 -1.0 0.5
Hair/balding pattern: Pattern 3 0.4 0.6 2.9 1.7 -0.3 0.6 0.1 0.4 -0.5 0.7
Number of live births 2.5 3.6 5.9 -0.6 -2.1 1.8 1.4 -2.4 -1.8 -2.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.6 1.9 0.7 -0.9 -0.1 1.9 0.9 0.6
Pulse rate 0.3 0.5 1.0 0.2 -0.0 1.0 0.3 -1.0 -1.0 0.4
Happiness 1.3 1.6 2.8 1.0 -0.3 1.7 1.2 -1.2 -1.7 -1.1
Noisy workplace 1.2 1.5 4.5 -2.1 -1.3 0.4 0.3 -1.3 -0.4 -1.5
Qualifications: A levels/AS levels or equivalent 0.9 2.1 4.3 2.1 1.0 -0.8 -1.2 1.9 0.8 1.7
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.2 1.1 -0.2 0.7 0.0 0.2 -0.7 0.2
Mouth/teeth dental problems: Dentures 0.5 0.9 2.3 -1.0 -1.5 0.9 0.2 -0.6 -0.8 -1.1
Asthma 0.0 0.1 0.2 0.1 -0.1 0.5 0.1 -0.4 -0.4 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 5.1 -2.3 0.5 0.9 0.9 -1.7 -0.9 -1.5
Medication: Cholesterol lowering 0.2 0.3 0.9 -0.2 0.6 -0.5 0.2 0.9 0.6 -0.2
Depression (self-reported) 1.7 2.0 4.7 0.1 -1.4 1.9 0.6 -2.2 -1.9 0.0
Medication: Lansoprazole 1.3 1.5 3.5 1.1 -0.0 -1.9 -1.0 1.0 1.9 0.5
Prospective memory result 0.7 0.9 1.9 -0.5 -0.6 -1.0 -1.4 0.6 1.0 1.1
Lung cancer (father) 0.4 0.4 1.2 1.0 0.4 0.4 -0.5 -0.1 -0.3 1.1
Illnesses of mother 0.7 0.8 2.2 1.3 -0.2 -0.1 -1.5 0.3 0.1 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.4 1.6 -0.4 -0.2 -0.1 1.2 0.1 0.3
Pulse wave Arterial Stiffness index 0.5 0.6 1.4 -0.7 0.4 -0.3 1.2 1.0 0.2 -1.1
Impedance of arm (left) 0.2 1.1 2.3 0.9 -1.5 1.2 -0.4 -0.3 -1.2 1.1
Arm fat mass (right) 1.0 4.1 14.1 0.5 2.3 0.5 3.8 0.0 -0.5 -2.9
Trunk predicted mass 1.1 6.4 12.2 3.3 2.9 -2.4 0.9 3.5 2.4 0.7
Standing height 1.0 9.8 26.5 5.2 2.0 -2.0 -0.3 4.3 2.1 3.3
Length of working week for main job 0.4 0.5 1.4 1.0 -1.2 0.2 -0.9 -0.3 -0.1 -0.1
Exposure to tobacco smoke at home 0.3 0.3 1.2 -0.2 -0.9 -0.3 0.1 0.3 0.4 1.1
Breastfed as a baby 0.8 0.9 2.2 0.3 -0.3 -1.0 -1.0 1.0 1.0 1.5
Tense / ‘highly strung’ 1.3 2.2 5.0 -0.3 -1.0 2.2 0.4 -1.7 -2.2 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 4.9 7.4 14.7 -0.6 -2.3 3.8 2.2 -3.3 -3.8 -1.2
Hair/balding pattern: Pattern 4 0.3 0.8 2.2 -0.8 0.9 -0.1 0.5 1.5 0.0 1.2
Birth weight of first child 1.1 2.1 8.0 1.2 -0.0 -0.8 -2.8 1.0 0.8 1.7
Peak expiratory flow (PEF) 0.5 1.3 5.4 -0.5 0.6 0.6 2.3 -0.3 -0.6 -1.4
Pulse wave reflection index 1.2 1.4 2.2 -1.5 1.0 -1.4 0.3 0.9 1.3 -1.5
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.4 -0.6 0.9 -1.1 0.8 0.8 1.2 -0.8
Loud music exposure frequency 0.1 0.1 0.5 -0.3 -0.7 0.3 0.4 0.1 -0.4 -0.0
Qualifications: O levels/GCSEs or equivalent 2.3 3.7 10.0 1.7 0.9 -1.4 -2.1 1.9 1.4 3.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.5 -0.1 -0.1 0.9 1.6 -0.9 -1.0 -1.5
Blood clot in the leg (DVT) 0.6 0.7 3.3 0.1 0.4 0.5 1.8 -1.1 -0.4 -0.3
Medication: Paracetamol 0.9 1.4 2.4 -1.3 -0.0 1.4 1.5 -1.6 -1.4 -0.2
Headache pain in last month 2.4 4.2 9.2 -0.6 -1.6 3.0 1.1 -2.5 -3.0 -0.7
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.1 0.4 -0.9 1.2 0.2 -1.4 -1.2 0.5
Glaucoma (self-reported) 0.5 0.6 2.0 -1.4 -0.0 0.7 0.0 -1.0 -0.7 -0.7
Gout (self-reported) 0.6 0.8 2.1 -1.1 0.7 -0.9 -0.2 0.6 0.9 -1.5
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 4.2 1.6 2.0 -0.6 -0.3 0.7 0.5 2.0
Medication: Amlodipine 0.9 1.2 5.8 -0.6 2.4 -0.3 1.1 0.9 0.4 0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 -0.3 -0.7 -0.1 -0.2 -0.0 0.1 -0.6
Birth weight 1.0 2.1 5.0 0.9 -2.2 -0.9 -2.2 1.1 0.9 1.0
Chronic bronchitis/emphysema (mother) 1.5 1.8 5.4 -0.9 -0.7 -0.4 -2.3 0.3 0.3 2.3
High blood pressure (siblings) 2.1 3.0 4.8 -2.0 -0.5 1.6 2.0 -1.6 -1.6 -2.2
Forced vital capacity (FVC), Best measure 0.4 1.5 3.9 2.0 0.8 -0.7 -0.2 1.7 0.7 1.3
Body fat percentage 0.9 3.4 11.7 0.4 0.9 1.5 3.4 -1.0 -1.6 -2.4
Leg fat percentage (right) 1.3 4.6 12.5 -0.3 0.8 2.0 3.5 -1.8 -2.0 -2.8
Arm fat-free mass (right) 0.7 3.4 7.0 2.1 2.6 -1.5 1.6 2.3 1.5 0.1
Exposure to tobacco smoke outside home 0.4 0.5 1.7 1.0 -1.3 0.6 -0.1 -0.2 -0.5 -0.6
Comparative body size at age 10 1.0 2.8 5.6 -1.6 -1.2 1.6 1.9 -1.4 -1.6 -2.4
Number of full brothers 0.2 0.2 0.9 -0.1 -0.2 -0.5 -0.9 0.3 0.5 0.2
Worry too long after embarrassment 0.3 0.4 0.7 0.6 0.9 -0.7 -0.6 0.7 0.6 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 5.8 -1.5 -2.3 2.4 0.3 -2.4 -2.4 -0.2
Wheeze or whistling in the chest in last year 0.6 1.1 1.9 -0.1 -0.6 1.4 1.4 -0.9 -1.3 -1.1
Number of children fathered 0.9 1.0 3.5 1.9 -0.2 -0.2 -1.1 0.2 0.2 1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 3.7 -1.3 -1.5 1.6 -0.6 -1.9 -1.5 -0.7
Age at first live birth 0.9 1.6 3.8 0.5 1.9 -1.0 -0.2 1.6 1.0 1.6
Pulse wave peak to peak time 0.6 0.7 1.7 1.3 -0.2 0.1 -1.1 -0.6 -0.1 1.2
Health satisfaction 0.8 1.1 3.3 0.0 0.7 0.5 1.8 -1.1 -0.6 -1.4
Shortness of breath walking on level ground 0.7 0.9 1.9 1.4 0.0 1.0 0.7 -0.9 -1.1 0.7
Qualifications: College or University degree 0.0 0.1 0.6 -0.3 0.3 0.3 0.3 0.1 -0.3 -0.8
Eye problems/disorders: None of the above 0.1 0.1 0.3 -0.3 -0.1 -0.4 0.5 0.2 0.5 -0.3
Mouth/teeth dental problems: Loose teeth 1.2 1.5 3.7 -0.6 0.6 1.3 1.9 -1.5 -1.3 -0.8
Emphysema/chronic bronchitis 1.6 1.8 3.9 -0.9 -0.6 2.0 0.9 -1.5 -1.9 -0.9
Medication for pain relief, constipation, heartburn 2.1 3.5 9.1 2.1 0.2 -1.4 -3.0 1.6 1.4 2.2
Neck or shoulder pain in last month 0.3 0.4 1.6 1.3 -0.8 0.1 -0.4 -0.2 -0.1 0.5
Medication: Blood pressure 0.9 1.6 3.3 -0.1 1.8 -1.6 0.4 1.7 1.6 0.0
Angina (self-reported) 0.4 0.5 1.6 0.1 -0.9 0.3 -1.2 0.2 -0.3 0.9
Migraine (self-reported) 1.8 2.2 4.9 -0.7 0.3 2.1 1.6 -1.7 -2.2 -0.3
Medication: Ibuprofen 1.6 1.9 4.4 -2.1 0.3 1.0 0.9 -1.7 -0.9 -1.8
Medication: Allopurinol 0.6 0.8 1.7 -1.0 -0.5 -1.0 -0.3 0.8 0.9 -1.3
Medication: Omeprazole 1.5 1.8 7.6 0.8 -0.1 0.9 2.8 -0.2 -1.0 -1.5
Medication: Seretide 50 evohaler 0.3 0.3 1.4 0.2 0.6 0.2 1.2 0.6 -0.2 -0.2
Mean time to correctly identify matches 1.3 2.6 4.4 -1.5 -1.8 2.0 0.4 -1.3 -2.1 -1.5
Heart disease (mother) 0.5 0.7 2.9 0.1 -0.6 -0.5 1.7 0.7 0.4 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 2.3 0.6 1.2 -1.5 0.8 1.5 1.5 0.4
Whole body fat mass 0.8 3.2 12.3 0.9 1.6 0.9 3.5 -0.1 -0.9 -2.1
Leg fat mass (right) 0.9 3.4 11.8 0.4 1.5 1.1 3.4 -0.6 -1.1 -2.6
Arm predicted mass (right) 0.7 3.7 7.5 2.4 2.7 -1.6 1.4 2.5 1.6 0.3
Pulse rate, automated reading 0.2 0.8 1.7 -1.0 -0.3 1.0 -0.9 -1.3 -0.9 -0.2
Alcohol intake frequency. 0.3 0.6 1.5 1.0 0.5 0.8 1.2 -0.1 -0.8 0.1
Comparative height size at age 10 0.5 2.6 7.2 2.7 0.3 -1.4 0.4 2.4 1.5 0.9
Number of full sisters 1.8 2.2 5.3 2.3 -0.6 -1.7 -1.3 1.6 1.6 0.5
Suffer from ‘nerves’ 0.7 1.1 2.2 0.2 -0.7 1.5 0.8 -1.2 -1.5 -0.7
Overall health rating 0.8 1.8 3.8 -0.7 -0.0 1.6 1.6 -0.9 -1.6 -1.9
Chest pain or discomfort 1.1 1.6 7.6 -1.0 1.2 0.2 2.8 0.2 -0.1 -1.2
Had major operations 0.2 0.3 0.6 0.1 0.2 -0.7 -0.6 0.1 0.7 -0.8
Age at last live birth 0.2 0.3 1.0 0.3 1.0 -0.6 0.0 0.6 0.6 0.4
Family relationship satisfaction 0.6 0.7 3.1 0.5 -1.8 0.5 -0.2 -0.7 -0.6 -0.8
Leg pain on walking 0.3 0.4 0.9 -0.6 -0.2 0.1 0.8 -1.0 -0.1 -0.8
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 5.6 -1.2 -1.8 1.7 -0.9 -2.4 -1.6 -0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.9 0.7 1.0 0.1 0.3 0.1 -0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.4 -0.7 1.5 -0.9 0.2 0.6 0.8 -0.4
Medication: Aspirin 0.3 0.3 1.5 -1.2 -0.2 0.2 0.6 -0.4 -0.2 -0.5
Supplements: Vitamin C 1.0 1.2 2.0 0.6 -1.3 1.4 -0.5 -0.6 -1.4 1.3
Knee pain experienced in last month 0.9 1.3 4.1 -0.1 -2.0 0.9 0.4 -1.5 -0.9 -1.0
Hypertension (Self-reported) 0.4 1.1 4.0 -0.9 1.0 -0.1 2.0 0.7 0.1 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.2 0.7 1.1 -0.9 1.1 1.1 0.8 -1.0
Illnesses of father: Heart disease 1.4 1.9 3.1 -1.1 0.2 1.7 1.6 -1.0 -1.7 -1.8
Illnesses of siblings: Diabetes 1.9 2.3 3.8 1.9 1.7 -1.7 -0.1 1.9 1.7 0.6
Smoking status: Previous 0.3 0.4 1.6 -0.2 0.4 -0.3 1.2 0.2 0.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 3.7 1.5 0.4 -1.1 -0.9 1.9 1.2 1.2
Whole body fat-free mass 0.8 4.8 8.4 2.7 2.9 -1.8 1.6 2.9 1.9 0.0
Leg fat-free mass (right) 0.6 3.5 7.1 1.9 2.7 -1.2 2.2 2.1 1.3 -0.9
Arm fat percentage (left) 1.4 5.5 15.8 -0.2 1.1 1.8 4.0 -1.4 -1.8 -3.5
Average weekly red wine intake 1.2 1.8 3.5 0.2 -0.4 -1.8 -1.9 1.3 1.9 0.9
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.5 1.2 -0.8 0.5 0.3 0.7 -0.6 -0.4
Mood swings 1.8 3.3 6.6 0.2 -1.2 2.6 1.9 -2.1 -2.6 -0.9
Loneliness, isolation 0.9 1.2 7.9 0.1 -2.8 0.2 -0.6 -0.2 -0.2 -0.6
Long-standing illness, disability or infirmity 0.1 0.2 0.8 0.1 -0.2 0.0 0.9 -0.4 -0.0 -0.3
Ever had bowel cancer screening 0.6 0.7 1.2 -0.5 -1.0 -1.1 -1.0 0.6 1.1 -0.6
Diabetes diagnosed by doctor 0.2 0.4 0.8 0.9 -0.2 0.5 0.8 -0.0 -0.5 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.1 0.3 0.1 -0.1 -0.3 -0.1 0.1 -0.1
Friendships satisfaction 0.3 0.4 2.1 1.5 -0.3 0.0 -0.0 0.7 0.0 0.0
Qualifications: nursing, teaching 0.3 0.5 2.3 0.1 -1.2 -0.0 -1.5 0.2 0.0 0.0
Commuting to job workplace: Walk 0.6 0.6 2.5 0.4 -0.7 0.7 1.6 -0.1 -0.7 0.3
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.0 0.6 -0.4 -0.4 0.1 0.4 0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.9 0.0 0.0 0.9 1.4 -0.9 -0.9 -1.1
Medication for cholesterol 1.9 2.8 6.2 1.7 0.5 -1.6 -2.5 1.4 1.6 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 -0.2 0.5 0.5 1.0 0.1 -0.6 -0.8
Back pain experienced in last month 0.5 0.7 2.3 -0.2 -1.1 -0.6 -1.5 0.6 0.6 0.1
Mineral and other dietary supplements 0.4 0.6 1.7 0.4 1.3 -0.3 -0.8 0.7 0.2 0.9
Breast cancer (self-reported) 0.2 0.3 1.0 -1.0 0.0 -0.2 -0.6 -0.1 0.2 -0.6
Asthma (self-reported) 0.1 0.2 0.5 -0.1 0.1 0.5 0.7 -0.5 -0.4 -0.2
Osteoporosis (self-reported) 0.5 0.7 3.4 0.7 -0.4 -0.5 -0.2 0.3 0.5 1.8
Osteoarthritis (self-reported) 1.8 2.3 6.1 0.2 2.5 -2.0 0.6 1.1 1.9 -1.0
Medication: Aspirin 0.5 0.6 2.1 -1.5 0.0 0.3 1.0 -0.4 -0.3 -1.0
Medication: Gliclazide 0.4 0.4 1.8 0.5 0.3 -0.4 1.3 0.6 0.4 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.2 0.8 -0.1 -0.0 -0.3 -0.8 0.1 0.3 0.9
Smoking status: Current 0.3 0.5 1.5 -0.4 -1.2 0.3 0.4 0.0 -0.3 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.0 1.4 0.5 0.0 0.7 0.3 -0.1 -1.1
Whole body water mass 0.8 4.7 8.6 2.6 2.9 -1.8 1.6 2.8 1.9 -0.1
Leg predicted mass (right) 0.6 3.4 6.8 1.9 2.6 -1.3 2.1 2.2 1.3 -0.8
Arm fat mass (left) 0.9 3.8 13.7 0.6 1.8 0.7 3.7 -0.1 -0.7 -2.9
Number of self-reported non-cancer illnesses 0.6 1.1 4.3 0.6 2.1 -0.7 0.8 1.1 0.7 0.2
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.1 0.7 0.8 0.1 -0.9 -0.8 -0.5
Miserableness 0.9 1.6 3.6 0.0 -0.3 1.4 1.9 -1.2 -1.4 -1.5
Guilty feelings 1.6 2.3 4.5 0.5 -1.3 2.1 1.3 -1.9 -2.1 -0.3
Wears glasses or contact lenses 2.0 2.3 5.7 -1.2 1.4 1.2 2.4 -1.6 -1.3 -1.2
Ever taken oral contraceptive pill 0.8 0.8 2.1 -0.7 -0.5 -1.1 -1.4 0.0 1.1 0.9
Hearing aid user 0.6 0.6 1.2 0.2 0.6 -1.1 0.5 0.9 1.1 0.8
Mother’s age at death 1.8 2.3 3.8 -1.2 -1.2 1.9 1.6 -1.5 -1.9 -0.8
Financial situation satisfaction 0.5 0.6 1.8 -0.2 1.0 0.6 1.3 -0.8 -0.5 -0.2
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.9 -0.9 0.2 -0.2 0.9 -0.3 0.2 -0.4
Commuting to job workplace: Public transport 0.3 0.3 0.5 -0.6 -0.6 0.6 0.7 -0.3 -0.6 -0.2
Eye problems/disorders: Glaucoma 1.1 1.3 2.3 -1.5 -0.4 1.4 0.1 -1.3 -1.5 -0.9
Medication: Blood pressure 1.4 2.6 8.8 -1.2 -1.0 1.1 2.0 -0.7 -1.1 -3.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 -0.1 -0.3 0.3 -0.6 -0.3 -0.3 -0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.5 0.2 -1.2 -0.5 -0.7 0.0 0.6 0.1
High cholesterol (Self-reported) 0.4 0.7 2.1 -1.4 1.2 0.2 1.0 0.0 -0.2 0.1
Medication: Bendroflumethiazide 0.4 0.6 1.8 0.7 0.7 -0.3 1.3 0.9 0.4 -0.6
Medication: Paracetamol 0.9 1.4 2.5 -1.0 -0.2 1.4 1.6 -1.6 -1.4 -0.6
Medication: Lisinopril 0.2 0.3 1.6 0.2 -0.4 -0.0 -0.3 -0.2 -0.0 1.3
Medication: Atorvastatin 1.2 1.5 3.0 0.1 1.3 -1.7 -0.5 1.6 1.7 0.4
Illnesses of father: High blood pressure 0.7 0.9 3.1 -1.1 0.9 -0.2 1.8 -0.2 0.2 -1.0
Alcohol drinker status: Never 1.9 2.3 4.4 0.9 -0.3 -2.1 -1.2 2.1 2.1 0.8
Ever smoked 0.7 1.3 4.5 -0.9 -0.8 0.2 1.6 -0.6 -0.1 -2.1
Basal metabolic rate 0.7 4.1 8.1 2.5 2.8 -1.4 2.1 2.5 1.5 -0.5
Leg fat percentage (left) 1.0 3.8 12.0 -0.1 1.1 1.6 3.5 -1.4 -1.6 -2.5
Arm fat-free mass (left) 0.9 4.5 9.4 2.2 3.1 -1.9 1.4 2.8 2.0 0.2
Number of operations (self-reported) 0.6 0.8 3.2 -1.1 0.3 0.3 0.5 -0.9 -0.3 -1.8
Average weekly beer plus cider intake 0.8 1.2 3.2 -1.3 0.4 1.0 -0.7 -1.8 -1.0 0.8
Irritability 0.4 0.7 1.8 1.0 1.0 -0.6 1.3 0.3 0.6 -0.9
Risk taking 0.7 1.0 2.2 -0.0 -1.5 1.2 0.1 -1.2 -1.1 -1.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.4 0.1 0.6 -0.5 0.0 0.8 0.4 -1.2
Fractured/broken bones in last 5 years 0.4 0.5 1.2 -0.3 -0.3 -1.1 -0.9 0.1 1.1 -0.2
Age started oral contraceptive pill 0.8 1.1 2.0 -1.2 -0.7 1.3 -0.1 -1.4 -1.3 -0.5
Diastolic blood pressure, automated reading 0.5 1.5 4.0 -1.3 0.8 1.2 2.0 -0.5 -1.2 -1.2
Ever depressed for a whole week 1.3 1.6 2.8 1.5 -0.2 1.4 1.7 -0.7 -1.4 -1.2
Unable to work because of sickness or disability 0.2 0.3 0.8 0.9 -0.9 0.4 0.3 -0.4 -0.4 0.0
Commuting to job workplace: Cycle 1.6 1.9 3.2 0.1 -0.8 1.8 -0.7 -1.8 -1.8 1.6
Myopia 0.9 1.3 4.6 -1.0 2.1 -1.1 1.1 0.6 1.0 -0.3
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.7 1.4 -0.7 -0.4 -2.2 -0.1 0.4 1.3
Cholesterol lowering medication 1.1 1.6 3.3 -1.6 0.3 1.2 1.8 -1.2 -1.2 -0.9
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 7.9 1.0 -0.1 0.7 2.8 -0.5 -0.8 -1.9
Pain experienced in last month 0.4 0.7 1.5 -0.5 1.2 -0.9 0.5 1.0 0.9 -0.7
Supplements: Calcium 0.4 0.4 1.2 1.1 0.6 0.2 0.7 0.8 -0.2 0.4
Basal cell carcinoma (self-reported) 0.7 0.8 1.7 -0.5 -0.7 -1.1 -0.0 1.3 1.1 -1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.2 -0.9 -0.6 -0.2 0.5 0.6 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 3.0 -0.1 0.4 0.4 1.7 -1.2 -0.4 -0.1
Heart disease (siblings) 1.8 2.2 5.3 0.4 1.2 -1.9 0.2 2.3 1.9 1.1
Alcohol drinker status: Previous 1.2 1.4 4.9 -1.1 2.2 0.6 1.1 -0.3 -0.5 -1.2
Pack years of smoking 0.2 0.3 0.9 -0.5 -0.2 -0.7 0.3 0.2 0.7 -0.9
Impedance of whole body 0.4 1.8 4.7 0.5 -1.9 0.9 -1.5 -0.3 -1.0 2.2
Leg fat mass (left) 0.8 3.0 11.0 0.6 1.7 0.7 3.3 -0.2 -0.7 -2.4
Arm predicted mass (left) 0.8 4.2 8.9 2.2 3.0 -1.8 1.2 2.7 1.8 0.2