Hub : Genes

CYP4X1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.037	0.0160	2.0e-03	0.004	0.035	0.012	0.034	0.005	8.5e-02	3.4e-05	1.1e-02	4.6e-05	7.4e-02
2	GTEx	Adipose Subcutaneous	0.085	0.0290	2.1e-04	0.040	NA	0.059	NA	0.050	3.3e-04	NA	1.5e-05	NA	5.8e-05
3	GTEx	Esophagus Mucosa	0.139	0.0530	1.3e-03	0.086	NA	0.052	NA	0.079	2.3e-06	NA	2.2e-04	NA	5.6e-06
4	GTEx	Skin Sun Exposed Lower leg	0.132	0.0420	3.6e-05	0.022	NA	0.048	NA	0.044	5.7e-03	NA	7.9e-05	NA	1.5e-04
5	GTEx	Testis	0.203	0.0700	3.2e-05	0.104	NA	0.081	NA	0.096	2.4e-05	NA	1.9e-04	NA	5.0e-05
6	GTEx	Thyroid	0.079	0.0320	1.5e-03	0.060	NA	0.030	NA	0.057	2.3e-05	NA	2.3e-03	NA	3.7e-05
7	ROSMAP	Brain Pre-frontal Cortex	0.054	0.0232	4.3e-04	0.012	0.028	0.001	0.025	0.006	8.6e-03	1.5e-04	2.0e-01	2.8e-04	5.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.5	0.5	-0.5	0.3	0.8	0.5	0.3
Bipolar Disorder or Schizophrenia	0.8	2.0	4.8	-0.3	0.7	-2.2	-0.7	1.4	2.1	1.1
Depressed Affect (Nagel 2018)	1.0	2.2	4.1	0.7	-0.4	2.0	1.9	-1.5	-1.9	-0.9
Depression (Nagel 2018)	0.4	0.7	1.2	0.6	-0.7	1.0	1.1	-0.8	-0.9	-0.3
Intelligence (Savage-Jansen 2018)	0.9	2.9	5.5	1.2	-1.7	2.3	1.3	-1.2	-2.3	-1.2
Neuroticism (Nagel 2018)	0.7	1.8	3.3	1.3	0.4	1.8	1.8	-1.2	-1.6	-0.5
Schizophrenia (2018)	1.1	2.2	5.7	-0.1	0.5	-2.4	-1.1	1.2	2.3	1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.5	0.8	-0.6	0.3	-0.7	-0.9	-0.4	1.2
Worry (Nagel 2018)	0.6	1.2	4.7	2.2	0.6	1.1	-0.1	-0.2	-1.1	1.0
Alzheimer’s Disease (in mother)	1.4	1.7	6.0	-1.3	-1.5	0.7	0.7	-0.4	-0.7	-2.5
Alzheimer’s Disease (in father)	0.4	0.4	1.8	0.2	-1.3	0.3	-0.9	-0.3	-0.2	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.8	-0.1	-1.3	-0.3	-0.3	0.6	0.1	-1.2
Crohns Disease (2017)	0.3	0.6	1.6	0.2	-0.6	0.8	1.3	-0.8	-0.8	-0.3
Irritable Bowel Disease (IBD)	0.4	1.0	1.8	0.5	-1.4	1.3	0.8	-0.8	-1.2	-0.4
Ulcerative Colitis (UC)	0.4	0.7	1.5	0.8	-1.1	1.2	-0.1	-0.5	-1.1	0.1
Major Depression (MDD)	1.2	1.5	4.8	1.4	0.7	1.3	2.2	-0.2	-1.2	-0.0
Reaction Time	0.4	0.8	1.9	-0.7	-0.9	1.3	-0.1	-0.4	-1.4	-0.6
Verbal and Numeric Reasoning (VNR)	1.9	4.5	8.7	0.2	-2.2	3.0	1.7	-2.2	-2.9	-1.1
Breast Cancer	0.2	0.4	1.6	-0.2	-0.2	0.2	1.3	-0.1	-0.3	-0.9
Ovarian Cancer	0.5	0.7	1.8	0.0	0.4	-1.4	-1.0	0.2	1.2	0.5
Prostate Cancer	0.4	0.6	1.2	0.1	-1.0	1.1	0.4	-0.7	-1.1	0.3
Age at First Birth	0.4	0.5	1.5	0.3	-0.0	-0.9	-0.5	1.2	0.8	0.7
Bipolar Disorder (2011)	1.4	1.4	3.3	0.9	1.1	-1.0	-0.4	1.5	0.9	1.8
Body Mass Index (BMI) (2010)	0.6	0.9	2.1	0.9	-0.2	-0.6	1.4	0.6	0.7	-1.4
Coronary Artery Disease (CAD)	0.5	0.6	2.0	0.2	-0.8	1.0	0.4	-1.4	-0.7	-0.4
Crohns Disease (2012)	0.4	0.7	1.8	0.9	0.0	-0.6	-1.3	0.3	0.6	1.2
Mean Putamen Volume	0.8	0.9	2.1	-0.6	-0.4	-1.4	0.6	1.0	1.4	-0.6
Fasting Glucose	0.2	0.3	0.7	-0.8	-0.5	0.2	0.9	-0.4	-0.1	-0.1
HbA1C	0.6	0.6	3.6	0.5	1.9	-0.2	0.4	-0.4	0.4	0.0
HDL Cholesterol	2.2	3.6	6.3	2.5	1.5	-1.7	-1.6	2.0	1.6	2.2
LDL Cholesterol	1.1	1.7	3.8	-1.4	-2.0	1.0	-1.1	-1.6	-1.0	-0.6
Lupus	1.2	1.9	5.4	-0.8	-0.9	1.7	-0.5	-2.3	-1.7	-0.3
Neuroticism (2016)	1.3	1.8	6.3	0.3	0.2	1.6	2.5	-1.0	-1.5	-0.8
Primary Biliary Cirrhosis	0.7	1.0	1.3	1.1	1.0	-1.1	-0.7	1.0	1.0	0.9
Rheumatoid Arthritis	0.2	0.2	0.6	-0.8	-0.7	-0.3	-0.3	0.0	0.4	0.4
Schizophrenia (2014)	0.9	1.9	4.1	-0.2	0.2	-2.0	-1.1	1.3	2.0	1.6
Triglycerides	1.4	2.3	6.4	-1.1	-0.3	1.8	0.8	-2.5	-1.8	-1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.7	-0.2	0.4	-1.3	-0.2	0.5	1.2	-0.1
Ulcerative Colitis	0.8	1.2	3.1	1.4	-0.1	-0.9	-1.8	1.1	0.8	0.5
Blood Eosinophil Count	0.3	1.9	8.2	-0.4	0.7	0.9	1.0	-1.5	-0.8	-2.9
Blood Platelet Count	0.4	4.6	21.9	0.5	-1.8	1.5	0.9	-1.3	-1.4	-4.7
Blood Red Count	0.3	2.9	9.6	1.4	0.3	0.4	2.9	-0.5	-0.4	-3.1
Blood White Count	0.5	3.8	9.6	-1.8	-0.2	1.9	1.1	-2.3	-1.8	-3.1
Heel T-Score	0.2	2.0	8.6	-1.4	1.4	-0.1	2.9	0.2	0.0	-1.0
BMI	0.8	4.9	16.5	-0.9	1.2	0.6	3.8	-0.7	-0.6	-4.1
Height	0.5	9.1	31.5	5.6	2.3	-1.2	1.1	3.9	1.3	2.7
Waist Hip Ratio (WHR)	0.4	2.0	7.5	-2.7	-1.6	0.8	0.4	-1.4	-0.8	-0.4
Systolic Blood Pressure	0.2	1.0	3.6	0.1	1.1	-0.1	1.9	1.1	0.2	-0.7
Smoking Status	0.6	1.6	6.2	-0.9	-0.9	-0.3	1.7	0.1	0.3	-2.5
Allergy or Eczema	1.1	2.9	12.7	1.0	-1.5	0.3	-3.6	-0.4	-0.2	2.1
Cardiovascular Disease	0.3	1.1	6.6	-0.4	0.7	0.3	2.6	0.6	-0.3	-0.1
Hypothyroidism (self reported)	0.8	1.8	4.2	1.5	2.0	-0.6	-0.8	0.9	0.6	2.0
Respiratory disease	0.2	0.5	1.4	0.6	0.9	-0.4	0.5	1.2	0.4	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.8	0.7	0.3	0.4	1.7	0.1	-0.4	0.0
Lung FEV1/FVC ratio	0.5	2.6	9.1	1.1	-3.0	0.3	-0.6	0.1	-0.3	-2.7
Lung FVC	0.1	0.6	1.9	1.4	-0.5	-0.4	0.2	1.1	0.4	0.4
Neuroticism	0.3	0.8	2.4	1.6	0.8	0.9	1.1	-0.2	-0.8	0.2
Chronotype (morning person)	0.0	0.1	0.3	0.1	0.1	-0.1	-0.6	0.1	0.1	0.4
Hair Pigment	0.1	1.7	6.8	-0.6	2.6	-0.9	1.4	0.6	1.0	-0.9
Tanning	0.0	0.2	0.6	-0.3	0.2	0.2	0.4	-0.8	-0.3	-0.4
Hand grip strength (left)	1.0	2.5	10.0	0.3	1.1	1.4	3.2	-1.1	-1.4	-1.0
Number of treatments/medications taken	0.2	0.3	0.8	-0.8	0.5	0.1	0.9	-0.1	-0.0	-0.5
Average weekly spirits intake	1.6	1.9	3.0	-1.5	-1.7	1.0	-1.7	-1.5	-1.0	-1.0
Sensitivity / hurt feelings	1.1	2.0	5.4	-0.9	0.7	1.5	2.3	-1.4	-1.5	-0.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	0.1	-1.1	1.1	0.4	-1.2	-1.1	-0.8
Hearing difficulty/problems: Yes	2.1	3.3	13.0	0.8	1.5	1.6	3.6	-0.5	-1.6	-1.4
Relative age of first facial hair	0.1	0.3	0.9	0.4	0.9	-0.5	0.5	0.2	0.6	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.2	-0.5	-0.4	0.4	0.4	0.4	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	-1.3	-0.5	0.7	0.6	-0.6	-0.7	-0.1
Ever had hysterectomy (womb removed)	1.1	1.3	3.8	0.5	-1.7	-0.8	-1.9	0.7	0.8	0.7
Systolic blood pressure, automated reading	1.1	3.2	9.7	-1.0	0.1	1.7	3.1	-1.1	-1.7	-2.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.2	1.2	-0.2	-0.1	0.1	0.8	0.1	1.8
Angina	0.4	0.5	1.7	-0.1	-0.8	0.1	-1.3	0.3	-0.1	1.1
Medication for hormone replacement therapy	1.1	1.2	3.0	-1.4	0.5	1.1	1.7	-0.9	-1.1	-0.2
Vitamin and mineral supplements	0.2	0.2	0.5	-0.7	-0.2	-0.2	0.6	-0.1	0.2	-0.7
Supplements: Zinc	1.1	1.1	3.6	1.9	0.8	-0.4	-1.2	0.4	0.4	1.4
Medication: Co-codamol	0.6	0.7	3.1	0.9	0.1	0.1	1.8	-0.4	-0.1	-1.0
Medication: Metformin	0.2	0.3	1.2	0.4	-0.4	0.4	1.1	-0.5	-0.4	0.0
Diabetes (father)	1.0	1.3	5.8	-1.1	0.0	-0.3	1.2	-0.2	0.4	-2.4
Diabetes (mother)	0.2	0.2	0.7	-0.8	0.6	-0.2	-0.8	-0.2	0.2	0.1
Severe depression (siblings)	0.3	0.4	0.7	0.8	-0.1	-0.7	0.4	0.5	0.7	-0.6
Pack years adult smoking proportion	0.3	0.5	0.9	-0.7	-0.3	-0.9	0.3	0.3	0.9	-1.0
Impedance of leg (right)	0.3	1.7	4.2	0.1	-1.9	0.7	-1.7	-0.4	-0.8	2.1
Leg fat-free mass (left)	0.6	3.3	6.7	1.8	2.6	-0.9	2.5	1.9	0.9	-1.3
Trunk fat percentage	0.8	3.0	11.1	0.4	1.0	1.4	3.3	-0.7	-1.5	-2.0
Hand grip strength (right)	0.5	1.4	5.0	1.6	1.5	0.3	2.2	-0.0	-0.2	-0.3
Townsend deprivation index at recruitment	0.4	0.6	1.4	-0.5	-1.2	0.7	0.8	-0.6	-0.7	-0.5
Current tobacco smoking	0.5	0.9	1.8	-0.8	-1.3	0.8	0.6	-0.4	-0.8	-1.4
Average weekly fortified wine intake	0.6	0.8	2.5	0.5	0.3	0.5	1.6	-0.6	-0.6	-1.2
Maternal smoking around birth	0.9	1.2	3.2	0.8	1.5	-1.0	1.8	0.9	1.0	-0.1
Fed-up feelings	0.9	1.6	3.4	0.4	-0.5	1.7	1.3	-1.8	-1.7	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	0.0	-0.9	1.2	1.1	-1.1	-1.2	-0.1
Relative age voice broke	0.7	1.1	4.6	1.5	0.6	-0.0	-0.8	0.1	0.1	2.1
Taking other prescription medications	0.6	0.9	1.4	1.0	1.2	-1.2	0.5	0.9	1.1	0.1
Age when periods started (menarche)	0.3	0.8	3.5	1.9	-0.2	0.6	1.0	-0.0	-0.6	0.7
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.8	-1.2	-1.3	2.2	1.9	-1.6	-2.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	-0.8	0.8	0.7	0.9	-0.8	-0.7	-1.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.3	0.1	0.4	0.1	1.0	-0.1	-0.0	-1.1
Qualifications: CSEs or equivalent	2.1	2.8	5.2	0.8	1.5	-2.3	-0.9	1.9	2.3	1.4
Serious illness, injury or assault to yourself	1.2	1.5	6.3	0.9	-2.5	1.1	0.0	-0.9	-1.0	-0.7
High blood pressure	0.5	1.4	4.6	-1.1	1.5	0.2	2.1	0.3	-0.2	-1.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	7.7	0.1	-1.1	0.6	-2.8	-0.6	-0.5	1.1
Multivitamins +/- minerals	0.6	0.7	2.1	0.2	1.5	-1.0	-0.3	0.6	1.0	0.6
Stomach or abdominal pain in last month	0.3	0.4	1.5	0.8	-1.2	0.0	-0.4	-0.5	-0.0	-0.4
Supplements: Glucosamine	0.4	0.5	1.0	-0.5	0.1	0.6	1.0	-0.5	-0.6	-1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	0.0	-0.3	-0.8	-0.3	1.0	0.7	-0.3
Medication: Atenolol	0.2	0.3	0.8	-0.9	-0.4	0.3	0.4	-0.2	-0.3	-0.7
Medication: Levothyroxine sodium	1.4	2.4	3.3	1.3	1.4	-1.7	-1.2	1.7	1.7	1.8
Sitting height	0.5	3.6	8.1	2.8	1.2	-1.3	-1.2	2.5	1.4	2.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	0.1	1.3	0.6	0.2	-0.8	-0.7	0.3
High blood pressure (mother)	1.6	2.3	5.7	-1.3	0.7	1.2	2.4	-1.1	-1.2	-1.9
Body mass index (BMI)	1.0	4.4	12.6	-0.8	1.5	0.9	3.5	-1.0	-0.9	-3.5
Impedance of leg (left)	0.4	2.2	8.0	0.4	-1.7	0.3	-2.0	-0.1	-0.3	2.8
Leg predicted mass (left)	0.6	3.3	6.3	1.8	2.5	-1.0	2.5	1.9	1.0	-1.3
Trunk fat mass	0.7	2.9	11.3	1.3	1.7	0.8	3.4	0.2	-0.8	-1.8
Waist circumference	1.4	5.1	17.2	-0.7	1.1	1.1	4.2	-1.0	-1.1	-3.6
Number of incorrect matches in round	0.3	0.5	1.1	-0.9	1.0	-0.4	-1.0	-0.5	0.3	0.3
Past tobacco smoking	0.5	0.8	2.9	0.2	-0.1	0.4	-1.6	-0.2	-0.5	1.7
Alcohol usually taken with meals	0.1	0.2	0.4	0.6	0.5	-0.1	0.4	0.6	0.2	0.4
Nervous feelings	0.3	0.5	1.8	1.3	0.0	0.1	-0.5	0.8	-0.2	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.1	-0.6	-2.0	1.4	-0.0	-1.7	-1.4	-1.0
Hearing difficulty/problems with background noise	0.6	0.9	3.5	1.1	0.4	0.4	1.9	-0.2	-0.5	-1.1
Hair/balding pattern: Pattern 2	0.6	0.8	1.4	-0.4	0.3	-1.1	-1.1	0.5	1.2	1.0
Had menopause	0.7	0.8	1.5	-0.8	-1.1	0.9	1.2	-0.8	-0.9	-0.6
Had other major operations	0.1	0.1	0.3	-0.5	0.5	-0.3	0.2	0.3	0.3	0.4
Forced vital capacity (FVC)	0.8	3.0	6.9	2.4	1.4	-1.4	-0.4	2.6	1.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.4	0.6	1.8	0.1	1.4	0.2	-0.1	0.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.4	1.6	0.6	1.2	1.4	-0.5	-1.3	-0.4
Qualifications: None of the above	0.6	1.2	2.7	0.2	0.2	1.1	1.5	-1.0	-1.1	-1.6
Financial difficulties in last 2 years	0.7	0.9	2.2	0.2	-0.1	1.1	1.2	-1.5	-1.1	-0.3
Mouth/teeth dental problems	1.5	2.4	5.0	1.0	0.9	-1.3	-2.1	1.4	1.3	2.2
Heart attack	0.3	0.3	0.6	0.5	-0.8	-0.7	-0.2	0.6	0.6	-0.5
Allergy	0.5	1.1	2.1	0.3	1.1	-1.1	1.5	1.2	1.1	-0.8
Pain all over the body in last month	0.1	0.1	0.4	-0.6	0.0	-0.1	-0.3	0.3	0.2	0.4
Diabetes (self-reported)	0.2	0.3	1.2	0.3	-1.1	0.6	0.7	0.1	-0.5	0.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.0	-0.7	0.3	1.7	-0.0	-1.5	-1.7	-1.7
Medication: Ramipril	0.3	0.4	1.1	0.6	-0.3	0.0	1.0	0.5	0.0	-1.0
Medication: Simvastatin	1.9	2.8	7.1	-1.8	0.1	1.6	2.7	-1.3	-1.6	-1.5
Fluid intelligence score	0.9	1.9	3.6	1.6	-0.7	1.9	1.5	-0.8	-1.9	0.3
Illnesses of siblings	1.2	1.7	4.8	1.5	-0.4	-0.5	-2.2	0.5	0.5	1.9
Neuroticism score	0.4	0.8	1.8	1.3	-0.5	1.2	0.8	-0.5	-1.2	0.0
Weight	0.6	3.1	10.2	1.6	2.2	0.0	3.2	0.9	-0.0	-1.9
Impedance of arm (right)	0.2	1.0	2.2	1.3	-1.1	0.6	-0.9	0.4	-0.6	1.5
Arm fat percentage (right)	1.1	4.5	14.2	-0.1	1.4	1.3	3.8	-0.9	-1.3	-3.3
Trunk fat-free mass	1.1	6.2	11.6	3.3	3.0	-2.3	1.0	3.4	2.4	0.7
Hip circumference	1.0	4.1	13.5	1.9	2.5	-0.1	3.7	1.0	0.1	-2.1
Time employed in main current job	0.0	0.1	0.1	0.2	0.3	0.3	0.3	-0.1	-0.2	0.1
Alcohol intake versus 10 years previously	1.0	1.5	5.4	-0.3	-0.0	0.7	2.3	-0.3	-0.7	-1.9
Father’s age at death	2.2	2.9	4.5	1.9	2.1	-1.5	-0.8	1.9	1.5	1.9
Worrier / anxious feelings	0.4	0.7	1.6	1.3	-0.6	1.1	0.4	-0.5	-1.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.6	-0.2	-0.0	0.2	0.1	0.1	0.8
Falls in the last year	0.4	0.5	1.2	-0.1	0.1	1.1	-0.5	-0.9	-1.0	0.5
Hair/balding pattern: Pattern 3	0.4	0.6	2.9	1.7	-0.3	0.6	0.1	0.4	-0.5	0.7
Number of live births	2.5	3.6	5.9	-0.6	-2.1	1.8	1.4	-2.4	-1.8	-2.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.6	1.9	0.7	-0.9	-0.1	1.9	0.9	0.6
Pulse rate	0.3	0.5	1.0	0.2	-0.0	1.0	0.3	-1.0	-1.0	0.4
Happiness	1.3	1.6	2.8	1.0	-0.3	1.7	1.2	-1.2	-1.7	-1.1
Noisy workplace	1.2	1.5	4.5	-2.1	-1.3	0.4	0.3	-1.3	-0.4	-1.5
Qualifications: A levels/AS levels or equivalent	0.9	2.1	4.3	2.1	1.0	-0.8	-1.2	1.9	0.8	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	1.1	-0.2	0.7	0.0	0.2	-0.7	0.2
Mouth/teeth dental problems: Dentures	0.5	0.9	2.3	-1.0	-1.5	0.9	0.2	-0.6	-0.8	-1.1
Asthma	0.0	0.1	0.2	0.1	-0.1	0.5	0.1	-0.4	-0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.1	-2.3	0.5	0.9	0.9	-1.7	-0.9	-1.5
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.2	0.6	-0.5	0.2	0.9	0.6	-0.2
Depression (self-reported)	1.7	2.0	4.7	0.1	-1.4	1.9	0.6	-2.2	-1.9	0.0
Medication: Lansoprazole	1.3	1.5	3.5	1.1	-0.0	-1.9	-1.0	1.0	1.9	0.5
Prospective memory result	0.7	0.9	1.9	-0.5	-0.6	-1.0	-1.4	0.6	1.0	1.1
Lung cancer (father)	0.4	0.4	1.2	1.0	0.4	0.4	-0.5	-0.1	-0.3	1.1
Illnesses of mother	0.7	0.8	2.2	1.3	-0.2	-0.1	-1.5	0.3	0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.4	1.6	-0.4	-0.2	-0.1	1.2	0.1	0.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-0.7	0.4	-0.3	1.2	1.0	0.2	-1.1
Impedance of arm (left)	0.2	1.1	2.3	0.9	-1.5	1.2	-0.4	-0.3	-1.2	1.1
Arm fat mass (right)	1.0	4.1	14.1	0.5	2.3	0.5	3.8	0.0	-0.5	-2.9
Trunk predicted mass	1.1	6.4	12.2	3.3	2.9	-2.4	0.9	3.5	2.4	0.7
Standing height	1.0	9.8	26.5	5.2	2.0	-2.0	-0.3	4.3	2.1	3.3
Length of working week for main job	0.4	0.5	1.4	1.0	-1.2	0.2	-0.9	-0.3	-0.1	-0.1
Exposure to tobacco smoke at home	0.3	0.3	1.2	-0.2	-0.9	-0.3	0.1	0.3	0.4	1.1
Breastfed as a baby	0.8	0.9	2.2	0.3	-0.3	-1.0	-1.0	1.0	1.0	1.5
Tense / ‘highly strung’	1.3	2.2	5.0	-0.3	-1.0	2.2	0.4	-1.7	-2.2	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	4.9	7.4	14.7	-0.6	-2.3	3.8	2.2	-3.3	-3.8	-1.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-0.8	0.9	-0.1	0.5	1.5	0.0	1.2
Birth weight of first child	1.1	2.1	8.0	1.2	-0.0	-0.8	-2.8	1.0	0.8	1.7
Peak expiratory flow (PEF)	0.5	1.3	5.4	-0.5	0.6	0.6	2.3	-0.3	-0.6	-1.4
Pulse wave reflection index	1.2	1.4	2.2	-1.5	1.0	-1.4	0.3	0.9	1.3	-1.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	-0.6	0.9	-1.1	0.8	0.8	1.2	-0.8
Loud music exposure frequency	0.1	0.1	0.5	-0.3	-0.7	0.3	0.4	0.1	-0.4	-0.0
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	10.0	1.7	0.9	-1.4	-2.1	1.9	1.4	3.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.5	-0.1	-0.1	0.9	1.6	-0.9	-1.0	-1.5
Blood clot in the leg (DVT)	0.6	0.7	3.3	0.1	0.4	0.5	1.8	-1.1	-0.4	-0.3
Medication: Paracetamol	0.9	1.4	2.4	-1.3	-0.0	1.4	1.5	-1.6	-1.4	-0.2
Headache pain in last month	2.4	4.2	9.2	-0.6	-1.6	3.0	1.1	-2.5	-3.0	-0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.1	0.4	-0.9	1.2	0.2	-1.4	-1.2	0.5
Glaucoma (self-reported)	0.5	0.6	2.0	-1.4	-0.0	0.7	0.0	-1.0	-0.7	-0.7
Gout (self-reported)	0.6	0.8	2.1	-1.1	0.7	-0.9	-0.2	0.6	0.9	-1.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.2	1.6	2.0	-0.6	-0.3	0.7	0.5	2.0
Medication: Amlodipine	0.9	1.2	5.8	-0.6	2.4	-0.3	1.1	0.9	0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.3	-0.7	-0.1	-0.2	-0.0	0.1	-0.6
Birth weight	1.0	2.1	5.0	0.9	-2.2	-0.9	-2.2	1.1	0.9	1.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	5.4	-0.9	-0.7	-0.4	-2.3	0.3	0.3	2.3
High blood pressure (siblings)	2.1	3.0	4.8	-2.0	-0.5	1.6	2.0	-1.6	-1.6	-2.2
Forced vital capacity (FVC), Best measure	0.4	1.5	3.9	2.0	0.8	-0.7	-0.2	1.7	0.7	1.3
Body fat percentage	0.9	3.4	11.7	0.4	0.9	1.5	3.4	-1.0	-1.6	-2.4
Leg fat percentage (right)	1.3	4.6	12.5	-0.3	0.8	2.0	3.5	-1.8	-2.0	-2.8
Arm fat-free mass (right)	0.7	3.4	7.0	2.1	2.6	-1.5	1.6	2.3	1.5	0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.7	1.0	-1.3	0.6	-0.1	-0.2	-0.5	-0.6
Comparative body size at age 10	1.0	2.8	5.6	-1.6	-1.2	1.6	1.9	-1.4	-1.6	-2.4
Number of full brothers	0.2	0.2	0.9	-0.1	-0.2	-0.5	-0.9	0.3	0.5	0.2
Worry too long after embarrassment	0.3	0.4	0.7	0.6	0.9	-0.7	-0.6	0.7	0.6	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	5.8	-1.5	-2.3	2.4	0.3	-2.4	-2.4	-0.2
Wheeze or whistling in the chest in last year	0.6	1.1	1.9	-0.1	-0.6	1.4	1.4	-0.9	-1.3	-1.1
Number of children fathered	0.9	1.0	3.5	1.9	-0.2	-0.2	-1.1	0.2	0.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.7	-1.3	-1.5	1.6	-0.6	-1.9	-1.5	-0.7
Age at first live birth	0.9	1.6	3.8	0.5	1.9	-1.0	-0.2	1.6	1.0	1.6
Pulse wave peak to peak time	0.6	0.7	1.7	1.3	-0.2	0.1	-1.1	-0.6	-0.1	1.2
Health satisfaction	0.8	1.1	3.3	0.0	0.7	0.5	1.8	-1.1	-0.6	-1.4
Shortness of breath walking on level ground	0.7	0.9	1.9	1.4	0.0	1.0	0.7	-0.9	-1.1	0.7
Qualifications: College or University degree	0.0	0.1	0.6	-0.3	0.3	0.3	0.3	0.1	-0.3	-0.8
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.3	-0.1	-0.4	0.5	0.2	0.5	-0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.7	-0.6	0.6	1.3	1.9	-1.5	-1.3	-0.8
Emphysema/chronic bronchitis	1.6	1.8	3.9	-0.9	-0.6	2.0	0.9	-1.5	-1.9	-0.9
Medication for pain relief, constipation, heartburn	2.1	3.5	9.1	2.1	0.2	-1.4	-3.0	1.6	1.4	2.2
Neck or shoulder pain in last month	0.3	0.4	1.6	1.3	-0.8	0.1	-0.4	-0.2	-0.1	0.5
Medication: Blood pressure	0.9	1.6	3.3	-0.1	1.8	-1.6	0.4	1.7	1.6	0.0
Angina (self-reported)	0.4	0.5	1.6	0.1	-0.9	0.3	-1.2	0.2	-0.3	0.9
Migraine (self-reported)	1.8	2.2	4.9	-0.7	0.3	2.1	1.6	-1.7	-2.2	-0.3
Medication: Ibuprofen	1.6	1.9	4.4	-2.1	0.3	1.0	0.9	-1.7	-0.9	-1.8
Medication: Allopurinol	0.6	0.8	1.7	-1.0	-0.5	-1.0	-0.3	0.8	0.9	-1.3
Medication: Omeprazole	1.5	1.8	7.6	0.8	-0.1	0.9	2.8	-0.2	-1.0	-1.5
Medication: Seretide 50 evohaler	0.3	0.3	1.4	0.2	0.6	0.2	1.2	0.6	-0.2	-0.2
Mean time to correctly identify matches	1.3	2.6	4.4	-1.5	-1.8	2.0	0.4	-1.3	-2.1	-1.5
Heart disease (mother)	0.5	0.7	2.9	0.1	-0.6	-0.5	1.7	0.7	0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	2.3	0.6	1.2	-1.5	0.8	1.5	1.5	0.4
Whole body fat mass	0.8	3.2	12.3	0.9	1.6	0.9	3.5	-0.1	-0.9	-2.1
Leg fat mass (right)	0.9	3.4	11.8	0.4	1.5	1.1	3.4	-0.6	-1.1	-2.6
Arm predicted mass (right)	0.7	3.7	7.5	2.4	2.7	-1.6	1.4	2.5	1.6	0.3
Pulse rate, automated reading	0.2	0.8	1.7	-1.0	-0.3	1.0	-0.9	-1.3	-0.9	-0.2
Alcohol intake frequency.	0.3	0.6	1.5	1.0	0.5	0.8	1.2	-0.1	-0.8	0.1
Comparative height size at age 10	0.5	2.6	7.2	2.7	0.3	-1.4	0.4	2.4	1.5	0.9
Number of full sisters	1.8	2.2	5.3	2.3	-0.6	-1.7	-1.3	1.6	1.6	0.5
Suffer from ‘nerves’	0.7	1.1	2.2	0.2	-0.7	1.5	0.8	-1.2	-1.5	-0.7
Overall health rating	0.8	1.8	3.8	-0.7	-0.0	1.6	1.6	-0.9	-1.6	-1.9
Chest pain or discomfort	1.1	1.6	7.6	-1.0	1.2	0.2	2.8	0.2	-0.1	-1.2
Had major operations	0.2	0.3	0.6	0.1	0.2	-0.7	-0.6	0.1	0.7	-0.8
Age at last live birth	0.2	0.3	1.0	0.3	1.0	-0.6	0.0	0.6	0.6	0.4
Family relationship satisfaction	0.6	0.7	3.1	0.5	-1.8	0.5	-0.2	-0.7	-0.6	-0.8
Leg pain on walking	0.3	0.4	0.9	-0.6	-0.2	0.1	0.8	-1.0	-0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	5.6	-1.2	-1.8	1.7	-0.9	-2.4	-1.6	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	0.7	1.0	0.1	0.3	0.1	-0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	-0.7	1.5	-0.9	0.2	0.6	0.8	-0.4
Medication: Aspirin	0.3	0.3	1.5	-1.2	-0.2	0.2	0.6	-0.4	-0.2	-0.5
Supplements: Vitamin C	1.0	1.2	2.0	0.6	-1.3	1.4	-0.5	-0.6	-1.4	1.3
Knee pain experienced in last month	0.9	1.3	4.1	-0.1	-2.0	0.9	0.4	-1.5	-0.9	-1.0
Hypertension (Self-reported)	0.4	1.1	4.0	-0.9	1.0	-0.1	2.0	0.7	0.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.2	0.7	1.1	-0.9	1.1	1.1	0.8	-1.0
Illnesses of father: Heart disease	1.4	1.9	3.1	-1.1	0.2	1.7	1.6	-1.0	-1.7	-1.8
Illnesses of siblings: Diabetes	1.9	2.3	3.8	1.9	1.7	-1.7	-0.1	1.9	1.7	0.6
Smoking status: Previous	0.3	0.4	1.6	-0.2	0.4	-0.3	1.2	0.2	0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.7	1.5	0.4	-1.1	-0.9	1.9	1.2	1.2
Whole body fat-free mass	0.8	4.8	8.4	2.7	2.9	-1.8	1.6	2.9	1.9	0.0
Leg fat-free mass (right)	0.6	3.5	7.1	1.9	2.7	-1.2	2.2	2.1	1.3	-0.9
Arm fat percentage (left)	1.4	5.5	15.8	-0.2	1.1	1.8	4.0	-1.4	-1.8	-3.5
Average weekly red wine intake	1.2	1.8	3.5	0.2	-0.4	-1.8	-1.9	1.3	1.9	0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	1.2	-0.8	0.5	0.3	0.7	-0.6	-0.4
Mood swings	1.8	3.3	6.6	0.2	-1.2	2.6	1.9	-2.1	-2.6	-0.9
Loneliness, isolation	0.9	1.2	7.9	0.1	-2.8	0.2	-0.6	-0.2	-0.2	-0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.8	0.1	-0.2	0.0	0.9	-0.4	-0.0	-0.3
Ever had bowel cancer screening	0.6	0.7	1.2	-0.5	-1.0	-1.1	-1.0	0.6	1.1	-0.6
Diabetes diagnosed by doctor	0.2	0.4	0.8	0.9	-0.2	0.5	0.8	-0.0	-0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.3	0.1	-0.1	-0.3	-0.1	0.1	-0.1
Friendships satisfaction	0.3	0.4	2.1	1.5	-0.3	0.0	-0.0	0.7	0.0	0.0
Qualifications: nursing, teaching	0.3	0.5	2.3	0.1	-1.2	-0.0	-1.5	0.2	0.0	0.0
Commuting to job workplace: Walk	0.6	0.6	2.5	0.4	-0.7	0.7	1.6	-0.1	-0.7	0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.0	0.6	-0.4	-0.4	0.1	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	0.0	0.0	0.9	1.4	-0.9	-0.9	-1.1
Medication for cholesterol	1.9	2.8	6.2	1.7	0.5	-1.6	-2.5	1.4	1.6	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-0.2	0.5	0.5	1.0	0.1	-0.6	-0.8
Back pain experienced in last month	0.5	0.7	2.3	-0.2	-1.1	-0.6	-1.5	0.6	0.6	0.1
Mineral and other dietary supplements	0.4	0.6	1.7	0.4	1.3	-0.3	-0.8	0.7	0.2	0.9
Breast cancer (self-reported)	0.2	0.3	1.0	-1.0	0.0	-0.2	-0.6	-0.1	0.2	-0.6
Asthma (self-reported)	0.1	0.2	0.5	-0.1	0.1	0.5	0.7	-0.5	-0.4	-0.2
Osteoporosis (self-reported)	0.5	0.7	3.4	0.7	-0.4	-0.5	-0.2	0.3	0.5	1.8
Osteoarthritis (self-reported)	1.8	2.3	6.1	0.2	2.5	-2.0	0.6	1.1	1.9	-1.0
Medication: Aspirin	0.5	0.6	2.1	-1.5	0.0	0.3	1.0	-0.4	-0.3	-1.0
Medication: Gliclazide	0.4	0.4	1.8	0.5	0.3	-0.4	1.3	0.6	0.4	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	-0.1	-0.0	-0.3	-0.8	0.1	0.3	0.9
Smoking status: Current	0.3	0.5	1.5	-0.4	-1.2	0.3	0.4	0.0	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.0	1.4	0.5	0.0	0.7	0.3	-0.1	-1.1
Whole body water mass	0.8	4.7	8.6	2.6	2.9	-1.8	1.6	2.8	1.9	-0.1
Leg predicted mass (right)	0.6	3.4	6.8	1.9	2.6	-1.3	2.1	2.2	1.3	-0.8
Arm fat mass (left)	0.9	3.8	13.7	0.6	1.8	0.7	3.7	-0.1	-0.7	-2.9
Number of self-reported non-cancer illnesses	0.6	1.1	4.3	0.6	2.1	-0.7	0.8	1.1	0.7	0.2
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.1	0.7	0.8	0.1	-0.9	-0.8	-0.5
Miserableness	0.9	1.6	3.6	0.0	-0.3	1.4	1.9	-1.2	-1.4	-1.5
Guilty feelings	1.6	2.3	4.5	0.5	-1.3	2.1	1.3	-1.9	-2.1	-0.3
Wears glasses or contact lenses	2.0	2.3	5.7	-1.2	1.4	1.2	2.4	-1.6	-1.3	-1.2
Ever taken oral contraceptive pill	0.8	0.8	2.1	-0.7	-0.5	-1.1	-1.4	0.0	1.1	0.9
Hearing aid user	0.6	0.6	1.2	0.2	0.6	-1.1	0.5	0.9	1.1	0.8
Mother’s age at death	1.8	2.3	3.8	-1.2	-1.2	1.9	1.6	-1.5	-1.9	-0.8
Financial situation satisfaction	0.5	0.6	1.8	-0.2	1.0	0.6	1.3	-0.8	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.9	0.2	-0.2	0.9	-0.3	0.2	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.5	-0.6	-0.6	0.6	0.7	-0.3	-0.6	-0.2
Eye problems/disorders: Glaucoma	1.1	1.3	2.3	-1.5	-0.4	1.4	0.1	-1.3	-1.5	-0.9
Medication: Blood pressure	1.4	2.6	8.8	-1.2	-1.0	1.1	2.0	-0.7	-1.1	-3.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.1	-0.3	0.3	-0.6	-0.3	-0.3	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.2	-1.2	-0.5	-0.7	0.0	0.6	0.1
High cholesterol (Self-reported)	0.4	0.7	2.1	-1.4	1.2	0.2	1.0	0.0	-0.2	0.1
Medication: Bendroflumethiazide	0.4	0.6	1.8	0.7	0.7	-0.3	1.3	0.9	0.4	-0.6
Medication: Paracetamol	0.9	1.4	2.5	-1.0	-0.2	1.4	1.6	-1.6	-1.4	-0.6
Medication: Lisinopril	0.2	0.3	1.6	0.2	-0.4	-0.0	-0.3	-0.2	-0.0	1.3
Medication: Atorvastatin	1.2	1.5	3.0	0.1	1.3	-1.7	-0.5	1.6	1.7	0.4
Illnesses of father: High blood pressure	0.7	0.9	3.1	-1.1	0.9	-0.2	1.8	-0.2	0.2	-1.0
Alcohol drinker status: Never	1.9	2.3	4.4	0.9	-0.3	-2.1	-1.2	2.1	2.1	0.8
Ever smoked	0.7	1.3	4.5	-0.9	-0.8	0.2	1.6	-0.6	-0.1	-2.1
Basal metabolic rate	0.7	4.1	8.1	2.5	2.8	-1.4	2.1	2.5	1.5	-0.5
Leg fat percentage (left)	1.0	3.8	12.0	-0.1	1.1	1.6	3.5	-1.4	-1.6	-2.5
Arm fat-free mass (left)	0.9	4.5	9.4	2.2	3.1	-1.9	1.4	2.8	2.0	0.2
Number of operations (self-reported)	0.6	0.8	3.2	-1.1	0.3	0.3	0.5	-0.9	-0.3	-1.8
Average weekly beer plus cider intake	0.8	1.2	3.2	-1.3	0.4	1.0	-0.7	-1.8	-1.0	0.8
Irritability	0.4	0.7	1.8	1.0	1.0	-0.6	1.3	0.3	0.6	-0.9
Risk taking	0.7	1.0	2.2	-0.0	-1.5	1.2	0.1	-1.2	-1.1	-1.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	0.1	0.6	-0.5	0.0	0.8	0.4	-1.2
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.3	-0.3	-1.1	-0.9	0.1	1.1	-0.2
Age started oral contraceptive pill	0.8	1.1	2.0	-1.2	-0.7	1.3	-0.1	-1.4	-1.3	-0.5
Diastolic blood pressure, automated reading	0.5	1.5	4.0	-1.3	0.8	1.2	2.0	-0.5	-1.2	-1.2
Ever depressed for a whole week	1.3	1.6	2.8	1.5	-0.2	1.4	1.7	-0.7	-1.4	-1.2
Unable to work because of sickness or disability	0.2	0.3	0.8	0.9	-0.9	0.4	0.3	-0.4	-0.4	0.0
Commuting to job workplace: Cycle	1.6	1.9	3.2	0.1	-0.8	1.8	-0.7	-1.8	-1.8	1.6
Myopia	0.9	1.3	4.6	-1.0	2.1	-1.1	1.1	0.6	1.0	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.7	1.4	-0.7	-0.4	-2.2	-0.1	0.4	1.3
Cholesterol lowering medication	1.1	1.6	3.3	-1.6	0.3	1.2	1.8	-1.2	-1.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	7.9	1.0	-0.1	0.7	2.8	-0.5	-0.8	-1.9
Pain experienced in last month	0.4	0.7	1.5	-0.5	1.2	-0.9	0.5	1.0	0.9	-0.7
Supplements: Calcium	0.4	0.4	1.2	1.1	0.6	0.2	0.7	0.8	-0.2	0.4
Basal cell carcinoma (self-reported)	0.7	0.8	1.7	-0.5	-0.7	-1.1	-0.0	1.3	1.1	-1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.2	-0.9	-0.6	-0.2	0.5	0.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.0	-0.1	0.4	0.4	1.7	-1.2	-0.4	-0.1
Heart disease (siblings)	1.8	2.2	5.3	0.4	1.2	-1.9	0.2	2.3	1.9	1.1
Alcohol drinker status: Previous	1.2	1.4	4.9	-1.1	2.2	0.6	1.1	-0.3	-0.5	-1.2
Pack years of smoking	0.2	0.3	0.9	-0.5	-0.2	-0.7	0.3	0.2	0.7	-0.9
Impedance of whole body	0.4	1.8	4.7	0.5	-1.9	0.9	-1.5	-0.3	-1.0	2.2
Leg fat mass (left)	0.8	3.0	11.0	0.6	1.7	0.7	3.3	-0.2	-0.7	-2.4
Arm predicted mass (left)	0.8	4.2	8.9	2.2	3.0	-1.8	1.2	2.7	1.8	0.2