Hub : Genes

CMPK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0260	2.3e-06	0.080	0.053	0.061	0.061	0.069	4.9e-10	4.0e-07	6.2e-08	6.2e-08	9.0e-09
2	GTEx	Adipose Visceral Omentum	0.1130	0.0430	1.7e-03	0.118	NA	0.085	NA	0.104	1.1e-06	NA	3.5e-05	NA	4.6e-06
3	GTEx	Artery Aorta	0.1780	0.0450	1.9e-06	0.207	NA	0.185	NA	0.196	1.2e-11	NA	1.9e-10	NA	5.0e-11
4	GTEx	Colon Transverse	0.2430	0.0680	1.7e-05	0.204	NA	0.219	NA	0.196	5.0e-10	NA	1.0e-10	NA	1.1e-09
5	GTEx	Nerve Tibial	0.0931	0.0371	1.9e-03	0.062	NA	0.059	NA	0.045	3.5e-05	NA	5.5e-05	NA	3.6e-04
6	ROSMAP	Brain Pre-frontal Cortex	0.0993	0.0285	3.1e-07	0.066	0.047	0.066	0.053	0.060	7.6e-09	9.7e-07	6.7e-09	1.9e-07	3.3e-08
7	YFS	Blood	0.1190	0.0252	0.0e+00	0.112	0.106	0.120	0.127	0.115	9.5e-35	1.0e-32	3.6e-37	2.2e-39	1.4e-35
8	TCGA	Breast Invasive Carcinoma	0.0154	0.0108	3.5e-03	0.006	0.010	0.010	NA	0.008	1.8e-02	3.3e-03	2.5e-03	NA	6.5e-03
9	TCGA	Esophageal Carcinoma	0.1170	0.0710	5.6e-03	0.141	0.074	0.093	NA	0.126	3.0e-05	2.3e-03	6.9e-04	NA	8.3e-05
10	TCGA	Stomach Adenocarcinoma	0.0820	0.0410	3.4e-04	0.008	0.028	0.009	NA	0.020	7.7e-02	4.2e-03	6.9e-02	NA	1.3e-02
11	TCGA	Thyroid Carcinoma	0.0640	0.0380	1.7e-05	0.027	0.055	0.043	NA	0.022	1.1e-03	4.1e-06	5.1e-05	NA	3.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.1	0.4	-0.2	0.6	0.1	-0.3	0.2	0.1	-0.5	-0.5	-0.2	-0.1	-0.5
Bipolar Disorder or Schizophrenia	0.6	1.5	2.2	-1.3	1.2	1.4	-1.5	1.4	0.8	-1.5	-1.3	1.1	0.5	-0.9
Depressed Affect (Nagel 2018)	0.3	0.5	1.2	-1.0	0.8	0.8	-0.2	1.1	0.9	-0.1	-0.5	-0.9	0.2	-0.7
Depression (Nagel 2018)	0.3	0.4	1.1	-0.3	0.9	0.6	-0.2	1.0	0.3	0.7	-0.8	-0.8	0.1	-0.4
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.9	-0.7	-0.0	-1.1	0.0	-0.7	-2.6	-0.1	0.3	-2.2	-2.1	-1.1
Neuroticism (Nagel 2018)	0.8	2.0	6.6	-1.8	0.7	1.8	-1.3	2.6	0.2	-1.5	-0.8	-0.9	-0.5	-1.6
Schizophrenia (2018)	0.9	1.8	3.1	-1.5	1.1	1.8	-1.6	1.6	0.9	-1.5	-1.3	1.5	0.7	-0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	3.5	-0.1	0.1	0.9	-0.6	1.0	1.3	-0.2	-0.4	1.9	1.5	0.3
Worry (Nagel 2018)	1.2	2.5	6.0	-1.5	1.2	1.8	-2.0	2.4	-0.7	-2.2	-1.1	-0.3	-0.6	-1.8
Alzheimer’s Disease (in mother)	1.2	1.5	3.4	0.5	-0.9	-1.8	1.8	-0.9	-1.0	1.4	0.6	-1.8	-1.0	0.7
Alzheimer’s Disease (in father)	0.5	0.6	1.7	-0.1	0.9	0.2	-0.2	1.3	-1.3	-0.2	-1.0	-0.6	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	6.0	-0.5	0.1	-0.6	0.3	0.7	-1.7	0.3	-0.7	-2.5	-1.7	-0.8
Crohns Disease (2017)	0.7	1.5	3.0	-1.7	1.3	1.7	-1.4	0.9	-0.3	-1.5	-1.4	0.2	0.4	-1.4
Irritable Bowel Disease (IBD)	1.2	2.9	5.4	-2.3	2.0	2.0	-1.9	0.5	-1.6	-1.7	-2.1	-0.4	-0.1	-2.2
Ulcerative Colitis (UC)	1.0	1.9	3.3	-1.7	1.6	1.6	-1.7	0.2	-1.6	-1.0	-1.8	-0.1	0.0	-1.7
Major Depression (MDD)	0.8	1.0	3.9	-0.8	2.0	0.6	-0.8	-0.0	-0.4	-0.7	-1.8	0.1	0.3	-1.1
Reaction Time	0.1	0.2	0.5	0.2	0.6	0.3	-0.7	-0.1	-0.6	0.1	-0.4	0.5	0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.9	-0.3	0.3	-1.0	0.4	-1.0	-1.7	0.2	-0.0	-0.8	-0.7	-0.4
Breast Cancer	0.9	2.2	4.5	-1.6	1.5	1.2	-1.4	0.9	-1.6	-0.7	-1.4	-2.1	-1.4	-2.1
Ovarian Cancer	0.5	0.7	2.5	0.7	0.1	-0.6	0.7	0.1	1.1	0.7	0.1	1.1	1.6	1.1
Prostate Cancer	2.6	3.7	7.1	-2.3	1.9	2.7	-2.3	2.6	-0.6	-1.8	-2.2	0.2	0.2	-2.1
Age at First Birth	0.8	1.1	2.1	-1.2	0.9	1.3	-1.0	-0.3	0.9	-1.3	-1.0	1.1	1.5	-0.5
Bipolar Disorder (2011)	0.8	0.8	3.2	0.1	0.9	0.5	-0.4	0.5	1.4	-0.3	-0.8	1.2	1.8	0.1
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	-1.0	0.2	-0.2	-0.2	-0.2	-1.5	-0.1	0.1	-1.4	-1.4	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.8	0.9	0.3	-0.9	0.7	-1.3	-0.9	-0.9	0.2	-0.4	-1.0
Crohns Disease (2012)	0.3	0.5	2.2	-0.7	0.2	1.1	-0.6	0.3	0.4	-0.9	-0.5	1.5	0.7	-0.3
Mean Putamen Volume	2.7	3.1	6.0	-2.5	0.3	1.6	-1.4	1.7	-1.0	-2.0	-1.2	-2.0	-2.2	-2.3
Fasting Glucose	0.2	0.2	0.7	0.2	-0.4	-0.1	-0.5	0.7	0.1	-0.5	0.6	0.9	0.5	0.2
HbA1C	0.5	0.6	1.4	1.1	-0.2	-0.7	0.6	-0.4	0.5	1.2	0.9	0.1	0.9	0.7
HDL Cholesterol	0.6	1.0	2.2	-0.9	1.2	1.3	-1.1	1.3	0.5	-1.5	-1.0	0.5	0.1	-1.0
LDL Cholesterol	1.0	1.6	4.0	1.4	-1.4	-1.4	1.7	-2.0	0.0	1.0	1.4	0.5	0.1	1.3
Lupus	1.8	2.8	5.9	2.3	-1.5	-2.1	2.1	-1.5	0.8	2.4	1.4	0.4	0.5	1.8
Neuroticism (2016)	0.4	0.6	1.3	0.5	-0.9	-1.0	1.2	-0.1	0.9	0.8	0.9	-0.8	-0.4	0.6
Primary Biliary Cirrhosis	0.2	0.2	0.9	-0.3	-0.4	-0.2	-0.3	-0.1	-1.0	-0.5	0.1	-0.1	-0.9	-0.3
Rheumatoid Arthritis	0.3	0.5	1.8	0.8	0.4	-0.3	-0.5	-0.1	0.2	0.7	-0.1	1.3	1.1	0.5
Schizophrenia (2014)	0.7	1.6	3.3	-1.2	0.6	1.5	-1.5	1.6	0.8	-1.4	-1.0	1.8	0.8	-0.7
Triglycerides	0.8	1.3	3.6	1.1	-0.9	-0.9	1.5	-1.9	0.8	1.7	1.0	-0.5	0.3	1.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.9	-0.1	0.2	0.0	0.5	-0.1	1.0	0.1	-0.1	0.1	0.1	0.1
Ulcerative Colitis	0.4	0.6	2.7	-0.3	0.1	-0.2	0.1	-0.9	-1.6	-0.0	-0.1	-1.4	-0.9	-0.5
Blood Eosinophil Count	1.0	7.5	13.0	1.2	-3.0	-3.4	3.0	-3.5	-1.5	2.2	2.7	-3.6	-3.3	1.2
Blood Platelet Count	0.8	9.6	28.4	1.1	-2.1	-3.3	1.8	-2.6	-5.3	1.4	2.7	-4.3	-4.7	-0.1
Blood Red Count	1.7	16.8	50.6	-1.7	-3.8	-3.3	1.5	-4.1	-5.5	-0.1	2.2	-7.1	-7.1	-1.0
Blood White Count	0.0	0.2	1.1	-0.2	-0.5	1.1	-0.6	-0.3	-0.3	0.6	0.0	0.0	-0.1	-0.2
Heel T-Score	0.6	4.4	8.4	-2.3	2.4	2.8	-2.9	1.7	-0.8	-2.8	-1.8	1.0	1.1	-2.2
BMI	0.7	4.0	8.6	0.6	-1.0	-2.5	2.4	-2.3	-2.9	1.8	1.2	-2.9	-1.9	0.5
Height	2.0	38.8	83.5	-7.1	9.1	5.3	-6.3	4.0	-4.8	-6.1	-8.6	-1.8	-2.7	-8.1
Waist Hip Ratio (WHR)	0.4	1.7	5.6	1.1	-0.2	0.2	0.3	-0.7	1.8	1.1	-0.1	2.4	2.1	1.4
Systolic Blood Pressure	1.3	6.5	12.5	-3.2	2.9	2.3	-2.2	2.0	-2.3	-2.6	-3.5	-1.2	-1.6	-3.1
Smoking Status	0.3	0.6	1.9	-0.4	0.7	-0.5	-0.1	0.1	-1.1	0.3	-0.6	-1.4	-1.3	-0.7
Allergy or Eczema	0.5	1.4	3.3	1.6	-1.0	-1.5	1.1	-1.8	0.4	0.4	1.3	0.8	0.4	1.4
Cardiovascular Disease	0.9	2.9	9.2	-1.4	3.0	2.2	-1.5	0.8	0.4	-1.1	-2.6	0.8	1.2	-1.5
Hypothyroidism (self reported)	0.3	0.7	1.7	1.2	0.1	-0.8	0.8	-0.5	1.3	0.8	0.4	0.6	0.9	1.0
Respiratory disease	1.1	2.5	7.5	-1.3	2.7	1.6	-1.7	1.5	-0.2	-1.4	-2.4	0.8	0.9	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.8	-0.6	1.7	1.2	-0.9	0.5	0.4	-0.7	-1.4	0.8	1.2	-0.7
Lung FEV1/FVC ratio	0.2	0.8	4.3	-0.2	-0.5	-0.8	0.5	-0.5	-0.6	0.9	0.6	-2.1	-1.2	-0.1
Lung FVC	0.6	3.0	9.2	-1.2	3.0	2.0	-1.5	1.8	-0.5	-0.3	-2.9	0.8	1.2	-1.5
Neuroticism	0.8	2.0	7.4	-1.5	1.1	1.8	-1.4	2.7	0.0	-1.2	-1.2	-0.7	-0.6	-1.6
Chronotype (morning person)	0.4	0.9	2.9	1.2	0.4	-0.4	0.5	-0.8	0.7	0.8	-0.2	1.3	1.7	1.1
Hair Pigment	0.0	0.6	1.5	0.2	-1.2	0.8	0.5	1.2	0.7	-0.0	0.7	-1.2	0.0	0.3
Tanning	0.1	0.7	1.8	0.6	-1.4	-1.1	1.4	-0.2	0.6	0.3	1.1	-0.2	-0.5	0.9
Hand grip strength (left)	1.6	4.1	14.1	-1.7	2.6	0.8	-2.1	0.0	-3.8	-1.2	-2.2	-1.1	-1.7	-2.6
Number of treatments/medications taken	0.1	0.1	0.5	0.7	0.7	-0.1	-0.1	0.1	-0.0	0.5	-0.1	0.3	0.2	0.1
Average weekly spirits intake	3.2	3.9	7.3	2.2	-2.6	-2.3	2.1	-1.9	0.5	2.7	2.2	-0.7	-0.4	2.3
Sensitivity / hurt feelings	0.6	1.0	3.0	-0.0	1.0	1.1	-0.2	1.1	1.7	0.2	-0.6	1.0	1.6	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.6	0.2	0.4	-0.1	1.0	-0.2	0.4	-0.3	-0.9	-0.3	-0.5
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-1.0	0.8	0.2	-0.1	0.9	-0.5	-0.4	-0.9	-0.7	-0.6	-1.0
Relative age of first facial hair	0.4	0.8	2.5	0.4	-1.1	-0.9	0.9	-0.4	-0.4	0.9	1.1	-1.6	-1.1	0.2
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	7.8	-2.0	2.8	1.9	-1.9	1.6	-1.2	-2.0	-2.5	-0.3	-0.3	-2.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	0.9	-0.9	-0.8	0.9	-0.7	0.7	0.7	0.7	0.4	0.5	1.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	-0.0	-0.5	-0.5	0.2	0.2	-0.9	-0.4	0.6	-0.9	-0.8	-0.1
Systolic blood pressure, automated reading	1.0	3.0	4.9	-2.2	1.5	1.3	-1.1	1.4	-2.1	-1.6	-2.1	-1.4	-1.9	-2.2
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.2	-0.3	1.9	1.6	-2.0	0.8	0.7	-0.6	-1.3	1.4	1.8	-0.8
Angina	0.7	0.9	2.6	1.1	0.7	-0.3	0.4	0.1	1.6	0.3	-0.1	1.3	1.6	0.9
Medication for hormone replacement therapy	0.3	0.3	1.2	0.7	-0.1	0.1	0.0	1.1	0.2	0.6	0.1	0.6	1.0	0.4
Vitamin and mineral supplements	0.1	0.2	0.4	-0.1	-0.5	-0.0	0.2	-0.4	0.6	0.7	0.3	-0.4	0.1	0.4
Supplements: Zinc	2.2	2.4	6.3	-1.2	2.5	1.7	-1.7	1.7	-0.5	-1.6	-1.9	0.3	0.4	-1.9
Medication: Co-codamol	2.2	2.5	4.2	-1.7	1.2	1.3	-1.9	1.0	-1.9	-1.8	-0.9	-1.5	-1.6	-2.1
Medication: Metformin	0.1	0.1	0.4	-0.4	0.2	0.6	-0.4	-0.3	0.3	-0.6	-0.1	0.2	0.2	-0.4
Diabetes (father)	0.6	0.8	2.5	-0.4	-0.7	-0.3	0.8	-0.7	-1.0	1.0	0.3	-1.6	-1.5	-0.2
Diabetes (mother)	0.6	0.8	2.2	1.5	-0.2	-0.9	0.9	-0.7	-0.0	1.3	0.5	1.0	0.9	0.9
Severe depression (siblings)	0.6	0.7	3.1	-0.3	-0.1	-0.5	0.0	-0.1	-1.8	0.1	0.2	-1.2	-1.4	-0.7
Pack years adult smoking proportion	0.2	0.3	1.5	-0.4	-0.0	0.1	-0.2	-0.1	-0.3	0.5	-0.4	-1.2	-1.2	-0.5
Impedance of leg (right)	0.7	3.4	6.7	-0.4	2.2	1.9	-1.5	1.8	2.5	-0.1	-2.1	2.4	2.6	-0.1
Leg fat-free mass (left)	0.9	4.6	13.5	-2.0	1.2	-0.2	-0.6	-0.4	-3.7	-1.8	-1.1	-3.0	-3.2	-2.6
Trunk fat percentage	0.3	1.1	4.4	-1.0	0.7	-0.2	0.3	-0.5	-1.5	-0.4	-1.0	-2.1	-1.3	-0.9
Hand grip strength (right)	1.8	5.0	10.2	-2.3	3.0	1.0	-2.2	0.8	-3.2	-1.9	-2.8	-1.2	-1.8	-2.9
Townsend deprivation index at recruitment	3.6	5.1	9.1	-2.5	2.7	2.2	-2.5	2.9	-1.1	-2.2	-3.0	1.9	0.8	-2.0
Current tobacco smoking	0.4	0.7	1.9	-0.8	1.3	0.6	-1.0	-0.0	-0.4	0.1	-1.4	-0.8	-0.7	-0.9
Average weekly fortified wine intake	0.3	0.4	1.1	0.2	0.5	-0.9	1.1	0.0	-0.9	0.6	-0.4	-0.7	-0.1	0.2
Maternal smoking around birth	2.3	3.3	6.5	-2.1	1.9	1.9	-2.2	0.8	-1.7	-2.2	-1.8	-1.0	-0.9	-2.5
Fed-up feelings	0.2	0.4	0.9	-0.9	0.4	0.9	-0.4	0.9	-0.1	-0.3	-0.4	-0.4	-0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	0.6	0.4	-0.3	0.9	0.1	1.0	1.1	-0.2	-0.2	0.6	0.4
Relative age voice broke	0.1	0.1	0.5	0.4	-0.1	0.1	0.3	0.3	0.7	0.1	0.3	0.3	0.4	0.4
Taking other prescription medications	0.6	0.9	2.2	-0.7	1.3	1.5	-1.3	1.1	0.4	-0.7	-0.9	0.4	0.1	-1.0
Age when periods started (menarche)	6.4	15.4	24.2	-4.7	4.3	4.8	-4.9	4.3	-2.0	-4.2	-4.3	0.0	-0.4	-4.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	1.0	0.0	-0.0	-0.2	0.1	-0.2	-1.0	-0.1	0.3	-0.4	-0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	0.3	-0.7	-0.9	0.2	-0.7	-1.0	0.1	1.1	-1.2	-1.1	-0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	-0.2	-0.1	-0.5	0.4	-0.3	-1.1	-0.1	-0.2	-1.5	-0.9	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.5	0.4	0.3	-0.5	-0.4	-0.7	-0.2	-0.3	-1.0	-0.5	-0.6
Serious illness, injury or assault to yourself	3.0	3.7	8.1	-2.3	2.9	1.5	-1.8	1.5	-1.8	-2.3	-2.4	-0.4	-0.2	-2.2
High blood pressure	0.3	0.8	1.4	-0.8	1.0	0.8	-0.4	0.6	-1.0	-0.8	-1.1	-0.9	-1.0	-1.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	8.0	1.4	-1.0	-1.5	1.1	-2.8	-0.5	0.6	1.2	0.4	-0.2	1.1
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	-0.3	-0.2	0.4	0.2	0.2	-0.4	0.4	-0.0	-0.4	0.0
Stomach or abdominal pain in last month	2.7	3.4	5.6	-2.1	1.5	2.2	-2.3	2.1	-1.6	-1.7	-1.6	-1.4	-0.9	-2.4
Supplements: Glucosamine	0.9	1.1	3.2	1.3	-1.0	-1.8	1.5	-0.8	0.5	0.6	1.0	-0.7	-0.3	1.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	-0.9	1.2	0.4	-0.2	0.8	-0.4	-0.7	-1.3	-1.1	-0.5	-1.0
Medication: Atenolol	0.1	0.2	0.4	0.4	0.6	-0.2	0.5	-0.0	0.2	0.6	-0.6	-0.3	-0.2	0.3
Medication: Levothyroxine sodium	0.4	0.8	1.4	1.1	-0.6	-1.0	1.1	-0.4	1.2	1.0	0.8	0.3	0.5	1.1
Sitting height	0.3	1.9	4.5	-1.5	2.1	0.8	-1.3	0.9	-1.1	-1.6	-1.6	-0.6	-1.0	-1.9
Chronic bronchitis/emphysema (father)	0.8	1.0	2.6	1.1	-0.1	-0.6	1.3	-0.6	1.6	1.5	0.1	-0.2	0.8	1.2
High blood pressure (mother)	0.4	0.6	3.0	-0.4	0.5	-0.2	0.1	-0.8	-1.7	-0.0	-0.1	-1.0	-1.2	-0.6
Body mass index (BMI)	0.7	2.8	7.0	0.5	-1.2	-1.9	1.8	-2.0	-2.1	1.1	1.1	-2.6	-2.1	0.3
Impedance of leg (left)	1.1	5.6	10.9	-0.7	2.7	2.7	-2.1	2.5	2.9	-0.6	-2.6	3.1	3.3	-0.3
Leg predicted mass (left)	0.9	4.6	13.2	-2.1	1.3	-0.0	-0.7	-0.3	-3.6	-1.9	-1.2	-2.9	-3.2	-2.6
Trunk fat mass	0.5	2.2	5.9	-1.6	1.4	-0.0	-0.1	-0.4	-2.2	-0.9	-1.5	-2.4	-1.8	-1.6
Waist circumference	0.5	1.8	5.7	-0.7	-0.1	-1.0	0.9	-1.1	-2.4	0.1	0.1	-2.3	-2.2	-0.8
Number of incorrect matches in round	1.1	1.9	3.7	1.6	-1.4	0.1	0.6	0.1	1.9	1.3	1.4	1.9	1.5	1.6
Past tobacco smoking	0.8	1.4	4.0	-0.1	-0.2	2.0	-1.5	0.6	1.3	-0.8	-0.1	2.0	1.6	0.1
Alcohol usually taken with meals	0.2	0.3	0.7	0.6	-0.4	-0.8	0.4	-0.2	-0.5	0.1	0.8	-0.6	-0.5	0.4
Nervous feelings	0.6	1.0	1.9	-0.8	1.3	1.0	-0.8	1.4	-0.9	-0.5	-1.3	-1.0	-0.7	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.3	-0.3	-0.7	-0.3	-0.3	0.2	-1.4	0.1	0.6	-0.9	-1.5	-0.6
Hearing difficulty/problems with background noise	1.6	2.6	5.4	-2.0	1.9	1.9	-1.6	1.7	-0.8	-1.2	-2.3	-0.2	-0.1	-1.9
Hair/balding pattern: Pattern 2	0.2	0.2	1.0	-0.1	-0.2	0.4	0.0	0.5	0.3	-0.6	0.0	-1.0	-0.5	-0.2
Had menopause	0.4	0.6	1.3	0.9	-0.7	-0.9	1.1	-0.4	0.4	1.0	0.6	0.4	0.3	0.9
Had other major operations	0.9	1.1	3.2	1.2	-0.1	-1.7	1.8	-1.1	0.3	1.1	0.7	-0.9	0.1	0.9
Forced vital capacity (FVC)	1.5	5.9	15.2	-2.3	3.9	2.5	-2.7	1.9	-1.2	-1.8	-3.9	0.9	0.7	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.7	-0.8	1.2	0.5	-1.0	0.7	-0.6	-1.3	-0.7	-0.8	-0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	-0.9	0.8	0.5	-1.0	0.9	-1.5	-1.1	-0.7	-0.7	-0.9	-1.1
Qualifications: None of the above	0.3	0.6	1.3	-0.2	1.1	0.4	-0.1	0.7	-0.9	1.1	-1.1	-0.9	-0.5	-0.9
Financial difficulties in last 2 years	0.3	0.4	1.5	0.1	1.2	0.3	-0.3	1.1	-0.0	0.2	-0.9	-0.3	0.2	-0.3
Mouth/teeth dental problems	0.1	0.1	0.4	-0.1	-0.3	-0.3	0.3	-0.0	0.6	-0.6	0.3	0.1	0.5	0.3
Heart attack	1.0	1.2	3.8	-1.2	0.6	0.3	-0.9	1.1	-1.0	-0.7	-0.7	-2.0	-1.5	-1.3
Allergy	0.4	0.9	2.4	-1.2	-0.5	0.6	-0.7	1.2	-0.6	-0.8	-0.0	-1.5	-1.4	-1.0
Pain all over the body in last month	1.6	1.7	6.8	0.3	1.0	0.5	0.5	-0.2	1.5	0.0	-1.0	2.6	2.6	0.8
Diabetes (self-reported)	0.5	0.8	2.8	0.1	1.7	0.7	-0.6	-0.1	0.2	-0.0	-1.1	1.4	1.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.4	0.3	0.4	-0.9	0.4	-1.6	-1.2	0.3	0.0	-0.8	-0.5	0.0
Medication: Ramipril	1.6	2.1	6.6	-1.1	1.4	0.5	-0.8	0.9	-2.6	-0.7	-1.6	-1.5	-1.9	-1.7
Medication: Simvastatin	0.4	0.5	1.5	0.6	0.3	-0.1	0.5	-0.7	1.2	1.0	-0.3	0.6	1.1	0.8
Fluid intelligence score	0.6	1.3	3.7	-1.3	1.9	0.7	-1.0	0.1	-1.4	-1.0	-1.4	-0.3	0.1	-1.4
Illnesses of siblings	0.6	0.8	2.3	0.9	-0.7	-1.5	1.3	-1.0	0.6	0.7	0.9	-0.6	-0.5	0.8
Neuroticism score	0.7	1.5	4.4	-1.3	1.1	1.5	-1.1	2.1	-0.3	-0.8	-1.1	-1.1	-0.6	-1.4
Weight	0.7	3.3	9.9	-1.7	1.5	-0.1	-0.3	-0.4	-3.1	-1.1	-1.4	-2.7	-2.5	-2.1
Impedance of arm (right)	0.9	4.4	8.1	-2.4	2.4	2.5	-2.5	2.7	0.0	-2.0	-2.9	0.2	0.2	-2.1
Arm fat percentage (right)	0.5	2.0	7.0	-0.7	-0.2	-0.9	0.7	-1.3	-2.5	0.1	-0.2	-2.6	-2.1	-0.7
Trunk fat-free mass	0.8	4.7	9.6	-2.4	2.8	1.1	-1.7	0.9	-2.7	-2.3	-2.3	-1.4	-2.0	-3.1
Hip circumference	1.2	5.0	14.4	-2.0	1.1	-0.4	-0.3	-0.1	-3.8	-1.4	-0.9	-3.7	-3.5	-2.5
Time employed in main current job	0.8	0.9	2.1	-0.6	0.7	1.5	-1.0	1.4	0.4	-0.8	-0.4	1.0	1.3	-0.9
Alcohol intake versus 10 years previously	1.6	2.3	5.9	-1.7	0.8	0.3	-0.8	0.1	-2.4	-1.4	-0.9	-2.0	-2.3	-1.9
Father’s age at death	0.9	1.3	2.9	-1.4	-0.4	0.7	-0.4	1.6	0.1	-1.4	-0.8	-1.5	-1.7	-0.8
Worrier / anxious feelings	1.3	2.4	6.8	-1.2	0.9	2.2	-2.3	2.6	-0.2	-2.0	-0.6	0.0	-0.2	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	-0.4	1.0	0.9	-1.1	0.6	-0.2	-0.4	-1.0	0.2	0.0	-0.9
Falls in the last year	5.7	7.7	12.6	3.2	-3.0	-3.3	3.6	-2.9	2.4	2.2	3.3	-0.1	0.4	3.5
Hair/balding pattern: Pattern 3	0.7	1.0	3.2	-0.8	1.7	0.7	-0.8	0.9	-0.5	-0.4	-1.8	1.0	0.6	-0.8
Number of live births	0.3	0.5	1.1	0.5	-0.4	-0.8	0.5	-1.0	-0.4	1.0	0.6	-0.9	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	8.0	-1.8	2.8	2.0	-2.4	1.2	-1.0	-1.1	-2.8	0.5	0.4	-2.0
Pulse rate	0.1	0.2	0.4	0.5	-0.2	-0.4	0.6	0.4	0.6	0.4	-0.1	0.1	0.2	0.5
Happiness	0.4	0.5	2.1	0.0	1.0	-0.0	-0.3	0.0	-1.5	0.6	-0.5	-0.8	-0.5	-0.6
Noisy workplace	5.6	6.9	11.0	3.3	-3.0	-3.2	3.0	-2.7	0.5	3.2	3.2	0.0	0.4	3.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.4	0.0	-1.1	-0.2	0.1	0.7	0.3	-1.2	1.0	0.4	0.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.4	-0.8	1.1	0.5	-0.3	-0.3	-0.8	-0.6	-1.1	-1.6	-0.9	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	1.2	0.6	0.8	-0.5	0.2	0.2	-0.2	1.1	-0.5	0.8	0.4	0.4
Asthma	0.9	1.9	3.7	-0.8	1.9	1.7	-1.4	1.6	0.4	-1.2	-1.6	1.5	1.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.1	1.9	-1.1	-1.5	1.5	-1.1	1.5	2.0	1.5	0.1	1.1	1.8
Medication: Cholesterol lowering	0.2	0.4	1.8	0.3	0.0	-0.1	0.3	-0.3	1.3	0.1	-0.2	0.6	1.0	0.7
Depression (self-reported)	1.3	1.5	3.6	-1.4	0.6	1.9	-1.9	1.1	-0.7	-1.4	-0.7	-0.7	-0.5	-1.6
Medication: Lansoprazole	0.7	0.8	1.5	0.6	-1.0	-1.2	0.9	-1.2	-0.5	0.8	1.2	-0.5	-1.0	0.6
Prospective memory result	0.7	0.9	4.8	0.5	-1.0	1.0	-0.2	0.0	2.2	-0.3	0.9	0.7	0.8	0.6
Lung cancer (father)	0.7	0.8	2.0	-0.3	0.8	1.1	-1.4	1.4	0.4	-0.8	-0.8	0.7	0.7	-0.5
Illnesses of mother	0.9	1.1	3.6	-0.4	0.3	1.0	-0.8	1.2	1.9	-0.6	-0.2	1.4	1.6	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	10.5	-2.2	3.2	2.6	-2.8	1.3	-1.1	-1.6	-3.1	1.1	0.6	-2.4
Pulse wave Arterial Stiffness index	2.3	2.7	5.1	1.7	-1.5	-2.3	1.4	-1.7	-1.0	1.8	1.6	-2.0	-1.6	0.8
Impedance of arm (left)	0.7	3.4	6.5	-2.3	2.2	2.1	-2.1	2.2	-0.0	-2.1	-2.5	0.0	0.1	-1.8
Arm fat mass (right)	0.6	2.3	7.9	-0.8	-0.0	-0.9	0.7	-1.4	-2.5	-0.0	-0.2	-2.8	-2.4	-1.0
Trunk predicted mass	0.8	4.8	9.6	-2.4	2.9	1.1	-1.8	0.9	-2.7	-2.3	-2.4	-1.4	-1.9	-3.1
Standing height	1.9	18.4	37.0	-4.9	6.1	3.8	-4.6	3.5	-2.6	-4.7	-5.8	-0.3	-1.3	-5.4
Length of working week for main job	0.3	0.3	1.1	-0.2	1.1	-0.1	-0.5	0.3	-0.9	-0.4	-0.7	0.1	0.1	-0.4
Exposure to tobacco smoke at home	1.7	1.9	7.6	0.8	0.9	1.1	-0.8	1.3	1.8	0.5	-0.2	2.1	2.8	0.5
Breastfed as a baby	0.1	0.1	0.9	-0.0	0.2	0.2	-0.0	0.3	0.9	-0.2	-0.3	0.3	0.4	0.0
Tense / ‘highly strung’	0.7	1.2	2.8	-1.3	0.7	1.3	-1.3	1.7	-0.8	-0.8	-1.1	-0.4	-0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.7	-0.6	1.7	1.7	-1.9	1.6	-0.4	-1.1	-1.0	1.5	1.3	-1.0
Hair/balding pattern: Pattern 4	0.7	1.8	7.8	-0.5	2.5	1.2	-0.9	0.4	-0.9	-0.0	-2.8	0.8	1.0	-0.8
Birth weight of first child	0.3	0.6	2.7	0.4	-1.6	-0.4	0.2	0.4	-0.2	-0.4	1.5	-0.3	-1.0	0.2
Peak expiratory flow (PEF)	0.2	0.6	2.7	0.7	0.1	-0.8	0.3	-1.6	-0.4	1.3	0.1	0.1	0.1	0.4
Pulse wave reflection index	2.7	3.4	7.7	1.8	-2.7	-2.0	1.3	-1.4	-0.3	2.2	2.8	-1.7	-1.5	1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	5.6	0.6	-2.4	-1.4	1.6	-0.9	0.0	0.8	1.8	-1.6	-1.5	0.6
Loud music exposure frequency	2.3	2.5	5.9	2.0	0.4	-1.5	1.7	-2.0	1.2	2.4	0.3	1.0	1.8	1.7
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	8.6	1.5	-1.0	-0.7	1.1	0.2	2.9	0.4	1.3	1.4	2.1	1.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.0	0.1	-0.5	-0.1	0.5	-0.1	-0.6	0.1	0.2	-1.3	-1.4	-0.2
Blood clot in the leg (DVT)	0.5	0.7	1.7	-0.6	1.3	0.5	0.2	0.9	1.2	0.6	-1.3	-0.2	0.9	-0.2
Medication: Paracetamol	1.0	1.6	2.6	1.6	-1.0	-1.5	1.6	-1.2	1.2	1.3	1.4	-1.1	-0.4	1.3
Headache pain in last month	0.3	0.5	1.6	1.0	-0.0	-0.4	0.1	-1.3	-0.8	0.8	0.6	0.5	0.5	0.4
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.3	-0.4	-0.2	0.1	-0.2	0.5	-0.2	-0.5	0.1	0.1	-0.1	-0.2
Glaucoma (self-reported)	0.8	1.0	1.7	1.2	-1.2	-0.7	0.6	-1.0	1.2	0.9	1.2	0.2	0.7	1.3
Gout (self-reported)	1.4	1.9	5.8	1.3	-0.9	-1.4	1.4	-2.4	-0.7	2.0	1.1	-1.4	-0.7	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.6	0.8	-0.1	-0.7	0.7	-0.1	1.6	0.5	0.3	0.5	0.8	0.9
Medication: Amlodipine	0.3	0.5	1.4	-0.2	1.1	-0.2	0.6	-1.0	-0.1	-0.5	-1.2	0.7	0.7	-0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	-0.6	0.3	0.3	-0.1	0.7	0.7	-0.9	-0.4	0.4	0.3	-0.0
Birth weight	0.2	0.3	2.0	0.2	0.5	-0.3	-0.4	-0.5	-1.4	-0.4	0.1	-0.1	-0.8	-0.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.4	1.5	-1.5	-0.6	0.6	-0.0	1.3	0.7	1.2	1.5	1.1	1.5
High blood pressure (siblings)	0.2	0.3	1.2	-0.3	-0.5	1.0	-1.1	0.1	-0.4	-0.3	0.3	1.0	0.2	-0.1
Forced vital capacity (FVC), Best measure	2.1	7.6	16.1	-2.7	4.0	3.1	-3.4	2.1	-1.4	-2.3	-4.0	1.5	0.6	-3.0
Body fat percentage	0.3	1.0	4.1	-0.9	0.6	-0.3	0.4	-0.5	-1.6	-0.2	-0.8	-2.0	-1.2	-0.8
Leg fat percentage (right)	0.2	0.6	3.3	-0.3	0.2	-0.6	0.7	-0.6	-0.9	0.5	-0.2	-1.8	-1.0	-0.3
Arm fat-free mass (right)	0.5	2.4	6.2	-1.5	2.1	0.2	-0.8	-0.1	-2.5	-1.6	-1.5	-1.4	-1.6	-2.1
Exposure to tobacco smoke outside home	1.7	2.3	3.7	-1.9	1.3	1.4	-1.3	1.1	-1.3	-1.6	-1.7	-1.4	-1.6	-1.8
Comparative body size at age 10	0.3	0.8	1.7	0.6	-0.3	-1.0	1.1	-1.3	-0.8	1.3	0.0	-1.1	-0.7	0.3
Number of full brothers	1.0	1.3	4.3	1.4	-0.7	-1.1	1.3	-1.3	0.7	2.1	0.5	-0.2	0.7	1.4
Worry too long after embarrassment	0.3	0.5	1.8	-0.2	-1.0	0.7	-0.1	1.3	1.4	-0.1	0.4	-0.2	-0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	6.9	-1.2	1.8	2.2	-2.0	2.6	1.0	-1.8	-1.9	1.9	1.6	-1.0
Wheeze or whistling in the chest in last year	1.0	1.8	5.7	-1.1	2.1	1.8	-0.8	0.7	1.0	-0.3	-2.4	1.0	1.3	-0.8
Number of children fathered	0.7	0.8	1.9	-0.1	-1.3	-0.7	0.8	-0.6	0.7	-0.8	1.4	-1.0	-1.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.1	1.7	-0.9	-1.5	2.0	-0.8	0.1	1.4	1.2	0.4	0.3	1.5
Age at first live birth	0.2	0.3	1.1	-0.3	0.1	0.7	-0.3	-0.3	1.0	-0.7	-0.5	0.5	0.6	0.1
Pulse wave peak to peak time	2.7	3.1	5.7	-2.0	1.9	2.4	-1.7	1.8	0.7	-2.1	-2.0	1.7	1.4	-1.2
Health satisfaction	0.6	0.7	2.0	-0.7	0.8	0.2	-0.5	0.6	-1.2	-0.1	-0.6	-1.4	-1.2	-1.1
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.6	-0.2	0.2	0.2	0.1	0.4	-0.5	-0.2	-0.3	-0.4	-0.2
Qualifications: College or University degree	0.2	0.5	1.6	-0.6	-0.5	-0.2	-0.0	0.5	-1.2	-1.2	0.4	-0.8	-1.0	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.3	0.3	0.1	-0.1	0.1	-0.2	-0.2	-0.5	0.6	0.4	-0.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.7	-1.1	1.3	1.5	-1.3	1.6	-0.6	-0.7	-1.6	0.6	0.3	-1.1
Emphysema/chronic bronchitis	1.5	1.7	4.9	0.6	2.0	0.4	0.0	0.6	0.9	0.7	-1.6	2.1	2.2	0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	-1.1	0.2	1.6	-1.1	0.9	-0.0	-1.0	-0.9	1.0	0.2	-0.8
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.3	0.2	0.1	0.2	0.8	0.8	-0.2	-0.2	-0.6	0.0	-0.0
Medication: Blood pressure	0.1	0.2	0.9	-0.1	1.0	0.4	-0.4	0.2	-0.2	0.1	-0.6	-0.3	-0.0	-0.6
Angina (self-reported)	0.5	0.7	2.4	1.0	0.8	-0.3	0.4	0.1	1.1	0.2	-0.3	1.3	1.5	0.7
Migraine (self-reported)	0.5	0.7	3.0	-0.0	0.7	0.6	-0.6	0.0	0.7	-0.4	0.1	1.7	1.5	-0.0
Medication: Ibuprofen	0.8	0.9	2.5	1.2	-0.8	-1.0	0.8	-0.4	0.9	1.6	0.9	-0.1	0.5	1.3
Medication: Allopurinol	0.4	0.6	2.4	-0.1	-0.4	-0.3	0.4	-1.6	-1.1	0.6	-0.0	-1.1	-1.0	-0.2
Medication: Omeprazole	2.5	3.0	7.5	-1.7	2.7	1.0	-1.2	1.6	-2.5	-1.1	-2.2	-0.7	-0.5	-2.1
Medication: Seretide 50 evohaler	1.6	1.9	4.9	-1.1	1.9	1.8	-1.3	1.4	-0.1	-1.1	-2.2	1.0	0.8	-1.1
Mean time to correctly identify matches	0.1	0.2	0.6	0.4	0.3	0.1	-0.2	0.5	-0.3	0.5	-0.3	0.8	0.6	0.3
Heart disease (mother)	3.2	3.9	8.1	-2.0	2.9	2.4	-2.3	1.6	-0.7	-2.0	-2.8	0.5	0.7	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.3	0.4	-0.1	-0.6	0.4	-0.7	-0.2	-0.3	-0.5	-0.5	-0.7
Whole body fat mass	0.4	1.8	5.1	-1.2	1.0	-0.4	0.3	-0.7	-2.2	-0.6	-1.1	-2.3	-1.7	-1.2
Leg fat mass (right)	0.4	1.4	5.0	-0.9	0.7	-0.6	0.4	-0.6	-1.9	-0.2	-0.7	-2.2	-1.7	-1.0
Arm predicted mass (right)	0.5	2.4	6.0	-1.4	2.1	0.2	-0.7	-0.0	-2.4	-1.6	-1.5	-1.3	-1.5	-2.0
Pulse rate, automated reading	0.5	1.5	3.3	1.4	-1.8	-1.4	1.4	-1.2	0.1	1.1	1.4	0.1	-0.7	1.2
Alcohol intake frequency.	0.3	0.7	1.8	-1.0	1.3	0.9	-0.9	0.3	-0.6	-1.1	-1.0	0.1	0.1	-1.0
Comparative height size at age 10	1.2	6.4	14.3	-3.1	3.8	2.3	-2.3	1.6	-1.9	-2.4	-3.7	0.3	-0.6	-3.2
Number of full sisters	1.4	1.8	5.7	-1.4	-0.4	-0.3	-0.3	0.5	-2.0	-1.4	0.2	-1.9	-2.4	-1.2
Suffer from ‘nerves’	0.7	1.1	2.5	-0.8	0.2	0.9	-1.3	1.6	-1.0	-1.0	0.0	-1.2	-1.1	-1.2
Overall health rating	0.7	1.4	4.5	-0.7	1.9	0.3	-0.8	-0.4	-2.1	-0.0	-1.4	-1.2	-0.8	-1.4
Chest pain or discomfort	0.6	0.9	3.3	-0.8	1.8	0.5	-0.2	1.3	-0.0	-0.4	-1.8	-0.1	0.4	-0.4
Had major operations	0.4	0.5	2.5	-0.4	-0.7	0.0	0.3	0.6	-0.5	-0.5	0.3	-1.1	-1.6	-0.6
Age at last live birth	0.1	0.1	0.6	-0.2	-0.6	-0.4	0.2	-0.8	0.4	-0.1	0.2	0.1	-0.1	0.3
Family relationship satisfaction	0.3	0.4	1.2	-0.5	0.3	1.0	-1.1	0.3	-0.8	-0.3	-0.1	-0.4	-0.5	-0.8
Leg pain on walking	0.6	0.8	2.1	0.6	-1.4	-0.6	0.7	-0.7	0.9	0.5	1.3	-0.8	-0.7	0.7
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	7.9	2.3	-1.1	-1.3	1.8	-1.7	2.8	2.2	1.1	1.9	1.9	2.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.4	0.9	0.4	-0.4	0.2	-0.0	-0.1	-0.9	-0.4	-0.1	-0.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.0	1.3	-2.0	-1.6	1.2	-1.3	-0.0	0.7	2.0	0.3	-0.2	1.4
Medication: Aspirin	0.5	0.7	1.8	1.0	0.4	-1.4	1.0	-1.3	0.3	0.5	0.1	0.4	0.8	1.0
Supplements: Vitamin C	0.3	0.4	1.9	0.5	0.6	0.1	-0.0	-0.4	-0.2	-0.1	-0.3	1.4	1.1	0.2
Knee pain experienced in last month	0.3	0.5	1.7	0.3	-1.3	-0.6	0.6	0.6	-0.0	0.3	1.0	-0.8	-0.9	0.4
Hypertension (Self-reported)	0.4	1.1	2.2	-1.1	1.5	1.1	-0.7	0.9	-0.8	-0.9	-1.4	-1.0	-0.7	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	8.0	-1.7	0.2	0.1	-0.5	0.3	-2.6	-1.0	-0.1	-2.7	-2.8	-2.1
Illnesses of father: Heart disease	0.8	1.0	3.8	0.6	-0.3	-1.2	0.7	-1.3	-2.0	0.9	0.4	-1.0	-1.3	-0.0
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.7	0.7	0.5	-0.3	0.3	-0.1	-0.5	-0.5	-0.7	0.2	-0.7
Smoking status: Previous	0.8	1.2	4.6	0.9	-0.0	-2.1	1.8	-0.8	-0.5	1.1	0.5	-1.0	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.8	-2.2	2.1	2.0	-2.4	1.2	-0.9	-2.0	-2.4	0.0	-0.7	-2.4
Whole body fat-free mass	0.7	4.1	9.0	-2.2	2.2	0.6	-1.2	0.4	-3.0	-2.1	-1.8	-2.0	-2.3	-2.8
Leg fat-free mass (right)	0.8	4.3	12.1	-2.1	1.5	0.2	-0.9	0.0	-3.5	-2.0	-1.2	-2.6	-2.9	-2.6
Arm fat percentage (left)	0.6	2.3	7.8	-0.7	-0.2	-1.1	0.9	-1.5	-2.6	0.0	-0.1	-2.8	-2.2	-0.6
Average weekly red wine intake	1.7	2.5	4.5	2.1	-1.3	-1.5	1.8	-0.1	2.0	1.7	1.9	0.5	0.9	2.1
Handedness (chirality/laterality): Left-handed	3.8	4.6	10.9	-2.8	2.5	1.7	-2.0	0.9	-2.4	-1.6	-3.3	-1.1	-1.0	-2.6
Mood swings	0.2	0.4	1.7	-0.7	0.4	1.0	-0.3	1.3	0.4	-0.0	-0.2	-0.7	0.2	-0.6
Loneliness, isolation	0.2	0.3	1.0	0.0	1.0	-0.1	-0.2	0.9	-0.5	0.5	-0.6	0.0	-0.1	-0.5
Long-standing illness, disability or infirmity	1.1	1.7	4.9	-0.8	2.2	1.8	-1.1	1.1	0.6	-0.7	-1.8	1.0	1.1	-0.9
Ever had bowel cancer screening	0.5	0.6	2.8	0.4	-1.7	-0.3	0.6	0.2	0.6	0.1	1.3	-0.3	-0.3	0.6
Diabetes diagnosed by doctor	0.7	1.1	3.4	-0.0	1.5	1.2	-0.7	0.2	1.3	-0.1	-1.1	1.4	1.9	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	-0.6	0.2	0.3	-0.4	0.5	-0.9	-0.4	-0.3	-0.8	-1.4	-0.8
Friendships satisfaction	1.6	2.0	4.3	-1.3	1.3	0.7	-1.5	0.9	-2.1	-1.2	-0.9	-1.5	-1.5	-1.9
Qualifications: nursing, teaching	1.7	2.6	6.7	1.3	-1.8	-2.6	2.2	-2.0	0.4	0.5	2.0	-0.1	-0.1	1.9
Commuting to job workplace: Walk	2.4	2.6	5.3	-2.1	1.2	1.8	-1.8	2.0	-0.8	-2.3	-1.5	0.1	-0.2	-1.8
Eye problems/disorders: Cataract	0.3	0.4	0.7	0.2	-0.8	-0.8	0.7	0.1	-0.6	-0.5	0.9	-0.6	-0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	0.1	-0.5	-0.5	0.3	-0.6	-1.0	0.4	0.3	-1.2	-1.2	-0.2
Medication for cholesterol	0.4	0.6	1.4	0.5	-1.1	-1.2	0.7	-1.1	0.5	0.1	1.2	-0.1	-0.2	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.5	-0.4	1.2	0.1	-0.1	-0.1	-0.7	0.0	-0.9	-0.2	0.3	-0.5
Back pain experienced in last month	0.9	1.3	3.5	1.6	-0.5	-0.8	0.9	-0.4	1.4	1.9	1.1	0.3	1.1	1.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.3	0.1	0.4	0.2	0.4	0.4	0.4	-0.4	-0.3	0.2	-0.0
Breast cancer (self-reported)	0.3	0.4	1.1	0.4	-1.1	-0.4	0.7	-0.7	0.5	0.5	0.7	-0.2	-0.4	0.6
Asthma (self-reported)	0.9	1.7	4.3	-0.8	2.1	1.5	-1.4	1.4	0.1	-1.1	-1.6	1.3	1.3	-0.9
Osteoporosis (self-reported)	1.3	1.7	4.7	-0.1	1.0	1.6	-1.4	1.6	1.3	0.2	-0.9	2.2	1.7	-0.3
Osteoarthritis (self-reported)	0.4	0.5	1.6	-0.1	-0.8	-0.4	0.2	-1.3	-0.5	-0.1	0.7	-0.9	-1.2	-0.1
Medication: Aspirin	0.4	0.5	1.5	0.8	0.6	-1.2	0.9	-1.2	0.0	0.3	-0.1	0.3	0.6	0.8
Medication: Gliclazide	0.4	0.4	0.8	-0.7	0.7	0.8	-0.9	0.9	0.2	-0.5	-0.1	-0.2	0.3	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	2.4	0.1	-0.1	0.4	-0.6	0.5	1.5	-0.3	0.3	1.2	1.1	0.4
Smoking status: Current	0.4	0.6	1.4	-0.8	1.0	0.5	-0.8	0.1	-0.6	0.1	-1.2	-1.0	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	4.0	-1.9	1.9	1.6	-1.9	1.4	-1.7	-1.3	-2.0	0.3	-0.3	-2.0
Whole body water mass	0.7	4.1	9.6	-2.1	2.2	0.5	-1.2	0.2	-3.1	-2.1	-1.7	-1.9	-2.3	-2.8
Leg predicted mass (right)	0.8	4.2	11.7	-2.1	1.4	0.2	-0.9	-0.0	-3.4	-2.0	-1.2	-2.6	-2.8	-2.6
Arm fat mass (left)	0.6	2.5	8.2	-1.0	0.3	-0.9	0.6	-1.5	-2.9	-0.3	-0.5	-2.8	-2.4	-1.1
Number of self-reported non-cancer illnesses	1.8	3.2	9.5	-1.4	3.1	1.8	-2.3	1.3	-0.6	-2.0	-2.1	0.3	0.4	-2.0
Average weekly champagne plus white wine intake	0.4	0.6	1.5	0.6	-1.2	-1.0	0.9	-0.4	-0.1	0.4	1.2	-0.3	-0.5	0.9
Miserableness	0.3	0.6	1.1	-1.0	0.7	1.0	-0.6	1.0	0.0	0.1	-0.8	-1.0	-0.1	-1.0
Guilty feelings	1.0	1.5	3.6	-1.6	1.2	1.4	-1.0	1.9	-0.4	-1.2	-1.6	-0.0	-0.1	-1.4
Wears glasses or contact lenses	1.4	1.6	3.3	1.4	-1.2	-1.2	1.8	-0.8	1.5	1.2	1.4	0.3	0.8	1.6
Ever taken oral contraceptive pill	0.8	0.9	2.4	0.9	-0.8	-0.3	0.1	-0.8	1.0	0.6	1.0	1.6	1.3	0.9
Hearing aid user	0.6	0.7	1.7	1.1	-0.7	-0.0	-0.2	-0.1	0.9	0.8	1.1	1.3	0.9	0.6
Mother’s age at death	0.4	0.6	1.7	-0.8	0.8	0.2	-0.2	1.3	-0.5	-1.1	-0.9	0.9	0.4	-0.3
Financial situation satisfaction	1.2	1.4	3.3	1.7	-0.2	-1.8	1.6	-1.3	0.5	1.4	0.9	-0.1	0.5	1.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	0.1	-0.5	0.3	-0.4	0.6	0.1	-0.3	0.8	-0.0	-0.5	-0.2
Commuting to job workplace: Public transport	0.5	0.5	1.5	-0.8	0.5	0.6	-0.5	1.2	-1.1	-1.0	-0.3	-0.2	-0.3	-0.8
Eye problems/disorders: Glaucoma	1.1	1.3	2.9	1.3	-0.9	-0.5	0.5	-1.1	1.7	1.4	1.1	0.6	1.2	1.5
Medication: Blood pressure	1.0	1.9	5.9	-1.2	1.1	0.5	-0.2	0.4	-2.4	-0.3	-1.3	-2.0	-2.0	-1.6
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.5	2.0	-0.9	-1.9	2.1	-1.6	0.6	1.7	1.4	-0.5	0.3	1.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.6	0.3	-0.9	-0.2	0.1	-0.5	0.9	-0.4	1.3	-0.0	-0.1	0.4
High cholesterol (Self-reported)	0.3	0.5	1.6	1.0	-0.2	-0.6	0.7	-1.3	0.1	0.9	0.2	0.7	0.6	1.0
Medication: Bendroflumethiazide	0.8	1.2	2.9	-1.1	1.7	0.7	-0.7	0.1	-1.2	-0.6	-1.6	-0.7	-1.0	-1.5
Medication: Paracetamol	0.8	1.2	3.1	1.1	-0.6	-1.2	1.2	-1.3	0.6	1.1	1.1	-1.8	-1.0	0.7
Medication: Lisinopril	0.2	0.3	1.2	0.2	0.1	0.4	-0.1	-0.3	1.1	-0.6	0.1	0.5	1.0	0.2
Medication: Atorvastatin	0.4	0.4	1.3	0.3	-1.2	-0.8	0.1	-0.6	-0.1	-0.3	1.0	-0.5	-1.0	0.3
Illnesses of father: High blood pressure	0.2	0.3	0.9	-0.0	-0.2	0.0	0.1	-0.9	-0.9	0.1	0.3	-0.5	-0.9	-0.5
Alcohol drinker status: Never	0.2	0.2	0.6	0.4	-0.6	-0.5	0.6	-0.0	0.0	-0.0	0.8	0.4	0.4	0.5
Ever smoked	0.6	1.1	3.7	-0.8	0.7	-0.8	0.5	0.4	-1.1	-0.1	-0.9	-1.9	-1.7	-0.8
Basal metabolic rate	0.8	4.4	10.8	-2.2	2.2	0.4	-1.1	0.1	-3.3	-2.0	-1.8	-2.3	-2.5	-2.8
Leg fat percentage (left)	0.2	0.5	3.0	-0.4	0.4	-0.3	0.6	-0.4	-0.9	0.4	-0.5	-1.7	-0.8	-0.4
Arm fat-free mass (left)	0.4	2.1	5.1	-1.5	1.9	0.3	-0.8	-0.0	-2.2	-1.3	-1.5	-1.2	-1.5	-2.0
Number of operations (self-reported)	1.1	1.6	6.4	0.4	-1.0	-1.4	1.1	-0.3	-1.3	0.4	1.2	-2.5	-2.0	-0.1
Average weekly beer plus cider intake	2.2	3.2	8.5	2.0	-2.9	-1.7	1.7	-1.4	1.2	1.3	2.5	1.0	0.0	2.3
Irritability	0.3	0.5	2.5	-0.6	-0.2	-0.2	0.5	1.2	-0.0	0.2	0.1	-1.6	-0.6	-0.5
Risk taking	0.1	0.2	0.7	0.3	0.7	-0.8	0.5	-0.3	-0.1	0.6	-0.2	0.0	0.1	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	-0.1	-0.2	-0.5	1.0	0.1	-0.1	-0.3	0.2	-1.0	-1.0	-0.1
Fractured/broken bones in last 5 years	1.1	1.5	4.7	1.4	-0.9	-0.2	0.2	-0.8	2.2	0.7	1.5	1.3	1.4	1.3
Age started oral contraceptive pill	0.3	0.4	1.1	0.3	-0.5	-0.0	0.6	0.7	1.1	0.1	0.2	0.7	1.0	0.9
Diastolic blood pressure, automated reading	0.8	2.6	8.5	-1.8	0.2	1.0	-1.1	0.9	-2.1	-1.2	-1.0	-1.9	-2.9	-1.9
Ever depressed for a whole week	0.9	1.1	4.6	-0.8	1.2	0.1	-0.7	0.5	-2.1	-0.3	-1.1	-0.8	-1.0	-1.1
Unable to work because of sickness or disability	1.7	2.2	4.1	-1.7	0.9	1.4	-1.8	1.1	-1.7	-1.8	-0.6	-1.1	-1.4	-2.0
Commuting to job workplace: Cycle	2.3	2.8	5.9	1.8	-1.9	-0.8	0.9	-0.9	2.4	0.5	2.2	2.0	1.7	2.1
Myopia	0.2	0.3	0.8	-0.3	-0.9	0.2	-0.3	-0.5	0.3	-0.6	0.5	-0.6	-0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.6	1.1	-1.6	-1.0	0.8	-0.7	1.0	1.0	1.5	0.8	0.8	1.4
Cholesterol lowering medication	0.3	0.4	1.0	0.8	0.7	-0.2	0.2	-0.2	0.4	0.7	-0.3	0.9	1.0	0.7
Medication: Omeprazole (e.g. Zanprol)	3.8	4.6	12.2	-2.3	2.3	1.5	-1.9	1.9	-3.5	-1.3	-2.0	-1.5	-1.8	-2.8
Pain experienced in last month	0.7	1.2	3.2	-1.4	0.2	0.1	-0.4	0.5	-1.6	-1.0	-0.7	-1.2	-1.8	-1.3
Supplements: Calcium	2.9	3.2	6.4	-2.0	2.0	1.4	-1.8	1.6	-1.6	-2.5	-2.4	0.6	-0.4	-2.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	-0.1	-0.5	-0.5	-0.1	-0.7	-0.5	0.6	0.1	-0.8	-0.8	-0.0
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.3	-1.2	0.3	0.4	-0.9	0.9	-1.0	-0.6	-0.6	-1.8	-1.5	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.7	-0.7	1.2	0.7	0.1	1.0	1.2	0.4	-1.3	0.1	1.0	-0.3
Heart disease (siblings)	0.5	0.6	1.3	0.2	1.1	0.8	-0.9	1.0	-0.1	-0.3	-0.9	0.5	1.0	-0.4
Alcohol drinker status: Previous	1.4	1.6	3.9	0.6	-1.3	-1.5	1.6	-1.2	-1.2	1.2	0.8	-1.4	-2.0	0.5
Pack years of smoking	0.2	0.3	1.3	-0.3	-0.2	0.2	0.0	-0.2	-0.0	0.6	-0.2	-1.1	-1.1	-0.3
Impedance of whole body	0.8	4.2	7.4	-1.4	2.5	2.6	-2.2	2.5	1.9	-1.2	-2.7	1.8	2.0	-0.9
Leg fat mass (left)	0.4	1.5	4.8	-1.0	0.8	-0.4	0.2	-0.5	-2.0	-0.4	-0.9	-2.2	-1.7	-1.2
Arm predicted mass (left)	0.4	1.8	5.3	-1.1	1.9	0.1	-0.6	-0.3	-2.3	-1.1	-1.3	-1.2	-1.4	-1.8