Hub : Genes

C7orf46

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0168	0.0096	8.9e-03	0.015	0.012	0.000	NA	0.005	7.2e-03	1.5e-02	2.8e-01	NA	8.1e-02
2	TCGA	Brain Lower Grade Glioma	0.0758	0.0306	1.9e-09	0.094	0.045	0.069	NA	0.017	7.4e-11	6.4e-06	2.9e-08	NA	4.4e-03
3	TCGA	Pheochromocytoma and Paraganglioma	0.2730	0.0820	1.8e-10	0.215	0.211	0.206	NA	0.232	5.3e-09	7.7e-09	1.2e-08	NA	1.2e-09
4	TCGA	Prostate Adenocarcinoma	0.1052	0.0359	6.7e-15	0.176	0.157	0.165	NA	0.176	4.8e-18	3.5e-16	6.0e-17	NA	5.1e-18
5	TCGA	Stomach Adenocarcinoma	0.0500	0.0280	3.2e-03	0.007	0.009	0.012	NA	0.017	9.1e-02	6.4e-02	4.0e-02	NA	2.1e-02
6	TCGA	Testicular Germ Cell Tumors	0.1940	0.1050	5.4e-03	0.076	0.094	0.085	NA	0.079	1.2e-03	3.4e-04	6.2e-04	NA	9.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.1	1.8	2.9	1.5	-1.4	-1.7	-1.7	-0.7	-0.5
Bipolar Disorder or Schizophrenia	3.4	8.2	11.1	3.3	-3.0	-3.2	-3.0	-2.1	-2.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.3	0.5	-0.8	-0.6	-0.4	-1.4	-1.5
Depression (Nagel 2018)	0.9	1.3	2.1	-1.4	1.1	1.3	1.4	0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.7	1.5	-1.2	-1.4	-1.5	-1.6	0.9
Neuroticism (Nagel 2018)	0.4	0.9	1.8	0.8	-1.0	-1.1	-1.0	-1.3	-0.4
Schizophrenia (2018)	3.4	7.0	9.3	3.0	-2.7	-2.8	-2.5	-2.2	-2.6
Schizophrenia vs Biploar Disorder	4.0	5.3	7.1	2.2	-2.5	-2.4	-2.3	-2.7	-1.5
Worry (Nagel 2018)	0.2	0.4	0.7	0.6	-0.7	-0.7	-0.7	-0.8	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.8	0.3	0.2	-0.1	0.1	-0.6	1.4
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.3	0.6	0.6	-0.0	-0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-0.4	0.4	0.5	0.7	-0.9	1.3
Crohns Disease (2017)	0.3	0.6	1.2	1.1	-0.2	-0.6	-0.6	-0.7	-1.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	0.4	0.1	-0.3	-0.3	-0.4	-0.4
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.2	0.0	-0.4	-0.5	-0.2	-0.0
Major Depression (MDD)	0.6	0.7	2.6	-0.4	0.7	0.4	0.5	-0.9	1.6
Reaction Time	5.5	10.4	14.7	3.4	-3.8	-3.5	-3.7	-2.3	-2.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	0.6	-0.8	-0.9	-0.9	-0.7	0.2
Breast Cancer	0.3	0.6	1.1	-0.6	1.1	1.0	0.8	0.7	-0.3
Ovarian Cancer	0.4	0.6	1.0	-0.6	1.0	0.9	0.9	-0.1	-0.7
Prostate Cancer	0.2	0.3	1.3	0.4	0.2	-0.2	-0.4	0.2	1.1
Age at First Birth	0.1	0.1	0.4	-0.2	-0.0	-0.2	-0.2	-0.6	0.2
Bipolar Disorder (2011)	0.6	0.6	1.4	1.2	-0.4	-0.9	-1.0	0.5	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.4	-0.2	-0.2	-0.3	-0.5	-0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.3	0.5	0.3	0.3	-0.0	-0.1
Crohns Disease (2012)	0.1	0.1	0.4	0.3	-0.0	-0.3	-0.1	-0.6	-0.0
Mean Putamen Volume	0.1	0.1	0.2	-0.0	0.3	0.3	0.2	0.4	0.3
Fasting Glucose	1.0	1.2	2.0	-1.1	1.4	1.3	1.2	0.5	0.9
HbA1C	0.4	0.5	0.9	0.7	-0.7	-0.6	-0.7	0.2	-1.0
HDL Cholesterol	0.5	0.8	1.3	1.1	-0.8	-1.0	-1.0	-0.8	-0.4
LDL Cholesterol	0.3	0.4	0.7	0.8	-0.7	-0.7	-0.8	-0.3	0.4
Lupus	0.5	0.8	3.5	-0.4	0.9	0.4	0.4	1.9	0.2
Neuroticism (2016)	1.2	1.8	2.6	1.5	-1.4	-1.6	-1.6	-1.0	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.5	0.3	-0.2	-0.2	-0.2	-0.7	0.2
Rheumatoid Arthritis	0.0	0.1	0.2	-0.3	0.1	-0.1	0.0	0.5	0.2
Schizophrenia (2014)	4.2	9.3	11.8	3.4	-3.1	-3.3	-3.0	-2.7	-2.9
Triglycerides	0.5	0.9	1.3	-0.9	1.1	1.1	1.1	0.2	0.8
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.1	-1.4	1.3	1.0	1.1	1.4	0.4
Ulcerative Colitis	0.1	0.1	0.3	-0.3	0.4	0.2	0.1	0.5	0.5
Blood Eosinophil Count	0.2	1.5	1.8	-1.4	1.1	1.3	1.4	-1.3	0.8
Blood Platelet Count	0.2	1.9	3.3	-1.2	1.8	1.5	1.4	0.8	1.3
Blood Red Count	0.0	0.2	0.5	-0.3	0.0	0.2	0.4	0.3	-0.7
Blood White Count	0.6	4.6	6.8	-2.6	2.1	2.4	2.5	-0.4	2.1
Heel T-Score	1.3	10.6	15.8	-3.7	3.5	3.7	4.0	2.3	1.7
BMI	0.0	0.2	0.8	0.4	-0.3	0.1	0.0	-0.9	-0.4
Height	1.8	35.3	46.8	6.4	-6.0	-6.6	-6.7	0.6	-6.8
Waist Hip Ratio (WHR)	0.4	1.6	2.7	-1.6	1.1	1.2	1.2	0.9	1.4
Systolic Blood Pressure	0.1	0.4	1.1	-0.6	0.3	0.3	0.6	1.0	-0.9
Smoking Status	0.1	0.2	0.5	0.4	-0.5	-0.3	-0.4	-0.3	-0.7
Allergy or Eczema	0.2	0.4	1.0	1.0	-0.4	-0.5	-0.7	-0.1	0.8
Cardiovascular Disease	0.3	0.9	3.1	0.5	-1.0	-0.7	-0.5	-0.4	-1.8
Hypothyroidism (self reported)	0.2	0.5	1.0	0.2	-1.0	-0.8	-0.7	0.1	-1.0
Respiratory disease	0.3	0.6	1.6	1.2	-0.4	-0.4	-0.6	-1.3	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	-0.0	0.0	-0.0	0.0	-0.9	0.1
Lung FEV1/FVC ratio	0.3	1.5	2.2	-1.5	1.0	1.3	1.2	1.5	0.2
Lung FVC	0.3	1.3	3.5	1.3	0.2	-0.5	-1.0	1.9	1.1
Neuroticism	0.3	0.7	2.3	0.5	-0.7	-0.6	-0.4	-1.5	-0.7
Chronotype (morning person)	0.7	1.5	2.9	-0.9	1.3	1.4	1.3	-0.0	1.7
Hair Pigment	0.0	0.1	0.3	0.1	-0.3	-0.1	-0.0	-0.5	-0.5
Tanning	0.3	4.3	5.2	-1.7	2.2	2.1	1.8	2.2	2.3
Hand grip strength (left)	0.3	0.7	3.0	-0.7	0.5	0.4	0.3	1.7	0.3
Number of treatments/medications taken	1.5	2.6	5.6	1.6	-1.6	-1.4	-1.2	-2.4	-1.3
Average weekly spirits intake	0.2	0.3	0.8	0.1	-0.4	-0.1	-0.1	-0.9	-0.7
Sensitivity / hurt feelings	0.4	0.7	1.1	0.9	-0.8	-1.0	-1.0	-0.8	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.4	0.3	0.3	0.4	0.2	-0.5
Hearing difficulty/problems: Yes	0.7	1.1	2.7	1.1	-1.0	-1.0	-0.9	-1.6	-0.2
Relative age of first facial hair	0.1	0.3	0.5	-0.4	0.6	0.6	0.5	0.7	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	0.8	-1.0	-0.8	-0.7	-0.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	0.6	-0.5	-0.1	-0.3	-0.1	-1.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.1	-1.0	0.5	0.9	1.1	0.1	-0.4
Systolic blood pressure, automated reading	0.6	1.6	3.8	-0.9	1.4	1.1	1.2	2.0	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.7	0.1	-0.1	0.2	0.3	-0.1	-1.3
Angina	1.6	2.1	3.4	1.9	-1.3	-1.4	-1.6	-1.8	0.2
Medication for hormone replacement therapy	1.8	2.1	3.1	1.3	-1.8	-1.5	-1.3	-0.9	-1.7
Vitamin and mineral supplements	0.9	1.3	3.9	-1.2	0.7	0.8	0.9	2.0	0.5
Supplements: Zinc	0.1	0.2	0.7	0.2	-0.1	-0.0	-0.1	-0.3	-0.9
Medication: Co-codamol	0.9	1.1	1.9	-1.1	1.1	1.4	1.3	0.0	0.8
Medication: Metformin	0.4	0.6	0.9	0.8	-0.8	-0.6	-0.6	-1.0	-0.8
Diabetes (father)	0.3	0.4	0.8	-0.5	0.4	0.7	0.8	-0.9	-0.1
Diabetes (mother)	0.1	0.2	0.4	-0.6	0.2	0.4	0.4	-0.6	0.0
Severe depression (siblings)	0.7	0.8	3.5	0.0	0.8	0.5	0.3	-0.5	1.9
Pack years adult smoking proportion	0.5	0.8	1.2	-0.9	0.8	1.1	1.0	0.2	1.0
Impedance of leg (right)	0.3	1.3	2.8	-1.7	0.7	0.7	1.0	0.9	1.4
Leg fat-free mass (left)	0.8	4.2	10.0	2.2	-1.8	-1.9	-1.9	0.1	-3.2
Trunk fat percentage	0.1	0.2	1.0	0.0	-0.4	0.1	0.2	-0.3	-1.0
Hand grip strength (right)	0.2	0.6	1.2	0.7	-0.6	-0.9	-1.1	0.9	-0.1
Townsend deprivation index at recruitment	0.6	0.9	2.8	-0.2	0.6	0.9	0.7	-0.9	1.7
Current tobacco smoking	0.2	0.3	0.6	-0.5	0.5	0.7	0.5	0.5	0.6
Average weekly fortified wine intake	3.8	4.5	6.1	2.0	-2.5	-2.2	-2.3	-2.4	-1.0
Maternal smoking around birth	3.5	5.0	5.9	-2.2	2.4	2.4	2.3	2.4	1.7
Fed-up feelings	0.1	0.3	0.5	-0.7	0.6	0.5	0.7	0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	5.8	-2.1	2.2	2.4	2.4	1.1	1.0
Relative age voice broke	1.8	2.7	3.7	-1.9	1.6	1.5	1.6	1.5	1.7
Taking other prescription medications	0.7	1.0	1.6	1.2	-1.3	-0.9	-1.0	-1.0	-0.3
Age when periods started (menarche)	0.5	1.1	2.0	0.7	-1.2	-1.0	-1.2	-0.7	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	-0.6	-0.1	0.5	0.6	0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.2	-1.0	1.1	1.1	1.0	0.7	1.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	-1.3	0.9	1.1	1.2	0.6	0.1
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.0	-0.2	-0.3	-0.3	-0.3	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.5	-0.4	-0.5	-0.3	-0.1	-0.8
High blood pressure	1.0	2.7	7.5	1.5	-1.6	-1.4	-1.1	-1.0	-2.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.1	0.4	-0.0	-0.2	-0.4	-0.1	1.0
Multivitamins +/- minerals	0.8	1.0	2.2	1.3	-0.5	-0.9	-1.1	-1.5	-0.2
Stomach or abdominal pain in last month	4.5	5.5	8.9	3.0	-2.2	-2.4	-2.3	-2.4	-1.7
Supplements: Glucosamine	1.5	2.0	2.7	1.5	-1.2	-1.5	-1.6	-0.6	-1.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.9	0.1	0.3	0.2	0.1	0.2	0.9
Medication: Atenolol	0.9	1.1	1.6	0.8	-1.2	-1.1	-1.0	-1.2	-0.8
Medication: Levothyroxine sodium	2.6	4.5	6.5	2.2	-2.5	-2.4	-2.6	-1.5	-1.1
Sitting height	0.7	5.3	9.2	2.2	-1.8	-2.4	-2.5	1.5	-3.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.7	-0.0	-0.2	-0.3	0.2	0.3
High blood pressure (mother)	0.2	0.3	0.5	-0.3	0.6	0.7	0.6	-0.4	0.7
Body mass index (BMI)	0.1	0.3	0.8	0.1	-0.1	0.3	0.4	-0.9	-0.9
Impedance of leg (left)	0.3	1.5	2.6	-1.6	0.7	0.8	1.0	1.4	1.5
Leg predicted mass (left)	0.8	4.4	10.5	2.2	-1.9	-1.9	-2.0	0.0	-3.2
Trunk fat mass	0.3	1.1	4.3	0.7	-1.0	-0.6	-0.5	-0.3	-2.1
Waist circumference	0.4	1.5	4.7	1.1	-1.1	-0.9	-0.7	-0.7	-2.2
Number of incorrect matches in round	0.5	0.9	3.3	0.2	-0.9	-0.8	-0.5	-0.4	-1.8
Past tobacco smoking	0.2	0.4	2.0	-0.2	0.5	0.4	0.3	0.3	1.4
Alcohol usually taken with meals	0.7	1.2	2.4	1.5	-0.7	-1.1	-1.4	-0.9	0.3
Nervous feelings	0.1	0.2	0.4	0.3	-0.3	-0.6	-0.6	0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.6	-0.6	-0.6	-0.5	-1.0	-0.9
Hearing difficulty/problems with background noise	0.8	1.3	4.1	1.1	-0.9	-1.0	-0.9	-2.0	-0.3
Hair/balding pattern: Pattern 2	0.9	1.1	5.9	-0.5	0.6	0.4	0.4	0.4	2.4
Had menopause	0.2	0.2	0.9	-0.2	0.1	0.5	0.5	0.3	-0.9
Had other major operations	0.8	1.0	2.2	-1.5	0.6	1.1	1.3	0.8	0.3
Forced vital capacity (FVC)	0.7	2.7	4.1	1.6	-1.2	-1.8	-2.0	1.6	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	1.6	-1.1	1.2	1.2	1.3	0.7	1.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.1	-0.3	-0.0	0.2	0.3	-1.1	0.5
Qualifications: None of the above	1.5	3.2	4.4	-2.1	1.7	2.1	2.0	1.9	0.3
Financial difficulties in last 2 years	0.8	1.0	1.4	0.9	-1.2	-1.2	-1.1	-1.0	0.7
Mouth/teeth dental problems	0.8	1.2	2.7	-0.7	1.1	0.8	0.7	1.3	1.6
Heart attack	2.1	2.7	4.2	1.5	-1.8	-1.8	-1.8	-2.1	-0.1
Allergy	0.1	0.3	0.6	-0.8	0.1	0.2	0.4	0.3	-0.8
Pain all over the body in last month	2.0	2.2	2.8	-1.7	1.4	1.4	1.5	1.4	1.4
Diabetes (self-reported)	0.6	0.9	1.3	-1.0	1.0	1.1	1.1	-0.1	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.5	-0.5	-0.4	-0.5	-0.6	0.3
Medication: Ramipril	0.1	0.1	0.1	0.3	-0.4	-0.3	-0.3	0.3	-0.3
Medication: Simvastatin	0.1	0.2	0.7	-0.5	0.0	0.4	0.4	-0.8	-0.1
Fluid intelligence score	0.2	0.4	2.0	-0.2	0.2	-0.0	0.0	-0.0	1.4
Illnesses of siblings	1.3	1.8	3.3	-1.3	1.3	1.2	1.0	1.8	1.3
Neuroticism score	0.5	1.0	1.8	1.0	-1.0	-1.0	-1.0	-1.3	-0.7
Weight	0.8	3.9	10.2	1.9	-1.9	-1.7	-1.6	-0.4	-3.2
Impedance of arm (right)	0.2	0.8	1.5	-1.2	0.7	0.6	0.7	0.9	1.2
Arm fat percentage (right)	0.1	0.4	0.9	-0.6	0.3	0.8	1.0	-0.7	-0.4
Trunk fat-free mass	0.9	5.3	12.2	2.4	-1.9	-2.2	-2.2	0.7	-3.5
Hip circumference	0.5	2.1	6.6	1.5	-1.2	-1.1	-0.9	-0.5	-2.6
Time employed in main current job	0.9	1.0	1.6	1.3	-1.1	-1.1	-1.2	-0.9	-0.2
Alcohol intake versus 10 years previously	1.3	1.9	3.8	-1.2	1.6	1.4	1.4	1.9	0.3
Father’s age at death	0.2	0.3	0.5	-0.6	0.6	0.6	0.7	-0.3	-0.4
Worrier / anxious feelings	0.1	0.1	0.4	-0.2	-0.0	-0.2	-0.1	-0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.4	0.4	-0.4	-0.3	-0.1	-1.2	-0.7
Falls in the last year	0.2	0.3	0.5	0.5	-0.6	-0.4	-0.4	-0.7	-0.4
Hair/balding pattern: Pattern 3	0.4	0.7	3.0	0.7	-0.5	-0.3	-0.3	0.1	-1.7
Number of live births	0.7	1.0	4.1	0.4	-0.9	-0.7	-0.6	-0.5	-2.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	4.8	1.7	-1.5	-2.0	-2.2	1.4	-1.8
Pulse rate	0.2	0.3	1.0	0.5	-0.5	-0.2	-0.3	-0.2	-1.0
Happiness	0.7	0.8	2.0	0.8	-0.5	-0.7	-0.6	0.9	-1.4
Noisy workplace	0.0	0.0	0.1	0.0	0.2	0.3	0.1	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.7	0.9	-0.9	-1.2	-1.3	-0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	0.6	-0.8	-0.9	-0.8	-0.4	0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.9	0.3	-0.1	0.0	0.0	-0.9	-1.4
Asthma	0.2	0.3	1.0	0.5	0.0	0.0	-0.1	-0.7	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	0.5	-0.8	-0.7	-0.5	-1.4	-0.4
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.2	0.0	0.2	0.2	-0.6	0.2
Depression (self-reported)	0.2	0.3	1.2	0.2	-0.5	-0.1	-0.0	-1.1	-0.0
Medication: Lansoprazole	0.4	0.5	1.7	0.3	-0.3	-0.2	-0.1	-1.3	-1.0
Prospective memory result	0.9	1.1	3.1	0.7	-0.8	-0.6	-0.5	-1.8	-1.4
Lung cancer (father)	0.2	0.2	0.8	-0.3	0.3	0.3	0.2	0.9	0.5
Illnesses of mother	0.7	0.9	1.5	-1.1	0.9	0.9	0.9	1.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.0	0.2	-0.2	-0.6	-0.7	1.7	-0.7
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	0.9	-0.8	-0.9	-0.8	-0.7	-1.5
Impedance of arm (left)	0.1	0.2	0.8	-0.7	0.0	0.0	0.1	-0.3	0.9
Arm fat mass (right)	0.1	0.4	2.0	0.4	-0.4	-0.1	0.0	-0.4	-1.4
Trunk predicted mass	0.9	5.3	12.5	2.4	-1.9	-2.2	-2.2	0.7	-3.5
Standing height	1.5	14.9	26.7	3.7	-3.6	-4.1	-4.2	1.3	-5.2
Length of working week for main job	0.5	0.6	1.5	-0.4	0.8	0.5	0.5	0.8	1.2
Exposure to tobacco smoke at home	2.1	2.4	3.0	1.5	-1.7	-1.7	-1.7	-1.0	-1.4
Breastfed as a baby	0.0	0.1	0.1	-0.2	0.3	0.3	0.3	-0.1	0.2
Tense / ‘highly strung’	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.3	0.1	0.5	0.5	-1.1	-0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.2	-0.2
Birth weight of first child	0.4	0.7	1.6	1.3	-0.6	-0.8	-0.9	-0.3	-0.6
Peak expiratory flow (PEF)	0.1	0.3	1.7	0.2	0.1	-0.2	-0.3	1.3	0.3
Pulse wave reflection index	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.3	0.1	-0.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.0	0.5	-0.9	-0.7	-0.5	-1.7	-0.6
Loud music exposure frequency	6.3	6.8	9.3	-2.7	3.0	3.0	3.0	2.5	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.0	-0.1	-0.4	-0.2	-0.3	0.5
Mouth/teeth dental problems: Bleeding gums	2.4	3.2	4.2	1.2	-2.0	-2.0	-1.8	-1.9	-1.6
Blood clot in the leg (DVT)	1.7	2.1	3.6	-1.6	1.6	1.9	1.9	0.5	0.6
Medication: Paracetamol	0.5	0.8	1.7	-0.8	1.0	1.1	1.3	0.2	0.5
Headache pain in last month	2.1	3.6	4.4	1.9	-2.0	-2.1	-1.8	-1.6	-2.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	0.6	-0.7	-1.0	-1.0	-0.2	-0.2
Glaucoma (self-reported)	2.1	2.5	3.5	-1.2	1.6	1.6	1.5	1.7	1.9
Gout (self-reported)	1.3	1.8	3.8	1.9	-1.1	-1.5	-1.7	-0.9	0.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.3	1.3	-1.8	-1.7	-1.7	-1.0	-1.3
Medication: Amlodipine	2.3	3.2	3.6	1.8	-1.9	-1.8	-1.7	-1.9	-1.8
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.5	0.1	0.1	-0.1	-0.1	0.7
Birth weight	2.4	5.2	7.0	2.5	-2.4	-2.5	-2.6	-1.5	-1.9
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.7	1.9	-1.2	-1.3	-1.5	-0.7	-0.4
High blood pressure (siblings)	0.0	0.1	0.1	0.2	-0.4	-0.2	-0.1	-0.3	0.3
Forced vital capacity (FVC), Best measure	0.3	1.2	3.3	0.8	-0.5	-1.1	-1.2	1.8	-0.7
Body fat percentage	0.1	0.3	1.1	-0.1	-0.3	0.2	0.4	-0.5	-1.1
Leg fat percentage (right)	0.1	0.4	0.9	-0.5	0.1	0.6	0.8	-0.6	-0.9
Arm fat-free mass (right)	0.9	4.8	11.5	2.2	-1.9	-2.0	-2.1	0.7	-3.4
Exposure to tobacco smoke outside home	2.3	3.1	5.1	1.9	-1.7	-1.7	-1.7	-2.2	-1.1
Comparative body size at age 10	0.8	2.1	3.2	1.7	-1.2	-1.4	-1.4	-1.8	-1.0
Number of full brothers	0.4	0.5	1.1	0.2	-0.9	-0.7	-0.7	-1.0	-0.4
Worry too long after embarrassment	0.1	0.2	0.4	0.6	-0.2	-0.6	-0.6	-0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.2	-1.0	0.6	0.8	0.8	-0.2	1.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.7	0.3	-0.1	0.0	-0.1	-1.5	1.7
Number of children fathered	0.2	0.3	0.6	-0.2	-0.4	-0.4	-0.4	-0.7	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.8	-0.7	1.3	1.2	1.0	0.7	2.0
Age at first live birth	2.1	3.7	5.8	1.8	-2.0	-2.2	-2.1	-2.4	0.3
Pulse wave peak to peak time	0.4	0.5	1.2	-0.7	0.5	0.6	0.6	0.7	1.1
Health satisfaction	2.6	3.3	4.1	1.9	-2.0	-1.9	-1.8	-1.4	-1.8
Shortness of breath walking on level ground	0.3	0.4	1.2	0.5	-0.8	-0.5	-0.4	-1.1	-0.1
Qualifications: College or University degree	1.0	3.3	5.1	1.9	-1.7	-2.0	-2.0	-2.3	0.2
Eye problems/disorders: None of the above	0.1	0.2	0.6	0.2	-0.1	-0.3	-0.4	-0.8	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	0.7	-0.7	-0.4	-0.6	-1.3	-0.4
Emphysema/chronic bronchitis	0.7	0.7	1.3	1.0	-0.7	-0.7	-0.8	-1.2	-0.7
Medication for pain relief, constipation, heartburn	1.2	2.0	3.8	-1.5	1.5	1.4	1.2	2.0	0.7
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.2	0.2	0.2	0.3	-0.1	0.1
Medication: Blood pressure	0.2	0.4	2.1	0.0	-0.1	0.2	0.3	0.0	-1.4
Angina (self-reported)	1.7	2.3	3.7	1.9	-1.3	-1.4	-1.6	-1.9	0.1
Migraine (self-reported)	0.2	0.2	0.5	-0.0	-0.7	-0.5	-0.5	-0.4	0.2
Medication: Ibuprofen	0.3	0.4	1.1	-0.1	-0.6	-0.5	-0.2	-0.9	-1.0
Medication: Allopurinol	1.6	2.2	4.5	2.1	-1.4	-1.7	-1.9	-0.7	0.0
Medication: Omeprazole	0.4	0.5	1.5	0.9	-0.4	-0.3	-0.5	-1.2	0.4
Medication: Seretide 50 evohaler	0.2	0.3	1.0	0.6	-0.4	-0.3	-0.2	-0.0	-1.0
Mean time to correctly identify matches	4.8	9.2	12.7	3.4	-3.5	-3.2	-3.6	-2.2	-1.6
Heart disease (mother)	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.2	-0.0	-0.1	-0.1	0.1	0.1	-0.5
Whole body fat mass	0.2	1.0	3.6	0.7	-0.9	-0.6	-0.5	-0.4	-1.9
Leg fat mass (right)	0.2	0.7	3.2	0.3	-0.6	-0.2	0.0	-0.5	-1.8
Arm predicted mass (right)	1.0	5.0	11.4	2.3	-2.0	-2.1	-2.1	0.5	-3.4
Pulse rate, automated reading	0.0	0.1	0.3	0.3	-0.1	0.1	0.2	-0.2	-0.5
Alcohol intake frequency.	0.1	0.3	1.0	0.0	-0.3	-0.2	0.0	-0.9	-1.0
Comparative height size at age 10	1.7	9.2	16.1	2.8	-2.9	-3.3	-3.4	1.0	-4.0
Number of full sisters	1.1	1.3	3.3	-0.6	1.2	0.7	0.6	1.3	1.8
Suffer from ‘nerves’	0.1	0.2	0.7	-0.3	0.4	0.4	0.3	0.2	0.8
Overall health rating	0.2	0.5	1.1	0.7	-0.8	-0.6	-0.4	-1.0	-0.5
Chest pain or discomfort	0.5	0.7	1.7	0.6	-0.8	-0.8	-0.6	-0.6	-1.3
Had major operations	2.4	2.8	3.8	-1.9	1.8	1.9	1.9	0.7	1.4
Age at last live birth	2.2	3.2	4.4	1.6	-1.9	-2.1	-2.0	-2.1	-0.5
Family relationship satisfaction	0.0	0.0	0.1	0.1	0.1	0.2	0.1	-0.2	0.3
Leg pain on walking	0.2	0.3	1.1	-0.1	-0.1	0.2	0.2	-1.0	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.2	-0.1	-0.4	-0.1	0.0	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.3	-1.5	0.9	1.1	1.4	0.9	-0.4
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	3.2	-1.4	1.7	1.8	1.6	1.1	0.7
Medication: Aspirin	2.3	3.0	4.0	2.0	-1.9	-1.9	-1.8	-1.9	-0.7
Supplements: Vitamin C	0.0	0.0	0.1	-0.1	0.2	0.3	0.2	-0.0	0.2
Knee pain experienced in last month	2.6	4.1	5.6	2.2	-2.2	-2.4	-2.3	-1.6	-1.2
Hypertension (Self-reported)	1.4	3.9	9.5	1.8	-2.0	-1.8	-1.5	-1.3	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.7	0.7	-1.4	-1.1	-1.0	-0.9	-2.4
Illnesses of father: Heart disease	0.6	0.8	1.6	-1.1	0.7	0.8	0.7	1.3	0.6
Illnesses of siblings: Diabetes	0.4	0.4	2.1	0.1	0.2	0.1	0.3	-0.6	-1.5
Smoking status: Previous	0.6	0.9	3.3	0.4	-0.9	-0.8	-0.5	-0.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.9	-0.4	-0.0	-0.3	-0.2	1.0	-0.8
Whole body fat-free mass	0.9	5.0	11.5	2.4	-1.9	-2.1	-2.2	0.7	-3.4
Leg fat-free mass (right)	0.9	4.7	10.2	2.4	-1.9	-2.0	-2.1	0.3	-3.2
Arm fat percentage (left)	0.1	0.4	1.5	-0.2	-0.1	0.4	0.6	-1.2	-0.7
Average weekly red wine intake	0.1	0.1	0.4	-0.3	0.5	0.2	0.2	0.6	0.3
Handedness (chirality/laterality): Left-handed	1.3	1.5	2.3	-1.0	1.4	1.2	1.2	0.9	1.5
Mood swings	1.7	3.1	5.9	1.4	-1.6	-1.5	-1.4	-2.4	-1.9
Loneliness, isolation	1.9	2.6	3.0	-1.7	1.5	1.7	1.7	1.3	1.7
Long-standing illness, disability or infirmity	0.5	0.8	1.5	1.2	-0.9	-1.1	-1.0	0.1	-0.5
Ever had bowel cancer screening	1.6	1.9	2.9	1.7	-1.1	-1.3	-1.4	-0.8	-1.6
Diabetes diagnosed by doctor	0.2	0.2	0.5	-0.4	0.5	0.5	0.6	-0.7	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.6	-0.0	0.3	0.1	0.3	-0.8	0.1
Friendships satisfaction	2.0	2.5	3.2	1.8	-1.8	-1.8	-1.8	-0.9	-1.2
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.1	0.1	-0.1	0.1	0.6	-0.3
Commuting to job workplace: Walk	3.1	3.3	5.3	2.3	-1.6	-1.6	-1.9	-2.2	0.8
Eye problems/disorders: Cataract	0.2	0.3	1.4	0.1	-0.2	0.0	0.1	0.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.6	-1.7	1.7	1.7	1.9	0.5	0.5
Medication for cholesterol	3.2	4.9	6.8	-2.6	2.5	2.5	2.4	1.0	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	1.8	0.8	-1.2	-1.1	-1.1	-1.1	-1.4
Back pain experienced in last month	1.3	1.9	2.9	1.3	-1.7	-1.4	-1.3	-1.1	-1.4
Mineral and other dietary supplements	1.0	1.3	2.4	-1.0	1.0	1.0	1.0	1.5	1.2
Breast cancer (self-reported)	0.3	0.4	0.9	-0.8	0.4	0.8	0.9	0.0	-0.0
Asthma (self-reported)	0.2	0.5	1.3	0.7	-0.1	-0.2	-0.3	-1.1	0.9
Osteoporosis (self-reported)	0.6	0.8	1.5	0.4	-1.2	-0.7	-0.7	-1.2	-0.8
Osteoarthritis (self-reported)	0.1	0.2	0.6	-0.5	0.1	0.1	0.1	0.8	-0.3
Medication: Aspirin	1.6	2.1	2.8	1.7	-1.6	-1.6	-1.6	-1.4	-0.4
Medication: Gliclazide	0.7	0.8	1.2	-0.9	1.1	1.1	1.0	0.7	-0.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	0.1	-0.1	0.0	0.1	-0.6	-0.9
Smoking status: Current	0.3	0.5	0.9	-0.6	0.6	0.9	0.6	0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	0.9	-0.3	-0.5	-0.9	-0.3	0.1
Whole body water mass	0.9	5.3	11.9	2.5	-2.0	-2.2	-2.2	0.6	-3.5
Leg predicted mass (right)	0.8	4.3	9.5	2.4	-1.8	-1.9	-2.0	0.3	-3.1
Arm fat mass (left)	0.2	0.7	2.6	0.5	-0.6	-0.2	-0.1	-0.8	-1.6
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	0.9	-0.9	-0.7	-0.6	-0.5	-1.4
Average weekly champagne plus white wine intake	1.8	2.5	4.0	2.0	-1.7	-1.8	-2.0	-0.9	0.0
Miserableness	0.1	0.3	1.4	-0.0	-0.1	-0.1	0.1	-0.4	-1.2
Guilty feelings	0.6	0.9	3.5	0.8	-0.6	-0.8	-0.7	-1.9	-0.1
Wears glasses or contact lenses	0.9	1.1	2.6	1.6	-0.9	-0.9	-1.1	-0.8	-0.4
Ever taken oral contraceptive pill	0.2	0.2	1.1	-0.5	-0.2	-0.0	0.2	-1.0	-0.2
Hearing aid user	2.0	2.3	6.0	-1.4	1.5	1.3	1.4	0.3	2.5
Mother’s age at death	0.1	0.2	0.9	0.3	-0.1	-0.1	-0.0	-0.3	-0.9
Financial situation satisfaction	0.1	0.2	0.3	-0.5	0.2	0.5	0.4	-0.4	0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.2	-0.2	-0.1	-0.2	0.5	0.1
Commuting to job workplace: Public transport	0.3	0.3	1.1	0.5	-0.2	-0.2	-0.5	-0.3	1.1
Eye problems/disorders: Glaucoma	1.0	1.2	2.8	-0.6	1.0	1.0	0.9	1.2	1.7
Medication: Blood pressure	1.2	2.2	3.3	1.6	-1.6	-1.6	-1.5	-0.5	-1.8
Pain type(s) experienced in last month: Hip pain	2.0	2.5	3.6	1.8	-1.9	-1.8	-1.7	-1.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	0.7	-0.5	-0.5	-0.7	-1.1	0.5
High cholesterol (Self-reported)	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.2	-0.6	-0.1
Medication: Bendroflumethiazide	0.1	0.1	0.5	0.7	-0.1	0.1	-0.1	-0.1	0.0
Medication: Paracetamol	1.2	1.9	3.4	-1.6	1.4	1.5	1.8	0.9	0.6
Medication: Lisinopril	0.1	0.1	0.2	0.0	-0.4	-0.2	-0.0	-0.5	-0.1
Medication: Atorvastatin	0.4	0.4	0.6	0.6	-0.7	-0.7	-0.6	-0.6	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.8	0.2	-0.5	-0.3	-0.2	-0.9	0.0
Alcohol drinker status: Never	0.5	0.6	3.2	-0.1	-0.4	-0.3	-0.1	-1.8	0.2
Ever smoked	0.3	0.4	1.5	-0.5	0.4	0.5	0.6	0.4	-1.2
Basal metabolic rate	0.9	5.0	11.6	2.4	-2.0	-2.1	-2.1	0.4	-3.4
Leg fat percentage (left)	0.1	0.4	0.7	-0.5	0.1	0.6	0.8	-0.4	-0.9
Arm fat-free mass (left)	0.9	4.5	11.8	2.1	-1.7	-1.8	-1.8	1.1	-3.4
Number of operations (self-reported)	4.2	6.2	9.7	-2.7	2.6	3.1	3.1	0.9	1.8
Average weekly beer plus cider intake	5.0	7.2	10.3	-3.2	2.8	2.9	3.0	1.7	2.4
Irritability	0.4	0.7	3.1	0.1	-0.6	-0.5	-0.2	-1.8	-0.6
Risk taking	0.3	0.5	2.0	0.1	-0.4	-0.4	-0.5	-0.5	1.4
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.1	-0.7	1.0	1.1	1.0	-0.2	0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.2	-0.4	-0.6	-0.6	1.0	-0.0
Age started oral contraceptive pill	0.0	0.1	0.2	-0.2	-0.1	0.2	0.2	0.2	-0.4
Diastolic blood pressure, automated reading	0.3	1.0	4.2	-0.1	0.6	0.4	0.5	2.0	-0.9
Ever depressed for a whole week	0.4	0.5	0.8	0.9	-0.7	-0.7	-0.8	-0.6	-0.1
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.6	0.7	0.8	1.0	-0.1	0.1
Commuting to job workplace: Cycle	1.0	1.3	2.7	-1.0	1.2	1.0	0.6	1.1	1.6
Myopia	0.4	0.6	0.9	0.8	-0.7	-0.9	-1.0	-0.5	-0.5
Vascular/heart problems diagnosed by doctor	1.4	3.9	5.2	-2.1	2.1	1.9	1.7	1.8	2.3
Cholesterol lowering medication	0.9	1.3	1.9	1.4	-1.3	-1.0	-1.2	-0.9	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.6	-0.3	-0.1	-0.3	-0.8	0.2
Pain experienced in last month	1.6	2.7	3.6	-1.8	1.9	1.9	1.6	1.2	1.2
Supplements: Calcium	1.0	1.1	2.1	0.9	-1.1	-0.8	-0.7	-1.2	-1.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	1.0	-1.0	-1.0	-0.8	-0.6	-1.7
Heart attack/myocardial infarction (self-reported)	2.7	3.5	5.1	1.8	-2.0	-2.0	-2.1	-2.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.6	-1.3	1.4	1.6	1.6	0.3	0.4
Heart disease (siblings)	4.6	5.6	7.2	2.7	-2.4	-2.7	-2.6	-2.5	-0.8
Alcohol drinker status: Previous	0.7	0.8	0.9	0.9	-1.0	-0.8	-0.7	-0.8	-1.0
Pack years of smoking	0.7	1.1	1.6	-0.9	1.0	1.3	1.2	0.4	1.1
Impedance of whole body	0.1	0.6	1.5	-1.2	0.3	0.4	0.5	0.4	1.2
Leg fat mass (left)	0.1	0.5	2.7	0.3	-0.6	-0.1	0.0	-0.3	-1.6
Arm predicted mass (left)	0.9	4.4	10.9	2.2	-1.8	-1.8	-1.9	0.8	-3.3