TWAS hub - AK3P3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2700	0.0930	5.8e-04	0.150	NA	0.135	NA	0.116	3.5e-05	NA	8.4e-05	NA	2.8e-04
2	GTEx	Heart Left Ventricle	0.1122	0.0488	4.9e-03	-0.002	NA	-0.005	NA	-0.002	4.1e-01	NA	9.4e-01	NA	4.2e-01
3	GTEx	Muscle Skeletal	0.0514	0.0225	4.3e-03	0.004	NA	0.005	NA	0.001	1.3e-01	NA	9.9e-02	NA	2.5e-01
4	GTEx	Nerve Tibial	0.0966	0.0381	2.3e-04	0.060	NA	0.029	NA	0.027	4.5e-05	NA	3.7e-03	NA	5.0e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.0764	0.0237	2.5e-08	0.083	0.069	0.079	0.072	0.077	8.4e-11	3.6e-09	2.2e-10	1.3e-09	4.4e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Supplements: Vitamin C	5.1	6.0	9.3	-2.6	-2.8	-1.9	-1.6	-3.0
Current tobacco smoking	4.6	7.5	15.2	-3.0	-2.6	-0.3	-3.9	-2.6
Mean time to correctly identify matches	4.3	8.2	13.4	-3.7	-1.3	-2.0	-3.3	-3.3
Smoking status: Current	4.1	6.5	13.0	-3.0	-2.2	-0.2	-3.6	-2.3
Vitamin and mineral supplements	3.8	5.1	6.6	2.5	1.8	2.4	1.8	2.6
Number of operations (self-reported)	3.8	5.7	12.6	-3.6	-1.2	-1.6	-2.8	-2.0
Basal cell carcinoma (self-reported)	3.7	4.4	7.1	2.2	2.2	0.6	2.2	2.7
Hand grip strength (left)	3.6	9.4	24.2	3.7	0.8	4.9	1.0	2.7
Hand grip strength (right)	3.6	9.8	19.6	4.0	1.5	4.4	1.7	2.9
Had major operations	3.5	4.1	9.4	-3.1	-1.9	-1.3	-1.9	-1.5
Breast cancer (self-reported)	3.5	4.2	9.6	1.8	3.1	-0.2	0.6	2.8
Triglycerides	3.3	5.3	10.2	1.8	3.2	0.4	2.0	3.0
Severe depression (siblings)	3.3	3.7	5.2	-2.3	-1.9	-1.9	-1.1	-2.1
Wears glasses or contact lenses	3.3	3.8	9.6	-1.5	-1.4	-1.6	-1.5	-3.1
Birth weight	3.1	6.7	17.1	3.7	-0.4	4.1	1.4	0.6
Reaction Time	3.0	5.7	9.5	-3.1	-1.3	-1.0	-2.9	-2.8
Sensitivity / hurt feelings	2.9	5.0	9.0	-3.0	-1.7	-2.7	-1.6	-1.8
Stomach or abdominal pain in last month	2.8	3.5	13.0	-0.8	-1.6	-3.6	0.4	-1.0
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	5.5	2.3	2.1	1.1	2.2	2.4
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	5.9	-2.4	-0.8	-1.5	-1.1	-2.4
Shortness of breath walking on level ground	2.6	3.1	5.9	1.0	1.6	-1.3	2.4	2.1
Schizophrenia (2014)	2.5	5.6	15.6	0.9	2.3	-3.9	2.3	1.1
Commuting to job workplace: Walk	2.5	2.7	4.2	-1.8	-1.6	-1.2	-2.0	-1.4
Chronic bronchitis/emphysema (father)	2.4	2.8	4.4	1.7	2.1	0.6	1.9	1.7
Back pain experienced in last month	2.4	3.5	5.7	1.7	1.6	1.5	2.4	2.1
Glaucoma (self-reported)	2.3	2.7	5.3	-1.9	-2.3	0.4	-1.6	-1.5
Migraine (self-reported)	2.3	2.8	4.7	2.0	0.5	2.2	1.3	1.8
Smoking Status	2.1	5.0	9.4	-3.1	-1.8	0.0	-3.0	-1.8
Medication: Co-codamol	2.1	2.4	5.2	-0.9	-1.3	-0.8	-1.9	-2.3
Exposure to tobacco smoke at home	2.1	2.4	2.8	1.6	1.7	1.4	1.5	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	5.2	-2.3	-2.0	0.3	-1.5	-1.4
Neuroticism (Nagel 2018)	2.0	4.8	11.3	-2.6	-0.7	-3.4	-1.0	-2.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	3.6	-1.9	-0.3	-1.0	-1.6	-1.9
Hearing difficulty/problems with background noise	2.0	3.1	11.5	-1.7	0.2	-3.4	0.1	-1.1
Depressed Affect (Nagel 2018)	1.8	3.8	6.1	-2.5	-0.6	-2.4	-1.2	-2.3
Schizophrenia vs Biploar Disorder	1.8	2.3	5.2	0.3	1.6	-2.3	1.7	0.7
Major Depression (MDD)	1.8	2.2	6.8	-1.5	-0.6	-2.6	1.2	-0.4
Medication: Ventolin 100micrograms inhaler	1.8	2.3	8.7	-1.0	-0.5	-0.6	-1.0	-3.0
Ever smoked	1.8	3.2	8.5	-2.9	-1.2	-0.3	-2.0	-1.4
Average weekly beer plus cider intake	1.8	2.6	4.1	-2.0	-1.5	-1.6	-1.9	-0.8
Commuting to job workplace: Public transport	1.7	2.1	3.8	-1.8	-0.4	-1.9	-0.8	-1.6
Schizophrenia (2018)	1.6	3.3	6.2	1.4	1.3	-2.5	2.3	1.2
Number of incorrect matches in round	1.6	2.7	5.2	1.7	1.5	0.1	2.3	1.9
Hair/balding pattern: Pattern 2	1.6	2.1	6.8	-0.9	-2.6	0.3	-1.4	-0.9
Had other major operations	1.6	1.9	4.1	-2.0	-0.5	-1.2	-1.9	-0.6
Mood swings	1.6	2.9	6.3	-2.0	-0.8	-2.5	-0.9	-1.6
Alcohol drinker status: Never	1.6	1.9	2.5	-1.4	-1.1	-1.5	-1.3	-1.6
Ever had prostate specific antigen (PSA) test	1.6	1.9	5.5	-1.0	-1.0	-2.4	-0.6	-1.2
Blood Eosinophil Count	1.4	10.7	32.5	-5.7	-0.4	-4.5	-1.0	-0.3
Blood White Count	1.4	10.1	32.0	-5.7	-1.4	-2.7	-2.8	-1.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.1	-1.5	-0.3	-1.8	-1.3	-1.2
Medication: Seretide 50 evohaler	1.4	1.6	3.6	-0.3	0.6	-1.6	-1.1	-1.9
Qualifications: nursing, teaching	1.4	2.2	3.6	-1.9	-1.3	-1.7	-1.3	-1.1
Mineral and other dietary supplements	1.4	1.9	4.0	1.2	0.2	2.0	0.5	1.9
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.1	-1.2	-0.4	-1.6	-1.0	-2.0
Diabetes (father)	1.3	1.6	2.4	0.7	1.6	-1.1	1.1	1.6
Age when periods started (menarche)	1.3	3.1	7.5	-0.8	-2.7	0.8	-1.9	-1.7
Noisy workplace	1.3	1.6	2.9	-1.0	-0.7	-1.7	-1.1	-1.5
Depression (self-reported)	1.3	1.6	3.2	-1.8	0.2	-1.5	-1.5	-0.4
Peak expiratory flow (PEF)	1.3	3.0	5.2	-0.9	-0.1	2.3	-2.2	-2.0
Pulse rate, automated reading	1.3	4.3	8.5	2.6	1.4	-0.4	2.0	2.9
Risk taking	1.3	1.9	3.6	-1.5	-1.9	0.6	-1.2	-1.4
Systolic Blood Pressure	1.2	5.8	12.0	0.7	2.9	-0.7	3.5	2.8
Neuroticism	1.2	3.0	5.0	-2.1	-1.4	-2.2	-1.0	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	16.2	1.6	0.5	4.0	-0.1	-0.0
Loud music exposure frequency	1.2	1.3	2.8	-1.7	0.1	-0.6	-1.2	-1.4
Forced vital capacity (FVC), Best measure	1.2	4.3	15.7	2.3	0.6	4.0	0.4	-0.3
Age at first live birth	1.2	2.2	3.4	1.3	1.7	-1.0	1.5	1.9
Neck or shoulder pain in last month	1.2	1.8	2.6	1.4	0.8	1.5	1.2	1.6
Miserableness	1.2	2.1	4.5	-1.7	-0.9	-0.7	-2.1	-1.4
Bipolar Disorder or Schizophrenia	1.1	2.7	7.1	1.3	0.9	-2.7	1.8	0.9
Lupus	1.1	1.6	3.8	1.5	-0.1	2.0	0.5	1.3
Height	1.1	21.0	57.3	5.5	3.4	7.6	2.1	1.2
Diabetes (mother)	1.1	1.5	2.8	1.7	0.3	1.6	-1.0	0.8
Number of live births	1.1	1.5	3.8	-1.1	-0.6	0.4	-1.5	-2.0
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	14.2	1.4	-0.0	3.8	-0.9	-1.1
Tense / ‘highly strung’	1.1	1.8	3.2	-1.8	-1.1	-1.8	-0.9	-0.8
Heart disease (mother)	1.1	1.3	2.6	1.1	1.2	1.6	0.5	0.9
Comparative height size at age 10	1.1	6.1	16.6	2.3	2.1	4.1	1.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	8.1	1.2	1.2	2.8	0.6	0.6
Average weekly champagne plus white wine intake	1.1	1.5	4.9	1.2	-0.3	0.4	2.2	0.9
Guilty feelings	1.1	1.7	6.1	-1.1	-0.1	-2.5	0.5	-0.9
Allergy or Eczema	1.0	2.5	6.7	-0.9	-1.1	-0.5	-1.9	-2.6
Average weekly spirits intake	1.0	1.2	2.2	-1.1	-0.9	-0.8	-1.1	-1.5
Townsend deprivation index at recruitment	1.0	1.4	3.8	-1.0	-1.1	-1.9	-0.6	-0.8
High blood pressure	1.0	2.8	5.8	1.0	2.4	-1.9	1.4	1.1
Standing height	1.0	10.0	33.8	3.5	1.5	5.8	1.1	0.8
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	2.5	-1.6	1.1	-1.3	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.4	-1.1	-1.8	-0.3	-1.2	0.1
Osteoporosis (self-reported)	1.0	1.2	2.2	-1.3	-1.2	-0.3	-0.6	-1.5
Illnesses of father: None of the above (group 1)	1.0	1.2	2.4	-1.6	-0.9	-1.3	-0.5	-0.9
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.8	-0.5	-2.2	2.6	-1.1	-0.7
Heart disease (siblings)	1.0	1.3	4.5	1.0	0.6	-0.5	2.1	0.6
Depression (Nagel 2018)	0.9	1.3	4.8	-1.1	-0.6	-2.2	-0.0	-0.3
Age at First Birth	0.9	1.4	2.3	0.9	1.5	-0.0	1.2	1.5
Crohns Disease (2012)	0.9	1.4	2.8	0.8	1.2	0.2	1.5	1.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.5	-1.0	1.2	-1.2	-0.9	-0.8
Systolic blood pressure, automated reading	0.9	2.7	4.7	1.0	2.0	-0.4	1.9	2.2
Sitting height	0.9	6.4	17.3	3.1	1.5	4.2	1.2	1.0
Forced vital capacity (FVC)	0.9	3.6	12.4	1.5	-0.2	3.5	-0.8	-1.7
Mouth/teeth dental problems	0.9	1.3	3.6	1.9	0.1	1.1	1.0	0.9
Medication: Lansoprazole	0.9	1.0	1.8	-1.0	0.3	-1.4	0.8	1.1
Illnesses of mother	0.9	1.1	2.2	1.0	1.5	0.8	0.6	1.2
Breastfed as a baby	0.9	1.1	2.9	-1.7	0.5	-1.3	-0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.9	1.0	5.0	-0.3	-0.2	-2.2	0.2	0.3
Gout (self-reported)	0.9	1.3	2.7	-0.9	-0.9	-1.0	-1.6	-1.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.8	0.5	-1.7	-1.0	0.8	-0.5
Worry too long after embarrassment	0.9	1.4	3.7	-0.9	0.1	-1.9	-1.1	-1.2
Angina (self-reported)	0.9	1.2	2.3	-1.4	1.0	-1.5	-0.2	-0.8
Age at last live birth	0.9	1.3	2.5	1.3	1.0	0.0	1.2	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.4	0.7	0.0	1.9	-1.2	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	1.6	1.2	1.1	-1.3	0.8	0.8
Hearing aid user	0.9	1.0	3.3	-1.8	-0.3	-1.2	-0.4	-0.2
Eye problems/disorders: Glaucoma	0.9	1.0	3.0	-1.2	-1.7	0.3	-0.6	-0.4
Medication: Paracetamol	0.9	1.4	4.2	-1.2	2.0	-0.0	-1.0	-0.3
Fractured/broken bones in last 5 years	0.9	1.2	3.1	0.7	1.5	1.8	0.1	0.2
Worry (Nagel 2018)	0.8	1.7	4.7	-1.4	-0.3	-2.2	0.1	-1.3
Body Mass Index (BMI) (2010)	0.8	1.1	2.0	-1.0	-0.8	-0.8	-1.4	-1.0
Coronary Artery Disease (CAD)	0.8	1.0	2.3	-1.5	-0.4	-1.4	-0.6	-0.5
BMI	0.8	4.9	7.5	-2.4	-1.2	-2.7	-2.6	-1.8
Angina	0.8	1.0	1.8	-1.3	0.9	-1.3	-0.1	-0.8
Impedance of leg (left)	0.8	4.0	13.2	1.2	0.8	3.6	1.1	1.9
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.6	-1.3	0.3	-1.1	-1.1	-0.8
Illnesses of siblings	0.8	1.1	4.1	0.9	-0.5	2.0	-0.7	-0.0
Birth weight of first child	0.8	1.5	4.3	0.9	-2.1	1.3	-0.2	-0.9
Wheeze or whistling in the chest in last year	0.8	1.4	2.6	-1.2	-1.6	-0.0	-1.2	-1.2
Medication: Ibuprofen	0.8	0.9	3.6	-0.2	1.9	-0.4	-0.4	-0.9
Hypertension (Self-reported)	0.8	2.2	4.7	0.6	2.2	-2.1	1.2	0.6
Arm fat percentage (left)	0.8	3.1	7.8	-2.8	-0.6	-2.3	-1.1	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.2	0.1	-0.0	0.0	1.4	1.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	-1.5	-0.7	-0.8	-0.9	-0.9
HbA1C	0.7	0.8	1.4	1.2	0.7	-0.4	1.1	0.8
HDL Cholesterol	0.7	1.2	4.6	0.9	-2.2	-0.3	0.4	-0.5
Rheumatoid Arthritis	0.7	0.9	2.1	-0.7	-1.5	-0.1	-0.1	-1.4
Waist Hip Ratio (WHR)	0.7	3.0	8.8	0.9	-0.4	3.0	0.7	2.1
Lung FEV1/FVC ratio	0.7	3.5	8.5	-2.3	-1.1	1.2	-2.9	-1.0
Impedance of leg (right)	0.7	3.6	12.5	0.7	0.6	3.5	1.1	1.9
Maternal smoking around birth	0.7	1.0	1.5	0.7	0.9	1.2	0.9	1.1
Multivitamins +/- minerals	0.7	0.9	1.4	-1.2	-0.6	-1.2	-0.8	-0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.2	-0.9	-0.4	-1.5	-0.1	-0.8
Arm fat percentage (right)	0.7	2.8	8.2	-2.9	-0.7	-2.0	-1.0	-0.7
Father’s age at death	0.7	1.0	2.0	0.6	1.0	-0.4	1.2	1.4
Worrier / anxious feelings	0.7	1.3	5.1	-0.6	0.3	-2.2	0.9	-0.4
Medication: Cholesterol lowering	0.7	1.1	2.2	-1.4	-0.9	-0.5	-1.5	-0.5
Pulse wave reflection index	0.7	0.8	1.8	-0.3	-1.3	-0.5	-0.4	-1.3
Blood clot in the leg (DVT)	0.7	0.9	3.2	-0.6	-0.9	-1.8	0.4	0.2
Qualifications: College or University degree	0.7	2.2	3.6	-1.8	-0.5	-1.9	-1.1	-1.7
Eye problems/disorders: None of the above	0.7	0.8	2.1	0.2	1.0	-0.8	1.4	0.7
Emphysema/chronic bronchitis	0.7	0.8	1.0	-0.9	-1.0	-0.9	-0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.7	-1.1	0.2	0.2	-1.1	-1.3
Illnesses of father: Heart disease	0.7	1.0	2.9	-0.0	-0.7	1.7	-1.0	-0.7
Loneliness, isolation	0.7	0.9	1.8	-1.2	-0.6	0.0	-1.0	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.1	-1.8	-0.2	-0.7	-1.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.1	-0.4	-0.9	-1.8	0.4	0.2
Alzheimer’s Disease (in father)	0.6	0.6	2.0	0.0	0.1	1.4	-1.0	-0.2
Prostate Cancer	0.6	0.8	2.6	0.2	-1.6	0.8	-0.9	-0.4
Bipolar Disorder (2011)	0.6	0.6	1.2	0.6	1.1	-0.8	-0.3	0.6
Cardiovascular Disease	0.6	1.8	4.0	0.4	1.9	-2.0	0.8	0.9
Hypothyroidism (self reported)	0.6	1.3	4.3	0.9	-0.3	2.1	0.8	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	0.4	-0.1	0.9	0.9	1.2
Supplements: Zinc	0.6	0.6	1.4	-0.8	-1.2	-0.4	-0.6	-0.7
Trunk fat percentage	0.6	2.4	7.0	-2.6	-0.4	-1.1	-1.6	-1.0
Average weekly fortified wine intake	0.6	0.7	1.6	1.3	0.3	-0.2	1.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.9	-0.0	0.8	1.0	0.3	1.4
Alcohol usually taken with meals	0.6	0.9	2.6	1.4	0.1	-0.2	1.6	0.5
Neuroticism score	0.6	1.3	2.7	-1.4	-0.3	-1.6	-0.6	-1.2
Trunk fat-free mass	0.6	3.4	8.7	3.0	0.9	2.4	1.1	0.6
Falls in the last year	0.6	0.8	2.2	-1.0	1.5	-0.3	-0.8	0.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	-0.7	0.6	-0.9	0.2	-1.2
Trunk predicted mass	0.6	3.2	8.4	2.9	0.9	2.4	1.1	0.5
Length of working week for main job	0.6	0.7	2.4	0.5	-0.8	1.6	-0.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.9	1.4	0.5	1.3	1.0	0.3
Pulse wave peak to peak time	0.6	0.7	1.4	0.8	-0.3	1.2	-0.2	1.2
Number of full sisters	0.6	0.8	1.8	0.7	-0.4	0.3	1.1	1.4
Overall health rating	0.6	1.3	4.5	-1.4	0.0	-2.1	-0.3	-0.2
Family relationship satisfaction	0.6	0.7	2.7	-0.3	-1.7	-0.0	-0.7	0.1
Eye problems/disorders: Cataract	0.6	0.7	2.1	1.5	-0.4	1.0	-0.5	0.4
Commuting to job workplace: Cycle	0.6	0.7	2.5	-0.1	-1.6	0.2	-0.8	-0.6
Myopia	0.6	0.8	2.4	-0.8	0.4	-1.5	0.3	-0.9
Cholesterol lowering medication	0.6	1.0	2.8	0.0	1.3	0.4	0.5	1.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	-1.1	-0.8	-0.4	-0.9	-0.7
Crohns Disease (2017)	0.5	1.2	4.5	-1.0	0.6	-2.1	0.1	-0.2
Heel T-Score	0.5	4.1	7.2	1.8	1.9	0.7	2.4	2.7
Respiratory disease	0.5	1.1	3.8	-0.1	1.0	-2.0	0.5	-0.7
Lung FVC	0.5	2.7	6.7	2.2	0.3	2.6	-0.5	-1.1
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-1.4	0.4	-1.4	0.3	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	2.5	0.1	1.6	-0.4	-0.4	0.0
Body mass index (BMI)	0.5	2.2	6.9	-1.6	-0.4	-2.6	-0.9	-0.7
Had menopause	0.5	0.6	1.9	-0.8	0.2	-1.4	-0.1	-0.6
Pain all over the body in last month	0.5	0.5	1.8	-0.1	0.8	1.3	-0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.0	-1.4	-0.2	-0.9	-1.0	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	0.7	1.7	-0.0	0.1	-0.1
Body fat percentage	0.5	1.8	5.5	-2.3	-0.4	-1.3	-1.1	-0.6
Number of children fathered	0.5	0.6	0.9	0.8	0.9	0.9	0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.9	0.3	0.1	1.4	0.4	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.5	-0.1	0.7	-0.0	0.8	1.2
Medication for cholesterol	0.5	0.8	1.8	-1.0	-1.3	0.1	-0.6	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-0.8	0.5	0.1	-1.1	-1.0
Medication: Aspirin	0.5	0.7	1.6	-0.3	0.2	-0.3	1.2	1.3
Breast Cancer	0.4	1.1	1.7	1.3	1.3	0.9	0.5	1.0
Ovarian Cancer	0.4	0.6	2.5	-0.5	-0.1	-1.6	0.5	-0.1
Mean Putamen Volume	0.4	0.5	1.4	-0.2	1.0	-1.2	-0.0	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-1.0	-0.7	0.7	-0.8	-0.0
Supplements: Glucosamine	0.4	0.5	1.3	0.8	-1.1	0.6	-0.5	-0.5
Past tobacco smoking	0.4	0.7	2.9	1.7	0.4	-0.3	0.3	-0.1
Financial difficulties in last 2 years	0.4	0.5	1.0	0.8	-0.2	0.4	1.0	0.9
Alcohol intake versus 10 years previously	0.4	0.6	2.3	0.4	-0.4	1.5	-0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	0.5	0.7	1.0	0.2	1.3
Happiness	0.4	0.5	1.5	-0.3	0.7	-1.2	-0.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	0.6	-0.8	0.9	0.2	0.8
Asthma	0.4	0.9	2.0	1.2	1.4	-0.3	0.9	-0.1
Prospective memory result	0.4	0.5	1.6	0.0	1.2	-1.1	0.1	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	-1.2	0.9	-0.2	-0.8	-0.5
Medication: Paracetamol	0.4	0.7	1.9	-0.9	1.4	-0.6	-0.6	-0.5
Comparative body size at age 10	0.4	1.0	2.1	1.4	-0.2	-0.2	1.4	1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.8	1.3	-0.7	0.5	0.5	0.8
Medication: Omeprazole	0.4	0.5	1.0	-1.0	-0.5	-0.4	-0.8	-0.5
Arm predicted mass (right)	0.4	1.8	5.6	2.4	0.8	1.6	0.7	0.1
Leg pain on walking	0.4	0.5	1.4	0.3	0.6	-1.2	-0.6	0.7
Medication: Aspirin	0.4	0.6	0.8	-0.8	-0.4	-0.9	0.9	0.7
Smoking status: Previous	0.4	0.6	1.2	-0.6	0.3	0.8	0.9	1.1
Diabetes diagnosed by doctor	0.4	0.7	2.8	0.7	0.0	-0.2	0.2	1.7
Asthma (self-reported)	0.4	0.7	1.6	0.9	1.3	-0.6	0.8	-0.4
Number of self-reported non-cancer illnesses	0.4	0.7	1.8	-0.6	1.3	-0.4	-1.1	-0.3
High cholesterol (Self-reported)	0.4	0.8	1.9	0.7	0.7	0.2	1.0	1.4
Irritability	0.4	0.7	1.7	-1.3	-0.7	-1.0	-0.8	-0.0
Age started oral contraceptive pill	0.4	0.6	1.3	0.8	-0.0	0.0	0.8	1.2
Diastolic blood pressure, automated reading	0.4	1.3	1.9	1.4	1.1	-0.7	1.3	1.2
Arm predicted mass (left)	0.4	1.8	4.8	2.2	0.5	1.9	0.6	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.7	0.4	-0.8	0.8	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	2.8	-0.8	0.3	-1.7	0.1	0.1
Primary Biliary Cirrhosis	0.3	0.4	1.2	0.7	0.0	0.6	0.1	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.8	0.2	-0.2	-1.4	-0.0	0.9
Hair Pigment	0.3	8.5	13.0	-3.0	0.9	-3.0	-3.3	-3.6
Medication for hormone replacement therapy	0.3	0.4	1.1	0.3	1.0	0.1	-0.3	-0.7
Fed-up feelings	0.3	0.6	2.3	0.1	1.5	0.3	0.2	0.5
Taking other prescription medications	0.3	0.5	1.0	0.9	0.9	1.0	-0.0	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.7	-0.5	0.1	-0.2	-1.3	-0.4
Medication: Levothyroxine sodium	0.3	0.5	0.9	0.7	0.6	0.7	0.9	0.6
High blood pressure (mother)	0.3	0.4	1.0	-1.0	-1.0	-0.2	-0.2	-0.4
Heart attack	0.3	0.3	1.0	-1.0	0.4	-0.7	-0.0	-0.1
Diabetes (self-reported)	0.3	0.4	1.3	0.1	-0.4	-0.8	0.2	1.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.8	0.3	-0.9	0.5	-0.7	-0.3
Medication: Ramipril	0.3	0.4	1.2	-1.1	-0.2	-0.7	0.0	-0.1
Medication: Simvastatin	0.3	0.5	1.4	-0.7	0.4	-1.2	-0.4	0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.6	0.3	1.3	-0.4	-0.2	0.6
Lung cancer (father)	0.3	0.4	1.0	-1.0	-0.5	-0.1	-0.1	-0.8
Medication: Amlodipine	0.3	0.5	1.3	-0.3	1.2	-0.3	-0.4	-0.8
Arm fat-free mass (right)	0.3	1.8	5.4	2.3	0.6	1.6	0.6	0.0
Exposure to tobacco smoke outside home	0.3	0.3	1.2	-0.0	-1.1	-0.5	-0.6	0.0
Medication: Allopurinol	0.3	0.4	2.0	0.1	-0.1	0.2	-1.4	0.4
Chest pain or discomfort	0.3	0.4	0.7	-0.8	-0.6	0.8	0.2	-0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	-0.6	-0.7	0.9	-0.2	-0.3
Whole body fat-free mass	0.3	1.7	5.1	2.2	0.6	1.7	0.6	0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.5	-0.2	-0.2	1.2	-1.0	0.3
Whole body water mass	0.3	1.5	4.3	2.1	0.5	1.6	0.5	-0.0
Arm fat mass (left)	0.3	1.4	2.9	-1.7	-0.2	-1.6	-0.9	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.5	0.9	0.5	-0.4	-0.4
Medication: Blood pressure	0.3	0.6	1.7	-0.2	0.8	-1.3	0.6	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	0.8	0.4	0.2	1.0	0.2
Medication: Lisinopril	0.3	0.4	0.6	0.7	0.1	-0.7	0.7	0.6
Arm fat-free mass (left)	0.3	1.6	4.6	2.1	0.5	1.6	0.7	0.2
Ever depressed for a whole week	0.3	0.4	1.3	-0.0	0.2	-0.3	-1.1	-0.7
Unable to work because of sickness or disability	0.3	0.4	1.1	1.1	-0.1	0.9	-0.1	0.5
Supplements: Calcium	0.3	0.3	1.4	-0.2	0.3	-0.3	-0.3	-1.2
Pack years of smoking	0.3	0.4	0.9	-0.6	-0.9	-0.5	-0.7	0.1
Impedance of whole body	0.3	1.4	5.5	-0.7	0.3	2.3	0.0	0.8
Bipolar Disorder (2018)	0.2	0.3	1.3	0.2	-0.1	-1.1	-0.0	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	-0.2	0.5	-1.1	0.3	-0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.5	0.7	-0.2	0.0	0.4
Chronotype (morning person)	0.2	0.5	1.3	-0.4	-0.3	-1.1	0.8	-0.3
Relative age of first facial hair	0.2	0.5	1.5	1.2	0.2	0.3	0.7	0.4
Medication: Metformin	0.2	0.3	0.8	0.4	-0.6	-0.3	-0.3	0.9
Pack years adult smoking proportion	0.2	0.3	0.7	-0.5	-0.8	-0.4	-0.6	0.1
Relative age voice broke	0.2	0.3	0.6	0.8	-0.4	0.7	0.1	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.6	0.2	-0.2	-0.0	-0.0	-1.3
Trunk fat mass	0.2	0.9	2.4	-1.6	-0.1	-0.4	-1.2	-0.7
Impedance of arm (right)	0.2	1.1	4.2	-1.0	0.1	2.1	-0.1	0.7
Impedance of arm (left)	0.2	0.9	3.0	-1.7	0.0	1.0	-0.6	-0.0
Arm fat mass (right)	0.2	1.0	2.3	-1.5	-0.1	-1.4	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.6	0.7	-0.1	1.3	0.4	0.4
Leg fat percentage (right)	0.2	0.6	1.6	-1.3	0.2	-1.0	-0.0	0.5
Number of full brothers	0.2	0.2	0.8	-0.4	-0.4	0.1	0.0	-0.9
Knee pain experienced in last month	0.2	0.3	0.8	-0.1	-0.9	0.0	0.7	0.5
Average weekly red wine intake	0.2	0.2	0.5	-0.1	-0.6	0.7	-0.5	0.2
Ever had bowel cancer screening	0.2	0.3	1.0	0.1	0.2	-1.0	0.1	-0.4
Friendships satisfaction	0.2	0.2	0.4	0.4	0.7	-0.3	0.1	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.1	0.3	0.4	-0.5	-0.9
Medication: Gliclazide	0.2	0.2	0.8	-0.1	-0.2	0.3	-0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	0.7	-0.5	1.0	-0.5	-0.4
Ever taken oral contraceptive pill	0.2	0.3	0.9	-0.9	0.5	-0.3	0.1	0.3
Mother’s age at death	0.2	0.3	0.6	-0.6	-0.8	0.0	-0.5	0.1
Financial situation satisfaction	0.2	0.2	0.6	-0.1	0.4	-0.3	-0.8	0.2
Medication: Bendroflumethiazide	0.2	0.3	1.1	-0.3	-0.0	-1.1	-0.3	-0.4
Medication: Atorvastatin	0.2	0.2	0.7	0.1	0.1	0.2	0.7	0.8
Basal metabolic rate	0.2	1.0	3.1	1.8	0.6	1.2	0.4	0.1
Leg fat percentage (left)	0.2	0.5	1.3	-1.1	0.2	-1.1	-0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.8	0.5	-0.5	0.1	-0.0
Ulcerative Colitis (UC)	0.1	0.2	0.9	0.1	0.2	-1.0	0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.0	0.4	-0.5	0.3	-0.7
Fasting Glucose	0.1	0.1	0.5	-0.2	0.3	-0.7	0.1	0.1
LDL Cholesterol	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4	0.0
Neuroticism (2016)	0.1	0.2	0.4	0.5	0.6	-0.6	0.1	0.1
Ulcerative Colitis	0.1	0.2	0.3	0.5	-0.2	0.6	-0.5	0.4
Blood Red Count	0.1	1.3	2.4	1.0	1.2	0.8	1.6	1.0
Tanning	0.1	1.5	2.9	1.5	-1.0	1.7	0.9	0.6
Number of treatments/medications taken	0.1	0.3	0.6	-0.3	0.7	-0.1	-0.8	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.0	-0.2	-0.4	0.4	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.1	0.1	-0.1	-0.4	0.6
Leg fat-free mass (left)	0.1	0.3	0.9	0.9	0.2	0.5	-0.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.5	0.3	0.2	-0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.0	-0.4	-0.9	0.0	0.4
Medication: Atenolol	0.1	0.1	0.3	-0.3	0.4	0.2	0.2	0.5
Leg predicted mass (left)	0.1	0.3	0.9	1.0	0.2	0.5	-0.1	-0.4
Waist circumference	0.1	0.2	0.7	-0.0	0.5	-0.3	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.1	-0.5	-0.7	0.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.4	-0.1	-0.5	0.3	0.5
Qualifications: None of the above	0.1	0.2	1.0	-0.4	0.1	1.0	0.2	0.0
Allergy	0.1	0.3	0.6	-0.7	-0.1	0.2	-0.6	0.8
Hip circumference	0.1	0.6	1.5	-0.7	0.8	-1.2	-0.3	-0.3
Time employed in main current job	0.1	0.2	0.5	-0.3	0.3	0.1	0.7	-0.2
Pulse rate	0.1	0.2	0.3	0.4	0.3	-0.3	-0.6	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.8	-0.4	-0.9	0.1	-0.5	-0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.5	0.3	-0.5	-0.3	0.2
Headache pain in last month	0.1	0.1	0.2	-0.4	0.4	-0.5	0.3	-0.4
High blood pressure (siblings)	0.1	0.1	0.3	-0.5	0.1	-0.4	-0.2	-0.3
Health satisfaction	0.1	0.1	0.3	0.3	-0.0	-0.2	0.5	0.6
Medication: Blood pressure	0.1	0.3	0.7	-0.6	0.2	-0.9	-0.3	0.2
Whole body fat mass	0.1	0.5	1.5	-1.2	-0.2	-0.5	-0.9	-0.4
Alcohol intake frequency.	0.1	0.3	0.8	-0.2	-0.5	-0.6	-0.5	-0.9
Suffer from ‘nerves’	0.1	0.1	0.3	0.4	0.5	0.2	0.5	-0.0
Leg fat-free mass (right)	0.1	0.4	1.5	1.2	0.4	0.4	-0.2	-0.5
Leg predicted mass (right)	0.1	0.4	1.6	1.3	0.4	0.4	-0.2	-0.5
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.5	0.3	0.3	0.1	0.6
Pain experienced in last month	0.1	0.1	0.4	0.6	0.2	-0.3	-0.3	0.2
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.3	-0.3	0.1	-0.0	0.5
Blood Platelet Count	0.0	0.3	0.5	-0.4	-0.7	-0.4	-0.4	-0.5
Nervous feelings	0.0	0.1	0.2	0.4	-0.3	-0.0	0.3	0.2
Fluid intelligence score	0.0	0.1	0.2	-0.1	0.1	0.1	0.0	-0.5
Weight	0.0	0.0	0.1	0.2	0.4	-0.1	-0.0	-0.2
Leg fat mass (right)	0.0	0.1	0.2	-0.4	0.1	-0.2	-0.1	0.4
Leg fat mass (left)	0.0	0.1	0.1	-0.3	0.2	-0.1	-0.2	0.3

Hub : Genes

AK3P3

Models

Trait associations