Hub : Genes

RABGEF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0300	2.5e-12	0.124	0.105	0.109	0.107	0.112	7.0e-15	9.2e-13	3.7e-13	6e-13	1.8e-13
2	GTEx	Thyroid	0.0380	0.0220	1.3e-03	0.043	NA	0.029	NA	0.029	2.9e-04	NA	2.5e-03	NA	2.6e-03
3	TCGA	Bladder Urothelial Carcinoma	0.0600	0.0390	3.8e-03	0.002	0.013	0.017	NA	0.005	2.1e-01	2.4e-02	1.3e-02	NA	1.1e-01
4	TCGA	Brain Lower Grade Glioma	0.0676	0.0383	1.6e-04	0.010	0.027	0.029	NA	0.024	2.1e-02	4.2e-04	2.7e-04	NA	9.1e-04
5	TCGA	Prostate Adenocarcinoma	0.0727	0.0391	8.9e-04	0.040	0.018	0.023	NA	0.027	4.7e-05	5.2e-03	1.7e-03	NA	7.4e-04
6	TCGA	Testicular Germ Cell Tumors	0.1960	0.0820	5.3e-06	0.190	0.177	0.139	NA	0.178	2.8e-07	7.5e-07	1.3e-05	NA	6.9e-07
7	TCGA	Thyroid Carcinoma	0.2470	0.0780	0.0e+00	0.330	0.346	0.348	NA	0.350	6.5e-33	7.5e-35	4.4e-35	NA	2.6e-35

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.5	2.3	6.2	1.6	-1.7	-0.8	-0.5	-0.8	-2.5	-1.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.0	0.5	-0.8	-0.9	-0.7	-1.3	-1.4	-0.9
Depressed Affect (Nagel 2018)	0.1	0.3	1.2	0.1	0.2	-0.4	-0.5	-1.1	-0.4	-0.1
Depression (Nagel 2018)	2.7	4.1	12.9	-0.8	0.5	-2.3	-2.9	-3.6	-1.0	0.3
Intelligence (Savage-Jansen 2018)	1.1	3.2	6.8	2.6	-2.2	-0.7	1.4	0.2	-1.9	-2.2
Neuroticism (Nagel 2018)	0.4	0.9	3.1	0.4	-0.0	-1.2	-1.0	-1.8	-0.9	-0.3
Schizophrenia (2018)	0.2	0.3	1.1	-0.7	0.4	-0.5	-0.5	-1.0	0.2	0.2
Schizophrenia vs Biploar Disorder	2.1	2.7	5.5	-1.7	1.8	1.5	0.5	1.4	2.3	1.8
Worry (Nagel 2018)	0.1	0.1	0.4	-0.2	0.4	-0.2	-0.4	-0.7	0.1	0.3
Alzheimer’s Disease (in mother)	1.3	1.5	4.9	-1.2	0.9	-0.6	-2.2	-1.4	-0.4	1.0
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.2	-0.7	-0.9	-0.5	-0.7	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	3.9	-0.7	0.2	-1.3	-2.0	-1.5	-0.5	0.3
Crohns Disease (2017)	0.4	0.9	1.5	-1.2	1.2	0.5	-1.2	-0.3	0.8	1.2
Irritable Bowel Disease (IBD)	0.3	0.8	1.4	-0.9	1.1	0.9	-0.9	-0.4	0.6	1.2
Ulcerative Colitis (UC)	0.4	0.7	1.4	-0.8	1.0	1.1	-0.5	-0.0	0.6	1.2
Major Depression (MDD)	1.9	2.4	5.4	0.3	-0.6	-2.2	-1.4	-2.3	-1.8	-0.7
Reaction Time	0.5	0.9	2.8	0.7	-0.8	-1.1	-0.2	-1.7	-0.7	-1.0
Verbal and Numeric Reasoning (VNR)	3.8	9.0	16.4	4.1	-3.7	-1.7	2.2	-0.3	-3.1	-3.9
Breast Cancer	0.1	0.3	0.8	-0.3	0.6	0.8	0.3	0.2	0.9	0.4
Ovarian Cancer	0.5	0.6	1.8	-0.0	0.1	-1.3	-1.1	-1.1	-0.4	-0.1
Prostate Cancer	0.4	0.6	1.5	0.8	-0.2	-1.1	-0.2	-1.2	-0.7	-0.5
Age at First Birth	0.2	0.3	0.9	0.6	-0.6	0.5	0.2	0.5	-0.9	-0.3
Bipolar Disorder (2011)	2.5	2.4	5.4	1.7	-1.9	-1.0	0.1	-0.7	-2.3	-1.8
Body Mass Index (BMI) (2010)	1.0	1.4	3.5	-0.1	-0.1	-1.9	-1.5	-1.9	-0.7	-0.2
Coronary Artery Disease (CAD)	0.3	0.4	1.5	-0.4	-0.3	0.3	-1.2	-0.2	-0.7	0.3
Crohns Disease (2012)	0.1	0.1	0.4	0.1	-0.2	0.3	-0.6	-0.2	-0.6	-0.0
Mean Putamen Volume	0.6	0.7	1.3	-1.0	0.8	0.5	-0.8	0.8	0.4	1.1
Fasting Glucose	0.4	0.5	2.7	-0.1	-0.1	-0.0	-1.6	-0.7	-0.3	0.1
HbA1C	1.7	1.8	7.2	-1.0	0.0	-1.1	-2.7	-1.9	0.1	0.2
HDL Cholesterol	0.7	1.2	3.2	-0.2	0.6	1.8	1.1	1.5	1.0	0.7
LDL Cholesterol	1.5	2.3	4.1	-1.9	1.7	1.2	-0.9	1.2	1.4	2.0
Lupus	1.1	1.6	4.2	1.5	-1.4	-0.7	0.5	-0.3	-2.1	-1.4
Neuroticism (2016)	0.3	0.5	1.7	-0.5	-0.1	-1.3	0.3	-1.2	0.1	0.0
Primary Biliary Cirrhosis	0.7	1.0	3.6	-0.1	0.4	-1.2	-1.3	-1.9	-0.5	-0.1
Rheumatoid Arthritis	0.6	0.9	2.3	-0.4	0.6	1.0	1.1	1.0	1.5	0.4
Schizophrenia (2014)	0.0	0.0	0.2	-0.1	-0.1	-0.2	-0.0	-0.4	-0.0	-0.2
Triglycerides	2.0	3.3	5.2	1.2	-1.6	-2.3	-1.2	-2.2	-2.2	-1.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	1.1	-1.0	-0.2	0.9	0.1	-0.6	-1.0
Ulcerative Colitis	0.2	0.3	0.8	-0.4	0.1	0.1	-0.9	-0.6	-0.5	0.3
Blood Eosinophil Count	0.6	4.5	11.2	-0.7	0.7	-3.2	-2.9	-3.3	-0.4	0.5
Blood Platelet Count	0.4	4.3	10.7	-2.1	2.9	0.9	-0.2	0.2	3.3	2.4
Blood Red Count	0.1	1.3	2.4	1.6	-1.3	-0.0	1.0	1.2	-0.8	-1.3
Blood White Count	4.3	31.9	54.5	-6.5	6.3	-2.1	-7.4	-6.2	3.4	5.7
Heel T-Score	0.4	3.4	6.2	2.5	-1.9	-1.4	1.4	-1.4	-1.6	-2.3
BMI	0.7	4.2	10.5	-1.5	1.5	-2.3	-3.2	-2.8	-0.6	1.2
Height	1.5	28.5	45.6	-6.5	6.2	4.3	-2.8	4.2	5.4	6.8
Waist Hip Ratio (WHR)	0.2	0.7	2.9	-0.4	0.8	0.4	1.1	-0.0	1.7	0.3
Systolic Blood Pressure	0.3	1.7	4.0	-1.0	0.9	1.5	0.3	2.0	1.5	1.3
Smoking Status	0.6	1.5	4.8	-0.0	0.4	-2.2	-1.1	-2.1	-0.2	-0.0
Allergy or Eczema	0.1	0.3	0.9	-0.5	0.5	0.9	0.0	-0.2	0.5	0.4
Cardiovascular Disease	0.0	0.1	0.1	-0.3	0.3	-0.1	-0.3	-0.2	0.3	0.2
Hypothyroidism (self reported)	0.6	1.4	4.1	-0.4	0.5	-1.9	-1.2	-2.0	0.3	0.2
Respiratory disease	0.4	0.9	2.5	-0.2	0.3	-1.2	-1.5	-1.6	-0.5	0.0
Type 2 Diabetes (T2D) (2018)	3.0	5.7	9.3	-3.1	3.0	0.3	-3.0	-1.3	1.5	2.9
Lung FEV1/FVC ratio	1.0	5.1	13.0	-2.6	2.1	-1.7	-3.6	-2.0	0.5	2.1
Lung FVC	1.7	8.9	16.4	3.8	-4.0	-0.2	2.3	0.7	-3.5	-3.7
Neuroticism	0.2	0.4	1.1	0.4	0.0	-0.8	-0.5	-1.1	-0.8	-0.4
Chronotype (morning person)	0.5	1.2	3.2	-0.8	0.1	-1.6	-1.4	-1.8	0.1	0.2
Hair Pigment	0.1	1.7	3.0	1.5	-1.4	-1.2	-0.0	-1.1	-1.7	-1.4
Tanning	0.2	2.3	5.9	1.8	-1.8	-0.9	0.3	-0.5	-2.4	-1.5
Hand grip strength (left)	0.2	0.5	2.2	-0.5	0.2	0.7	-0.5	1.5	-0.1	0.7
Number of treatments/medications taken	0.6	1.1	2.4	-1.2	1.1	-0.3	-1.6	-1.2	0.2	1.1
Average weekly spirits intake	1.3	1.6	2.9	-1.7	1.7	0.4	-0.8	-0.1	1.5	1.5
Sensitivity / hurt feelings	0.6	1.0	2.3	-0.7	0.6	-1.3	-1.5	-1.5	-0.1	0.6
Frequency of depressed mood in last 2 weeks	1.9	2.7	8.5	-0.4	0.1	-2.0	-2.3	-2.9	-1.1	0.1
Hearing difficulty/problems: Yes	3.4	5.3	8.7	1.9	-2.1	-3.0	-0.9	-2.6	-2.9	-2.1
Relative age of first facial hair	0.3	0.6	1.7	0.7	-1.1	0.6	0.2	-0.0	-1.3	-0.8
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	5.7	2.4	-2.1	-1.8	0.8	-1.2	-2.2	-2.3
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.9	0.8	-1.5	-2.2	-0.8	-1.8	-1.7	-1.3
Ever had hysterectomy (womb removed)	1.0	1.2	2.8	1.2	-1.5	-0.5	0.7	-0.4	-0.8	-1.7
Systolic blood pressure, automated reading	0.2	0.6	1.3	-0.7	0.7	0.9	-0.4	1.1	0.4	1.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	-1.3	1.3	0.0	-1.1	-0.6	0.8	1.1
Angina	1.2	1.6	3.8	0.5	-0.5	-1.7	-1.2	-2.0	-1.6	-0.6
Medication for hormone replacement therapy	0.6	0.7	2.3	0.2	-0.6	-0.8	-1.0	-0.6	-1.5	-0.4
Vitamin and mineral supplements	0.6	0.8	2.1	0.2	-0.4	-1.1	-1.0	-1.4	-0.7	-0.4
Supplements: Zinc	0.7	0.7	1.6	1.3	-0.8	-0.2	0.9	0.3	-0.6	-1.1
Medication: Co-codamol	2.4	2.8	4.4	1.9	-1.8	-1.8	0.3	-1.1	-2.1	-1.9
Medication: Metformin	1.9	2.7	5.0	-2.0	2.2	0.9	-1.3	0.0	1.7	2.1
Diabetes (father)	0.6	0.8	1.8	-0.7	0.8	1.4	0.2	1.1	0.7	0.9
Diabetes (mother)	0.1	0.1	0.2	0.5	-0.0	-0.1	0.4	0.2	0.1	-0.2
Severe depression (siblings)	0.1	0.2	0.8	0.4	-0.1	0.2	0.1	-0.2	-0.9	-0.2
Pack years adult smoking proportion	0.5	0.8	1.5	1.1	-1.1	-0.2	0.6	-0.2	-1.2	-1.1
Impedance of leg (right)	0.5	2.4	4.7	-2.2	1.8	0.9	-0.9	0.4	1.9	1.9
Leg fat-free mass (left)	0.9	4.6	8.6	-2.7	2.9	0.6	-2.4	0.6	1.4	2.9
Trunk fat percentage	1.9	7.5	19.4	-3.0	2.6	-1.9	-4.4	-2.7	0.4	2.5
Hand grip strength (right)	0.1	0.2	0.5	-0.2	-0.3	-0.1	-0.6	0.7	-0.6	0.1
Townsend deprivation index at recruitment	1.0	1.4	5.1	-0.4	0.3	-1.6	-1.3	-2.3	-0.3	0.1
Current tobacco smoking	0.1	0.2	0.5	-0.1	0.7	-0.2	0.3	-0.1	0.6	0.5
Average weekly fortified wine intake	1.5	1.8	2.8	1.7	-1.6	-1.3	0.3	-0.7	-1.6	-1.5
Maternal smoking around birth	2.4	3.5	8.6	-0.8	0.5	-2.7	-2.6	-2.9	-0.6	0.4
Fed-up feelings	0.1	0.1	0.5	0.2	0.3	-0.1	0.2	-0.7	0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.2	14.1	-0.9	0.7	-2.6	-2.6	-3.8	-0.2	0.4
Relative age voice broke	0.4	0.6	1.3	0.7	-1.1	-0.5	0.2	-0.5	-0.8	-1.0
Taking other prescription medications	0.3	0.5	3.1	-0.2	0.4	-0.2	-0.6	-1.8	-0.1	0.0
Age when periods started (menarche)	0.3	0.8	2.2	0.1	-0.0	1.3	1.3	1.5	0.4	0.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.7	0.2	-1.0	-1.8	-1.3	-1.9	-1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	0.7	-0.8	0.2	0.8	0.5	-0.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.2	0.2	0.4	-0.1	0.2	0.2	0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.4	0.3	0.5	0.4	0.8	0.6	0.4
Serious illness, injury or assault to yourself	0.5	0.7	1.5	0.9	-0.4	-1.0	-0.3	-0.8	-1.2	-0.7
High blood pressure	0.1	0.3	0.6	-0.5	0.5	0.8	-0.6	0.3	0.1	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.8	0.8	1.0	-0.0	0.1	1.0	0.7
Multivitamins +/- minerals	0.4	0.5	1.2	0.6	-0.6	0.6	1.1	0.8	-0.0	-0.6
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.2	0.7	0.5	0.5	0.7	0.5	0.4
Supplements: Glucosamine	0.9	1.1	3.8	-0.6	0.5	1.5	0.4	2.0	0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.0	0.6	0.2	0.1	-0.1	0.3	0.3
Medication: Atenolol	0.1	0.1	0.2	-0.4	0.2	0.2	-0.4	-0.2	0.1	0.2
Medication: Levothyroxine sodium	0.2	0.3	1.2	-0.3	0.5	0.0	0.6	0.6	1.1	0.2
Sitting height	0.4	2.9	5.8	-2.1	2.1	0.5	-2.0	0.9	0.8	2.4
Chronic bronchitis/emphysema (father)	1.3	1.5	2.8	1.7	-1.6	-0.3	1.2	-0.2	-1.1	-1.6
High blood pressure (mother)	1.4	1.9	5.6	-0.1	0.8	2.1	1.2	2.4	0.6	0.8
Body mass index (BMI)	0.2	1.0	2.9	-0.6	0.8	-1.1	-1.7	-1.2	-0.5	0.7
Impedance of leg (left)	0.4	2.1	4.8	-1.8	1.7	0.8	-0.2	0.4	2.2	1.6
Leg predicted mass (left)	0.9	4.8	8.9	-2.8	2.9	0.6	-2.4	0.6	1.4	3.0
Trunk fat mass	1.7	7.5	15.7	-3.4	3.2	-0.9	-4.0	-1.6	1.2	3.1
Waist circumference	0.9	3.2	6.7	-2.2	2.6	0.1	-1.7	-0.4	1.6	2.3
Number of incorrect matches in round	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.3	0.0	-0.1	0.2
Past tobacco smoking	1.1	1.9	5.1	-0.8	0.6	2.1	0.8	2.3	1.1	1.0
Alcohol usually taken with meals	2.3	3.8	5.5	2.3	-2.3	0.8	2.0	1.7	-2.0	-2.0
Nervous feelings	0.1	0.3	0.6	0.5	-0.3	-0.7	-0.2	-0.8	-0.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	3.2	4.9	14.0	0.4	-1.0	-3.2	-2.2	-3.7	-1.7	-1.2
Hearing difficulty/problems with background noise	3.6	5.8	15.3	1.0	-1.0	-3.5	-2.1	-3.9	-2.3	-1.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.2	-0.0	0.1	-0.3	-0.1	-0.2	-0.4	0.1
Had menopause	0.4	0.5	2.1	0.3	-0.3	-0.7	0.1	-1.4	0.1	-0.7
Had other major operations	0.3	0.4	1.1	0.7	-0.3	-0.5	-0.4	-0.7	-1.1	-0.5
Forced vital capacity (FVC)	0.3	1.3	2.4	-1.3	1.2	1.0	-1.2	1.2	0.2	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.9	-0.7	-0.1	0.6	-0.1	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	0.0	0.0	-0.1	-0.2	-0.3	-0.2	0.0
Qualifications: None of the above	1.4	3.0	6.6	-2.0	2.5	0.2	-0.6	-0.8	2.6	1.8
Financial difficulties in last 2 years	3.2	4.4	11.2	0.3	-0.3	-3.3	-2.3	-3.3	-1.7	-0.4
Mouth/teeth dental problems	1.7	2.6	4.5	-2.1	1.6	1.8	-0.5	1.0	1.9	1.8
Heart attack	0.9	1.1	3.3	0.3	-0.6	-1.6	-0.7	-1.8	-1.0	-0.6
Allergy	0.1	0.1	0.4	-0.1	-0.2	-0.6	-0.5	-0.2	-0.4	0.0
Pain all over the body in last month	1.1	1.1	2.1	-0.6	1.0	1.5	0.7	1.4	1.1	1.0
Diabetes (self-reported)	1.4	2.2	4.9	-1.5	1.3	-1.1	-2.2	-1.9	0.4	1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.6	-0.6	0.6	0.7	0.5	-0.4	-0.6
Medication: Ramipril	2.4	3.1	6.7	-2.2	1.9	-0.2	-2.6	-1.7	0.5	1.8
Medication: Simvastatin	2.5	3.7	6.7	-2.6	2.3	1.4	-1.8	0.1	1.7	2.5
Fluid intelligence score	1.9	3.9	7.2	2.7	-2.5	-0.7	1.3	-0.1	-2.5	-2.4
Illnesses of siblings	0.6	0.8	2.8	-0.3	0.1	-1.4	-0.8	-1.7	-0.1	-0.2
Neuroticism score	0.3	0.7	1.3	0.3	-0.3	-1.0	-1.0	-1.1	-1.1	-0.3
Weight	1.2	5.7	10.2	-3.0	3.2	0.3	-2.7	0.0	1.6	3.2
Impedance of arm (right)	1.2	5.4	16.9	-2.6	1.3	-1.7	-4.1	-2.7	-0.1	1.7
Arm fat percentage (right)	1.2	4.6	13.5	-1.9	1.6	-1.9	-3.7	-2.5	-0.4	1.6
Trunk fat-free mass	1.2	6.6	10.1	-2.2	3.0	2.8	0.1	3.2	2.5	2.9
Hip circumference	0.9	4.0	7.3	-2.5	2.6	0.0	-2.7	-0.4	1.0	2.6
Time employed in main current job	2.0	2.3	5.1	-0.5	1.2	1.9	1.9	1.4	2.3	0.6
Alcohol intake versus 10 years previously	1.2	1.8	2.6	1.1	-1.5	-1.5	-0.3	-1.4	-1.6	-1.6
Father’s age at death	0.2	0.3	1.3	-0.1	0.4	0.2	0.7	0.3	1.2	0.1
Worrier / anxious feelings	0.8	1.6	4.7	-0.5	0.3	-1.1	-2.2	-1.9	-1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	8.5	-0.7	0.9	-2.3	-2.2	-2.9	-0.2	0.6
Falls in the last year	0.7	0.9	3.1	0.2	0.1	-1.3	-1.1	-1.8	-0.8	-0.2
Hair/balding pattern: Pattern 3	2.9	4.3	5.9	-2.2	2.0	2.4	-0.5	2.1	2.2	2.4
Number of live births	1.6	2.3	3.9	-1.7	2.0	-0.3	-1.2	-1.2	1.9	1.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.4	-1.7	1.4	0.9	-1.7	0.9	0.1	1.8
Pulse rate	2.0	3.4	6.1	-2.1	2.2	1.6	-0.2	1.1	2.5	2.2
Happiness	2.9	3.5	7.1	2.7	-2.3	-0.7	2.0	-0.2	-1.3	-2.5
Noisy workplace	0.3	0.4	1.3	0.1	0.2	-1.0	0.1	-1.1	0.3	-0.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.4	1.7	-1.5	1.6	2.1	2.0	-1.0	-1.3
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.2	6.3	2.5	-2.3	-2.0	0.8	-1.7	-2.1	-2.5
Mouth/teeth dental problems: Dentures	3.9	6.6	12.2	3.5	-3.0	-1.7	2.0	-0.6	-2.5	-3.4
Asthma	0.1	0.2	0.6	0.3	-0.1	-0.3	-0.3	-0.8	-0.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.6	0.5	-0.6	-1.9	-1.4	-1.8	-1.8	-0.5
Medication: Cholesterol lowering	0.1	0.1	0.6	0.1	0.2	-0.3	-0.0	-0.8	-0.2	0.0
Depression (self-reported)	0.7	0.9	1.4	1.2	-0.9	-0.9	0.4	-1.0	-0.7	-1.1
Medication: Lansoprazole	1.1	1.2	3.1	-1.0	1.2	1.0	0.5	0.6	1.8	1.0
Prospective memory result	1.1	1.3	2.4	-1.0	1.0	-1.4	-0.8	-1.6	1.3	0.7
Lung cancer (father)	0.1	0.1	0.3	0.1	-0.2	-0.3	-0.1	0.5	-0.2	-0.0
Illnesses of mother	0.3	0.4	1.1	-1.1	0.6	0.2	-0.7	-0.2	0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.4	-0.7	0.3	-0.2	-1.2	0.0	-0.4	0.5
Pulse wave Arterial Stiffness index	0.1	0.2	0.5	0.3	-0.4	0.2	0.0	0.7	-0.6	-0.1
Impedance of arm (left)	1.0	4.5	13.8	-2.3	1.0	-1.7	-3.7	-2.7	-0.1	1.4
Arm fat mass (right)	1.0	4.1	10.8	-2.2	2.2	-1.1	-3.3	-1.5	0.3	2.2
Trunk predicted mass	1.2	6.7	10.8	-2.1	2.9	2.9	0.2	3.3	2.5	2.9
Standing height	1.7	16.9	28.0	-5.0	5.0	3.0	-2.3	2.8	4.1	5.3
Length of working week for main job	1.7	1.9	4.2	1.7	-1.9	-0.6	0.2	-0.0	-2.0	-1.5
Exposure to tobacco smoke at home	0.7	0.8	1.5	-1.2	0.6	-0.2	-1.2	-1.2	0.4	0.7
Breastfed as a baby	2.5	3.1	6.2	2.2	-2.5	-0.9	1.4	-0.4	-1.4	-2.5
Tense / ‘highly strung’	0.1	0.2	0.8	-0.3	0.3	-0.2	-0.9	-0.6	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.3	0.3	-0.0	-0.9	-0.4	-1.5	-0.4	-0.2
Hair/balding pattern: Pattern 4	3.1	7.5	12.0	3.1	-2.9	-3.1	1.2	-2.6	-2.0	-3.5
Birth weight of first child	0.8	1.4	3.2	-1.7	1.1	0.7	-1.8	0.2	0.1	1.5
Peak expiratory flow (PEF)	0.1	0.2	0.7	0.2	-0.5	0.3	-0.1	0.8	-0.8	-0.1
Pulse wave reflection index	0.7	0.9	2.7	0.6	-0.7	-1.2	-0.9	-0.3	-1.6	-0.4
Ever highly irritable/argumentative for 2 days	1.7	2.1	6.9	-1.2	1.0	-1.2	-2.6	-1.6	-0.4	1.1
Loud music exposure frequency	0.3	0.4	0.6	0.6	-0.5	-0.8	0.2	-0.8	-0.2	-0.7
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	5.3	2.1	-2.2	1.2	2.3	1.9	-1.4	-1.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.1	-0.3	0.2	-0.7	-1.8	-0.9	-1.1	0.5
Blood clot in the leg (DVT)	1.4	1.8	4.9	1.5	-1.2	0.4	2.2	1.6	0.2	-1.3
Medication: Paracetamol	0.4	0.6	1.4	-0.7	0.9	-0.1	-1.2	-0.9	-0.2	0.9
Headache pain in last month	0.5	0.8	2.4	0.7	-0.8	-1.0	-0.7	-0.4	-1.5	-0.6
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.0	-0.2	0.2	0.0	0.4	0.1	-0.1
Glaucoma (self-reported)	0.0	0.0	0.2	-0.1	0.1	0.2	-0.1	-0.0	0.5	0.2
Gout (self-reported)	0.1	0.1	0.2	-0.2	0.2	0.3	-0.4	-0.5	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.4	-0.2	0.4	-1.2	-0.5	-1.1	0.3	0.1
Medication: Amlodipine	0.3	0.4	0.5	-0.0	0.7	0.7	0.7	0.7	0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.4	0.5	0.7	0.0	0.4	0.5	0.5
Birth weight	1.2	2.7	5.5	-2.2	1.7	0.7	-2.3	0.2	0.4	2.2
Chronic bronchitis/emphysema (mother)	2.1	2.5	4.1	-2.0	1.9	-0.2	-2.0	-1.0	1.2	1.8
High blood pressure (siblings)	0.8	1.2	3.5	-0.0	0.4	1.6	1.1	1.9	0.9	0.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.8	-0.0	-0.3	0.1	-0.6	0.4	-0.9	-0.1
Body fat percentage	1.4	5.6	13.1	-2.7	2.4	-1.5	-3.6	-2.2	0.7	2.3
Leg fat percentage (right)	0.9	3.1	6.3	-2.0	2.0	-1.0	-2.5	-1.6	0.7	1.8
Arm fat-free mass (right)	1.1	5.6	8.9	-2.1	3.0	2.3	0.0	2.5	2.6	2.8
Exposure to tobacco smoke outside home	0.6	0.8	1.8	-1.1	1.1	0.7	-0.1	-0.1	1.4	0.9
Comparative body size at age 10	0.9	2.5	4.4	-0.6	0.7	2.0	1.9	2.1	2.1	0.6
Number of full brothers	1.2	1.5	2.5	1.6	-1.5	-0.3	1.2	0.5	-1.2	-1.5
Worry too long after embarrassment	0.3	0.5	1.1	0.1	-0.1	-0.9	-1.1	-0.7	-0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.4	0.5	-0.2	-1.5	-1.5	-2.1	-1.4	-0.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.6	0.8	-0.2	-1.2	0.2	-1.3	-0.4	-0.8
Number of children fathered	1.1	1.3	2.7	1.2	-1.6	-0.1	0.3	0.1	-1.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.9	-0.2	0.2	-1.0	-0.9	-1.4	-0.1	-0.1
Age at first live birth	0.6	1.1	2.3	1.3	-1.4	-0.6	0.6	-0.6	-0.9	-1.5
Pulse wave peak to peak time	0.2	0.2	0.6	-0.4	0.5	-0.0	-0.0	-0.4	0.8	0.3
Health satisfaction	1.0	1.4	2.2	-1.4	1.5	-0.2	-1.4	-1.0	0.7	1.3
Shortness of breath walking on level ground	4.3	5.1	10.0	-2.3	2.1	-1.9	-3.2	-2.8	1.1	1.8
Qualifications: College or University degree	0.6	1.9	3.8	1.9	-1.8	-0.4	0.6	0.4	-1.9	-1.6
Eye problems/disorders: None of the above	1.2	1.3	4.3	1.2	-0.8	0.5	2.1	1.1	0.2	-1.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.5	1.4	-0.8	-0.3	1.6	0.6	-0.2	-1.1
Emphysema/chronic bronchitis	0.8	1.0	1.7	-1.1	1.3	-0.6	-0.7	-0.9	1.1	0.8
Medication for pain relief, constipation, heartburn	1.0	1.8	6.6	0.4	-0.2	1.4	1.8	2.6	0.9	-0.2
Neck or shoulder pain in last month	0.7	1.0	1.9	0.1	-0.1	-1.4	-1.2	-1.4	-1.2	-0.1
Medication: Blood pressure	0.2	0.4	1.1	-0.3	0.4	1.0	0.3	0.9	0.2	0.5
Angina (self-reported)	1.1	1.4	3.3	0.5	-0.6	-1.5	-1.0	-1.8	-1.6	-0.6
Migraine (self-reported)	3.3	4.0	8.5	2.4	-2.4	-1.4	0.4	-1.1	-2.9	-2.3
Medication: Ibuprofen	1.8	2.2	5.5	0.1	-0.2	-2.1	-1.8	-2.3	-1.5	-0.2
Medication: Allopurinol	0.3	0.4	0.7	-0.7	0.8	0.5	-0.8	-0.3	-0.1	0.8
Medication: Omeprazole	1.2	1.4	2.7	-1.7	1.1	1.4	-1.2	0.4	0.6	1.5
Medication: Seretide 50 evohaler	0.8	0.9	1.9	-0.7	1.2	0.8	0.7	0.8	1.4	0.8
Mean time to correctly identify matches	0.4	0.8	2.5	0.7	-0.7	-0.8	0.3	-1.6	-0.2	-1.0
Heart disease (mother)	0.7	0.9	1.8	1.3	-1.0	-0.1	1.0	0.2	-0.8	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.6	0.1	-0.1	0.1	0.8	0.6	0.4	-0.1
Whole body fat mass	1.5	6.1	12.2	-3.1	3.0	-0.6	-3.5	-1.2	1.2	3.0
Leg fat mass (right)	1.1	4.3	7.6	-2.6	2.6	-0.6	-2.7	-0.9	1.2	2.5
Arm predicted mass (right)	1.1	5.7	9.2	-2.2	3.0	2.2	-0.1	2.4	2.7	2.9
Pulse rate, automated reading	1.0	3.1	5.8	-2.2	2.4	0.9	-1.0	0.3	1.9	2.3
Alcohol intake frequency.	1.1	2.5	4.2	1.8	-1.9	-1.6	0.2	-0.9	-2.0	-1.8
Comparative height size at age 10	2.1	11.6	17.1	-3.9	3.9	3.1	-1.0	3.1	3.8	4.1
Number of full sisters	0.1	0.2	0.7	-0.1	0.1	-0.5	-0.2	-0.8	-0.2	0.1
Suffer from ‘nerves’	0.3	0.5	1.6	-0.9	0.8	0.2	-0.2	-0.5	1.3	0.7
Overall health rating	2.1	4.4	7.4	-2.5	2.7	-0.6	-2.5	-1.8	1.4	2.4
Chest pain or discomfort	0.1	0.2	0.3	0.6	0.1	-0.3	-0.1	-0.6	-0.5	-0.2
Had major operations	0.5	0.6	1.9	-0.7	1.0	-0.6	-0.2	-0.3	1.4	0.7
Age at last live birth	0.9	1.2	2.6	0.9	-0.9	-1.6	-0.3	-1.6	-0.8	-1.1
Family relationship satisfaction	1.6	2.0	2.8	1.4	-1.3	-1.6	-0.0	-1.6	-1.5	-1.7
Leg pain on walking	2.9	3.6	5.9	-2.2	2.4	1.9	-0.5	1.1	2.0	2.3
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	6.2	-1.5	1.5	2.5	0.3	2.3	1.7	1.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.8	0.5	0.6	-0.5	0.4	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	5.1	6.2	10.0	-3.1	2.7	2.3	-0.8	1.6	3.2	2.9
Medication: Aspirin	1.1	1.5	4.4	0.7	-0.9	-1.5	-0.5	-2.1	-1.1	-1.1
Supplements: Vitamin C	0.2	0.2	0.7	0.2	-0.4	0.6	-0.1	0.5	-0.8	-0.0
Knee pain experienced in last month	1.5	2.3	4.0	-1.5	1.6	2.0	-0.6	1.4	1.0	1.9
Hypertension (Self-reported)	0.3	0.8	1.8	-0.8	0.9	1.3	-0.4	0.8	0.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.7	0.7	1.0	-0.2	0.1	0.3	0.8
Illnesses of father: Heart disease	0.8	1.1	2.0	1.4	-1.4	0.3	1.0	0.1	-1.0	-1.4
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.7	0.8	0.3	-1.0	0.2	0.1	0.9
Smoking status: Previous	1.3	2.0	6.2	-0.2	0.1	-2.2	-1.7	-2.5	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.9	-1.7	1.6	0.1	-1.2	0.4	1.1	1.6
Whole body fat-free mass	0.9	5.4	9.0	-2.4	3.0	2.0	-0.8	2.2	2.1	3.0
Leg fat-free mass (right)	0.7	3.6	6.8	-2.3	2.6	0.6	-1.9	0.7	1.3	2.6
Arm fat percentage (left)	1.1	4.3	12.1	-1.9	1.6	-1.8	-3.5	-2.5	-0.2	1.6
Average weekly red wine intake	0.3	0.4	1.0	-0.4	0.4	-1.0	-1.0	-0.4	-0.0	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	0.2	0.3	1.1	1.2	1.1	0.7	0.0
Mood swings	0.4	0.8	2.6	-0.5	0.3	-0.4	-1.6	-1.2	-0.9	0.4
Loneliness, isolation	1.0	1.3	2.0	1.3	-1.1	-1.3	0.5	-1.0	-1.1	-1.4
Long-standing illness, disability or infirmity	1.5	2.2	6.0	1.0	-0.7	-2.1	-0.6	-2.4	-1.4	-1.2
Ever had bowel cancer screening	0.1	0.2	0.6	-0.2	0.3	-0.2	0.3	-0.4	0.8	-0.0
Diabetes diagnosed by doctor	2.5	4.1	6.4	-2.5	2.5	-0.2	-2.5	-1.5	1.4	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.5	0.6	-0.5	-0.5	-0.5	0.2	-1.2	-0.3
Friendships satisfaction	1.6	1.9	4.2	2.0	-1.4	-0.6	1.7	-0.4	-0.7	-1.9
Qualifications: nursing, teaching	3.7	5.8	9.4	2.8	-3.0	-2.0	0.7	-1.1	-3.1	-3.0
Commuting to job workplace: Walk	0.4	0.4	0.8	0.7	-0.6	-0.6	0.1	-0.6	-0.9	-0.7
Eye problems/disorders: Cataract	3.2	3.6	7.2	-2.5	2.3	1.0	-2.3	-0.1	1.0	2.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.1	0.0	-0.4	0.4	0.4	0.3	-0.0
Medication for cholesterol	0.3	0.4	0.6	0.7	-0.8	-0.6	0.4	-0.3	-0.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.2	-0.6	0.4	-0.5	0.0	-1.4	1.5	0.1
Back pain experienced in last month	1.1	1.6	4.3	-0.6	1.0	-1.1	-1.9	-2.1	-0.5	0.8
Mineral and other dietary supplements	1.4	1.9	4.1	1.1	-1.0	-2.0	-0.6	-1.9	-1.4	-1.2
Breast cancer (self-reported)	0.6	0.7	1.8	0.5	-0.2	1.1	1.4	1.3	0.2	-0.3
Asthma (self-reported)	0.2	0.4	0.8	0.5	-0.3	-0.5	-0.3	-0.8	-0.9	-0.6
Osteoporosis (self-reported)	0.9	1.1	3.2	-0.1	-0.1	-1.3	-1.4	-1.8	-1.0	-0.2
Osteoarthritis (self-reported)	0.6	0.8	2.6	-0.7	0.4	1.6	-0.2	1.2	0.6	0.9
Medication: Aspirin	1.4	1.8	5.8	0.6	-0.8	-1.8	-0.6	-2.4	-1.0	-1.1
Medication: Gliclazide	0.6	0.7	1.4	-1.0	1.2	0.6	-0.4	-0.1	1.0	1.0
Illnesses of father: None of the above (group 1)	2.3	2.8	5.2	-2.2	2.2	0.6	-1.1	0.7	1.7	2.3
Smoking status: Current	0.2	0.3	0.7	-0.2	0.9	-0.3	0.2	-0.2	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.5	0.6	-0.7	-1.4	-1.0	-1.5	-1.6	-0.7
Whole body water mass	0.9	5.1	8.4	-2.3	2.9	2.0	-0.7	2.2	2.1	2.9
Leg predicted mass (right)	0.7	3.6	7.0	-2.3	2.6	0.6	-1.9	0.7	1.3	2.6
Arm fat mass (left)	0.9	3.9	10.2	-2.2	2.1	-1.1	-3.2	-1.5	0.3	2.0
Number of self-reported non-cancer illnesses	0.8	1.4	3.7	1.1	-0.7	-1.3	-0.1	-1.9	-1.0	-1.2
Average weekly champagne plus white wine intake	0.6	0.9	3.0	1.0	-1.0	-0.7	-0.4	-0.0	-1.7	-0.7
Miserableness	0.5	0.9	1.7	0.8	-0.6	-1.3	-0.7	-1.1	-1.2	-0.6
Guilty feelings	2.5	3.7	6.7	2.5	-2.2	-1.4	0.8	-0.9	-2.6	-2.2
Wears glasses or contact lenses	2.2	2.5	5.8	1.1	-1.6	-1.6	-1.0	-1.6	-2.4	-1.3
Ever taken oral contraceptive pill	0.6	0.7	1.6	-0.9	1.0	0.0	-1.3	-0.3	0.3	1.0
Hearing aid user	0.4	0.4	1.5	-0.3	0.4	-0.8	-0.4	-1.2	0.5	0.2
Mother’s age at death	2.3	2.8	5.2	2.1	-2.3	-0.9	1.4	0.2	-1.7	-2.2
Financial situation satisfaction	0.7	0.9	3.7	-0.4	0.6	-1.1	-0.5	-1.9	0.7	0.0
Tinnitus: Yes, now most or all of the time	3.6	4.2	8.4	1.9	-1.9	-2.9	0.3	-2.3	-1.4	-2.4
Commuting to job workplace: Public transport	2.2	2.7	5.4	2.3	-1.6	-1.2	1.3	-0.7	-1.7	-2.0
Eye problems/disorders: Glaucoma	0.7	0.8	1.5	-0.8	0.9	0.9	0.1	0.7	1.2	1.1
Medication: Blood pressure	0.8	1.6	3.2	-1.6	1.5	0.3	-1.8	-0.6	0.8	1.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.4	0.6	-0.6	-1.7	-0.9	-1.8	-1.2	-0.8
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.8	-1.0	0.9	1.9	0.4	1.6	1.2	1.1
High cholesterol (Self-reported)	0.3	0.6	2.5	0.1	-0.3	-0.9	-0.7	-1.6	-0.4	-0.4
Medication: Bendroflumethiazide	0.6	0.8	2.3	-1.0	1.0	0.3	-1.5	-0.6	0.3	1.0
Medication: Paracetamol	1.0	1.6	3.1	-1.5	1.7	0.3	-1.6	-0.5	0.5	1.7
Medication: Lisinopril	0.7	0.9	1.8	1.2	-1.3	-0.3	0.5	0.2	-1.2	-1.1
Medication: Atorvastatin	0.6	0.8	2.4	0.6	-0.1	-1.5	0.1	-1.5	-0.2	-0.4
Illnesses of father: High blood pressure	1.3	1.6	3.0	-1.6	1.6	1.0	-0.9	0.4	1.2	1.7
Alcohol drinker status: Never	0.6	0.7	2.5	0.2	-0.2	-1.6	-0.5	-1.4	0.1	-0.4
Ever smoked	1.4	2.5	4.8	2.2	-1.5	-1.3	0.8	-1.1	-1.9	-1.9
Basal metabolic rate	1.0	5.8	10.6	-2.8	3.2	1.6	-1.5	1.6	2.1	3.2
Leg fat percentage (left)	0.6	2.3	3.9	-1.6	1.8	-1.0	-2.0	-1.6	0.8	1.5
Arm fat-free mass (left)	1.0	5.1	8.9	-2.3	3.0	1.9	-0.6	2.0	2.3	2.9
Number of operations (self-reported)	0.7	1.1	3.4	0.6	-0.6	-1.8	-0.6	-1.3	-0.8	-0.9
Average weekly beer plus cider intake	1.1	1.6	4.1	-0.6	0.6	-1.5	-2.0	-1.8	-0.8	0.5
Irritability	0.6	1.0	1.8	0.5	-0.1	-1.1	-1.2	-1.3	-1.3	-0.3
Risk taking	0.3	0.5	1.7	-0.0	-0.4	-0.3	-1.1	-0.3	-1.3	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.6	1.2	-0.9	0.3	1.3	0.8	-0.6	-1.0
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.9	-0.5	-0.8	0.0	-0.7	-0.9	-0.7
Age started oral contraceptive pill	0.2	0.2	0.6	0.8	-0.2	0.2	0.6	-0.5	-0.2	-0.6
Diastolic blood pressure, automated reading	1.2	3.9	7.9	-2.6	2.3	0.5	-2.1	0.6	1.4	2.8
Ever depressed for a whole week	0.1	0.2	0.5	-0.0	0.4	-0.4	-0.6	-0.7	-0.2	0.2
Unable to work because of sickness or disability	0.2	0.2	0.9	-0.2	0.3	-0.2	0.6	-0.2	0.9	0.0
Commuting to job workplace: Cycle	0.4	0.4	1.0	0.1	-0.2	-1.0	-0.8	-1.0	-0.5	-0.2
Myopia	0.1	0.2	0.5	-0.5	0.3	0.3	-0.4	-0.7	0.3	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.0	-0.1	0.1	0.5	0.4	0.3	-0.0
Cholesterol lowering medication	1.1	1.6	3.1	-1.8	1.3	0.7	-0.9	0.0	1.6	1.5
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	4.0	-1.6	1.2	2.0	-0.9	1.0	0.8	1.7
Pain experienced in last month	0.2	0.4	0.9	0.2	-0.7	0.5	0.9	0.5	0.6	-0.7
Supplements: Calcium	0.3	0.3	0.7	-0.4	0.2	-0.6	-0.9	-0.7	-0.3	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	0.4	-0.0	-0.2	0.2	0.5	0.4
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.0	0.3	-0.6	-1.8	-0.9	-2.0	-1.2	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.5	1.4	-1.1	0.4	2.1	1.6	0.1	-1.2
Heart disease (siblings)	1.0	1.2	2.5	0.8	-0.7	1.6	1.5	1.5	-0.1	-0.5
Alcohol drinker status: Previous	0.7	0.8	1.6	1.2	-1.1	-0.1	0.6	0.4	-1.3	-0.9
Pack years of smoking	0.8	1.1	1.8	1.3	-1.3	-0.4	0.7	-0.4	-1.3	-1.3
Impedance of whole body	0.6	3.1	6.8	-2.3	1.5	-0.9	-2.6	-1.6	1.0	1.7
Leg fat mass (left)	1.0	4.1	6.9	-2.5	2.6	-0.5	-2.6	-0.9	1.3	2.5
Arm predicted mass (left)	1.2	6.0	9.9	-2.4	3.1	2.2	-0.4	2.4	2.5	3.0