Hub : Genes

NCRNA00174

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.1830	0.0990	4.8e-04	0.053	0.051	0.047	NA	0.053	5.2e-04	6.3e-04	1.0e-03	NA	5.2e-04
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.2349	0.0812	0.0e+00	0.321	0.303	0.312	NA	0.318	7.7e-37	2.1e-34	1.2e-35	NA	1.9e-36
3	TCGA	Lung Squamous Cell Carcinoma	0.0596	0.0350	6.7e-07	0.045	0.064	0.062	NA	0.061	7.2e-06	9.0e-08	1.4e-07	NA	1.6e-07
4	TCGA	Prostate Adenocarcinoma	0.1447	0.0663	3.1e-04	0.049	0.050	0.045	NA	0.047	6.3e-06	6.0e-06	1.7e-05	NA	9.5e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.5	2.4	4.1	-1.5	1.8	2.0	0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	-1.2	0.9	1.3	0.2
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-0.9	0.6	0.7	-0.5
Depression (Nagel 2018)	2.1	3.2	6.5	-2.4	0.8	0.0	-2.5
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.3	-1.4	2.2	2.3	0.2
Neuroticism (Nagel 2018)	0.5	1.3	2.2	-1.5	1.0	0.8	-1.0
Schizophrenia (2018)	0.0	0.0	0.1	-0.3	-0.3	0.1	0.0
Schizophrenia vs Biploar Disorder	2.6	3.4	4.6	2.1	-2.2	-1.9	0.8
Worry (Nagel 2018)	0.1	0.1	0.2	-0.4	0.2	0.2	-0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.4	-0.4	-0.8	-0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	0.5	0.1	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.1	-0.7	-0.2	-0.7	-1.0
Crohns Disease (2017)	0.2	0.4	0.8	0.4	-0.9	-0.6	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.3	-0.8	-0.1	0.1
Ulcerative Colitis (UC)	0.2	0.5	0.7	0.6	-0.9	0.1	0.9
Major Depression (MDD)	1.9	2.3	4.6	-2.1	1.3	0.4	-1.6
Reaction Time	0.9	1.7	2.4	-1.5	1.3	1.4	-1.0
Verbal and Numeric Reasoning (VNR)	3.6	8.7	15.3	-2.5	3.6	3.9	0.4
Breast Cancer	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.1
Ovarian Cancer	0.6	0.8	1.8	-0.9	0.4	-0.6	-1.4
Prostate Cancer	1.1	1.5	2.0	-1.4	1.3	0.8	-1.4
Age at First Birth	0.3	0.5	1.2	0.2	0.2	0.8	1.1
Bipolar Disorder (2011)	2.2	2.1	3.3	-1.5	1.7	1.8	0.2
Body Mass Index (BMI) (2010)	1.4	1.9	3.9	-1.6	0.9	-0.1	-2.0
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.4	-0.4	0.1	0.3
Crohns Disease (2012)	0.1	0.2	0.6	-0.1	0.1	0.8	0.3
Mean Putamen Volume	1.1	1.3	1.9	1.3	-1.2	-1.4	0.2
Fasting Glucose	0.2	0.2	0.4	-0.5	0.2	-0.3	-0.6
HbA1C	0.8	0.9	2.7	-0.8	-0.3	-0.5	-1.7
HDL Cholesterol	0.6	0.9	1.5	1.2	-0.8	0.0	1.2
LDL Cholesterol	2.3	3.6	4.9	2.2	-2.2	-2.2	0.2
Lupus	1.2	1.8	3.1	-1.2	1.4	1.8	0.7
Neuroticism (2016)	0.0	0.1	0.1	0.2	0.1	-0.3	-0.3
Primary Biliary Cirrhosis	0.8	1.1	2.0	-1.4	0.7	0.5	-1.4
Rheumatoid Arthritis	0.4	0.6	1.2	1.1	-0.8	-0.4	0.6
Schizophrenia (2014)	0.0	0.0	0.1	-0.1	-0.0	0.3	0.2
Triglycerides	2.0	3.3	5.2	-2.3	2.0	1.4	-1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	-0.2	0.8	1.0	0.7
Ulcerative Colitis	0.1	0.1	0.2	-0.1	-0.2	0.4	0.3
Blood Eosinophil Count	0.7	5.2	13.2	-2.3	0.8	-1.3	-3.6
Blood Platelet Count	0.3	3.5	7.1	1.2	-1.9	-2.7	-1.3
Blood Red Count	0.0	0.5	0.8	-0.0	0.9	0.7	0.8
Blood White Count	2.4	18.0	37.5	-1.1	-3.1	-4.9	-6.1
Heel T-Score	0.8	6.5	10.9	-2.6	2.8	3.3	-0.6
BMI	0.7	3.8	9.5	-1.6	0.1	-1.8	-3.1
Height	2.2	42.3	65.9	6.7	-7.4	-8.1	1.9
Waist Hip Ratio (WHR)	0.0	0.2	0.3	0.5	-0.5	-0.5	0.1
Systolic Blood Pressure	0.5	2.7	4.3	2.1	-1.7	-1.8	0.8
Smoking Status	1.1	2.5	6.4	-1.7	0.9	-0.3	-2.5
Allergy or Eczema	0.0	0.1	0.2	0.3	-0.4	0.5	0.2
Cardiovascular Disease	0.0	0.1	0.3	0.0	-0.1	-0.2	-0.6
Hypothyroidism (self reported)	1.1	2.6	7.1	-1.5	0.5	-0.8	-2.7
Respiratory disease	0.6	1.3	3.6	-1.1	0.4	-0.3	-1.9
Type 2 Diabetes (T2D) (2018)	1.8	3.4	6.4	0.7	-2.1	-2.5	-1.6
Lung FEV1/FVC ratio	0.8	4.1	9.3	-0.2	-1.3	-3.0	-2.3
Lung FVC	1.7	8.7	19.4	-1.3	2.8	4.4	2.4
Neuroticism	0.3	0.6	1.1	-1.1	0.8	0.7	-0.5
Chronotype (morning person)	0.5	1.2	3.5	-0.9	0.1	-0.7	-1.9
Hair Pigment	0.1	2.4	3.2	-1.8	1.8	1.7	-0.6
Tanning	0.2	2.4	4.2	-1.5	1.8	2.0	0.4
Hand grip strength (left)	0.5	1.4	2.0	1.4	-1.1	-1.4	0.8
Number of treatments/medications taken	0.3	0.5	1.6	-0.2	-0.5	-0.4	-1.3
Average weekly spirits intake	1.1	1.4	2.5	0.8	-1.4	-1.6	-0.6
Sensitivity / hurt feelings	0.5	0.8	2.0	-0.7	0.0	-0.9	-1.4
Frequency of depressed mood in last 2 weeks	1.7	2.3	4.5	-2.1	0.9	0.2	-2.0
Hearing difficulty/problems: Yes	3.6	5.6	9.3	-3.0	2.7	1.8	-1.6
Relative age of first facial hair	0.7	1.3	3.3	-0.2	0.6	1.8	1.3
Other serious medical condition/disability diagnosed by doctor	3.5	4.6	6.8	-2.3	2.6	2.3	-1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.1	-1.8	1.4	0.5	-1.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	-0.7	1.1	1.4	0.4
Systolic blood pressure, automated reading	0.3	1.0	1.4	1.2	-1.0	-1.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	0.3	-0.9	-1.2	-0.7
Angina	1.4	1.8	3.6	-1.9	1.3	0.8	-1.2
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.5	0.4	0.4	-0.3
Vitamin and mineral supplements	0.6	0.9	1.5	-1.2	0.8	0.3	-1.1
Supplements: Zinc	0.6	0.6	1.1	-0.5	1.0	1.0	0.3
Medication: Co-codamol	2.3	2.6	4.2	-1.8	2.1	1.6	-0.6
Medication: Metformin	1.5	2.2	3.6	1.2	-1.8	-1.9	-0.7
Diabetes (father)	0.9	1.1	1.8	1.4	-1.1	-0.6	1.0
Diabetes (mother)	0.1	0.1	0.3	-0.2	0.4	0.2	-0.5
Severe depression (siblings)	0.4	0.5	1.2	-0.5	0.5	1.1	0.5
Pack years adult smoking proportion	0.6	0.9	2.1	-0.6	1.0	1.4	0.3
Impedance of leg (right)	0.5	2.6	4.3	1.6	-2.1	-1.9	-0.1
Leg fat-free mass (left)	1.1	6.1	14.2	1.8	-2.6	-3.8	-0.4
Trunk fat percentage	1.4	5.5	10.8	-0.5	-1.5	-3.3	-2.9
Hand grip strength (right)	0.2	0.5	0.8	0.7	-0.5	-0.9	0.5
Townsend deprivation index at recruitment	1.0	1.5	3.2	-1.5	0.6	-0.1	-1.8
Current tobacco smoking	0.1	0.1	0.3	-0.1	0.0	-0.3	-0.5
Average weekly fortified wine intake	1.6	1.9	3.0	-1.5	1.7	1.4	-0.6
Maternal smoking around birth	2.7	3.9	10.4	-1.8	0.5	-1.2	-3.2
Fed-up feelings	0.2	0.4	0.6	-0.7	0.5	0.8	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	9.6	-2.4	0.8	-0.3	-3.1
Relative age voice broke	0.3	0.5	1.0	-0.6	0.8	1.0	-0.1
Taking other prescription medications	0.8	1.2	1.8	-1.2	0.6	1.4	-1.0
Age when periods started (menarche)	0.5	1.3	3.3	1.2	-0.6	0.1	1.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.8	-1.3	0.8	0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.0	0.3	0.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.3	-0.2	-0.1	0.2
Qualifications: CSEs or equivalent	0.4	0.5	0.9	0.9	-0.7	-0.5	0.6
Serious illness, injury or assault to yourself	0.8	0.9	1.3	-1.2	1.1	0.7	-0.7
High blood pressure	0.0	0.1	0.3	0.5	-0.5	-0.2	-0.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	0.6	-0.8	-0.1	0.1
Multivitamins +/- minerals	0.3	0.4	0.9	0.3	0.2	0.8	1.0
Stomach or abdominal pain in last month	0.1	0.2	0.2	0.5	-0.4	-0.5	0.3
Supplements: Glucosamine	1.8	2.3	3.5	1.9	-1.4	-1.0	1.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.2	0.1	0.1	-0.4
Medication: Atenolol	0.0	0.0	0.1	0.2	-0.3	-0.1	0.2
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.7	-0.5	-1.1	-0.2
Sitting height	0.6	4.3	9.9	1.6	-2.1	-3.1	-0.2
Chronic bronchitis/emphysema (father)	1.5	1.7	3.2	-1.0	1.5	1.8	0.4
High blood pressure (mother)	1.6	2.2	4.2	1.9	-1.1	-0.3	2.1
Body mass index (BMI)	0.2	0.9	1.9	-0.7	-0.0	-1.1	-1.4
Impedance of leg (left)	0.4	2.0	3.1	1.4	-1.8	-1.7	-0.2
Leg predicted mass (left)	1.2	6.3	14.7	1.9	-2.6	-3.8	-0.4
Trunk fat mass	1.6	6.7	16.2	0.6	-2.3	-4.0	-2.2
Waist circumference	0.9	3.4	8.4	0.9	-1.8	-2.9	-1.1
Number of incorrect matches in round	0.0	0.1	0.2	0.2	-0.3	-0.4	0.1
Past tobacco smoking	1.9	3.4	5.1	2.3	-1.7	-0.9	2.2
Alcohol usually taken with meals	2.0	3.2	5.7	0.1	1.3	2.3	2.4
Nervous feelings	0.3	0.6	1.0	-1.0	0.8	0.5	-0.7
Frequency of tenseness / restlessness in last 2 weeks	3.1	4.8	8.9	-3.0	1.8	0.9	-2.5
Hearing difficulty/problems with background noise	5.0	7.9	14.2	-3.8	2.6	1.4	-3.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.2	0.1	0.0	-0.1
Had menopause	0.9	1.1	1.9	-1.4	1.0	0.9	-0.9
Had other major operations	0.6	0.7	1.1	-1.1	1.0	0.9	-0.2
Forced vital capacity (FVC)	0.6	2.2	2.9	1.7	-1.7	-1.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	-0.7	0.8	1.1	0.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.3	0.2	0.2	0.1
Qualifications: None of the above	0.9	2.0	4.0	0.4	-1.4	-2.0	-1.3
Financial difficulties in last 2 years	3.8	5.1	10.0	-2.7	1.7	-0.1	-3.2
Mouth/teeth dental problems	2.0	3.1	5.1	2.0	-2.3	-1.4	1.0
Heart attack	0.9	1.2	2.2	-1.5	1.0	0.6	-1.1
Allergy	0.0	0.0	0.2	-0.2	0.0	-0.4	-0.1
Pain all over the body in last month	1.0	1.1	1.7	1.3	-1.0	-0.5	1.1
Diabetes (self-reported)	1.0	1.6	3.7	-0.6	-0.5	-1.4	-1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.1	0.3	0.7	0.7
Medication: Ramipril	0.9	1.1	1.6	-0.0	-1.2	-1.2	-1.2
Medication: Simvastatin	2.0	2.9	5.2	1.6	-2.3	-2.0	-0.1
Fluid intelligence score	2.1	4.3	9.0	-1.5	2.3	3.0	0.6
Illnesses of siblings	0.5	0.7	1.4	-1.2	0.5	-0.0	-1.2
Neuroticism score	0.3	0.6	1.1	-1.1	0.7	0.4	-0.7
Weight	1.3	6.6	16.0	1.6	-2.6	-4.0	-0.9
Impedance of arm (right)	0.6	2.6	5.1	-0.5	-1.2	-1.9	-2.3
Arm fat percentage (right)	0.8	3.2	6.6	-1.0	-0.6	-2.2	-2.6
Trunk fat-free mass	1.6	9.4	12.5	3.5	-3.2	-3.4	1.8
Hip circumference	1.0	4.1	10.3	1.0	-2.0	-3.2	-1.2
Time employed in main current job	0.9	1.1	2.0	1.4	-1.1	-0.4	1.1
Alcohol intake versus 10 years previously	1.3	1.9	2.8	-1.7	1.5	1.5	-0.6
Father’s age at death	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.3
Worrier / anxious feelings	0.5	0.9	1.7	-1.3	0.4	0.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	9.2	-1.9	0.6	-0.9	-3.0
Falls in the last year	1.2	1.6	2.7	-1.6	1.0	0.4	-1.6
Hair/balding pattern: Pattern 3	3.9	5.7	8.0	2.8	-2.8	-2.5	1.0
Number of live births	1.1	1.6	2.9	-0.0	-0.9	-1.7	-1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	3.7	1.8	-1.9	-1.7	0.8
Pulse rate	2.2	3.7	5.5	2.0	-2.4	-2.3	0.2
Happiness	3.1	3.7	6.2	-1.7	2.4	2.5	0.2
Noisy workplace	0.7	0.8	1.7	-1.1	0.7	-0.0	-1.3
Qualifications: A levels/AS levels or equivalent	1.3	2.8	6.6	0.6	0.6	2.0	2.6
Serious illness, injury or assault of a close relative in last 2 years	4.9	5.6	8.0	-2.7	2.8	2.4	-1.0
Mouth/teeth dental problems: Dentures	3.8	6.5	11.0	-2.5	3.3	3.0	-0.2
Asthma	0.2	0.5	0.7	-0.8	0.6	0.8	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	2.6	-1.6	1.2	0.8	-1.5
Medication: Cholesterol lowering	0.2	0.3	0.4	-0.6	0.4	0.5	-0.6
Depression (self-reported)	1.4	1.7	2.1	-1.3	1.5	1.4	-1.0
Medication: Lansoprazole	0.7	0.8	1.3	1.0	-1.2	-0.8	0.4
Prospective memory result	1.6	1.9	4.5	-0.6	-0.3	-1.6	-2.1
Lung cancer (father)	0.1	0.2	0.6	0.3	-0.1	-0.8	-0.0
Illnesses of mother	0.3	0.4	0.7	0.4	-0.8	-0.8	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	0.6	-0.7	-0.9	0.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.4	-0.1	-0.0	0.7
Impedance of arm (left)	0.5	2.1	4.9	-0.7	-0.9	-1.5	-2.2
Arm fat mass (right)	0.9	3.5	8.3	-0.1	-1.3	-2.9	-2.0
Trunk predicted mass	1.7	9.5	12.7	3.6	-3.2	-3.4	1.9
Standing height	2.4	23.6	38.2	4.9	-5.6	-6.2	1.1
Length of working week for main job	1.5	1.6	3.0	-1.0	1.5	1.7	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.1	-0.6	-0.4	-0.1
Breastfed as a baby	2.2	2.8	4.9	-1.4	2.0	2.2	0.4
Tense / ‘highly strung’	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.6	-1.3	0.9	0.8	-1.1
Hair/balding pattern: Pattern 4	4.1	9.8	14.2	-3.7	3.8	2.9	-1.8
Birth weight of first child	0.8	1.5	2.5	1.2	-1.6	-1.4	0.4
Peak expiratory flow (PEF)	0.2	0.4	1.0	0.7	-0.3	-0.1	1.0
Pulse wave reflection index	0.2	0.2	0.4	-0.6	0.6	0.0	-0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-0.6	-0.4	-1.2	-1.5
Loud music exposure frequency	0.5	0.6	1.0	-1.0	0.8	0.3	-0.7
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	6.4	0.4	1.0	2.4	2.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	-0.5	0.1	-0.4	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.1	0.5	0.6	0.4	1.0
Medication: Paracetamol	0.2	0.3	1.1	-0.2	-0.3	-0.2	-1.0
Headache pain in last month	0.2	0.4	0.6	-0.7	0.8	0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.2	-0.1	-0.1	0.3
Glaucoma (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0
Gout (self-reported)	0.0	0.1	0.2	-0.1	-0.0	0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.7	-0.7	0.3	-0.7	-1.6
Medication: Amlodipine	0.1	0.1	0.2	0.5	-0.3	-0.1	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.5	-0.5	-0.4	0.2
Birth weight	1.2	2.6	4.2	1.4	-2.1	-2.0	0.2
Chronic bronchitis/emphysema (mother)	1.4	1.7	3.2	0.3	-1.3	-1.8	-1.3
High blood pressure (siblings)	0.7	1.1	2.1	1.5	-0.8	-0.4	1.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	0.5	-0.3	-0.0	0.8
Body fat percentage	1.1	4.4	9.4	-0.2	-1.4	-3.1	-2.5
Leg fat percentage (right)	0.7	2.6	5.3	-0.2	-1.1	-2.3	-2.0
Arm fat-free mass (right)	1.4	7.2	11.2	2.9	-2.8	-3.3	1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.7	-0.9	-0.6	0.0
Comparative body size at age 10	0.8	2.2	4.1	2.0	-1.4	-0.7	1.5
Number of full brothers	0.9	1.1	2.2	-0.5	1.2	1.5	0.7
Worry too long after embarrassment	0.1	0.2	0.4	-0.6	0.4	-0.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.9	-2.0	1.4	1.0	-1.6
Wheeze or whistling in the chest in last year	0.8	1.5	2.1	-1.5	1.3	0.8	-1.2
Number of children fathered	1.1	1.2	2.6	-0.5	1.0	1.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.8	0.4	0.1	-1.0
Age at first live birth	0.7	1.3	2.6	-1.0	1.3	1.6	0.4
Pulse wave peak to peak time	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.5
Health satisfaction	0.8	1.1	1.9	-0.0	-0.8	-1.4	-1.4
Shortness of breath walking on level ground	4.1	4.9	11.7	-1.0	-0.8	-2.5	-3.4
Qualifications: College or University degree	0.4	1.4	2.4	-0.7	1.5	1.5	0.8
Eye problems/disorders: None of the above	0.6	0.7	1.5	0.3	0.6	0.9	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.4	1.0	0.6	0.0
Emphysema/chronic bronchitis	0.9	1.0	1.9	0.0	-0.6	-1.3	-1.4
Medication for pain relief, constipation, heartburn	1.1	1.8	3.4	1.7	-0.7	-0.8	1.8
Neck or shoulder pain in last month	0.6	0.9	1.6	-1.3	0.7	0.1	-1.2
Medication: Blood pressure	0.2	0.4	0.8	0.9	-0.7	-0.0	0.7
Angina (self-reported)	1.2	1.6	3.1	-1.8	1.2	0.8	-1.0
Migraine (self-reported)	3.9	4.9	8.5	-2.2	2.5	2.9	-0.1
Medication: Ibuprofen	1.8	2.1	4.0	-1.8	1.1	0.5	-2.0
Medication: Allopurinol	0.1	0.1	0.2	0.1	-0.5	-0.2	0.1
Medication: Omeprazole	1.2	1.4	2.6	1.3	-1.6	-0.7	0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.0	1.0	-0.9	-1.0	0.2
Mean time to correctly identify matches	0.9	1.7	2.4	-1.5	1.2	1.4	-1.0
Heart disease (mother)	0.8	1.0	2.2	-0.6	1.1	1.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.4	-0.1	-0.3	0.3
Whole body fat mass	1.4	6.0	15.1	0.8	-2.2	-3.9	-1.9
Leg fat mass (right)	1.2	4.5	11.4	0.6	-1.8	-3.4	-1.7
Arm predicted mass (right)	1.5	7.7	12.5	3.0	-2.9	-3.5	0.9
Pulse rate, automated reading	0.9	3.0	5.3	1.5	-2.0	-2.3	-0.6
Alcohol intake frequency.	1.0	2.3	3.8	-1.8	1.9	1.5	-0.4
Comparative height size at age 10	3.1	16.8	23.1	4.5	-4.7	-4.8	1.4
Number of full sisters	0.2	0.2	0.3	-0.5	0.2	0.4	-0.5
Suffer from ‘nerves’	0.1	0.2	0.4	0.2	-0.6	-0.4	-0.6
Overall health rating	1.4	3.1	5.5	-0.0	-1.4	-2.4	-2.2
Chest pain or discomfort	0.4	0.6	0.8	-0.9	0.8	0.7	-0.6
Had major operations	0.9	1.0	2.3	0.3	-0.6	-1.5	-1.2
Age at last live birth	1.1	1.6	2.6	-1.6	1.4	0.9	-1.0
Family relationship satisfaction	2.2	2.7	4.2	-2.0	1.9	1.6	-0.8
Leg pain on walking	2.8	3.5	5.4	2.0	-2.3	-2.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	3.6	4.3	7.2	2.7	-2.3	-1.4	1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	0.9	-0.9	-0.7	0.2
Illness, injury, bereavement, stress in last 2 years	5.8	7.1	10.8	2.9	-3.3	-2.9	0.9
Medication: Aspirin	1.8	2.4	3.9	-2.0	1.5	1.5	-1.1
Supplements: Vitamin C	0.4	0.4	1.1	0.4	-0.0	0.7	1.1
Knee pain experienced in last month	1.7	2.7	4.0	2.0	-2.0	-1.4	1.0
Hypertension (Self-reported)	0.2	0.7	1.2	1.1	-1.1	-0.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.4	-0.6	0.2	0.6
Illnesses of father: Heart disease	1.1	1.5	3.7	-0.6	1.1	1.9	0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.5	-0.7	-0.9	-0.3
Smoking status: Previous	1.8	2.8	7.0	-1.8	0.8	-0.4	-2.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.2	1.3	-1.7	-2.5	-0.3
Whole body fat-free mass	1.4	7.8	13.0	2.9	-3.0	-3.6	1.0
Leg fat-free mass (right)	0.9	4.9	11.7	1.7	-2.3	-3.4	-0.3
Arm fat percentage (left)	0.8	3.1	6.4	-0.9	-0.6	-2.2	-2.5
Average weekly red wine intake	0.6	0.9	2.1	-0.1	-0.2	-1.4	-1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	0.8	-0.3	0.2	1.1
Mood swings	0.1	0.2	0.4	-0.6	0.0	0.2	-0.6
Loneliness, isolation	1.3	1.7	2.5	-1.6	1.6	1.3	-0.5
Long-standing illness, disability or infirmity	2.5	3.9	6.0	-2.5	1.9	1.3	-2.0
Ever had bowel cancer screening	0.0	0.0	0.0	-0.0	-0.1	-0.2	-0.2
Diabetes diagnosed by doctor	1.7	2.7	5.0	0.3	-1.5	-2.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.1	0.4	-0.1	0.3
Friendships satisfaction	2.1	2.6	4.2	-1.5	2.0	2.0	-0.2
Qualifications: nursing, teaching	3.6	5.6	8.4	-2.4	2.9	2.8	-0.3
Commuting to job workplace: Walk	0.6	0.6	0.9	-0.9	0.9	0.9	-0.3
Eye problems/disorders: Cataract	2.0	2.4	4.2	1.2	-2.1	-1.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	0.2	-0.1	-0.9	-0.1
Medication for cholesterol	0.2	0.3	0.6	-0.7	0.7	0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	-0.7	0.1	-0.2	-1.5
Back pain experienced in last month	1.0	1.5	3.4	-1.5	0.4	-0.1	-1.9
Mineral and other dietary supplements	2.0	2.8	4.5	-2.1	1.8	0.9	-1.6
Breast cancer (self-reported)	0.5	0.6	1.7	0.6	-0.1	0.5	1.3
Asthma (self-reported)	0.3	0.6	0.9	-0.9	0.7	0.9	-0.6
Osteoporosis (self-reported)	0.9	1.1	2.0	-1.4	0.6	0.3	-1.4
Osteoarthritis (self-reported)	0.8	1.0	1.7	1.3	-1.1	-0.5	1.0
Medication: Aspirin	2.1	2.8	4.8	-2.2	1.6	1.3	-1.5
Medication: Gliclazide	0.4	0.4	0.7	0.5	-0.9	-0.7	-0.3
Illnesses of father: None of the above (group 1)	3.0	3.7	7.4	1.6	-2.2	-2.7	-0.0
Smoking status: Current	0.1	0.2	0.5	-0.1	-0.0	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.8	-1.3	1.1	0.9	-0.7
Whole body water mass	1.3	7.4	12.2	2.8	-2.9	-3.5	0.9
Leg predicted mass (right)	0.9	5.0	11.8	1.7	-2.3	-3.4	-0.3
Arm fat mass (left)	0.8	3.1	7.4	-0.1	-1.2	-2.7	-1.9
Number of self-reported non-cancer illnesses	1.7	3.0	4.4	-2.1	1.7	1.7	-1.4
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.6	0.8	0.8	0.3
Miserableness	0.7	1.1	1.9	-1.4	1.2	0.5	-1.0
Guilty feelings	2.9	4.3	6.6	-2.1	2.6	2.5	0.1
Wears glasses or contact lenses	2.2	2.5	3.9	-2.0	1.7	1.7	-0.6
Ever taken oral contraceptive pill	0.3	0.4	0.6	0.3	-0.7	-0.8	-0.6
Hearing aid user	0.5	0.6	1.7	-0.8	0.3	-0.2	-1.3
Mother’s age at death	1.5	1.9	3.5	-0.9	1.7	1.9	0.8
Financial situation satisfaction	0.9	1.1	2.8	-1.1	0.4	-0.0	-1.7
Tinnitus: Yes, now most or all of the time	4.4	5.1	8.2	-2.9	2.6	1.6	-1.8
Commuting to job workplace: Public transport	3.3	3.9	5.8	-2.0	2.4	2.4	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	0.9	-1.0	-0.7	0.4
Medication: Blood pressure	0.5	1.0	1.8	0.5	-1.1	-1.4	-0.9
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.8	-1.7	1.2	0.7	-1.4
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.7	1.9	-1.6	-0.6	1.5
High cholesterol (Self-reported)	0.5	0.9	1.3	-1.1	0.7	0.7	-1.1
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.1	-0.6	-0.4	-0.9
Medication: Paracetamol	0.6	0.9	1.2	0.5	-1.1	-1.1	-1.0
Medication: Lisinopril	0.5	0.6	1.1	-0.5	1.0	1.0	0.3
Medication: Atorvastatin	1.5	1.9	3.3	-1.6	1.2	0.4	-1.8
Illnesses of father: High blood pressure	1.2	1.5	2.3	1.2	-1.5	-1.5	-0.0
Alcohol drinker status: Never	1.1	1.3	3.2	-1.2	0.7	-0.2	-1.8
Ever smoked	2.6	4.5	6.4	-2.2	2.5	2.5	-0.8
Basal metabolic rate	1.5	8.1	15.8	2.7	-3.1	-4.0	0.4
Leg fat percentage (left)	0.6	2.0	4.0	-0.3	-0.8	-2.0	-1.9
Arm fat-free mass (left)	1.3	6.8	12.0	2.6	-2.8	-3.5	0.7
Number of operations (self-reported)	0.8	1.1	1.8	-1.3	1.0	-0.1	-1.3
Average weekly beer plus cider intake	0.8	1.2	3.3	-1.0	0.2	-0.5	-1.8
Irritability	0.6	1.0	1.7	-1.3	1.0	0.5	-1.0
Risk taking	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.2	-0.1	0.7	1.0	1.1
Fractured/broken bones in last 5 years	0.7	0.8	1.2	-1.1	1.1	0.9	-0.4
Age started oral contraceptive pill	0.7	0.9	1.7	-0.9	0.9	1.3	-0.2
Diastolic blood pressure, automated reading	1.6	5.1	11.3	1.7	-2.4	-3.4	-0.7
Ever depressed for a whole week	0.1	0.1	0.3	-0.6	0.3	0.0	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	0.1	-0.1	-0.5	-0.4
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.9	0.5	0.0	-0.9
Myopia	0.0	0.1	0.1	-0.1	-0.3	0.3	0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.3	-0.2	-0.2	0.6
Cholesterol lowering medication	1.1	1.6	2.5	1.1	-1.5	-1.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.3	1.7	-1.8	-0.6	1.3
Pain experienced in last month	0.2	0.3	0.7	0.4	-0.1	0.5	0.8
Supplements: Calcium	0.2	0.2	0.5	-0.4	-0.0	-0.4	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.4	-0.5	-0.9	-0.3
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.9	-1.7	1.1	0.7	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.6	0.5	0.4	1.2
Heart disease (siblings)	1.1	1.4	3.3	0.9	0.0	1.1	1.8
Alcohol drinker status: Previous	0.5	0.6	1.1	-0.3	0.9	1.0	0.5
Pack years of smoking	0.9	1.4	3.0	-0.9	1.3	1.7	0.2
Impedance of whole body	0.4	2.0	3.4	0.1	-1.4	-1.9	-1.7
Leg fat mass (left)	1.1	4.4	10.9	0.7	-1.8	-3.3	-1.6
Arm predicted mass (left)	1.6	8.3	13.6	3.0	-3.1	-3.7	1.0