Hub : Genes

TPST1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0380	0.0230	9.1e-04	0.027	NA	0.025	NA	0.028	2.7e-03	NA	3.7e-03	NA	2.4e-03
2	GTEx	Colon Sigmoid	0.0530	0.0340	7.2e-03	0.033	NA	0.044	NA	0.054	2.5e-02	NA	1.2e-02	NA	5.6e-03
3	GTEx	Esophagus Mucosa	0.0660	0.0330	1.3e-05	0.070	NA	0.088	NA	0.084	2.0e-05	NA	1.7e-06	NA	3.0e-06
4	GTEx	Heart Left Ventricle	0.0877	0.0562	6.5e-03	0.100	NA	0.062	NA	0.082	5.7e-06	NA	3.2e-04	NA	4.0e-05
5	GTEx	Lung	0.0961	0.0467	3.4e-04	0.050	NA	0.058	NA	0.056	1.0e-04	NA	2.9e-05	NA	4.0e-05
6	GTEx	Thyroid	0.0650	0.0330	9.6e-05	0.019	NA	0.056	NA	0.036	1.3e-02	NA	4.3e-05	NA	9.1e-04
7	METSIM	Adipose	0.0476	0.0361	4.8e-03	0.006	0.022	0.017	0.023	0.009	3.7e-02	2.6e-04	9.8e-04	1.7e-04	1.2e-02
8	NTR	Blood	0.0112	0.0066	1.7e-04	0.016	0.009	0.014	0.008	0.015	4.9e-06	5.5e-04	1.2e-05	8.7e-04	8.2e-06
9	YFS	Blood	0.1856	0.0513	0.0e+00	0.119	0.131	0.133	0.132	0.132	8.9e-37	1.1e-40	2.2e-41	6.4e-41	8.4e-41
10	TCGA	Lung Adenocarcinoma	0.0519	0.0423	2.3e-03	0.015	0.019	0.027	NA	0.016	6.9e-03	2.3e-03	3.3e-04	NA	5.2e-03
11	TCGA	Pheochromocytoma and Paraganglioma	0.2010	0.1660	6.2e-03	0.071	0.034	0.045	NA	0.047	8.7e-04	1.7e-02	6.8e-03	NA	6.2e-03
12	TCGA	Prostate Adenocarcinoma	0.0716	0.0504	8.2e-06	0.034	0.052	0.031	NA	0.042	1.5e-04	3.5e-06	2.9e-04	NA	3.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.5	2.3	5.8	1.3	2.4	-2.4	-0.7	-0.8	0.0	-0.0	1.6	1.4	-1.5	1.3	-2.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	0.6	1.5	-1.5	-0.8	-0.6	-0.5	-1.1	0.5	-0.0	-0.6	1.6	-1.4
Depressed Affect (Nagel 2018)	0.1	0.3	2.2	0.3	0.3	-0.4	-0.2	0.4	0.1	-1.5	0.1	-0.6	0.5	-0.0	-0.6
Depression (Nagel 2018)	1.0	1.5	11.3	0.9	-0.2	-0.5	-1.1	-0.3	-0.1	-3.4	-0.9	-1.8	0.2	0.4	0.0
Intelligence (Savage-Jansen 2018)	1.3	3.9	7.2	1.9	2.2	-2.1	1.1	1.0	2.1	2.1	2.6	2.7	-1.3	-1.4	-2.2
Neuroticism (Nagel 2018)	0.2	0.4	1.4	0.9	1.0	-0.9	-0.3	0.4	0.3	-1.2	0.3	-0.5	-0.1	-0.1	-0.6
Schizophrenia (2018)	0.3	0.5	2.1	-0.2	0.0	0.0	-0.4	-0.1	-0.6	-1.4	-0.6	-1.4	0.5	1.0	-0.0
Schizophrenia vs Biploar Disorder	1.4	1.9	4.7	-1.9	-2.1	2.2	0.1	-0.2	-1.1	0.1	-1.7	-1.1	1.2	0.2	1.8
Worry (Nagel 2018)	0.1	0.1	0.5	0.1	0.2	-0.1	-0.2	0.3	-0.2	-0.7	-0.3	-0.6	0.4	-0.2	-0.0
Alzheimer’s Disease (in mother)	1.1	1.3	4.2	-0.3	-0.2	-0.0	-0.8	-1.4	-1.2	-2.0	-1.1	-1.3	0.2	1.9	0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.5	0.4	0.2	-0.4	-0.2	0.1	0.3	-0.2	0.2	-0.0	-0.7	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.6	0.2	-0.3	-0.0	-0.5	-0.9	-0.2	-1.3	-0.7	-1.0	-0.3	1.1	0.6
Crohns Disease (2017)	0.4	0.9	1.8	-1.0	-0.8	0.7	-0.9	-0.4	-1.3	-1.3	-1.2	-1.3	0.9	0.6	0.9
Irritable Bowel Disease (IBD)	0.6	1.4	4.2	-1.2	-0.7	0.7	-1.1	-0.6	-1.5	-2.0	-1.2	-1.6	1.2	1.1	0.3
Ulcerative Colitis (UC)	0.8	1.5	4.0	-1.4	-0.6	0.7	-1.2	-0.8	-1.6	-2.0	-1.1	-1.5	1.1	1.6	-0.0
Major Depression (MDD)	0.7	0.8	2.4	1.6	1.2	-1.6	-0.2	-0.4	0.7	-0.9	0.4	0.1	-1.0	0.4	-0.5
Reaction Time	0.4	0.8	2.3	1.0	0.2	-0.4	-0.9	1.1	0.8	-1.5	0.6	-0.1	-0.4	-1.0	-1.1
Verbal and Numeric Reasoning (VNR)	4.1	9.9	16.8	3.2	3.8	-3.6	1.6	1.7	3.3	3.2	4.1	3.7	-2.1	-2.2	-3.9
Breast Cancer	0.2	0.5	2.4	-0.4	-1.5	1.2	-0.4	0.7	-0.0	-0.9	-0.2	-0.2	0.6	-0.9	-0.0
Ovarian Cancer	0.2	0.2	0.8	0.9	-0.0	-0.5	-0.5	-0.3	0.4	0.1	-0.1	0.1	-0.9	-0.2	0.4
Prostate Cancer	0.5	0.8	2.0	1.4	0.9	-1.1	0.5	1.0	1.1	0.2	0.8	0.8	-0.4	-0.9	-0.7
Age at First Birth	0.5	0.8	1.9	-0.2	1.1	-0.8	-0.9	-1.3	-0.7	0.3	0.5	0.7	-1.0	1.4	-0.9
Bipolar Disorder (2011)	2.3	2.2	4.5	1.6	2.1	-2.1	-0.7	-0.6	0.9	0.3	1.7	1.6	-1.9	0.1	-2.1
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	1.1	0.5	-0.9	1.1	0.6	0.9	-0.2	0.1	-0.0	-0.0	-0.8	0.1
Coronary Artery Disease (CAD)	0.6	0.7	2.4	-0.7	-0.1	-0.0	-0.7	-0.9	-1.0	-1.5	-0.6	-0.8	0.6	1.2	-0.1
Crohns Disease (2012)	0.2	0.4	1.0	-0.1	0.6	-0.5	-0.8	-0.7	-0.7	-1.0	0.2	-0.1	-0.2	0.9	-0.6
Mean Putamen Volume	0.9	1.1	2.8	-0.9	-0.8	0.7	-0.8	-1.6	-1.4	-0.2	-1.1	-0.4	-0.2	1.7	1.2
Fasting Glucose	0.1	0.1	1.0	0.3	0.1	-0.2	1.0	-0.1	0.5	-0.1	-0.2	-0.1	0.1	0.1	0.2
HbA1C	1.2	1.3	4.9	-0.3	-0.5	0.3	0.3	0.4	0.0	-2.2	-1.4	-2.1	1.8	0.8	0.7
HDL Cholesterol	0.2	0.4	1.5	-1.2	-0.7	0.8	-0.4	-0.1	-0.9	0.0	-0.4	-0.2	0.9	-0.1	0.1
LDL Cholesterol	1.3	2.1	4.6	-1.8	-1.6	1.3	-1.3	-1.7	-1.8	-0.2	-1.8	-0.8	0.1	1.0	2.2
Lupus	1.3	1.9	4.7	1.4	2.2	-1.9	-0.8	-0.9	0.5	0.2	1.6	1.1	-2.0	0.1	-1.9
Neuroticism (2016)	0.1	0.1	0.3	0.4	0.0	0.0	-0.2	-0.0	0.1	-0.3	-0.4	-0.5	0.3	-0.3	0.4
Primary Biliary Cirrhosis	0.2	0.3	1.7	0.6	0.4	-0.4	-0.7	0.1	-0.0	-1.3	-0.1	-0.7	-0.2	0.1	-0.3
Rheumatoid Arthritis	0.9	1.2	2.4	-1.0	-1.3	1.6	1.5	1.4	0.5	0.7	-0.3	-0.3	1.6	-1.1	0.6
Schizophrenia (2014)	0.0	0.1	0.3	-0.1	0.0	-0.0	-0.2	0.1	-0.2	-0.6	-0.1	-0.4	0.2	0.4	-0.4
Triglycerides	1.2	2.0	5.8	2.1	2.3	-2.4	-0.4	-0.1	1.0	-0.2	1.2	0.7	-1.7	-0.0	-1.6
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.5	0.6	0.7	-0.5	0.6	0.6	0.8	0.8	1.2	1.1	-0.6	-0.6	-1.0
Ulcerative Colitis	0.8	1.1	3.4	-0.4	0.1	-0.2	-1.8	-1.5	-1.4	-1.8	-0.4	-0.7	-0.0	1.4	-0.4
Blood Eosinophil Count	0.2	1.8	6.0	1.8	-0.7	-0.2	2.4	1.1	2.3	-0.8	-0.7	-0.4	0.7	-1.2	1.3
Blood Platelet Count	0.5	5.3	13.8	-1.6	-3.7	3.5	1.4	2.0	0.0	-0.6	-2.2	-1.7	2.8	-2.1	2.8
Blood Red Count	0.2	1.9	6.1	1.1	1.4	-1.0	0.0	-0.1	0.9	2.5	1.5	1.9	-2.2	-0.7	-0.9
Blood White Count	3.2	24.0	67.6	-2.5	-5.1	3.7	0.4	0.6	-2.4	-8.2	-6.6	-7.4	6.1	1.6	5.6
Heel T-Score	0.5	4.4	9.2	2.4	2.6	-2.4	1.3	2.5	2.3	0.7	2.5	1.4	-0.2	-1.7	-3.0
BMI	0.3	1.5	3.5	1.0	-0.1	-0.5	-1.1	-1.7	-0.6	-1.9	-1.5	-1.5	-1.0	0.9	1.5
Height	1.4	26.2	52.9	-6.2	-6.2	5.8	-2.9	-5.4	-5.7	-0.7	-6.5	-3.7	1.5	4.7	7.3
Waist Hip Ratio (WHR)	0.5	2.4	6.4	-0.6	-1.3	1.6	2.4	2.5	1.3	0.0	-0.6	-1.1	2.4	-1.7	0.6
Systolic Blood Pressure	0.2	1.1	2.7	-1.5	-1.6	1.5	-0.4	-0.7	-0.8	1.0	-1.0	0.3	0.3	0.0	1.6
Smoking Status	0.2	0.6	1.8	1.1	0.3	-0.4	0.8	1.3	1.1	0.3	-0.0	0.1	-0.1	-1.3	0.4
Allergy or Eczema	0.3	0.9	3.1	-0.9	-0.4	0.4	-0.8	0.2	-1.2	-1.8	-0.6	-1.1	1.3	0.8	-0.5
Cardiovascular Disease	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.3	0.2	-0.4	-0.4	-0.4	-0.3	0.0	-0.1	0.4
Hypothyroidism (self reported)	0.6	1.3	4.3	0.9	-0.4	-0.0	1.8	1.7	1.7	0.1	-0.4	-0.3	0.8	-2.1	0.9
Respiratory disease	0.1	0.2	1.0	0.6	-0.2	-0.2	0.1	-0.0	0.0	-1.0	-0.4	-0.2	0.4	-0.1	0.3
Type 2 Diabetes (T2D) (2018)	2.9	5.4	12.3	-1.8	-2.3	1.8	-1.4	-1.5	-2.3	-3.5	-3.1	-3.1	1.4	1.6	2.6
Lung FEV1/FVC ratio	0.7	3.3	7.0	-0.4	-1.5	0.9	-2.0	-2.2	-1.6	-2.2	-2.5	-2.2	-0.6	1.4	2.6
Lung FVC	1.6	8.0	19.1	2.1	4.4	-3.6	-0.8	-0.5	1.3	1.9	3.8	3.3	-3.0	0.7	-4.3
Neuroticism	0.2	0.4	1.0	0.7	0.7	-0.7	-1.0	-0.2	-0.1	-0.8	0.4	-0.3	-0.9	0.2	-0.8
Chronotype (morning person)	0.3	0.6	1.2	0.5	-0.4	-0.0	1.1	0.8	0.7	-0.7	-0.7	-1.1	0.8	-0.7	0.9
Hair Pigment	0.1	1.6	3.3	1.7	1.7	-1.8	-0.6	0.1	0.9	-0.2	1.5	1.4	-1.4	-0.3	-1.8
Tanning	0.2	2.2	4.4	1.6	2.1	-2.0	-0.2	-0.8	0.9	0.5	1.8	1.7	-1.4	0.7	-2.1
Hand grip strength (left)	0.4	1.2	5.5	-0.7	-0.3	0.2	-0.4	-2.3	-1.0	1.4	-0.4	0.8	-0.9	1.4	1.0
Number of treatments/medications taken	0.9	1.7	5.6	-0.5	-0.1	0.0	-2.3	-0.9	-1.6	-2.4	-1.3	-1.6	-0.0	0.9	0.7
Average weekly spirits intake	1.2	1.5	3.2	-1.2	-1.5	1.3	0.3	0.2	-0.7	-0.9	-1.7	-1.8	1.5	0.0	1.7
Sensitivity / hurt feelings	0.3	0.4	1.4	0.3	-0.2	-0.0	-1.2	-0.4	-0.4	-1.1	-0.7	-0.9	-0.6	-0.1	0.7
Frequency of depressed mood in last 2 weeks	0.8	1.1	8.2	0.9	-0.1	-0.6	-1.5	-0.4	-0.0	-2.9	-0.5	-1.1	-0.3	0.4	-0.4
Hearing difficulty/problems: Yes	2.5	3.8	9.3	2.9	2.8	-3.0	-1.1	-0.3	1.4	-0.0	1.9	1.3	-2.7	-0.2	-2.1
Relative age of first facial hair	0.6	1.3	3.1	-0.1	1.5	-1.2	-1.3	-1.0	-1.1	-1.3	0.6	-0.2	-0.2	1.5	-1.8
Other serious medical condition/disability diagnosed by doctor	2.8	3.7	6.3	2.4	2.5	-2.4	-0.3	0.8	1.7	0.9	2.3	2.0	-2.1	-1.5	-2.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.9	1.7	1.1	-1.5	-0.3	-0.1	1.3	-0.1	0.8	0.6	-1.5	-0.6	-0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	0.8	0.7	-0.6	-0.0	0.8	0.9	-0.0	1.0	0.4	-0.3	-0.7	-1.4
Systolic blood pressure, automated reading	0.2	0.6	2.0	-0.8	-0.6	0.5	-0.7	-1.4	-0.9	0.3	-0.7	0.5	-0.3	0.9	0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.5	-0.6	-0.9	0.8	0.3	-0.2	-0.5	-1.4	-1.4	-1.6	1.1	0.5	1.4
Angina	0.8	1.1	2.8	1.5	1.5	-1.7	-0.9	-0.7	0.3	-1.0	0.5	0.0	-1.4	0.5	-0.8
Medication for hormone replacement therapy	1.5	1.7	3.6	0.6	1.6	-1.6	-1.7	-1.9	-1.1	-0.3	0.2	0.5	-1.6	1.7	-0.5
Vitamin and mineral supplements	0.3	0.4	1.3	0.9	0.3	-0.7	1.1	0.4	0.8	-0.7	0.3	0.3	0.5	-0.2	-0.5
Supplements: Zinc	1.0	1.1	2.4	0.9	0.6	-0.8	0.1	0.5	1.1	1.3	1.4	1.6	-1.1	-1.0	-1.0
Medication: Co-codamol	2.1	2.5	4.8	2.2	1.9	-2.0	1.0	0.5	1.9	0.9	1.8	1.7	-1.4	-0.7	-1.6
Medication: Metformin	2.0	2.8	4.6	-1.6	-2.1	1.9	-1.3	-0.8	-1.8	-2.0	-2.1	-1.9	1.1	0.6	2.0
Diabetes (father)	0.4	0.5	1.4	-1.2	-0.6	0.9	0.1	-0.7	-0.9	-0.4	-0.7	-0.6	0.8	0.9	0.7
Diabetes (mother)	0.4	0.5	1.6	0.3	0.4	-0.4	0.7	0.8	0.6	1.0	0.4	0.9	0.2	-1.3	-0.1
Severe depression (siblings)	0.5	0.5	1.3	0.3	0.8	-0.7	-1.0	-0.7	-0.4	-1.0	0.5	-0.2	-0.5	0.7	-1.2
Pack years adult smoking proportion	0.5	0.7	2.5	0.8	1.6	-1.3	-0.1	0.0	0.1	-0.1	1.0	0.5	-0.6	0.3	-1.4
Impedance of leg (right)	0.6	2.8	4.7	-2.0	-2.1	2.0	-0.1	-0.2	-1.5	-1.5	-2.1	-2.0	1.6	0.8	2.2
Leg fat-free mass (left)	0.9	4.7	11.7	-1.7	-1.8	1.6	-2.1	-3.4	-2.6	-0.6	-2.8	-1.4	-0.5	2.2	3.1
Trunk fat percentage	1.2	4.9	9.6	-0.4	-1.2	0.5	-2.2	-2.6	-2.1	-3.1	-3.1	-2.9	-0.5	2.1	3.0
Hand grip strength (right)	0.3	0.8	4.2	-0.3	0.1	-0.2	-0.3	-2.1	-0.6	1.1	-0.1	0.6	-1.2	1.3	0.6
Townsend deprivation index at recruitment	0.4	0.5	2.9	0.8	-0.3	-0.1	0.3	0.6	0.7	-1.7	-0.4	-1.1	0.5	-0.5	0.2
Current tobacco smoking	0.2	0.4	1.7	0.1	-0.0	0.2	1.3	1.1	0.7	0.7	-0.1	0.1	0.5	-0.7	0.5
Average weekly fortified wine intake	1.6	1.8	4.0	1.7	1.3	-1.5	0.9	0.8	1.6	0.9	1.7	2.0	-1.0	-0.6	-1.5
Maternal smoking around birth	0.4	0.5	2.0	1.1	-0.1	-0.5	-0.0	0.1	0.2	-1.4	-0.9	-0.8	-0.2	-0.2	1.1
Fed-up feelings	0.2	0.4	1.7	0.3	0.3	-0.2	0.6	1.3	0.3	-0.9	0.2	-0.6	0.8	-1.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	8.7	1.0	-0.6	-0.0	-0.2	1.1	0.7	-3.0	-1.0	-2.0	0.9	-0.9	0.5
Relative age voice broke	0.3	0.4	1.3	0.5	0.8	-0.8	-1.2	-0.0	-0.1	-0.0	0.7	0.3	-0.6	-0.3	-1.0
Taking other prescription medications	0.8	1.2	7.4	0.0	0.5	-0.4	-0.2	1.2	-0.3	-2.7	-0.2	-1.4	1.6	-0.0	-0.8
Age when periods started (menarche)	0.1	0.2	0.7	-0.8	-0.2	0.5	-0.1	-0.3	-0.3	0.5	0.1	-0.0	0.1	0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.6	1.2	0.6	-1.0	-0.9	-0.6	0.5	-1.3	0.1	-0.9	-0.9	0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.1	0.9	-0.6	-0.2	0.3	0.1	0.8	0.7	0.5	-0.4	-0.0	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.4	-0.3	-0.5	0.4	-0.6	-0.2	-0.4	-0.6	-0.2	-0.4	0.2	-0.1	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.6	-0.8	-0.5	0.7	0.2	0.0	-0.3	0.2	-0.4	-0.5	0.4	-0.1	0.5
Serious illness, injury or assault to yourself	0.8	1.0	2.8	1.2	1.2	-1.3	-1.4	-0.6	0.2	-0.2	0.8	1.0	-1.7	-0.1	-0.8
High blood pressure	0.1	0.4	1.1	-0.6	-0.1	0.2	-0.9	-0.7	-1.1	-1.0	-0.6	-0.2	0.0	0.7	0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.0	-1.1	-1.0	1.0	0.1	0.5	-0.9	-1.3	-0.9	-1.1	1.7	0.5	0.1
Multivitamins +/- minerals	0.2	0.2	0.8	-0.1	0.2	0.0	-0.9	0.2	0.1	0.6	0.6	0.3	-0.6	-0.5	-0.6
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.3	-0.5	0.6	-0.5	-0.1	-0.2	0.3	-0.3	-0.2	-0.1	-0.1	0.4
Supplements: Glucosamine	0.9	1.1	3.0	-1.2	-0.3	0.6	-1.5	-1.7	-1.5	0.9	-0.6	-0.1	-0.7	1.5	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.5	0.2	0.3	-0.1	0.7	0.6	0.3	0.2	-0.0	0.1	0.5	-0.2	0.0
Medication: Atenolol	0.2	0.3	0.8	-0.3	0.1	0.0	-0.6	-0.4	-0.6	-0.9	-0.5	-0.7	0.1	0.8	0.2
Medication: Levothyroxine sodium	0.4	0.6	3.0	-0.2	-0.7	0.8	-0.2	0.7	0.4	1.2	-0.4	-0.1	-0.3	-1.7	0.9
Sitting height	0.5	3.5	10.6	-1.4	-1.2	1.0	-1.9	-3.3	-2.3	0.5	-2.1	-0.5	-0.9	2.4	2.6
Chronic bronchitis/emphysema (father)	1.1	1.3	3.0	1.2	1.0	-1.0	0.7	0.9	1.5	0.3	1.6	1.3	-0.3	-1.2	-1.7
High blood pressure (mother)	0.5	0.7	1.9	-1.4	-0.4	0.8	-0.9	-1.3	-1.2	0.8	-0.2	0.3	-0.3	1.0	0.3
Body mass index (BMI)	0.1	0.6	2.0	0.5	0.2	-0.4	-1.0	-1.4	-0.5	-0.7	-0.7	-0.5	-1.0	0.6	0.8
Impedance of leg (left)	0.5	2.3	4.9	-1.7	-2.2	2.1	0.7	0.9	-0.7	-0.7	-1.7	-1.6	1.7	-0.2	2.0
Leg predicted mass (left)	0.9	4.8	11.7	-1.7	-1.9	1.6	-2.0	-3.4	-2.6	-0.5	-2.8	-1.4	-0.5	2.2	3.2
Trunk fat mass	1.4	5.9	12.7	-1.2	-1.9	1.3	-2.2	-3.0	-2.5	-2.4	-3.5	-2.8	-0.3	2.3	3.6
Waist circumference	0.6	2.3	6.6	-1.1	-1.8	1.6	-0.3	-1.0	-1.2	-1.1	-2.4	-1.8	0.8	0.6	2.6
Number of incorrect matches in round	0.1	0.2	0.5	-0.2	0.2	-0.1	-0.7	-0.6	-0.3	-0.3	-0.3	-0.3	-0.5	0.7	0.3
Past tobacco smoking	0.5	0.9	2.6	-1.6	-1.0	1.2	0.2	-0.9	-1.1	0.2	-0.8	-0.5	0.7	1.3	0.9
Alcohol usually taken with meals	2.1	3.4	6.9	0.8	2.3	-1.9	-1.3	-1.2	0.1	1.6	2.4	2.4	-2.6	0.9	-2.6
Nervous feelings	0.2	0.3	1.0	0.8	1.0	-0.9	0.4	0.6	0.6	0.3	0.5	0.3	-0.2	-0.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.3	2.0	1.2	-1.7	-1.4	0.4	1.1	-2.1	0.3	-0.7	-1.1	-0.5	-0.9
Hearing difficulty/problems with background noise	1.6	2.6	8.9	3.0	2.4	-2.8	-0.3	0.6	1.6	-1.3	1.0	0.2	-1.3	-0.5	-1.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.0	-0.1	0.0	-0.2	-0.5	-0.1	-0.3	-0.0	-0.2	-0.4	0.5	-0.1
Had menopause	1.2	1.5	5.0	0.7	0.2	-0.3	1.8	2.2	1.6	-0.9	0.3	-0.7	1.7	-1.5	-0.6
Had other major operations	0.4	0.5	1.3	0.8	0.8	-0.9	-0.5	-0.5	0.2	-0.5	0.7	0.6	-0.6	0.8	-1.1
Forced vital capacity (FVC)	0.7	2.8	9.1	-1.5	-0.2	0.3	-1.8	-3.0	-2.5	-0.0	-1.2	-0.2	-0.7	2.9	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.4	0.6	1.2	-0.9	0.1	0.5	0.3	0.5	0.9	0.6	-0.3	-0.2	-0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	0.2	0.3	-0.3	-0.6	-0.2	-0.2	-0.7	0.0	-0.3	-0.3	0.6	-0.3
Qualifications: None of the above	2.2	4.7	10.1	-1.2	-2.7	2.6	1.8	2.2	0.3	-1.6	-2.2	-2.9	3.2	-1.4	2.3
Financial difficulties in last 2 years	1.0	1.3	5.9	2.4	1.6	-2.0	0.3	0.0	1.1	-0.7	0.2	0.3	-0.9	-0.1	-0.1
Mouth/teeth dental problems	2.1	3.2	6.0	-2.5	-2.2	2.2	-0.6	-0.7	-1.9	-1.4	-2.0	-2.2	2.0	0.9	1.5
Heart attack	0.5	0.7	1.4	1.1	0.9	-0.9	-1.2	-0.1	0.1	-1.2	0.2	-0.7	-1.1	-0.2	-0.6
Allergy	0.1	0.2	0.9	0.3	0.5	-0.4	-0.2	-0.7	0.2	0.5	0.1	0.2	-1.0	0.1	0.4
Pain all over the body in last month	0.5	0.5	1.6	-1.2	-1.0	1.2	-0.8	-0.4	-0.7	0.0	-0.5	-0.3	-0.0	0.3	0.5
Diabetes (self-reported)	0.9	1.4	5.6	-0.1	-1.5	0.9	-0.4	-0.3	-0.4	-2.4	-1.6	-1.8	0.7	-0.1	1.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.6	-0.1	0.2	-0.1	-0.2	-0.1	-0.2	-0.3	0.5	0.3	0.0	0.5	-0.8
Medication: Ramipril	2.9	3.8	13.3	-1.2	-1.1	0.8	-1.0	-0.9	-1.8	-3.6	-2.4	-3.1	1.6	1.8	1.6
Medication: Simvastatin	3.6	5.3	8.7	-2.4	-2.1	2.0	-1.5	-1.3	-2.9	-2.9	-2.7	-2.8	2.1	2.1	2.0
Fluid intelligence score	2.0	4.1	8.7	2.0	2.8	-2.7	-0.1	0.1	1.2	1.5	2.7	2.4	-2.0	-0.3	-3.0
Illnesses of siblings	0.3	0.4	0.8	0.6	-0.4	0.1	0.9	0.8	0.9	-0.6	-0.1	-0.9	0.5	-0.7	0.1
Neuroticism score	0.4	0.8	2.6	0.8	0.9	-1.0	-1.6	-0.9	-0.3	-0.9	0.3	0.0	-1.4	0.5	-0.5
Weight	1.0	5.0	11.8	-1.7	-2.0	1.7	-1.8	-3.1	-2.6	-1.1	-3.1	-2.0	-0.1	2.1	3.4
Impedance of arm (right)	0.9	4.4	12.5	-0.7	-0.7	0.1	-1.8	-2.0	-2.1	-3.5	-2.6	-3.0	0.3	2.7	2.0
Arm fat percentage (right)	0.7	2.7	5.8	0.2	-0.1	-0.3	-1.9	-2.4	-1.5	-2.3	-2.0	-1.9	-0.9	1.8	1.9
Trunk fat-free mass	0.7	4.1	7.6	-2.8	-2.4	2.6	-0.9	-2.5	-2.4	1.3	-2.2	-0.5	0.5	1.5	2.7
Hip circumference	0.9	3.8	8.9	-1.2	-1.5	1.1	-2.2	-3.0	-2.4	-1.3	-2.5	-1.4	-0.6	2.0	2.6
Time employed in main current job	1.9	2.2	5.3	-1.4	-2.1	2.3	1.1	2.0	0.5	0.2	-0.4	-0.9	2.1	-2.0	0.6
Alcohol intake versus 10 years previously	1.0	1.5	5.6	1.6	2.4	-2.1	1.0	0.6	1.2	0.1	1.1	0.2	-0.5	-0.1	-1.2
Father’s age at death	0.6	0.9	2.5	-0.2	-0.6	0.7	1.4	1.6	0.6	1.2	-0.0	0.3	1.1	-1.4	0.4
Worrier / anxious feelings	0.8	1.4	5.6	0.5	0.4	-0.7	-2.1	-1.4	-1.0	-2.4	-0.6	-1.0	-0.7	1.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.7	1.0	-0.6	-0.1	0.2	0.7	0.8	-1.6	-0.8	-0.8	0.3	-1.1	1.0
Falls in the last year	0.3	0.4	1.3	1.1	0.8	-0.9	0.5	0.4	0.9	-1.0	0.1	-0.1	0.1	-0.4	-0.3
Hair/balding pattern: Pattern 3	2.3	3.5	7.7	-2.8	-1.9	2.0	-0.5	-1.5	-2.4	-0.2	-2.3	-1.1	1.3	2.0	2.5
Number of live births	1.6	2.2	4.8	-0.7	-2.2	1.9	0.7	1.2	-0.1	-1.5	-1.6	-2.0	1.8	-0.7	1.8
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	15.1	-1.7	-0.3	0.3	-2.9	-3.9	-3.2	-0.8	-1.7	-0.7	-1.2	3.6	1.4
Pulse rate	2.4	4.0	10.3	-2.3	-3.2	3.0	0.9	0.2	-1.1	-1.1	-2.2	-1.9	2.4	0.0	2.4
Happiness	3.1	3.7	6.9	2.0	1.5	-1.5	0.2	1.9	2.3	1.4	2.6	2.2	-1.3	-2.4	-2.5
Noisy workplace	1.1	1.3	4.2	0.7	-0.5	0.3	1.9	2.0	1.6	0.1	0.0	-0.5	1.2	-1.7	0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.8	-0.0	1.3	-0.9	-1.2	-0.8	-0.3	0.9	1.7	1.8	-1.3	0.6	-2.2
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.2	8.1	2.8	2.2	-2.3	0.4	1.5	2.6	0.7	2.5	2.0	-1.5	-2.0	-2.5
Mouth/teeth dental problems: Dentures	4.7	7.9	12.0	3.2	3.4	-3.1	1.5	1.9	3.2	2.7	3.5	3.1	-2.4	-2.0	-3.0
Asthma	0.1	0.2	1.1	0.4	0.1	-0.2	-0.0	0.1	0.1	-1.1	0.2	-0.2	0.5	0.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.3	1.2	1.6	-1.8	-1.3	-0.9	-0.2	-0.6	0.5	0.4	-1.7	0.7	-0.7
Medication: Cholesterol lowering	0.2	0.3	1.5	0.4	0.3	-0.3	-1.0	0.2	-0.6	-1.2	0.0	-0.6	0.0	-0.1	-0.4
Depression (self-reported)	1.0	1.2	2.7	1.3	1.4	-1.3	1.1	1.6	1.1	0.4	1.1	0.8	0.2	-1.2	-1.1
Medication: Lansoprazole	0.9	1.0	2.1	-1.2	-1.1	1.4	0.2	0.9	-0.5	-0.7	-1.1	-1.5	1.3	0.0	1.0
Prospective memory result	1.7	2.1	4.2	0.2	-1.4	1.2	1.8	2.0	1.3	-0.4	-1.1	-1.5	1.3	-2.0	1.9
Lung cancer (father)	0.5	0.6	2.7	0.3	-0.2	0.1	-1.1	-1.0	-0.1	1.0	0.1	1.0	-1.7	0.1	0.3
Illnesses of mother	0.6	0.7	1.7	-0.6	-0.9	0.7	-0.2	-0.5	-0.7	-1.2	-1.0	-1.3	0.5	1.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.9	-0.5	0.2	-0.3	-1.6	-2.2	-1.5	-0.3	-0.7	-0.1	-1.2	1.9	0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	0.0	0.5	-0.4	-1.1	-1.2	-0.5	0.6	0.3	0.7	-1.2	0.5	-0.1
Impedance of arm (left)	0.7	3.3	11.9	-0.5	-0.8	0.1	-1.5	-1.4	-1.7	-3.5	-2.2	-2.6	0.3	2.2	1.7
Arm fat mass (right)	0.7	3.0	6.9	-0.4	-0.9	0.4	-1.7	-2.6	-1.8	-1.7	-2.4	-1.8	-0.6	1.8	2.5
Trunk predicted mass	0.7	4.0	7.6	-2.8	-2.4	2.6	-0.9	-2.4	-2.3	1.4	-2.2	-0.4	0.5	1.4	2.7
Standing height	1.5	15.2	30.7	-4.7	-4.5	4.3	-2.2	-4.1	-4.6	-0.6	-5.0	-2.9	1.4	3.6	5.5
Length of working week for main job	1.9	2.1	4.4	1.3	1.9	-1.9	-0.6	-0.9	0.6	0.9	1.8	2.1	-1.8	0.3	-1.8
Exposure to tobacco smoke at home	1.2	1.4	5.0	-0.8	-1.0	0.7	0.4	-0.0	-0.3	-2.2	-1.1	-1.9	1.8	1.0	0.4
Breastfed as a baby	2.1	2.6	5.2	1.7	1.3	-1.4	0.8	1.5	2.1	1.2	2.2	1.8	-0.8	-1.5	-2.3
Tense / ‘highly strung’	0.2	0.4	1.0	-0.0	0.3	-0.3	-0.9	-0.8	-0.7	-1.0	-0.3	-0.6	-0.2	1.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.7	0.4	-0.6	-0.1	0.9	0.5	-1.2	0.3	-0.1	-0.0	-0.0	-0.6
Hair/balding pattern: Pattern 4	3.8	9.1	19.5	3.8	2.0	-2.2	2.6	3.8	4.4	1.5	3.2	2.2	-0.6	-4.4	-2.8
Birth weight of first child	1.8	3.3	9.2	-1.4	-0.6	0.4	-2.0	-3.0	-2.7	-1.6	-1.7	-1.3	-0.1	3.0	1.1
Peak expiratory flow (PEF)	0.8	1.8	6.5	-0.3	0.5	-0.5	-2.5	-2.4	-1.4	0.3	0.2	0.7	-1.8	1.8	-0.3
Pulse wave reflection index	1.9	2.3	8.0	1.2	1.8	-1.8	-1.8	-2.0	-0.1	1.1	0.7	1.4	-2.8	1.2	-0.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.1	0.2	0.4	-0.6	-1.2	-1.7	-1.1	-1.5	-1.2	-0.9	-0.7	2.0	1.0
Loud music exposure frequency	0.4	0.5	1.6	0.9	-0.2	-0.1	-0.4	0.9	1.1	0.1	0.6	0.5	-0.5	-1.3	-0.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	6.0	0.4	1.7	-1.2	-0.3	-0.3	0.1	1.2	2.1	2.1	-1.2	0.4	-2.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.9	0.2	0.3	-0.6	-1.7	-2.2	-1.4	-1.4	-0.5	-0.0	-1.0	2.0	0.1
Blood clot in the leg (DVT)	2.2	2.9	7.7	0.8	-0.2	0.1	2.0	1.6	2.3	2.8	1.5	2.5	-0.1	-2.3	-0.6
Medication: Paracetamol	0.5	0.9	3.6	-0.4	0.1	-0.1	-1.1	-0.7	-1.4	-1.9	-0.9	-0.9	0.4	1.0	0.5
Headache pain in last month	0.5	0.9	2.6	0.9	1.0	-1.1	-0.8	-1.3	0.0	0.1	0.6	1.1	-1.6	0.7	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	2.6	-0.2	-0.3	0.3	1.6	0.3	0.7	0.6	0.1	0.4	0.7	-0.1	-0.0
Glaucoma (self-reported)	0.1	0.1	0.4	-0.3	-0.3	0.3	0.4	0.6	0.2	0.0	-0.0	0.1	0.6	-0.3	0.1
Gout (self-reported)	0.3	0.4	2.2	-0.2	0.4	-0.3	0.0	-0.2	-0.4	-1.5	-0.3	-0.7	0.9	0.8	-0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.9	0.5	-0.2	0.0	0.9	1.2	1.0	0.3	-0.3	-0.3	0.4	-1.7	0.6
Medication: Amlodipine	0.3	0.4	2.4	-0.3	-0.3	0.4	1.6	0.6	0.0	0.4	-0.1	0.0	0.9	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.7	-0.9	0.8	-0.1	-0.1	-0.5	-0.5	-0.4	-0.3	0.7	0.1	0.2
Birth weight	2.2	4.7	11.6	-1.7	-0.9	0.8	-2.4	-3.4	-3.0	-1.8	-2.2	-1.8	-0.4	3.3	1.8
Chronic bronchitis/emphysema (mother)	2.2	2.5	5.2	-1.2	-1.9	1.6	-1.1	-0.5	-1.6	-2.3	-2.1	-2.1	1.0	1.0	1.6
High blood pressure (siblings)	0.2	0.3	1.0	-0.9	-0.3	0.6	-0.3	-0.1	-0.5	1.0	-0.1	0.7	0.1	0.1	0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	3.7	-0.2	0.8	-0.8	-1.0	-1.9	-1.1	0.2	0.0	0.5	-1.1	1.9	-0.1
Body fat percentage	0.9	3.7	7.8	-0.5	-1.3	0.7	-1.9	-2.2	-1.8	-2.5	-2.8	-2.6	-0.4	1.6	2.8
Leg fat percentage (right)	0.5	1.9	4.5	-0.4	-1.2	0.8	-1.1	-1.2	-1.2	-1.9	-2.1	-2.0	0.1	0.7	2.1
Arm fat-free mass (right)	0.7	3.4	8.0	-2.3	-2.6	2.7	-0.6	-1.6	-1.8	1.0	-2.2	-0.6	0.6	0.7	2.8
Exposure to tobacco smoke outside home	0.8	1.0	2.3	-1.1	-1.2	1.3	-0.5	0.5	-0.6	-1.2	-1.1	-1.3	1.5	0.1	0.6
Comparative body size at age 10	0.6	1.7	4.5	-1.7	-1.8	2.1	1.4	1.3	-0.0	0.7	-0.7	-0.6	1.7	-0.9	1.0
Number of full brothers	1.3	1.7	3.5	1.0	1.9	-1.5	0.4	0.1	0.9	1.8	1.6	1.6	-1.2	0.0	-1.6
Worry too long after embarrassment	0.6	1.0	4.0	0.6	0.8	-0.9	-2.0	-1.4	-0.5	-0.1	0.1	0.3	-1.8	0.6	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.0	1.4	0.9	-1.4	-0.3	-0.1	0.5	-1.4	0.5	0.4	-0.4	0.2	-0.8
Wheeze or whistling in the chest in last year	0.6	1.0	3.1	1.3	0.4	-0.5	0.9	1.5	1.4	-0.1	0.8	0.3	0.1	-1.8	-0.8
Number of children fathered	0.9	1.0	2.9	0.7	1.4	-1.4	0.6	-0.4	0.4	0.1	1.3	1.1	-0.5	0.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.2	0.5	-0.4	-0.1	-0.0	0.6	0.4	-1.1	-0.2	-0.5	0.3	-0.4	0.1
Age at first live birth	0.8	1.4	2.5	1.1	1.2	-1.2	1.4	1.4	1.5	0.5	1.3	0.8	0.3	-0.8	-1.6
Pulse wave peak to peak time	0.4	0.5	1.4	-0.2	-0.6	0.5	1.0	1.1	0.3	-0.4	-0.4	-0.7	1.2	-0.5	0.3
Health satisfaction	1.1	1.4	4.2	-0.6	-1.4	1.0	-1.0	-0.5	-1.1	-2.0	-1.5	-1.5	0.4	0.4	1.4
Shortness of breath walking on level ground	2.0	2.3	6.1	-0.0	-1.6	0.9	-0.6	0.0	-0.7	-2.4	-2.3	-2.5	0.8	-0.2	2.4
Qualifications: College or University degree	0.9	2.9	6.5	1.4	2.0	-2.1	-1.2	-1.2	0.4	1.5	1.9	2.6	-2.3	0.6	-1.9
Eye problems/disorders: None of the above	1.0	1.2	3.7	0.4	0.5	-0.1	1.2	1.5	1.0	1.9	1.2	1.0	0.2	-1.3	-1.0
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.0	1.0	0.3	-0.3	0.5	1.1	1.4	2.0	1.4	1.7	-1.0	-1.8	-0.6
Emphysema/chronic bronchitis	0.9	1.0	2.4	-0.4	-1.2	1.1	0.5	0.9	0.0	-0.6	-1.2	-1.5	0.8	-1.0	1.5
Medication for pain relief, constipation, heartburn	0.6	1.1	8.1	-0.4	-0.5	0.7	1.0	-0.1	0.4	2.8	0.5	1.2	-0.5	-0.5	0.4
Neck or shoulder pain in last month	0.4	0.6	1.5	1.0	0.9	-1.1	-1.0	-1.0	0.2	-0.8	0.0	0.1	-1.2	0.5	-0.1
Medication: Blood pressure	0.5	0.9	4.0	-0.8	0.4	-0.0	-2.0	-1.1	-1.6	-0.4	-0.4	-0.5	-0.6	1.1	0.3
Angina (self-reported)	0.9	1.1	2.6	1.4	1.5	-1.6	-1.1	-0.8	0.2	-1.0	0.6	-0.0	-1.5	0.5	-0.9
Migraine (self-reported)	3.2	3.9	9.7	2.5	3.1	-3.0	0.0	-0.2	1.3	0.2	2.4	1.9	-1.9	0.2	-2.8
Medication: Ibuprofen	0.6	0.7	1.9	1.1	0.9	-1.4	-0.8	-0.6	-0.1	-1.4	0.1	-0.2	-0.8	0.6	-0.4
Medication: Allopurinol	0.6	0.7	2.3	-0.5	0.3	-0.1	-0.1	-0.8	-1.0	-1.5	-0.8	-1.0	0.8	1.5	0.3
Medication: Omeprazole	2.4	2.9	6.7	-1.9	-0.7	0.8	-1.3	-1.6	-2.4	-2.3	-1.6	-1.7	1.3	2.6	0.7
Medication: Seretide 50 evohaler	0.7	0.8	2.6	-0.9	-1.5	1.6	0.4	0.5	-0.2	0.2	-0.7	-0.7	0.8	-0.7	1.0
Mean time to correctly identify matches	0.6	1.2	4.5	1.0	-0.1	-0.0	-0.0	2.1	1.4	-1.4	0.7	-0.2	0.6	-1.8	-1.1
Heart disease (mother)	0.8	1.0	2.8	0.9	1.7	-1.3	0.4	0.8	0.8	0.8	1.3	0.9	-0.7	-0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.0	-0.4	0.6	-0.4	0.2	0.1	0.7	0.1	0.0	-0.3	-0.7	0.2
Whole body fat mass	1.3	5.2	11.8	-1.2	-1.8	1.3	-2.2	-3.0	-2.5	-2.0	-3.2	-2.5	-0.4	2.0	3.4
Leg fat mass (right)	0.9	3.3	8.9	-0.9	-1.7	1.3	-1.6	-2.2	-1.8	-1.5	-2.7	-2.0	-0.2	1.2	3.0
Arm predicted mass (right)	0.7	3.6	8.9	-2.4	-2.8	2.8	-0.6	-1.6	-1.8	0.9	-2.3	-0.7	0.6	0.7	3.0
Pulse rate, automated reading	1.0	3.2	6.6	-1.8	-2.6	2.4	-0.0	-0.4	-1.5	-1.4	-2.3	-2.1	1.5	0.2	2.5
Alcohol intake frequency.	1.1	2.5	5.2	2.1	2.3	-2.2	0.8	0.1	1.7	1.1	1.8	1.6	-1.7	-0.1	-1.4
Comparative height size at age 10	1.7	9.4	19.1	-4.1	-3.8	3.9	-1.0	-2.6	-3.5	0.1	-3.8	-2.2	1.7	2.3	4.4
Number of full sisters	0.3	0.4	1.4	0.1	0.3	-0.3	1.2	0.8	0.5	-0.8	-0.2	-0.6	1.0	-0.0	-0.0
Suffer from ‘nerves’	0.6	1.0	2.8	-0.8	-0.7	0.8	0.5	1.5	-0.0	-0.9	-0.9	-1.4	1.7	-0.9	0.8
Overall health rating	1.6	3.5	8.1	-1.1	-2.1	1.8	0.1	-0.1	-1.1	-2.8	-2.6	-2.8	1.7	0.5	2.6
Chest pain or discomfort	0.2	0.3	0.7	0.6	0.5	-0.6	-0.7	0.1	0.1	-0.3	0.6	0.8	-0.7	-0.3	-0.8
Had major operations	0.7	0.9	2.3	-0.0	-1.0	0.9	1.1	1.2	0.5	1.0	-0.8	-0.5	0.6	-1.2	1.5
Age at last live birth	0.8	1.1	2.8	1.6	0.9	-1.1	1.0	1.3	1.7	0.2	0.9	0.6	0.0	-1.1	-1.0
Family relationship satisfaction	1.1	1.4	3.3	1.8	1.2	-1.4	-0.2	0.8	1.4	-0.3	1.4	0.7	-1.0	-0.9	-1.6
Leg pain on walking	2.8	3.6	5.5	-2.3	-2.2	2.2	-0.5	-0.9	-2.2	-1.5	-2.3	-1.9	2.0	1.4	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	5.7	-2.4	-1.3	1.7	-0.8	-1.2	-2.1	-0.2	-1.5	-1.2	0.8	1.4	1.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	-1.0	-1.0	0.8	-0.7	-0.7	-0.9	-0.6	-0.8	-0.6	0.3	0.4	0.8
Illness, injury, bereavement, stress in last 2 years	5.0	6.1	12.0	-3.4	-3.5	3.4	0.0	-0.4	-2.1	-0.9	-2.9	-2.7	2.5	0.8	3.0
Medication: Aspirin	0.7	0.9	2.8	1.3	0.7	-0.8	0.1	1.2	1.1	-1.7	0.7	-0.3	0.2	-0.9	-1.3
Supplements: Vitamin C	1.3	1.5	4.3	-0.2	1.0	-0.8	-2.0	-1.8	-1.4	-0.4	0.2	0.3	-1.3	2.1	-0.8
Knee pain experienced in last month	1.8	2.8	6.1	-2.0	-1.3	1.4	-0.6	-1.9	-2.4	-1.3	-1.7	-1.2	1.4	2.5	1.3
Hypertension (Self-reported)	0.3	0.9	2.3	-1.2	-0.5	0.7	-1.1	-0.9	-1.5	-1.0	-1.0	-0.5	0.3	1.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.2	-1.2	-0.3	0.5	-0.5	-0.4	-1.2	-1.8	-0.7	-1.1	1.0	1.3	-0.0
Illnesses of father: Heart disease	0.6	0.9	2.8	0.8	1.0	-1.0	-0.4	0.4	0.7	-0.0	1.5	1.2	-0.7	-0.6	-1.7
Illnesses of siblings: Diabetes	0.3	0.3	0.8	-0.4	-0.4	0.3	0.5	-0.8	-0.4	-0.4	-0.8	-0.2	0.6	0.7	0.9
Smoking status: Previous	0.3	0.4	1.7	0.9	-0.4	-0.2	-0.1	0.7	0.7	-0.9	-0.2	-0.3	-0.0	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.9	-1.1	-1.4	1.2	-1.1	-1.7	-1.5	0.2	-1.6	-0.7	-0.5	0.9	2.2
Whole body fat-free mass	0.7	4.1	8.6	-2.3	-2.2	2.3	-1.3	-2.8	-2.4	0.6	-2.5	-0.8	0.1	1.7	2.9
Leg fat-free mass (right)	0.6	3.3	8.3	-1.4	-1.6	1.4	-1.6	-2.9	-2.1	-0.0	-2.3	-0.9	-0.5	1.8	2.8
Arm fat percentage (left)	0.6	2.4	5.5	0.2	-0.3	-0.2	-1.7	-2.1	-1.4	-2.3	-2.0	-1.9	-0.7	1.5	1.9
Average weekly red wine intake	0.3	0.4	1.3	0.5	-0.5	0.1	-0.4	-0.9	0.1	0.7	-0.4	0.7	-1.1	-0.2	1.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	-0.5	-0.4	0.6	0.9	0.7	0.0	0.8	0.2	0.2	1.0	-0.4	-0.2
Mood swings	0.8	1.5	6.3	-0.1	0.3	-0.5	-2.0	-1.5	-1.2	-2.5	-0.6	-1.1	-0.5	1.4	-0.2
Loneliness, isolation	0.9	1.2	2.3	1.5	1.4	-1.4	-0.3	0.8	1.2	0.3	1.3	0.7	-1.1	-1.0	-1.4
Long-standing illness, disability or infirmity	0.8	1.3	3.4	1.9	1.5	-1.5	-0.0	1.1	1.2	-0.9	0.9	0.0	-0.9	-1.2	-1.1
Ever had bowel cancer screening	1.1	1.3	3.1	-0.1	-1.0	0.9	1.7	1.8	1.2	-0.3	-0.3	-0.9	1.7	-1.5	0.3
Diabetes diagnosed by doctor	2.3	3.8	8.8	-1.2	-2.3	1.8	0.0	-0.3	-1.2	-3.0	-2.6	-2.9	2.0	0.5	2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	8.6	0.6	1.0	-1.1	-1.8	-2.1	-0.5	0.9	0.6	1.3	-2.9	1.3	-0.2
Friendships satisfaction	2.6	3.2	6.9	1.5	0.9	-0.8	2.1	2.6	2.4	1.2	2.0	1.5	0.4	-2.5	-1.8
Qualifications: nursing, teaching	3.4	5.3	10.4	2.7	2.8	-3.0	-1.1	-0.2	1.5	1.1	2.9	2.6	-3.0	-1.0	-3.2
Commuting to job workplace: Walk	0.6	0.6	1.7	0.8	1.3	-1.1	-0.8	-0.1	0.0	-0.1	0.6	0.4	-1.2	0.2	-1.0
Eye problems/disorders: Cataract	4.1	4.7	8.6	-2.0	-1.4	1.2	-2.6	-2.6	-2.9	-2.6	-2.4	-1.9	0.1	2.7	1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	0.3	-0.2	0.2	1.1	0.4	1.0	1.5	0.0	0.7	-0.3	-0.6	0.8
Medication for cholesterol	0.2	0.3	0.6	0.8	0.7	-0.7	0.1	0.2	0.6	0.7	0.8	0.4	-0.6	-0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	11.0	-0.1	-2.1	1.6	2.4	3.3	1.8	-1.2	-0.6	-1.2	3.3	-2.6	0.6
Back pain experienced in last month	0.4	0.6	2.9	0.7	0.6	-0.8	-0.9	-0.6	-0.4	-1.7	-0.5	-0.8	-0.2	0.6	0.3
Mineral and other dietary supplements	1.0	1.3	3.4	1.9	1.0	-1.3	1.2	1.0	1.7	0.2	1.0	0.9	-0.3	-1.2	-1.0
Breast cancer (self-reported)	0.1	0.1	0.4	-0.2	-0.2	0.2	0.5	0.1	0.4	0.6	0.5	0.5	0.1	-0.2	-0.4
Asthma (self-reported)	0.1	0.2	0.8	0.5	0.3	-0.4	-0.0	-0.0	0.1	-0.9	0.4	0.1	0.2	0.2	-0.8
Osteoporosis (self-reported)	0.4	0.5	2.4	0.7	0.8	-1.0	-0.4	-0.4	-0.2	-1.5	-0.2	-0.6	-0.5	0.6	-0.2
Osteoarthritis (self-reported)	0.8	1.1	2.9	-1.4	-0.7	0.8	-1.7	-1.2	-1.7	-0.7	-0.7	-0.1	0.2	1.3	0.5
Medication: Aspirin	0.8	1.1	2.5	1.5	0.5	-0.7	0.3	1.5	1.4	-1.6	0.6	-0.4	0.2	-1.2	-1.1
Medication: Gliclazide	0.8	0.9	2.0	-0.8	-1.3	1.0	-0.7	0.0	-0.7	-1.4	-1.1	-1.3	0.8	-0.5	0.8
Illnesses of father: None of the above (group 1)	2.3	2.8	5.5	-1.7	-2.2	2.1	-0.8	-1.4	-1.6	-0.6	-2.3	-1.9	0.5	1.2	2.3
Smoking status: Current	0.3	0.5	1.7	0.1	-0.0	0.3	1.3	1.2	0.7	0.8	-0.2	0.0	0.5	-0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.1	1.1	1.3	-1.5	-0.7	-0.7	0.1	-0.8	0.6	0.5	-1.2	0.6	-0.9
Whole body water mass	0.7	3.8	8.1	-2.3	-2.2	2.2	-1.2	-2.6	-2.3	0.7	-2.4	-0.7	0.2	1.6	2.9
Leg predicted mass (right)	0.6	3.4	8.4	-1.4	-1.6	1.4	-1.6	-2.9	-2.1	-0.1	-2.4	-1.0	-0.5	1.8	2.8
Arm fat mass (left)	0.7	2.8	6.3	-0.4	-0.8	0.4	-1.8	-2.5	-1.7	-1.8	-2.3	-1.8	-0.6	1.7	2.3
Number of self-reported non-cancer illnesses	0.7	1.3	2.3	1.5	1.1	-1.2	-0.9	1.2	1.0	-1.2	0.9	0.3	-0.5	-1.4	-1.5
Average weekly champagne plus white wine intake	1.6	2.2	5.9	1.0	1.9	-1.9	-1.5	-1.7	-0.3	0.9	1.0	1.4	-2.4	1.2	-1.1
Miserableness	0.5	0.9	2.6	1.4	1.0	-1.2	-1.1	-0.6	0.4	-0.1	0.8	1.0	-1.6	-0.1	-0.8
Guilty feelings	2.5	3.7	7.3	2.3	2.6	-2.6	-0.7	-0.0	1.1	0.6	2.5	2.1	-2.3	-0.3	-2.7
Wears glasses or contact lenses	1.7	1.9	4.2	1.7	1.8	-2.1	-1.3	-1.2	0.4	-0.9	1.1	0.7	-1.8	0.9	-1.8
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.6	-0.4	0.2	-0.1	-0.7	-0.9	-0.6	-0.9	-0.6	0.3	0.9	0.9
Hearing aid user	0.8	0.9	2.6	0.4	-0.7	0.4	1.6	1.6	1.0	-0.6	-0.2	-0.6	1.2	-1.3	0.3
Mother’s age at death	2.2	2.8	4.8	1.6	1.8	-1.8	0.5	0.3	1.6	1.8	2.2	2.2	-1.9	-0.7	-2.0
Financial situation satisfaction	1.6	2.0	6.4	0.2	-0.8	0.6	1.6	2.5	1.0	-1.6	-0.6	-1.7	2.2	-1.5	0.4
Tinnitus: Yes, now most or all of the time	4.2	4.9	12.3	2.8	1.6	-1.8	3.0	2.8	3.5	1.3	1.9	1.3	-0.0	-2.5	-1.6
Commuting to job workplace: Public transport	2.9	3.5	6.3	2.2	2.3	-2.1	-0.4	1.0	1.6	1.3	2.4	2.2	-2.0	-1.2	-2.5
Eye problems/disorders: Glaucoma	0.7	0.8	2.1	-1.1	-1.4	1.3	1.0	0.5	-0.1	-0.0	-0.7	-0.5	1.5	0.0	0.8
Medication: Blood pressure	0.8	1.6	3.6	-1.0	-1.4	1.2	-1.1	-0.9	-1.2	-1.9	-1.7	-1.4	0.6	0.6	1.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.1	1.4	1.4	-1.4	0.8	0.6	0.7	-0.4	0.5	0.1	-0.1	0.1	-0.6
Supplements: Fish oil (including cod liver oil)	1.0	1.4	3.4	-1.9	-1.0	1.3	-1.5	-1.0	-1.6	-0.6	-1.0	-0.9	0.3	1.3	0.7
High cholesterol (Self-reported)	0.3	0.5	2.1	0.5	0.6	-0.6	-0.0	0.8	-0.1	-1.4	-0.0	-0.7	1.0	-0.1	-0.5
Medication: Bendroflumethiazide	0.9	1.4	4.6	-0.8	-0.9	0.6	-2.2	-1.0	-1.6	-2.0	-1.1	-0.7	0.1	0.8	0.6
Medication: Paracetamol	1.2	1.8	4.0	-1.1	-0.7	0.6	-1.3	-1.2	-1.9	-2.0	-1.7	-1.3	0.7	1.3	1.4
Medication: Lisinopril	1.1	1.4	5.0	0.9	1.1	-1.2	-1.6	-0.8	0.1	0.8	1.3	1.5	-2.2	-0.2	-1.1
Medication: Atorvastatin	0.7	0.8	3.2	1.4	0.2	-0.4	0.3	1.5	1.2	-0.1	0.5	0.2	-0.5	-1.8	-0.3
Illnesses of father: High blood pressure	1.0	1.3	2.2	-1.4	-1.1	1.0	-0.2	-0.8	-1.4	-0.8	-1.5	-1.0	0.9	1.3	1.4
Alcohol drinker status: Never	1.0	1.2	3.6	1.1	0.2	-0.3	1.9	1.9	1.7	0.5	0.1	-0.0	0.5	-1.6	0.6
Ever smoked	1.7	3.0	6.6	2.0	2.4	-2.1	-0.3	0.9	1.3	0.8	2.2	2.0	-1.4	-1.1	-2.6
Basal metabolic rate	0.9	4.8	11.0	-2.3	-2.4	2.3	-1.4	-2.9	-2.6	0.1	-2.8	-1.3	0.2	1.9	3.3
Leg fat percentage (left)	0.3	1.2	3.3	-0.2	-1.1	0.7	-0.6	-0.5	-0.6	-1.5	-1.7	-1.7	0.2	0.1	1.8
Arm fat-free mass (left)	0.7	3.4	8.5	-2.2	-2.3	2.3	-0.8	-2.0	-1.9	0.7	-2.4	-0.9	0.4	1.1	2.9
Number of operations (self-reported)	0.5	0.7	2.2	1.5	0.8	-1.1	0.0	0.2	1.2	0.7	0.6	0.8	-1.2	-0.5	-0.2
Average weekly beer plus cider intake	0.5	0.7	1.2	0.6	0.8	-0.9	-0.7	-1.0	-0.7	-1.1	-0.7	-0.7	-0.6	1.1	0.6
Irritability	0.5	0.8	2.4	1.0	1.5	-1.5	-0.7	-0.8	-0.1	-0.4	0.5	0.6	-1.1	0.5	-0.5
Risk taking	0.9	1.3	5.0	0.1	0.6	-0.8	-1.7	-2.2	-1.2	-1.0	0.0	0.3	-1.2	1.6	-0.4
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.2	0.6	1.0	-0.8	-1.0	-0.2	0.5	1.1	1.2	1.3	-1.5	-0.4	-1.2
Fractured/broken bones in last 5 years	0.7	0.9	2.0	1.2	1.4	-1.3	1.3	0.7	1.0	0.4	0.9	0.8	0.1	0.1	-1.0
Age started oral contraceptive pill	0.5	0.6	1.6	0.5	0.4	-0.3	0.7	1.3	0.7	-0.5	0.8	0.3	0.5	-1.1	-1.2
Diastolic blood pressure, automated reading	1.2	3.9	9.0	-1.7	-2.2	1.8	-1.8	-2.5	-2.3	-0.9	-2.6	-1.4	-0.3	1.6	3.0
Ever depressed for a whole week	0.1	0.1	0.9	0.4	-0.2	-0.0	-0.6	-0.1	-0.1	-0.9	-0.0	-0.1	-0.2	0.2	-0.2
Unable to work because of sickness or disability	0.7	0.9	3.2	-0.2	-1.2	1.2	0.7	1.5	0.9	-0.1	-0.2	-0.4	0.7	-1.8	0.5
Commuting to job workplace: Cycle	0.3	0.3	1.2	0.7	0.5	-0.8	1.1	0.4	1.0	0.1	0.2	0.3	0.3	-0.2	0.0
Myopia	0.5	0.7	2.9	-0.6	-0.3	0.3	0.3	0.5	-0.1	-1.5	-0.5	-1.2	1.7	0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.9	-0.2	-0.5	0.4	1.0	0.3	0.5	0.8	0.1	0.0	0.6	-0.1	-0.1
Cholesterol lowering medication	1.5	2.3	5.2	-1.6	-2.0	1.8	0.9	0.5	-0.6	-1.2	-1.9	-1.6	2.3	0.1	1.8
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	8.2	-2.2	-0.6	0.9	-1.3	-1.8	-2.7	-2.0	-1.6	-1.4	1.4	2.9	0.6
Pain experienced in last month	0.4	0.6	1.8	-0.4	-0.7	0.7	1.0	1.3	0.5	0.3	0.3	-0.2	1.1	-1.3	-0.4
Supplements: Calcium	0.3	0.4	1.3	0.1	-0.1	-0.2	-1.2	-0.9	-0.6	-0.8	-0.4	-0.4	-0.7	0.5	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	-0.3	-0.7	0.6	1.1	0.2	0.2	0.3	-0.5	-0.3	0.6	-0.0	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	1.3	1.1	-1.1	-1.1	-0.2	0.1	-1.2	0.3	-0.5	-1.1	-0.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	7.0	0.7	-0.1	0.1	2.0	1.4	2.2	2.6	1.4	2.4	-0.2	-2.0	-0.6
Heart disease (siblings)	0.2	0.3	0.8	-0.6	0.4	-0.0	0.4	0.4	-0.1	0.3	0.7	0.8	0.5	0.4	-0.9
Alcohol drinker status: Previous	0.8	0.9	2.0	0.7	1.0	-1.0	-0.8	-0.8	-0.0	0.6	1.1	1.4	-1.4	0.4	-1.1
Pack years of smoking	0.6	0.9	2.9	1.0	1.7	-1.4	0.0	0.4	0.4	-0.1	1.2	0.5	-0.6	-0.1	-1.6
Impedance of whole body	0.5	2.6	6.3	-1.0	-1.5	1.0	-0.7	-0.5	-1.3	-2.5	-2.3	-2.5	0.9	1.3	2.1
Leg fat mass (left)	0.8	3.2	8.6	-1.0	-1.8	1.4	-1.5	-2.0	-1.8	-1.4	-2.6	-2.0	-0.1	1.0	2.9
Arm predicted mass (left)	0.8	4.1	9.7	-2.4	-2.5	2.6	-1.0	-2.3	-2.1	0.8	-2.5	-0.9	0.3	1.2	3.1