Hub : Genes

TPST1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0380 0.0230 9.1e-04 0.027 NA 0.025 NA 0.028 2.7e-03 NA 3.7e-03 NA 2.4e-03
2 GTEx Colon Sigmoid 0.0530 0.0340 7.2e-03 0.033 NA 0.044 NA 0.054 2.5e-02 NA 1.2e-02 NA 5.6e-03
3 GTEx Esophagus Mucosa 0.0660 0.0330 1.3e-05 0.070 NA 0.088 NA 0.084 2.0e-05 NA 1.7e-06 NA 3.0e-06
4 GTEx Heart Left Ventricle 0.0877 0.0562 6.5e-03 0.100 NA 0.062 NA 0.082 5.7e-06 NA 3.2e-04 NA 4.0e-05
5 GTEx Lung 0.0961 0.0467 3.4e-04 0.050 NA 0.058 NA 0.056 1.0e-04 NA 2.9e-05 NA 4.0e-05
6 GTEx Thyroid 0.0650 0.0330 9.6e-05 0.019 NA 0.056 NA 0.036 1.3e-02 NA 4.3e-05 NA 9.1e-04
7 METSIM Adipose 0.0476 0.0361 4.8e-03 0.006 0.022 0.017 0.023 0.009 3.7e-02 2.6e-04 9.8e-04 1.7e-04 1.2e-02
8 NTR Blood 0.0112 0.0066 1.7e-04 0.016 0.009 0.014 0.008 0.015 4.9e-06 5.5e-04 1.2e-05 8.7e-04 8.2e-06
9 YFS Blood 0.1856 0.0513 0.0e+00 0.119 0.131 0.133 0.132 0.132 8.9e-37 1.1e-40 2.2e-41 6.4e-41 8.4e-41
10 TCGA Lung Adenocarcinoma 0.0519 0.0423 2.3e-03 0.015 0.019 0.027 NA 0.016 6.9e-03 2.3e-03 3.3e-04 NA 5.2e-03
11 TCGA Pheochromocytoma and Paraganglioma 0.2010 0.1660 6.2e-03 0.071 0.034 0.045 NA 0.047 8.7e-04 1.7e-02 6.8e-03 NA 6.2e-03
12 TCGA Prostate Adenocarcinoma 0.0716 0.0504 8.2e-06 0.034 0.052 0.031 NA 0.042 1.5e-04 3.5e-06 2.9e-04 NA 3.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.5 2.3 5.8 1.3 2.4 -2.4 -0.7 -0.8 0.0 -0.0 1.6 1.4 -1.5 1.3 -2.2
Bipolar Disorder or Schizophrenia 0.4 1.0 2.6 0.6 1.5 -1.5 -0.8 -0.6 -0.5 -1.1 0.5 -0.0 -0.6 1.6 -1.4
Depressed Affect (Nagel 2018) 0.1 0.3 2.2 0.3 0.3 -0.4 -0.2 0.4 0.1 -1.5 0.1 -0.6 0.5 -0.0 -0.6
Depression (Nagel 2018) 1.0 1.5 11.3 0.9 -0.2 -0.5 -1.1 -0.3 -0.1 -3.4 -0.9 -1.8 0.2 0.4 0.0
Intelligence (Savage-Jansen 2018) 1.3 3.9 7.2 1.9 2.2 -2.1 1.1 1.0 2.1 2.1 2.6 2.7 -1.3 -1.4 -2.2
Neuroticism (Nagel 2018) 0.2 0.4 1.4 0.9 1.0 -0.9 -0.3 0.4 0.3 -1.2 0.3 -0.5 -0.1 -0.1 -0.6
Schizophrenia (2018) 0.3 0.5 2.1 -0.2 0.0 0.0 -0.4 -0.1 -0.6 -1.4 -0.6 -1.4 0.5 1.0 -0.0
Schizophrenia vs Biploar Disorder 1.4 1.9 4.7 -1.9 -2.1 2.2 0.1 -0.2 -1.1 0.1 -1.7 -1.1 1.2 0.2 1.8
Worry (Nagel 2018) 0.1 0.1 0.5 0.1 0.2 -0.1 -0.2 0.3 -0.2 -0.7 -0.3 -0.6 0.4 -0.2 -0.0
Alzheimer’s Disease (in mother) 1.1 1.3 4.2 -0.3 -0.2 -0.0 -0.8 -1.4 -1.2 -2.0 -1.1 -1.3 0.2 1.9 0.7
Alzheimer’s Disease (in father) 0.1 0.1 0.5 0.4 0.2 -0.4 -0.2 0.1 0.3 -0.2 0.2 -0.0 -0.7 0.1 -0.2
Alzheimer’s Disease (including proxy) 0.3 0.5 1.6 0.2 -0.3 -0.0 -0.5 -0.9 -0.2 -1.3 -0.7 -1.0 -0.3 1.1 0.6
Crohns Disease (2017) 0.4 0.9 1.8 -1.0 -0.8 0.7 -0.9 -0.4 -1.3 -1.3 -1.2 -1.3 0.9 0.6 0.9
Irritable Bowel Disease (IBD) 0.6 1.4 4.2 -1.2 -0.7 0.7 -1.1 -0.6 -1.5 -2.0 -1.2 -1.6 1.2 1.1 0.3
Ulcerative Colitis (UC) 0.8 1.5 4.0 -1.4 -0.6 0.7 -1.2 -0.8 -1.6 -2.0 -1.1 -1.5 1.1 1.6 -0.0
Major Depression (MDD) 0.7 0.8 2.4 1.6 1.2 -1.6 -0.2 -0.4 0.7 -0.9 0.4 0.1 -1.0 0.4 -0.5
Reaction Time 0.4 0.8 2.3 1.0 0.2 -0.4 -0.9 1.1 0.8 -1.5 0.6 -0.1 -0.4 -1.0 -1.1
Verbal and Numeric Reasoning (VNR) 4.1 9.9 16.8 3.2 3.8 -3.6 1.6 1.7 3.3 3.2 4.1 3.7 -2.1 -2.2 -3.9
Breast Cancer 0.2 0.5 2.4 -0.4 -1.5 1.2 -0.4 0.7 -0.0 -0.9 -0.2 -0.2 0.6 -0.9 -0.0
Ovarian Cancer 0.2 0.2 0.8 0.9 -0.0 -0.5 -0.5 -0.3 0.4 0.1 -0.1 0.1 -0.9 -0.2 0.4
Prostate Cancer 0.5 0.8 2.0 1.4 0.9 -1.1 0.5 1.0 1.1 0.2 0.8 0.8 -0.4 -0.9 -0.7
Age at First Birth 0.5 0.8 1.9 -0.2 1.1 -0.8 -0.9 -1.3 -0.7 0.3 0.5 0.7 -1.0 1.4 -0.9
Bipolar Disorder (2011) 2.3 2.2 4.5 1.6 2.1 -2.1 -0.7 -0.6 0.9 0.3 1.7 1.6 -1.9 0.1 -2.1
Body Mass Index (BMI) (2010) 0.3 0.5 1.3 1.1 0.5 -0.9 1.1 0.6 0.9 -0.2 0.1 -0.0 -0.0 -0.8 0.1
Coronary Artery Disease (CAD) 0.6 0.7 2.4 -0.7 -0.1 -0.0 -0.7 -0.9 -1.0 -1.5 -0.6 -0.8 0.6 1.2 -0.1
Crohns Disease (2012) 0.2 0.4 1.0 -0.1 0.6 -0.5 -0.8 -0.7 -0.7 -1.0 0.2 -0.1 -0.2 0.9 -0.6
Mean Putamen Volume 0.9 1.1 2.8 -0.9 -0.8 0.7 -0.8 -1.6 -1.4 -0.2 -1.1 -0.4 -0.2 1.7 1.2
Fasting Glucose 0.1 0.1 1.0 0.3 0.1 -0.2 1.0 -0.1 0.5 -0.1 -0.2 -0.1 0.1 0.1 0.2
HbA1C 1.2 1.3 4.9 -0.3 -0.5 0.3 0.3 0.4 0.0 -2.2 -1.4 -2.1 1.8 0.8 0.7
HDL Cholesterol 0.2 0.4 1.5 -1.2 -0.7 0.8 -0.4 -0.1 -0.9 0.0 -0.4 -0.2 0.9 -0.1 0.1
LDL Cholesterol 1.3 2.1 4.6 -1.8 -1.6 1.3 -1.3 -1.7 -1.8 -0.2 -1.8 -0.8 0.1 1.0 2.2
Lupus 1.3 1.9 4.7 1.4 2.2 -1.9 -0.8 -0.9 0.5 0.2 1.6 1.1 -2.0 0.1 -1.9
Neuroticism (2016) 0.1 0.1 0.3 0.4 0.0 0.0 -0.2 -0.0 0.1 -0.3 -0.4 -0.5 0.3 -0.3 0.4
Primary Biliary Cirrhosis 0.2 0.3 1.7 0.6 0.4 -0.4 -0.7 0.1 -0.0 -1.3 -0.1 -0.7 -0.2 0.1 -0.3
Rheumatoid Arthritis 0.9 1.2 2.4 -1.0 -1.3 1.6 1.5 1.4 0.5 0.7 -0.3 -0.3 1.6 -1.1 0.6
Schizophrenia (2014) 0.0 0.1 0.3 -0.1 0.0 -0.0 -0.2 0.1 -0.2 -0.6 -0.1 -0.4 0.2 0.4 -0.4
Triglycerides 1.2 2.0 5.8 2.1 2.3 -2.4 -0.4 -0.1 1.0 -0.2 1.2 0.7 -1.7 -0.0 -1.6
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.5 0.6 0.7 -0.5 0.6 0.6 0.8 0.8 1.2 1.1 -0.6 -0.6 -1.0
Ulcerative Colitis 0.8 1.1 3.4 -0.4 0.1 -0.2 -1.8 -1.5 -1.4 -1.8 -0.4 -0.7 -0.0 1.4 -0.4
Blood Eosinophil Count 0.2 1.8 6.0 1.8 -0.7 -0.2 2.4 1.1 2.3 -0.8 -0.7 -0.4 0.7 -1.2 1.3
Blood Platelet Count 0.5 5.3 13.8 -1.6 -3.7 3.5 1.4 2.0 0.0 -0.6 -2.2 -1.7 2.8 -2.1 2.8
Blood Red Count 0.2 1.9 6.1 1.1 1.4 -1.0 0.0 -0.1 0.9 2.5 1.5 1.9 -2.2 -0.7 -0.9
Blood White Count 3.2 24.0 67.6 -2.5 -5.1 3.7 0.4 0.6 -2.4 -8.2 -6.6 -7.4 6.1 1.6 5.6
Heel T-Score 0.5 4.4 9.2 2.4 2.6 -2.4 1.3 2.5 2.3 0.7 2.5 1.4 -0.2 -1.7 -3.0
BMI 0.3 1.5 3.5 1.0 -0.1 -0.5 -1.1 -1.7 -0.6 -1.9 -1.5 -1.5 -1.0 0.9 1.5
Height 1.4 26.2 52.9 -6.2 -6.2 5.8 -2.9 -5.4 -5.7 -0.7 -6.5 -3.7 1.5 4.7 7.3
Waist Hip Ratio (WHR) 0.5 2.4 6.4 -0.6 -1.3 1.6 2.4 2.5 1.3 0.0 -0.6 -1.1 2.4 -1.7 0.6
Systolic Blood Pressure 0.2 1.1 2.7 -1.5 -1.6 1.5 -0.4 -0.7 -0.8 1.0 -1.0 0.3 0.3 0.0 1.6
Smoking Status 0.2 0.6 1.8 1.1 0.3 -0.4 0.8 1.3 1.1 0.3 -0.0 0.1 -0.1 -1.3 0.4
Allergy or Eczema 0.3 0.9 3.1 -0.9 -0.4 0.4 -0.8 0.2 -1.2 -1.8 -0.6 -1.1 1.3 0.8 -0.5
Cardiovascular Disease 0.0 0.1 0.2 -0.1 -0.1 0.2 -0.3 0.2 -0.4 -0.4 -0.4 -0.3 0.0 -0.1 0.4
Hypothyroidism (self reported) 0.6 1.3 4.3 0.9 -0.4 -0.0 1.8 1.7 1.7 0.1 -0.4 -0.3 0.8 -2.1 0.9
Respiratory disease 0.1 0.2 1.0 0.6 -0.2 -0.2 0.1 -0.0 0.0 -1.0 -0.4 -0.2 0.4 -0.1 0.3
Type 2 Diabetes (T2D) (2018) 2.9 5.4 12.3 -1.8 -2.3 1.8 -1.4 -1.5 -2.3 -3.5 -3.1 -3.1 1.4 1.6 2.6
Lung FEV1/FVC ratio 0.7 3.3 7.0 -0.4 -1.5 0.9 -2.0 -2.2 -1.6 -2.2 -2.5 -2.2 -0.6 1.4 2.6
Lung FVC 1.6 8.0 19.1 2.1 4.4 -3.6 -0.8 -0.5 1.3 1.9 3.8 3.3 -3.0 0.7 -4.3
Neuroticism 0.2 0.4 1.0 0.7 0.7 -0.7 -1.0 -0.2 -0.1 -0.8 0.4 -0.3 -0.9 0.2 -0.8
Chronotype (morning person) 0.3 0.6 1.2 0.5 -0.4 -0.0 1.1 0.8 0.7 -0.7 -0.7 -1.1 0.8 -0.7 0.9
Hair Pigment 0.1 1.6 3.3 1.7 1.7 -1.8 -0.6 0.1 0.9 -0.2 1.5 1.4 -1.4 -0.3 -1.8
Tanning 0.2 2.2 4.4 1.6 2.1 -2.0 -0.2 -0.8 0.9 0.5 1.8 1.7 -1.4 0.7 -2.1
Hand grip strength (left) 0.4 1.2 5.5 -0.7 -0.3 0.2 -0.4 -2.3 -1.0 1.4 -0.4 0.8 -0.9 1.4 1.0
Number of treatments/medications taken 0.9 1.7 5.6 -0.5 -0.1 0.0 -2.3 -0.9 -1.6 -2.4 -1.3 -1.6 -0.0 0.9 0.7
Average weekly spirits intake 1.2 1.5 3.2 -1.2 -1.5 1.3 0.3 0.2 -0.7 -0.9 -1.7 -1.8 1.5 0.0 1.7
Sensitivity / hurt feelings 0.3 0.4 1.4 0.3 -0.2 -0.0 -1.2 -0.4 -0.4 -1.1 -0.7 -0.9 -0.6 -0.1 0.7
Frequency of depressed mood in last 2 weeks 0.8 1.1 8.2 0.9 -0.1 -0.6 -1.5 -0.4 -0.0 -2.9 -0.5 -1.1 -0.3 0.4 -0.4
Hearing difficulty/problems: Yes 2.5 3.8 9.3 2.9 2.8 -3.0 -1.1 -0.3 1.4 -0.0 1.9 1.3 -2.7 -0.2 -2.1
Relative age of first facial hair 0.6 1.3 3.1 -0.1 1.5 -1.2 -1.3 -1.0 -1.1 -1.3 0.6 -0.2 -0.2 1.5 -1.8
Other serious medical condition/disability diagnosed by doctor 2.8 3.7 6.3 2.4 2.5 -2.4 -0.3 0.8 1.7 0.9 2.3 2.0 -2.1 -1.5 -2.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.9 1.7 1.1 -1.5 -0.3 -0.1 1.3 -0.1 0.8 0.6 -1.5 -0.6 -0.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.8 0.8 0.7 -0.6 -0.0 0.8 0.9 -0.0 1.0 0.4 -0.3 -0.7 -1.4
Systolic blood pressure, automated reading 0.2 0.6 2.0 -0.8 -0.6 0.5 -0.7 -1.4 -0.9 0.3 -0.7 0.5 -0.3 0.9 0.9
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.5 -0.6 -0.9 0.8 0.3 -0.2 -0.5 -1.4 -1.4 -1.6 1.1 0.5 1.4
Angina 0.8 1.1 2.8 1.5 1.5 -1.7 -0.9 -0.7 0.3 -1.0 0.5 0.0 -1.4 0.5 -0.8
Medication for hormone replacement therapy 1.5 1.7 3.6 0.6 1.6 -1.6 -1.7 -1.9 -1.1 -0.3 0.2 0.5 -1.6 1.7 -0.5
Vitamin and mineral supplements 0.3 0.4 1.3 0.9 0.3 -0.7 1.1 0.4 0.8 -0.7 0.3 0.3 0.5 -0.2 -0.5
Supplements: Zinc 1.0 1.1 2.4 0.9 0.6 -0.8 0.1 0.5 1.1 1.3 1.4 1.6 -1.1 -1.0 -1.0
Medication: Co-codamol 2.1 2.5 4.8 2.2 1.9 -2.0 1.0 0.5 1.9 0.9 1.8 1.7 -1.4 -0.7 -1.6
Medication: Metformin 2.0 2.8 4.6 -1.6 -2.1 1.9 -1.3 -0.8 -1.8 -2.0 -2.1 -1.9 1.1 0.6 2.0
Diabetes (father) 0.4 0.5 1.4 -1.2 -0.6 0.9 0.1 -0.7 -0.9 -0.4 -0.7 -0.6 0.8 0.9 0.7
Diabetes (mother) 0.4 0.5 1.6 0.3 0.4 -0.4 0.7 0.8 0.6 1.0 0.4 0.9 0.2 -1.3 -0.1
Severe depression (siblings) 0.5 0.5 1.3 0.3 0.8 -0.7 -1.0 -0.7 -0.4 -1.0 0.5 -0.2 -0.5 0.7 -1.2
Pack years adult smoking proportion 0.5 0.7 2.5 0.8 1.6 -1.3 -0.1 0.0 0.1 -0.1 1.0 0.5 -0.6 0.3 -1.4
Impedance of leg (right) 0.6 2.8 4.7 -2.0 -2.1 2.0 -0.1 -0.2 -1.5 -1.5 -2.1 -2.0 1.6 0.8 2.2
Leg fat-free mass (left) 0.9 4.7 11.7 -1.7 -1.8 1.6 -2.1 -3.4 -2.6 -0.6 -2.8 -1.4 -0.5 2.2 3.1
Trunk fat percentage 1.2 4.9 9.6 -0.4 -1.2 0.5 -2.2 -2.6 -2.1 -3.1 -3.1 -2.9 -0.5 2.1 3.0
Hand grip strength (right) 0.3 0.8 4.2 -0.3 0.1 -0.2 -0.3 -2.1 -0.6 1.1 -0.1 0.6 -1.2 1.3 0.6
Townsend deprivation index at recruitment 0.4 0.5 2.9 0.8 -0.3 -0.1 0.3 0.6 0.7 -1.7 -0.4 -1.1 0.5 -0.5 0.2
Current tobacco smoking 0.2 0.4 1.7 0.1 -0.0 0.2 1.3 1.1 0.7 0.7 -0.1 0.1 0.5 -0.7 0.5
Average weekly fortified wine intake 1.6 1.8 4.0 1.7 1.3 -1.5 0.9 0.8 1.6 0.9 1.7 2.0 -1.0 -0.6 -1.5
Maternal smoking around birth 0.4 0.5 2.0 1.1 -0.1 -0.5 -0.0 0.1 0.2 -1.4 -0.9 -0.8 -0.2 -0.2 1.1
Fed-up feelings 0.2 0.4 1.7 0.3 0.3 -0.2 0.6 1.3 0.3 -0.9 0.2 -0.6 0.8 -1.0 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 8.7 1.0 -0.6 -0.0 -0.2 1.1 0.7 -3.0 -1.0 -2.0 0.9 -0.9 0.5
Relative age voice broke 0.3 0.4 1.3 0.5 0.8 -0.8 -1.2 -0.0 -0.1 -0.0 0.7 0.3 -0.6 -0.3 -1.0
Taking other prescription medications 0.8 1.2 7.4 0.0 0.5 -0.4 -0.2 1.2 -0.3 -2.7 -0.2 -1.4 1.6 -0.0 -0.8
Age when periods started (menarche) 0.1 0.2 0.7 -0.8 -0.2 0.5 -0.1 -0.3 -0.3 0.5 0.1 -0.0 0.1 0.6 -0.3
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.6 1.2 0.6 -1.0 -0.9 -0.6 0.5 -1.3 0.1 -0.9 -0.9 0.1 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.9 0.1 0.9 -0.6 -0.2 0.3 0.1 0.8 0.7 0.5 -0.4 -0.0 -0.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.4 -0.3 -0.5 0.4 -0.6 -0.2 -0.4 -0.6 -0.2 -0.4 0.2 -0.1 0.2
Qualifications: CSEs or equivalent 0.1 0.2 0.6 -0.8 -0.5 0.7 0.2 0.0 -0.3 0.2 -0.4 -0.5 0.4 -0.1 0.5
Serious illness, injury or assault to yourself 0.8 1.0 2.8 1.2 1.2 -1.3 -1.4 -0.6 0.2 -0.2 0.8 1.0 -1.7 -0.1 -0.8
High blood pressure 0.1 0.4 1.1 -0.6 -0.1 0.2 -0.9 -0.7 -1.1 -1.0 -0.6 -0.2 0.0 0.7 0.5
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.0 -1.1 -1.0 1.0 0.1 0.5 -0.9 -1.3 -0.9 -1.1 1.7 0.5 0.1
Multivitamins +/- minerals 0.2 0.2 0.8 -0.1 0.2 0.0 -0.9 0.2 0.1 0.6 0.6 0.3 -0.6 -0.5 -0.6
Stomach or abdominal pain in last month 0.1 0.1 0.4 -0.3 -0.5 0.6 -0.5 -0.1 -0.2 0.3 -0.3 -0.2 -0.1 -0.1 0.4
Supplements: Glucosamine 0.9 1.1 3.0 -1.2 -0.3 0.6 -1.5 -1.7 -1.5 0.9 -0.6 -0.1 -0.7 1.5 0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.5 0.2 0.3 -0.1 0.7 0.6 0.3 0.2 -0.0 0.1 0.5 -0.2 0.0
Medication: Atenolol 0.2 0.3 0.8 -0.3 0.1 0.0 -0.6 -0.4 -0.6 -0.9 -0.5 -0.7 0.1 0.8 0.2
Medication: Levothyroxine sodium 0.4 0.6 3.0 -0.2 -0.7 0.8 -0.2 0.7 0.4 1.2 -0.4 -0.1 -0.3 -1.7 0.9
Sitting height 0.5 3.5 10.6 -1.4 -1.2 1.0 -1.9 -3.3 -2.3 0.5 -2.1 -0.5 -0.9 2.4 2.6
Chronic bronchitis/emphysema (father) 1.1 1.3 3.0 1.2 1.0 -1.0 0.7 0.9 1.5 0.3 1.6 1.3 -0.3 -1.2 -1.7
High blood pressure (mother) 0.5 0.7 1.9 -1.4 -0.4 0.8 -0.9 -1.3 -1.2 0.8 -0.2 0.3 -0.3 1.0 0.3
Body mass index (BMI) 0.1 0.6 2.0 0.5 0.2 -0.4 -1.0 -1.4 -0.5 -0.7 -0.7 -0.5 -1.0 0.6 0.8
Impedance of leg (left) 0.5 2.3 4.9 -1.7 -2.2 2.1 0.7 0.9 -0.7 -0.7 -1.7 -1.6 1.7 -0.2 2.0
Leg predicted mass (left) 0.9 4.8 11.7 -1.7 -1.9 1.6 -2.0 -3.4 -2.6 -0.5 -2.8 -1.4 -0.5 2.2 3.2
Trunk fat mass 1.4 5.9 12.7 -1.2 -1.9 1.3 -2.2 -3.0 -2.5 -2.4 -3.5 -2.8 -0.3 2.3 3.6
Waist circumference 0.6 2.3 6.6 -1.1 -1.8 1.6 -0.3 -1.0 -1.2 -1.1 -2.4 -1.8 0.8 0.6 2.6
Number of incorrect matches in round 0.1 0.2 0.5 -0.2 0.2 -0.1 -0.7 -0.6 -0.3 -0.3 -0.3 -0.3 -0.5 0.7 0.3
Past tobacco smoking 0.5 0.9 2.6 -1.6 -1.0 1.2 0.2 -0.9 -1.1 0.2 -0.8 -0.5 0.7 1.3 0.9
Alcohol usually taken with meals 2.1 3.4 6.9 0.8 2.3 -1.9 -1.3 -1.2 0.1 1.6 2.4 2.4 -2.6 0.9 -2.6
Nervous feelings 0.2 0.3 1.0 0.8 1.0 -0.9 0.4 0.6 0.6 0.3 0.5 0.3 -0.2 -0.5 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 4.3 2.0 1.2 -1.7 -1.4 0.4 1.1 -2.1 0.3 -0.7 -1.1 -0.5 -0.9
Hearing difficulty/problems with background noise 1.6 2.6 8.9 3.0 2.4 -2.8 -0.3 0.6 1.6 -1.3 1.0 0.2 -1.3 -0.5 -1.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.0 -0.1 0.0 -0.2 -0.5 -0.1 -0.3 -0.0 -0.2 -0.4 0.5 -0.1
Had menopause 1.2 1.5 5.0 0.7 0.2 -0.3 1.8 2.2 1.6 -0.9 0.3 -0.7 1.7 -1.5 -0.6
Had other major operations 0.4 0.5 1.3 0.8 0.8 -0.9 -0.5 -0.5 0.2 -0.5 0.7 0.6 -0.6 0.8 -1.1
Forced vital capacity (FVC) 0.7 2.8 9.1 -1.5 -0.2 0.3 -1.8 -3.0 -2.5 -0.0 -1.2 -0.2 -0.7 2.9 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.4 0.6 1.2 -0.9 0.1 0.5 0.3 0.5 0.9 0.6 -0.3 -0.2 -0.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.5 0.2 0.3 -0.3 -0.6 -0.2 -0.2 -0.7 0.0 -0.3 -0.3 0.6 -0.3
Qualifications: None of the above 2.2 4.7 10.1 -1.2 -2.7 2.6 1.8 2.2 0.3 -1.6 -2.2 -2.9 3.2 -1.4 2.3
Financial difficulties in last 2 years 1.0 1.3 5.9 2.4 1.6 -2.0 0.3 0.0 1.1 -0.7 0.2 0.3 -0.9 -0.1 -0.1
Mouth/teeth dental problems 2.1 3.2 6.0 -2.5 -2.2 2.2 -0.6 -0.7 -1.9 -1.4 -2.0 -2.2 2.0 0.9 1.5
Heart attack 0.5 0.7 1.4 1.1 0.9 -0.9 -1.2 -0.1 0.1 -1.2 0.2 -0.7 -1.1 -0.2 -0.6
Allergy 0.1 0.2 0.9 0.3 0.5 -0.4 -0.2 -0.7 0.2 0.5 0.1 0.2 -1.0 0.1 0.4
Pain all over the body in last month 0.5 0.5 1.6 -1.2 -1.0 1.2 -0.8 -0.4 -0.7 0.0 -0.5 -0.3 -0.0 0.3 0.5
Diabetes (self-reported) 0.9 1.4 5.6 -0.1 -1.5 0.9 -0.4 -0.3 -0.4 -2.4 -1.6 -1.8 0.7 -0.1 1.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.6 -0.1 0.2 -0.1 -0.2 -0.1 -0.2 -0.3 0.5 0.3 0.0 0.5 -0.8
Medication: Ramipril 2.9 3.8 13.3 -1.2 -1.1 0.8 -1.0 -0.9 -1.8 -3.6 -2.4 -3.1 1.6 1.8 1.6
Medication: Simvastatin 3.6 5.3 8.7 -2.4 -2.1 2.0 -1.5 -1.3 -2.9 -2.9 -2.7 -2.8 2.1 2.1 2.0
Fluid intelligence score 2.0 4.1 8.7 2.0 2.8 -2.7 -0.1 0.1 1.2 1.5 2.7 2.4 -2.0 -0.3 -3.0
Illnesses of siblings 0.3 0.4 0.8 0.6 -0.4 0.1 0.9 0.8 0.9 -0.6 -0.1 -0.9 0.5 -0.7 0.1
Neuroticism score 0.4 0.8 2.6 0.8 0.9 -1.0 -1.6 -0.9 -0.3 -0.9 0.3 0.0 -1.4 0.5 -0.5
Weight 1.0 5.0 11.8 -1.7 -2.0 1.7 -1.8 -3.1 -2.6 -1.1 -3.1 -2.0 -0.1 2.1 3.4
Impedance of arm (right) 0.9 4.4 12.5 -0.7 -0.7 0.1 -1.8 -2.0 -2.1 -3.5 -2.6 -3.0 0.3 2.7 2.0
Arm fat percentage (right) 0.7 2.7 5.8 0.2 -0.1 -0.3 -1.9 -2.4 -1.5 -2.3 -2.0 -1.9 -0.9 1.8 1.9
Trunk fat-free mass 0.7 4.1 7.6 -2.8 -2.4 2.6 -0.9 -2.5 -2.4 1.3 -2.2 -0.5 0.5 1.5 2.7
Hip circumference 0.9 3.8 8.9 -1.2 -1.5 1.1 -2.2 -3.0 -2.4 -1.3 -2.5 -1.4 -0.6 2.0 2.6
Time employed in main current job 1.9 2.2 5.3 -1.4 -2.1 2.3 1.1 2.0 0.5 0.2 -0.4 -0.9 2.1 -2.0 0.6
Alcohol intake versus 10 years previously 1.0 1.5 5.6 1.6 2.4 -2.1 1.0 0.6 1.2 0.1 1.1 0.2 -0.5 -0.1 -1.2
Father’s age at death 0.6 0.9 2.5 -0.2 -0.6 0.7 1.4 1.6 0.6 1.2 -0.0 0.3 1.1 -1.4 0.4
Worrier / anxious feelings 0.8 1.4 5.6 0.5 0.4 -0.7 -2.1 -1.4 -1.0 -2.4 -0.6 -1.0 -0.7 1.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 2.7 1.0 -0.6 -0.1 0.2 0.7 0.8 -1.6 -0.8 -0.8 0.3 -1.1 1.0
Falls in the last year 0.3 0.4 1.3 1.1 0.8 -0.9 0.5 0.4 0.9 -1.0 0.1 -0.1 0.1 -0.4 -0.3
Hair/balding pattern: Pattern 3 2.3 3.5 7.7 -2.8 -1.9 2.0 -0.5 -1.5 -2.4 -0.2 -2.3 -1.1 1.3 2.0 2.5
Number of live births 1.6 2.2 4.8 -0.7 -2.2 1.9 0.7 1.2 -0.1 -1.5 -1.6 -2.0 1.8 -0.7 1.8
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 15.1 -1.7 -0.3 0.3 -2.9 -3.9 -3.2 -0.8 -1.7 -0.7 -1.2 3.6 1.4
Pulse rate 2.4 4.0 10.3 -2.3 -3.2 3.0 0.9 0.2 -1.1 -1.1 -2.2 -1.9 2.4 0.0 2.4
Happiness 3.1 3.7 6.9 2.0 1.5 -1.5 0.2 1.9 2.3 1.4 2.6 2.2 -1.3 -2.4 -2.5
Noisy workplace 1.1 1.3 4.2 0.7 -0.5 0.3 1.9 2.0 1.6 0.1 0.0 -0.5 1.2 -1.7 0.2
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.8 -0.0 1.3 -0.9 -1.2 -0.8 -0.3 0.9 1.7 1.8 -1.3 0.6 -2.2
Serious illness, injury or assault of a close relative in last 2 years 3.7 4.2 8.1 2.8 2.2 -2.3 0.4 1.5 2.6 0.7 2.5 2.0 -1.5 -2.0 -2.5
Mouth/teeth dental problems: Dentures 4.7 7.9 12.0 3.2 3.4 -3.1 1.5 1.9 3.2 2.7 3.5 3.1 -2.4 -2.0 -3.0
Asthma 0.1 0.2 1.1 0.4 0.1 -0.2 -0.0 0.1 0.1 -1.1 0.2 -0.2 0.5 0.2 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 3.3 1.2 1.6 -1.8 -1.3 -0.9 -0.2 -0.6 0.5 0.4 -1.7 0.7 -0.7
Medication: Cholesterol lowering 0.2 0.3 1.5 0.4 0.3 -0.3 -1.0 0.2 -0.6 -1.2 0.0 -0.6 0.0 -0.1 -0.4
Depression (self-reported) 1.0 1.2 2.7 1.3 1.4 -1.3 1.1 1.6 1.1 0.4 1.1 0.8 0.2 -1.2 -1.1
Medication: Lansoprazole 0.9 1.0 2.1 -1.2 -1.1 1.4 0.2 0.9 -0.5 -0.7 -1.1 -1.5 1.3 0.0 1.0
Prospective memory result 1.7 2.1 4.2 0.2 -1.4 1.2 1.8 2.0 1.3 -0.4 -1.1 -1.5 1.3 -2.0 1.9
Lung cancer (father) 0.5 0.6 2.7 0.3 -0.2 0.1 -1.1 -1.0 -0.1 1.0 0.1 1.0 -1.7 0.1 0.3
Illnesses of mother 0.6 0.7 1.7 -0.6 -0.9 0.7 -0.2 -0.5 -0.7 -1.2 -1.0 -1.3 0.5 1.0 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 4.9 -0.5 0.2 -0.3 -1.6 -2.2 -1.5 -0.3 -0.7 -0.1 -1.2 1.9 0.7
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 0.0 0.5 -0.4 -1.1 -1.2 -0.5 0.6 0.3 0.7 -1.2 0.5 -0.1
Impedance of arm (left) 0.7 3.3 11.9 -0.5 -0.8 0.1 -1.5 -1.4 -1.7 -3.5 -2.2 -2.6 0.3 2.2 1.7
Arm fat mass (right) 0.7 3.0 6.9 -0.4 -0.9 0.4 -1.7 -2.6 -1.8 -1.7 -2.4 -1.8 -0.6 1.8 2.5
Trunk predicted mass 0.7 4.0 7.6 -2.8 -2.4 2.6 -0.9 -2.4 -2.3 1.4 -2.2 -0.4 0.5 1.4 2.7
Standing height 1.5 15.2 30.7 -4.7 -4.5 4.3 -2.2 -4.1 -4.6 -0.6 -5.0 -2.9 1.4 3.6 5.5
Length of working week for main job 1.9 2.1 4.4 1.3 1.9 -1.9 -0.6 -0.9 0.6 0.9 1.8 2.1 -1.8 0.3 -1.8
Exposure to tobacco smoke at home 1.2 1.4 5.0 -0.8 -1.0 0.7 0.4 -0.0 -0.3 -2.2 -1.1 -1.9 1.8 1.0 0.4
Breastfed as a baby 2.1 2.6 5.2 1.7 1.3 -1.4 0.8 1.5 2.1 1.2 2.2 1.8 -0.8 -1.5 -2.3
Tense / ‘highly strung’ 0.2 0.4 1.0 -0.0 0.3 -0.3 -0.9 -0.8 -0.7 -1.0 -0.3 -0.6 -0.2 1.0 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.5 0.7 0.4 -0.6 -0.1 0.9 0.5 -1.2 0.3 -0.1 -0.0 -0.0 -0.6
Hair/balding pattern: Pattern 4 3.8 9.1 19.5 3.8 2.0 -2.2 2.6 3.8 4.4 1.5 3.2 2.2 -0.6 -4.4 -2.8
Birth weight of first child 1.8 3.3 9.2 -1.4 -0.6 0.4 -2.0 -3.0 -2.7 -1.6 -1.7 -1.3 -0.1 3.0 1.1
Peak expiratory flow (PEF) 0.8 1.8 6.5 -0.3 0.5 -0.5 -2.5 -2.4 -1.4 0.3 0.2 0.7 -1.8 1.8 -0.3
Pulse wave reflection index 1.9 2.3 8.0 1.2 1.8 -1.8 -1.8 -2.0 -0.1 1.1 0.7 1.4 -2.8 1.2 -0.5
Ever highly irritable/argumentative for 2 days 1.1 1.3 4.1 0.2 0.4 -0.6 -1.2 -1.7 -1.1 -1.5 -1.2 -0.9 -0.7 2.0 1.0
Loud music exposure frequency 0.4 0.5 1.6 0.9 -0.2 -0.1 -0.4 0.9 1.1 0.1 0.6 0.5 -0.5 -1.3 -0.4
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 6.0 0.4 1.7 -1.2 -0.3 -0.3 0.1 1.2 2.1 2.1 -1.2 0.4 -2.4
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 4.9 0.2 0.3 -0.6 -1.7 -2.2 -1.4 -1.4 -0.5 -0.0 -1.0 2.0 0.1
Blood clot in the leg (DVT) 2.2 2.9 7.7 0.8 -0.2 0.1 2.0 1.6 2.3 2.8 1.5 2.5 -0.1 -2.3 -0.6
Medication: Paracetamol 0.5 0.9 3.6 -0.4 0.1 -0.1 -1.1 -0.7 -1.4 -1.9 -0.9 -0.9 0.4 1.0 0.5
Headache pain in last month 0.5 0.9 2.6 0.9 1.0 -1.1 -0.8 -1.3 0.0 0.1 0.6 1.1 -1.6 0.7 -0.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 2.6 -0.2 -0.3 0.3 1.6 0.3 0.7 0.6 0.1 0.4 0.7 -0.1 -0.0
Glaucoma (self-reported) 0.1 0.1 0.4 -0.3 -0.3 0.3 0.4 0.6 0.2 0.0 -0.0 0.1 0.6 -0.3 0.1
Gout (self-reported) 0.3 0.4 2.2 -0.2 0.4 -0.3 0.0 -0.2 -0.4 -1.5 -0.3 -0.7 0.9 0.8 -0.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.9 0.5 -0.2 0.0 0.9 1.2 1.0 0.3 -0.3 -0.3 0.4 -1.7 0.6
Medication: Amlodipine 0.3 0.4 2.4 -0.3 -0.3 0.4 1.6 0.6 0.0 0.4 -0.1 0.0 0.9 -0.1 0.4
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.8 -0.7 -0.9 0.8 -0.1 -0.1 -0.5 -0.5 -0.4 -0.3 0.7 0.1 0.2
Birth weight 2.2 4.7 11.6 -1.7 -0.9 0.8 -2.4 -3.4 -3.0 -1.8 -2.2 -1.8 -0.4 3.3 1.8
Chronic bronchitis/emphysema (mother) 2.2 2.5 5.2 -1.2 -1.9 1.6 -1.1 -0.5 -1.6 -2.3 -2.1 -2.1 1.0 1.0 1.6
High blood pressure (siblings) 0.2 0.3 1.0 -0.9 -0.3 0.6 -0.3 -0.1 -0.5 1.0 -0.1 0.7 0.1 0.1 0.3
Forced vital capacity (FVC), Best measure 0.3 1.0 3.7 -0.2 0.8 -0.8 -1.0 -1.9 -1.1 0.2 0.0 0.5 -1.1 1.9 -0.1
Body fat percentage 0.9 3.7 7.8 -0.5 -1.3 0.7 -1.9 -2.2 -1.8 -2.5 -2.8 -2.6 -0.4 1.6 2.8
Leg fat percentage (right) 0.5 1.9 4.5 -0.4 -1.2 0.8 -1.1 -1.2 -1.2 -1.9 -2.1 -2.0 0.1 0.7 2.1
Arm fat-free mass (right) 0.7 3.4 8.0 -2.3 -2.6 2.7 -0.6 -1.6 -1.8 1.0 -2.2 -0.6 0.6 0.7 2.8
Exposure to tobacco smoke outside home 0.8 1.0 2.3 -1.1 -1.2 1.3 -0.5 0.5 -0.6 -1.2 -1.1 -1.3 1.5 0.1 0.6
Comparative body size at age 10 0.6 1.7 4.5 -1.7 -1.8 2.1 1.4 1.3 -0.0 0.7 -0.7 -0.6 1.7 -0.9 1.0
Number of full brothers 1.3 1.7 3.5 1.0 1.9 -1.5 0.4 0.1 0.9 1.8 1.6 1.6 -1.2 0.0 -1.6
Worry too long after embarrassment 0.6 1.0 4.0 0.6 0.8 -0.9 -2.0 -1.4 -0.5 -0.1 0.1 0.3 -1.8 0.6 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.0 1.4 0.9 -1.4 -0.3 -0.1 0.5 -1.4 0.5 0.4 -0.4 0.2 -0.8
Wheeze or whistling in the chest in last year 0.6 1.0 3.1 1.3 0.4 -0.5 0.9 1.5 1.4 -0.1 0.8 0.3 0.1 -1.8 -0.8
Number of children fathered 0.9 1.0 2.9 0.7 1.4 -1.4 0.6 -0.4 0.4 0.1 1.3 1.1 -0.5 0.9 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.2 0.5 -0.4 -0.1 -0.0 0.6 0.4 -1.1 -0.2 -0.5 0.3 -0.4 0.1
Age at first live birth 0.8 1.4 2.5 1.1 1.2 -1.2 1.4 1.4 1.5 0.5 1.3 0.8 0.3 -0.8 -1.6
Pulse wave peak to peak time 0.4 0.5 1.4 -0.2 -0.6 0.5 1.0 1.1 0.3 -0.4 -0.4 -0.7 1.2 -0.5 0.3
Health satisfaction 1.1 1.4 4.2 -0.6 -1.4 1.0 -1.0 -0.5 -1.1 -2.0 -1.5 -1.5 0.4 0.4 1.4
Shortness of breath walking on level ground 2.0 2.3 6.1 -0.0 -1.6 0.9 -0.6 0.0 -0.7 -2.4 -2.3 -2.5 0.8 -0.2 2.4
Qualifications: College or University degree 0.9 2.9 6.5 1.4 2.0 -2.1 -1.2 -1.2 0.4 1.5 1.9 2.6 -2.3 0.6 -1.9
Eye problems/disorders: None of the above 1.0 1.2 3.7 0.4 0.5 -0.1 1.2 1.5 1.0 1.9 1.2 1.0 0.2 -1.3 -1.0
Mouth/teeth dental problems: Loose teeth 1.3 1.5 4.0 1.0 0.3 -0.3 0.5 1.1 1.4 2.0 1.4 1.7 -1.0 -1.8 -0.6
Emphysema/chronic bronchitis 0.9 1.0 2.4 -0.4 -1.2 1.1 0.5 0.9 0.0 -0.6 -1.2 -1.5 0.8 -1.0 1.5
Medication for pain relief, constipation, heartburn 0.6 1.1 8.1 -0.4 -0.5 0.7 1.0 -0.1 0.4 2.8 0.5 1.2 -0.5 -0.5 0.4
Neck or shoulder pain in last month 0.4 0.6 1.5 1.0 0.9 -1.1 -1.0 -1.0 0.2 -0.8 0.0 0.1 -1.2 0.5 -0.1
Medication: Blood pressure 0.5 0.9 4.0 -0.8 0.4 -0.0 -2.0 -1.1 -1.6 -0.4 -0.4 -0.5 -0.6 1.1 0.3
Angina (self-reported) 0.9 1.1 2.6 1.4 1.5 -1.6 -1.1 -0.8 0.2 -1.0 0.6 -0.0 -1.5 0.5 -0.9
Migraine (self-reported) 3.2 3.9 9.7 2.5 3.1 -3.0 0.0 -0.2 1.3 0.2 2.4 1.9 -1.9 0.2 -2.8
Medication: Ibuprofen 0.6 0.7 1.9 1.1 0.9 -1.4 -0.8 -0.6 -0.1 -1.4 0.1 -0.2 -0.8 0.6 -0.4
Medication: Allopurinol 0.6 0.7 2.3 -0.5 0.3 -0.1 -0.1 -0.8 -1.0 -1.5 -0.8 -1.0 0.8 1.5 0.3
Medication: Omeprazole 2.4 2.9 6.7 -1.9 -0.7 0.8 -1.3 -1.6 -2.4 -2.3 -1.6 -1.7 1.3 2.6 0.7
Medication: Seretide 50 evohaler 0.7 0.8 2.6 -0.9 -1.5 1.6 0.4 0.5 -0.2 0.2 -0.7 -0.7 0.8 -0.7 1.0
Mean time to correctly identify matches 0.6 1.2 4.5 1.0 -0.1 -0.0 -0.0 2.1 1.4 -1.4 0.7 -0.2 0.6 -1.8 -1.1
Heart disease (mother) 0.8 1.0 2.8 0.9 1.7 -1.3 0.4 0.8 0.8 0.8 1.3 0.9 -0.7 -0.4 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.5 -0.0 -0.4 0.6 -0.4 0.2 0.1 0.7 0.1 0.0 -0.3 -0.7 0.2
Whole body fat mass 1.3 5.2 11.8 -1.2 -1.8 1.3 -2.2 -3.0 -2.5 -2.0 -3.2 -2.5 -0.4 2.0 3.4
Leg fat mass (right) 0.9 3.3 8.9 -0.9 -1.7 1.3 -1.6 -2.2 -1.8 -1.5 -2.7 -2.0 -0.2 1.2 3.0
Arm predicted mass (right) 0.7 3.6 8.9 -2.4 -2.8 2.8 -0.6 -1.6 -1.8 0.9 -2.3 -0.7 0.6 0.7 3.0
Pulse rate, automated reading 1.0 3.2 6.6 -1.8 -2.6 2.4 -0.0 -0.4 -1.5 -1.4 -2.3 -2.1 1.5 0.2 2.5
Alcohol intake frequency. 1.1 2.5 5.2 2.1 2.3 -2.2 0.8 0.1 1.7 1.1 1.8 1.6 -1.7 -0.1 -1.4
Comparative height size at age 10 1.7 9.4 19.1 -4.1 -3.8 3.9 -1.0 -2.6 -3.5 0.1 -3.8 -2.2 1.7 2.3 4.4
Number of full sisters 0.3 0.4 1.4 0.1 0.3 -0.3 1.2 0.8 0.5 -0.8 -0.2 -0.6 1.0 -0.0 -0.0
Suffer from ‘nerves’ 0.6 1.0 2.8 -0.8 -0.7 0.8 0.5 1.5 -0.0 -0.9 -0.9 -1.4 1.7 -0.9 0.8
Overall health rating 1.6 3.5 8.1 -1.1 -2.1 1.8 0.1 -0.1 -1.1 -2.8 -2.6 -2.8 1.7 0.5 2.6
Chest pain or discomfort 0.2 0.3 0.7 0.6 0.5 -0.6 -0.7 0.1 0.1 -0.3 0.6 0.8 -0.7 -0.3 -0.8
Had major operations 0.7 0.9 2.3 -0.0 -1.0 0.9 1.1 1.2 0.5 1.0 -0.8 -0.5 0.6 -1.2 1.5
Age at last live birth 0.8 1.1 2.8 1.6 0.9 -1.1 1.0 1.3 1.7 0.2 0.9 0.6 0.0 -1.1 -1.0
Family relationship satisfaction 1.1 1.4 3.3 1.8 1.2 -1.4 -0.2 0.8 1.4 -0.3 1.4 0.7 -1.0 -0.9 -1.6
Leg pain on walking 2.8 3.6 5.5 -2.3 -2.2 2.2 -0.5 -0.9 -2.2 -1.5 -2.3 -1.9 2.0 1.4 2.0
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.1 5.7 -2.4 -1.3 1.7 -0.8 -1.2 -2.1 -0.2 -1.5 -1.2 0.8 1.4 1.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.0 -1.0 -1.0 0.8 -0.7 -0.7 -0.9 -0.6 -0.8 -0.6 0.3 0.4 0.8
Illness, injury, bereavement, stress in last 2 years 5.0 6.1 12.0 -3.4 -3.5 3.4 0.0 -0.4 -2.1 -0.9 -2.9 -2.7 2.5 0.8 3.0
Medication: Aspirin 0.7 0.9 2.8 1.3 0.7 -0.8 0.1 1.2 1.1 -1.7 0.7 -0.3 0.2 -0.9 -1.3
Supplements: Vitamin C 1.3 1.5 4.3 -0.2 1.0 -0.8 -2.0 -1.8 -1.4 -0.4 0.2 0.3 -1.3 2.1 -0.8
Knee pain experienced in last month 1.8 2.8 6.1 -2.0 -1.3 1.4 -0.6 -1.9 -2.4 -1.3 -1.7 -1.2 1.4 2.5 1.3
Hypertension (Self-reported) 0.3 0.9 2.3 -1.2 -0.5 0.7 -1.1 -0.9 -1.5 -1.0 -1.0 -0.5 0.3 1.1 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.2 -1.2 -0.3 0.5 -0.5 -0.4 -1.2 -1.8 -0.7 -1.1 1.0 1.3 -0.0
Illnesses of father: Heart disease 0.6 0.9 2.8 0.8 1.0 -1.0 -0.4 0.4 0.7 -0.0 1.5 1.2 -0.7 -0.6 -1.7
Illnesses of siblings: Diabetes 0.3 0.3 0.8 -0.4 -0.4 0.3 0.5 -0.8 -0.4 -0.4 -0.8 -0.2 0.6 0.7 0.9
Smoking status: Previous 0.3 0.4 1.7 0.9 -0.4 -0.2 -0.1 0.7 0.7 -0.9 -0.2 -0.3 -0.0 -1.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.9 -1.1 -1.4 1.2 -1.1 -1.7 -1.5 0.2 -1.6 -0.7 -0.5 0.9 2.2
Whole body fat-free mass 0.7 4.1 8.6 -2.3 -2.2 2.3 -1.3 -2.8 -2.4 0.6 -2.5 -0.8 0.1 1.7 2.9
Leg fat-free mass (right) 0.6 3.3 8.3 -1.4 -1.6 1.4 -1.6 -2.9 -2.1 -0.0 -2.3 -0.9 -0.5 1.8 2.8
Arm fat percentage (left) 0.6 2.4 5.5 0.2 -0.3 -0.2 -1.7 -2.1 -1.4 -2.3 -2.0 -1.9 -0.7 1.5 1.9
Average weekly red wine intake 0.3 0.4 1.3 0.5 -0.5 0.1 -0.4 -0.9 0.1 0.7 -0.4 0.7 -1.1 -0.2 1.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.0 -0.5 -0.4 0.6 0.9 0.7 0.0 0.8 0.2 0.2 1.0 -0.4 -0.2
Mood swings 0.8 1.5 6.3 -0.1 0.3 -0.5 -2.0 -1.5 -1.2 -2.5 -0.6 -1.1 -0.5 1.4 -0.2
Loneliness, isolation 0.9 1.2 2.3 1.5 1.4 -1.4 -0.3 0.8 1.2 0.3 1.3 0.7 -1.1 -1.0 -1.4
Long-standing illness, disability or infirmity 0.8 1.3 3.4 1.9 1.5 -1.5 -0.0 1.1 1.2 -0.9 0.9 0.0 -0.9 -1.2 -1.1
Ever had bowel cancer screening 1.1 1.3 3.1 -0.1 -1.0 0.9 1.7 1.8 1.2 -0.3 -0.3 -0.9 1.7 -1.5 0.3
Diabetes diagnosed by doctor 2.3 3.8 8.8 -1.2 -2.3 1.8 0.0 -0.3 -1.2 -3.0 -2.6 -2.9 2.0 0.5 2.4
Ever had stillbirth, spontaneous miscarriage or termination 1.8 2.0 8.6 0.6 1.0 -1.1 -1.8 -2.1 -0.5 0.9 0.6 1.3 -2.9 1.3 -0.2
Friendships satisfaction 2.6 3.2 6.9 1.5 0.9 -0.8 2.1 2.6 2.4 1.2 2.0 1.5 0.4 -2.5 -1.8
Qualifications: nursing, teaching 3.4 5.3 10.4 2.7 2.8 -3.0 -1.1 -0.2 1.5 1.1 2.9 2.6 -3.0 -1.0 -3.2
Commuting to job workplace: Walk 0.6 0.6 1.7 0.8 1.3 -1.1 -0.8 -0.1 0.0 -0.1 0.6 0.4 -1.2 0.2 -1.0
Eye problems/disorders: Cataract 4.1 4.7 8.6 -2.0 -1.4 1.2 -2.6 -2.6 -2.9 -2.6 -2.4 -1.9 0.1 2.7 1.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.3 0.3 -0.2 0.2 1.1 0.4 1.0 1.5 0.0 0.7 -0.3 -0.6 0.8
Medication for cholesterol 0.2 0.3 0.6 0.8 0.7 -0.7 0.1 0.2 0.6 0.7 0.8 0.4 -0.6 -0.3 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.4 4.0 11.0 -0.1 -2.1 1.6 2.4 3.3 1.8 -1.2 -0.6 -1.2 3.3 -2.6 0.6
Back pain experienced in last month 0.4 0.6 2.9 0.7 0.6 -0.8 -0.9 -0.6 -0.4 -1.7 -0.5 -0.8 -0.2 0.6 0.3
Mineral and other dietary supplements 1.0 1.3 3.4 1.9 1.0 -1.3 1.2 1.0 1.7 0.2 1.0 0.9 -0.3 -1.2 -1.0
Breast cancer (self-reported) 0.1 0.1 0.4 -0.2 -0.2 0.2 0.5 0.1 0.4 0.6 0.5 0.5 0.1 -0.2 -0.4
Asthma (self-reported) 0.1 0.2 0.8 0.5 0.3 -0.4 -0.0 -0.0 0.1 -0.9 0.4 0.1 0.2 0.2 -0.8
Osteoporosis (self-reported) 0.4 0.5 2.4 0.7 0.8 -1.0 -0.4 -0.4 -0.2 -1.5 -0.2 -0.6 -0.5 0.6 -0.2
Osteoarthritis (self-reported) 0.8 1.1 2.9 -1.4 -0.7 0.8 -1.7 -1.2 -1.7 -0.7 -0.7 -0.1 0.2 1.3 0.5
Medication: Aspirin 0.8 1.1 2.5 1.5 0.5 -0.7 0.3 1.5 1.4 -1.6 0.6 -0.4 0.2 -1.2 -1.1
Medication: Gliclazide 0.8 0.9 2.0 -0.8 -1.3 1.0 -0.7 0.0 -0.7 -1.4 -1.1 -1.3 0.8 -0.5 0.8
Illnesses of father: None of the above (group 1) 2.3 2.8 5.5 -1.7 -2.2 2.1 -0.8 -1.4 -1.6 -0.6 -2.3 -1.9 0.5 1.2 2.3
Smoking status: Current 0.3 0.5 1.7 0.1 -0.0 0.3 1.3 1.2 0.7 0.8 -0.2 0.0 0.5 -0.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.1 1.1 1.3 -1.5 -0.7 -0.7 0.1 -0.8 0.6 0.5 -1.2 0.6 -0.9
Whole body water mass 0.7 3.8 8.1 -2.3 -2.2 2.2 -1.2 -2.6 -2.3 0.7 -2.4 -0.7 0.2 1.6 2.9
Leg predicted mass (right) 0.6 3.4 8.4 -1.4 -1.6 1.4 -1.6 -2.9 -2.1 -0.1 -2.4 -1.0 -0.5 1.8 2.8
Arm fat mass (left) 0.7 2.8 6.3 -0.4 -0.8 0.4 -1.8 -2.5 -1.7 -1.8 -2.3 -1.8 -0.6 1.7 2.3
Number of self-reported non-cancer illnesses 0.7 1.3 2.3 1.5 1.1 -1.2 -0.9 1.2 1.0 -1.2 0.9 0.3 -0.5 -1.4 -1.5
Average weekly champagne plus white wine intake 1.6 2.2 5.9 1.0 1.9 -1.9 -1.5 -1.7 -0.3 0.9 1.0 1.4 -2.4 1.2 -1.1
Miserableness 0.5 0.9 2.6 1.4 1.0 -1.2 -1.1 -0.6 0.4 -0.1 0.8 1.0 -1.6 -0.1 -0.8
Guilty feelings 2.5 3.7 7.3 2.3 2.6 -2.6 -0.7 -0.0 1.1 0.6 2.5 2.1 -2.3 -0.3 -2.7
Wears glasses or contact lenses 1.7 1.9 4.2 1.7 1.8 -2.1 -1.3 -1.2 0.4 -0.9 1.1 0.7 -1.8 0.9 -1.8
Ever taken oral contraceptive pill 0.4 0.4 0.8 -0.6 -0.4 0.2 -0.1 -0.7 -0.9 -0.6 -0.9 -0.6 0.3 0.9 0.9
Hearing aid user 0.8 0.9 2.6 0.4 -0.7 0.4 1.6 1.6 1.0 -0.6 -0.2 -0.6 1.2 -1.3 0.3
Mother’s age at death 2.2 2.8 4.8 1.6 1.8 -1.8 0.5 0.3 1.6 1.8 2.2 2.2 -1.9 -0.7 -2.0
Financial situation satisfaction 1.6 2.0 6.4 0.2 -0.8 0.6 1.6 2.5 1.0 -1.6 -0.6 -1.7 2.2 -1.5 0.4
Tinnitus: Yes, now most or all of the time 4.2 4.9 12.3 2.8 1.6 -1.8 3.0 2.8 3.5 1.3 1.9 1.3 -0.0 -2.5 -1.6
Commuting to job workplace: Public transport 2.9 3.5 6.3 2.2 2.3 -2.1 -0.4 1.0 1.6 1.3 2.4 2.2 -2.0 -1.2 -2.5
Eye problems/disorders: Glaucoma 0.7 0.8 2.1 -1.1 -1.4 1.3 1.0 0.5 -0.1 -0.0 -0.7 -0.5 1.5 0.0 0.8
Medication: Blood pressure 0.8 1.6 3.6 -1.0 -1.4 1.2 -1.1 -0.9 -1.2 -1.9 -1.7 -1.4 0.6 0.6 1.6
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.1 1.4 1.4 -1.4 0.8 0.6 0.7 -0.4 0.5 0.1 -0.1 0.1 -0.6
Supplements: Fish oil (including cod liver oil) 1.0 1.4 3.4 -1.9 -1.0 1.3 -1.5 -1.0 -1.6 -0.6 -1.0 -0.9 0.3 1.3 0.7
High cholesterol (Self-reported) 0.3 0.5 2.1 0.5 0.6 -0.6 -0.0 0.8 -0.1 -1.4 -0.0 -0.7 1.0 -0.1 -0.5
Medication: Bendroflumethiazide 0.9 1.4 4.6 -0.8 -0.9 0.6 -2.2 -1.0 -1.6 -2.0 -1.1 -0.7 0.1 0.8 0.6
Medication: Paracetamol 1.2 1.8 4.0 -1.1 -0.7 0.6 -1.3 -1.2 -1.9 -2.0 -1.7 -1.3 0.7 1.3 1.4
Medication: Lisinopril 1.1 1.4 5.0 0.9 1.1 -1.2 -1.6 -0.8 0.1 0.8 1.3 1.5 -2.2 -0.2 -1.1
Medication: Atorvastatin 0.7 0.8 3.2 1.4 0.2 -0.4 0.3 1.5 1.2 -0.1 0.5 0.2 -0.5 -1.8 -0.3
Illnesses of father: High blood pressure 1.0 1.3 2.2 -1.4 -1.1 1.0 -0.2 -0.8 -1.4 -0.8 -1.5 -1.0 0.9 1.3 1.4
Alcohol drinker status: Never 1.0 1.2 3.6 1.1 0.2 -0.3 1.9 1.9 1.7 0.5 0.1 -0.0 0.5 -1.6 0.6
Ever smoked 1.7 3.0 6.6 2.0 2.4 -2.1 -0.3 0.9 1.3 0.8 2.2 2.0 -1.4 -1.1 -2.6
Basal metabolic rate 0.9 4.8 11.0 -2.3 -2.4 2.3 -1.4 -2.9 -2.6 0.1 -2.8 -1.3 0.2 1.9 3.3
Leg fat percentage (left) 0.3 1.2 3.3 -0.2 -1.1 0.7 -0.6 -0.5 -0.6 -1.5 -1.7 -1.7 0.2 0.1 1.8
Arm fat-free mass (left) 0.7 3.4 8.5 -2.2 -2.3 2.3 -0.8 -2.0 -1.9 0.7 -2.4 -0.9 0.4 1.1 2.9
Number of operations (self-reported) 0.5 0.7 2.2 1.5 0.8 -1.1 0.0 0.2 1.2 0.7 0.6 0.8 -1.2 -0.5 -0.2
Average weekly beer plus cider intake 0.5 0.7 1.2 0.6 0.8 -0.9 -0.7 -1.0 -0.7 -1.1 -0.7 -0.7 -0.6 1.1 0.6
Irritability 0.5 0.8 2.4 1.0 1.5 -1.5 -0.7 -0.8 -0.1 -0.4 0.5 0.6 -1.1 0.5 -0.5
Risk taking 0.9 1.3 5.0 0.1 0.6 -0.8 -1.7 -2.2 -1.2 -1.0 0.0 0.3 -1.2 1.6 -0.4
Ever had prostate specific antigen (PSA) test 0.8 1.0 2.2 0.6 1.0 -0.8 -1.0 -0.2 0.5 1.1 1.2 1.3 -1.5 -0.4 -1.2
Fractured/broken bones in last 5 years 0.7 0.9 2.0 1.2 1.4 -1.3 1.3 0.7 1.0 0.4 0.9 0.8 0.1 0.1 -1.0
Age started oral contraceptive pill 0.5 0.6 1.6 0.5 0.4 -0.3 0.7 1.3 0.7 -0.5 0.8 0.3 0.5 -1.1 -1.2
Diastolic blood pressure, automated reading 1.2 3.9 9.0 -1.7 -2.2 1.8 -1.8 -2.5 -2.3 -0.9 -2.6 -1.4 -0.3 1.6 3.0
Ever depressed for a whole week 0.1 0.1 0.9 0.4 -0.2 -0.0 -0.6 -0.1 -0.1 -0.9 -0.0 -0.1 -0.2 0.2 -0.2
Unable to work because of sickness or disability 0.7 0.9 3.2 -0.2 -1.2 1.2 0.7 1.5 0.9 -0.1 -0.2 -0.4 0.7 -1.8 0.5
Commuting to job workplace: Cycle 0.3 0.3 1.2 0.7 0.5 -0.8 1.1 0.4 1.0 0.1 0.2 0.3 0.3 -0.2 0.0
Myopia 0.5 0.7 2.9 -0.6 -0.3 0.3 0.3 0.5 -0.1 -1.5 -0.5 -1.2 1.7 0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.9 -0.2 -0.5 0.4 1.0 0.3 0.5 0.8 0.1 0.0 0.6 -0.1 -0.1
Cholesterol lowering medication 1.5 2.3 5.2 -1.6 -2.0 1.8 0.9 0.5 -0.6 -1.2 -1.9 -1.6 2.3 0.1 1.8
Medication: Omeprazole (e.g. Zanprol) 2.6 3.1 8.2 -2.2 -0.6 0.9 -1.3 -1.8 -2.7 -2.0 -1.6 -1.4 1.4 2.9 0.6
Pain experienced in last month 0.4 0.6 1.8 -0.4 -0.7 0.7 1.0 1.3 0.5 0.3 0.3 -0.2 1.1 -1.3 -0.4
Supplements: Calcium 0.3 0.4 1.3 0.1 -0.1 -0.2 -1.2 -0.9 -0.6 -0.8 -0.4 -0.4 -0.7 0.5 0.3
Basal cell carcinoma (self-reported) 0.3 0.3 1.1 -0.3 -0.7 0.6 1.1 0.2 0.2 0.3 -0.5 -0.3 0.6 -0.0 0.9
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.7 1.3 1.1 -1.1 -1.1 -0.2 0.1 -1.2 0.3 -0.5 -1.1 -0.0 -0.7
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 7.0 0.7 -0.1 0.1 2.0 1.4 2.2 2.6 1.4 2.4 -0.2 -2.0 -0.6
Heart disease (siblings) 0.2 0.3 0.8 -0.6 0.4 -0.0 0.4 0.4 -0.1 0.3 0.7 0.8 0.5 0.4 -0.9
Alcohol drinker status: Previous 0.8 0.9 2.0 0.7 1.0 -1.0 -0.8 -0.8 -0.0 0.6 1.1 1.4 -1.4 0.4 -1.1
Pack years of smoking 0.6 0.9 2.9 1.0 1.7 -1.4 0.0 0.4 0.4 -0.1 1.2 0.5 -0.6 -0.1 -1.6
Impedance of whole body 0.5 2.6 6.3 -1.0 -1.5 1.0 -0.7 -0.5 -1.3 -2.5 -2.3 -2.5 0.9 1.3 2.1
Leg fat mass (left) 0.8 3.2 8.6 -1.0 -1.8 1.4 -1.5 -2.0 -1.8 -1.4 -2.6 -2.0 -0.1 1.0 2.9
Arm predicted mass (left) 0.8 4.1 9.7 -2.4 -2.5 2.6 -1.0 -2.3 -2.1 0.8 -2.5 -0.9 0.3 1.2 3.1