Hub : Genes

KCTD7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0880	0.0400	9.1e-08	0.104	NA	0.102	NA	0.105	3.6e-08	NA	4.8e-08	NA	2.7e-08
2	GTEx	Esophagus Mucosa	0.0440	0.0230	1.1e-03	0.040	NA	0.044	NA	0.049	1.1e-03	NA	5.9e-04	NA	3.2e-04
3	GTEx	Muscle Skeletal	0.0369	0.0219	9.1e-03	0.024	NA	0.007	NA	0.008	1.7e-03	NA	6.4e-02	NA	5.3e-02
4	GTEx	Nerve Tibial	0.1798	0.0647	9.1e-11	0.163	NA	0.168	NA	0.146	1.3e-11	NA	5.6e-12	NA	1.7e-10
5	GTEx	Skin Not Sun Exposed Suprapubic	0.0620	0.0340	2.4e-03	0.056	NA	0.034	NA	0.020	5.3e-04	NA	5.6e-03	NA	2.9e-02
6	GTEx	Skin Sun Exposed Lower leg	0.0410	0.0230	6.8e-04	0.026	NA	0.043	NA	0.042	3.2e-03	NA	1.8e-04	NA	2.0e-04
7	GTEx	Testis	0.2050	0.0650	2.3e-09	0.238	NA	0.197	NA	0.209	6.3e-11	NA	4.1e-09	NA	1.3e-09
8	METSIM	Adipose	0.0541	0.0239	7.4e-05	0.035	0.042	0.041	0.041	0.038	4.6e-06	5.5e-07	7.6e-07	7.2e-07	2.0e-06
9	ROSMAP	Brain Pre-frontal Cortex	0.0839	0.0301	3.8e-12	0.070	0.081	0.083	0.077	0.075	2.5e-09	1.3e-10	8.4e-11	3.4e-10	6.0e-10
10	TCGA	Breast Invasive Carcinoma	0.0262	0.0137	1.8e-06	0.028	0.031	0.026	NA	0.026	1.8e-06	4.9e-07	3.5e-06	NA	3.8e-06
11	TCGA	Lung Squamous Cell Carcinoma	0.0351	0.0291	3.1e-03	0.021	0.015	0.014	NA	0.014	1.5e-03	6.7e-03	8.9e-03	NA	8.1e-03
12	TCGA	Prostate Adenocarcinoma	0.0250	0.0177	7.2e-03	0.007	0.012	0.003	NA	0.008	6.1e-02	1.6e-02	1.5e-01	NA	4.1e-02
13	TCGA	Thyroid Carcinoma	0.0420	0.0280	6.3e-04	0.039	0.034	0.037	NA	0.034	1.0e-04	2.5e-04	1.4e-04	NA	2.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.9	3.1	9.1	-1.7	-1.8	-1.8	-3.0	-2.7	-1.6	-1.1	-1.5	2.5	-0.4	-0.6	-0.7	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.1	3.4	-0.7	-1.0	-1.4	-1.8	-1.7	-0.8	-0.8	-0.5	1.9	-0.0	-0.2	-0.4	-0.3
Depressed Affect (Nagel 2018)	0.2	0.3	1.6	-0.2	-0.3	-1.3	-0.4	-0.3	-0.2	0.3	1.0	1.1	0.1	-0.1	-0.3	0.5
Depression (Nagel 2018)	0.5	0.8	3.9	0.1	0.6	-0.1	0.0	-0.9	-0.2	-0.3	2.0	1.9	0.7	0.7	0.5	0.6
Intelligence (Savage-Jansen 2018)	1.2	3.7	6.4	-2.5	-2.2	-1.8	-1.8	-1.6	-2.2	0.9	-1.2	1.6	-2.0	-2.1	-2.1	-2.2
Neuroticism (Nagel 2018)	0.2	0.4	2.0	-0.3	-0.4	-1.0	-0.6	-0.7	-0.1	0.2	1.1	1.4	-0.2	-0.1	-0.4	0.4
Schizophrenia (2018)	0.1	0.1	0.3	0.5	0.2	-0.3	0.1	0.0	0.3	-0.1	0.6	0.4	0.3	0.2	0.2	0.5
Schizophrenia vs Biploar Disorder	1.9	2.5	5.6	1.8	1.7	1.8	1.9	2.1	1.8	0.0	0.8	-2.4	1.0	1.0	1.2	1.3
Worry (Nagel 2018)	0.1	0.1	0.5	0.3	0.2	-0.5	0.1	0.3	0.3	0.3	0.7	0.4	0.2	0.2	0.1	0.7
Alzheimer’s Disease (in mother)	1.1	1.3	3.4	1.0	1.1	0.7	-0.1	-0.6	0.9	-1.8	0.3	0.4	1.6	1.7	1.5	1.3
Alzheimer’s Disease (in father)	0.1	0.2	0.3	-0.4	-0.4	0.0	-0.1	-0.5	-0.2	0.1	0.5	0.4	-0.5	-0.4	-0.4	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.8	0.6	0.7	0.9	0.2	-0.6	0.6	-1.3	0.7	0.3	0.6	0.9	0.8	0.3
Crohns Disease (2017)	0.4	0.9	1.8	0.9	1.0	0.4	0.8	0.9	0.7	-0.5	1.0	-0.7	1.3	1.2	1.2	1.3
Irritable Bowel Disease (IBD)	0.3	0.7	2.5	0.6	0.6	-0.5	0.4	0.6	0.1	-0.6	0.2	-0.3	1.6	1.2	1.2	1.3
Ulcerative Colitis (UC)	0.4	0.7	2.8	0.6	0.5	-0.8	0.2	0.5	0.0	-0.7	-0.6	-0.2	1.7	1.2	1.2	1.3
Major Depression (MDD)	0.6	0.8	3.3	-0.4	-0.3	-0.3	-1.5	-1.6	-0.3	-0.9	0.8	1.8	-0.1	0.2	0.0	-0.1
Reaction Time	1.0	1.9	4.5	-1.5	-1.2	-1.8	-0.6	-0.5	-2.1	1.5	0.9	1.4	-1.1	-1.6	-1.6	-1.2
Verbal and Numeric Reasoning (VNR)	4.7	11.3	16.8	-4.1	-3.9	-3.3	-3.2	-2.6	-3.9	1.7	-2.1	3.0	-3.6	-3.7	-3.8	-3.9
Breast Cancer	0.1	0.3	1.3	0.2	0.1	-0.4	0.4	1.0	0.5	1.1	0.4	-0.2	0.1	-0.0	-0.1	0.7
Ovarian Cancer	0.2	0.2	1.2	-0.1	0.4	1.0	0.1	-0.2	-0.0	0.1	1.1	0.0	-0.3	0.0	0.1	-0.5
Prostate Cancer	0.4	0.6	1.5	-1.0	-0.3	-0.4	-0.1	-0.6	-1.0	0.7	1.2	1.0	-0.8	-0.7	-0.9	-0.6
Age at First Birth	0.6	0.8	2.5	-0.8	-0.4	-0.8	-1.3	-1.1	-1.0	-1.5	-1.6	0.4	0.4	0.2	0.2	-0.5
Bipolar Disorder (2011)	2.9	2.8	6.2	-1.8	-1.8	-1.7	-2.3	-2.4	-1.6	-0.6	-1.4	2.5	-0.9	-1.0	-1.1	-1.3
Body Mass Index (BMI) (2010)	0.2	0.3	2.7	-0.1	0.2	0.3	0.0	-0.7	0.1	0.3	1.6	0.9	-0.2	0.2	0.1	0.1
Coronary Artery Disease (CAD)	0.6	0.7	2.3	0.7	-0.1	-0.3	-1.1	-0.8	0.6	-1.5	-0.5	0.7	0.9	0.9	0.7	1.0
Crohns Disease (2012)	0.3	0.4	1.3	-0.2	-0.3	-1.1	-1.0	-0.7	-0.4	-0.8	-0.7	0.7	0.7	0.3	0.3	0.1
Mean Putamen Volume	1.1	1.3	2.5	1.2	1.3	1.5	0.4	0.1	0.9	-1.5	0.4	-1.1	1.3	1.5	1.6	0.8
Fasting Glucose	0.1	0.1	0.6	-0.1	0.0	0.8	-0.3	-0.2	-0.1	-0.3	-0.1	0.4	0.1	0.2	0.3	-0.2
HbA1C	0.2	0.2	0.6	0.6	-0.2	-0.2	0.4	-0.4	-0.4	0.1	0.2	0.3	0.8	0.5	0.6	0.2
HDL Cholesterol	0.1	0.2	1.1	0.2	0.1	0.0	0.4	1.0	0.3	-0.1	-0.3	-0.9	0.5	0.1	0.2	0.5
LDL Cholesterol	2.4	3.7	5.7	2.3	2.1	2.1	1.3	1.2	2.4	-1.6	0.4	-2.1	1.9	2.3	2.3	2.0
Lupus	1.5	2.2	3.9	-1.7	-1.4	-1.7	-1.8	-1.8	-1.9	-0.6	-1.7	2.0	-0.7	-0.8	-1.0	-1.2
Neuroticism (2016)	0.1	0.2	0.7	0.5	0.4	0.5	0.8	0.1	0.6	0.4	0.8	-0.2	-0.2	0.0	0.0	0.1
Primary Biliary Cirrhosis	0.2	0.3	1.8	0.2	-0.1	-0.5	-0.6	-0.4	0.5	0.1	1.3	1.2	0.1	0.0	-0.1	0.1
Rheumatoid Arthritis	0.7	0.9	3.0	-0.0	0.2	0.2	1.5	1.7	-0.1	1.4	1.3	-1.3	-0.5	-0.8	-0.5	-0.4
Schizophrenia (2014)	0.0	0.1	0.3	0.0	-0.3	-0.5	-0.2	-0.1	0.0	0.1	0.4	0.5	-0.1	-0.2	-0.2	0.0
Triglycerides	1.2	2.0	5.7	-1.7	-1.2	-0.9	-1.9	-2.2	-1.7	-0.1	-0.2	2.4	-0.8	-0.8	-0.9	-1.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	-0.9	-1.1	-1.1	-0.5	-0.4	-0.6	0.6	-1.2	0.7	-1.0	-1.1	-1.1	-0.7
Ulcerative Colitis	0.5	0.7	2.0	-0.1	-0.0	-0.9	-0.7	-0.8	-0.9	-1.4	-0.7	0.6	1.2	0.9	0.8	0.5
Blood Eosinophil Count	0.2	1.4	10.0	0.1	1.4	2.0	1.2	-0.2	0.1	0.7	3.2	0.2	-0.3	0.3	0.2	-0.2
Blood Platelet Count	0.5	5.7	13.6	2.2	2.4	2.2	3.7	3.7	2.6	2.1	2.9	-2.6	0.5	0.8	0.8	2.0
Blood Red Count	0.1	0.9	2.3	-1.1	-1.0	0.1	-0.6	-0.6	-0.6	0.2	-0.4	0.2	-1.5	-1.3	-1.2	-1.5
Blood White Count	3.5	25.6	51.0	5.8	6.1	3.9	4.7	3.3	5.4	-0.3	7.1	-1.6	5.2	5.7	5.2	6.8
Heel T-Score	0.9	7.2	15.4	-3.4	-2.6	-3.3	-1.1	-1.3	-3.9	2.5	0.4	2.5	-2.5	-3.1	-3.2	-2.6
BMI	0.5	3.1	7.0	1.5	2.1	2.5	0.2	-0.7	1.8	-1.8	2.6	0.5	1.5	2.2	1.9	1.6
Height	2.2	42.1	68.1	7.7	7.3	8.2	4.3	4.2	7.9	-5.4	1.1	-7.3	6.3	7.2	7.6	6.0
Waist Hip Ratio (WHR)	0.3	1.4	6.1	0.4	0.1	-0.3	1.7	2.0	0.6	2.5	1.0	-0.9	-0.8	-1.0	-0.9	0.3
Systolic Blood Pressure	0.3	1.6	5.0	1.2	1.3	1.8	1.4	1.6	1.2	-0.5	0.3	-2.2	0.8	0.9	1.2	0.5
Smoking Status	0.3	0.6	3.3	-0.2	0.6	1.0	0.6	-0.0	-0.1	1.4	1.8	0.5	-0.8	-0.4	-0.5	-0.3
Allergy or Eczema	0.1	0.4	2.4	0.3	-0.3	-1.5	-0.0	0.4	0.2	-0.3	0.5	0.2	0.7	0.3	0.2	0.9
Cardiovascular Disease	0.0	0.1	0.1	0.2	0.3	0.2	0.3	0.4	0.1	0.3	0.2	-0.3	0.1	0.1	0.1	0.2
Hypothyroidism (self reported)	0.4	0.9	4.9	0.2	0.7	1.2	1.2	0.5	0.3	1.6	2.2	0.2	-0.6	-0.2	-0.2	0.0
Respiratory disease	0.1	0.3	1.7	0.3	0.4	0.6	-0.3	-0.5	0.4	-0.1	1.3	0.9	0.2	0.5	0.3	0.3
Type 2 Diabetes (T2D) (2018)	3.1	5.8	9.5	2.7	3.0	2.1	1.5	1.4	2.2	-1.7	1.8	-1.4	3.0	3.1	3.0	3.0
Lung FEV1/FVC ratio	1.1	5.5	12.6	2.5	3.0	3.5	1.1	0.2	2.5	-2.0	2.8	-0.9	2.1	2.8	2.8	2.0
Lung FVC	2.7	13.5	27.9	-4.3	-4.1	-3.9	-4.2	-3.9	-5.3	-0.3	-4.0	3.1	-2.3	-3.0	-2.9	-4.1
Neuroticism	0.2	0.4	1.4	-0.4	-0.4	-0.8	-1.1	-0.9	-0.2	-0.3	0.4	1.2	-0.2	-0.1	-0.3	0.1
Chronotype (morning person)	0.2	0.4	2.0	0.5	0.6	1.0	0.9	0.3	0.1	0.6	1.4	-0.0	-0.1	0.2	0.2	-0.0
Hair Pigment	0.1	1.9	4.2	-1.6	-1.5	-1.6	-1.9	-1.7	-1.4	0.2	-0.4	2.1	-0.9	-1.0	-1.2	-1.1
Tanning	0.2	2.7	5.8	-1.9	-1.5	-1.6	-2.3	-2.4	-2.0	-0.9	-1.6	2.1	-0.6	-0.8	-0.9	-1.3
Hand grip strength (left)	0.7	1.7	6.2	1.0	1.1	2.0	-0.3	-0.4	1.1	-2.5	-1.2	-1.1	1.1	1.5	1.6	0.3
Number of treatments/medications taken	0.5	1.0	2.4	1.0	1.0	0.2	-0.1	0.2	0.5	-0.7	1.6	0.1	1.4	1.3	1.2	1.5
Average weekly spirits intake	1.6	2.0	3.3	1.8	1.5	1.2	1.7	1.5	1.6	-0.0	1.4	-1.4	1.1	1.3	1.3	1.7
Sensitivity / hurt feelings	0.3	0.6	2.4	0.7	0.9	0.9	0.6	0.0	0.9	-0.4	1.6	0.3	0.5	0.8	0.6	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.6	3.3	-0.1	0.2	-0.4	-0.5	-1.1	-0.1	-0.3	1.5	1.8	0.6	0.6	0.4	0.5
Hearing difficulty/problems: Yes	2.3	3.5	9.7	-2.1	-1.6	-1.1	-2.4	-2.9	-2.0	-0.1	0.1	3.1	-1.5	-1.3	-1.5	-1.9
Relative age of first facial hair	0.9	1.8	6.1	-0.6	-1.5	-2.5	-1.8	-1.4	-1.0	-1.2	-2.1	1.6	0.5	0.1	-0.1	0.1
Other serious medical condition/disability diagnosed by doctor	3.4	4.4	6.7	-2.6	-2.1	-1.7	-2.1	-2.0	-2.6	1.2	-0.6	2.4	-2.2	-2.2	-2.3	-2.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.4	-1.0	-0.8	-0.1	-0.9	-1.5	-1.0	-0.2	0.8	1.6	-1.0	-0.8	-0.8	-1.4
Ever had hysterectomy (womb removed)	1.5	1.7	3.1	-1.2	-1.8	-1.5	-1.2	-0.8	-1.2	1.0	-0.6	1.3	-1.4	-1.6	-1.5	-1.4
Systolic blood pressure, automated reading	0.4	1.3	2.3	1.1	1.1	1.3	0.4	0.4	1.5	-1.3	-0.0	-0.9	1.2	1.5	1.5	1.0
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.6	1.1	1.3	1.2	0.8	0.7	0.7	-0.3	1.3	-0.9	1.0	1.0	1.1	0.9
Angina	0.6	0.8	3.5	-0.6	-0.4	-0.5	-1.2	-1.8	-0.4	-0.8	0.8	1.9	-0.0	0.1	-0.1	-0.1
Medication for hormone replacement therapy	0.9	1.0	3.7	-0.2	-0.1	0.2	-1.8	-1.8	-0.5	-1.9	-0.5	1.1	0.6	0.7	0.7	-0.1
Vitamin and mineral supplements	0.2	0.2	0.8	-0.5	-0.3	-0.3	-0.3	-0.9	-0.5	-0.0	0.7	0.8	-0.2	-0.1	-0.2	-0.4
Supplements: Zinc	0.9	0.9	1.5	-1.2	-1.1	-0.7	-1.0	-0.4	-0.9	1.0	-0.6	0.7	-1.2	-1.2	-1.1	-1.1
Medication: Co-codamol	2.1	2.4	4.5	-1.9	-1.6	-1.0	-1.9	-2.0	-1.6	0.5	-0.2	2.1	-1.6	-1.4	-1.6	-1.7
Medication: Metformin	2.1	2.9	4.2	1.9	2.1	1.5	1.4	1.6	1.7	-0.8	1.5	-1.5	1.9	1.9	1.9	2.0
Diabetes (father)	0.3	0.3	0.8	0.4	0.6	0.3	0.2	0.7	-0.1	-0.7	-0.5	-0.9	0.9	0.5	0.7	0.3
Diabetes (mother)	0.1	0.1	0.6	-0.1	-0.1	0.1	0.0	0.2	0.1	0.8	0.2	0.2	-0.5	-0.3	-0.4	-0.0
Severe depression (siblings)	0.5	0.6	1.9	-0.6	-0.5	-1.4	-1.2	-0.7	-0.6	-0.7	-1.2	1.0	0.4	0.1	-0.1	0.2
Pack years adult smoking proportion	0.8	1.2	2.6	-1.1	-1.3	-1.6	-1.6	-1.2	-1.2	-0.1	-0.9	1.3	-0.5	-0.8	-0.8	-0.8
Impedance of leg (right)	0.5	2.6	4.0	2.0	1.8	1.3	1.7	1.8	1.5	-0.6	0.9	-2.0	1.6	1.5	1.7	1.7
Leg fat-free mass (left)	1.8	9.7	19.3	3.5	3.6	4.4	1.2	0.8	3.9	-3.2	1.2	-2.2	3.0	3.9	3.8	2.9
Trunk fat percentage	2.0	8.0	14.7	3.1	3.4	3.8	0.9	-0.0	3.3	-2.6	3.0	-0.7	2.8	3.6	3.4	2.8
Hand grip strength (right)	0.4	1.1	5.1	0.7	0.5	1.5	-0.7	-0.9	0.7	-2.3	-0.9	-0.4	0.7	1.1	1.2	-0.1
Townsend deprivation index at recruitment	0.2	0.3	2.9	0.1	0.3	0.1	0.2	-0.2	0.1	0.6	1.7	0.9	0.1	0.1	0.0	0.4
Current tobacco smoking	0.2	0.4	1.5	-0.3	0.6	0.5	1.1	0.8	-0.4	1.2	0.6	-0.6	-0.3	-0.4	-0.3	-0.2
Average weekly fortified wine intake	1.7	2.0	3.5	-1.9	-1.4	-1.0	-1.3	-1.6	-1.7	0.6	0.4	1.7	-1.4	-1.4	-1.5	-1.7
Maternal smoking around birth	0.8	1.2	6.2	0.9	1.2	1.7	0.2	-0.5	1.3	0.0	2.5	0.7	0.3	1.0	0.7	0.8
Fed-up feelings	0.3	0.5	1.8	-0.3	-0.4	-1.3	0.3	0.3	-0.2	1.0	1.2	0.8	-0.3	-0.5	-0.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	9.5	0.4	0.7	0.2	1.1	-0.0	0.3	0.9	3.1	1.4	0.1	0.3	0.1	0.8
Relative age voice broke	0.3	0.5	1.2	-0.5	-1.1	-1.0	-0.5	-0.7	-0.4	0.2	-0.8	1.0	-0.6	-0.6	-0.7	-0.4
Taking other prescription medications	0.6	1.0	4.9	-0.5	-0.6	-2.2	-0.5	-0.0	-1.1	1.0	1.3	1.6	0.4	-0.3	-0.4	0.6
Age when periods started (menarche)	0.1	0.3	2.0	-0.2	-0.3	-0.6	-0.1	0.4	-0.4	-0.2	-1.4	-0.8	-0.0	-0.4	-0.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	-0.7	-0.7	-0.2	-1.2	-1.2	-1.4	-0.7	0.1	1.2	-0.6	-0.6	-0.5	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	-0.9	-0.9	-0.7	-0.7	-0.5	-1.4	0.3	-0.4	0.4	-0.8	-1.0	-0.9	-1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.6	0.1	-0.0	-0.2	0.3	0.9	-0.1	-0.1	0.1	0.3	0.4	0.3	0.8
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.5	0.3	0.3	0.6	0.6	0.5	-0.1	0.4	-0.5	0.2	0.2	0.2	0.3
Serious illness, injury or assault to yourself	0.6	0.7	3.2	-0.9	-0.5	-0.2	-1.8	-1.2	-0.9	-0.2	0.5	1.1	-0.4	-0.4	-0.4	-0.7
High blood pressure	0.1	0.3	1.0	0.4	0.4	-0.0	-0.5	0.1	0.1	-0.6	-0.5	-0.2	1.0	0.8	0.8	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.3	0.7	0.2	-0.8	0.7	1.0	0.7	0.1	0.7	-0.4	0.7	0.4	0.4	1.1
Multivitamins +/- minerals	0.3	0.3	1.0	-0.4	-0.8	-0.8	-0.3	0.2	-0.3	0.5	-1.0	0.2	-0.6	-0.7	-0.7	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.4	0.4	0.3	0.3	0.7	0.6	-0.1	0.2	-0.6	0.0	0.1	0.1	0.3
Supplements: Glucosamine	0.7	0.9	2.9	0.8	0.7	1.0	0.1	0.4	0.6	-1.4	-1.7	-1.4	0.7	0.7	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.1	0.2	-0.1	0.4	0.3	-0.0	0.3	0.3	-0.1	-0.0	-0.0	-0.1	0.3
Medication: Atenolol	0.3	0.3	0.9	0.8	0.1	-0.2	-0.2	0.0	0.9	-0.4	-0.7	0.1	0.6	0.7	0.6	1.0
Medication: Levothyroxine sodium	0.5	0.8	2.1	0.9	0.5	1.2	1.0	1.5	1.3	1.2	0.6	-1.1	-0.6	-0.2	-0.2	0.3
Sitting height	1.0	6.8	16.9	2.6	3.1	4.1	0.7	0.3	2.6	-3.4	0.8	-2.3	2.5	3.2	3.3	1.9
Chronic bronchitis/emphysema (father)	2.0	2.4	4.8	-1.7	-1.9	-2.2	-1.2	-0.9	-1.6	1.0	-1.4	1.6	-1.3	-1.6	-1.7	-1.4
High blood pressure (mother)	0.4	0.6	1.9	0.5	0.5	0.2	-0.4	0.6	0.4	-0.9	-1.2	-1.4	0.9	0.7	0.8	0.6
Body mass index (BMI)	0.3	1.1	2.4	0.9	1.2	1.6	-0.1	-0.6	1.2	-1.3	1.3	0.3	0.9	1.4	1.2	0.9
Impedance of leg (left)	0.4	2.1	5.0	1.6	1.5	1.2	2.1	2.2	1.3	0.5	1.4	-2.1	0.8	0.7	0.9	1.2
Leg predicted mass (left)	1.9	9.9	20.0	3.5	3.7	4.5	1.3	0.8	4.0	-3.2	1.2	-2.3	3.0	3.9	3.8	3.0
Trunk fat mass	2.6	11.1	20.5	3.8	4.0	4.5	1.5	0.7	4.1	-2.9	2.9	-1.6	3.2	4.1	4.0	3.3
Waist circumference	1.4	5.2	9.9	2.7	2.8	2.9	1.9	1.4	3.1	-0.9	2.1	-1.6	1.9	2.4	2.3	2.5
Number of incorrect matches in round	0.0	0.1	0.3	0.2	0.3	0.5	0.1	-0.2	0.2	-0.5	0.1	0.1	0.3	0.3	0.3	0.1
Past tobacco smoking	0.6	1.1	2.3	1.2	0.6	0.6	0.7	1.1	1.2	-0.9	-1.2	-1.5	1.1	0.9	1.0	1.0
Alcohol usually taken with meals	2.5	4.1	11.0	-2.1	-2.4	-2.1	-2.7	-2.1	-2.0	-1.0	-3.3	1.6	-1.0	-1.3	-1.3	-1.9
Nervous feelings	0.1	0.2	0.6	-0.4	-0.2	-0.4	-0.0	-0.3	-0.0	0.6	0.6	0.8	-0.4	-0.3	-0.4	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	5.8	-0.9	-0.8	-0.7	-1.3	-1.8	-1.1	0.5	1.8	2.4	-0.8	-0.6	-0.8	-0.8
Hearing difficulty/problems with background noise	1.2	1.9	8.7	-1.4	-0.8	-0.8	-1.3	-2.0	-1.1	0.5	1.6	3.0	-1.0	-0.7	-1.1	-0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.0	0.1	-0.2	-0.4	-0.2	0.1	-0.7	0.1	0.1	0.3	0.3	0.2	0.2
Had menopause	0.8	0.9	3.2	-0.6	-0.9	-1.7	0.5	0.3	-0.3	1.8	0.6	1.0	-0.9	-1.0	-1.2	-0.0
Had other major operations	0.5	0.6	1.4	-0.9	-0.6	-0.9	-1.0	-1.2	-0.9	-0.6	-0.2	1.2	-0.1	-0.2	-0.3	-0.4
Forced vital capacity (FVC)	0.9	3.4	10.8	1.7	1.7	2.0	-0.4	-0.5	1.3	-3.3	-0.9	-1.1	2.3	2.5	2.5	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.2	-1.2	-0.9	-1.0	-0.6	-0.6	-1.5	0.6	-0.2	0.8	-0.7	-1.0	-1.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.9	0.3	-0.1	-0.4	-0.2	-0.5	0.9	-0.2	0.5	0.7	0.3	0.4	0.2	0.8
Qualifications: None of the above	1.8	3.9	9.4	1.9	1.8	1.2	3.0	3.0	2.1	2.0	3.1	-1.6	0.4	0.5	0.5	1.8
Financial difficulties in last 2 years	0.7	1.0	4.3	-0.4	0.5	1.1	-0.2	-1.8	-0.3	-0.4	2.1	1.8	-0.4	0.2	-0.1	-0.3
Mouth/teeth dental problems	1.7	2.6	4.2	2.0	1.4	0.9	1.7	1.8	1.7	-1.3	0.1	-1.7	1.9	1.7	1.8	1.9
Heart attack	0.3	0.4	2.0	-0.3	-0.3	-0.4	-0.4	-0.7	-0.2	0.2	1.4	1.3	-0.3	-0.2	-0.4	0.0
Allergy	0.1	0.2	1.2	0.1	0.4	1.1	-0.0	-0.5	0.0	-0.5	-0.3	-0.0	0.1	0.3	0.4	-0.2
Pain all over the body in last month	0.4	0.4	1.3	0.7	0.7	0.3	0.4	1.1	0.7	-0.1	0.2	-1.0	0.7	0.5	0.6	0.8
Diabetes (self-reported)	1.0	1.5	4.3	1.2	1.5	1.3	1.0	0.6	1.1	-0.4	2.1	-0.1	1.2	1.3	1.2	1.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.7	-0.9	-1.1	-0.7	-0.5	-0.7	-0.2	0.1	0.6	-0.2	-0.5	-0.5	-0.6
Medication: Ramipril	2.1	2.7	6.2	2.1	1.7	0.6	0.1	0.6	1.6	-1.1	1.4	-0.2	2.3	2.3	2.0	2.5
Medication: Simvastatin	2.9	4.3	7.9	2.5	2.1	1.1	1.4	1.4	2.1	-1.6	0.7	-1.7	2.8	2.6	2.6	2.7
Fluid intelligence score	2.5	5.3	7.9	-2.7	-2.6	-2.7	-2.8	-2.3	-2.8	0.2	-2.2	2.3	-1.7	-1.9	-2.0	-2.2
Illnesses of siblings	0.1	0.2	1.1	0.1	0.0	0.1	0.4	-0.0	0.3	0.5	1.0	0.5	-0.4	-0.2	-0.3	0.1
Neuroticism score	0.2	0.5	1.5	-0.3	-0.2	-0.4	-1.2	-1.2	-0.2	-0.8	0.8	1.2	0.2	0.3	0.1	0.0
Weight	2.2	10.7	20.2	3.7	3.9	4.5	1.6	1.1	4.2	-3.0	1.9	-2.3	3.1	4.0	3.9	3.2
Impedance of arm (right)	0.9	4.1	8.2	2.2	2.2	2.2	0.4	-0.5	1.6	-2.5	1.8	-0.0	2.6	2.9	2.8	2.0
Arm fat percentage (right)	1.2	4.6	8.1	2.1	2.4	2.8	0.2	-0.8	2.3	-2.4	2.4	0.2	2.1	2.9	2.6	2.0
Trunk fat-free mass	1.4	7.8	13.5	3.2	3.1	3.5	1.8	2.1	3.7	-2.3	-0.1	-3.4	2.5	3.0	3.0	2.6
Hip circumference	1.8	7.9	13.5	3.1	3.2	3.7	1.0	0.5	3.6	-2.9	1.6	-1.5	2.9	3.6	3.5	3.0
Time employed in main current job	1.3	1.5	7.3	0.5	0.1	-0.6	1.5	2.7	0.6	2.2	0.2	-1.7	-0.4	-0.8	-0.7	0.5
Alcohol intake versus 10 years previously	1.2	1.8	3.2	-1.4	-1.4	-1.0	-1.6	-1.6	-1.8	0.3	-0.4	1.8	-1.2	-1.2	-1.3	-1.5
Father’s age at death	0.5	0.7	3.3	0.4	0.1	0.4	1.5	1.2	0.8	1.8	0.3	-0.8	-0.7	-0.4	-0.4	0.2
Worrier / anxious feelings	0.5	0.9	2.3	0.2	0.4	-0.2	-1.0	-1.1	-0.1	-1.5	1.1	1.3	1.2	1.2	0.9	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	8.7	0.6	1.1	1.2	0.8	0.1	1.0	0.4	3.0	0.9	0.3	0.7	0.5	0.9
Falls in the last year	0.3	0.4	1.7	-0.2	0.0	-0.2	-0.7	-0.7	-0.1	0.0	1.3	1.3	0.0	0.2	-0.0	0.3
Hair/balding pattern: Pattern 3	3.0	4.5	7.8	2.4	2.4	2.4	2.1	1.6	2.0	-1.6	0.5	-2.8	2.3	2.3	2.5	1.9
Number of live births	1.8	2.5	7.1	1.3	1.8	1.2	2.5	1.8	1.6	1.2	2.7	-1.2	0.7	0.8	0.8	1.5
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	15.8	2.1	2.0	2.2	-0.6	-0.6	1.7	-4.0	-0.8	-1.1	2.9	3.1	3.1	1.9
Pulse rate	2.4	4.0	7.2	2.4	2.0	1.6	2.3	2.5	2.7	0.1	1.6	-2.2	1.6	1.6	1.7	2.2
Happiness	4.7	5.7	9.5	-2.9	-2.7	-2.7	-1.3	-0.9	-2.4	2.4	-0.4	1.9	-2.8	-3.1	-3.1	-2.5
Noisy workplace	0.6	0.8	3.6	-0.2	-0.0	0.0	0.9	0.8	0.1	1.9	1.3	0.3	-1.1	-0.9	-1.0	-0.2
Qualifications: A levels/AS levels or equivalent	1.0	2.2	5.6	-1.4	-2.0	-2.3	-2.2	-1.1	-1.3	-0.7	-2.4	0.9	-0.5	-1.0	-1.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	5.2	6.0	10.6	-3.1	-2.4	-2.1	-1.3	-1.9	-3.2	1.7	0.3	2.7	-2.6	-2.8	-2.8	-2.9
Mouth/teeth dental problems: Dentures	5.5	9.2	14.8	-3.8	-3.2	-2.5	-2.3	-2.2	-3.6	2.4	-0.6	2.3	-3.5	-3.7	-3.7	-3.9
Asthma	0.2	0.3	1.3	-0.4	-0.5	-1.0	-0.9	-0.7	-0.5	0.1	-0.0	1.1	-0.0	-0.2	-0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.2	-0.7	-0.2	-0.1	-1.6	-1.8	-1.0	-1.2	0.5	1.5	0.1	0.2	0.1	-0.4
Medication: Cholesterol lowering	0.1	0.1	0.8	-0.2	-0.1	-0.9	-0.2	0.1	-0.0	0.4	0.2	0.6	0.1	-0.1	-0.2	0.5
Depression (self-reported)	1.0	1.2	2.1	-1.2	-1.1	-1.3	-0.3	-0.6	-1.0	1.4	0.6	1.4	-1.2	-1.2	-1.3	-0.7
Medication: Lansoprazole	0.8	0.9	2.3	1.0	0.8	0.4	1.4	1.5	1.1	1.1	0.7	-1.3	0.4	0.2	0.3	1.0
Prospective memory result	1.9	2.4	8.3	1.1	1.3	1.6	2.6	1.8	1.5	1.7	2.9	-0.9	-0.6	-0.1	-0.1	0.6
Lung cancer (father)	0.3	0.3	1.6	0.5	0.4	1.3	0.0	-0.3	1.2	-0.5	0.7	-0.2	-0.1	0.4	0.4	0.1
Illnesses of mother	0.3	0.4	0.8	0.7	0.7	0.6	0.7	0.4	0.5	-0.9	0.3	-0.5	0.8	0.7	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.8	0.8	0.8	1.4	-0.8	-0.9	0.5	-2.2	-0.2	-0.3	1.1	1.3	1.4	0.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.9	-0.1	-0.0	0.4	-0.8	-0.5	-0.1	-1.0	-0.4	0.1	0.2	0.3	0.3	-0.3
Impedance of arm (left)	0.6	2.7	5.5	1.8	1.7	1.6	0.3	-0.5	1.4	-1.8	1.7	0.1	2.1	2.4	2.3	1.8
Arm fat mass (right)	1.5	6.3	12.2	2.7	3.0	3.5	0.7	-0.1	3.1	-2.6	2.2	-0.7	2.5	3.2	3.1	2.4
Trunk predicted mass	1.3	7.6	13.4	3.1	3.0	3.5	1.8	2.1	3.7	-2.2	-0.1	-3.4	2.4	2.9	3.0	2.6
Standing height	2.6	25.7	41.2	6.0	5.8	6.4	3.2	3.2	6.3	-4.2	1.1	-5.4	4.9	5.7	5.9	4.9
Length of working week for main job	2.2	2.4	5.0	-1.9	-1.6	-1.2	-2.0	-2.2	-2.0	-0.7	-1.7	1.7	-0.7	-0.8	-0.8	-1.6
Exposure to tobacco smoke at home	0.5	0.5	1.5	1.0	0.5	-0.2	0.5	0.2	0.8	-0.3	0.7	0.1	1.1	0.9	0.9	1.2
Breastfed as a baby	3.2	4.0	6.8	-2.0	-2.6	-2.3	-1.0	-1.3	-1.6	1.7	-1.5	2.0	-2.4	-2.4	-2.4	-2.0
Tense / ‘highly strung’	0.1	0.2	0.5	0.2	0.4	0.1	-0.5	-0.6	0.0	-0.6	0.3	0.4	0.7	0.7	0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	-0.6	-0.3	-1.2	-0.4	-0.5	-0.6	1.3	1.0	1.1	-0.2	-0.4	-0.5	0.1
Hair/balding pattern: Pattern 4	3.7	9.0	16.6	-3.2	-3.2	-2.6	-1.1	-1.2	-2.2	3.9	0.8	3.2	-4.1	-3.9	-4.1	-2.8
Birth weight of first child	1.9	3.4	8.5	1.8	1.6	1.5	-0.3	-0.5	1.6	-2.9	-1.0	-0.4	2.5	2.6	2.6	1.8
Peak expiratory flow (PEF)	0.3	0.8	4.0	0.1	-0.0	0.5	-1.3	-1.2	0.0	-2.0	-1.1	0.0	0.6	0.7	0.8	-0.2
Pulse wave reflection index	0.8	1.0	3.0	-0.8	0.2	1.0	-1.3	-1.7	-1.3	-1.5	-0.8	0.6	-0.0	0.2	0.2	-1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.4	1.1	1.6	1.6	-0.2	-0.9	0.9	-1.8	1.4	-0.0	1.5	1.8	1.8	1.1
Loud music exposure frequency	0.7	0.8	1.5	-0.9	-0.6	-0.4	0.2	-0.2	-0.8	1.2	0.6	0.7	-1.2	-1.2	-1.2	-1.0
Qualifications: O levels/GCSEs or equivalent	2.0	3.3	7.3	-1.9	-2.5	-2.7	-2.1	-1.4	-1.7	-0.5	-2.7	1.2	-1.0	-1.4	-1.4	-1.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.1	0.6	0.7	0.6	-1.2	-1.4	0.8	-2.0	-0.5	1.0	1.4	1.6	1.4	1.0
Blood clot in the leg (DVT)	1.5	1.9	4.3	-1.3	-1.2	-0.4	0.1	0.6	-0.8	1.9	-1.2	-0.6	-2.1	-2.0	-1.8	-1.9
Medication: Paracetamol	0.3	0.5	1.5	0.1	0.8	-0.0	-0.5	-0.2	-0.8	-0.9	0.9	0.0	1.2	0.9	0.9	0.5
Headache pain in last month	0.4	0.7	2.7	-0.6	-0.3	0.1	-1.7	-1.6	-0.6	-1.4	0.0	0.8	-0.0	0.2	0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2	-0.1	-0.2	-0.2	0.2	-0.2	-0.1	-0.1	-0.0	-0.4
Glaucoma (self-reported)	0.1	0.2	0.7	-0.2	0.1	-0.2	0.9	0.4	-0.4	0.8	0.4	-0.2	-0.1	-0.2	-0.1	-0.0
Gout (self-reported)	0.2	0.3	0.9	0.0	-0.2	-1.0	-0.7	-0.4	-0.1	-0.6	0.0	0.7	0.7	0.4	0.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.0	0.2	0.4	0.8	0.9	0.7	0.3	1.3	1.4	-0.1	-0.6	-0.3	-0.3	-0.1
Medication: Amlodipine	0.1	0.1	0.3	0.1	0.4	0.2	0.5	0.6	0.3	0.4	0.2	-0.4	0.1	0.1	0.0	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.4	1.0	0.3	-0.1	0.4	0.5	1.6	-0.2	0.3	0.0	0.6	0.7	0.6	1.3
Birth weight	2.5	5.3	12.7	2.5	2.3	2.1	0.4	-0.1	2.0	-3.6	0.1	-1.0	3.0	3.3	3.2	2.3
Chronic bronchitis/emphysema (mother)	2.4	2.8	5.6	2.1	1.9	1.4	1.3	1.1	2.4	-0.6	1.4	-0.9	1.7	1.9	1.8	2.2
High blood pressure (siblings)	0.1	0.2	1.4	0.1	0.2	0.3	0.4	0.8	0.0	0.2	-0.4	-1.2	0.1	-0.1	0.1	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.9	4.7	0.1	0.1	0.6	-1.3	-1.4	-0.3	-2.2	-0.9	0.2	0.7	0.8	0.9	-0.3
Body fat percentage	1.7	6.5	12.2	2.9	3.1	3.5	1.1	0.3	3.1	-2.1	2.8	-0.8	2.4	3.1	3.0	2.5
Leg fat percentage (right)	0.9	3.4	6.0	2.1	2.3	2.4	1.2	0.6	2.2	-1.1	2.3	-0.7	1.6	2.1	2.0	1.9
Arm fat-free mass (right)	1.4	6.9	13.3	3.0	3.0	3.4	2.2	2.4	3.6	-1.4	0.7	-3.2	2.0	2.5	2.6	2.5
Exposure to tobacco smoke outside home	0.4	0.5	1.6	0.8	0.6	0.0	1.2	1.3	0.6	0.6	0.4	-0.7	0.5	0.3	0.3	0.9
Comparative body size at age 10	0.5	1.4	4.9	1.2	0.2	0.2	1.6	2.2	1.8	1.2	0.3	-1.7	-0.1	-0.1	-0.1	1.0
Number of full brothers	1.4	1.7	3.1	-1.6	-1.4	-1.1	-1.2	-1.3	-1.7	0.3	-1.1	0.8	-1.3	-1.4	-1.3	-1.8
Worry too long after embarrassment	0.3	0.5	1.2	0.1	0.2	0.5	-1.1	-1.1	0.3	-1.0	0.8	0.8	0.3	0.6	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	4.0	-0.6	-0.3	-0.7	-1.5	-1.4	-0.4	-0.1	0.7	2.0	0.2	0.3	0.0	0.3
Wheeze or whistling in the chest in last year	0.6	1.1	2.9	-0.9	-0.8	-1.0	-0.5	-0.1	-0.6	1.7	1.3	1.2	-1.3	-1.2	-1.3	-0.6
Number of children fathered	1.8	2.0	5.1	-1.3	-1.7	-1.7	-2.2	-1.8	-1.4	-0.8	-1.8	1.4	-0.4	-0.7	-0.7	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.0	-0.0	-0.1	-0.3	-0.1	0.1	0.6	0.6	0.5	-0.1	-0.1	-0.1	0.2
Age at first live birth	0.9	1.6	2.9	-1.3	-1.7	-1.7	-0.8	-0.7	-1.2	1.0	-0.9	1.3	-1.4	-1.5	-1.6	-1.1
Pulse wave peak to peak time	0.2	0.2	0.7	0.3	0.2	-0.1	0.8	0.6	0.3	0.8	0.3	-0.4	-0.1	-0.1	-0.1	0.4
Health satisfaction	1.5	1.9	5.7	1.6	1.4	1.1	0.6	0.7	1.8	-0.4	2.4	-0.3	1.3	1.5	1.3	1.8
Shortness of breath walking on level ground	3.3	4.0	13.1	2.2	2.5	2.7	1.9	0.9	2.2	0.1	3.6	-0.6	1.2	1.8	1.7	1.9
Qualifications: College or University degree	0.6	2.0	5.2	-1.6	-1.5	-0.9	-2.3	-2.0	-1.3	-1.0	-1.7	1.3	-0.8	-0.7	-0.8	-1.5
Eye problems/disorders: None of the above	1.2	1.4	3.2	-0.9	-1.3	-0.9	-0.2	0.4	-0.5	1.6	-0.9	-0.1	-1.8	-1.8	-1.7	-1.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.1	-1.3	-1.0	-0.3	-0.3	0.2	-0.6	1.8	-0.2	0.0	-1.8	-1.7	-1.5	-1.4
Emphysema/chronic bronchitis	1.0	1.2	4.7	1.1	1.1	1.1	1.3	1.4	1.2	0.8	2.2	-0.8	0.0	0.3	0.3	0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	1.9	0.4	0.0	1.3	1.0	0.8	1.1	0.1	-1.3	-1.4	-0.7	-0.3	-0.2	-0.3
Neck or shoulder pain in last month	0.3	0.5	1.4	-0.4	0.2	0.4	-0.9	-1.2	-0.7	-1.0	0.8	1.0	0.2	0.3	0.3	-0.3
Medication: Blood pressure	0.2	0.4	1.3	0.5	0.3	-0.0	-0.5	0.2	0.3	-0.5	-1.1	-0.4	0.9	0.7	0.7	0.7
Angina (self-reported)	0.6	0.8	3.5	-0.6	-0.4	-0.6	-1.2	-1.8	-0.4	-0.8	0.7	1.9	-0.0	0.1	-0.1	-0.0
Migraine (self-reported)	4.0	4.9	8.8	-2.6	-2.4	-2.3	-2.9	-2.8	-2.8	-0.5	-1.5	3.0	-1.3	-1.5	-1.7	-2.0
Medication: Ibuprofen	0.6	0.7	2.3	-0.3	0.1	-0.0	-1.1	-1.4	-0.4	-1.1	1.5	1.5	0.3	0.5	0.3	0.1
Medication: Allopurinol	0.6	0.8	2.3	0.9	0.6	-0.1	-0.3	-0.2	0.9	-1.3	-0.0	0.2	1.4	1.3	1.1	1.5
Medication: Omeprazole	2.0	2.4	5.7	1.8	0.9	-0.2	-0.1	0.1	1.7	-2.0	-0.4	-0.4	2.4	2.2	2.1	2.2
Medication: Seretide 50 evohaler	0.9	1.0	3.1	1.2	0.8	0.6	1.0	1.6	1.8	0.6	0.5	-1.3	0.1	0.4	0.3	1.1
Mean time to correctly identify matches	1.3	2.5	5.8	-1.6	-1.4	-2.0	-0.1	0.1	-2.1	2.4	0.9	1.2	-1.4	-2.0	-2.0	-1.3
Heart disease (mother)	1.1	1.4	2.2	-1.3	-1.4	-1.4	-1.5	-0.8	-1.3	0.9	-0.2	0.8	-1.2	-1.3	-1.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.2	0.0	0.4	0.6	0.6	0.6	0.8	-0.1	-0.5	-0.5	-0.3	-0.3	-0.1
Whole body fat mass	2.4	10.2	19.3	3.6	3.8	4.4	1.5	0.7	4.0	-2.8	2.6	-1.7	3.0	3.9	3.8	3.2
Leg fat mass (right)	1.9	7.2	14.6	3.1	3.3	3.8	1.6	0.9	3.5	-2.0	2.3	-1.5	2.3	3.1	3.0	2.6
Arm predicted mass (right)	1.5	7.4	14.1	3.1	3.1	3.6	2.4	2.4	3.8	-1.4	0.9	-3.3	2.0	2.6	2.7	2.5
Pulse rate, automated reading	1.3	4.1	6.7	2.5	2.4	1.9	1.8	2.1	2.6	-0.4	1.5	-1.8	1.9	2.1	2.0	2.5
Alcohol intake frequency.	1.0	2.3	4.7	-1.8	-1.4	-0.7	-1.5	-2.2	-1.8	0.4	-0.8	1.8	-1.4	-1.3	-1.4	-1.9
Comparative height size at age 10	2.8	15.2	23.4	4.7	4.3	4.8	3.1	3.2	4.8	-2.7	0.5	-4.7	3.6	4.1	4.3	3.7
Number of full sisters	0.2	0.2	1.3	-0.2	-0.0	-0.7	0.5	-0.0	-0.5	0.4	1.1	0.5	0.1	-0.1	-0.2	0.1
Suffer from ‘nerves’	0.5	0.8	2.2	0.8	0.4	-0.3	1.3	1.4	0.6	1.5	1.4	-0.5	0.2	0.1	0.1	1.0
Overall health rating	2.2	4.6	11.2	2.4	2.7	2.1	1.7	1.4	2.5	-0.3	3.3	-0.9	2.0	2.2	2.0	2.6
Chest pain or discomfort	0.2	0.3	1.4	-0.4	-0.3	-0.8	-1.2	-0.5	0.0	0.4	0.4	0.9	-0.1	-0.0	-0.3	0.3
Had major operations	1.4	1.6	4.9	0.9	1.2	2.1	1.6	1.4	1.3	1.2	2.2	-1.3	-0.5	0.0	0.1	0.3
Age at last live birth	0.6	0.9	1.7	-1.0	-0.9	-0.7	-0.4	-0.6	-0.7	1.2	0.4	1.3	-1.2	-1.1	-1.2	-0.9
Family relationship satisfaction	1.9	2.4	4.0	-1.8	-1.6	-1.5	-1.3	-1.2	-1.7	1.1	0.4	2.0	-1.6	-1.7	-1.8	-1.6
Leg pain on walking	2.8	3.5	5.1	2.3	2.0	1.5	1.1	1.7	2.2	-1.2	0.5	-2.1	2.2	2.0	2.1	2.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.0	1.9	1.4	1.1	0.8	1.4	1.6	-1.0	-0.8	-2.0	1.8	1.7	1.8	1.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	0.7	0.6	0.6	0.5	0.6	0.6	-0.6	0.1	-0.8	0.8	0.8	0.9	0.6
Illness, injury, bereavement, stress in last 2 years	5.8	7.0	12.5	3.4	2.5	2.1	2.5	3.2	3.5	-0.6	0.5	-3.4	2.4	2.5	2.6	3.1
Medication: Aspirin	1.1	1.4	4.1	-1.0	-1.3	-2.0	-1.0	-0.8	-1.0	1.0	0.8	2.0	-0.8	-1.0	-1.2	-0.5
Supplements: Vitamin C	0.7	0.8	3.1	-0.2	-0.3	-0.6	-1.2	-1.1	-0.5	-1.4	-1.8	0.7	0.9	0.6	0.6	0.2
Knee pain experienced in last month	2.1	3.3	6.4	1.9	1.6	1.1	0.6	0.8	2.0	-2.3	-0.4	-1.2	2.5	2.4	2.3	2.3
Hypertension (Self-reported)	0.2	0.6	1.9	0.7	0.7	0.2	-0.1	0.5	0.3	-0.8	-0.5	-0.7	1.4	1.1	1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.4	0.4	0.2	-1.0	-0.1	0.1	0.1	-0.5	0.0	-0.1	1.2	0.7	0.7	1.0
Illnesses of father: Heart disease	1.3	1.8	4.5	-1.6	-1.8	-2.1	-1.4	-0.8	-1.6	0.6	-0.6	1.4	-0.9	-1.3	-1.3	-1.1
Illnesses of siblings: Diabetes	0.8	0.9	1.8	1.0	1.0	1.1	0.2	0.1	1.0	-1.3	0.4	-0.5	1.1	1.3	1.3	1.0
Smoking status: Previous	0.3	0.4	3.8	-0.0	0.3	0.5	0.0	-0.3	0.2	0.6	1.9	0.8	-0.4	-0.1	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.7	2.0	2.2	3.1	0.9	0.9	2.2	-1.4	1.3	-1.9	1.3	1.8	2.0	1.2
Whole body fat-free mass	1.5	8.5	15.4	3.3	3.4	3.9	1.7	1.7	3.8	-2.6	0.5	-3.0	2.7	3.3	3.3	2.8
Leg fat-free mass (right)	1.4	7.6	16.7	3.0	3.3	4.1	1.2	0.8	3.6	-2.7	1.1	-2.1	2.5	3.3	3.2	2.5
Arm fat percentage (left)	1.0	4.1	7.1	2.1	2.3	2.7	0.4	-0.5	2.3	-2.0	2.4	0.2	2.0	2.6	2.4	2.0
Average weekly red wine intake	0.7	1.0	4.4	0.7	1.2	2.1	0.6	-0.2	1.2	-0.7	1.6	-0.5	0.2	0.8	0.9	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.1	-0.2	-0.4	0.2	0.9	0.4	0.8	-0.9	-0.6	-0.2	-0.3	-0.3	0.2
Mood swings	0.5	0.8	3.0	0.1	0.2	-0.6	-1.1	-1.0	-0.4	-1.7	0.8	0.9	1.2	1.0	0.9	0.6
Loneliness, isolation	1.2	1.6	2.5	-1.3	-1.3	-1.2	-1.0	-1.0	-1.2	1.1	0.9	1.6	-1.5	-1.4	-1.6	-1.2
Long-standing illness, disability or infirmity	1.2	1.8	4.9	-1.3	-1.0	-1.0	-1.2	-1.2	-1.3	1.1	1.6	2.2	-1.2	-1.2	-1.4	-0.9
Ever had bowel cancer screening	0.5	0.6	2.0	-0.1	-0.1	-0.4	0.9	1.1	-0.1	1.4	1.1	-0.3	-0.7	-0.9	-0.8	-0.2
Diabetes diagnosed by doctor	2.2	3.7	6.2	2.1	2.5	1.8	1.8	1.5	1.7	-0.6	2.3	-1.1	2.1	2.1	2.1	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.5	-0.0	0.1	0.9	-0.9	-1.3	0.3	-1.6	-0.8	0.6	0.2	0.6	0.5	-0.2
Friendships satisfaction	3.0	3.7	7.7	-2.1	-2.1	-2.3	-0.6	-0.2	-1.6	2.8	-0.0	1.4	-2.4	-2.5	-2.6	-1.6
Qualifications: nursing, teaching	3.9	6.1	9.6	-2.7	-2.8	-2.3	-3.1	-2.9	-2.5	0.0	-2.3	3.0	-2.1	-2.0	-2.2	-2.4
Commuting to job workplace: Walk	0.4	0.4	0.9	-0.6	-0.7	-0.8	-0.9	-0.9	-0.6	-0.1	-0.5	1.0	-0.4	-0.4	-0.6	-0.3
Eye problems/disorders: Cataract	4.0	4.6	10.1	2.1	2.5	1.5	0.8	0.5	1.4	-2.8	0.5	-1.2	3.2	3.0	3.0	2.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.6	0.2	0.4	1.3	0.5	0.2	0.4	0.7	0.3	-0.7	-0.7	-0.3	-0.2	-0.5
Medication for cholesterol	0.2	0.4	0.7	-0.7	-0.6	-0.4	-0.2	-0.5	-0.5	0.3	-0.2	0.5	-0.8	-0.8	-0.8	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	9.9	-0.2	-0.1	-0.7	2.3	1.7	-0.3	3.1	1.9	-0.2	-0.9	-1.2	-1.1	-0.1
Back pain experienced in last month	0.4	0.6	2.0	0.1	1.0	0.3	-0.3	-0.5	-0.1	-0.6	1.4	0.7	1.0	1.0	0.8	0.9
Mineral and other dietary supplements	0.8	1.1	2.5	-1.2	-0.8	-0.5	-0.5	-1.1	-1.0	0.7	0.8	1.6	-1.2	-1.1	-1.2	-1.1
Breast cancer (self-reported)	0.2	0.2	1.1	-0.2	-0.6	-0.5	-0.4	0.3	0.1	0.1	-1.0	-0.0	-0.3	-0.4	-0.4	-0.1
Asthma (self-reported)	0.2	0.5	1.7	-0.5	-0.7	-1.0	-1.2	-0.9	-0.6	-0.0	-0.1	1.3	-0.1	-0.2	-0.3	-0.2
Osteoporosis (self-reported)	0.4	0.5	2.2	0.3	0.0	-0.1	-0.7	-1.1	0.4	-0.6	1.2	1.5	0.4	0.6	0.3	0.6
Osteoarthritis (self-reported)	0.6	0.8	1.8	0.9	0.5	0.3	0.2	0.5	1.0	-1.3	-0.5	-0.8	1.3	1.2	1.2	1.1
Medication: Aspirin	1.0	1.3	3.5	-1.0	-1.1	-1.7	-0.6	-0.6	-0.9	1.3	1.2	1.9	-1.0	-1.1	-1.3	-0.5
Medication: Gliclazide	0.6	0.6	1.4	0.9	0.8	0.3	0.8	1.2	0.8	-0.1	0.8	-0.7	0.9	0.7	0.7	1.1
Illnesses of father: None of the above (group 1)	3.3	4.1	7.3	2.4	2.6	2.7	1.8	1.6	2.3	-1.4	1.0	-2.3	1.8	2.0	2.2	1.7
Smoking status: Current	0.3	0.6	1.8	-0.0	0.8	0.9	1.3	0.9	-0.0	1.3	0.8	-0.7	-0.4	-0.3	-0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.7	-1.0	-0.6	-0.6	-1.6	-1.7	-1.4	-0.8	0.3	1.5	-0.1	-0.1	-0.2	-0.8
Whole body water mass	1.4	8.0	14.7	3.2	3.2	3.8	1.6	1.6	3.7	-2.5	0.5	-2.9	2.5	3.2	3.2	2.7
Leg predicted mass (right)	1.4	7.7	17.0	3.1	3.3	4.1	1.2	0.8	3.6	-2.7	1.1	-2.1	2.5	3.3	3.3	2.6
Arm fat mass (left)	1.4	5.6	10.4	2.6	2.8	3.2	0.6	-0.1	2.9	-2.4	2.1	-0.6	2.3	3.1	2.9	2.3
Number of self-reported non-cancer illnesses	1.2	2.1	3.5	-1.7	-1.3	-1.9	-1.2	-0.7	-1.9	1.5	1.1	1.9	-1.2	-1.5	-1.6	-1.1
Average weekly champagne plus white wine intake	0.8	1.1	3.5	-0.9	-0.4	0.0	-1.7	-1.9	-1.0	-1.6	-1.1	1.0	0.0	0.2	0.1	-0.8
Miserableness	0.3	0.5	1.8	-0.8	-0.3	-0.2	-0.7	-1.3	-0.5	-0.2	0.9	1.3	-0.4	-0.2	-0.3	-0.5
Guilty feelings	2.7	4.0	8.0	-2.4	-2.2	-2.2	-2.4	-2.5	-2.0	0.2	-1.0	2.8	-1.6	-1.6	-1.9	-1.7
Wears glasses or contact lenses	2.2	2.6	6.8	-1.6	-1.3	-1.4	-2.6	-2.6	-2.1	-1.2	-1.3	2.2	-0.2	-0.3	-0.4	-1.2
Ever taken oral contraceptive pill	0.7	0.7	1.5	0.8	1.1	1.0	0.2	0.1	0.6	-1.0	0.6	-0.4	1.1	1.2	1.2	0.8
Hearing aid user	0.4	0.5	2.7	0.1	0.2	-0.1	1.2	0.7	0.4	1.0	1.6	0.1	-0.4	-0.3	-0.4	0.3
Mother’s age at death	2.4	3.0	4.3	-2.0	-2.1	-1.4	-1.7	-1.8	-1.8	0.6	-1.7	1.5	-1.8	-1.8	-1.7	-2.1
Financial situation satisfaction	0.9	1.1	5.5	0.2	-0.0	-0.6	1.1	1.0	0.5	2.0	2.3	0.4	-0.7	-0.7	-0.8	0.5
Tinnitus: Yes, now most or all of the time	4.3	5.0	9.1	-2.6	-1.9	-1.1	-0.4	-1.2	-2.5	2.6	1.3	1.8	-3.0	-2.9	-2.8	-3.0
Commuting to job workplace: Public transport	2.9	3.5	5.4	-2.3	-2.0	-1.9	-1.8	-1.4	-2.0	1.3	-0.9	2.0	-2.0	-2.1	-2.2	-1.8
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	0.4	0.8	0.4	1.5	1.1	0.3	0.6	0.3	-1.2	0.6	0.4	0.5	0.5
Medication: Blood pressure	0.8	1.4	2.6	1.3	1.5	1.1	0.5	0.7	0.9	-0.9	1.1	-0.7	1.6	1.6	1.6	1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	-0.8	-0.5	-0.4	-0.7	-1.2	-0.8	0.6	1.2	1.4	-0.6	-0.5	-0.7	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	1.1	0.6	0.2	0.1	0.9	0.9	-0.8	-0.8	-1.3	1.3	1.1	1.2	1.2
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.3	-0.5	-1.0	-0.1	-0.3	-0.4	0.7	0.2	1.0	-0.2	-0.4	-0.5	-0.0
Medication: Bendroflumethiazide	0.5	0.7	2.0	0.8	0.8	0.2	-0.4	0.2	0.5	-0.6	0.4	-0.2	1.4	1.3	1.2	1.2
Medication: Paracetamol	1.1	1.6	3.9	1.1	1.7	1.0	0.3	0.4	0.4	-1.3	1.2	-0.8	2.0	1.8	1.8	1.4
Medication: Lisinopril	0.9	1.1	2.9	-1.3	-1.1	-0.7	-1.0	-1.3	-1.4	-0.4	-1.7	0.9	-0.7	-0.7	-0.7	-1.3
Medication: Atorvastatin	0.7	0.9	4.0	-0.8	-0.2	-0.3	0.6	0.3	-0.4	2.0	1.5	0.8	-1.1	-1.0	-1.2	-0.4
Illnesses of father: High blood pressure	1.7	2.1	3.4	1.7	1.7	1.4	1.0	0.8	1.6	-0.7	0.8	-1.2	1.8	1.8	1.8	1.8
Alcohol drinker status: Never	0.8	0.9	3.9	-0.1	0.1	0.8	0.9	0.4	0.2	1.9	2.0	0.0	-1.1	-0.7	-0.8	-0.4
Ever smoked	2.3	4.0	8.1	-2.7	-2.0	-2.3	-1.9	-1.7	-2.8	1.1	-0.5	2.1	-1.7	-2.0	-2.1	-2.0
Basal metabolic rate	1.9	10.3	19.0	3.7	3.8	4.4	1.8	1.7	4.2	-2.8	1.0	-3.0	3.0	3.7	3.7	3.1
Leg fat percentage (left)	0.7	2.4	5.6	1.7	2.0	2.1	1.3	0.7	2.0	-0.4	2.4	-0.6	1.1	1.5	1.4	1.5
Arm fat-free mass (left)	1.5	7.6	14.1	3.2	3.2	3.7	2.0	2.0	3.8	-1.9	0.9	-3.0	2.3	2.9	2.9	2.7
Number of operations (self-reported)	0.5	0.7	1.8	-0.7	-0.2	0.8	-0.5	-0.8	-0.5	0.6	1.3	0.7	-1.1	-0.8	-0.7	-1.2
Average weekly beer plus cider intake	0.5	0.8	1.9	0.3	1.0	1.2	-0.7	-1.0	-0.1	-1.2	1.4	0.6	0.7	1.0	0.8	0.3
Irritability	0.4	0.6	2.2	-0.4	-0.1	-0.1	-1.3	-1.5	-0.2	-1.0	0.9	1.4	0.3	0.5	0.3	0.1
Risk taking	0.8	1.2	5.3	0.4	0.1	0.1	-1.3	-1.4	0.5	-2.3	-0.8	0.9	1.1	1.3	1.1	0.7
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.6	-1.5	-1.1	-0.9	-1.2	-0.5	-1.6	0.3	-1.3	0.3	-1.0	-1.3	-1.1	-1.6
Fractured/broken bones in last 5 years	0.4	0.5	1.6	-0.8	-0.6	-0.7	-0.5	-0.9	-0.4	0.3	-0.1	1.3	-0.6	-0.5	-0.7	-0.3
Age started oral contraceptive pill	0.7	0.9	3.6	-1.0	-1.0	-1.9	-0.1	-0.0	-0.9	1.1	0.2	1.1	-0.6	-0.9	-1.1	-0.2
Diastolic blood pressure, automated reading	2.6	8.1	14.1	3.2	3.3	3.8	1.8	1.3	3.7	-2.3	1.5	-2.1	2.7	3.4	3.4	2.9
Ever depressed for a whole week	0.2	0.2	0.8	0.2	0.2	-0.2	-0.1	-0.2	0.9	-0.1	0.7	0.6	0.3	0.4	0.2	0.9
Unable to work because of sickness or disability	0.6	0.8	3.2	-0.0	0.1	0.3	1.2	1.2	0.2	1.8	1.2	-0.4	-0.8	-0.9	-0.8	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.3	0.0	0.3	-0.3	-0.6	-0.4	0.2	0.2	0.4	-0.2	-0.0	-0.1	-0.3
Myopia	0.1	0.2	0.9	0.4	-0.2	-1.0	0.2	0.3	0.3	0.3	-0.0	0.4	0.5	0.3	0.2	0.8
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.5	0.1	0.0	0.2	0.7	0.3	0.3	0.1	-0.0	-0.4	-0.3	-0.2	-0.2	-0.1
Cholesterol lowering medication	1.3	1.9	3.8	1.7	1.4	1.1	2.0	1.6	1.6	0.0	1.1	-1.4	1.2	1.2	1.3	1.5
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	6.9	1.7	1.0	-0.2	-0.1	0.1	1.4	-2.1	-1.1	-0.7	2.6	2.3	2.2	2.3
Pain experienced in last month	0.4	0.6	1.7	-0.2	-1.0	-1.0	0.4	0.7	-0.2	1.3	-1.2	-0.1	-0.8	-1.0	-0.9	-0.4
Supplements: Calcium	0.2	0.2	0.5	0.3	0.4	0.4	-0.1	-0.2	0.3	-0.7	0.5	0.0	0.5	0.6	0.6	0.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	0.5	0.7	1.0	0.7	0.6	0.7	-0.1	0.8	-0.8	0.1	0.2	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	-0.4	-0.3	-0.4	-0.5	-1.0	-0.3	0.0	1.4	1.5	-0.2	-0.1	-0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.6	-1.3	-1.1	-0.4	-0.1	0.5	-1.0	1.6	-1.2	-0.6	-1.9	-1.9	-1.6	-1.9
Heart disease (siblings)	0.6	0.7	3.4	-0.7	-1.1	-1.8	-0.8	0.0	-0.6	0.4	-1.5	0.1	-0.1	-0.6	-0.6	-0.2
Alcohol drinker status: Previous	0.8	0.9	2.3	-1.1	-0.9	-0.7	-1.5	-1.3	-1.0	-0.5	-1.5	0.9	-0.5	-0.5	-0.6	-0.9
Pack years of smoking	1.1	1.6	3.8	-1.3	-1.6	-1.9	-1.7	-1.2	-1.2	0.4	-0.8	1.6	-0.8	-1.1	-1.2	-0.8
Impedance of whole body	0.5	2.5	3.9	2.0	1.9	1.8	1.2	0.7	1.5	-0.9	1.8	-0.9	1.7	1.9	1.9	1.7
Leg fat mass (left)	1.8	6.9	13.6	3.0	3.2	3.7	1.7	1.0	3.5	-1.8	2.4	-1.5	2.2	3.0	2.9	2.6
Arm predicted mass (left)	1.6	8.4	15.3	3.4	3.4	3.9	2.1	2.2	3.9	-2.0	0.7	-3.3	2.4	3.0	3.1	2.7