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chr7:91,046,993-93,476,736

Best TWAS P=6.64e-122 · Best GWAS P=1.75e-113 conditioned to 0.353

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	GTEx	Testis	CDK6	0.10	0.10	lasso	3	0.09	8.0e-05	22.41	-23.5	6.6e-122	-0.92	0.01	0.98	TRUE
32	GTEx	Skin Not Sun Exposed Suprapubic	SAMD9L	0.20	0.11	enet	19	0.06	3.6e-04	2.88	-7.5	4.3e-14	0.01	0.36	0.03	TRUE
30	GTEx	Pituitary	KRIT1	0.21	-0.01	enet	14	0.20	1.1e-05	0.66	-7.4	1.4e-13	-0.09	0.29	0.07	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CDK6	0.12	0.10	lasso	2	0.10	1.9e-12	22.50	22.5	2.8e-112	0.99	0.01	0.99	FALSE
16	GTEx	Cells Transformed fibroblasts	GATAD1	0.23	0.20	lasso	4	0.22	1.4e-16	12.16	-16.0	8.2e-58	-0.56	1.00	0.00	FALSE
46	YFS	Blood	GATAD1	0.01	0.01	blup	297	0.01	5.1e-04	12.16	-14.8	2.7e-49	-0.54	0.72	0.12	FALSE
21	GTEx	Esophagus Muscularis	FAM133B	0.07	0.01	enet	2	0.01	1.2e-01	-14.59	-14.3	2.6e-46	-0.46	0.07	0.37	FALSE
13	GTEx	Brain Caudate basal ganglia	GATAD1	0.21	0.09	lasso	4	0.08	2.3e-03	9.02	-13.5	1.7e-41	-0.43	0.08	0.24	FALSE
19	GTEx	Esophagus Mucosa	GATAD1	0.16	0.05	enet	16	0.08	7.3e-06	12.16	-13.2	1.2e-39	-0.41	0.83	0.03	FALSE
5	GTEx	Adrenal Gland	GATAD1	0.40	0.22	lasso	7	0.25	2.0e-09	12.16	-13.1	4.1e-39	-0.46	0.67	0.08	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	GATAD1	0.17	0.15	lasso	4	0.16	6.0e-20	12.55	-13.0	9.4e-39	-0.43	1.00	0.00	FALSE
38	GTEx	Stomach	GATAD1	0.30	0.13	lasso	5	0.15	8.6e-08	12.16	-12.8	9.8e-38	-0.46	0.98	0.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	GATAD1	0.30	0.10	enet	14	0.16	7.0e-13	12.16	-12.7	4.7e-37	-0.39	1.00	0.00	FALSE
18	GTEx	Colon Transverse	GATAD1	0.13	0.00	enet	16	0.05	3.0e-03	12.16	-12.7	7.4e-37	-0.37	0.22	0.10	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	GATAD1	0.22	0.27	lasso	4	0.26	1.1e-14	12.16	-12.6	2.2e-36	-0.41	1.00	0.00	FALSE
8	GTEx	Artery Coronary	GATAD1	0.12	0.15	lasso	3	0.12	8.0e-05	12.00	-12.4	1.8e-35	-0.41	0.20	0.13	FALSE
4	GTEx	Adipose Visceral Omentum	GATAD1	0.12	0.08	lasso	5	0.06	7.5e-04	12.16	-12.4	3.7e-35	-0.45	0.82	0.06	FALSE
22	GTEx	Lung	GATAD1	0.15	0.12	lasso	2	0.11	1.1e-08	12.16	-12.3	7.7e-35	-0.41	0.99	0.00	FALSE
33	GTEx	Skin Sun Exposed Lower leg	PEX1	0.18	0.06	enet	41	0.03	1.5e-03	-11.53	-12.1	1.7e-33	-0.39	0.22	0.11	FALSE
26	GTEx	Muscle Skeletal	GATAD1	0.05	0.00	enet	13	0.01	2.4e-02	4.96	-11.9	1.1e-32	-0.38	0.48	0.02	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GATAD1	0.04	0.04	lasso	2	0.03	2.8e-04	12.22	-11.8	3.5e-32	-0.35	0.06	0.64	FALSE
7	GTEx	Artery Aorta	GATAD1	0.09	0.08	enet	4	0.07	7.4e-05	12.16	-11.8	4.9e-32	-0.42	0.53	0.04	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	GATAD1	0.06	0.04	lasso	6	0.04	2.2e-09	12.22	-11.7	1.6e-31	-0.30	0.12	0.88	FALSE
10	GTEx	Artery Tibial	GATAD1	0.14	0.04	enet	17	0.04	4.1e-04	12.16	-11.6	3.0e-31	-0.38	0.71	0.09	FALSE
40	GTEx	Thyroid	GATAD1	0.18	0.06	lasso	4	0.06	3.3e-05	12.16	-11.6	4.3e-31	-0.42	0.95	0.03	FALSE
20	GTEx	Esophagus Muscularis	GATAD1	0.18	0.10	enet	33	0.13	1.6e-08	12.16	-11.1	1.1e-28	-0.31	0.98	0.00	FALSE
29	GTEx	Pancreas	GATAD1	0.12	0.13	lasso	2	0.14	2.0e-06	12.16	-11.0	3.0e-28	-0.38	0.24	0.27	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	KRIT1	0.04	0.03	bslmm	311	0.01	9.0e-03	5.23	10.7	8.9e-27	0.49	0.74	0.06	FALSE
6	GTEx	Artery Aorta	KRIT1	0.15	0.00	enet	24	0.03	1.3e-02	0.87	-10.5	6.4e-26	-0.27	0.12	0.08	FALSE
41	METSIM	Adipose	GATAD1	0.10	0.05	lasso	7	0.06	9.4e-10	4.96	-10.3	9.9e-25	-0.39	1.00	0.00	FALSE
25	GTEx	Muscle Skeletal	PEX1	0.06	0.03	lasso	5	0.02	2.7e-03	9.48	10.2	2.9e-24	0.29	0.56	0.10	FALSE
15	GTEx	Breast Mammary Tissue (Female)	AC007566.10	0.04	-0.01	lasso	2	0.01	2.0e-01	0.90	-10.1	6.6e-24	-0.37	0.02	0.26	FALSE
28	GTEx	Nerve Tibial	GATAD1	0.30	0.19	lasso	5	0.23	1.8e-16	12.16	-10.1	7.4e-24	-0.34	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	GATAD1	0.21	0.14	enet	10	0.16	3.4e-13	12.16	-10.0	1.1e-23	-0.36	1.00	0.00	FALSE
36	GTEx	Spleen	PEX1	0.18	0.00	enet	38	0.05	2.4e-02	5.22	-9.3	1.7e-20	-0.31	0.08	0.05	FALSE
12	GTEx	Artery Tibial	AC007566.10	0.13	0.04	lasso	5	0.00	3.1e-01	7.01	-8.7	5.2e-18	-0.16	0.08	0.04	FALSE
14	GTEx	Brain Cortex	AC000120.7	0.12	0.08	enet	16	0.07	7.0e-03	5.08	-8.6	5.9e-18	-0.41	0.14	0.05	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C7orf64	0.06	0.02	blup	36	0.02	6.0e-02	9.65	8.1	5.5e-16	0.22	0.02	0.55	FALSE
45	YFS	Blood	CYP51A1	0.03	0.06	blup	288	0.05	1.2e-16	5.13	-7.5	7.3e-14	-0.31	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KRIT1	0.04	0.01	blup	318	0.02	1.2e-03	4.93	-6.8	1.3e-11	-0.22	0.60	0.02	FALSE
11	GTEx	Artery Tibial	AC000120.7	0.08	0.06	lasso	4	0.06	3.2e-05	4.60	-6.6	4.2e-11	-0.26	0.96	0.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	AC000120.7	0.06	0.00	enet	24	0.00	7.9e-01	2.69	-5.7	9.9e-09	-0.12	0.15	0.03	FALSE
24	GTEx	Muscle Skeletal	CYP51A1	0.10	0.18	enet	21	0.17	5.0e-16	4.95	-5.7	1.0e-08	-0.24	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	ANKIB1	0.04	0.04	enet	2	0.02	8.5e-03	5.42	-5.6	1.7e-08	-0.26	0.43	0.03	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	ANKIB1	0.03	0.03	enet	8	0.03	2.6e-04	5.37	-5.5	3.2e-08	-0.28	0.70	0.01	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	CYP51A1	0.03	0.03	enet	12	0.03	1.2e-04	5.34	-5.5	4.7e-08	-0.27	0.02	0.95	FALSE
37	GTEx	Spleen	AC000120.7	0.10	0.07	lasso	5	0.04	3.9e-02	5.09	-5.4	5.7e-08	-0.23	0.15	0.08	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CYP51A1	0.07	0.04	lasso	2	0.04	4.3e-05	5.37	-5.4	6.6e-08	-0.27	0.02	0.98	FALSE
9	GTEx	Artery Coronary	AC000120.7	0.07	0.04	lasso	4	0.02	6.8e-02	5.09	-5.4	7.6e-08	-0.24	0.20	0.05	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYP51A1	0.01	0.02	blup	51	0.02	2.0e-04	5.07	-5.3	1.2e-07	-0.23	0.05	0.92	FALSE
17	GTEx	Cells Transformed fibroblasts	AC000120.7	0.04	0.05	lasso	4	0.04	5.2e-04	5.04	-5.2	1.6e-07	-0.22	0.82	0.01	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP51A1	0.01	0.01	blup	51	0.01	1.2e-02	5.08	-5.2	2.0e-07	-0.23	0.03	0.67	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP51A1	0.04	0.05	blup	51	0.05	9.4e-07	4.92	-5.2	2.2e-07	-0.23	0.05	0.94	FALSE
23	GTEx	Lung	AC000120.7	0.04	0.03	lasso	3	0.01	4.8e-02	5.09	-5.2	2.4e-07	-0.21	0.46	0.02	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC401387	0.04	0.00	lasso	1	0.00	1.6e-01	5.14	5.1	2.8e-07	0.23	0.02	0.62	FALSE