Best TWAS P=8.24e-10 · Best GWAS P=2.86e-13 conditioned to 9.04e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | GS1-259H13.2 | 0.23 | 0.12 | lasso | 1 | 0.09 | 1.8e-05 | 5.4 | -5.4 | 6.7e-08 | -0.24 | 0.59 | 0.34 | FALSE |
| 2 | GTEx | Artery Tibial | ACHE | 0.10 | 0.09 | lasso | 5 | 0.08 | 9.2e-07 | 5.3 | 5.3 | 1.0e-07 | 0.05 | 0.10 | 0.89 | FALSE |
| 3 | GTEx | Brain Cerebellum | RASA4DP | 0.23 | 0.04 | enet | 12 | 0.06 | 6.5e-03 | 4.1 | 5.1 | 2.8e-07 | 0.00 | 0.00 | 0.06 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | AP1S1 | 0.18 | 0.14 | lasso | 4 | 0.12 | 1.5e-06 | -4.5 | -5.7 | 1.6e-08 | -0.01 | 0.12 | 0.86 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | PRKRIP1 | 0.14 | -0.01 | lasso | 4 | 0.00 | 3.4e-01 | -4.4 | 5.6 | 2.4e-08 | 0.05 | 0.01 | 0.04 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Female) | ATP5J2 | 0.13 | 0.04 | enet | 10 | 0.10 | 5.5e-04 | -4.2 | -5.5 | 4.1e-08 | -0.01 | 0.06 | 0.22 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | 5.3 | 5.4 | 7.5e-08 | 0.24 | 0.29 | 0.29 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | POLR2J3 | 0.32 | 0.08 | lasso | 7 | 0.11 | 8.6e-09 | 4.1 | 5.3 | 1.3e-07 | 0.03 | 0.06 | 0.77 | FALSE |
| 9 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | 5.4 | -5.5 | 4.3e-08 | -0.24 | 0.27 | 0.62 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | SRRT | 0.14 | 0.01 | enet | 10 | 0.02 | 4.5e-02 | 4.9 | 5.5 | 4.2e-08 | 0.03 | 0.07 | 0.32 | FALSE |
| 11 | GTEx | Lung | GS1-259H13.2 | 0.09 | 0.07 | lasso | 4 | 0.05 | 8.4e-05 | 5.4 | -5.4 | 5.4e-08 | -0.25 | 0.50 | 0.40 | FALSE |
| 12 | GTEx | Nerve Tibial | GS1-259H13.2 | 0.15 | 0.10 | lasso | 4 | 0.09 | 3.4e-07 | 5.4 | -5.4 | 7.5e-08 | -0.24 | 0.67 | 0.33 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | POLR2J3 | 0.17 | 0.06 | enet | 15 | 0.08 | 5.1e-07 | 4.1 | 5.8 | 8.5e-09 | -0.03 | 0.06 | 0.65 | TRUE |
| 14 | GTEx | Skin Sun Exposed Lower leg | RP11-514P8.8 | 0.17 | 0.08 | enet | 14 | 0.11 | 2.2e-09 | 4.1 | 5.6 | 2.6e-08 | -0.02 | 0.06 | 0.75 | FALSE |
| 15 | GTEx | Thyroid | ACHE | 0.19 | 0.10 | enet | 33 | 0.14 | 1.5e-10 | 5.3 | 5.6 | 1.7e-08 | 0.00 | 0.10 | 0.90 | FALSE |
| 16 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | 5.6 | -5.6 | 2.5e-08 | -0.25 | 0.33 | 0.61 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | SRRT | 0.05 | 0.02 | bslmm | 331 | 0.02 | 1.1e-03 | 5.3 | 5.9 | 4.6e-09 | 0.12 | 0.18 | 0.65 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | AP1S1 | 0.28 | 0.27 | bslmm | 377 | 0.27 | 1.2e-34 | -4.5 | -5.2 | 2.1e-07 | -0.02 | 0.89 | 0.11 | FALSE |
| 19 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | UFSP1 | 0.09 | 0.03 | blup | 53 | 0.05 | 1.2e-03 | 4.6 | -6.0 | 2.6e-09 | -0.03 | 0.02 | 0.56 | TRUE |
| 20 | The Cancer Genome Atlas | Glioblastoma Multiforme | EPHB4 | 0.16 | 0.11 | enet | 7 | 0.07 | 3.8e-03 | 5.3 | -5.2 | 1.7e-07 | -0.06 | 0.00 | 0.90 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | 5.9 | 5.9 | 3.9e-09 | 0.17 | 0.01 | 0.98 | TRUE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C7orf52 | 0.23 | 0.10 | blup | 54 | 0.12 | 7.0e-06 | -4.5 | 6.1 | 8.2e-10 | 0.01 | 0.16 | 0.79 | TRUE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZKSCAN5 | 0.03 | 0.03 | enet | 8 | 0.03 | 5.4e-04 | 5.9 | 5.3 | 1.1e-07 | 0.16 | 0.01 | 0.83 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | C7orf52 | 0.09 | 0.08 | enet | 16 | 0.12 | 1.8e-11 | -5.6 | 5.2 | 2.4e-07 | 0.01 | 0.25 | 0.75 | FALSE |