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chr7:98,341,025-103,015,677

Best TWAS P=8.24e-10 · Best GWAS P=2.86e-13 conditioned to 9.04e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C7orf52	0.23	0.10	blup	54	0.12	7.0e-06	-4.5	6.1	8.2e-10	0.01	0.16	0.79	TRUE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UFSP1	0.09	0.03	blup	53	0.05	1.2e-03	4.6	-6.0	2.6e-09	-0.03	0.02	0.56	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZKSCAN5	0.03	0.04	lasso	2	0.03	1.0e-04	5.9	5.9	3.9e-09	0.17	0.01	0.98	TRUE
13	GTEx	Skin Sun Exposed Lower leg	POLR2J3	0.17	0.06	enet	15	0.08	5.1e-07	4.1	5.8	8.5e-09	-0.03	0.06	0.65	TRUE
5	GTEx	Breast Mammary Tissue (Female)	PRKRIP1	0.14	-0.01	lasso	4	0.00	3.4e-01	-4.4	5.6	2.4e-08	0.05	0.01	0.04	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	SRRT	0.05	0.02	bslmm	331	0.02	1.1e-03	5.3	5.9	4.6e-09	0.12	0.18	0.65	FALSE
4	GTEx	Breast Mammary Tissue	AP1S1	0.18	0.14	lasso	4	0.12	1.5e-06	-4.5	-5.7	1.6e-08	-0.01	0.12	0.86	FALSE
15	GTEx	Thyroid	ACHE	0.19	0.10	enet	33	0.14	1.5e-10	5.3	5.6	1.7e-08	0.00	0.10	0.90	FALSE
16	METSIM	Adipose	GS1-259H13.2	0.04	0.03	lasso	3	0.02	1.4e-03	5.6	-5.6	2.5e-08	-0.25	0.33	0.61	FALSE
14	GTEx	Skin Sun Exposed Lower leg	RP11-514P8.8	0.17	0.08	enet	14	0.11	2.2e-09	4.1	5.6	2.6e-08	-0.02	0.06	0.75	FALSE
6	GTEx	Breast Mammary Tissue (Female)	ATP5J2	0.13	0.04	enet	10	0.10	5.5e-04	-4.2	-5.5	4.1e-08	-0.01	0.06	0.22	FALSE
10	GTEx	Heart Atrial Appendage	SRRT	0.14	0.01	enet	10	0.02	4.5e-02	4.9	5.5	4.2e-08	0.03	0.07	0.32	FALSE
9	GTEx	Esophagus Mucosa	GS1-259H13.2	0.07	0.07	lasso	3	0.05	1.7e-04	5.4	-5.5	4.3e-08	-0.24	0.27	0.62	FALSE
11	GTEx	Lung	GS1-259H13.2	0.09	0.07	lasso	4	0.05	8.4e-05	5.4	-5.4	5.4e-08	-0.25	0.50	0.40	FALSE
1	GTEx	Adipose Visceral Omentum	GS1-259H13.2	0.23	0.12	lasso	1	0.09	1.8e-05	5.4	-5.4	6.7e-08	-0.24	0.59	0.34	FALSE
7	GTEx	Cells Transformed fibroblasts	CPSF4	0.08	0.03	lasso	4	0.03	1.8e-03	5.3	5.4	7.5e-08	0.24	0.29	0.29	FALSE
12	GTEx	Nerve Tibial	GS1-259H13.2	0.15	0.10	lasso	4	0.09	3.4e-07	5.4	-5.4	7.5e-08	-0.24	0.67	0.33	FALSE
2	GTEx	Artery Tibial	ACHE	0.10	0.09	lasso	5	0.08	9.2e-07	5.3	5.3	1.0e-07	0.05	0.10	0.89	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZKSCAN5	0.03	0.03	enet	8	0.03	5.4e-04	5.9	5.3	1.1e-07	0.16	0.01	0.83	FALSE
8	GTEx	Cells Transformed fibroblasts	POLR2J3	0.32	0.08	lasso	7	0.11	8.6e-09	4.1	5.3	1.3e-07	0.03	0.06	0.77	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	EPHB4	0.16	0.11	enet	7	0.07	3.8e-03	5.3	-5.2	1.7e-07	-0.06	0.00	0.90	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	AP1S1	0.28	0.27	bslmm	377	0.27	1.2e-34	-4.5	-5.2	2.1e-07	-0.02	0.89	0.11	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	C7orf52	0.09	0.08	enet	16	0.12	1.8e-11	-5.6	5.2	2.4e-07	0.01	0.25	0.75	FALSE
3	GTEx	Brain Cerebellum	RASA4DP	0.23	0.04	enet	12	0.06	6.5e-03	4.1	5.1	2.8e-07	0.00	0.00	0.06	FALSE