Best TWAS P=1.97e-31 · Best GWAS P=6.22e-26 conditioned to 0.573
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | B4GALNT3 | 0.36 | 0.17 | enet | 27 | 0.25 | 6.3e-14 | 10.5 | -8.3 | 1.3e-16 | -0.74 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | B4GALNT3 | 0.49 | 0.24 | enet | 24 | 0.34 | 6.5e-28 | 10.5 | -11.7 | 2.0e-31 | -0.91 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | KDM5A | 0.24 | 0.01 | lasso | 3 | 0.01 | 1.8e-01 | 4.0 | 7.0 | 2.4e-12 | 0.28 | 0.08 | 0.11 | FALSE |
| 4 | GTEx | Pituitary | PARP11 | 0.45 | 0.16 | lasso | 11 | 0.19 | 1.3e-05 | -2.7 | 5.5 | 5.0e-08 | -0.02 | 0.14 | 0.27 | TRUE |
| 5 | GTEx | Prostate | NINJ2 | 0.48 | 0.00 | enet | 25 | 0.01 | 1.6e-01 | 2.7 | 5.3 | 1.1e-07 | 0.18 | 0.04 | 0.19 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | RHNO1 | 0.21 | 0.04 | enet | 53 | 0.06 | 4.9e-04 | 4.4 | -5.5 | 4.1e-08 | 0.03 | 0.59 | 0.05 | TRUE |
| 7 | METSIM | Adipose | ERC1 | 0.08 | 0.05 | enet | 25 | 0.04 | 9.3e-07 | -2.9 | -5.4 | 8.1e-08 | -0.04 | 0.79 | 0.19 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | B4GALNT3 | 0.05 | 0.04 | lasso | 3 | 0.03 | 7.4e-05 | -5.0 | -5.8 | 6.6e-09 | -0.17 | 0.14 | 0.74 | FALSE |
| 9 | YFS | Blood | SLC6A12 | 0.10 | 0.03 | bslmm | 310 | 0.05 | 6.6e-15 | 3.2 | -5.1 | 3.1e-07 | 0.03 | 1.00 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | B4GALNT3 | 0.07 | 0.02 | blup | 119 | 0.06 | 3.4e-07 | 7.4 | 6.4 | 1.6e-10 | 0.57 | 0.01 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ERC1 | 0.10 | 0.02 | blup | 219 | 0.06 | 7.6e-07 | -2.7 | -6.7 | 2.5e-11 | 0.02 | 0.30 | 0.03 | TRUE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC6A12 | 0.06 | 0.02 | blup | 58 | 0.04 | 5.1e-05 | -4.1 | -5.2 | 2.4e-07 | -0.04 | 0.40 | 0.16 | TRUE |