TWAS hub - SLC6A12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0732	0.0244	3.0e-05	0.009	0.019	0.014	0.020	0.016	1.6e-02	5.9e-04	2.7e-03	4.5e-04	1.6e-03
2	YFS	Blood	0.0984	0.0246	1.6e-10	0.028	0.046	0.036	0.046	0.035	1.0e-09	9.0e-15	8.6e-12	6.6e-15	1.6e-11
3	TCGA	Breast Invasive Carcinoma	0.0261	0.0126	1.8e-03	0.021	0.013	0.018	NA	0.017	2.5e-05	6.9e-04	1.0e-04	NA	1.4e-04
4	TCGA	Prostate Adenocarcinoma	0.0605	0.0229	1.3e-05	0.017	0.040	0.021	NA	0.023	6.0e-03	5.1e-05	2.8e-03	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	13.0	3.6	-0.2	2.7	1.9
Comparative height size at age 10	3.1	16.9	24.4	3.5	-3.2	-4.6	-4.9
Medication: Levothyroxine sodium	3.0	5.0	9.1	3.0	0.7	2.4	2.2
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.3	9.4	2.3	-2.4	-2.2	-3.1
Chronotype (morning person)	2.9	6.7	16.4	2.4	0.9	1.9	4.0
Osteoarthritis (self-reported)	2.9	3.8	10.2	-0.8	-3.2	-1.6	-1.3
Commuting to job workplace: Public transport	2.7	3.2	7.1	-1.4	-1.1	-2.7	-1.7
Mouth/teeth dental problems: Loose teeth	2.6	3.1	8.5	-0.4	-0.5	-2.9	-1.9
Standing height	2.5	24.6	26.6	4.6	-5.1	-5.0	-5.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	8.4	2.9	2.0	-0.3	-0.6
Length of working week for main job	2.4	2.7	6.4	2.5	1.9	0.1	0.9
Cholesterol lowering medication	2.4	3.5	7.1	1.3	1.4	1.8	2.7
Hypothyroidism (self reported)	2.3	5.3	13.1	3.6	-0.5	2.3	1.6
Multivitamins +/- minerals	2.3	2.9	5.1	0.9	1.2	-2.3	-2.1
Prospective memory result	2.3	2.9	8.1	0.1	0.1	2.8	1.8
Medication for cholesterol	2.3	3.5	6.6	-1.0	-0.5	-2.5	-2.6
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	7.7	-1.0	0.6	-2.8	-1.4
Illnesses of father: High blood pressure	2.1	2.6	6.7	2.6	0.8	1.4	1.0
Lupus	2.0	3.1	7.8	-2.8	-0.9	-1.4	-1.3
Height	2.0	37.6	43.9	6.6	-5.0	-6.3	-6.5
Medication: Atenolol	2.0	2.5	9.4	0.2	3.1	0.6	0.4
Had menopause	2.0	2.5	6.0	-2.5	0.7	0.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	5.4	0.5	2.3	1.9	1.6
Medication: Blood pressure	2.0	3.8	7.6	1.3	1.1	2.8	2.2
Wears glasses or contact lenses	1.9	2.1	4.0	-1.6	-0.5	-1.3	-2.0
Major Depression (MDD)	1.8	2.2	5.2	1.9	2.3	0.0	0.0
Medication: Co-codamol	1.8	2.1	3.3	1.5	0.5	-1.7	-1.8
Hearing difficulty/problems with background noise	1.7	2.7	6.2	-0.1	-0.6	-2.5	-2.0
Emphysema/chronic bronchitis	1.7	1.9	4.0	2.0	0.2	1.3	1.4
Vitamin and mineral supplements	1.6	2.2	4.5	-1.4	-1.1	2.1	1.1
Age started oral contraceptive pill	1.6	2.0	4.7	-2.2	0.1	1.4	1.1
Coronary Artery Disease (CAD)	1.5	1.8	5.1	2.3	1.4	0.0	0.0
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.7	2.4	1.1	-0.7	0.7
Supplements: Glucosamine	1.5	2.0	4.9	0.5	-1.6	-0.7	-2.2
Breastfed as a baby	1.5	1.8	3.9	0.7	1.3	1.1	2.0
Shortness of breath walking on level ground	1.5	1.7	3.1	1.8	1.8	-0.7	-0.5
Schizophrenia vs Biploar Disorder	1.4	1.8	4.1	-0.1	-0.5	1.7	2.0
Alzheimer’s Disease (in father)	1.4	1.5	3.0	-1.7	-0.8	-0.7	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.8	1.0	0.3	1.7	1.6
Medication: Lansoprazole	1.4	1.6	2.4	-1.5	-0.8	1.3	1.2
Number of full brothers	1.4	1.8	3.9	0.6	1.3	1.1	2.0
Suffer from ‘nerves’	1.4	2.3	4.2	-0.9	-0.1	2.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.8	0.0	-0.8	-1.3	-2.0
Medication for hormone replacement therapy	1.3	1.5	3.4	-0.3	-0.5	-1.9	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	7.5	2.7	-1.5	-1.3	-0.2
Number of live births	1.3	1.9	4.0	0.4	1.6	0.9	2.0
Asthma	1.3	2.5	7.9	-1.2	-2.8	-0.4	-0.8
Number of children fathered	1.3	1.5	2.8	-0.6	1.2	1.2	1.7
Family relationship satisfaction	1.3	1.6	2.2	-0.8	1.3	-1.5	-1.3
Asthma (self-reported)	1.3	2.6	8.3	-1.1	-2.9	-0.4	-0.7
Age at First Birth	1.2	1.7	3.7	-0.7	-0.7	1.5	1.9
Triglycerides	1.2	2.0	3.1	-1.2	-1.3	1.4	1.8
Respiratory disease	1.2	2.6	7.3	-1.6	-2.7	-0.4	-0.4
Average weekly spirits intake	1.2	1.4	2.2	-0.2	-1.2	-1.4	-1.5
Age when periods started (menarche)	1.2	2.8	5.7	2.3	2.4	-0.0	0.3
Hayfever, allergic rhinitis or eczema	1.2	2.5	6.8	-0.1	-0.1	-1.8	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.5	2.3	-2.2	-0.8	-0.1
Pain all over the body in last month	1.2	1.3	3.0	1.1	1.7	0.8	0.6
Father’s age at death	1.2	1.6	3.9	-1.6	2.0	-0.3	-0.3
Birth weight of first child	1.2	2.2	5.9	0.1	0.0	-1.6	-2.4
Medication: Paracetamol	1.2	2.0	4.4	-0.0	-1.5	-2.1	-1.0
Gout (self-reported)	1.2	1.6	3.2	-1.1	-0.3	-1.8	-1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.9	1.7	1.2	0.9	0.6
Mother’s age at death	1.2	1.5	2.8	-1.7	0.7	-1.3	-1.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.3	0.1	-2.1	-0.3	1.3
Medication: Lisinopril	1.2	1.5	2.9	0.9	-0.0	1.7	1.5
Average weekly beer plus cider intake	1.2	1.8	3.6	1.9	1.8	0.5	-0.0
Severe depression (siblings)	1.1	1.2	2.2	0.2	-0.8	-1.5	-1.4
Medication: Simvastatin	1.1	1.6	3.3	0.9	0.2	1.8	1.5
Pulse wave reflection index	1.1	1.4	3.3	0.3	0.9	1.8	1.1
Heart disease (mother)	1.1	1.3	3.3	-0.6	-0.2	-1.2	-1.8
Alcohol intake frequency.	1.1	2.7	7.6	-0.7	-0.4	1.5	2.8
Leg pain on walking	1.1	1.3	3.4	-1.9	-0.5	-0.5	1.2
Supplements: Calcium	1.1	1.2	3.2	0.7	1.8	-0.8	-0.6
Alcohol drinker status: Previous	1.1	1.3	2.6	-1.6	-0.6	1.0	1.0
Pack years of smoking	1.1	1.6	2.9	0.1	1.4	1.2	1.7
Alzheimer’s Disease (including proxy)	1.0	1.4	2.4	-1.1	-0.0	-1.4	-1.6
Fasting Glucose	1.0	1.2	2.9	-0.2	-0.1	1.4	1.7
Past tobacco smoking	1.0	1.9	4.0	0.1	0.8	1.8	2.0
Had other major operations	1.0	1.2	2.4	0.7	1.0	-1.5	-1.0
Qualifications: None of the above	1.0	2.2	3.5	1.6	1.4	1.0	1.9
Lung cancer (father)	1.0	1.1	1.8	-0.5	-0.9	-1.2	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.0	-1.2	-1.4	-0.4	-1.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.7	-0.2	-1.6	-1.2	-0.8
Migraine (self-reported)	1.0	1.3	2.1	0.6	1.4	1.4	0.7
Financial situation satisfaction	1.0	1.2	1.8	-1.3	-1.0	-1.1	-1.0
Bipolar Disorder (2018)	0.9	1.4	3.1	1.2	0.4	-1.8	-1.0
Ovarian Cancer	0.9	1.1	3.8	2.0	-0.7	0.4	0.3
Falls in the last year	0.9	1.2	1.6	1.3	-1.0	-1.0	1.1
Mouth/teeth dental problems: Dentures	0.9	1.6	3.2	-1.4	-1.8	-1.0	0.0
Illnesses of father: Heart disease	0.9	1.3	3.1	1.8	0.3	0.3	1.4
Smoking status: Previous	0.9	1.4	3.0	0.4	-0.1	-1.5	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.6	-0.4	-1.6	1.1	0.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.2	-0.1	-1.0	1.5	1.0
Commuting to job workplace: Cycle	0.9	1.1	1.5	-0.1	-1.1	-1.2	-1.2
Crohns Disease (2012)	0.8	1.3	2.4	1.0	0.2	1.6	1.4
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	-1.5	-0.4	-0.4	-1.1
Pack years adult smoking proportion	0.8	1.2	2.1	0.1	1.4	0.9	1.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.8	1.7	-0.4	0.5	0.6
Mouth/teeth dental problems	0.8	1.2	4.3	0.2	0.8	2.1	0.2
Happiness	0.8	0.9	1.9	-0.5	1.3	-0.0	-1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.0	-1.5	0.1	-1.3	-1.7
Loud music exposure frequency	0.8	0.9	1.6	-0.8	-1.3	-0.7	-0.9
Medication: Amlodipine	0.8	1.1	1.8	-0.8	-1.1	1.0	1.3
Forced vital capacity (FVC), Best measure	0.8	2.8	9.5	3.1	0.3	-1.2	-0.4
Number of full sisters	0.8	1.0	2.3	-1.5	1.1	-0.5	0.1
Long-standing illness, disability or infirmity	0.8	1.2	2.7	0.6	-1.6	-1.1	-0.9
Commuting to job workplace: Walk	0.8	0.8	2.1	0.3	-0.9	-1.4	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	1.4	-1.0	1.1	1.2	0.7
Medication: Paracetamol	0.8	1.2	3.1	0.5	-1.0	-1.8	-0.8
Medication: Atorvastatin	0.8	1.0	2.0	-1.4	0.3	0.4	1.3
Risk taking	0.8	1.1	3.9	0.1	0.8	-0.1	2.0
Mean Putamen Volume	0.7	0.7	2.0	0.3	-0.6	-0.7	-1.4
Primary Biliary Cirrhosis	0.7	0.9	2.5	0.9	-0.5	1.6	0.4
Heel T-Score	0.7	5.4	20.4	4.5	-0.9	0.1	-0.7
Medication: Metformin	0.7	1.0	1.7	-1.0	0.5	0.9	1.3
Diabetes (father)	0.7	0.8	1.7	-0.9	-0.9	-1.3	-0.2
Diabetes (mother)	0.7	0.8	1.3	-0.6	1.0	1.1	0.8
Serious illness, injury or assault to yourself	0.7	0.8	1.4	0.9	1.2	0.5	0.8
Nervous feelings	0.7	1.3	2.7	-1.6	-1.0	0.8	1.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.8	-0.0	-1.7	-0.4	-0.9
Trunk fat-free mass	0.7	4.3	7.8	2.1	-2.8	-1.4	-1.7
Alcohol intake versus 10 years previously	0.7	1.0	1.8	-1.3	-1.2	0.8	0.5
Trunk predicted mass	0.7	4.2	7.6	2.1	-2.8	-1.4	-1.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.2	-2.1	-0.6	0.1	-0.3
High blood pressure (siblings)	0.7	1.0	1.8	0.8	0.7	1.1	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.2	0.7	0.7	1.1	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.1	0.0	0.3	1.8	0.1
Age at last live birth	0.7	1.0	2.2	-0.4	1.2	0.5	1.5
Knee pain experienced in last month	0.7	1.0	2.2	-0.6	-1.5	-0.5	-1.1
Whole body fat-free mass	0.7	3.9	8.5	1.9	-2.9	-1.1	-1.5
Leg fat-free mass (right)	0.7	3.8	8.5	1.8	-2.9	-1.1	-1.6
Average weekly red wine intake	0.7	1.0	2.2	-1.5	-1.3	0.1	0.4
Back pain experienced in last month	0.7	1.0	2.7	-0.6	0.3	-1.0	-1.6
Whole body water mass	0.7	3.8	7.9	2.0	-2.8	-1.1	-1.5
Leg predicted mass (right)	0.7	3.7	8.1	1.7	-2.8	-1.1	-1.5
Diastolic blood pressure, automated reading	0.7	2.0	4.2	0.3	0.8	1.8	2.1
Crohns Disease (2017)	0.6	1.4	3.0	1.7	1.4	0.5	0.5
Irritable Bowel Disease (IBD)	0.6	1.5	2.9	1.7	1.5	0.5	0.8
Reaction Time	0.6	1.1	2.3	0.9	-0.5	-0.9	-1.5
Ulcerative Colitis	0.6	0.9	1.6	0.6	0.2	1.2	1.3
Allergy or Eczema	0.6	1.7	4.2	-0.5	0.5	-1.4	-2.0
Cardiovascular Disease	0.6	2.0	3.8	-0.4	-1.1	2.0	1.7
Leg fat-free mass (left)	0.6	3.1	7.5	1.8	-2.7	-0.6	-1.1
Sitting height	0.6	3.9	9.1	1.2	-3.0	-1.6	-1.6
Body mass index (BMI)	0.6	2.7	4.3	-1.3	-1.1	2.1	1.9
Leg predicted mass (left)	0.6	3.3	7.8	1.8	-2.8	-0.7	-1.2
Trunk fat mass	0.6	2.4	9.5	-0.5	-3.1	0.0	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	1.5	0.6	-0.0	0.0
Financial difficulties in last 2 years	0.6	0.8	2.7	-0.7	-0.3	-1.6	-0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.3	-0.5	0.4	-0.8	-1.5
Weight	0.6	2.8	9.8	1.0	-3.1	-0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.2	0.9	-0.1	-1.5	-1.0
Arm fat mass (right)	0.6	2.4	7.4	-0.9	-2.7	0.8	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.6	-1.6	-0.1	-0.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.3	1.0	1.1	-1.1	-0.7
Medication: Omeprazole	0.6	0.7	1.2	-1.1	1.1	-0.3	-0.6
Mean time to correctly identify matches	0.6	1.2	2.5	0.7	0.2	-1.3	-1.6
Arm fat percentage (left)	0.6	2.2	2.7	-1.3	-1.6	1.6	1.4
Mood swings	0.6	1.2	1.6	1.3	0.9	0.8	1.2
Medication: Gliclazide	0.6	0.7	2.3	-0.0	1.5	-0.6	-0.1
Ever smoked	0.6	1.1	2.6	-0.0	-0.6	-1.2	-1.6
Basal metabolic rate	0.6	3.6	8.9	1.8	-3.0	-0.9	-1.2
Irritability	0.6	1.0	2.2	-1.0	0.2	-1.5	-0.7
Heart disease (siblings)	0.6	0.8	1.7	-0.2	-0.7	-1.0	-1.3
Alzheimer’s Disease (in mother)	0.5	0.6	2.0	0.6	1.4	0.1	0.2
Ulcerative Colitis (UC)	0.5	0.9	1.8	1.3	1.0	0.4	0.7
LDL Cholesterol	0.5	0.7	1.3	0.9	0.8	0.4	1.1
Lung FEV1/FVC ratio	0.5	2.3	4.7	-2.1	-2.2	0.3	0.3
Lung FVC	0.5	2.7	4.8	1.0	2.2	0.6	2.2
Hand grip strength (left)	0.5	1.3	3.7	1.2	-1.9	0.2	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.7	1.3	0.9	0.2	0.3
Angina	0.5	0.6	1.5	-1.2	0.4	-0.7	-0.6
Supplements: Zinc	0.5	0.5	1.3	-0.3	0.3	0.7	1.1
Trunk fat percentage	0.5	1.9	6.0	-1.1	-2.5	0.7	0.4
Forced vital capacity (FVC)	0.5	1.8	5.7	2.4	0.1	-1.1	-0.5
Allergy	0.5	1.3	3.0	-0.0	1.0	1.0	1.7
Impedance of arm (right)	0.5	2.3	4.7	1.4	-0.9	-1.3	-2.2
Arm fat percentage (right)	0.5	1.9	3.6	-1.3	-1.9	1.1	1.0
Hip circumference	0.5	1.9	7.6	0.4	-2.8	-0.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	1.5	-0.8	0.2	0.1
Medication: Cholesterol lowering	0.5	0.8	1.4	-1.2	-0.9	0.9	0.5
Body fat percentage	0.5	2.0	4.5	-1.5	-2.1	0.7	0.8
Leg fat percentage (right)	0.5	1.7	2.7	-1.1	-0.9	1.5	1.6
Exposure to tobacco smoke outside home	0.5	0.7	1.8	0.1	-0.4	1.3	0.8
Eye problems/disorders: None of the above	0.5	0.5	1.0	-0.3	0.5	-0.9	-1.0
Whole body fat mass	0.5	2.2	7.6	-0.8	-2.8	0.4	0.4
Arm predicted mass (right)	0.5	2.3	6.1	1.4	-2.5	-1.0	-0.6
Overall health rating	0.5	1.2	4.5	2.1	0.2	-0.3	0.2
Chest pain or discomfort	0.5	0.7	1.0	0.8	0.4	-0.9	-1.0
Medication: Aspirin	0.5	0.6	0.9	-0.9	0.1	-1.0	0.8
Diabetes diagnosed by doctor	0.5	0.8	2.1	-1.4	-0.4	0.1	1.0
Breast cancer (self-reported)	0.5	0.6	2.4	-0.2	0.3	-1.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	0.2	1.6	0.8	0.9
Arm fat mass (left)	0.5	2.2	5.8	-0.8	-2.4	1.2	1.0
Ever taken oral contraceptive pill	0.5	0.5	1.3	-0.4	-1.1	0.8	0.1
Arm fat-free mass (left)	0.5	2.6	8.0	0.9	-2.8	-0.9	-0.8
Arm predicted mass (left)	0.5	2.6	8.2	0.9	-2.9	-0.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.6	-1.6	-0.9	-0.7	-0.3
Neuroticism	0.4	1.0	1.9	-1.2	-1.4	-0.7	-0.4
Sensitivity / hurt feelings	0.4	0.8	1.4	-1.1	-1.2	0.5	0.5
Hand grip strength (right)	0.4	1.0	3.4	0.6	-1.8	-0.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	0.6	-0.8	-0.6	-0.8
High blood pressure (mother)	0.4	0.5	1.0	0.7	1.0	0.5	0.6
Waist circumference	0.4	1.4	4.9	-0.2	-2.2	0.5	0.7
Number of incorrect matches in round	0.4	0.7	1.9	-0.9	-0.2	0.1	-1.4
Alcohol usually taken with meals	0.4	0.6	1.8	-1.3	-0.2	-0.7	-0.5
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.5	0.7	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.1	2.0	-0.4	-0.9	-0.3
Arm fat-free mass (right)	0.4	2.3	7.0	1.2	-2.6	-0.7	-0.4
Pulse wave peak to peak time	0.4	0.4	0.6	0.8	-0.8	-0.7	-0.2
Angina (self-reported)	0.4	0.5	1.7	-1.3	0.3	-0.4	-0.3
Medication: Ibuprofen	0.4	0.5	1.0	1.0	-0.6	0.6	0.5
Leg fat mass (right)	0.4	1.5	4.1	-0.6	-2.0	0.6	1.0
Pulse rate, automated reading	0.4	1.3	3.1	-0.1	-0.5	1.3	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.2	-1.0	-0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	-0.6	-1.2	0.2	-0.4
Ever had bowel cancer screening	0.4	0.5	1.5	-1.2	0.4	0.1	-0.4
Mineral and other dietary supplements	0.4	0.5	1.5	-0.2	-0.2	0.6	1.2
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.7	0.7	-1.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.5	0.8	0.3	-0.3	-1.2
High cholesterol (Self-reported)	0.4	0.7	1.5	0.1	-0.3	1.0	1.2
Medication: Bendroflumethiazide	0.4	0.6	1.2	0.7	-0.8	1.1	0.4
Leg fat percentage (left)	0.4	1.3	1.9	-1.4	-1.2	0.8	1.0
Leg fat mass (left)	0.4	1.4	4.4	-0.7	-2.1	0.5	0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	1.3	0.1	-1.0	-0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	-0.9	0.3	1.2	1.0
Worry (Nagel 2018)	0.3	0.6	1.3	-1.1	-0.8	-0.0	0.5
HbA1C	0.3	0.3	0.7	-0.8	0.1	0.4	0.6
Neuroticism (2016)	0.3	0.4	0.9	0.3	0.9	0.7	0.2
Rheumatoid Arthritis	0.3	0.5	0.9	-0.0	1.0	-0.4	0.9
Blood Eosinophil Count	0.3	2.1	5.3	-2.3	-1.3	-0.5	-1.1
BMI	0.3	1.8	4.3	-0.6	0.1	2.1	1.6
Hearing difficulty/problems: Yes	0.3	0.4	0.6	0.8	-0.6	-0.8	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.6	0.3	0.8	-0.8	0.2
Systolic blood pressure, automated reading	0.3	0.8	1.4	-1.2	0.5	0.8	0.9
Townsend deprivation index at recruitment	0.3	0.4	0.7	-0.4	0.4	0.8	0.9
Current tobacco smoking	0.3	0.4	1.3	-1.1	-0.0	-0.4	0.6
Maternal smoking around birth	0.3	0.4	1.0	-0.8	-1.0	-0.1	-0.4
Diabetes (self-reported)	0.3	0.5	1.4	-1.2	-0.3	-0.7	0.1
Illnesses of siblings	0.3	0.4	1.3	-1.1	0.4	-0.0	-0.2
Illnesses of mother	0.3	0.3	0.8	0.2	-0.9	0.4	0.5
Impedance of arm (left)	0.3	1.5	3.0	1.2	-0.8	-0.9	-1.7
Peak expiratory flow (PEF)	0.3	0.8	1.3	-0.6	-1.1	0.6	1.0
Glaucoma (self-reported)	0.3	0.4	1.0	1.0	0.6	0.3	0.4
Birth weight	0.3	0.7	1.8	0.9	-0.2	1.3	-0.3
Comparative body size at age 10	0.3	0.9	1.9	-0.2	1.4	-0.9	-0.9
Qualifications: College or University degree	0.3	0.9	2.0	-0.7	-0.7	-0.7	-1.4
Neck or shoulder pain in last month	0.3	0.5	1.8	0.2	-1.3	0.2	-0.1
Medication: Blood pressure	0.3	0.5	0.8	-0.7	-0.0	0.9	0.8
Medication: Seretide 50 evohaler	0.3	0.4	1.1	-0.1	1.0	0.2	0.6
Supplements: Vitamin C	0.3	0.4	0.8	0.4	0.9	0.1	0.6
Illnesses of siblings: Diabetes	0.3	0.3	0.8	-0.6	-0.9	-0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	0.9	0.5	-0.5	0.9
Medication: Aspirin	0.3	0.4	0.8	-0.6	0.2	-0.9	0.8
Smoking status: Current	0.3	0.5	1.5	-1.2	-0.3	-0.5	0.4
Miserableness	0.3	0.4	1.1	0.1	-0.3	-0.8	-1.0
Guilty feelings	0.3	0.5	0.8	-0.4	-0.8	-0.9	-0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	0.6	0.0	0.9	0.4
Myopia	0.3	0.4	1.0	0.6	1.0	-0.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-1.0	0.8	-0.1	-0.1
Pain experienced in last month	0.3	0.5	0.7	0.8	0.3	0.7	0.8
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.5	0.1	-1.0	-0.5
HDL Cholesterol	0.2	0.4	1.3	1.1	-0.4	-0.3	-0.3
Blood White Count	0.2	1.4	5.0	-2.2	0.1	-0.2	-0.6
Systolic Blood Pressure	0.2	0.9	1.9	-0.6	1.0	1.4	0.5
Smoking Status	0.2	0.6	1.6	-0.5	-0.5	-1.3	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-1.0	0.4	0.3	0.5
Relative age of first facial hair	0.2	0.4	1.0	0.2	-0.7	0.2	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.2	0.1	0.4	0.8
Average weekly fortified wine intake	0.2	0.2	0.4	0.0	0.5	-0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.2	0.8	0.1	0.0
Qualifications: CSEs or equivalent	0.2	0.2	0.7	-0.0	-0.8	-0.5	-0.1
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.4	0.8	-0.5	0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	0.1	0.5	0.7	0.2
Impedance of leg (left)	0.2	0.9	2.5	0.4	-0.5	-1.6	-0.9
Medication: Ramipril	0.2	0.3	0.6	0.6	0.3	0.2	0.8
Time employed in main current job	0.2	0.2	0.7	-0.2	-0.2	-0.8	0.0
Worrier / anxious feelings	0.2	0.3	0.8	0.2	0.2	0.7	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.4	1.6	-0.7	-0.6	0.1
Noisy workplace	0.2	0.2	0.5	0.0	-0.7	0.4	0.5
Depression (self-reported)	0.2	0.3	0.9	0.1	-0.9	-0.4	-0.1
Tense / ‘highly strung’	0.2	0.3	0.7	0.8	0.1	-0.4	0.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.9	-1.4	-0.0	-0.2	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.4	0.5	0.3	0.7
Headache pain in last month	0.2	0.4	0.7	0.0	-0.6	-0.8	-0.6
Worry too long after embarrassment	0.2	0.3	0.7	0.5	0.8	0.3	0.6
Age at first live birth	0.2	0.4	0.9	-0.2	0.7	0.2	0.9
Health satisfaction	0.2	0.2	0.6	-0.2	-0.3	-0.8	-0.4
Medication: Allopurinol	0.2	0.2	0.4	-0.6	0.0	-0.4	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.0	0.5	0.6	0.4
Loneliness, isolation	0.2	0.2	0.8	-0.2	0.9	-0.1	-0.4
Qualifications: nursing, teaching	0.2	0.4	0.9	-0.9	0.4	-0.6	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.3	0.3	-0.7
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	0.7	0.1	1.0	0.4
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.5	0.1	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.2	-0.2	0.6	0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.1	0.5	0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.1	0.6	0.5	0.7
Impedance of whole body	0.2	1.0	1.7	0.8	-0.6	-1.2	-1.3
Depression (Nagel 2018)	0.1	0.2	0.5	0.7	0.3	-0.3	0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-0.5	-0.0	-0.9	-0.4
Schizophrenia (2014)	0.1	0.2	0.7	0.1	-0.8	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.6	-0.8	0.0	0.0	-0.3
Blood Platelet Count	0.1	1.4	3.1	-1.8	-0.7	-0.8	-1.2
Blood Red Count	0.1	1.0	1.9	0.8	-0.2	1.2	1.4
Number of treatments/medications taken	0.1	0.2	0.5	0.7	-0.5	-0.3	0.0
Impedance of leg (right)	0.1	0.2	0.6	0.8	-0.1	-0.6	-0.2
Fed-up feelings	0.1	0.2	0.5	0.4	0.2	-0.7	-0.3
Relative age voice broke	0.1	0.1	0.3	-0.2	-0.1	0.5	0.3
Taking other prescription medications	0.1	0.2	0.8	0.1	-0.9	0.0	-0.2
High blood pressure	0.1	0.3	0.6	0.2	0.2	0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.5	0.0	0.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	0.9	-0.1	-0.0	-0.2
Heart attack	0.1	0.1	0.3	0.4	-0.2	0.2	0.6
Fluid intelligence score	0.1	0.1	0.4	-0.4	0.6	0.2	0.1
Neuroticism score	0.1	0.1	0.3	-0.5	-0.1	0.1	0.5
Pulse rate	0.1	0.2	0.5	-0.3	0.0	-0.2	0.7
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	-0.6	0.3	0.5	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	0.0	-0.4	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.6	-0.2	-0.1	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.0	0.4	0.6	-0.6
Had major operations	0.1	0.1	0.2	-0.2	-0.2	0.4	0.0
Hypertension (Self-reported)	0.1	0.3	0.8	-0.0	0.0	0.7	0.9
Friendships satisfaction	0.1	0.1	0.3	0.4	0.5	0.1	0.1
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.0	0.4	-0.6	0.3
Hearing aid user	0.1	0.1	0.2	-0.5	0.2	-0.1	0.2
Alcohol drinker status: Never	0.1	0.1	0.3	0.5	-0.0	0.3	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.4	-0.5	0.3	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.4	0.3	-0.2	-0.1	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	-0.3	-0.5	-0.5	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.4	-0.2	0.2	0.6
Schizophrenia (2018)	0.0	0.1	0.3	0.5	-0.2	0.0	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.1	0.1	0.1	-0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.2	0.3	-0.0	-0.1	-0.4
Hair Pigment	0.0	0.3	0.7	0.4	0.0	-0.5	0.8
Tanning	0.0	0.4	1.1	-1.0	0.0	0.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	0.0	0.0	0.2	-0.2
Ever depressed for a whole week	0.0	0.0	0.1	-0.3	0.0	0.1	0.0

Hub : Genes

SLC6A12

Models

Trait associations