Hub : Genes

MANSC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.2070	0.0660	3.5e-03	0.113	NA	0.059	NA	0.083	5.9e-08	NA	8.2e-05	NA	3.4e-06
2	YFS	Blood	0.0622	0.0157	1.0e-06	0.047	0.022	0.044	0.042	0.042	5.2e-15	9.6e-08	2.8e-14	1.2e-13	1.6e-13
3	TCGA	Testicular Germ Cell Tumors	0.2170	0.1020	9.4e-03	0.038	0.036	0.021	NA	0.049	1.8e-02	2.0e-02	5.8e-02	NA	7.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.9	-1.0	-0.5	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	-1.3	-0.9	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	-1.4	-0.2	-0.6
Depression (Nagel 2018)	0.5	0.7	0.9	-1.0	0.8	-0.8
Intelligence (Savage-Jansen 2018)	1.2	3.8	6.5	2.5	1.1	1.9
Neuroticism (Nagel 2018)	0.3	0.7	0.9	-0.8	0.7	-1.0
Schizophrenia (2018)	0.2	0.5	0.8	-0.9	-0.8	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.4	-0.5	0.8
Worry (Nagel 2018)	0.3	0.6	1.3	-1.1	0.3	-0.7
Alzheimer’s Disease (in mother)	0.9	1.0	1.6	-0.3	1.3	-1.1
Alzheimer’s Disease (in father)	0.7	0.8	1.4	-0.9	0.3	1.2
Alzheimer’s Disease (including proxy)	0.7	1.1	2.8	-0.7	1.7	-0.1
Crohns Disease (2017)	0.6	1.4	2.8	-0.6	-1.0	1.7
Irritable Bowel Disease (IBD)	0.5	1.1	2.4	-0.3	-0.8	1.6
Ulcerative Colitis (UC)	0.2	0.4	1.2	-0.1	-0.2	1.1
Major Depression (MDD)	0.6	0.7	1.0	1.0	-0.9	-0.7
Reaction Time	0.6	1.2	1.6	-1.3	-0.9	1.0
Verbal and Numeric Reasoning (VNR)	1.4	3.2	7.2	2.7	0.5	1.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.3	1.7	3.5	-1.2	-1.9	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.2	0.6	-0.2	0.8	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.7	-1.6	-0.2	-0.7
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.4	-0.1	0.4
Crohns Disease (2012)	0.3	0.4	0.8	-0.9	-0.2	0.7
Mean Putamen Volume	0.8	0.9	2.5	0.5	1.6	-0.2
Fasting Glucose	0.4	0.4	0.9	0.5	0.3	-0.9
HbA1C	2.1	2.4	4.8	2.2	0.8	-1.3
HDL Cholesterol	0.8	1.4	1.9	-0.9	-1.4	1.2
LDL Cholesterol	0.1	0.1	0.2	-0.2	-0.1	-0.5
Lupus	1.4	2.1	3.7	-1.9	-1.6	-0.1
Neuroticism (2016)	1.5	2.1	3.7	0.5	1.5	-1.9
Primary Biliary Cirrhosis	0.4	0.6	0.8	-0.5	0.9	-0.9
Rheumatoid Arthritis	0.7	0.9	1.8	-0.8	-1.3	0.6
Schizophrenia (2014)	1.3	2.8	4.1	-2.0	-2.0	0.5
Triglycerides	0.1	0.2	0.6	-0.8	-0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.5	1.1	-0.5
Ulcerative Colitis	0.2	0.2	0.3	-0.5	-0.6	0.4
Blood Eosinophil Count	0.0	0.3	0.3	0.6	-0.5	0.4
Blood Platelet Count	0.2	2.1	3.7	1.6	1.9	0.2
Blood Red Count	0.5	4.6	12.6	1.2	0.1	3.5
Blood White Count	0.1	0.7	1.1	-0.2	1.1	0.9
Heel T-Score	0.9	6.9	10.2	1.6	3.2	-2.8
BMI	0.2	0.9	2.6	-0.1	-0.4	-1.6
Height	0.5	9.2	25.2	0.6	1.4	-5.0
Waist Hip Ratio (WHR)	0.1	0.2	0.4	0.3	0.5	-0.6
Systolic Blood Pressure	0.4	2.0	3.1	1.5	-0.8	1.8
Smoking Status	0.5	1.1	1.8	1.1	-0.5	1.3
Allergy or Eczema	0.6	1.6	3.0	1.7	1.0	0.8
Cardiovascular Disease	0.5	1.7	5.2	-0.1	-0.1	2.3
Hypothyroidism (self reported)	0.3	0.8	2.1	-1.4	-0.1	-0.4
Respiratory disease	2.8	6.3	12.4	3.5	2.5	0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.2	-1.8	0.8	-0.5
Lung FEV1/FVC ratio	0.1	0.5	1.4	-1.2	-0.1	0.3
Lung FVC	0.1	0.5	0.6	-0.7	-0.8	0.6
Neuroticism	0.2	0.4	0.7	-0.4	-0.6	-0.8
Chronotype (morning person)	0.9	2.2	4.5	2.1	1.0	1.0
Hair Pigment	0.1	2.4	5.2	1.4	2.3	0.3
Tanning	0.1	1.5	2.2	-1.0	1.5	1.2
Hand grip strength (left)	0.3	0.8	2.3	-0.1	-1.5	-0.2
Number of treatments/medications taken	0.4	0.8	0.9	-0.9	0.9	-0.8
Average weekly spirits intake	1.4	1.7	3.2	1.8	0.6	-1.3
Sensitivity / hurt feelings	0.8	1.4	2.1	1.4	1.0	-1.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	-1.4	0.8	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.6	-0.0	0.7
Relative age of first facial hair	0.4	0.7	0.9	0.8	1.0	0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.9	0.0	-0.8
Ever used hormone-replacement therapy (HRT)	1.8	2.3	3.8	1.9	1.4	-1.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	1.1	-0.2	0.7
Systolic blood pressure, automated reading	0.2	0.7	0.9	0.9	-0.6	1.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.8	-1.9	-1.3	0.5
Angina	0.9	1.1	2.2	-0.7	-0.8	1.5
Medication for hormone replacement therapy	1.1	1.2	2.2	1.5	1.0	0.7
Vitamin and mineral supplements	2.7	3.7	6.2	-2.0	-1.0	2.5
Supplements: Zinc	0.5	0.6	1.4	1.2	0.5	-0.3
Medication: Co-codamol	1.9	2.2	3.4	-1.9	-1.7	-0.6
Medication: Metformin	0.2	0.3	0.5	-0.4	0.7	-0.6
Diabetes (father)	0.6	0.8	1.1	-0.5	-1.1	-1.0
Diabetes (mother)	1.7	2.2	6.3	-2.5	-0.2	-0.4
Severe depression (siblings)	0.4	0.4	0.9	0.6	0.1	-1.0
Pack years adult smoking proportion	0.4	0.6	1.2	0.7	1.1	0.0
Impedance of leg (right)	0.3	1.3	3.4	-1.8	0.4	0.5
Leg fat-free mass (left)	1.1	5.8	16.0	1.2	-0.2	-4.0
Trunk fat percentage	0.6	2.3	6.5	-0.3	-0.4	-2.5
Hand grip strength (right)	0.2	0.7	1.4	1.2	-0.8	-0.2
Townsend deprivation index at recruitment	0.5	0.7	1.4	-0.9	-1.2	0.1
Current tobacco smoking	0.3	0.5	1.2	-0.0	-1.1	0.5
Average weekly fortified wine intake	0.7	0.8	1.6	-1.3	-0.8	-0.5
Maternal smoking around birth	2.2	3.2	6.9	1.5	2.6	0.8
Fed-up feelings	0.4	0.7	1.5	-1.2	0.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.0	-1.4	0.9	-0.4
Relative age voice broke	1.1	1.7	2.7	0.6	1.4	-1.7
Taking other prescription medications	0.4	0.6	0.9	-0.5	1.0	-0.8
Age when periods started (menarche)	0.5	1.3	3.6	-0.2	0.4	-1.9
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	7.5	-0.9	-2.7	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	4.9	2.2	1.8	-1.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	0.2	-0.1
Qualifications: CSEs or equivalent	0.5	0.7	1.9	-0.0	0.4	1.4
Serious illness, injury or assault to yourself	0.3	0.4	0.9	0.3	-0.9	0.3
High blood pressure	0.2	0.7	1.8	-0.4	0.1	1.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	0.7	0.8	0.9
Multivitamins +/- minerals	0.7	0.9	2.6	-0.1	0.5	-1.6
Stomach or abdominal pain in last month	1.4	1.7	3.5	1.9	1.3	-0.4
Supplements: Glucosamine	0.7	0.9	1.6	-0.1	-1.1	1.3
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.7	0.3	0.1	2.4
Medication: Atenolol	0.6	0.7	0.8	-0.7	0.9	-0.9
Medication: Levothyroxine sodium	0.6	1.0	1.7	-1.1	0.0	-1.3
Sitting height	0.3	2.3	6.1	0.6	0.6	-2.5
Chronic bronchitis/emphysema (father)	0.8	0.9	1.3	1.1	0.4	1.1
High blood pressure (mother)	0.7	1.0	2.3	-0.8	-0.4	-1.5
Body mass index (BMI)	0.3	1.1	3.2	0.2	-0.3	-1.8
Impedance of leg (left)	0.3	1.5	4.0	-2.0	0.6	0.4
Leg predicted mass (left)	1.1	5.6	15.3	1.3	-0.2	-3.9
Trunk fat mass	0.9	4.0	12.0	0.0	-0.1	-3.5
Waist circumference	0.7	2.7	8.0	-0.0	-0.1	-2.8
Number of incorrect matches in round	1.1	1.8	5.0	-0.6	0.2	-2.2
Past tobacco smoking	0.5	0.9	2.7	-0.4	-0.1	-1.6
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	-0.1	0.3
Nervous feelings	0.8	1.6	2.8	-0.6	1.2	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	7.6	-2.8	-1.0	1.3
Hearing difficulty/problems with background noise	1.5	2.3	4.8	0.6	1.4	2.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	0.7	-0.1	0.0
Had menopause	0.7	0.9	1.9	0.2	1.4	-0.9
Had other major operations	0.1	0.1	0.1	0.4	-0.2	-0.3
Forced vital capacity (FVC)	0.2	0.7	1.7	0.3	-0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	6.0	2.5	1.9	-1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.6	0.6	1.6	-0.3
Qualifications: None of the above	0.6	1.2	1.9	-1.4	-1.3	0.2
Financial difficulties in last 2 years	0.3	0.5	1.1	-0.1	1.0	0.6
Mouth/teeth dental problems	0.2	0.3	0.4	-0.6	0.2	0.5
Heart attack	2.0	2.6	5.2	-1.5	-0.7	2.3
Allergy	1.7	3.9	6.5	-2.2	-2.5	-0.8
Pain all over the body in last month	2.8	3.0	5.6	-2.4	-1.7	-0.8
Diabetes (self-reported)	0.3	0.4	0.9	-0.2	0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	-1.4	0.4	0.6
Medication: Ramipril	0.8	1.0	1.7	-1.1	0.4	1.3
Medication: Simvastatin	0.7	1.1	2.7	0.6	1.6	-0.4
Fluid intelligence score	0.4	0.8	2.0	1.4	-0.0	0.6
Illnesses of siblings	0.5	0.8	1.0	-0.8	-1.0	0.8
Neuroticism score	0.1	0.2	0.4	-0.7	-0.3	-0.4
Weight	1.3	6.3	18.0	0.9	0.3	-4.2
Impedance of arm (right)	0.2	1.1	1.7	-1.3	-0.7	1.1
Arm fat percentage (right)	0.3	1.3	3.8	-0.1	-0.5	-1.9
Trunk fat-free mass	1.1	6.4	16.7	1.5	0.6	-4.1
Hip circumference	1.1	4.8	14.1	0.5	-0.3	-3.8
Time employed in main current job	1.1	1.3	2.9	0.3	1.0	-1.7
Alcohol intake versus 10 years previously	0.9	1.4	4.0	0.1	2.0	-0.5
Father’s age at death	2.0	2.7	5.1	1.2	2.2	-1.3
Worrier / anxious feelings	0.3	0.6	1.6	-0.1	0.3	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.3	1.0	1.5	0.1
Falls in the last year	0.4	0.6	1.6	0.2	-0.4	-1.3
Hair/balding pattern: Pattern 3	1.2	1.8	3.0	-1.7	-1.3	0.9
Number of live births	0.1	0.2	0.2	-0.3	0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	-0.3	-0.7	-0.9
Pulse rate	0.3	0.6	0.8	-0.8	0.4	-0.9
Happiness	1.0	1.2	2.0	-1.2	-0.5	-1.4
Noisy workplace	0.7	0.9	1.4	-0.7	-1.2	0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.6	0.2	1.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.4	-0.2	0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	0.7	-0.5	0.9
Asthma	2.8	5.6	12.2	3.5	2.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.5	1.6	1.2	0.8
Medication: Cholesterol lowering	2.4	3.7	10.4	0.8	3.2	0.5
Depression (self-reported)	0.6	0.7	1.3	-0.9	1.1	0.3
Medication: Lansoprazole	5.2	5.9	11.1	-2.3	-3.3	1.2
Prospective memory result	1.0	1.3	3.0	0.9	0.1	1.7
Lung cancer (father)	0.9	1.1	2.0	1.0	0.3	1.4
Illnesses of mother	2.5	3.1	5.8	1.5	-1.1	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-0.6	-1.5	-0.4
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	1.0	-0.4	0.2
Impedance of arm (left)	0.2	0.8	1.3	-0.8	-0.6	1.1
Arm fat mass (right)	0.7	2.7	8.2	0.2	-0.2	-2.9
Trunk predicted mass	1.0	5.7	15.0	1.4	0.5	-3.9
Standing height	1.1	10.6	27.7	1.5	1.4	-5.3
Length of working week for main job	0.6	0.7	1.8	1.4	-0.1	0.3
Exposure to tobacco smoke at home	1.2	1.3	2.7	-0.2	1.1	-1.6
Breastfed as a baby	0.7	0.8	2.2	1.5	-0.4	-0.3
Tense / ‘highly strung’	0.6	0.9	2.4	-1.5	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-0.2	1.3	-0.1
Hair/balding pattern: Pattern 4	0.5	1.3	2.2	-1.5	0.5	-1.2
Birth weight of first child	0.6	1.2	3.4	1.8	0.2	-0.3
Peak expiratory flow (PEF)	0.1	0.2	0.3	0.2	0.4	-0.6
Pulse wave reflection index	0.8	1.0	1.1	1.1	-0.9	1.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.4	0.5	0.3	-1.5
Loud music exposure frequency	0.0	0.0	0.1	-0.2	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	4.1	1.7	2.0	0.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.3	-0.8	-0.0	-2.1
Blood clot in the leg (DVT)	1.5	1.9	2.6	0.8	1.6	-1.6
Medication: Paracetamol	0.2	0.3	0.4	-0.3	0.6	-0.6
Headache pain in last month	1.0	1.7	3.3	1.8	1.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.4	0.4	-1.9	-0.7
Glaucoma (self-reported)	0.6	0.7	2.0	0.3	-0.2	-1.4
Gout (self-reported)	1.0	1.3	2.9	-1.7	-0.9	0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.7	-1.1	0.1	-1.6
Medication: Amlodipine	1.5	2.2	3.7	-1.9	-0.9	1.4
Medication: Ventolin 100micrograms inhaler	2.0	2.6	4.8	1.3	1.2	-2.2
Birth weight	1.4	3.0	6.8	0.7	1.3	-2.6
Chronic bronchitis/emphysema (mother)	3.1	3.7	9.9	0.6	3.1	-0.9
High blood pressure (siblings)	0.2	0.2	0.7	0.1	0.8	0.1
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	0.2	-0.8	-0.8
Body fat percentage	0.6	2.2	6.2	-0.5	-0.3	-2.5
Leg fat percentage (right)	0.7	2.5	7.2	-0.7	-0.1	-2.7
Arm fat-free mass (right)	1.3	6.5	18.1	1.2	0.2	-4.3
Exposure to tobacco smoke outside home	0.6	0.8	1.3	0.2	1.1	-1.0
Comparative body size at age 10	0.1	0.4	1.0	-0.5	0.1	-1.0
Number of full brothers	0.3	0.3	0.7	0.9	0.4	-0.2
Worry too long after embarrassment	1.1	1.9	2.7	1.5	1.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.2	-1.5	-0.5	-1.8
Wheeze or whistling in the chest in last year	0.4	0.6	1.4	0.7	0.2	-1.2
Number of children fathered	0.9	1.0	1.5	0.5	1.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	6.7	-1.1	0.2	-2.6
Age at first live birth	0.2	0.3	0.9	0.9	-0.3	0.2
Pulse wave peak to peak time	0.3	0.4	0.8	-0.9	0.4	-0.3
Health satisfaction	0.2	0.2	0.4	0.3	0.7	-0.3
Shortness of breath walking on level ground	0.2	0.3	0.5	0.3	0.5	-0.7
Qualifications: College or University degree	1.2	3.7	6.7	2.6	0.2	2.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	-0.3	0.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.0	1.4	0.4	-1.3
Emphysema/chronic bronchitis	0.3	0.3	0.7	0.3	0.3	0.9
Medication for pain relief, constipation, heartburn	0.7	1.2	2.6	-0.3	-1.6	-0.9
Neck or shoulder pain in last month	0.1	0.2	0.3	0.3	-0.6	0.4
Medication: Blood pressure	0.3	0.5	1.1	-0.3	0.5	1.0
Angina (self-reported)	0.8	1.0	2.0	-0.8	-0.7	1.4
Migraine (self-reported)	1.7	2.1	4.6	2.1	0.8	1.1
Medication: Ibuprofen	2.3	2.7	3.9	1.9	2.0	0.9
Medication: Allopurinol	0.4	0.5	1.3	-1.2	-0.3	0.4
Medication: Omeprazole	0.7	0.8	2.4	-0.1	0.3	-1.5
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.4	0.6	0.8
Mean time to correctly identify matches	1.0	1.8	2.8	-1.7	-1.1	1.2
Heart disease (mother)	0.1	0.2	0.4	0.3	0.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.3	0.7	0.0
Whole body fat mass	0.9	3.8	11.5	-0.1	-0.2	-3.4
Leg fat mass (right)	0.9	3.6	10.8	-0.3	-0.1	-3.3
Arm predicted mass (right)	1.0	5.3	15.1	0.9	0.1	-3.9
Pulse rate, automated reading	0.5	1.5	2.6	-1.6	0.1	-1.4
Alcohol intake frequency.	1.3	3.1	5.6	-1.8	-0.5	-2.4
Comparative height size at age 10	0.5	2.9	7.8	0.8	0.6	-2.8
Number of full sisters	0.7	0.8	1.8	0.4	1.4	0.6
Suffer from ‘nerves’	1.6	2.5	5.9	-0.3	1.2	-2.4
Overall health rating	0.3	0.6	1.0	-1.0	-0.6	-0.7
Chest pain or discomfort	0.3	0.4	0.9	0.3	-0.9	-0.5
Had major operations	0.5	0.5	1.0	-0.7	0.1	1.0
Age at last live birth	0.1	0.2	0.5	0.3	-0.1	-0.7
Family relationship satisfaction	0.3	0.3	0.9	-0.9	0.2	-0.2
Leg pain on walking	0.8	1.0	1.3	0.8	1.0	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.8	-0.5	-0.5	1.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	-0.1	0.1	-1.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.0	0.1	0.0	1.4
Medication: Aspirin	2.0	2.6	5.1	-0.6	1.5	2.3
Supplements: Vitamin C	0.5	0.6	1.0	1.0	-0.4	-0.7
Knee pain experienced in last month	0.5	0.7	1.5	0.6	0.4	-1.2
Hypertension (Self-reported)	0.1	0.2	0.6	-0.1	0.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	5.2	-1.2	-2.3	-0.7
Illnesses of father: Heart disease	0.4	0.5	1.1	0.7	1.0	-0.1
Illnesses of siblings: Diabetes	1.2	1.5	2.3	-1.4	0.6	-1.5
Smoking status: Previous	1.0	1.5	3.2	0.8	0.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	3.6	1.9	1.2	-1.9
Whole body fat-free mass	1.2	6.6	18.1	1.3	0.2	-4.3
Leg fat-free mass (right)	1.1	5.7	15.3	1.3	-0.2	-3.9
Arm fat percentage (left)	0.3	1.2	3.2	-0.1	-0.7	-1.8
Average weekly red wine intake	1.1	1.6	2.8	1.4	-0.2	1.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.5	0.2	0.3
Mood swings	0.2	0.3	0.8	-0.9	-0.3	0.1
Loneliness, isolation	0.1	0.1	0.2	0.0	-0.3	-0.5
Long-standing illness, disability or infirmity	0.9	1.3	3.5	0.4	0.6	-1.9
Ever had bowel cancer screening	0.4	0.4	1.2	1.1	-0.1	0.2
Diabetes diagnosed by doctor	0.4	0.7	1.1	-0.9	1.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	5.2	-2.3	-1.6	0.0
Friendships satisfaction	1.0	1.3	2.7	1.0	1.6	-0.3
Qualifications: nursing, teaching	0.3	0.5	1.3	0.1	1.1	-0.4
Commuting to job workplace: Walk	0.5	0.5	0.8	0.7	0.6	0.9
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.8	0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.8	0.1	-1.4	1.9
Medication for cholesterol	0.2	0.3	0.4	0.6	0.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.4	-0.5	1.5	-2.3
Back pain experienced in last month	0.9	1.3	2.2	1.5	0.7	1.1
Mineral and other dietary supplements	0.3	0.4	0.6	-0.3	0.8	0.7
Breast cancer (self-reported)	0.8	1.0	2.3	-0.8	-0.3	-1.5
Asthma (self-reported)	2.9	5.7	12.0	3.5	2.2	-0.1
Osteoporosis (self-reported)	3.2	4.0	7.2	-2.2	-2.7	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.7	-0.1	0.3
Medication: Aspirin	2.0	2.6	5.2	-1.0	1.2	2.3
Medication: Gliclazide	1.5	1.7	4.2	-0.0	0.9	-2.0
Illnesses of father: None of the above (group 1)	0.4	0.6	1.4	-0.0	-0.5	-1.2
Smoking status: Current	0.3	0.4	1.3	0.0	-1.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	-0.3	-0.9	0.7
Whole body water mass	1.2	6.6	17.6	1.4	0.3	-4.2
Leg predicted mass (right)	1.0	5.5	14.8	1.3	-0.1	-3.8
Arm fat mass (left)	0.7	3.1	9.0	0.3	-0.3	-3.0
Number of self-reported non-cancer illnesses	0.4	0.8	1.2	1.1	1.0	0.4
Average weekly champagne plus white wine intake	0.8	1.1	1.5	-0.9	-1.2	1.0
Miserableness	0.0	0.0	0.1	0.1	-0.2	0.3
Guilty feelings	1.4	2.2	5.2	-0.9	0.7	-2.3
Wears glasses or contact lenses	4.8	5.5	8.8	2.8	3.0	0.0
Ever taken oral contraceptive pill	2.0	2.3	6.1	-2.5	0.8	-0.3
Hearing aid user	1.1	1.3	3.8	-1.9	0.2	0.2
Mother’s age at death	0.1	0.1	0.2	-0.4	-0.3	-0.2
Financial situation satisfaction	1.6	2.0	2.8	-1.7	-1.7	0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.3	-0.9	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.1	-0.4	-0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.8	-0.4	0.3
Medication: Blood pressure	0.4	0.8	1.2	-1.1	-0.7	0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.0	0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.3	-0.5	-1.2	-0.2
High cholesterol (Self-reported)	0.8	1.4	4.0	-0.2	2.0	0.3
Medication: Bendroflumethiazide	0.4	0.7	0.8	-0.7	0.8	0.9
Medication: Paracetamol	0.6	0.9	1.6	0.1	1.1	-1.3
Medication: Lisinopril	1.1	1.5	3.3	1.0	-0.3	1.8
Medication: Atorvastatin	0.7	0.9	2.0	-1.4	0.6	0.6
Illnesses of father: High blood pressure	0.5	0.6	0.8	-0.6	-0.8	-0.9
Alcohol drinker status: Never	2.7	3.2	6.9	-2.6	-1.7	-0.2
Ever smoked	0.8	1.4	3.0	-0.2	-1.1	1.7
Basal metabolic rate	1.3	7.1	19.6	1.3	0.3	-4.4
Leg fat percentage (left)	0.7	2.6	7.3	-0.7	0.0	-2.7
Arm fat-free mass (left)	1.2	6.3	17.6	1.1	0.5	-4.2
Number of operations (self-reported)	0.1	0.1	0.3	0.1	0.5	-0.1
Average weekly beer plus cider intake	1.9	2.7	4.5	-1.8	-2.1	0.7
Irritability	0.9	1.5	4.0	-0.6	-0.5	2.0
Risk taking	0.6	0.9	1.3	1.2	0.5	-1.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.3	0.8	-0.2
Fractured/broken bones in last 5 years	1.1	1.4	2.4	-1.6	-1.2	0.5
Age started oral contraceptive pill	1.3	1.6	2.5	-1.6	-0.6	-1.4
Diastolic blood pressure, automated reading	0.2	0.6	0.9	-1.0	-0.8	0.2
Ever depressed for a whole week	0.8	1.0	1.4	1.0	1.2	-0.8
Unable to work because of sickness or disability	0.7	0.9	1.3	-1.1	0.5	-1.0
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.2	0.2	0.2
Myopia	1.2	1.8	5.3	-0.0	0.4	-2.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.4	0.2	-0.6	-1.8
Cholesterol lowering medication	0.2	0.3	0.7	-0.8	0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.3	0.3	-0.7
Pain experienced in last month	0.1	0.2	0.5	-0.7	0.4	-0.1
Supplements: Calcium	0.4	0.4	1.1	-0.3	-0.2	-1.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	0.9	0.5	0.4
Heart attack/myocardial infarction (self-reported)	2.4	3.1	5.5	-1.6	-1.1	2.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.0	0.8	1.4	-1.4
Heart disease (siblings)	1.1	1.4	1.9	1.4	1.4	-0.5
Alcohol drinker status: Previous	0.8	0.9	1.9	-1.4	0.1	-0.9
Pack years of smoking	0.6	0.9	1.7	0.9	1.3	0.1
Impedance of whole body	0.2	1.1	2.4	-1.6	-0.1	0.9
Leg fat mass (left)	0.9	3.5	10.4	-0.3	-0.1	-3.2
Arm predicted mass (left)	1.1	5.8	16.5	1.0	0.3	-4.1