TWAS hub - TMEM121

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1070	0.0378	6.1e-05	0.100	NA	0.061	NA	0.076	1.4e-07	NA	3.9e-05	NA	4.9e-06
2	GTEx	Whole Blood	0.0810	0.0280	4.4e-05	0.100	NA	0.073	NA	0.088	1.6e-09	NA	2.7e-07	NA	1.8e-08
3	METSIM	Adipose	0.0425	0.0191	1.7e-03	0.025	0.014	0.011	0.014	0.009	1.1e-04	0.0029	8.2e-03	0.0026	1.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Supplements: Glucosamine	9.1	11.8	14.1	-3.0	3.8	3.5
Arm predicted mass (right)	6.5	33.1	36.3	5.2	-6.0	-6.0
Seen doctor (GP) for nerves, anxiety, tension or depression	6.4	9.8	11.0	2.9	-3.3	-3.2
Arm fat-free mass (right)	6.1	31.3	34.6	5.0	-5.9	-5.8
Hypothyroidism (self reported)	6.0	13.7	16.2	-3.7	4.0	3.4
Arm predicted mass (left)	5.8	29.7	33.1	4.9	-5.8	-5.7
Supplements: Calcium	5.5	6.0	6.9	-2.3	2.5	2.6
Arm fat-free mass (left)	5.4	27.2	30.1	4.7	-5.5	-5.4
Mineral and other dietary supplements	5.0	6.7	8.4	2.2	-2.9	-2.6
Ever taken oral contraceptive pill	4.9	5.4	8.8	-1.8	2.1	3.0
Forced expiratory volume in 1-second (FEV1), predicted	4.8	9.9	10.6	3.1	-3.3	-3.1
Trunk fat-free mass	4.6	26.4	29.1	4.7	-5.3	-5.4
Trunk predicted mass	4.6	26.2	28.6	4.7	-5.3	-5.3
Depressed Affect (Nagel 2018)	4.3	9.0	12.4	2.8	-2.6	-3.5
Whole body fat-free mass	4.3	24.6	29.2	4.3	-5.1	-5.4
Illnesses of father: None of the above (group 1)	4.3	5.3	7.2	-2.1	2.1	2.7
Standing height	4.2	42.1	47.9	6.3	-6.9	-6.2
Whole body water mass	4.2	24.1	28.3	4.3	-5.1	-5.3
Frequency of depressed mood in last 2 weeks	4.1	5.7	6.4	2.3	-2.5	-2.4
Miserableness	4.1	7.2	9.8	2.6	-2.2	-3.1
Basal metabolic rate	4.1	22.9	28.0	4.1	-4.9	-5.3
Eye problems/disorders: Cataract	4.0	4.7	7.6	-1.6	1.9	2.8
Ever unenthusiastic/disinterested for a whole week	3.9	4.8	5.5	2.3	-2.3	-1.9
Loneliness, isolation	3.8	5.2	7.3	2.7	-2.2	-1.9
Height	3.7	71.2	77.8	8.8	-8.8	-7.7
Verbal and Numeric Reasoning (VNR)	3.5	8.5	10.4	2.7	-2.8	-3.2
Heel T-Score	3.5	27.5	30.2	5.2	-5.0	-5.5
Neuroticism (2016)	3.4	5.0	5.6	2.2	-2.4	-2.1
Hypothyroidism/myxoedema (self-reported)	3.4	6.5	8.5	-2.4	2.9	2.3
Lupus	3.3	5.1	7.2	-1.6	2.7	2.3
Number of full sisters	3.3	4.0	4.7	1.8	-2.2	-2.0
Chest pain or discomfort	3.3	4.8	6.5	2.5	-2.2	-1.7
Leg fat-free mass (right)	3.3	17.6	24.8	3.3	-4.1	-5.0
Osteoporosis (self-reported)	3.3	4.1	6.3	-2.5	2.1	1.3
Leg predicted mass (right)	3.3	17.4	24.6	3.2	-4.1	-5.0
Alzheimer’s Disease (including proxy)	3.1	4.4	6.3	-2.5	2.4	1.2
Leg fat-free mass (left)	3.1	16.2	22.3	3.2	-4.0	-4.7
Townsend deprivation index at recruitment	3.1	4.4	5.1	2.0	-2.0	-2.3
Stomach or abdominal pain in last month	3.1	3.9	5.9	1.8	-1.5	-2.4
Medication: Levothyroxine sodium	3.0	5.0	5.7	-2.0	2.3	2.4
Leg predicted mass (left)	3.0	16.1	22.3	3.2	-4.0	-4.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	4.6	2.1	-2.1	-1.7
Sitting height	2.9	20.9	25.5	4.5	-5.0	-4.1
High blood pressure (mother)	2.8	3.9	4.3	1.8	-2.1	-2.0
Glaucoma (self-reported)	2.8	3.3	4.2	1.9	-2.0	-1.5
Mood swings	2.8	5.1	6.2	1.9	-2.4	-2.5
Mother’s age at death	2.8	3.5	3.9	2.0	-1.9	-1.8
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.6	1.3	-1.5	-2.4
Medication: Ibuprofen	2.7	3.3	4.2	1.8	-2.1	-1.5
Ever had prostate specific antigen (PSA) test	2.7	3.1	4.3	-2.1	1.7	1.4
Age started oral contraceptive pill	2.6	3.3	4.0	-2.0	1.5	1.9
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	4.3	1.9	-2.1	-1.4
Emphysema/chronic bronchitis	2.5	2.8	3.8	1.3	-1.7	-1.9
Angina	2.4	3.1	4.1	2.0	-1.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	3.3	1.8	-1.8	-1.8
Wheeze or whistling in the chest in last year	2.4	4.2	4.7	2.2	-2.1	-1.8
Illnesses of father: Heart disease	2.4	3.3	3.8	1.9	-1.6	-1.9
Depression (Nagel 2018)	2.3	3.5	4.6	1.7	-1.8	-2.1
Commuting to job workplace: Car/motor vehicle	2.3	2.6	3.0	-1.7	1.7	1.3
Irritability	2.3	4.0	4.6	1.9	-2.0	-2.1
Lung FVC	2.2	11.1	13.4	-3.2	3.1	3.7
Weight	2.2	10.9	15.7	2.5	-3.3	-4.0
Financial situation satisfaction	2.2	2.7	3.4	1.7	-1.8	-1.3
Hayfever, allergic rhinitis or eczema	2.1	4.6	6.3	2.5	-2.2	-1.5
Angina (self-reported)	2.1	2.7	3.9	2.0	-1.7	-1.1
Migraine (self-reported)	2.1	2.6	3.4	1.8	-1.8	-1.2
Bipolar Disorder (2018)	2.0	3.1	6.2	1.8	0.0	-2.5
Neuroticism score	2.0	4.2	5.3	2.2	-2.3	-1.5
Father’s age at death	2.0	2.7	3.7	-1.7	1.9	1.3
Systolic Blood Pressure	1.9	9.7	11.3	2.9	-3.1	-3.4
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	5.8	2.4	-2.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.2	3.7	1.7	-1.7	-1.9
Hearing aid user	1.9	2.1	3.6	-1.3	1.0	1.9
Number of operations (self-reported)	1.9	2.8	4.0	-1.5	1.5	2.0
Diabetes (mother)	1.8	2.3	2.7	-1.5	1.7	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.2	5.4	2.3	-2.2	-1.5
Comparative height size at age 10	1.8	10.1	12.3	3.3	-3.5	-2.7
Knee pain experienced in last month	1.8	2.8	3.2	-1.6	1.6	1.8
Mean Putamen Volume	1.7	1.9	4.2	1.3	0.0	-2.1
Fed-up feelings	1.7	3.1	4.2	2.0	-1.8	-1.5
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	2.7	1.6	-1.2	-1.4
Past tobacco smoking	1.7	3.0	5.3	1.1	-1.6	-2.3
Prospective memory result	1.7	2.1	2.6	-1.2	1.6	1.5
Heart disease (mother)	1.7	2.1	2.4	1.4	-1.3	-1.6
Supplements: Fish oil (including cod liver oil)	1.7	2.2	2.9	-1.1	1.7	1.5
Bipolar Disorder or Schizophrenia	1.6	3.8	6.8	2.6	0.0	-2.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	2.7	-1.4	1.7	1.2
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	2.6	-1.3	1.6	1.3
Smoking status: Previous	1.6	2.4	4.0	-1.1	1.4	2.0
Ever had bowel cancer screening	1.6	1.8	2.9	0.9	-1.3	-1.7
Ever smoked	1.6	2.9	4.6	-1.2	1.7	2.1
Neuroticism (Nagel 2018)	1.5	3.5	4.0	1.7	-1.9	-2.0
Neuroticism	1.5	3.7	4.2	2.0	-2.0	-1.7
Medication: Atenolol	1.5	1.8	2.3	1.5	-1.3	-1.2
Pack years adult smoking proportion	1.4	2.2	4.4	1.0	-1.1	-2.1
Commuting to job workplace: Public transport	1.4	1.7	2.7	1.6	-1.3	-0.8
Ever depressed for a whole week	1.4	1.7	2.7	1.6	-1.4	-0.6
Blood Eosinophil Count	1.3	9.8	11.4	-3.1	3.4	2.9
Allergy or Eczema	1.3	3.4	5.1	2.3	-2.0	-1.1
Medication: Omeprazole	1.3	1.5	3.2	0.7	-0.9	-1.8
Pulse rate, automated reading	1.3	4.3	5.3	-2.3	1.9	2.0
Illnesses of siblings: Diabetes	1.3	1.6	2.2	-1.2	1.5	1.1
Commuting to job workplace: Walk	1.3	1.4	2.7	0.9	-0.9	-1.6
Wears glasses or contact lenses	1.3	1.5	1.9	-1.1	1.1	1.4
Illnesses of father: High blood pressure	1.3	1.6	1.7	1.3	-1.2	-1.3
Serious illness, injury or assault to yourself	1.2	1.5	1.8	1.4	-1.3	-1.0
Pain all over the body in last month	1.2	1.3	1.8	-0.6	1.2	1.4
Hair/balding pattern: Pattern 4	1.2	2.8	3.3	1.8	-1.5	-1.8
Peak expiratory flow (PEF)	1.2	2.7	2.9	1.6	-1.6	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	2.2	1.1	-1.5	-0.6
Average weekly beer plus cider intake	1.2	1.7	2.2	1.5	-1.1	-1.3
Leg fat mass (left)	1.2	4.6	8.6	1.3	-1.8	-2.9
Alzheimer’s Disease (in mother)	1.1	1.3	2.0	-1.3	1.4	0.5
Schizophrenia (2014)	1.1	2.4	4.9	2.2	0.0	-1.5
Trunk fat mass	1.1	4.6	8.5	1.4	-1.9	-2.9
Had menopause	1.1	1.4	2.2	-1.5	1.2	0.8
Breastfed as a baby	1.1	1.4	1.9	1.4	-1.0	-1.1
Comparative body size at age 10	1.1	3.1	4.2	-2.1	1.8	1.4
Breast cancer (self-reported)	1.1	1.3	2.0	0.6	-1.2	-1.4
Basal cell carcinoma (self-reported)	1.1	1.3	1.7	-1.3	1.1	1.0
Intelligence (Savage-Jansen 2018)	1.0	3.2	4.0	1.7	-1.7	-2.0
Impedance of arm (right)	1.0	4.9	6.0	-1.8	2.3	2.4
Time employed in main current job	1.0	1.2	1.8	-1.1	1.3	0.7
Length of working week for main job	1.0	1.1	2.6	-0.8	1.6	0.3
High blood pressure (siblings)	1.0	1.4	1.7	1.3	-1.0	-1.3
Exposure to tobacco smoke outside home	1.0	1.4	1.9	-1.2	1.4	0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.3	-1.0	1.1	1.1
Medication: Seretide 50 evohaler	1.0	1.1	1.7	-1.3	1.1	0.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	1.4	-1.2	1.0	1.2
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.0	-0.9	0.9	1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	1.5	1.2	-1.1	-1.2
Pack years of smoking	1.0	1.4	3.2	0.6	-0.8	-1.8
Age when periods started (menarche)	0.9	2.2	2.6	1.3	-1.6	-1.5
Forced vital capacity (FVC)	0.9	3.4	4.7	2.2	-2.0	-1.2
Shortness of breath walking on level ground	0.9	1.1	1.9	-1.4	0.9	0.7
Eye problems/disorders: None of the above	0.9	1.1	3.1	-0.1	-0.2	-1.8
Whole body fat mass	0.9	3.7	7.2	1.1	-1.6	-2.7
Leg fat mass (right)	0.9	3.4	6.5	1.1	-1.6	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.7	1.3	-0.9	-1.3
Ulcerative Colitis (UC)	0.8	1.5	2.0	1.0	-1.2	-1.4
Medication: Metformin	0.8	1.1	1.4	1.1	-0.7	-1.2
Heart attack	0.8	1.0	1.1	1.1	-0.9	-1.1
Allergy	0.8	1.8	2.3	-1.5	1.4	1.1
Number of live births	0.8	1.1	2.2	-0.4	0.9	1.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	3.4	1.8	-1.8	-1.2
Pulse rate	0.8	1.3	2.8	-1.7	0.9	0.6
Supplements: Vitamin C	0.8	1.0	1.4	-0.7	1.0	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	0.9	-1.3	-0.7
Schizophrenia (2018)	0.7	1.4	3.6	1.9	0.0	-0.8
Alzheimer’s Disease (in father)	0.7	0.8	1.6	-1.2	0.7	0.4
Average weekly spirits intake	0.7	0.8	1.2	-0.8	0.7	1.1
Financial difficulties in last 2 years	0.7	1.0	1.2	-0.8	1.1	1.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.3	1.2	-1.1	-0.4
Fluid intelligence score	0.7	1.4	2.1	0.9	-1.2	-1.4
Illnesses of siblings	0.7	0.9	1.3	-1.1	0.9	0.8
Hip circumference	0.7	3.0	6.5	0.8	-1.3	-2.6
Lung cancer (father)	0.7	0.8	1.3	0.9	-1.1	-0.4
Age at first live birth	0.7	1.3	1.6	-1.2	0.9	1.3
Health satisfaction	0.7	0.9	1.0	1.0	-0.9	-1.0
Medication: Allopurinol	0.7	1.0	1.1	1.1	-1.0	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.3	0.3	-0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.5	-0.8	1.2	1.6
Arm fat mass (left)	0.7	3.0	6.4	0.8	-1.4	-2.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-1.0	0.6	1.1
Chronotype (morning person)	0.6	1.3	2.0	-1.4	1.3	0.4
Vitamin and mineral supplements	0.6	0.8	1.2	0.8	-1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	0.7	-1.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.0	1.0	-1.0	-1.0
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	-0.7	0.7	1.2
Falls in the last year	0.6	0.8	1.1	0.7	-1.0	-0.9
Medication: Lansoprazole	0.6	0.7	0.8	-0.8	0.9	0.7
Tense / ‘highly strung’	0.6	1.0	1.8	1.1	-1.3	0.1
Blood clot in the leg (DVT)	0.6	0.7	1.3	-0.8	1.2	-0.4
Prostate Cancer	0.5	0.7	1.0	0.7	-0.7	-1.0
Systolic blood pressure, automated reading	0.5	1.3	2.6	0.8	-0.9	-1.6
Current tobacco smoking	0.5	0.8	1.8	1.3	-0.6	-0.5
Relative age voice broke	0.5	0.8	1.0	-0.9	0.7	1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.9	-0.5	1.0	0.7
Qualifications: CSEs or equivalent	0.5	0.7	0.9	-0.7	0.9	0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	0.4	-0.7	-1.1
Waist circumference	0.5	1.7	4.3	0.2	-0.9	-2.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	-0.8	1.1	0.3
Impedance of arm (left)	0.5	2.3	2.9	-1.1	1.6	1.7
Arm fat mass (right)	0.5	2.2	4.9	0.6	-1.1	-2.2
Birth weight of first child	0.5	0.8	2.2	-0.0	0.5	1.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.9	0.8	-1.0	-0.2
Worry too long after embarrassment	0.5	0.8	1.3	1.1	-1.0	0.3
Age at last live birth	0.5	0.7	0.7	-0.8	0.8	0.8
Back pain experienced in last month	0.5	0.8	1.3	-1.1	0.5	0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	0.2	-0.4	-1.3
Crohns Disease (2017)	0.4	0.9	1.4	-0.5	1.1	1.2
Age at First Birth	0.4	0.5	0.8	-0.9	0.9	0.4
Blood Platelet Count	0.4	4.9	5.2	2.3	-2.2	-2.2
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	0.3	-0.8	-0.8
Multivitamins +/- minerals	0.4	0.5	0.7	-0.6	0.6	0.9
Number of incorrect matches in round	0.4	0.7	0.9	-0.8	0.8	0.9
Qualifications: None of the above	0.4	0.8	1.3	-1.1	1.0	0.3
Arm fat percentage (right)	0.4	1.4	2.7	-1.6	1.3	-0.1
Pulse wave reflection index	0.4	0.4	1.0	-0.5	0.4	1.0
Neck or shoulder pain in last month	0.4	0.6	1.6	0.2	-0.2	-1.3
Mean time to correctly identify matches	0.4	0.7	0.8	-0.9	0.8	0.8
Family relationship satisfaction	0.4	0.5	0.9	0.8	-0.9	-0.1
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	0.8	-0.7	0.2
Alcohol drinker status: Never	0.4	0.4	0.7	-0.8	0.8	0.1
Cholesterol lowering medication	0.4	0.6	0.9	0.5	-0.7	-1.0
Breast Cancer	0.3	0.6	1.8	-0.2	-0.1	-1.4
Blood White Count	0.3	2.0	3.1	-1.4	1.8	1.0
Smoking Status	0.3	0.7	1.2	-0.1	0.9	1.1
Sensitivity / hurt feelings	0.3	0.5	1.3	0.2	-0.4	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.6	0.4	0.7
Average weekly fortified wine intake	0.3	0.3	0.7	-0.4	0.8	0.4
Mouth/teeth dental problems	0.3	0.5	0.7	0.6	-0.8	-0.7
Diabetes (self-reported)	0.3	0.5	1.0	1.0	-0.5	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.6	0.9	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	0.6	-0.7	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	-0.5	1.0	0.7
Suffer from ‘nerves’	0.3	0.4	0.7	0.5	-0.8	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-0.5	0.9	-0.4
Heart disease (siblings)	0.3	0.4	0.8	0.9	-0.4	-0.3
Ovarian Cancer	0.2	0.3	0.9	-0.1	-0.1	1.0
Crohns Disease (2012)	0.2	0.3	0.7	0.9	0.0	-0.2
Respiratory disease	0.2	0.5	0.8	-0.7	0.3	0.9
Lung FEV1/FVC ratio	0.2	1.0	1.4	-0.7	1.1	1.2
Trunk fat percentage	0.2	0.9	2.2	0.1	-0.5	-1.5
Body mass index (BMI)	0.2	0.6	1.8	-0.3	-0.2	-1.3
Nervous feelings	0.2	0.5	0.8	0.8	-0.9	0.0
Happiness	0.2	0.2	0.3	0.1	-0.6	0.5
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.3	0.8	0.2
Illnesses of mother	0.2	0.3	0.4	-0.4	0.6	0.7
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	-0.1	-0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.7	0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.6	-0.7	-0.4
Number of children fathered	0.2	0.2	0.3	-0.4	0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.7	-0.2	-0.4
Arm fat percentage (left)	0.2	0.9	1.5	-1.2	0.8	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.4	-0.5	0.6	0.4
Friendships satisfaction	0.2	0.3	0.8	-0.1	0.2	0.9
Smoking status: Current	0.2	0.3	0.8	0.9	-0.1	-0.1
Guilty feelings	0.2	0.3	0.5	0.6	-0.7	0.1
Medication: Blood pressure	0.2	0.5	0.7	0.8	-0.9	-0.2
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.5	0.7	0.5
Medication: Lisinopril	0.2	0.2	0.6	-0.2	-0.1	0.8
Leg fat percentage (left)	0.2	0.6	1.8	-0.1	-0.2	-1.3
Risk taking	0.2	0.3	0.8	-0.1	0.9	0.3
Unable to work because of sickness or disability	0.2	0.2	0.3	-0.5	0.5	0.3
Myopia	0.2	0.3	0.8	0.2	-0.3	-0.9
Impedance of whole body	0.2	0.8	2.0	-0.1	0.6	1.4
Worry (Nagel 2018)	0.1	0.2	0.5	0.4	-0.7	-0.3
Reaction Time	0.1	0.2	0.3	0.4	-0.5	-0.6
HbA1C	0.1	0.2	0.3	-0.0	0.6	0.3
Blood Red Count	0.1	1.1	2.6	0.8	-1.6	-0.3
BMI	0.1	0.8	2.0	0.1	-0.5	-1.4
Waist Hip Ratio (WHR)	0.1	0.3	0.7	-0.8	0.3	0.0
Tanning	0.1	1.0	1.7	1.0	-1.3	-0.5
Hand grip strength (left)	0.1	0.3	0.8	-0.2	0.1	0.9
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	-0.4	-0.0
Supplements: Zinc	0.1	0.1	0.2	-0.0	0.3	0.4
Severe depression (siblings)	0.1	0.2	0.2	0.2	-0.5	-0.4
Impedance of leg (right)	0.1	0.7	1.6	0.7	-0.1	1.3
Taking other prescription medications	0.1	0.1	0.1	-0.3	0.3	-0.2
High blood pressure	0.1	0.1	0.3	-0.5	0.4	-0.1
Impedance of leg (left)	0.1	0.7	1.4	1.2	-0.6	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.6	-0.1	0.3
Had other major operations	0.1	0.2	0.3	0.5	-0.3	-0.4
Medication: Ramipril	0.1	0.1	0.1	-0.2	0.4	-0.2
Worrier / anxious feelings	0.1	0.3	0.4	0.2	-0.7	0.6
Noisy workplace	0.1	0.2	0.3	-0.6	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.2	-0.2	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.3	-0.0	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	0.6	-0.6	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.3	0.1	-0.5
Loud music exposure frequency	0.1	0.1	0.2	-0.1	0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.4	0.1	-0.0	-0.6
Headache pain in last month	0.1	0.2	0.4	-0.6	0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.4	-0.6	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	0.7	-0.7	-0.1
Body fat percentage	0.1	0.4	1.1	-0.3	-0.1	-1.1
Leg fat percentage (right)	0.1	0.3	0.9	-0.3	0.1	-0.9
Pulse wave peak to peak time	0.1	0.2	0.2	0.5	0.5	-0.1
Medication: Blood pressure	0.1	0.2	0.2	-0.3	0.4	-0.5
Alcohol intake frequency.	0.1	0.2	0.6	-0.1	0.1	-0.8
Had major operations	0.1	0.1	0.3	0.2	-0.2	0.6
Leg pain on walking	0.1	0.1	0.1	-0.4	-0.1	0.3
Medication: Aspirin	0.1	0.1	0.1	-0.3	0.2	0.3
Average weekly red wine intake	0.1	0.1	0.2	-0.1	0.5	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	-0.0	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.3	0.7	0.1
Qualifications: nursing, teaching	0.1	0.2	0.6	0.0	-0.0	-0.8
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.2	-0.6	0.1
Medication: Aspirin	0.1	0.1	0.1	-0.4	0.3	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.3	0.6	0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.7	0.4	0.1
Pain experienced in last month	0.1	0.2	0.3	-0.2	0.5	0.4
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	-0.1	0.1	-0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.1	-0.3	0.1	-0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.0	0.4	0.2
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.1	0.1	0.2	0.0	-0.4
Cardiovascular Disease	0.0	0.0	0.0	0.2	-0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	-0.1	0.3	0.1
Hair Pigment	0.0	0.9	1.4	0.9	-0.7	-1.2
Number of treatments/medications taken	0.0	0.0	0.0	0.0	0.0	0.0
Relative age of first facial hair	0.0	0.1	0.2	0.2	-0.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.0	0.1	0.1	-0.0	0.3	0.2
Medication for hormone replacement therapy	0.0	0.1	0.1	-0.4	0.1	0.1
Medication: Co-codamol	0.0	0.0	0.0	-0.2	-0.0	-0.2
Diabetes (father)	0.0	0.0	0.0	0.1	-0.2	-0.1
Hand grip strength (right)	0.0	0.1	0.2	0.2	-0.4	-0.2
Maternal smoking around birth	0.0	0.0	0.1	-0.1	-0.3	0.1
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	0.0	0.4
Medication: Simvastatin	0.0	0.0	0.0	0.2	-0.1	0.0
Asthma	0.0	0.1	0.1	0.1	-0.3	0.4
Depression (self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.1
Medication: Paracetamol	0.0	0.1	0.2	0.1	-0.4	0.2
Gout (self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.1
Medication: Amlodipine	0.0	0.0	0.1	-0.1	0.3	0.1
Birth weight	0.0	0.0	0.1	-0.0	-0.3	0.2
Number of full brothers	0.0	0.1	0.1	0.3	-0.1	-0.3
Qualifications: College or University degree	0.0	0.1	0.3	0.0	-0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.0	-0.0	-0.2
Overall health rating	0.0	0.1	0.1	-0.2	0.4	-0.1
Hypertension (Self-reported)	0.0	0.0	0.1	-0.1	0.0	-0.2
Medication for cholesterol	0.0	0.0	0.1	0.2	-0.0	0.3
Asthma (self-reported)	0.0	0.1	0.3	-0.1	-0.0	0.5
Medication: Gliclazide	0.0	0.0	0.1	0.3	-0.2	-0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.0	-0.1	0.1
High cholesterol (Self-reported)	0.0	0.0	0.1	0.3	-0.2	-0.1
Medication: Paracetamol	0.0	0.1	0.2	0.1	-0.4	0.2
Medication: Atorvastatin	0.0	0.0	0.1	0.3	0.1	-0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.1	0.1	0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.1	-0.1	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.0	0.1	0.6
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.0	0.1	-0.2

Hub : Genes

TMEM121

Models

Trait associations