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chr15:39,530,508-42,749,023

Best TWAS P=8.28e-24 · Best GWAS P=2.07e-17 conditioned to 0.246

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHP	0.06	0.01	blup	54	0.03	4.7e-04	-7.8	10.1	8.3e-24	-0.80	0.01	0.96	TRUE
7	GTEx	Artery Aorta	EIF2AK4	0.31	0.08	enet	29	0.17	1.8e-09	-2.7	5.4	7.4e-08	0.05	0.16	0.21	TRUE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC729082	0.06	0.01	enet	6	0.03	3.3e-04	-6.4	8.3	7.2e-17	-0.85	0.02	0.42	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC729082	0.02	0.01	blup	44	0.02	2.9e-04	-5.9	8.3	1.4e-16	-0.69	0.02	0.97	FALSE
5	GTEx	Adipose Visceral Omentum	OIP5-AS1	0.23	0.16	lasso	10	0.11	2.8e-06	-7.8	-8.2	2.1e-16	0.66	0.48	0.51	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	OIP5-AS1	0.17	0.19	enet	17	0.22	4.3e-12	-7.4	-7.8	5.7e-15	0.65	0.61	0.39	FALSE
33	GTEx	Cells Transformed fibroblasts	OIP5-AS1	0.28	0.32	lasso	2	0.32	3.5e-24	-7.8	-7.8	5.8e-15	0.61	0.23	0.77	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NUSAP1	0.24	0.31	lasso	6	0.22	2.0e-06	-7.4	-7.8	7.5e-15	0.64	0.30	0.67	FALSE
45	GTEx	Lung	OIP5-AS1	0.09	0.08	enet	14	0.12	2.8e-09	-6.5	-7.8	8.4e-15	0.82	0.40	0.60	FALSE
6	GTEx	Adrenal Gland	OIP5-AS1	0.17	0.16	lasso	3	0.16	2.6e-06	-7.4	-7.7	1.3e-14	0.56	0.58	0.29	FALSE
35	GTEx	Colon Sigmoid	OIP5-AS1	0.21	0.27	lasso	3	0.25	3.3e-09	-7.8	-7.7	1.3e-14	0.61	0.49	0.51	FALSE
9	GTEx	Artery Coronary	OIP5-AS1	0.12	0.13	lasso	2	0.14	2.3e-05	-7.8	-7.7	1.7e-14	0.60	0.31	0.54	FALSE
20	GTEx	Brain Frontal Cortex BA9	NDUFAF1	0.55	0.37	lasso	8	0.40	1.6e-11	-7.8	7.6	2.4e-14	-0.61	0.48	0.52	FALSE
46	GTEx	Muscle Skeletal	NDUFAF1	0.44	0.56	enet	31	0.60	3.0e-73	-6.6	7.6	3.0e-14	-0.63	1.00	0.00	FALSE
37	GTEx	Esophagus Gastroesophageal Junction	OIP5-AS1	0.18	0.10	lasso	7	0.11	8.9e-05	-7.8	-7.6	3.7e-14	0.67	0.40	0.45	FALSE
39	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	-6.7	7.6	4.2e-14	-0.83	0.55	0.45	FALSE
8	GTEx	Artery Aorta	OIP5-AS1	0.16	0.21	enet	26	0.23	5.2e-13	-5.8	-7.5	4.8e-14	0.68	0.93	0.07	FALSE
84	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EXD1	0.33	0.04	enet	12	0.12	6.1e-05	-8.5	-7.5	5.3e-14	0.81	0.00	0.92	FALSE
24	GTEx	Brain Nucleus accumbens basal ganglia	NUSAP1	0.36	0.32	lasso	6	0.26	1.5e-07	-7.8	-7.5	5.6e-14	0.64	0.49	0.50	FALSE
36	GTEx	Colon Transverse	OIP5-AS1	0.13	0.14	lasso	5	0.15	1.8e-07	-7.8	-7.5	6.0e-14	0.59	0.58	0.41	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NDUFAF1	0.23	0.15	lasso	3	0.13	3.7e-06	-7.4	-7.5	6.0e-14	0.61	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC729082	0.04	0.07	lasso	1	0.06	5.5e-07	-7.4	7.4	9.7e-14	-0.58	0.01	0.99	FALSE
48	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	-7.4	-7.4	1.1e-13	0.77	0.55	0.45	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NUSAP1	0.20	0.24	bslmm	311	0.24	4.6e-29	-7.3	-7.4	1.4e-13	0.58	0.86	0.14	FALSE
63	METSIM	Adipose	NUSAP1	0.03	0.03	lasso	6	0.02	4.2e-04	-7.3	-7.3	2.1e-13	0.55	0.48	0.31	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFAF1	0.03	0.04	lasso	3	0.04	3.2e-05	-7.4	7.3	2.1e-13	-0.57	0.01	0.99	FALSE
13	GTEx	Brain Cerebellar Hemisphere	NDUFAF1	0.20	0.23	lasso	6	0.22	2.2e-06	-6.6	7.3	2.5e-13	-0.58	0.56	0.31	FALSE
21	GTEx	Brain Hippocampus	NUSAP1	0.30	0.25	enet	14	0.26	1.0e-06	-7.4	-7.3	2.8e-13	0.65	0.19	0.59	FALSE
51	GTEx	Pancreas	NDUFAF1	0.41	0.39	enet	20	0.42	2.7e-19	-6.6	-7.2	4.2e-13	0.56	0.97	0.03	FALSE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NDUFAF1	0.18	0.21	blup	28	0.22	5.4e-09	-6.6	-7.2	4.8e-13	0.54	0.04	0.96	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INO80	0.07	0.04	blup	40	0.06	1.2e-03	-5.2	-7.2	6.1e-13	0.79	0.04	0.54	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXD1	0.04	0.04	lasso	3	0.04	8.1e-06	-6.8	7.2	6.3e-13	-0.94	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	NDUFAF1	0.32	0.38	enet	11	0.39	1.2e-39	-6.6	-7.2	8.5e-13	0.54	0.35	0.65	FALSE
26	GTEx	Brain Putamen basal ganglia	NUSAP1	0.38	0.30	lasso	20	0.34	9.1e-09	-6.6	-7.1	9.7e-13	0.51	0.69	0.29	FALSE
14	GTEx	Brain Cerebellum	OIP5	0.16	0.09	lasso	4	0.16	1.8e-05	-7.4	-7.1	1.6e-12	0.68	0.16	0.46	FALSE
15	GTEx	Brain Cerebellum	NUSAP1	0.22	0.23	enet	18	0.22	3.7e-07	-6.6	-7.1	1.7e-12	0.59	0.53	0.43	FALSE
41	GTEx	Esophagus Muscularis	NDUFAF1	0.24	0.23	lasso	5	0.28	2.8e-17	-7.8	7.0	1.8e-12	-0.55	0.35	0.65	FALSE
4	GTEx	Adipose Subcutaneous	OIP5-AS1	0.21	0.23	lasso	5	0.26	3.7e-21	-5.8	-7.0	2.1e-12	0.59	0.46	0.54	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	CHP	0.05	0.04	blup	54	0.03	6.0e-04	-7.4	7.0	2.3e-12	-0.60	0.01	0.90	FALSE
50	GTEx	Nerve Tibial	OIP5-AS1	0.20	0.22	enet	21	0.26	1.3e-18	-7.8	-6.9	3.7e-12	0.60	0.35	0.65	FALSE
10	GTEx	Artery Tibial	OIP5-AS1	0.16	0.23	lasso	4	0.24	3.6e-19	-5.8	-6.9	5.6e-12	0.59	0.72	0.28	FALSE
40	GTEx	Esophagus Mucosa	OIP5-AS1	0.20	0.22	lasso	6	0.20	1.7e-13	-6.6	-6.9	5.8e-12	0.52	0.90	0.10	FALSE
11	GTEx	Brain Caudate basal ganglia	NUSAP1	0.31	0.38	lasso	9	0.40	1.1e-12	-6.6	-6.9	6.1e-12	0.55	0.80	0.20	FALSE
42	GTEx	Esophagus Muscularis	OIP5-AS1	0.24	0.24	enet	19	0.28	4.6e-17	-7.8	-6.8	8.6e-12	0.60	0.46	0.54	FALSE
23	GTEx	Brain Hypothalamus	NDUFAF1	0.24	0.12	lasso	5	0.13	5.9e-04	-6.2	6.8	9.2e-12	-0.54	0.20	0.24	FALSE
30	GTEx	Cells EBV-transformed lymphocytes	OIP5-AS1	0.21	0.12	lasso	7	0.10	3.2e-04	-7.8	-6.8	1.0e-11	0.61	0.23	0.21	FALSE
53	GTEx	Pituitary	NUSAP1	0.16	0.12	lasso	2	0.16	7.4e-05	-6.6	-6.8	1.0e-11	0.56	0.28	0.46	FALSE
16	GTEx	Brain Cerebellum	NDUFAF1	0.24	0.26	lasso	8	0.20	1.1e-06	-6.7	6.8	1.1e-11	-0.57	0.52	0.46	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUSAP1	0.03	0.01	blup	40	0.02	3.4e-03	-7.8	6.8	1.4e-11	-0.59	0.01	0.93	FALSE
57	GTEx	Skin Sun Exposed Lower leg	OIP5-AS1	0.13	0.17	lasso	3	0.23	5.0e-19	-5.8	-6.7	1.6e-11	0.60	0.74	0.26	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	NDUFAF1	0.14	0.17	lasso	5	0.18	9.6e-21	-6.6	-6.7	1.6e-11	0.51	0.28	0.72	FALSE
44	GTEx	Heart Left Ventricle	NDUFAF1	0.49	0.62	lasso	8	0.62	2.0e-41	-6.7	6.7	2.0e-11	-0.54	0.99	0.01	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHP	0.21	0.11	lasso	4	0.12	5.1e-13	-5.3	6.7	2.0e-11	-0.65	0.99	0.01	FALSE
19	GTEx	Brain Frontal Cortex BA9	NUSAP1	0.39	0.42	enet	22	0.42	2.0e-12	-6.6	-6.7	2.1e-11	0.66	0.69	0.31	FALSE
43	GTEx	Heart Atrial Appendage	NDUFAF1	0.36	0.28	enet	24	0.34	9.5e-16	-6.7	6.7	2.2e-11	-0.55	0.92	0.08	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	NDUFAF1	0.35	0.46	enet	14	0.51	3.1e-19	-6.6	6.7	2.4e-11	-0.57	0.98	0.02	FALSE
49	GTEx	Nerve Tibial	NDUFAF1	0.36	0.43	lasso	6	0.43	8.0e-33	-6.6	-6.6	3.5e-11	0.52	0.98	0.02	FALSE
59	GTEx	Thyroid	OIP5	0.06	0.03	lasso	5	0.02	1.1e-02	-7.4	-6.6	3.6e-11	0.55	0.40	0.18	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHP	0.01	0.01	blup	54	0.01	1.4e-02	-6.7	6.4	1.9e-10	-0.70	0.07	0.24	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	NDUFAF1	0.13	0.16	enet	8	0.17	2.2e-17	-6.6	-6.4	2.0e-10	0.49	0.26	0.74	FALSE
27	GTEx	Breast Mammary Tissue	OIP5-AS1	0.20	0.24	lasso	7	0.22	1.8e-11	-5.8	-6.3	2.3e-10	0.56	0.99	0.01	FALSE
25	GTEx	Brain Nucleus accumbens basal ganglia	NDUFAF1	0.12	0.11	lasso	6	0.10	9.7e-04	-6.6	6.3	2.4e-10	-0.52	0.23	0.38	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	NDUFAF1	0.04	0.02	lasso	2	0.03	8.9e-08	-6.7	-6.3	2.7e-10	0.42	0.14	0.82	FALSE
64	NTR	Blood	INO80	0.02	0.02	enet	8	0.03	2.8e-09	-6.7	6.3	3.1e-10	-0.79	1.00	0.00	FALSE
52	GTEx	Pancreas	OIP5-AS1	0.07	0.13	lasso	2	0.10	7.5e-05	-5.8	-6.2	4.5e-10	0.52	0.45	0.30	FALSE
38	GTEx	Esophagus Mucosa	NDUFAF1	0.25	0.18	enet	26	0.24	4.3e-16	-4.4	6.2	4.6e-10	-0.54	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NDUFAF1	0.14	0.07	enet	8	0.10	2.5e-11	-6.7	-6.2	4.7e-10	0.40	0.18	0.82	FALSE
54	GTEx	Prostate	NDUFAF1	0.30	0.12	lasso	2	0.14	2.7e-04	-6.1	-6.2	4.9e-10	0.64	0.26	0.12	FALSE
56	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	-6.5	6.2	5.0e-10	-0.80	0.17	0.67	FALSE
31	GTEx	Cells Transformed fibroblasts	NDUFAF1	0.26	0.15	lasso	8	0.20	2.8e-15	-6.1	6.2	6.8e-10	-0.51	0.89	0.11	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NDUFAF1	0.14	0.16	bslmm	304	0.19	6.6e-23	-5.2	6.1	9.5e-10	-0.44	0.91	0.09	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	INO80	0.03	0.02	blup	39	0.03	1.0e-03	-2.8	-6.1	9.9e-10	0.75	0.17	0.56	FALSE
34	GTEx	Colon Sigmoid	NDUFAF1	0.15	0.06	lasso	4	0.06	5.2e-03	-4.4	6.1	1.3e-09	-0.57	0.21	0.48	FALSE
60	GTEx	Thyroid	NDUFAF1	0.25	0.21	lasso	6	0.22	9.3e-17	-6.4	-6.1	1.3e-09	0.56	0.97	0.03	FALSE
17	GTEx	Brain Cortex	NUSAP1	0.43	0.25	enet	27	0.26	8.7e-08	-6.6	-6.0	2.5e-09	0.54	0.73	0.26	FALSE
65	NTR	Blood	NUSAP1	0.03	0.03	lasso	3	0.04	4.9e-12	-7.3	-6.0	2.6e-09	0.58	0.70	0.30	FALSE
28	GTEx	Breast Mammary Tissue (Female)	OIP5-AS1	0.28	0.31	lasso	3	0.29	3.0e-09	-5.8	-5.9	2.7e-09	0.56	0.96	0.03	FALSE
61	GTEx	Thyroid	OIP5-AS1	0.20	0.19	lasso	8	0.20	4.1e-15	-5.8	-5.9	3.0e-09	0.58	0.99	0.01	FALSE
58	GTEx	Testis	OIP5-AS1	0.14	0.16	lasso	1	0.14	8.6e-07	-5.8	-5.8	8.5e-09	0.49	0.80	0.03	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	RTF1	0.04	0.02	lasso	3	0.02	4.0e-03	4.3	5.7	1.1e-08	-0.64	0.02	0.88	FALSE
62	METSIM	Adipose	NDUFAF1	0.08	0.09	bslmm	296	0.09	2.4e-13	-6.2	5.6	2.3e-08	-0.37	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	OIP5	0.07	0.08	lasso	2	0.05	1.6e-04	-5.4	-5.5	3.1e-08	0.69	0.56	0.36	FALSE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC729082	0.15	0.05	blup	44	0.10	8.6e-05	-7.8	5.3	9.3e-08	-0.39	0.01	0.96	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INO80	0.03	0.02	blup	38	0.03	1.1e-02	-2.2	-5.3	1.1e-07	0.72	0.03	0.45	FALSE
18	GTEx	Brain Cortex	NDUFAF1	0.40	0.37	enet	22	0.36	7.0e-11	-5.0	5.3	1.2e-07	-0.49	0.68	0.32	FALSE
32	GTEx	Cells Transformed fibroblasts	CHP1	0.13	0.11	lasso	6	0.11	2.1e-08	-5.2	5.2	2.3e-07	-0.68	0.97	0.03	FALSE
66	YFS	Blood	MGA	0.01	0.00	blup	454	0.00	7.1e-02	-5.8	-5.1	2.7e-07	0.51	0.11	0.15	FALSE
22	GTEx	Brain Hypothalamus	NUSAP1	0.26	0.36	lasso	4	0.27	5.6e-07	-4.0	-5.1	2.8e-07	0.45	0.70	0.16	FALSE