TWAS hub - MGA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.3120	0.1120	0.0051	0.007	NA	0.024	NA	-0.004	0.20	NA	0.07	NA	0.43
2	YFS	Blood	0.0099	0.0053	0.0180	0.002	0.002	0.000	0.002	0.000	0.08	0.071	0.27	0.075	0.24

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Allergy or Eczema	9.4	24.9	47.2	1.6	6.9
Diastolic blood pressure, automated reading	9.1	28.2	53.4	-1.7	7.3
Cardiovascular Disease	8.1	26.7	50.9	-1.6	7.1
Allergy	7.7	17.6	33.1	-1.5	-5.7
Systolic blood pressure, automated reading	7.4	21.4	32.7	-3.2	5.7
Hayfever, allergic rhinitis or eczema	7.3	15.8	29.7	1.4	5.5
Number of treatments/medications taken	7.2	13.0	23.9	1.4	4.9
Medication: Cholesterol lowering	6.8	10.6	21.0	0.4	4.6
Illnesses of father: Heart disease	6.8	9.5	12.7	2.5	3.6
Respiratory disease	6.6	14.7	25.3	2.0	5.0
Medication for cholesterol, blood pressure or diabetes	6.6	11.0	21.8	0.4	-4.7
Hypertension (Self-reported)	6.6	18.4	36.5	-0.6	6.0
High blood pressure	6.5	18.1	36.0	-0.3	6.0
Systolic Blood Pressure	6.4	32.1	58.5	-2.4	7.7
Vascular/heart problems diagnosed by doctor	6.1	16.7	32.3	1.1	-5.7
Hayfever/allergic rhinitis (self-reported)	6.0	8.0	12.6	1.9	3.5
Number of self-reported non-cancer illnesses	5.5	9.6	16.7	1.6	4.1
Asthma (self-reported)	5.3	10.5	18.2	1.6	4.3
Taking other prescription medications	5.1	7.8	13.4	1.5	3.7
Asthma	5.0	9.9	17.8	1.5	4.2
Alcohol drinker status: Never	4.9	5.9	11.8	0.1	3.4
Ever used hormone-replacement therapy (HRT)	4.7	6.0	10.6	1.2	3.3
Had menopause	4.7	5.8	11.6	0.0	3.4
Number of live births	4.7	6.6	11.5	1.3	3.4
Medication: Atorvastatin	4.5	5.6	10.6	0.8	3.3
Medication: Levothyroxine sodium	4.4	7.4	9.8	2.2	3.1
Father’s age at death	4.4	5.8	11.5	-0.5	-3.4
Neuroticism (2016)	4.2	6.0	10.7	1.2	3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	9.6	0.1	3.1
Medication: Blood pressure	4.1	7.8	15.5	0.2	3.9
Triglycerides	4.0	6.5	13.0	-0.0	3.6
Illnesses of siblings	4.0	5.6	9.8	1.2	-3.1
Alcohol intake frequency.	4.0	9.3	15.3	1.8	3.9
Medication: Gliclazide	3.9	4.4	5.1	-1.9	2.3
High cholesterol (Self-reported)	3.9	6.9	12.4	1.1	3.5
Commuting to job workplace: Cycle	3.9	4.7	8.8	0.7	-3.0
Fed-up feelings	3.8	6.8	6.9	2.6	2.6
Medication: Amlodipine	3.8	5.3	9.4	1.1	3.1
High blood pressure (siblings)	3.8	5.5	10.4	-0.8	3.2
Heart disease (siblings)	3.8	4.7	9.2	0.3	3.0
Lung FEV1/FVC ratio	3.6	18.5	27.0	-5.2	3.1
Medication: Ramipril	3.6	4.6	9.0	0.4	3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	5.6	2.4	2.3
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	7.4	1.2	2.7
Medication: Simvastatin	3.5	5.2	8.5	1.4	2.9
Medication: Lansoprazole	3.5	4.0	5.2	1.7	2.3
Arm predicted mass (right)	3.5	18.1	30.3	-2.4	-5.5
Long-standing illness, disability or infirmity	3.5	5.4	9.6	1.1	3.1
Ulcerative Colitis	3.4	5.0	9.5	0.7	-3.1
Trunk fat-free mass	3.3	19.0	33.9	-2.0	-5.8
Trunk predicted mass	3.3	18.6	32.8	-2.1	-5.7
Arm fat-free mass (right)	3.3	16.9	28.1	-2.4	-5.3
Medication: Bendroflumethiazide	3.2	4.9	5.6	-2.4	2.0
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	3.6	1.9	1.7
Medication: Ventolin 100micrograms inhaler	3.0	3.8	6.6	-1.0	2.6
Medication: Seretide 50 evohaler	3.0	3.5	6.5	0.7	2.5
Whole body fat-free mass	3.0	17.0	30.6	-1.8	-5.5
Whole body water mass	2.9	16.6	29.9	-1.8	-5.5
Pulse wave reflection index	2.8	3.4	6.9	0.2	2.6
Mouth/teeth dental problems: Loose teeth	2.8	3.4	6.7	-0.1	-2.6
Impedance of arm (left)	2.7	12.5	21.3	1.9	4.6
Exposure to tobacco smoke at home	2.7	3.0	5.7	0.5	2.4
Diabetes diagnosed by doctor	2.7	4.4	8.1	0.8	2.8
Illnesses of father: None of the above (group 1)	2.7	3.4	5.9	-0.9	-2.4
Average weekly champagne plus white wine intake	2.7	3.8	6.9	-0.8	-2.6
Impedance of arm (right)	2.6	12.3	22.1	1.6	4.7
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	8.0	1.4	2.8
Medication for pain relief, constipation, heartburn	2.5	4.2	7.8	-0.7	-2.8
Impedance of leg (right)	2.4	11.6	22.9	0.4	4.8
Medication: Omeprazole	2.4	2.8	4.6	1.0	2.2
Arm fat-free mass (left)	2.4	12.4	20.4	-2.1	-4.5
Ulcerative Colitis (UC)	2.3	4.4	6.9	1.4	-2.6
Diabetes (father)	2.3	2.8	3.5	-1.5	1.9
Financial difficulties in last 2 years	2.3	3.1	5.5	0.8	2.4
Happiness	2.3	2.8	2.9	1.7	-1.7
Medication: Blood pressure	2.3	4.1	8.2	0.0	2.9
Leg fat-free mass (right)	2.3	12.2	22.9	-1.2	-4.8
Medication for cholesterol	2.3	3.5	6.4	-0.7	-2.5
Leg predicted mass (right)	2.3	12.3	23.1	-1.2	-4.8
Tinnitus: Yes, now most or all of the time	2.3	2.7	3.1	1.5	1.8
Impedance of whole body	2.3	11.8	22.2	1.2	4.7
Arm predicted mass (left)	2.3	11.8	19.5	-2.0	-4.4
Depressed Affect (Nagel 2018)	2.2	4.6	5.3	2.3	2.0
High blood pressure (mother)	2.2	3.1	5.9	0.5	2.4
Pain type(s) experienced in last month: Hip pain	2.2	2.7	3.3	1.5	1.8
Basal metabolic rate	2.2	12.3	21.5	-1.8	-4.6
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	2.6	1.5	1.6
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	4.8	-0.5	-2.2
Shortness of breath walking on level ground	2.1	2.5	4.9	-0.3	2.2
Chest pain or discomfort	2.1	3.0	3.6	1.6	1.9
Bipolar Disorder (2018)	2.0	3.1	6.1	-0.4	-2.5
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.2	1.1	1.8
Illnesses of mother	2.0	2.5	4.7	0.6	-2.2
Leg fat percentage (right)	2.0	7.3	12.3	-1.5	3.5
Commuting to job workplace: Walk	2.0	2.1	3.2	1.0	-1.8
Ovarian Cancer	1.9	2.5	4.9	-0.2	2.2
Sitting height	1.9	13.8	25.8	-1.4	-5.1
Blood Eosinophil Count	1.8	13.8	26.2	-1.2	5.1
Hypothyroidism (self reported)	1.8	4.1	8.2	0.3	2.9
Medication for hormone replacement therapy	1.8	2.0	3.3	1.8	0.8
Medication: Metformin	1.8	2.6	5.1	-0.1	2.3
Chronic bronchitis/emphysema (father)	1.8	2.1	3.9	2.0	-0.6
Impedance of leg (left)	1.8	8.6	17.1	0.5	4.1
Pain all over the body in last month	1.8	1.9	3.7	-0.2	1.9
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.9	0.7	2.0
Chronic bronchitis/emphysema (mother)	1.8	2.1	3.7	-0.6	1.9
Number of full sisters	1.8	2.2	2.7	1.3	1.6
Alzheimer’s Disease (including proxy)	1.7	2.5	3.1	-1.4	-1.8
Crohns Disease (2012)	1.7	2.8	5.1	-0.7	-2.2
HDL Cholesterol	1.7	2.8	4.8	0.9	-2.2
Leg fat-free mass (left)	1.7	9.0	16.2	-1.3	-4.0
Leg predicted mass (left)	1.7	9.1	16.4	-1.3	-4.0
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	3.0	1.7	1.6
Hair/balding pattern: Pattern 2	1.7	2.2	3.7	1.9	-0.8
Leg pain on walking	1.7	2.1	3.6	-0.8	1.9
Leg fat percentage (left)	1.7	6.2	10.4	-1.4	3.2
Neuroticism score	1.6	3.3	5.8	2.4	0.8
Body fat percentage	1.6	6.3	10.8	-1.4	3.3
Alzheimer’s Disease (in father)	1.5	1.6	2.7	-0.7	-1.7
Lupus	1.5	2.3	4.5	0.4	2.1
Ever had hysterectomy (womb removed)	1.5	1.7	3.1	0.5	1.8
Tense / ‘highly strung’	1.5	2.4	2.8	1.4	1.7
Health satisfaction	1.5	1.9	2.9	1.0	1.7
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	1.9	-1.3	-1.4
Medication: Aspirin	1.5	1.9	3.4	0.7	1.8
Trunk fat percentage	1.4	5.8	10.3	-1.1	3.2
Arm fat percentage (right)	1.4	5.5	10.5	-0.7	3.2
Standing height	1.4	14.1	26.4	-1.3	-5.1
Blood clot in the leg (DVT)	1.4	1.8	2.2	-1.1	1.5
Gout (self-reported)	1.4	2.0	3.9	-0.2	-2.0
Birth weight	1.4	3.1	4.6	-1.3	-2.1
Number of full brothers	1.4	1.7	3.4	0.3	1.9
Medication: Aspirin	1.4	1.8	3.4	0.5	1.8
Irritable Bowel Disease (IBD)	1.3	3.1	4.3	1.4	-2.1
Fasting Glucose	1.3	1.5	1.9	-1.4	1.1
Headache pain in last month	1.3	2.2	2.8	1.2	1.7
Mean time to correctly identify matches	1.3	2.4	3.6	1.9	1.1
Illnesses of father: High blood pressure	1.3	1.6	3.0	-0.3	1.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	1.8	-1.3	1.3
Neuroticism (Nagel 2018)	1.2	2.8	3.2	1.6	1.8
Height	1.2	22.8	41.1	-2.1	-6.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.0	-0.6	2.0
Time employed in main current job	1.2	1.4	2.6	-0.5	-1.6
Hair/balding pattern: Pattern 3	1.2	1.8	3.6	-1.9	0.2
Comparative body size at age 10	1.2	3.3	5.1	-1.2	2.3
Emphysema/chronic bronchitis	1.2	1.3	2.6	-1.6	-0.3
Suffer from ‘nerves’	1.2	1.8	3.6	1.9	0.2
Knee pain experienced in last month	1.2	1.8	2.8	1.7	0.9
Arm fat percentage (left)	1.2	4.8	8.9	-0.8	3.0
Friendships satisfaction	1.2	1.5	3.0	1.7	0.1
Ever smoked	1.2	2.1	4.2	0.1	-2.0
Number of operations (self-reported)	1.2	1.8	3.3	0.5	1.8
Pack years of smoking	1.2	1.8	3.1	-0.7	1.8
Mean Putamen Volume	1.1	1.2	1.4	1.2	1.0
Angina	1.1	1.5	2.9	0.3	1.7
Pack years adult smoking proportion	1.1	1.7	2.7	-0.9	1.6
Diabetes (self-reported)	1.1	1.7	2.8	0.7	1.7
Wheeze or whistling in the chest in last year	1.1	1.9	3.5	0.6	1.9
Age at first live birth	1.1	2.0	2.8	-1.1	-1.7
Heart disease (mother)	1.1	1.3	2.1	0.7	1.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.8	1.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	3.2	-1.2	1.8
Reaction Time	1.0	1.8	2.3	1.5	1.2
Lung cancer (father)	1.0	1.2	1.6	-0.9	-1.3
Birth weight of first child	1.0	1.8	3.6	-0.2	-1.9
Loneliness, isolation	1.0	1.4	2.8	1.7	-0.4
Prostate Cancer	0.9	1.3	2.5	0.2	1.6
Diabetes (mother)	0.9	1.1	2.0	-0.4	1.4
Alcohol intake versus 10 years previously	0.9	1.4	1.8	1.4	1.0
Qualifications: A levels/AS levels or equivalent	0.9	2.1	4.0	2.0	-0.4
Mouth/teeth dental problems: Dentures	0.9	1.5	2.1	1.0	1.4
Pulse wave Arterial Stiffness index	0.9	1.0	1.8	-1.4	0.5
Angina (self-reported)	0.9	1.2	2.3	0.4	1.5
Pulse rate, automated reading	0.9	3.0	5.4	2.3	-0.7
Age at last live birth	0.9	1.3	2.4	-0.5	-1.6
Ever taken oral contraceptive pill	0.9	1.0	1.2	-1.1	-0.9
Medication: Lisinopril	0.9	1.2	1.7	-0.8	1.3
Cholesterol lowering medication	0.9	1.4	1.8	1.0	1.4
Alzheimer’s Disease (in mother)	0.8	0.9	1.6	-0.5	-1.3
Major Depression (MDD)	0.8	1.0	1.4	1.2	0.7
Chronotype (morning person)	0.8	1.9	2.4	-1.2	-1.5
Average weekly spirits intake	0.8	1.0	1.6	-0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	0.5	1.4
Hand grip strength (right)	0.8	2.2	2.7	-1.3	-1.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	0.9	0.9	0.9
Had other major operations	0.8	1.0	1.3	1.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.1	-1.2	-1.4
Had major operations	0.8	0.9	1.5	-1.2	0.6
Family relationship satisfaction	0.8	0.9	1.9	1.4	-0.1
Guilty feelings	0.8	1.2	1.4	1.2	1.0
Wears glasses or contact lenses	0.8	0.9	1.7	-1.3	0.0
Hearing aid user	0.8	0.9	1.6	0.5	1.3
Basal cell carcinoma (self-reported)	0.8	1.0	1.3	-0.8	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.7	3.1	-0.6	-1.7
Age at First Birth	0.7	1.0	1.4	0.8	1.2
Primary Biliary Cirrhosis	0.7	1.0	1.6	0.6	1.3
Sensitivity / hurt feelings	0.7	1.1	2.1	0.4	1.4
Supplements: Zinc	0.7	0.8	0.9	0.9	0.8
Prospective memory result	0.7	0.8	1.5	-0.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.0	-2.0	0.5
Peak expiratory flow (PEF)	0.7	1.7	3.0	-1.7	-0.5
Medication: Paracetamol	0.7	1.2	2.2	0.3	1.5
Worry too long after embarrassment	0.7	1.2	2.3	1.5	0.3
Pulse wave peak to peak time	0.7	0.9	0.9	0.9	-1.0
Neck or shoulder pain in last month	0.7	1.0	1.8	0.5	1.3
Leg fat mass (right)	0.7	2.6	2.8	-1.7	1.6
Average weekly red wine intake	0.7	1.1	2.1	1.4	-0.1
Qualifications: nursing, teaching	0.7	1.1	1.8	-0.6	-1.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.2	1.1	0.8
Medication: Paracetamol	0.7	1.1	2.1	-0.3	1.4
Pain experienced in last month	0.7	1.1	2.2	-0.1	-1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-0.1	1.2
BMI	0.6	3.4	6.6	-2.6	0.5
Neuroticism	0.6	1.5	2.1	1.5	0.9
Supplements: Glucosamine	0.6	0.7	1.5	0.0	-1.2
Medication: Atenolol	0.6	0.7	1.2	-0.5	1.1
Number of incorrect matches in round	0.6	1.0	1.9	-1.4	-0.3
Overall health rating	0.6	1.2	2.4	-0.2	1.6
Miserableness	0.6	1.1	1.6	1.2	0.8
Commuting to job workplace: Public transport	0.6	0.7	0.8	0.7	0.9
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	0.2	1.2
Supplements: Calcium	0.6	0.7	1.3	1.2	-0.2
Leg fat mass (left)	0.6	2.2	2.4	-1.6	1.4
HbA1C	0.5	0.5	0.6	0.6	0.8
Medication: Co-codamol	0.5	0.5	0.9	0.3	1.0
Severe depression (siblings)	0.5	0.5	0.8	-0.4	-0.9
Trunk fat mass	0.5	2.0	2.2	-1.5	1.4
Past tobacco smoking	0.5	0.9	1.3	-0.7	1.1
Hearing difficulty/problems with background noise	0.5	0.8	0.9	0.9	-0.8
Weight	0.5	2.7	3.0	-1.7	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.5	-1.9	0.3
Hair/balding pattern: Pattern 4	0.5	1.2	2.3	0.1	-1.5
Medication: Allopurinol	0.5	0.6	1.2	0.3	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.7	0.8	0.7
Whole body fat mass	0.5	2.2	2.3	-1.5	1.4
Mother’s age at death	0.5	0.6	0.9	0.5	-0.9
Average weekly beer plus cider intake	0.5	0.7	0.9	-0.7	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	1.1	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.6	-0.8	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.7	-0.4	0.9
Blood Red Count	0.4	3.4	6.0	-1.0	-2.4
Relative age of first facial hair	0.4	0.9	1.7	-1.3	0.0
Qualifications: None of the above	0.4	0.9	1.8	-1.3	0.1
Falls in the last year	0.4	0.6	1.1	-0.3	1.0
Depression (self-reported)	0.4	0.5	0.8	0.9	0.4
Arm fat mass (right)	0.4	1.8	2.1	-1.2	1.5
Length of working week for main job	0.4	0.4	0.5	-0.6	-0.7
Number of children fathered	0.4	0.5	0.9	-0.2	-0.9
Smoking status: Previous	0.4	0.6	0.9	0.9	-0.6
Financial situation satisfaction	0.4	0.5	0.7	0.5	0.8
Irritability	0.4	0.7	1.3	1.2	0.2
Alcohol drinker status: Previous	0.4	0.5	0.8	0.9	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	-0.8	0.3
Crohns Disease (2017)	0.3	0.7	1.3	1.1	0.2
Breast Cancer	0.3	0.8	1.6	-0.1	-1.3
Blood Platelet Count	0.3	3.0	3.2	1.6	1.8
Lung FVC	0.3	1.3	2.1	-0.7	1.5
Hand grip strength (left)	0.3	0.7	0.8	-0.9	-0.8
Hearing difficulty/problems: Yes	0.3	0.4	0.9	-0.2	-0.9
Townsend deprivation index at recruitment	0.3	0.4	0.6	-0.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.4	0.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.4	0.6	-0.6
Serious illness, injury or assault to yourself	0.3	0.3	0.7	0.1	0.8
Body mass index (BMI)	0.3	1.1	1.3	-1.2	1.0
Waist circumference	0.3	1.1	2.1	-1.5	0.3
Nervous feelings	0.3	0.6	1.1	1.1	-0.1
Mouth/teeth dental problems	0.3	0.5	1.0	-1.0	0.2
Fluid intelligence score	0.3	0.6	1.3	0.1	-1.1
Worrier / anxious feelings	0.3	0.6	0.8	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.7	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.7	-0.1	-0.8
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.1	-0.8
Medication: Ibuprofen	0.3	0.4	0.6	0.8	0.3
Comparative height size at age 10	0.3	1.6	2.8	-0.6	-1.7
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.1	0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.7	-0.3
Mood swings	0.3	0.6	0.9	0.5	0.9
Ever had bowel cancer screening	0.3	0.3	0.4	-0.6	-0.6
Osteoporosis (self-reported)	0.3	0.4	0.5	-0.7	0.6
Arm fat mass (left)	0.3	1.3	1.4	-1.1	1.2
Myopia	0.3	0.5	0.6	0.8	0.5
Worry (Nagel 2018)	0.2	0.3	0.4	0.6	0.5
Schizophrenia (2014)	0.2	0.5	0.8	-0.9	-0.4
Blood White Count	0.2	1.3	2.3	0.5	-1.5
Waist Hip Ratio (WHR)	0.2	1.0	1.4	-1.2	0.8
Hair Pigment	0.2	4.5	9.1	0.1	-3.0
Vitamin and mineral supplements	0.2	0.3	0.4	0.7	0.4
Age when periods started (menarche)	0.2	0.5	0.5	-0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.6	-0.8	-0.6
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.3	0.6
Forced vital capacity (FVC)	0.2	0.9	1.0	-0.9	-1.0
Heart attack	0.2	0.2	0.4	0.2	0.6
Hip circumference	0.2	0.7	1.2	-1.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	-0.1	0.9
Breastfed as a baby	0.2	0.3	0.6	-0.1	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.2	-1.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.6	-0.3
Qualifications: College or University degree	0.2	0.8	1.5	1.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	-0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	0.2
Mineral and other dietary supplements	0.2	0.3	0.5	-0.3	-0.7
Breast cancer (self-reported)	0.2	0.2	0.2	0.4	0.5
Age started oral contraceptive pill	0.2	0.3	0.3	-0.6	0.5
Unable to work because of sickness or disability	0.2	0.2	0.5	0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.0	0.7
Depression (Nagel 2018)	0.1	0.2	0.3	0.2	0.5
Schizophrenia (2018)	0.1	0.2	0.2	-0.5	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.3	-0.5	-0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.5	-0.1
LDL Cholesterol	0.1	0.2	0.2	0.5	-0.4
Heel T-Score	0.1	1.0	2.0	-1.4	0.1
Current tobacco smoking	0.1	0.1	0.3	0.1	0.5
Maternal smoking around birth	0.1	0.1	0.2	0.4	-0.3
Relative age voice broke	0.1	0.1	0.1	0.3	-0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.1	-0.4
Alcohol usually taken with meals	0.1	0.2	0.2	0.5	-0.4
Pulse rate	0.1	0.1	0.2	0.0	-0.5
Noisy workplace	0.1	0.2	0.2	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	-0.3
Loud music exposure frequency	0.1	0.1	0.3	0.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	-0.2	-0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.3	0.2
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.2	-0.7
Back pain experienced in last month	0.1	0.1	0.3	-0.1	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.1	0.2	0.3
Smoking status: Current	0.1	0.2	0.2	-0.5	0.5
Risk taking	0.1	0.1	0.1	0.3	-0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.1	0.4
Ever depressed for a whole week	0.1	0.1	0.2	0.4	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.1	0.2	-0.0
Rheumatoid Arthritis	0.0	0.1	0.1	-0.2	-0.3
Smoking Status	0.0	0.0	0.1	-0.2	-0.0
Tanning	0.0	0.1	0.2	0.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	-0.2
Average weekly fortified wine intake	0.0	0.1	0.1	0.2	0.2
Multivitamins +/- minerals	0.0	0.0	0.1	0.1	-0.2
Glaucoma (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.1	0.2
Migraine (self-reported)	0.0	0.0	0.0	0.1	-0.1
Eye problems/disorders: Cataract	0.0	0.1	0.1	-0.3	-0.0

Hub : Genes

MGA

Models

Trait associations