Hub : Genes

EXD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.040 0.020 0.00053 0.044 0.022 0.037 0.023 0.041 4.5e-06 0.00092 2.1e-05 0.00068 8.1e-06
2 TCGA Testicular Germ Cell Tumors 0.331 0.162 0.00023 0.044 0.097 0.118 NA 0.076 1.2e-02 0.00026 6.1e-05 NA 1.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.8 2.8 3.8 1.9 -1.4
Bipolar Disorder or Schizophrenia 0.7 1.7 1.8 1.3 -1.2
Depressed Affect (Nagel 2018) 2.9 6.1 7.1 -2.3 2.7
Depression (Nagel 2018) 0.4 0.6 0.9 -1.0 0.5
Intelligence (Savage-Jansen 2018) 1.6 5.0 8.7 -1.2 2.9
Neuroticism (Nagel 2018) 1.9 4.4 4.6 -2.1 2.2
Schizophrenia (2018) 0.1 0.1 0.2 0.2 -0.5
Schizophrenia vs Biploar Disorder 0.1 0.1 0.1 0.2 0.4
Worry (Nagel 2018) 1.1 2.2 3.7 -0.9 1.9
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.0 0.0
Alzheimer’s Disease (in father) 3.0 3.2 3.6 1.7 -1.9
Alzheimer’s Disease (including proxy) 1.0 1.5 1.7 1.3 -1.2
Crohns Disease (2017) 0.2 0.4 0.4 -0.7 0.6
Irritable Bowel Disease (IBD) 2.5 6.0 6.4 2.5 -2.4
Ulcerative Colitis (UC) 7.9 14.8 15.3 3.8 -3.9
Major Depression (MDD) 0.8 1.0 1.5 -0.8 1.2
Reaction Time 0.4 0.8 1.1 0.7 -1.1
Verbal and Numeric Reasoning (VNR) 2.0 4.8 8.1 -1.3 2.8
Breast Cancer 0.0 0.1 0.1 0.4 -0.0
Ovarian Cancer 2.9 3.8 5.1 -1.6 2.3
Prostate Cancer 2.4 3.3 6.4 0.6 -2.5
Age at First Birth 1.0 1.5 2.8 -1.7 0.4
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.1 -0.5
Body Mass Index (BMI) (2010) 1.1 1.6 2.2 -1.5 0.9
Coronary Artery Disease (CAD) 0.7 0.8 0.8 -0.9 0.9
Crohns Disease (2012) 0.1 0.2 0.3 0.5 0.4
Mean Putamen Volume 2.6 2.9 5.0 -2.2 0.9
Fasting Glucose 0.2 0.2 0.2 -0.4 -0.5
HbA1C 1.0 1.1 2.1 0.1 -1.5
HDL Cholesterol 1.1 1.9 3.0 1.7 -0.9
LDL Cholesterol 0.2 0.2 0.4 0.6 -0.3
Lupus 1.6 2.5 3.9 -2.0 1.0
Neuroticism (2016) 1.6 2.3 4.2 -2.1 0.6
Primary Biliary Cirrhosis 0.3 0.5 0.8 -0.3 0.9
Rheumatoid Arthritis 0.7 0.9 1.1 0.9 -1.0
Schizophrenia (2014) 0.0 0.1 0.1 0.1 -0.3
Triglycerides 1.0 1.7 2.8 -1.7 0.7
Type 2 Diabetes (T2D) (2012) 2.1 2.4 3.4 1.2 -1.8
Ulcerative Colitis 8.1 11.7 13.1 3.2 -3.6
Blood Eosinophil Count 0.9 7.3 12.7 -3.6 1.4
Blood Platelet Count 0.6 6.9 7.1 -2.6 2.7
Blood Red Count 3.1 30.3 33.5 5.2 -5.8
Blood White Count 2.0 15.0 17.6 4.2 -3.5
Heel T-Score 0.3 2.0 4.0 -2.0 0.3
BMI 1.7 9.9 16.3 -4.0 1.9
Height 6.5 124.7 139.2 10.5 -11.8
Waist Hip Ratio (WHR) 4.1 18.3 23.9 3.6 -4.9
Systolic Blood Pressure 6.5 32.7 51.4 -7.2 3.8
Smoking Status 3.3 7.9 10.9 2.2 -3.3
Allergy or Eczema 17.9 47.2 58.1 -7.6 6.0
Cardiovascular Disease 8.9 29.5 49.6 -7.0 3.1
Hypothyroidism (self reported) 1.1 2.5 3.4 -1.9 1.2
Respiratory disease 5.3 11.7 16.6 -4.1 2.6
Type 2 Diabetes (T2D) (2018) 0.3 0.6 0.9 -0.6 0.9
Lung FEV1/FVC ratio 0.2 1.1 2.1 0.1 -1.5
Lung FVC 6.9 35.2 36.4 -6.0 5.8
Neuroticism 1.4 3.3 4.2 -1.6 2.1
Chronotype (morning person) 0.0 0.1 0.1 0.2 -0.3
Hair Pigment 0.4 11.9 12.0 3.4 -3.5
Tanning 0.1 1.5 2.9 -0.3 1.7
Hand grip strength (left) 2.4 6.2 6.6 2.4 -2.6
Number of treatments/medications taken 5.5 9.8 16.3 -4.0 1.8
Average weekly spirits intake 6.4 7.9 8.5 2.7 -2.9
Sensitivity / hurt feelings 2.6 4.4 5.2 -2.3 1.9
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.1 -0.3 -0.4
Hearing difficulty/problems: Yes 0.3 0.5 0.5 -0.7 0.7
Relative age of first facial hair 0.2 0.5 0.9 -0.3 -0.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.1 0.7 -1.1
Ever used hormone-replacement therapy (HRT) 4.0 5.1 5.4 -2.3 2.2
Ever had hysterectomy (womb removed) 0.7 0.8 0.8 -0.9 0.9
Systolic blood pressure, automated reading 8.0 23.3 33.8 -5.8 3.6
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.6 -0.4
Angina 6.1 7.9 9.8 -2.5 3.1
Medication for hormone replacement therapy 0.8 0.9 1.1 -0.9 1.1
Vitamin and mineral supplements 4.1 5.6 7.6 -1.9 2.8
Supplements: Zinc 0.5 0.6 0.8 0.6 -0.9
Medication: Co-codamol 0.4 0.5 0.6 -0.7 0.6
Medication: Metformin 0.6 0.8 1.1 -1.0 0.8
Diabetes (father) 0.1 0.1 0.1 -0.3 -0.2
Diabetes (mother) 1.0 1.3 1.6 1.0 -1.2
Severe depression (siblings) 1.8 2.0 3.8 0.4 -2.0
Pack years adult smoking proportion 0.2 0.4 0.4 -0.7 0.5
Impedance of leg (right) 0.3 1.3 1.7 -0.9 1.3
Leg fat-free mass (left) 1.5 7.9 11.8 2.0 -3.4
Trunk fat percentage 2.0 8.2 14.1 -3.8 1.5
Hand grip strength (right) 3.8 10.4 12.2 2.9 -3.5
Townsend deprivation index at recruitment 0.7 1.0 1.9 -1.4 0.3
Current tobacco smoking 1.7 2.8 3.2 1.6 -1.8
Average weekly fortified wine intake 0.1 0.2 0.3 0.2 -0.5
Maternal smoking around birth 0.4 0.6 0.8 0.9 -0.7
Fed-up feelings 3.7 6.8 6.9 -2.6 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.4 0.1
Relative age voice broke 1.0 1.5 2.3 0.8 -1.5
Taking other prescription medications 5.5 8.5 12.8 -3.6 2.0
Age when periods started (menarche) 14.5 34.7 42.2 5.2 -6.5
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 3.9 2.0 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 -0.7 -0.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.1 -1.0 0.8
Qualifications: CSEs or equivalent 0.7 0.9 1.3 0.7 -1.2
Serious illness, injury or assault to yourself 1.9 2.3 3.9 0.8 -2.0
High blood pressure 7.9 22.0 34.8 -5.9 3.0
Hayfever, allergic rhinitis or eczema 12.0 26.1 33.9 -5.8 4.3
Multivitamins +/- minerals 6.2 7.8 7.8 2.8 -2.8
Stomach or abdominal pain in last month 1.0 1.3 1.5 -1.0 1.2
Supplements: Glucosamine 1.6 2.1 3.0 1.7 -1.1
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.2 -1.8 -0.2
Medication: Atenolol 2.4 3.0 4.0 -2.0 1.4
Medication: Levothyroxine sodium 2.1 3.5 4.0 -2.0 1.7
Sitting height 3.1 22.3 27.0 5.2 -4.2
Chronic bronchitis/emphysema (father) 0.5 0.6 0.8 0.6 -0.9
High blood pressure (mother) 0.3 0.4 0.7 -0.9 -0.2
Body mass index (BMI) 2.1 8.8 14.2 -3.8 1.9
Impedance of leg (left) 0.1 0.6 1.0 -0.3 1.0
Leg predicted mass (left) 1.5 8.0 12.0 2.0 -3.5
Trunk fat mass 0.6 2.7 5.3 -2.3 0.1
Waist circumference 0.4 1.6 2.7 -0.8 -1.6
Number of incorrect matches in round 0.0 0.1 0.1 0.3 0.2
Past tobacco smoking 4.1 7.5 9.1 -2.4 3.0
Alcohol usually taken with meals 0.3 0.5 0.7 -0.5 0.8
Nervous feelings 0.4 0.7 1.3 0.3 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.1 -0.3 0.3
Hearing difficulty/problems with background noise 3.1 5.0 5.4 -2.1 2.3
Hair/balding pattern: Pattern 2 0.4 0.5 0.6 0.8 -0.6
Had menopause 18.0 22.5 23.7 -4.9 4.6
Had other major operations 4.9 6.0 7.1 -2.7 2.2
Forced vital capacity (FVC) 0.2 0.7 0.7 -0.9 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 -0.6 0.4
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 2.4 1.5 -0.7
Qualifications: None of the above 0.0 0.1 0.1 -0.2 -0.3
Financial difficulties in last 2 years 1.0 1.4 2.5 -0.5 -1.6
Mouth/teeth dental problems 0.3 0.5 0.9 -0.9 0.1
Heart attack 0.8 1.0 1.5 -0.7 1.2
Allergy 11.7 26.9 34.6 5.9 -4.4
Pain all over the body in last month 3.6 3.9 4.0 -2.0 2.0
Diabetes (self-reported) 0.7 1.1 1.4 -0.9 1.2
Hayfever/allergic rhinitis (self-reported) 6.3 8.4 11.7 -3.4 2.3
Medication: Ramipril 4.8 6.2 8.9 -3.0 1.9
Medication: Simvastatin 3.8 5.5 6.7 -2.6 2.1
Fluid intelligence score 0.1 0.2 0.3 0.3 0.6
Illnesses of siblings 3.1 4.3 6.9 2.6 -1.3
Neuroticism score 1.4 3.0 3.4 -1.6 1.8
Weight 0.3 1.3 2.5 -0.3 -1.6
Impedance of arm (right) 0.1 0.5 0.9 -0.9 0.3
Arm fat percentage (right) 3.4 13.5 21.9 -4.7 2.2
Trunk fat-free mass 3.7 21.0 24.6 4.2 -5.0
Hip circumference 0.4 1.5 2.8 -1.7 -0.5
Time employed in main current job 6.9 8.0 8.8 3.0 -2.7
Alcohol intake versus 10 years previously 0.2 0.3 0.4 -0.6 0.5
Father’s age at death 2.8 3.7 7.4 2.7 0.2
Worrier / anxious feelings 2.4 4.5 5.8 -1.8 2.4
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 3.6 -1.9 1.0
Falls in the last year 0.4 0.6 0.7 -0.7 0.8
Hair/balding pattern: Pattern 3 0.4 0.6 1.0 -1.0 0.5
Number of live births 2.9 4.1 4.7 -2.2 1.9
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.2 -1.1 0.8
Pulse rate 0.8 1.3 1.6 1.3 -1.0
Happiness 1.4 1.7 3.1 1.7 -0.6
Noisy workplace 0.6 0.8 1.0 -1.0 0.8
Qualifications: A levels/AS levels or equivalent 1.9 4.2 6.9 -1.2 2.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.0 0.5
Mouth/teeth dental problems: Dentures 0.5 0.9 1.4 0.6 -1.2
Asthma 4.7 9.3 12.1 -3.5 2.6
Medication: Ibuprofen (e.g. Nurofen) 4.2 5.3 8.2 1.5 -2.9
Medication: Cholesterol lowering 7.9 12.3 15.8 -4.0 3.0
Depression (self-reported) 0.2 0.2 0.3 -0.5 -0.4
Medication: Lansoprazole 1.1 1.2 1.7 -1.3 0.9
Prospective memory result 0.1 0.1 0.1 -0.3 -0.3
Lung cancer (father) 1.3 1.5 2.1 1.5 -0.9
Illnesses of mother 2.1 2.6 4.5 2.1 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 3.1 -1.8 1.2
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 -1.1 0.3
Impedance of arm (left) 0.2 0.9 1.3 -1.1 0.7
Arm fat mass (right) 1.4 5.7 10.8 -3.3 0.9
Trunk predicted mass 3.6 20.4 23.7 4.1 -4.9
Standing height 5.5 54.2 56.6 7.2 -7.5
Length of working week for main job 0.5 0.6 0.6 0.8 -0.7
Exposure to tobacco smoke at home 3.4 3.8 6.2 -2.5 1.2
Breastfed as a baby 0.6 0.7 1.1 1.0 -0.7
Tense / ‘highly strung’ 0.8 1.3 1.7 -1.3 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 1.3 -1.2 1.1
Hair/balding pattern: Pattern 4 0.3 0.8 0.9 0.9 -0.9
Birth weight of first child 7.8 14.1 16.6 4.1 -3.4
Peak expiratory flow (PEF) 0.1 0.3 0.3 0.5 -0.6
Pulse wave reflection index 2.4 2.9 5.1 -2.3 0.9
Ever highly irritable/argumentative for 2 days 1.8 2.1 2.8 -1.7 1.2
Loud music exposure frequency 0.2 0.3 0.5 0.2 0.7
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 4.7 -1.3 2.2
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 3.2 -0.5 1.8
Blood clot in the leg (DVT) 2.7 3.5 4.8 -2.2 1.4
Medication: Paracetamol 0.7 1.2 2.1 0.5 -1.5
Headache pain in last month 2.0 3.4 5.0 -2.2 1.3
Medication for cholesterol, blood pressure or diabetes 5.9 9.8 15.8 4.0 -1.9
Glaucoma (self-reported) 1.0 1.1 2.0 -1.4 0.6
Gout (self-reported) 1.6 2.2 2.6 1.6 -1.4
Hypothyroidism/myxoedema (self-reported) 1.7 3.4 3.7 -1.8 1.9
Medication: Amlodipine 2.6 3.7 5.8 -2.4 1.3
Medication: Ventolin 100micrograms inhaler 3.4 4.4 8.1 -2.8 0.8
Birth weight 1.8 3.9 7.2 0.8 -2.7
Chronic bronchitis/emphysema (mother) 2.3 2.7 4.0 -2.0 1.2
High blood pressure (siblings) 4.3 6.1 9.3 -3.0 1.7
Forced vital capacity (FVC), Best measure 0.8 3.1 3.8 -1.9 1.6
Body fat percentage 2.9 11.6 18.6 -4.3 2.1
Leg fat percentage (right) 4.2 15.2 22.3 -4.7 2.8
Arm fat-free mass (right) 2.3 11.9 13.8 3.1 -3.7
Exposure to tobacco smoke outside home 0.1 0.1 0.1 0.3 -0.3
Comparative body size at age 10 3.0 8.2 13.2 -3.6 1.8
Number of full brothers 0.2 0.2 0.3 0.4 -0.5
Worry too long after embarrassment 1.6 2.7 3.6 -1.9 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.3 -0.6
Wheeze or whistling in the chest in last year 0.3 0.5 0.8 -0.9 -0.3
Number of children fathered 2.5 2.8 4.3 2.1 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 -0.0 -0.1
Age at first live birth 0.4 0.6 1.2 0.3 -1.1
Pulse wave peak to peak time 1.3 1.6 2.5 1.6 -0.8
Health satisfaction 1.6 2.0 2.4 -1.6 1.3
Shortness of breath walking on level ground 3.1 3.7 6.2 -2.5 1.1
Qualifications: College or University degree 0.3 1.1 2.1 -0.2 1.4
Eye problems/disorders: None of the above 0.4 0.4 0.5 0.7 -0.6
Mouth/teeth dental problems: Loose teeth 3.2 3.9 6.4 2.5 -1.2
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.2 -0.1
Medication for pain relief, constipation, heartburn 0.5 0.9 1.5 1.2 -0.5
Neck or shoulder pain in last month 1.5 2.1 3.0 -1.7 1.1
Medication: Blood pressure 2.2 3.9 6.0 -2.5 1.3
Angina (self-reported) 6.2 8.1 10.1 -2.5 3.2
Migraine (self-reported) 0.4 0.4 0.6 0.5 0.8
Medication: Ibuprofen 3.8 4.6 7.5 1.3 -2.7
Medication: Allopurinol 0.4 0.5 0.6 0.8 -0.6
Medication: Omeprazole 5.1 6.1 6.5 -2.4 2.5
Medication: Seretide 50 evohaler 3.7 4.2 4.6 -2.1 2.0
Mean time to correctly identify matches 0.0 0.0 0.1 0.2 -0.1
Heart disease (mother) 2.6 3.2 3.9 -2.0 1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.5 -0.4 -0.7
Whole body fat mass 0.9 3.9 7.6 -2.7 0.4
Leg fat mass (right) 1.5 5.8 10.5 -3.2 1.0
Arm predicted mass (right) 2.7 13.8 16.2 3.4 -4.0
Pulse rate, automated reading 0.8 2.6 3.7 1.9 -1.2
Alcohol intake frequency. 2.6 6.0 7.1 -2.7 2.2
Comparative height size at age 10 1.9 10.6 11.9 3.0 -3.5
Number of full sisters 0.4 0.5 0.7 0.6 -0.9
Suffer from ‘nerves’ 2.0 3.1 5.5 -0.8 2.4
Overall health rating 1.5 3.1 5.5 -2.4 0.9
Chest pain or discomfort 3.0 4.4 5.5 -2.4 1.8
Had major operations 1.2 1.4 2.0 -1.4 0.9
Age at last live birth 1.1 1.6 1.9 1.2 -1.4
Family relationship satisfaction 0.0 0.0 0.1 0.3 -0.1
Leg pain on walking 2.0 2.5 2.9 -1.7 1.4
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 4.6 2.1 -1.8
Commuting to job workplace: Car/motor vehicle 1.2 1.4 1.8 -1.0 1.3
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.1 -0.3 1.5
Medication: Aspirin 3.7 4.9 6.7 -1.7 2.6
Supplements: Vitamin C 0.0 0.0 0.0 -0.2 -0.2
Knee pain experienced in last month 0.0 0.0 0.1 0.1 -0.3
Hypertension (Self-reported) 8.4 23.4 37.0 -6.1 3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.2 -0.4 -0.5
Illnesses of father: Heart disease 9.6 13.4 16.5 -4.1 3.2
Illnesses of siblings: Diabetes 0.0 0.0 0.1 -0.3 -0.1
Smoking status: Previous 2.7 4.1 4.9 1.8 -2.2
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 3.0 1.7 -1.7
Whole body fat-free mass 3.0 17.0 20.9 3.6 -4.6
Leg fat-free mass (right) 2.0 11.0 14.7 2.7 -3.8
Arm fat percentage (left) 3.4 13.5 21.7 -4.7 2.3
Average weekly red wine intake 1.4 2.0 2.7 1.6 -1.1
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 0.1 0.3
Mood swings 0.2 0.3 0.5 -0.7 -0.3
Loneliness, isolation 0.6 0.8 0.8 -0.9 0.9
Long-standing illness, disability or infirmity 7.7 11.8 15.8 -4.0 2.8
Ever had bowel cancer screening 1.4 1.7 3.0 0.7 -1.7
Diabetes diagnosed by doctor 0.9 1.4 2.0 -1.4 0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.6 2.8 4.1 -2.0 1.2
Friendships satisfaction 1.1 1.3 2.5 -0.3 1.6
Qualifications: nursing, teaching 0.4 0.6 1.0 0.5 -1.0
Commuting to job workplace: Walk 1.8 2.0 3.7 1.9 -0.6
Eye problems/disorders: Cataract 0.5 0.6 0.7 -0.9 0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.8 0.9 0.2
Medication for cholesterol 5.9 8.9 11.2 3.3 -2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 5.0 5.9 8.6 -2.9 1.8
Back pain experienced in last month 0.1 0.2 0.3 -0.3 -0.5
Mineral and other dietary supplements 1.6 2.2 2.6 -1.6 1.3
Breast cancer (self-reported) 1.2 1.4 2.2 -1.5 0.7
Asthma (self-reported) 4.1 8.2 11.4 -3.4 2.2
Osteoporosis (self-reported) 6.6 8.1 10.2 -3.2 2.5
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.2 0.7
Medication: Aspirin 4.3 5.7 8.1 -1.8 2.9
Medication: Gliclazide 0.2 0.3 0.5 -0.7 -0.2
Illnesses of father: None of the above (group 1) 6.0 7.4 10.1 3.2 -2.2
Smoking status: Current 1.3 2.1 2.1 1.4 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.2 10.9 14.0 -3.7 2.8
Whole body water mass 2.9 16.3 20.2 3.5 -4.5
Leg predicted mass (right) 2.1 11.1 14.8 2.7 -3.9
Arm fat mass (left) 1.4 5.6 10.4 -3.2 0.9
Number of self-reported non-cancer illnesses 5.9 10.3 13.4 -3.7 2.7
Average weekly champagne plus white wine intake 1.4 1.9 3.1 1.8 -0.8
Miserableness 0.9 1.6 2.0 -1.4 1.1
Guilty feelings 0.0 0.1 0.1 -0.3 0.1
Wears glasses or contact lenses 0.8 0.9 1.2 -0.8 1.1
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.6 -0.1
Hearing aid user 0.6 0.6 1.2 -1.1 0.3
Mother’s age at death 0.1 0.1 0.1 -0.3 0.2
Financial situation satisfaction 0.5 0.6 1.0 -0.5 1.0
Tinnitus: Yes, now most or all of the time 4.7 5.5 6.0 -2.3 2.4
Commuting to job workplace: Public transport 1.8 2.1 2.7 -1.6 1.2
Eye problems/disorders: Glaucoma 1.7 2.0 3.0 -1.7 1.0
Medication: Blood pressure 8.7 16.5 20.1 -4.5 3.6
Pain type(s) experienced in last month: Hip pain 1.8 2.3 2.8 -1.7 1.3
Supplements: Fish oil (including cod liver oil) 2.1 2.8 3.3 1.8 -1.5
High cholesterol (Self-reported) 5.2 9.3 11.8 -3.4 2.6
Medication: Bendroflumethiazide 2.6 3.9 4.8 -2.2 1.7
Medication: Paracetamol 0.8 1.2 1.9 0.7 -1.4
Medication: Lisinopril 1.4 1.8 2.9 -1.7 0.8
Medication: Atorvastatin 9.5 11.7 13.7 -3.7 3.1
Illnesses of father: High blood pressure 4.1 5.1 7.2 -2.7 1.7
Alcohol drinker status: Never 5.9 7.1 7.2 -2.6 2.7
Ever smoked 6.4 11.2 13.5 3.0 -3.7
Basal metabolic rate 2.0 11.1 15.2 2.6 -3.9
Leg fat percentage (left) 3.7 13.3 19.8 -4.5 2.6
Arm fat-free mass (left) 1.9 9.7 12.3 2.6 -3.5
Number of operations (self-reported) 2.4 3.6 5.6 -2.4 1.2
Average weekly beer plus cider intake 2.6 3.7 4.6 1.7 -2.1
Irritability 0.0 0.0 0.1 0.3 0.0
Risk taking 2.2 3.2 4.5 1.4 -2.1
Ever had prostate specific antigen (PSA) test 4.8 5.5 7.3 1.9 -2.7
Fractured/broken bones in last 5 years 0.2 0.2 0.3 0.5 -0.5
Age started oral contraceptive pill 0.5 0.6 0.9 -1.0 0.5
Diastolic blood pressure, automated reading 8.2 25.5 37.6 -6.1 3.7
Ever depressed for a whole week 0.2 0.3 0.3 0.5 0.5
Unable to work because of sickness or disability 0.2 0.2 0.5 0.0 -0.7
Commuting to job workplace: Cycle 6.2 7.5 9.3 3.1 -2.4
Myopia 0.4 0.5 0.7 0.6 -0.8
Vascular/heart problems diagnosed by doctor 9.6 26.2 39.8 6.3 -3.5
Cholesterol lowering medication 3.9 5.8 6.1 -2.3 2.5
Medication: Omeprazole (e.g. Zanprol) 5.0 6.1 6.8 -2.3 2.6
Pain experienced in last month 1.8 3.0 4.2 2.0 -1.3
Supplements: Calcium 0.0 0.0 0.1 0.3 0.0
Basal cell carcinoma (self-reported) 0.5 0.5 0.7 0.6 -0.8
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.4 -0.8 1.2
Deep venous thrombosis (DVT) (self-reported) 2.7 3.5 5.0 -2.2 1.4
Heart disease (siblings) 2.7 3.4 5.9 -2.4 0.9
Alcohol drinker status: Previous 0.2 0.2 0.4 0.6 0.2
Pack years of smoking 0.4 0.7 0.7 -0.8 0.8
Impedance of whole body 0.1 0.7 1.0 -0.6 1.0
Leg fat mass (left) 1.4 5.4 9.9 -3.2 0.9
Arm predicted mass (left) 1.9 9.5 12.0 2.7 -3.5