TWAS hub - EXD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.040	0.020	0.00053	0.044	0.022	0.037	0.023	0.041	4.5e-06	0.00092	2.1e-05	0.00068	8.1e-06
2	TCGA	Testicular Germ Cell Tumors	0.331	0.162	0.00023	0.044	0.097	0.118	NA	0.076	1.2e-02	0.00026	6.1e-05	NA	1.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Had menopause	18.0	22.5	23.7	-4.9	4.6
Allergy or Eczema	17.9	47.2	58.1	-7.6	6.0
Age when periods started (menarche)	14.5	34.7	42.2	5.2	-6.5
Hayfever, allergic rhinitis or eczema	12.0	26.1	33.9	-5.8	4.3
Allergy	11.7	26.9	34.6	5.9	-4.4
Illnesses of father: Heart disease	9.6	13.4	16.5	-4.1	3.2
Vascular/heart problems diagnosed by doctor	9.6	26.2	39.8	6.3	-3.5
Medication: Atorvastatin	9.5	11.7	13.7	-3.7	3.1
Cardiovascular Disease	8.9	29.5	49.6	-7.0	3.1
Medication: Blood pressure	8.7	16.5	20.1	-4.5	3.6
Hypertension (Self-reported)	8.4	23.4	37.0	-6.1	3.1
Diastolic blood pressure, automated reading	8.2	25.5	37.6	-6.1	3.7
Ulcerative Colitis	8.1	11.7	13.1	3.2	-3.6
Systolic blood pressure, automated reading	8.0	23.3	33.8	-5.8	3.6
Ulcerative Colitis (UC)	7.9	14.8	15.3	3.8	-3.9
High blood pressure	7.9	22.0	34.8	-5.9	3.0
Medication: Cholesterol lowering	7.9	12.3	15.8	-4.0	3.0
Birth weight of first child	7.8	14.1	16.6	4.1	-3.4
Long-standing illness, disability or infirmity	7.7	11.8	15.8	-4.0	2.8
Lung FVC	6.9	35.2	36.4	-6.0	5.8
Time employed in main current job	6.9	8.0	8.8	3.0	-2.7
Osteoporosis (self-reported)	6.6	8.1	10.2	-3.2	2.5
Height	6.5	124.7	139.2	10.5	-11.8
Systolic Blood Pressure	6.5	32.7	51.4	-7.2	3.8
Average weekly spirits intake	6.4	7.9	8.5	2.7	-2.9
Ever smoked	6.4	11.2	13.5	3.0	-3.7
Hayfever/allergic rhinitis (self-reported)	6.3	8.4	11.7	-3.4	2.3
Multivitamins +/- minerals	6.2	7.8	7.8	2.8	-2.8
Angina (self-reported)	6.2	8.1	10.1	-2.5	3.2
Commuting to job workplace: Cycle	6.2	7.5	9.3	3.1	-2.4
Angina	6.1	7.9	9.8	-2.5	3.1
Illnesses of father: None of the above (group 1)	6.0	7.4	10.1	3.2	-2.2
Medication for cholesterol, blood pressure or diabetes	5.9	9.8	15.8	4.0	-1.9
Medication for cholesterol	5.9	8.9	11.2	3.3	-2.6
Number of self-reported non-cancer illnesses	5.9	10.3	13.4	-3.7	2.7
Alcohol drinker status: Never	5.9	7.1	7.2	-2.6	2.7
Number of treatments/medications taken	5.5	9.8	16.3	-4.0	1.8
Taking other prescription medications	5.5	8.5	12.8	-3.6	2.0
Standing height	5.5	54.2	56.6	7.2	-7.5
Respiratory disease	5.3	11.7	16.6	-4.1	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.2	10.9	14.0	-3.7	2.8
High cholesterol (Self-reported)	5.2	9.3	11.8	-3.4	2.6
Medication: Omeprazole	5.1	6.1	6.5	-2.4	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.0	5.9	8.6	-2.9	1.8
Medication: Omeprazole (e.g. Zanprol)	5.0	6.1	6.8	-2.3	2.6
Had other major operations	4.9	6.0	7.1	-2.7	2.2
Medication: Ramipril	4.8	6.2	8.9	-3.0	1.9
Ever had prostate specific antigen (PSA) test	4.8	5.5	7.3	1.9	-2.7
Asthma	4.7	9.3	12.1	-3.5	2.6
Tinnitus: Yes, now most or all of the time	4.7	5.5	6.0	-2.3	2.4
High blood pressure (siblings)	4.3	6.1	9.3	-3.0	1.7
Medication: Aspirin	4.3	5.7	8.1	-1.8	2.9
Medication: Ibuprofen (e.g. Nurofen)	4.2	5.3	8.2	1.5	-2.9
Leg fat percentage (right)	4.2	15.2	22.3	-4.7	2.8
Waist Hip Ratio (WHR)	4.1	18.3	23.9	3.6	-4.9
Vitamin and mineral supplements	4.1	5.6	7.6	-1.9	2.8
Past tobacco smoking	4.1	7.5	9.1	-2.4	3.0
Asthma (self-reported)	4.1	8.2	11.4	-3.4	2.2
Illnesses of father: High blood pressure	4.1	5.1	7.2	-2.7	1.7
Ever used hormone-replacement therapy (HRT)	4.0	5.1	5.4	-2.3	2.2
Cholesterol lowering medication	3.9	5.8	6.1	-2.3	2.5
Hand grip strength (right)	3.8	10.4	12.2	2.9	-3.5
Medication: Simvastatin	3.8	5.5	6.7	-2.6	2.1
Medication: Ibuprofen	3.8	4.6	7.5	1.3	-2.7
Fed-up feelings	3.7	6.8	6.9	-2.6	2.6
Trunk fat-free mass	3.7	21.0	24.6	4.2	-5.0
Medication: Seretide 50 evohaler	3.7	4.2	4.6	-2.1	2.0
Medication: Aspirin	3.7	4.9	6.7	-1.7	2.6
Leg fat percentage (left)	3.7	13.3	19.8	-4.5	2.6
Pain all over the body in last month	3.6	3.9	4.0	-2.0	2.0
Trunk predicted mass	3.6	20.4	23.7	4.1	-4.9
Arm fat percentage (right)	3.4	13.5	21.9	-4.7	2.2
Exposure to tobacco smoke at home	3.4	3.8	6.2	-2.5	1.2
Medication: Ventolin 100micrograms inhaler	3.4	4.4	8.1	-2.8	0.8
Arm fat percentage (left)	3.4	13.5	21.7	-4.7	2.3
Smoking Status	3.3	7.9	10.9	2.2	-3.3
Mouth/teeth dental problems: Loose teeth	3.2	3.9	6.4	2.5	-1.2
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	4.6	2.1	-1.8
Blood Red Count	3.1	30.3	33.5	5.2	-5.8
Sitting height	3.1	22.3	27.0	5.2	-4.2
Hearing difficulty/problems with background noise	3.1	5.0	5.4	-2.1	2.3
Illnesses of siblings	3.1	4.3	6.9	2.6	-1.3
Shortness of breath walking on level ground	3.1	3.7	6.2	-2.5	1.1
Alzheimer’s Disease (in father)	3.0	3.2	3.6	1.7	-1.9
Comparative body size at age 10	3.0	8.2	13.2	-3.6	1.8
Chest pain or discomfort	3.0	4.4	5.5	-2.4	1.8
Whole body fat-free mass	3.0	17.0	20.9	3.6	-4.6
Depressed Affect (Nagel 2018)	2.9	6.1	7.1	-2.3	2.7
Ovarian Cancer	2.9	3.8	5.1	-1.6	2.3
Number of live births	2.9	4.1	4.7	-2.2	1.9
Body fat percentage	2.9	11.6	18.6	-4.3	2.1
Whole body water mass	2.9	16.3	20.2	3.5	-4.5
Father’s age at death	2.8	3.7	7.4	2.7	0.2
Blood clot in the leg (DVT)	2.7	3.5	4.8	-2.2	1.4
Arm predicted mass (right)	2.7	13.8	16.2	3.4	-4.0
Smoking status: Previous	2.7	4.1	4.9	1.8	-2.2
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	5.0	-2.2	1.4
Heart disease (siblings)	2.7	3.4	5.9	-2.4	0.9
Mean Putamen Volume	2.6	2.9	5.0	-2.2	0.9
Sensitivity / hurt feelings	2.6	4.4	5.2	-2.3	1.9
Medication: Amlodipine	2.6	3.7	5.8	-2.4	1.3
Heart disease (mother)	2.6	3.2	3.9	-2.0	1.6
Alcohol intake frequency.	2.6	6.0	7.1	-2.7	2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	4.1	-2.0	1.2
Medication: Bendroflumethiazide	2.6	3.9	4.8	-2.2	1.7
Average weekly beer plus cider intake	2.6	3.7	4.6	1.7	-2.1
Irritable Bowel Disease (IBD)	2.5	6.0	6.4	2.5	-2.4
Number of children fathered	2.5	2.8	4.3	2.1	-1.1
Prostate Cancer	2.4	3.3	6.4	0.6	-2.5
Hand grip strength (left)	2.4	6.2	6.6	2.4	-2.6
Medication: Atenolol	2.4	3.0	4.0	-2.0	1.4
Worrier / anxious feelings	2.4	4.5	5.8	-1.8	2.4
Pulse wave reflection index	2.4	2.9	5.1	-2.3	0.9
Number of operations (self-reported)	2.4	3.6	5.6	-2.4	1.2
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	3.9	2.0	-1.2
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.0	-2.0	1.2
Arm fat-free mass (right)	2.3	11.9	13.8	3.1	-3.7
Medication: Blood pressure	2.2	3.9	6.0	-2.5	1.3
Risk taking	2.2	3.2	4.5	1.4	-2.1
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.4	1.2	-1.8
Medication: Levothyroxine sodium	2.1	3.5	4.0	-2.0	1.7
Body mass index (BMI)	2.1	8.8	14.2	-3.8	1.9
Illnesses of mother	2.1	2.6	4.5	2.1	-0.9
Leg predicted mass (right)	2.1	11.1	14.8	2.7	-3.9
Supplements: Fish oil (including cod liver oil)	2.1	2.8	3.3	1.8	-1.5
Verbal and Numeric Reasoning (VNR)	2.0	4.8	8.1	-1.3	2.8
Blood White Count	2.0	15.0	17.6	4.2	-3.5
Trunk fat percentage	2.0	8.2	14.1	-3.8	1.5
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	4.7	-1.3	2.2
Headache pain in last month	2.0	3.4	5.0	-2.2	1.3
Suffer from ‘nerves’	2.0	3.1	5.5	-0.8	2.4
Leg pain on walking	2.0	2.5	2.9	-1.7	1.4
Leg fat-free mass (right)	2.0	11.0	14.7	2.7	-3.8
Basal metabolic rate	2.0	11.1	15.2	2.6	-3.9
Neuroticism (Nagel 2018)	1.9	4.4	4.6	-2.1	2.2
Serious illness, injury or assault to yourself	1.9	2.3	3.9	0.8	-2.0
Qualifications: A levels/AS levels or equivalent	1.9	4.2	6.9	-1.2	2.6
Comparative height size at age 10	1.9	10.6	11.9	3.0	-3.5
Arm fat-free mass (left)	1.9	9.7	12.3	2.6	-3.5
Arm predicted mass (left)	1.9	9.5	12.0	2.7	-3.5
Bipolar Disorder (2018)	1.8	2.8	3.8	1.9	-1.4
Severe depression (siblings)	1.8	2.0	3.8	0.4	-2.0
Ever highly irritable/argumentative for 2 days	1.8	2.1	2.8	-1.7	1.2
Birth weight	1.8	3.9	7.2	0.8	-2.7
Commuting to job workplace: Walk	1.8	2.0	3.7	1.9	-0.6
Commuting to job workplace: Public transport	1.8	2.1	2.7	-1.6	1.2
Pain type(s) experienced in last month: Hip pain	1.8	2.3	2.8	-1.7	1.3
Pain experienced in last month	1.8	3.0	4.2	2.0	-1.3
BMI	1.7	9.9	16.3	-4.0	1.9
Current tobacco smoking	1.7	2.8	3.2	1.6	-1.8
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	3.7	-1.8	1.9
Eye problems/disorders: Glaucoma	1.7	2.0	3.0	-1.7	1.0
Intelligence (Savage-Jansen 2018)	1.6	5.0	8.7	-1.2	2.9
Lupus	1.6	2.5	3.9	-2.0	1.0
Neuroticism (2016)	1.6	2.3	4.2	-2.1	0.6
Supplements: Glucosamine	1.6	2.1	3.0	1.7	-1.1
Gout (self-reported)	1.6	2.2	2.6	1.6	-1.4
Worry too long after embarrassment	1.6	2.7	3.6	-1.9	1.3
Health satisfaction	1.6	2.0	2.4	-1.6	1.3
Mineral and other dietary supplements	1.6	2.2	2.6	-1.6	1.3
Leg fat-free mass (left)	1.5	7.9	11.8	2.0	-3.4
Leg predicted mass (left)	1.5	8.0	12.0	2.0	-3.5
Neck or shoulder pain in last month	1.5	2.1	3.0	-1.7	1.1
Leg fat mass (right)	1.5	5.8	10.5	-3.2	1.0
Overall health rating	1.5	3.1	5.5	-2.4	0.9
Neuroticism	1.4	3.3	4.2	-1.6	2.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.2	-1.8	-0.2
Neuroticism score	1.4	3.0	3.4	-1.6	1.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	3.6	-1.9	1.0
Happiness	1.4	1.7	3.1	1.7	-0.6
Arm fat mass (right)	1.4	5.7	10.8	-3.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	3.0	1.7	-1.7
Average weekly red wine intake	1.4	2.0	2.7	1.6	-1.1
Ever had bowel cancer screening	1.4	1.7	3.0	0.7	-1.7
Arm fat mass (left)	1.4	5.6	10.4	-3.2	0.9
Average weekly champagne plus white wine intake	1.4	1.9	3.1	1.8	-0.8
Medication: Lisinopril	1.4	1.8	2.9	-1.7	0.8
Leg fat mass (left)	1.4	5.4	9.9	-3.2	0.9
Lung cancer (father)	1.3	1.5	2.1	1.5	-0.9
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.2	-0.5	1.8
Pulse wave peak to peak time	1.3	1.6	2.5	1.6	-0.8
Smoking status: Current	1.3	2.1	2.1	1.4	-1.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.4	1.5	-0.7
Had major operations	1.2	1.4	2.0	-1.4	0.9
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.8	-1.0	1.3
Breast cancer (self-reported)	1.2	1.4	2.2	-1.5	0.7
Worry (Nagel 2018)	1.1	2.2	3.7	-0.9	1.9
Body Mass Index (BMI) (2010)	1.1	1.6	2.2	-1.5	0.9
HDL Cholesterol	1.1	1.9	3.0	1.7	-0.9
Hypothyroidism (self reported)	1.1	2.5	3.4	-1.9	1.2
Medication: Lansoprazole	1.1	1.2	1.7	-1.3	0.9
Age at last live birth	1.1	1.6	1.9	1.2	-1.4
Friendships satisfaction	1.1	1.3	2.5	-0.3	1.6
Alzheimer’s Disease (including proxy)	1.0	1.5	1.7	1.3	-1.2
Age at First Birth	1.0	1.5	2.8	-1.7	0.4
HbA1C	1.0	1.1	2.1	0.1	-1.5
Triglycerides	1.0	1.7	2.8	-1.7	0.7
Diabetes (mother)	1.0	1.3	1.6	1.0	-1.2
Relative age voice broke	1.0	1.5	2.3	0.8	-1.5
Stomach or abdominal pain in last month	1.0	1.3	1.5	-1.0	1.2
Financial difficulties in last 2 years	1.0	1.4	2.5	-0.5	-1.6
Glaucoma (self-reported)	1.0	1.1	2.0	-1.4	0.6
Blood Eosinophil Count	0.9	7.3	12.7	-3.6	1.4
Whole body fat mass	0.9	3.9	7.6	-2.7	0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.1	-0.3	1.5
Diabetes diagnosed by doctor	0.9	1.4	2.0	-1.4	0.9
Miserableness	0.9	1.6	2.0	-1.4	1.1
Major Depression (MDD)	0.8	1.0	1.5	-0.8	1.2
Medication for hormone replacement therapy	0.8	0.9	1.1	-0.9	1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.1	-1.0	0.8
Heart attack	0.8	1.0	1.5	-0.7	1.2
Pulse rate	0.8	1.3	1.6	1.3	-1.0
Tense / ‘highly strung’	0.8	1.3	1.7	-1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.3	-1.2	1.1
Forced vital capacity (FVC), Best measure	0.8	3.1	3.8	-1.9	1.6
Pulse rate, automated reading	0.8	2.6	3.7	1.9	-1.2
Wears glasses or contact lenses	0.8	0.9	1.2	-0.8	1.1
Medication: Paracetamol	0.8	1.2	1.9	0.7	-1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.4	-0.8	1.2
Bipolar Disorder or Schizophrenia	0.7	1.7	1.8	1.3	-1.2
Coronary Artery Disease (CAD)	0.7	0.8	0.8	-0.9	0.9
Rheumatoid Arthritis	0.7	0.9	1.1	0.9	-1.0
Ever had hysterectomy (womb removed)	0.7	0.8	0.8	-0.9	0.9
Townsend deprivation index at recruitment	0.7	1.0	1.9	-1.4	0.3
Qualifications: CSEs or equivalent	0.7	0.9	1.3	0.7	-1.2
Diabetes (self-reported)	0.7	1.1	1.4	-0.9	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.1	-1.8	1.2
Medication: Paracetamol	0.7	1.2	2.1	0.5	-1.5
Blood Platelet Count	0.6	6.9	7.1	-2.6	2.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.1	0.7	-1.1
Medication: Metformin	0.6	0.8	1.1	-1.0	0.8
Trunk fat mass	0.6	2.7	5.3	-2.3	0.1
Noisy workplace	0.6	0.8	1.0	-1.0	0.8
Breastfed as a baby	0.6	0.7	1.1	1.0	-0.7
Loneliness, isolation	0.6	0.8	0.8	-0.9	0.9
Hearing aid user	0.6	0.6	1.2	-1.1	0.3
Supplements: Zinc	0.5	0.6	0.8	0.6	-0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	0.6	-0.9
Mouth/teeth dental problems: Dentures	0.5	0.9	1.4	0.6	-1.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-1.1	0.3
Length of working week for main job	0.5	0.6	0.6	0.8	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	1.2	-0.5
Eye problems/disorders: Cataract	0.5	0.6	0.7	-0.9	0.6
Financial situation satisfaction	0.5	0.6	1.0	-0.5	1.0
Age started oral contraceptive pill	0.5	0.6	0.9	-1.0	0.5
Basal cell carcinoma (self-reported)	0.5	0.5	0.7	0.6	-0.8
Depression (Nagel 2018)	0.4	0.6	0.9	-1.0	0.5
Reaction Time	0.4	0.8	1.1	0.7	-1.1
Hair Pigment	0.4	11.9	12.0	3.4	-3.5
Medication: Co-codamol	0.4	0.5	0.6	-0.7	0.6
Maternal smoking around birth	0.4	0.6	0.8	0.9	-0.7
Waist circumference	0.4	1.6	2.7	-0.8	-1.6
Nervous feelings	0.4	0.7	1.3	0.3	1.1
Hair/balding pattern: Pattern 2	0.4	0.5	0.6	0.8	-0.6
Hip circumference	0.4	1.5	2.8	-1.7	-0.5
Falls in the last year	0.4	0.6	0.7	-0.7	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-1.0	0.5
Age at first live birth	0.4	0.6	1.2	0.3	-1.1
Eye problems/disorders: None of the above	0.4	0.4	0.5	0.7	-0.6
Migraine (self-reported)	0.4	0.4	0.6	0.5	0.8
Medication: Allopurinol	0.4	0.5	0.6	0.8	-0.6
Number of full sisters	0.4	0.5	0.7	0.6	-0.9
Qualifications: nursing, teaching	0.4	0.6	1.0	0.5	-1.0
Myopia	0.4	0.5	0.7	0.6	-0.8
Pack years of smoking	0.4	0.7	0.7	-0.8	0.8
Primary Biliary Cirrhosis	0.3	0.5	0.8	-0.3	0.9
Heel T-Score	0.3	2.0	4.0	-2.0	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.9	-0.6	0.9
Hearing difficulty/problems: Yes	0.3	0.5	0.5	-0.7	0.7
Impedance of leg (right)	0.3	1.3	1.7	-0.9	1.3
High blood pressure (mother)	0.3	0.4	0.7	-0.9	-0.2
Alcohol usually taken with meals	0.3	0.5	0.7	-0.5	0.8
Mouth/teeth dental problems	0.3	0.5	0.9	-0.9	0.1
Weight	0.3	1.3	2.5	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.2	-1.1	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	0.9	0.9	-0.9
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	-0.9	-0.3
Qualifications: College or University degree	0.3	1.1	2.1	-0.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	-0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	0.9	0.2
Crohns Disease (2017)	0.2	0.4	0.4	-0.7	0.6
Fasting Glucose	0.2	0.2	0.2	-0.4	-0.5
LDL Cholesterol	0.2	0.2	0.4	0.6	-0.3
Lung FEV1/FVC ratio	0.2	1.1	2.1	0.1	-1.5
Relative age of first facial hair	0.2	0.5	0.9	-0.3	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.6	-0.4
Pack years adult smoking proportion	0.2	0.4	0.4	-0.7	0.5
Forced vital capacity (FVC)	0.2	0.7	0.7	-0.9	0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.4	-0.6	0.5
Depression (self-reported)	0.2	0.2	0.3	-0.5	-0.4
Impedance of arm (left)	0.2	0.9	1.3	-1.1	0.7
Loud music exposure frequency	0.2	0.3	0.5	0.2	0.7
Number of full brothers	0.2	0.2	0.3	0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.2	-0.4	-0.5
Mood swings	0.2	0.3	0.5	-0.7	-0.3
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.2	0.7
Medication: Gliclazide	0.2	0.3	0.5	-0.7	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.6	-0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.5	-0.5
Ever depressed for a whole week	0.2	0.3	0.3	0.5	0.5
Unable to work because of sickness or disability	0.2	0.2	0.5	0.0	-0.7
Alcohol drinker status: Previous	0.2	0.2	0.4	0.6	0.2
Schizophrenia (2018)	0.1	0.1	0.2	0.2	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	0.2	0.4
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.1	-0.5
Crohns Disease (2012)	0.1	0.2	0.3	0.5	0.4
Tanning	0.1	1.5	2.9	-0.3	1.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.3	-0.4
Diabetes (father)	0.1	0.1	0.1	-0.3	-0.2
Average weekly fortified wine intake	0.1	0.2	0.3	0.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.7	-0.1
Impedance of leg (left)	0.1	0.6	1.0	-0.3	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	-0.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.6	0.4
Fluid intelligence score	0.1	0.2	0.3	0.3	0.6
Impedance of arm (right)	0.1	0.5	0.9	-0.9	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.0	0.5
Prospective memory result	0.1	0.1	0.1	-0.3	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.3	0.5	-0.6
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.3	-0.3
Back pain experienced in last month	0.1	0.2	0.3	-0.3	-0.5
Mother’s age at death	0.1	0.1	0.1	-0.3	0.2
Impedance of whole body	0.1	0.7	1.0	-0.6	1.0
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.0	0.0
Breast Cancer	0.0	0.1	0.1	0.4	-0.0
Schizophrenia (2014)	0.0	0.1	0.1	0.1	-0.3
Chronotype (morning person)	0.0	0.1	0.1	0.2	-0.3
Number of incorrect matches in round	0.0	0.1	0.1	0.3	0.2
Qualifications: None of the above	0.0	0.1	0.1	-0.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.0	-0.1
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	-0.1
Mean time to correctly identify matches	0.0	0.0	0.1	0.2	-0.1
Family relationship satisfaction	0.0	0.0	0.1	0.3	-0.1
Supplements: Vitamin C	0.0	0.0	0.0	-0.2	-0.2
Knee pain experienced in last month	0.0	0.0	0.1	0.1	-0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.1	0.3
Guilty feelings	0.0	0.1	0.1	-0.3	0.1
Irritability	0.0	0.0	0.1	0.3	0.0
Supplements: Calcium	0.0	0.0	0.1	0.3	0.0

Hub : Genes

EXD1

Models

Trait associations