Hub : Genes

INO80

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.0860 0.0360 3.8e-05 0.002 NA 0.026 NA 0.016 2.3e-01 NA 3.1e-03 NA 1.5e-02
2 NTR Blood 0.0207 0.0076 1.9e-06 0.023 0.020 0.027 0.02 0.027 4.3e-08 2.5e-07 2.8e-09 2.6e-07 3.5e-09
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.0340 0.0230 7.6e-03 0.019 0.027 0.006 NA 0.010 2.7e-02 1.1e-02 1.4e-01 NA 7.9e-02
4 TCGA Pancreatic Adenocarcinoma 0.0730 0.0490 2.1e-03 0.036 0.064 0.049 NA 0.028 1.2e-02 1.2e-03 3.9e-03 NA 2.3e-02
5 TCGA Thyroid Carcinoma 0.0300 0.0180 3.6e-04 0.017 0.027 0.009 NA 0.009 8.6e-03 1.0e-03 4.3e-02 NA 3.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.5 2.4 2.7 -1.6 1.6 -1.6 -1.4 -1.6
Bipolar Disorder or Schizophrenia 1.1 2.7 3.8 -1.0 1.6 -1.9 -1.7 -1.8
Depressed Affect (Nagel 2018) 3.1 6.5 7.5 2.3 -2.6 2.5 2.7 2.7
Depression (Nagel 2018) 0.4 0.6 1.3 0.5 -0.7 0.6 1.1 0.9
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.6 0.3 -0.9 1.3 1.1 0.8
Neuroticism (Nagel 2018) 1.6 3.8 4.7 1.6 -2.2 1.7 2.1 2.1
Schizophrenia (2018) 0.4 0.8 1.4 -0.0 0.7 -1.2 -1.0 -1.0
Schizophrenia vs Biploar Disorder 0.4 0.6 1.0 0.6 0.6 -0.4 -1.0 -1.0
Worry (Nagel 2018) 0.3 0.7 1.2 0.1 -1.1 0.6 1.1 0.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 -0.5 0.5 -0.6 -0.1 -0.2
Alzheimer’s Disease (in father) 0.7 0.8 1.3 -0.6 1.1 -0.8 -0.9 -1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 0.9 -0.7 0.9 -0.9 -0.7 -0.7
Crohns Disease (2017) 0.9 2.0 2.6 1.3 -1.4 1.6 1.4 1.4
Irritable Bowel Disease (IBD) 1.7 4.1 5.0 -2.2 2.2 -1.9 -2.0 -1.9
Ulcerative Colitis (UC) 8.1 15.2 18.9 -4.4 3.9 -3.9 -3.8 -3.5
Major Depression (MDD) 0.4 0.4 2.1 1.4 0.2 0.1 0.0 0.1
Reaction Time 0.8 1.5 2.1 0.3 1.5 -1.3 -1.3 -1.4
Verbal and Numeric Reasoning (VNR) 0.7 1.7 2.9 0.2 -1.4 1.7 1.5 1.3
Breast Cancer 0.4 0.9 1.5 0.2 1.2 -0.9 -1.0 -1.1
Ovarian Cancer 3.6 4.8 8.8 3.0 -1.8 2.1 2.0 1.8
Prostate Cancer 0.1 0.1 0.5 -0.7 0.0 -0.3 0.1 0.3
Age at First Birth 0.4 0.5 0.8 -0.2 -0.8 0.9 0.8 0.8
Bipolar Disorder (2011) 0.0 0.0 0.1 -0.3 0.1 -0.4 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.4 0.7 -1.2 0.5 1.2 1.1
Coronary Artery Disease (CAD) 0.5 0.6 0.9 -0.5 -1.0 0.6 0.8 0.8
Crohns Disease (2012) 0.1 0.2 0.4 0.6 -0.3 0.6 0.2 0.3
Mean Putamen Volume 3.2 3.6 4.5 1.5 -2.1 2.0 1.9 2.0
Fasting Glucose 0.2 0.3 0.8 -0.9 0.1 -0.7 -0.2 -0.2
HbA1C 0.4 0.4 1.7 -1.3 0.4 -0.6 0.1 -0.0
HDL Cholesterol 1.6 2.7 3.5 -1.2 1.8 -1.2 -1.9 -1.9
LDL Cholesterol 0.3 0.4 0.8 0.4 0.9 -0.3 -0.9 -0.7
Lupus 1.8 2.8 4.7 0.3 -2.2 1.3 1.8 2.0
Neuroticism (2016) 1.9 2.7 3.7 1.3 -1.9 1.3 1.8 1.8
Primary Biliary Cirrhosis 0.2 0.3 0.5 0.1 -0.7 0.6 0.5 0.4
Rheumatoid Arthritis 2.1 2.9 4.7 -2.2 1.4 -1.7 -1.6 -1.6
Schizophrenia (2014) 0.3 0.7 1.2 -0.3 0.5 -1.1 -1.0 -1.0
Triglycerides 2.5 4.1 5.7 1.6 -2.2 2.0 1.9 2.4
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.4 -1.5 0.9 -1.3 -1.2 -0.8
Ulcerative Colitis 6.1 8.9 10.4 -3.2 3.1 -2.8 -3.0 -2.7
Blood Eosinophil Count 0.3 2.2 3.1 1.2 -1.8 1.2 1.6 1.6
Blood Platelet Count 0.7 8.2 9.4 2.6 -2.9 3.0 3.1 2.8
Blood Red Count 2.0 19.4 29.7 -0.0 5.4 -3.8 -5.5 -4.8
Blood White Count 1.0 7.6 13.0 -1.4 3.6 -2.4 -3.0 -2.9
Heel T-Score 0.6 4.8 8.4 0.4 -2.1 2.1 2.9 2.6
BMI 1.7 10.0 17.7 4.2 -3.0 2.6 3.0 2.8
Height 4.6 88.4 123.2 -7.3 10.1 -8.4 -11.1 -9.6
Waist Hip Ratio (WHR) 1.6 7.4 10.6 -0.8 3.2 -2.8 -3.3 -2.7
Systolic Blood Pressure 8.0 40.0 55.2 2.9 -7.4 5.8 7.2 7.1
Smoking Status 2.6 6.2 7.9 -1.5 2.6 -2.7 -2.8 -2.6
Allergy or Eczema 15.2 40.1 48.7 5.7 -7.0 6.3 6.4 6.2
Cardiovascular Disease 10.2 33.8 43.9 4.2 -6.6 5.7 6.1 6.2
Hypothyroidism (self reported) 1.9 4.4 5.8 2.4 -2.0 1.9 1.9 2.2
Respiratory disease 3.8 8.4 11.6 2.4 -3.4 2.5 3.0 3.0
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.8 0.9 -0.1 -0.5 -0.0 -0.1
Lung FEV1/FVC ratio 0.2 1.2 5.4 2.3 0.3 -0.5 -0.5 -0.3
Lung FVC 6.0 30.6 38.5 4.5 -6.2 5.6 5.7 5.6
Neuroticism 1.0 2.3 3.1 1.2 -1.8 1.2 1.7 1.6
Chronotype (morning person) 0.1 0.2 0.4 0.6 -0.7 0.4 0.3 0.2
Hair Pigment 0.7 20.1 22.9 -4.2 4.0 -4.8 -4.6 -4.8
Tanning 0.0 0.3 0.6 0.8 -0.3 0.7 0.2 0.3
Hand grip strength (left) 1.8 4.7 6.5 -1.7 1.8 -2.2 -2.6 -2.4
Number of treatments/medications taken 5.3 9.5 11.8 3.2 -3.4 2.8 3.0 3.0
Average weekly spirits intake 4.8 5.9 7.6 -1.0 2.6 -2.6 -2.7 -2.8
Sensitivity / hurt feelings 2.5 4.3 5.7 1.7 -2.3 1.6 2.4 2.3
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.5 -0.2 -0.1 0.5 0.5
Hearing difficulty/problems: Yes 0.4 0.5 0.7 -0.8 -0.8 0.7 0.5 0.8
Relative age of first facial hair 0.1 0.2 0.5 -0.4 0.3 -0.2 -0.7 -0.5
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.1 -0.8 0.9 -1.1 -0.9 -0.8
Ever used hormone-replacement therapy (HRT) 5.1 6.5 7.9 2.2 -2.2 2.6 2.8 2.8
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.4 0.2 -0.4 -0.1 -0.2
Systolic blood pressure, automated reading 9.1 26.3 37.3 2.8 -6.1 4.5 5.9 5.5
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.0 0.1 -0.1 -0.0 0.2
Angina 3.9 5.1 7.7 2.8 -2.1 2.4 1.9 2.1
Medication for hormone replacement therapy 0.2 0.2 0.4 -0.3 -0.5 0.2 0.6 0.5
Vitamin and mineral supplements 1.5 2.0 2.5 1.2 -1.5 1.5 1.6 1.3
Supplements: Zinc 0.6 0.6 1.0 0.2 0.9 -0.6 -1.0 -0.9
Medication: Co-codamol 0.5 0.5 1.0 1.0 -1.0 0.6 0.3 0.6
Medication: Metformin 0.3 0.5 1.9 1.4 -0.6 -0.1 0.3 0.3
Diabetes (father) 0.0 0.1 0.2 -0.4 0.2 -0.3 -0.2 -0.1
Diabetes (mother) 0.2 0.3 0.7 0.9 0.5 -0.1 -0.6 -0.2
Severe depression (siblings) 1.7 1.9 2.7 -1.6 0.9 -1.6 -1.4 -1.3
Pack years adult smoking proportion 0.8 1.2 3.6 1.9 -0.8 0.9 0.5 0.7
Impedance of leg (right) 0.4 1.7 2.7 1.0 -1.1 1.6 1.3 1.4
Leg fat-free mass (left) 0.8 4.5 7.9 -0.5 2.2 -2.0 -2.8 -2.3
Trunk fat percentage 1.6 6.6 11.5 3.4 -2.5 2.1 2.4 2.2
Hand grip strength (right) 1.8 4.8 7.3 -1.6 2.1 -2.0 -2.7 -2.3
Townsend deprivation index at recruitment 1.3 1.9 3.5 1.9 -1.2 1.1 1.1 1.4
Current tobacco smoking 1.3 2.2 3.1 -1.2 1.8 -1.6 -1.5 -1.4
Average weekly fortified wine intake 0.2 0.2 0.5 0.0 0.3 -0.7 -0.5 -0.6
Maternal smoking around birth 2.7 3.9 5.2 -2.3 1.8 -2.1 -1.7 -1.9
Fed-up feelings 4.3 7.8 9.1 2.4 -2.9 2.8 2.8 3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 0.3 -0.0 -0.1 0.2 0.2
Relative age voice broke 0.9 1.4 1.8 -1.1 1.2 -1.2 -1.4 -1.1
Taking other prescription medications 5.2 8.0 12.2 2.6 -3.5 2.2 3.0 2.7
Age when periods started (menarche) 8.4 20.2 29.3 -2.2 4.8 -4.3 -5.4 -5.0
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.4 0.8 1.4 -0.7 -1.5 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 2.8 0.8 -1.2 1.5 1.7 1.6
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 3.4 1.2 -1.9 1.5 1.4 1.5
Qualifications: CSEs or equivalent 1.9 2.5 7.6 -2.8 1.0 -1.5 -0.9 -0.9
Serious illness, injury or assault to yourself 1.0 1.2 1.7 -0.4 1.1 -1.3 -1.2 -1.1
High blood pressure 7.1 19.8 28.9 3.2 -5.4 4.0 4.7 4.7
Hayfever, allergic rhinitis or eczema 9.0 19.5 25.3 3.6 -5.0 4.5 4.5 4.4
Multivitamins +/- minerals 5.2 6.6 9.4 -1.1 3.1 -2.5 -3.0 -2.6
Stomach or abdominal pain in last month 0.6 0.8 1.1 0.7 -1.1 0.9 0.7 0.9
Supplements: Glucosamine 2.6 3.4 4.5 -1.1 2.1 -1.8 -1.9 -2.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.0 1.0 -0.9 0.3 0.7 0.8
Medication: Atenolol 1.9 2.4 6.6 2.6 -1.4 1.2 1.1 0.8
Medication: Levothyroxine sodium 2.6 4.4 7.6 2.8 -1.8 2.0 1.8 2.0
Sitting height 1.9 13.3 18.1 -3.1 4.0 -3.1 -4.3 -3.7
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 0.6 0.1 -0.5 -0.3 -0.4
High blood pressure (mother) 0.3 0.5 1.6 1.3 -0.5 0.6 0.0 0.4
Body mass index (BMI) 1.9 8.1 13.5 3.7 -2.8 2.4 2.7 2.6
Impedance of leg (left) 0.1 0.5 0.9 -0.2 -0.5 0.9 0.9 0.9
Leg predicted mass (left) 0.9 4.6 7.9 -0.5 2.2 -2.0 -2.8 -2.4
Trunk fat mass 0.6 2.6 7.5 2.7 -1.3 1.2 1.1 1.1
Waist circumference 0.2 0.6 2.5 1.6 0.1 -0.3 -0.4 -0.1
Number of incorrect matches in round 0.0 0.0 0.0 -0.2 -0.0 0.1 0.2 0.1
Past tobacco smoking 3.9 7.2 10.1 2.0 -2.3 3.0 3.2 2.8
Alcohol usually taken with meals 0.9 1.5 2.5 1.0 -1.2 1.6 1.2 1.0
Nervous feelings 0.4 0.8 3.3 -1.8 0.1 -0.4 0.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 1.8 0.7 -1.1 1.0 1.3 1.3
Hearing difficulty/problems with background noise 2.4 3.9 5.4 -0.1 -2.3 1.9 2.3 2.3
Hair/balding pattern: Pattern 2 1.3 1.7 2.5 -1.6 1.1 -1.3 -1.2 -1.2
Had menopause 15.6 19.5 22.6 4.0 -4.7 4.1 4.8 4.5
Had other major operations 6.8 8.3 12.1 3.5 -2.4 2.9 2.7 2.7
Forced vital capacity (FVC) 0.2 0.9 1.5 0.8 -1.2 1.2 0.4 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 1.9 0.4 -0.8 1.2 1.4 1.3
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.7 -0.3 1.9 -1.1 -1.7 -1.4
Qualifications: None of the above 0.1 0.3 0.5 0.7 -0.3 0.3 0.6 0.6
Financial difficulties in last 2 years 0.9 1.2 3.4 1.8 -0.7 0.8 0.6 1.0
Mouth/teeth dental problems 0.8 1.2 2.1 0.6 -1.5 1.0 1.1 1.1
Heart attack 1.7 2.1 2.7 1.3 -1.3 1.7 1.5 1.6
Allergy 7.9 18.2 24.2 -3.4 4.9 -4.1 -4.4 -4.3
Pain all over the body in last month 1.3 1.4 2.3 1.2 -1.5 1.2 1.0 0.9
Diabetes (self-reported) 0.6 0.9 2.9 1.7 -0.6 0.5 0.8 0.7
Hayfever/allergic rhinitis (self-reported) 5.6 7.4 9.3 2.3 -3.1 2.7 2.8 2.7
Medication: Ramipril 4.9 6.3 8.3 1.9 -2.9 2.3 2.6 2.7
Medication: Simvastatin 2.2 3.3 4.4 1.5 -2.1 1.6 1.9 1.9
Fluid intelligence score 0.0 0.1 0.2 -0.4 -0.2 0.0 0.2 0.1
Illnesses of siblings 3.6 5.1 7.7 -1.8 2.8 -1.9 -2.3 -2.4
Neuroticism score 1.3 2.7 3.4 1.4 -1.8 1.3 1.8 1.8
Weight 0.1 0.4 1.5 1.2 0.2 -0.2 -0.7 -0.3
Impedance of arm (right) 0.1 0.4 1.9 -1.4 -0.0 -0.4 -0.2 -0.2
Arm fat percentage (right) 2.6 10.2 14.6 3.8 -3.3 2.7 3.1 2.9
Trunk fat-free mass 1.8 10.5 18.3 -1.0 3.7 -2.8 -4.3 -3.5
Hip circumference 0.1 0.4 0.9 1.0 -0.7 0.3 0.4 0.5
Time employed in main current job 4.3 4.9 6.2 -1.5 2.5 -2.3 -2.4 -2.3
Alcohol intake versus 10 years previously 0.4 0.7 1.6 1.3 -0.5 0.7 0.6 0.7
Father’s age at death 1.4 1.9 3.1 0.7 1.6 -1.1 -1.5 -1.8
Worrier / anxious feelings 1.6 3.0 3.6 1.9 -1.8 1.6 1.6 1.8
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.6 1.4 -1.2 0.8 1.6 1.4
Falls in the last year 0.3 0.4 1.1 1.0 -0.6 0.5 0.4 0.4
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.1 -0.8 0.4 0.7 0.6
Number of live births 0.9 1.2 2.1 0.7 -1.4 1.0 1.1 1.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.2 1.8 -1.5 1.4 0.5 1.0
Pulse rate 0.2 0.3 0.7 -0.0 0.8 -0.4 -0.6 -0.6
Happiness 0.2 0.2 0.5 -0.2 0.7 -0.2 -0.5 -0.3
Noisy workplace 0.0 0.0 0.0 0.2 -0.2 -0.1 0.1 0.0
Qualifications: A levels/AS levels or equivalent 0.5 1.2 1.7 1.0 -1.1 1.3 1.0 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.5 -0.7 0.3 -0.6 0.0 -0.0
Mouth/teeth dental problems: Dentures 0.3 0.5 0.7 0.2 0.7 -0.8 -0.7 -0.7
Asthma 2.4 4.7 6.2 2.4 -2.5 1.8 2.1 2.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 2.5 -1.3 1.6 -1.3 -1.6 -1.2
Medication: Cholesterol lowering 8.5 13.2 15.7 3.5 -4.0 3.6 3.5 3.6
Depression (self-reported) 0.1 0.1 0.3 -0.5 -0.1 -0.4 0.1 -0.0
Medication: Lansoprazole 1.2 1.3 1.9 1.2 -1.4 1.1 1.0 1.1
Prospective memory result 0.0 0.0 0.1 -0.0 0.3 -0.1 0.1 0.0
Lung cancer (father) 0.8 0.9 1.8 -0.7 1.4 -0.9 -0.9 -0.8
Illnesses of mother 1.3 1.7 2.6 -0.7 1.6 -1.3 -1.3 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 3.5 1.9 -1.9 1.6 1.0 1.4
Pulse wave Arterial Stiffness index 1.6 1.9 2.3 1.3 -1.3 1.2 1.5 1.4
Impedance of arm (left) 0.1 0.4 1.8 -1.4 -0.3 -0.2 0.2 0.0
Arm fat mass (right) 1.2 5.0 10.0 3.2 -2.1 1.8 1.8 1.9
Trunk predicted mass 1.8 10.0 17.8 -0.9 3.6 -2.6 -4.2 -3.4
Standing height 3.6 36.0 51.8 -4.8 6.3 -5.3 -7.2 -6.1
Length of working week for main job 1.1 1.2 2.1 -0.1 1.4 -1.0 -1.3 -1.2
Exposure to tobacco smoke at home 3.5 3.9 4.4 1.9 -1.9 2.1 1.9 2.0
Breastfed as a baby 0.1 0.2 0.4 -0.6 0.1 -0.4 -0.3 -0.1
Tense / ‘highly strung’ 0.6 1.1 1.7 0.1 -1.3 0.9 1.2 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.1 -0.6 -0.3 0.5 0.6
Hair/balding pattern: Pattern 4 0.2 0.6 1.0 -1.0 0.7 -0.7 -0.6 -0.8
Birth weight of first child 7.3 13.3 17.0 -2.5 4.0 -3.5 -4.1 -3.9
Peak expiratory flow (PEF) 0.1 0.3 1.0 -0.1 0.1 -0.4 -1.0 -0.6
Pulse wave reflection index 1.9 2.3 2.7 1.6 -1.6 1.5 1.4 1.4
Ever highly irritable/argumentative for 2 days 2.3 2.8 4.4 2.1 -1.5 1.9 1.2 1.5
Loud music exposure frequency 0.0 0.0 0.1 -0.0 -0.2 0.3 -0.1 -0.0
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 2.7 1.4 -1.4 1.6 1.3 1.5
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.9 -0.0 -0.9 1.1 1.4 1.4
Blood clot in the leg (DVT) 1.9 2.4 2.8 1.3 -1.6 1.5 1.7 1.7
Medication: Paracetamol 0.1 0.2 0.4 0.2 0.4 -0.2 -0.7 -0.4
Headache pain in last month 0.9 1.6 4.3 2.1 -1.1 1.2 0.7 0.8
Medication for cholesterol, blood pressure or diabetes 7.9 13.1 15.6 -3.2 3.9 -3.6 -3.6 -3.7
Glaucoma (self-reported) 1.0 1.1 1.7 0.2 -1.0 1.1 1.3 1.3
Gout (self-reported) 2.9 4.0 4.7 -1.6 1.8 -2.1 -2.1 -2.2
Hypothyroidism/myxoedema (self-reported) 1.9 3.8 5.3 2.3 -1.6 1.8 1.9 2.0
Medication: Amlodipine 2.3 3.3 5.1 1.3 -2.3 1.6 1.9 1.9
Medication: Ventolin 100micrograms inhaler 5.3 6.8 8.5 2.2 -2.9 2.5 2.7 2.6
Birth weight 1.2 2.7 4.2 -0.3 2.0 -1.4 -2.1 -1.7
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.6 0.9 -1.6 1.3 1.1 1.0
High blood pressure (siblings) 5.0 7.2 9.2 2.5 -3.0 2.5 2.6 2.7
Forced vital capacity (FVC), Best measure 0.7 2.5 4.0 1.1 -2.0 1.8 1.3 1.5
Body fat percentage 2.5 9.9 14.7 3.8 -3.2 2.7 3.0 2.9
Leg fat percentage (right) 4.6 16.6 23.3 4.8 -3.9 3.7 4.0 3.8
Arm fat-free mass (right) 0.9 4.6 8.1 -0.3 2.5 -1.7 -2.8 -2.3
Exposure to tobacco smoke outside home 0.3 0.4 0.8 -0.5 0.6 -0.4 -0.9 -0.7
Comparative body size at age 10 3.0 8.3 10.6 3.3 -2.9 2.5 2.9 2.8
Number of full brothers 0.2 0.2 0.7 0.9 -0.2 0.4 -0.1 0.1
Worry too long after embarrassment 0.9 1.4 2.6 0.5 -1.6 0.7 1.5 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.1 -0.0 -0.2 -0.0 0.2
Wheeze or whistling in the chest in last year 0.3 0.5 0.8 0.4 -0.9 0.5 0.7 0.9
Number of children fathered 1.8 2.1 3.5 0.3 1.9 -1.0 -1.8 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 6.6 -2.6 0.6 -1.3 -1.1 -1.3
Age at first live birth 0.2 0.4 0.6 -0.5 0.6 -0.5 -0.8 -0.8
Pulse wave peak to peak time 2.6 3.0 3.8 -1.7 1.7 -1.6 -1.9 -1.8
Health satisfaction 1.9 2.4 2.9 1.1 -1.7 1.7 1.5 1.7
Shortness of breath walking on level ground 3.2 3.7 4.9 2.2 -1.9 2.1 1.6 1.8
Qualifications: College or University degree 0.1 0.2 0.4 -0.4 0.3 -0.1 -0.5 -0.6
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.3 0.4 -0.5 -0.5 -0.6
Mouth/teeth dental problems: Loose teeth 4.7 5.6 8.0 -1.9 2.8 -2.3 -2.6 -2.2
Emphysema/chronic bronchitis 0.1 0.2 0.3 0.2 -0.6 0.2 0.6 0.3
Medication for pain relief, constipation, heartburn 1.4 2.4 4.6 -2.1 1.5 -1.4 -1.1 -1.4
Neck or shoulder pain in last month 2.5 3.6 4.9 1.3 -1.9 2.2 1.8 2.1
Medication: Blood pressure 2.6 4.5 5.4 2.1 -2.3 2.0 2.1 2.1
Angina (self-reported) 4.3 5.7 8.3 2.9 -2.1 2.5 2.1 2.2
Migraine (self-reported) 0.2 0.2 0.4 0.0 0.6 -0.3 -0.6 -0.4
Medication: Ibuprofen 1.3 1.5 2.0 -1.3 1.4 -1.0 -1.4 -1.0
Medication: Allopurinol 1.1 1.4 1.5 -1.1 1.2 -1.2 -1.2 -1.2
Medication: Omeprazole 7.2 8.6 10.1 2.8 -3.2 2.8 3.0 2.9
Medication: Seretide 50 evohaler 0.6 0.6 1.8 -0.2 -1.3 0.4 0.8 0.8
Mean time to correctly identify matches 0.2 0.5 1.0 1.0 0.7 -0.5 -0.4 -0.6
Heart disease (mother) 1.3 1.6 2.1 1.4 -1.4 1.2 1.1 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 0.4 -0.2 0.5 0.6 0.7
Whole body fat mass 0.9 3.8 9.1 3.0 -1.8 1.5 1.5 1.5
Leg fat mass (right) 1.9 7.4 14.5 3.8 -2.5 2.4 2.3 2.3
Arm predicted mass (right) 1.2 6.4 11.1 -0.4 3.0 -2.1 -3.3 -2.7
Pulse rate, automated reading 0.3 1.1 2.0 -0.3 1.4 -0.9 -1.1 -1.2
Alcohol intake frequency. 5.4 12.6 21.3 4.6 -2.9 3.5 3.0 3.3
Comparative height size at age 10 1.4 7.5 9.2 -2.8 2.7 -2.6 -3.0 -2.6
Number of full sisters 0.0 0.0 0.1 0.0 0.2 -0.3 -0.3 -0.2
Suffer from ‘nerves’ 0.8 1.3 2.6 -0.3 -1.3 0.6 1.6 1.4
Overall health rating 2.1 4.6 5.3 2.2 -2.2 1.7 2.3 2.3
Chest pain or discomfort 3.7 5.3 6.0 2.1 -2.4 2.3 2.2 2.4
Had major operations 1.3 1.5 1.9 0.8 -1.2 1.3 1.3 1.4
Age at last live birth 2.7 3.9 4.6 -1.6 2.0 -2.0 -2.1 -2.1
Family relationship satisfaction 0.5 0.6 0.9 0.8 -0.6 1.0 0.5 0.8
Leg pain on walking 1.4 1.8 3.7 1.9 -1.2 1.2 1.0 1.0
Qualifications: NVQ or HND or HNC or equivalent 3.3 4.0 5.1 -1.9 2.2 -2.1 -1.9 -1.8
Commuting to job workplace: Car/motor vehicle 1.5 1.7 2.7 1.6 -1.2 1.4 1.2 1.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.0 0.4 -0.6 1.0 0.6 0.4
Medication: Aspirin 3.4 4.5 7.6 2.8 -2.1 2.1 1.7 1.8
Supplements: Vitamin C 0.6 0.8 1.1 0.7 -0.9 1.0 0.8 0.9
Knee pain experienced in last month 0.3 0.5 2.0 1.4 -0.2 0.6 0.3 0.5
Hypertension (Self-reported) 7.8 21.7 30.7 3.3 -5.5 4.3 4.9 4.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 0.4 -0.7 0.2 0.4 0.3
Illnesses of father: Heart disease 6.2 8.5 10.2 2.3 -3.1 3.0 3.2 2.8
Illnesses of siblings: Diabetes 0.0 0.0 0.0 -0.1 -0.1 -0.0 -0.1 0.2
Smoking status: Previous 2.3 3.4 5.2 -1.2 1.6 -2.1 -2.3 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.2 -1.5 0.6 -0.5 -1.2 -0.8
Whole body fat-free mass 1.6 9.1 15.4 -1.1 3.3 -2.7 -3.9 -3.2
Leg fat-free mass (right) 1.4 7.3 11.2 -1.5 2.8 -2.7 -3.3 -2.9
Arm fat percentage (left) 2.6 10.4 14.1 3.8 -3.4 2.7 3.2 3.0
Average weekly red wine intake 3.0 4.4 5.3 -2.3 1.9 -2.0 -2.1 -2.2
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.7 -0.3 0.7 -0.0 0.0
Mood swings 0.6 1.1 1.6 0.8 -0.9 0.8 1.2 1.3
Loneliness, isolation 0.8 1.1 1.6 0.7 -0.9 1.0 1.2 1.3
Long-standing illness, disability or infirmity 8.4 12.9 15.0 3.2 -3.7 3.3 3.9 3.8
Ever had bowel cancer screening 0.3 0.3 0.7 -0.0 0.5 -0.5 -0.8 -0.6
Diabetes diagnosed by doctor 0.7 1.2 3.0 1.7 -1.0 0.5 0.9 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.4 0.5 -1.4 0.9 1.6 1.4
Friendships satisfaction 1.7 2.1 3.5 1.9 -1.1 1.7 1.1 1.4
Qualifications: nursing, teaching 0.4 0.6 0.8 -0.6 0.7 -0.9 -0.7 -0.8
Commuting to job workplace: Walk 4.7 5.0 5.9 -1.9 2.4 -2.4 -2.2 -2.3
Eye problems/disorders: Cataract 0.0 0.0 0.1 -0.2 -0.0 -0.4 0.1 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 4.1 -1.3 2.0 -1.5 -1.5 -1.5
Medication for cholesterol 3.4 5.1 7.1 -1.4 2.7 -2.0 -2.6 -2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 7.1 8.3 9.8 3.1 -2.9 2.5 2.9 2.8
Back pain experienced in last month 0.4 0.7 2.6 1.6 -0.5 0.6 0.0 0.3
Mineral and other dietary supplements 1.3 1.8 3.0 0.4 -1.5 1.1 1.7 1.5
Breast cancer (self-reported) 1.1 1.4 2.4 -0.3 -1.5 0.8 1.5 1.1
Asthma (self-reported) 2.4 4.8 6.2 2.3 -2.5 1.8 2.2 2.1
Osteoporosis (self-reported) 4.0 4.9 7.0 1.4 -2.7 2.1 2.6 2.1
Osteoarthritis (self-reported) 1.3 1.7 6.2 2.5 -0.4 1.2 0.4 0.6
Medication: Aspirin 3.9 5.0 7.3 2.7 -2.1 2.3 2.0 2.1
Medication: Gliclazide 0.4 0.5 2.2 1.5 0.1 0.1 0.3 0.4
Illnesses of father: None of the above (group 1) 4.8 5.9 8.2 -1.8 2.9 -2.3 -2.6 -2.4
Smoking status: Current 1.5 2.4 3.3 -1.2 1.8 -1.7 -1.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.4 9.3 10.6 3.0 -3.3 3.0 2.9 3.0
Whole body water mass 1.5 8.6 14.6 -1.0 3.2 -2.6 -3.8 -3.1
Leg predicted mass (right) 1.4 7.4 11.3 -1.5 2.8 -2.7 -3.4 -2.9
Arm fat mass (left) 1.2 4.9 9.4 3.1 -2.2 1.8 1.9 1.9
Number of self-reported non-cancer illnesses 2.8 4.9 6.5 2.2 -2.5 1.9 2.1 2.2
Average weekly champagne plus white wine intake 0.6 0.8 1.4 -0.2 0.9 -0.7 -1.2 -1.1
Miserableness 1.0 1.7 2.2 1.3 -1.3 1.0 1.4 1.5
Guilty feelings 0.2 0.3 0.5 0.6 -0.6 0.4 0.4 0.7
Wears glasses or contact lenses 0.5 0.6 1.2 1.1 -0.9 0.8 0.5 0.3
Ever taken oral contraceptive pill 1.2 1.4 4.3 -2.1 0.7 -1.0 -0.8 -0.7
Hearing aid user 1.2 1.4 1.8 1.2 -0.9 1.2 1.2 1.3
Mother’s age at death 0.1 0.1 0.3 0.2 -0.4 0.5 0.3 0.1
Financial situation satisfaction 0.8 1.0 1.6 0.4 -1.0 1.1 1.0 1.2
Tinnitus: Yes, now most or all of the time 2.6 3.0 4.2 2.1 -1.9 1.6 1.4 1.6
Commuting to job workplace: Public transport 1.3 1.5 2.0 1.3 -1.4 1.2 1.1 1.1
Eye problems/disorders: Glaucoma 1.7 2.0 2.6 0.9 -1.4 1.5 1.6 1.6
Medication: Blood pressure 7.0 13.4 16.9 2.9 -4.1 3.5 3.9 3.8
Pain type(s) experienced in last month: Hip pain 5.2 6.6 11.4 3.4 -2.1 2.5 2.4 2.2
Supplements: Fish oil (including cod liver oil) 1.1 1.5 2.2 -0.4 1.4 -1.1 -1.5 -1.3
High cholesterol (Self-reported) 4.3 7.6 9.4 1.5 -3.1 2.8 3.0 3.0
Medication: Bendroflumethiazide 2.4 3.6 4.8 2.2 -2.0 1.6 1.9 1.7
Medication: Paracetamol 0.1 0.2 0.4 -0.1 0.4 -0.3 -0.6 -0.5
Medication: Lisinopril 2.9 3.7 4.6 1.3 -2.0 2.0 2.1 2.1
Medication: Atorvastatin 11.7 14.4 16.3 3.4 -3.8 3.8 4.0 4.0
Illnesses of father: High blood pressure 4.7 5.8 7.9 1.4 -2.8 2.4 2.6 2.6
Alcohol drinker status: Never 14.1 16.9 19.0 4.4 -3.7 4.3 4.1 4.1
Ever smoked 4.5 8.0 11.0 -2.1 2.6 -3.0 -3.3 -2.9
Basal metabolic rate 1.0 5.6 10.0 -0.5 2.6 -2.1 -3.2 -2.6
Leg fat percentage (left) 3.6 13.2 16.5 4.1 -3.6 3.3 3.7 3.5
Arm fat-free mass (left) 0.8 4.2 7.8 -0.0 2.4 -1.7 -2.8 -2.1
Number of operations (self-reported) 2.7 4.1 7.4 2.7 -1.6 2.0 1.7 1.8
Average weekly beer plus cider intake 3.5 5.1 6.1 -2.1 2.3 -2.2 -2.5 -2.1
Irritability 0.1 0.2 0.8 0.9 0.1 0.1 -0.4 -0.4
Risk taking 1.0 1.5 1.9 -1.3 1.4 -1.0 -1.4 -1.1
Ever had prostate specific antigen (PSA) test 3.0 3.5 4.8 -1.3 1.9 -1.8 -2.2 -1.9
Fractured/broken bones in last 5 years 0.4 0.6 1.1 -1.0 0.6 -0.7 -0.7 -0.6
Age started oral contraceptive pill 1.8 2.2 5.1 2.3 -1.2 1.6 1.0 1.0
Diastolic blood pressure, automated reading 10.6 32.7 37.9 4.7 -6.2 5.5 6.1 6.1
Ever depressed for a whole week 0.1 0.2 0.3 0.4 0.4 -0.2 -0.6 -0.3
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.1 0.4 -0.5 -0.4 -0.3
Commuting to job workplace: Cycle 5.8 7.0 8.7 -2.5 3.0 -2.6 -2.6 -2.5
Myopia 0.1 0.2 0.3 -0.4 0.2 -0.5 -0.5 -0.5
Vascular/heart problems diagnosed by doctor 9.0 24.7 33.8 -3.7 5.8 -4.6 -5.2 -5.2
Cholesterol lowering medication 2.2 3.2 4.8 1.1 -1.9 1.6 2.2 2.0
Medication: Omeprazole (e.g. Zanprol) 6.3 7.7 9.1 2.5 -3.0 2.6 2.9 2.8
Pain experienced in last month 2.9 4.8 8.8 -3.0 2.0 -2.2 -1.6 -1.9
Supplements: Calcium 0.1 0.1 0.2 -0.5 0.3 -0.3 -0.3 -0.3
Basal cell carcinoma (self-reported) 0.7 0.9 1.6 1.2 0.8 -0.1 -1.1 -0.9
Heart attack/myocardial infarction (self-reported) 1.4 1.9 2.3 1.2 -1.2 1.5 1.4 1.5
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 3.2 1.4 -1.6 1.6 1.8 1.8
Heart disease (siblings) 2.4 2.9 4.5 1.5 -2.1 1.6 1.6 1.7
Alcohol drinker status: Previous 0.5 0.6 1.0 -1.0 0.7 -0.7 -0.8 -0.6
Pack years of smoking 1.2 1.8 5.2 2.3 -1.0 1.1 0.7 0.9
Impedance of whole body 0.1 0.3 1.0 -1.0 -0.3 0.2 0.4 0.3
Leg fat mass (left) 1.7 6.6 11.8 3.4 -2.4 2.3 2.2 2.3
Arm predicted mass (left) 0.7 3.7 7.2 0.2 2.2 -1.5 -2.7 -2.0