Hub : Genes

PTPLAD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1300 0.0580 4.2e-04 0.100 NA 0.081 NA 0.026 7.5e-06 NA 5.5e-05 NA 1.6e-02
2 GTEx Cells EBV-transformed lymphocytes 0.1760 0.0540 1.5e-05 0.179 NA 0.147 NA 0.048 1.8e-06 NA 1.7e-05 NA 1.1e-02
3 GTEx Nerve Tibial 0.0851 0.0375 1.3e-03 0.020 NA 0.022 NA 0.028 1.4e-02 NA 9.9e-03 NA 4.4e-03
4 METSIM Adipose 0.0594 0.0238 2.9e-05 0.021 0.029 0.016 0.03 0.022 3.6e-04 2.7e-05 1.8e-03 2e-05 2.8e-04
5 TCGA Breast Invasive Carcinoma 0.0353 0.0197 2.2e-05 0.024 0.016 0.022 NA 0.021 8.1e-06 2.8e-04 2.3e-05 NA 2.8e-05
6 TCGA Cervical Squamous Cell Carcinoma 0.0880 0.0510 1.5e-03 0.058 0.062 0.044 NA 0.053 7.8e-04 5.2e-04 3.0e-03 NA 1.3e-03
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0536 0.0373 4.8e-03 0.011 0.013 0.017 NA 0.009 1.6e-02 1.1e-02 4.3e-03 NA 2.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.2 1.9 5.6 1.6 -0.3 -0.1 0.6 2.4 0.2 2.1
Bipolar Disorder or Schizophrenia 0.5 1.1 5.4 0.6 -0.1 -0.3 -0.1 2.3 0.2 1.5
Depressed Affect (Nagel 2018) 0.2 0.5 1.5 1.0 -0.2 -0.4 -0.3 1.2 -0.7 -0.3
Depression (Nagel 2018) 0.3 0.4 1.9 0.4 -0.3 -0.0 0.3 1.4 -0.4 0.5
Intelligence (Savage-Jansen 2018) 1.3 4.1 10.7 3.0 -2.3 0.0 0.7 -0.3 -3.3 -1.7
Neuroticism (Nagel 2018) 0.3 0.8 1.9 1.3 -0.6 0.1 0.6 1.4 -1.1 0.4
Schizophrenia (2018) 0.1 0.3 1.1 -0.6 0.1 -0.3 -0.6 1.1 0.1 0.1
Schizophrenia vs Biploar Disorder 0.2 0.3 1.0 -0.3 -0.3 0.3 -0.5 -0.4 -0.6 -1.0
Worry (Nagel 2018) 0.1 0.2 0.7 0.9 0.1 -0.5 0.1 0.4 -0.3 -0.4
Alzheimer’s Disease (in mother) 0.9 1.0 3.8 2.0 -0.6 -0.5 0.7 -0.3 -1.1 -1.0
Alzheimer’s Disease (in father) 0.4 0.4 0.8 -0.4 0.7 -0.9 -0.0 0.8 0.8 0.5
Alzheimer’s Disease (including proxy) 0.2 0.3 1.1 0.8 0.6 -1.0 0.0 -0.2 0.2 -0.5
Crohns Disease (2017) 0.5 1.2 2.9 0.1 0.1 0.8 1.5 1.3 0.8 1.7
Irritable Bowel Disease (IBD) 0.8 2.0 3.9 1.2 -0.8 0.9 1.9 2.0 -0.5 1.7
Ulcerative Colitis (UC) 0.8 1.5 2.4 1.5 -1.3 0.6 1.3 1.4 -1.4 0.7
Major Depression (MDD) 1.5 1.8 3.9 -2.0 0.8 0.9 -0.0 1.6 1.3 1.7
Reaction Time 0.2 0.4 0.9 0.2 -0.5 0.6 -0.5 1.0 -0.2 0.8
Verbal and Numeric Reasoning (VNR) 0.9 2.3 5.5 2.3 -1.0 -1.0 0.0 -1.0 -1.8 -2.0
Breast Cancer 0.5 1.3 3.3 0.9 -0.9 0.2 0.0 -1.2 -1.5 -1.8
Ovarian Cancer 0.6 0.8 3.3 0.9 -0.4 0.1 0.4 1.8 -0.3 1.0
Prostate Cancer 0.8 1.1 2.3 -1.0 1.2 -0.8 -1.5 0.4 1.4 0.5
Age at First Birth 1.4 2.1 3.6 1.8 -1.9 0.6 1.6 0.9 -1.9 0.3
Bipolar Disorder (2011) 1.3 1.3 3.8 0.3 -0.6 1.3 0.7 1.5 0.1 2.0
Body Mass Index (BMI) (2010) 1.2 1.6 3.8 -1.1 1.0 -0.3 -0.2 1.4 1.8 1.9
Coronary Artery Disease (CAD) 0.8 1.0 3.6 1.3 -0.4 0.2 0.1 1.9 -0.2 1.1
Crohns Disease (2012) 1.1 1.8 4.5 0.6 -0.8 1.9 2.1 0.9 -0.0 1.7
Mean Putamen Volume 0.8 0.9 2.1 -0.6 1.0 -0.2 0.0 1.0 1.3 1.5
Fasting Glucose 1.1 1.3 2.5 0.7 -1.5 1.4 1.6 0.3 -1.4 -0.0
HbA1C 1.0 1.2 1.8 1.3 -1.3 0.5 1.3 0.8 -1.4 0.4
HDL Cholesterol 1.7 2.9 5.0 1.7 -2.1 1.7 1.1 -1.3 -2.2 -1.5
LDL Cholesterol 0.2 0.4 0.6 0.6 -0.8 0.6 0.4 0.7 -0.8 0.2
Lupus 1.0 1.5 3.9 0.6 -1.5 1.3 2.0 -0.3 -1.4 0.1
Neuroticism (2016) 0.6 0.9 2.0 1.4 -0.6 0.4 1.3 1.0 -1.1 0.3
Primary Biliary Cirrhosis 0.2 0.3 0.9 0.6 -0.4 0.7 0.9 -0.3 -0.1 0.2
Rheumatoid Arthritis 0.4 0.6 1.5 -0.4 1.0 -0.8 -1.2 -0.2 0.8 -0.4
Schizophrenia (2014) 0.1 0.2 0.8 -0.2 -0.2 -0.4 -0.4 0.9 -0.4 -0.0
Triglycerides 0.5 0.9 3.1 0.8 -1.0 0.2 -0.1 1.8 -0.9 0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.1 -0.7 0.6 -0.3 0.5 0.2 1.0 0.5
Ulcerative Colitis 0.3 0.5 1.4 1.2 -0.6 0.2 0.7 0.2 -1.0 -0.2
Blood Eosinophil Count 1.4 10.5 19.4 -3.4 4.4 -3.3 -3.8 -0.1 4.2 -0.2
Blood Platelet Count 0.5 5.3 15.4 -1.2 2.0 -3.4 -3.9 1.7 1.5 -0.2
Blood Red Count 11.4 110.0 222.0 11.9 -14.1 9.2 9.9 -1.7 -14.9 -4.6
Blood White Count 0.4 3.0 12.9 1.8 -1.5 -0.4 -0.3 3.6 -1.3 0.8
Heel T-Score 5.1 40.2 93.7 -8.4 7.9 -2.3 -3.5 1.5 9.7 5.9
BMI 0.7 4.1 11.2 -1.4 -0.9 3.3 2.4 1.0 0.5 2.8
Height 0.9 16.6 44.1 3.8 -3.1 -1.6 -1.3 -3.2 -5.8 -6.6
Waist Hip Ratio (WHR) 0.5 2.0 4.2 -2.0 1.5 -1.5 -1.1 -1.4 0.8 -1.4
Systolic Blood Pressure 0.6 3.2 7.3 -1.9 2.2 -1.1 -1.6 1.0 2.7 1.4
Smoking Status 1.3 3.2 8.5 0.5 -2.0 2.9 2.4 -0.8 -1.8 -0.4
Allergy or Eczema 0.3 0.7 2.0 1.4 -0.5 -0.6 0.2 0.4 -1.1 -1.0
Cardiovascular Disease 0.9 2.9 7.0 -0.5 -0.9 1.7 1.9 2.4 0.3 2.7
Hypothyroidism (self reported) 1.4 3.2 11.2 -0.2 -0.1 1.2 1.3 2.5 1.1 3.3
Respiratory disease 0.3 0.6 1.0 0.9 -0.8 1.0 0.7 -0.3 -1.0 -0.8
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.9 0.2 -1.7 1.2 0.7 0.5 -1.3 -0.1
Lung FEV1/FVC ratio 0.5 2.7 7.0 -0.8 1.2 -0.9 -0.3 2.6 1.7 2.5
Lung FVC 0.1 0.7 2.1 0.0 -0.7 0.8 0.2 -1.4 -0.8 -1.0
Neuroticism 0.2 0.5 1.3 1.2 -0.6 0.2 0.3 0.8 -1.0 -0.3
Chronotype (morning person) 0.2 0.5 2.2 -0.1 -0.1 1.5 -0.2 -0.1 0.3 1.1
Hair Pigment 0.1 3.6 11.2 -1.8 1.7 -1.1 -1.4 -3.3 0.9 -2.0
Tanning 0.4 4.3 11.6 -0.1 -0.9 3.0 2.4 1.6 0.4 3.4
Hand grip strength (left) 0.8 2.1 8.5 0.4 0.1 -0.5 -0.1 -2.4 -0.6 -2.9
Number of treatments/medications taken 1.8 3.2 5.9 0.6 -1.9 2.4 2.3 1.7 -1.2 1.4
Average weekly spirits intake 0.5 0.6 1.9 -0.5 1.0 -0.8 -0.6 0.3 1.4 0.0
Sensitivity / hurt feelings 2.4 4.2 7.6 -1.6 2.6 -2.0 -1.8 1.8 2.8 1.4
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.9 0.6 -0.5 0.0 0.5 2.0 -0.6 0.8
Hearing difficulty/problems: Yes 0.9 1.3 6.5 -0.3 0.3 -0.9 -0.7 2.5 0.2 1.2
Relative age of first facial hair 0.4 0.9 2.0 1.0 -1.1 0.4 1.4 0.6 -1.2 0.1
Other serious medical condition/disability diagnosed by doctor 2.1 2.8 4.8 0.3 -1.8 2.2 2.0 1.6 -1.5 1.6
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.3 0.6 -0.9 0.7 0.2 -0.8 -1.1 -1.0
Ever had hysterectomy (womb removed) 0.4 0.4 1.3 -0.0 0.4 -1.1 -1.0 0.0 -0.2 -0.7
Systolic blood pressure, automated reading 0.8 2.3 4.1 -1.5 2.0 -1.6 -1.7 -0.7 1.9 -0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.2 1.1 -0.6 -0.8 0.1 0.0 -1.1 -1.1
Angina 0.3 0.4 1.4 0.2 -0.4 -0.2 0.9 1.2 -0.6 0.2
Medication for hormone replacement therapy 1.1 1.2 2.4 -1.6 1.2 -0.5 -0.7 -1.6 1.2 -0.6
Vitamin and mineral supplements 3.3 4.5 11.3 -3.4 2.5 -1.1 -2.0 -1.8 2.2 -0.9
Supplements: Zinc 1.6 1.7 2.9 0.6 -1.0 1.6 1.7 1.6 -0.4 1.7
Medication: Co-codamol 1.0 1.2 1.9 0.9 -1.2 0.9 1.1 -0.5 -1.4 -1.2
Medication: Metformin 1.1 1.5 3.5 0.7 -1.9 1.6 1.4 0.1 -1.4 0.2
Diabetes (father) 2.7 3.4 6.2 2.0 -2.4 1.0 2.0 1.6 -2.5 0.4
Diabetes (mother) 0.6 0.7 3.1 -0.6 0.3 -0.3 -1.8 -0.8 0.1 -0.9
Severe depression (siblings) 0.2 0.2 0.6 0.3 -0.6 0.3 0.8 0.2 -0.7 0.2
Pack years adult smoking proportion 0.8 1.2 2.9 -1.0 1.1 0.3 -0.1 1.0 1.6 1.7
Impedance of leg (right) 0.3 1.4 3.6 0.6 0.6 -1.6 -1.2 -1.1 -0.2 -1.9
Leg fat-free mass (left) 0.1 0.4 0.9 0.0 -0.8 0.8 0.4 -0.3 -1.0 -0.5
Trunk fat percentage 0.4 1.5 3.2 -1.8 0.5 1.6 1.2 0.5 1.0 1.4
Hand grip strength (right) 0.8 2.1 8.4 0.7 -0.7 -0.6 0.1 -1.8 -1.4 -2.9
Townsend deprivation index at recruitment 0.9 1.3 3.4 0.2 -0.5 1.2 1.5 1.2 -0.2 1.9
Current tobacco smoking 0.2 0.3 1.5 -0.4 -0.2 1.2 0.6 -0.4 0.2 0.4
Average weekly fortified wine intake 0.1 0.1 0.5 0.3 -0.1 0.2 0.7 -0.5 -0.0 -0.5
Maternal smoking around birth 0.1 0.2 0.5 0.7 0.1 -0.6 0.4 0.2 -0.1 -0.1
Fed-up feelings 0.4 0.8 3.0 1.4 -0.3 -0.3 0.0 1.7 -0.5 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.6 -0.3 0.4 0.2 -0.2 0.8 0.3 0.7
Relative age voice broke 0.8 1.2 3.2 0.5 -1.2 1.4 1.8 -0.4 -1.0 -0.1
Taking other prescription medications 1.2 1.8 5.1 0.2 -1.6 2.3 1.8 0.7 -1.1 0.6
Age when periods started (menarche) 0.8 1.8 5.8 -0.9 1.6 0.1 0.2 0.3 2.4 1.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.6 0.2 0.3 -1.3 -0.9 -0.3 -0.3 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 3.1 7.0 16.7 -3.3 3.4 -1.1 -1.6 0.8 4.1 2.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.4 -0.2 0.0 0.2 -0.1 -0.3 -0.2
Qualifications: CSEs or equivalent 0.9 1.2 1.7 -0.5 1.1 -1.0 -1.0 1.2 1.3 1.2
Serious illness, injury or assault to yourself 0.9 1.1 3.1 -1.8 1.0 0.2 -1.5 0.2 1.1 0.1
High blood pressure 1.2 3.2 6.5 0.2 -1.3 1.9 2.2 2.4 -0.4 2.5
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.9 0.5 -0.0 -0.8 -0.2 -0.2 -0.6 -0.9
Multivitamins +/- minerals 2.7 3.5 6.7 2.6 -2.4 1.6 1.9 0.9 -2.2 0.3
Stomach or abdominal pain in last month 0.7 0.9 2.6 -0.2 -0.8 1.5 1.6 0.2 -0.5 0.4
Supplements: Glucosamine 0.4 0.6 1.7 0.1 -0.3 -0.0 -0.8 -1.3 -0.8 -0.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.0 1.4 -1.4 1.4 1.2 0.5 -1.1 0.2
Medication: Atenolol 0.1 0.1 0.4 -0.6 0.2 0.2 0.6 0.1 0.3 0.1
Medication: Levothyroxine sodium 1.2 2.0 4.1 1.0 -1.0 1.1 1.6 2.0 -0.4 2.0
Sitting height 0.8 5.7 14.7 0.8 0.7 -3.2 -3.0 -2.0 -1.1 -3.8
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 -0.0 -0.1 1.4 1.3 0.2 0.5 1.4
High blood pressure (mother) 1.3 1.9 4.5 -2.1 1.3 0.8 -0.2 0.7 1.9 1.5
Body mass index (BMI) 0.7 2.8 5.8 -2.4 0.4 2.0 1.1 0.9 1.5 2.3
Impedance of leg (left) 0.5 2.3 6.0 0.6 1.0 -2.1 -1.6 -1.4 -0.1 -2.4
Leg predicted mass (left) 0.1 0.4 1.0 0.1 -0.8 0.7 0.4 -0.2 -1.0 -0.4
Trunk fat mass 0.2 0.7 1.9 -1.3 0.1 1.4 1.0 0.1 0.4 0.6
Waist circumference 0.2 0.9 3.9 -2.0 0.3 1.2 0.3 -0.1 0.7 0.5
Number of incorrect matches in round 1.0 1.6 3.0 0.6 -1.7 1.7 1.5 0.2 -1.7 -0.3
Past tobacco smoking 1.0 1.8 3.5 -0.3 1.4 -1.9 -1.1 1.4 1.5 1.1
Alcohol usually taken with meals 0.7 1.2 3.2 1.2 -0.4 -0.2 -0.4 -1.8 -0.8 -1.7
Nervous feelings 0.2 0.4 1.3 0.3 0.7 -0.7 -0.5 1.1 0.5 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.4 0.8 0.3 -0.9 -0.6 1.2 -0.1 0.4
Hearing difficulty/problems with background noise 0.3 0.5 1.1 0.9 -1.0 0.4 0.5 0.3 -1.0 -0.2
Hair/balding pattern: Pattern 2 0.8 1.0 2.8 -1.2 0.5 0.8 1.7 0.0 0.9 1.1
Had menopause 1.2 1.5 3.6 1.2 -1.2 -0.2 0.5 -0.9 -1.7 -1.9
Had other major operations 0.5 0.6 1.3 -0.1 0.3 -1.0 -0.8 1.1 0.6 0.9
Forced vital capacity (FVC) 0.4 1.5 4.3 0.8 -0.3 -1.0 -1.5 -1.3 -0.9 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 10.0 -2.5 2.6 -0.4 -0.5 0.3 3.2 1.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.4 0.4 -0.7 1.2 0.8 -0.2 -0.6 -0.0
Qualifications: None of the above 0.5 1.0 3.1 -0.6 0.1 0.4 0.9 1.4 0.6 1.8
Financial difficulties in last 2 years 1.1 1.4 3.4 1.7 -1.5 0.0 -0.2 0.3 -1.8 -1.1
Mouth/teeth dental problems 3.3 5.0 8.8 -3.0 2.7 -1.1 -1.8 -2.6 2.7 -0.9
Heart attack 0.6 0.8 1.7 -1.3 0.9 -1.0 -0.8 0.7 0.9 -0.0
Allergy 0.3 0.6 1.3 -0.5 0.9 -0.7 -1.0 0.4 1.1 0.5
Pain all over the body in last month 0.4 0.4 0.7 -0.5 0.9 -0.7 -0.7 0.6 0.8 0.3
Diabetes (self-reported) 0.8 1.2 2.1 0.1 -1.5 1.4 1.2 -0.7 -1.4 -0.9
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 3.0 -0.2 1.1 -1.7 -1.2 -1.3 0.5 -1.4
Medication: Ramipril 0.8 1.1 3.0 -0.6 -0.1 0.3 0.9 1.7 0.5 1.7
Medication: Simvastatin 1.0 1.5 2.2 0.6 -1.4 1.1 1.4 1.5 -1.0 1.2
Fluid intelligence score 0.6 1.3 2.4 1.5 -0.6 -1.3 -0.8 -0.6 -1.3 -1.4
Illnesses of siblings 0.4 0.5 1.6 0.0 0.5 -1.3 -1.0 0.8 0.2 0.0
Neuroticism score 0.1 0.2 0.7 0.6 0.1 -0.2 -0.5 0.2 -0.5 -0.8
Weight 0.1 0.3 0.9 -0.8 -0.3 0.9 0.4 -0.3 -0.3 -0.3
Impedance of arm (right) 0.2 0.9 4.1 2.0 -0.5 -0.4 0.4 -0.4 -0.9 -0.8
Arm fat percentage (right) 0.6 2.4 5.7 -1.8 0.4 1.8 1.2 1.1 1.4 2.4
Trunk fat-free mass 0.3 1.9 5.6 0.9 -1.1 -0.3 -0.4 -1.4 -1.8 -2.4
Hip circumference 0.1 0.4 1.4 -1.2 0.1 1.0 -0.0 0.0 0.4 0.4
Time employed in main current job 0.2 0.3 1.5 -0.2 0.2 -0.4 -1.2 0.1 0.0 -0.5
Alcohol intake versus 10 years previously 2.6 3.8 6.2 -2.1 2.5 -2.2 -2.3 0.2 2.3 0.6
Father’s age at death 1.3 1.7 3.9 1.0 -2.0 1.3 1.2 -0.3 -1.9 -0.3
Worrier / anxious feelings 0.3 0.5 1.4 0.3 -0.6 0.6 0.5 1.2 -0.7 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.1 1.3 -1.0 0.0 -0.3 0.9 -1.4 -1.2
Falls in the last year 0.1 0.1 0.3 -0.3 0.2 -0.2 -0.3 0.6 0.1 0.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 -0.4 0.3 0.2 -0.5 -0.5 0.4 0.2
Number of live births 0.5 0.7 1.8 0.9 -1.4 0.5 0.3 0.7 -1.3 -0.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.6 0.8 -0.3 -1.0 -0.9 -0.5 -0.6 -1.3
Pulse rate 0.1 0.2 0.8 -0.2 0.5 -0.2 -0.9 0.3 0.2 -0.1
Happiness 0.8 0.9 1.4 -0.9 1.2 -1.1 -0.7 -0.9 0.7 -1.1
Noisy workplace 0.5 0.6 2.1 -1.4 0.7 0.8 0.1 -0.1 1.0 0.5
Qualifications: A levels/AS levels or equivalent 1.2 2.8 8.4 1.0 -0.6 -1.1 -0.6 -2.5 -1.3 -2.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 4.2 -0.8 0.3 -0.3 -0.6 -1.8 -0.4 -2.0
Mouth/teeth dental problems: Dentures 0.4 0.7 2.9 0.9 -0.1 -0.6 -0.0 1.7 -0.1 0.7
Asthma 0.3 0.6 2.0 -0.0 -0.3 0.8 -0.2 -1.4 -0.6 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.6 0.8 -1.8 1.9 1.5 0.0 -1.6 -0.3
Medication: Cholesterol lowering 1.2 1.8 7.5 -0.2 -0.5 0.3 0.7 2.7 -0.0 2.0
Depression (self-reported) 0.9 1.1 2.3 0.4 -1.2 1.5 1.5 0.1 -1.0 0.1
Medication: Lansoprazole 5.6 6.4 16.3 0.3 -2.0 4.0 3.8 1.5 -0.8 2.6
Prospective memory result 1.5 1.8 3.3 -1.4 1.8 -1.3 -1.3 -0.8 1.7 -0.4
Lung cancer (father) 0.5 0.6 1.4 -1.2 0.9 0.2 0.3 -0.8 0.9 0.3
Illnesses of mother 0.4 0.5 1.3 1.1 -0.7 -0.6 0.4 0.8 -0.8 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.2 0.2 0.1 -1.4 -1.5 -0.4 -0.4 -1.4
Pulse wave Arterial Stiffness index 1.4 1.7 4.2 -0.6 -0.5 2.0 2.0 0.4 0.3 1.7
Impedance of arm (left) 0.1 0.6 2.7 1.6 -0.2 -0.9 0.2 0.2 -0.6 -0.5
Arm fat mass (right) 0.3 1.2 2.2 -1.4 0.2 1.4 1.0 0.7 0.8 1.5
Trunk predicted mass 0.3 1.7 5.0 0.8 -1.1 -0.3 -0.4 -1.2 -1.8 -2.2
Standing height 1.0 10.0 29.4 3.3 -1.7 -2.2 -1.1 -2.6 -3.8 -5.4
Length of working week for main job 0.2 0.3 1.3 -1.1 0.2 0.1 -0.0 -0.7 0.2 -0.2
Exposure to tobacco smoke at home 0.5 0.6 1.0 0.9 -0.7 0.8 0.2 -1.0 -0.6 -0.9
Breastfed as a baby 1.1 1.4 2.9 0.9 -1.6 0.7 0.9 -0.8 -1.7 -1.2
Tense / ‘highly strung’ 0.7 1.1 1.6 -0.0 1.2 -1.3 -1.2 -1.2 0.5 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.6 0.5 -0.3 -0.8 0.1 0.4 -0.4
Hair/balding pattern: Pattern 4 0.3 0.7 2.9 0.3 0.1 -0.9 -1.7 0.2 -0.2 -0.9
Birth weight of first child 0.4 0.8 1.9 1.0 -0.9 0.8 1.4 0.3 -1.0 0.2
Peak expiratory flow (PEF) 0.8 1.8 4.4 -0.3 0.7 -1.2 -1.7 -1.7 0.2 -2.1
Pulse wave reflection index 0.6 0.8 3.7 -0.2 -0.5 1.1 1.9 -0.4 0.1 0.5
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.6 -1.0 0.8 -0.0 0.2 0.3 1.3 0.8
Loud music exposure frequency 0.4 0.4 1.2 -0.2 0.6 -1.1 -0.3 -0.6 0.2 -0.8
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.7 0.1 -0.1 -0.5 -0.0 -0.9 -0.3 -0.8
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 5.6 2.4 -1.6 0.6 0.2 0.8 -1.7 0.1
Blood clot in the leg (DVT) 0.9 1.1 3.0 -1.7 1.1 -0.3 -0.3 0.3 1.6 0.9
Medication: Paracetamol 0.1 0.2 0.5 -0.5 -0.5 0.7 0.3 0.3 -0.4 0.2
Headache pain in last month 0.4 0.7 3.1 -0.5 0.0 0.1 -0.4 1.8 0.4 0.9
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 6.1 0.5 0.2 -0.5 -1.0 -2.4 -0.5 -2.5
Glaucoma (self-reported) 0.5 0.5 1.1 1.1 -0.8 0.8 0.2 0.9 -0.4 0.5
Gout (self-reported) 0.3 0.4 0.9 0.1 -0.9 0.0 0.7 0.8 -1.0 0.2
Hypothyroidism/myxoedema (self-reported) 1.7 3.4 11.8 -0.3 0.1 1.3 1.6 2.5 1.3 3.4
Medication: Amlodipine 0.2 0.3 1.3 0.3 -0.4 0.2 1.2 0.5 -0.3 0.4
Medication: Ventolin 100micrograms inhaler 1.0 1.2 2.7 0.3 -1.2 1.6 0.6 -1.5 -1.2 -0.6
Birth weight 0.1 0.3 0.6 0.8 -0.2 -0.6 0.2 0.4 -0.7 -0.2
Chronic bronchitis/emphysema (mother) 2.6 3.1 5.4 -0.2 1.7 -2.3 -2.2 -1.6 0.9 -2.2
High blood pressure (siblings) 1.1 1.5 4.4 -0.0 -1.3 2.1 1.7 -0.5 -1.1 -0.1
Forced vital capacity (FVC), Best measure 0.4 1.5 4.1 0.5 -0.2 -1.3 -1.7 -1.0 -0.9 -2.0
Body fat percentage 0.4 1.6 3.8 -2.0 0.5 1.5 1.0 0.5 1.2 1.4
Leg fat percentage (right) 0.4 1.5 4.2 -2.0 0.7 1.1 0.5 0.6 1.4 1.4
Arm fat-free mass (right) 0.1 0.7 2.4 -0.5 -0.3 -0.2 -0.5 -1.0 -0.8 -1.5
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.1 -0.3 0.5 -0.4 -0.2 -0.4 0.2
Comparative body size at age 10 0.7 1.9 4.6 0.1 -1.5 2.1 2.0 0.5 -0.9 1.0
Number of full brothers 0.7 0.9 1.5 0.8 -1.0 0.0 1.0 -1.1 -1.2 -1.1
Worry too long after embarrassment 3.2 5.4 9.4 1.5 -3.1 2.7 2.7 1.7 -2.8 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.4 -0.8 0.7 -0.3 -0.5 1.1 1.0 1.2
Wheeze or whistling in the chest in last year 0.7 1.2 4.0 0.0 -0.2 0.7 -0.9 -2.0 -0.6 -1.7
Number of children fathered 0.3 0.4 1.6 -0.6 -0.0 1.3 -0.2 -0.7 0.2 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 7.1 -2.7 1.0 0.3 -1.4 -0.4 1.3 0.1
Age at first live birth 0.6 1.0 2.1 1.2 -0.7 0.1 1.4 -0.9 -1.1 -0.9
Pulse wave peak to peak time 2.0 2.3 5.3 0.8 0.4 -2.3 -2.2 -0.6 -0.6 -2.2
Health satisfaction 0.8 1.0 2.1 -1.4 1.1 -0.2 -0.2 -1.3 0.8 -1.1
Shortness of breath walking on level ground 0.6 0.7 2.9 0.0 -0.3 0.5 0.5 1.7 -0.4 1.2
Qualifications: College or University degree 2.0 6.3 12.2 2.9 -3.0 1.0 1.6 -2.1 -3.5 -2.5
Eye problems/disorders: None of the above 0.4 0.5 1.2 -0.3 0.6 -0.9 -0.7 -0.8 -0.0 -1.1
Mouth/teeth dental problems: Loose teeth 2.5 3.0 4.8 2.1 -2.1 2.2 1.9 -0.0 -1.8 0.6
Emphysema/chronic bronchitis 2.4 2.7 6.1 1.9 -1.9 1.1 2.5 0.9 -1.7 0.6
Medication for pain relief, constipation, heartburn 0.9 1.6 3.0 -0.2 1.1 -1.6 -1.5 -1.7 0.5 -1.5
Neck or shoulder pain in last month 1.2 1.6 3.3 -1.8 1.5 -0.4 -1.5 0.4 1.8 0.2
Medication: Blood pressure 1.4 2.4 7.9 -0.9 0.1 1.0 1.2 2.2 1.0 2.8
Angina (self-reported) 0.4 0.5 1.7 0.3 -0.5 -0.1 1.1 1.3 -0.6 0.3
Migraine (self-reported) 0.9 1.2 3.2 -1.1 0.6 0.6 0.3 1.0 1.3 1.8
Medication: Ibuprofen 1.8 2.2 5.5 0.5 -1.8 2.3 1.7 -1.1 -1.4 -0.7
Medication: Allopurinol 1.2 1.6 5.3 0.0 -0.7 0.5 1.2 2.3 -0.3 1.8
Medication: Omeprazole 0.4 0.5 1.7 -0.7 0.0 0.0 -0.6 -0.9 -0.4 -1.3
Medication: Seretide 50 evohaler 0.7 0.9 2.1 1.2 -0.3 -1.3 -0.5 1.5 -0.7 0.2
Mean time to correctly identify matches 0.3 0.6 2.4 0.8 -0.7 0.1 -0.3 1.5 -0.5 0.9
Heart disease (mother) 0.7 0.8 3.3 -0.3 -0.3 1.8 0.0 -1.4 0.1 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.9 0.7 -0.1 -0.9 -0.9 0.1 -0.5 -0.9
Whole body fat mass 0.1 0.6 1.5 -1.2 0.1 1.2 0.8 0.2 0.5 0.7
Leg fat mass (right) 0.2 0.8 2.1 -1.4 0.1 1.2 0.7 0.4 0.6 0.9
Arm predicted mass (right) 0.1 0.7 2.7 -0.2 -0.4 -0.2 -0.4 -0.9 -0.9 -1.6
Pulse rate, automated reading 0.2 0.7 2.3 -0.1 0.9 -1.1 -1.5 -0.1 0.6 -0.7
Alcohol intake frequency. 0.7 1.7 7.2 0.1 -0.1 -0.1 0.5 2.7 0.4 2.0
Comparative height size at age 10 1.6 8.7 30.9 1.8 -0.9 -2.3 -2.0 -2.8 -3.0 -5.6
Number of full sisters 2.4 3.0 5.0 -2.0 1.6 -1.0 -2.2 -2.0 1.3 -1.6
Suffer from ‘nerves’ 0.3 0.5 1.7 1.1 -0.3 -0.5 0.4 1.3 -0.6 0.4
Overall health rating 0.3 0.6 2.1 -0.1 -0.3 0.7 0.8 1.4 -0.3 0.9
Chest pain or discomfort 0.9 1.3 3.5 1.9 -1.2 0.3 1.2 0.3 -1.4 -0.7
Had major operations 1.6 1.8 3.8 1.2 -1.7 0.7 1.7 -0.2 -1.9 -1.0
Age at last live birth 0.6 0.9 3.2 0.5 -0.3 -0.7 0.5 -1.1 -0.8 -1.8
Family relationship satisfaction 1.1 1.3 3.9 0.0 -0.1 -0.4 -1.1 -1.8 -0.8 -2.0
Leg pain on walking 0.6 0.7 1.9 -1.4 0.7 0.1 -0.8 0.7 0.8 1.0
Qualifications: NVQ or HND or HNC or equivalent 2.8 3.4 5.2 -1.9 2.3 -2.0 -2.1 1.2 2.2 0.6
Commuting to job workplace: Car/motor vehicle 1.2 1.4 4.1 -2.0 1.3 -0.2 -0.2 -0.3 1.7 0.9
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.6 -0.8 1.3 -1.0 0.2 -0.0 1.3 1.1
Medication: Aspirin 1.8 2.3 3.8 1.5 -1.6 1.0 1.9 1.9 -1.1 1.4
Supplements: Vitamin C 1.1 1.3 4.7 2.2 -1.1 -0.4 0.3 0.4 -1.4 -0.8
Knee pain experienced in last month 0.3 0.5 1.3 -0.6 0.5 -0.5 -0.7 1.1 0.5 0.6
Hypertension (Self-reported) 1.2 3.3 6.3 0.2 -1.4 2.0 2.5 2.2 -0.6 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.2 -1.8 1.4 -0.1 -0.1 0.6 1.6 1.0
Illnesses of father: Heart disease 0.5 0.7 1.4 0.4 -1.0 1.2 0.5 0.7 -1.1 0.8
Illnesses of siblings: Diabetes 1.2 1.5 3.3 1.0 -1.8 1.3 1.3 0.2 -1.6 -0.3
Smoking status: Previous 1.6 2.4 4.1 0.6 -1.7 1.7 0.9 -1.6 -2.0 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 4.1 0.8 -0.7 -0.5 -1.2 -0.6 -1.5 -2.0
Whole body fat-free mass 0.2 0.9 2.7 0.4 -0.8 0.0 -0.1 -1.0 -1.4 -1.6
Leg fat-free mass (right) 0.1 0.3 0.7 0.1 -0.6 0.4 0.2 -0.5 -0.9 -0.8
Arm fat percentage (left) 0.6 2.3 5.3 -1.9 0.5 1.5 1.0 1.2 1.5 2.3
Average weekly red wine intake 2.7 4.0 12.0 1.2 -1.0 -0.4 -0.2 -3.1 -1.9 -3.5
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.8 0.3 -0.1 0.8 0.6 -1.4 -0.2 -0.6
Mood swings 1.4 2.5 6.4 -0.2 1.7 -2.5 -2.5 0.2 0.6 -1.2
Loneliness, isolation 1.1 1.5 3.9 1.6 -0.9 -0.0 -0.3 -0.9 -1.5 -2.0
Long-standing illness, disability or infirmity 1.2 1.8 6.9 -0.6 -0.5 1.0 0.4 2.6 -0.2 1.9
Ever had bowel cancer screening 0.3 0.4 1.1 0.5 0.1 -0.9 -0.6 -0.1 0.0 -1.0
Diabetes diagnosed by doctor 0.9 1.4 2.7 0.1 -1.6 1.4 0.9 -0.9 -1.6 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.4 0.2 -0.5 -0.3 -0.2 0.1 -0.5
Friendships satisfaction 0.4 0.5 1.6 0.3 -0.4 -0.2 0.3 -0.9 -0.9 -1.2
Qualifications: nursing, teaching 1.8 2.7 9.0 1.3 -1.1 -1.0 -1.1 -1.5 -1.7 -3.0
Commuting to job workplace: Walk 2.8 3.0 7.4 2.7 -1.9 -0.7 0.5 0.8 -2.6 -1.6
Eye problems/disorders: Cataract 0.4 0.5 1.4 1.1 -0.6 -0.1 0.0 1.2 -0.6 0.4
Mouth/teeth dental problems: Mouth ulcers 3.2 5.0 9.9 1.8 -3.1 2.7 2.5 0.8 -2.8 -0.1
Medication for cholesterol 0.1 0.2 0.9 0.9 -0.4 0.1 -0.0 0.0 -0.5 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 4.5 0.1 0.1 1.1 0.8 1.7 0.6 2.1
Back pain experienced in last month 0.5 0.8 1.3 -0.9 1.1 -1.0 -0.9 -0.5 1.0 -0.6
Mineral and other dietary supplements 1.6 2.2 4.8 -2.1 1.9 -0.7 -1.0 0.1 2.2 0.8
Breast cancer (self-reported) 0.5 0.6 1.2 -1.1 1.0 -0.2 -0.8 -1.0 0.6 -0.5
Asthma (self-reported) 0.2 0.4 1.3 -0.1 -0.2 0.4 -0.4 -1.1 -0.5 -0.7
Osteoporosis (self-reported) 2.2 2.8 7.5 1.4 -1.2 -0.2 0.6 -2.2 -1.8 -2.7
Osteoarthritis (self-reported) 1.5 2.0 8.4 0.3 -0.9 0.7 0.0 2.9 -0.4 2.0
Medication: Aspirin 2.7 3.6 7.0 1.9 -1.8 1.1 2.2 2.6 -1.2 1.9
Medication: Gliclazide 1.0 1.1 3.2 -0.4 -0.5 1.2 1.0 1.3 0.3 1.8
Illnesses of father: None of the above (group 1) 1.0 1.3 1.8 -0.9 1.2 -1.3 -1.2 -0.9 1.0 -1.3
Smoking status: Current 0.3 0.4 1.5 -0.3 -0.1 1.2 0.8 0.0 0.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.7 -0.9 0.3 0.2 -0.3 1.1 0.7 1.3
Whole body water mass 0.2 1.0 2.9 0.4 -0.9 0.1 -0.1 -1.1 -1.5 -1.7
Leg predicted mass (right) 0.1 0.3 0.8 0.1 -0.6 0.3 0.2 -0.5 -0.9 -0.8
Arm fat mass (left) 0.2 1.0 2.1 -1.4 0.1 1.2 0.8 0.7 0.7 1.3
Number of self-reported non-cancer illnesses 1.7 3.0 4.8 0.7 -2.2 2.0 2.1 1.6 -1.8 1.0
Average weekly champagne plus white wine intake 0.5 0.6 1.3 1.1 -1.1 0.7 0.2 0.5 -1.0 0.4
Miserableness 0.2 0.4 1.0 1.0 -0.3 -0.2 0.1 0.9 -0.8 -0.5
Guilty feelings 1.3 2.0 4.5 2.1 -1.6 0.6 1.1 -0.0 -2.1 -0.8
Wears glasses or contact lenses 0.2 0.3 0.6 0.2 -0.3 -0.7 0.5 0.1 -0.6 -0.8
Ever taken oral contraceptive pill 1.5 1.6 4.2 0.8 -1.6 1.5 0.7 -0.3 -2.0 -1.1
Hearing aid user 1.6 1.8 5.3 0.1 -0.4 1.2 1.0 2.3 0.2 2.2
Mother’s age at death 0.9 1.1 2.8 1.7 -1.3 0.4 1.1 -0.4 -1.4 -0.5
Financial situation satisfaction 0.1 0.1 0.4 -0.7 0.3 0.1 0.1 -0.1 0.3 -0.3
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.7 -0.5 0.5 0.3 0.3 1.6 0.7 1.4
Commuting to job workplace: Public transport 0.8 1.0 3.2 0.1 -0.5 0.0 -0.8 -1.4 -0.9 -1.8
Eye problems/disorders: Glaucoma 0.4 0.4 1.7 0.4 0.0 0.3 -0.2 1.3 0.4 0.9
Medication: Blood pressure 0.2 0.4 0.7 -0.5 0.2 0.2 0.8 0.8 0.3 0.9
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.8 -0.6 0.6 -0.2 -1.4 0.9 0.8 0.3
Supplements: Fish oil (including cod liver oil) 2.2 2.9 6.2 2.2 -2.3 1.2 1.3 0.4 -2.5 -0.6
High cholesterol (Self-reported) 0.0 0.1 0.2 -0.3 -0.3 0.0 -0.0 0.4 -0.3 -0.2
Medication: Bendroflumethiazide 1.1 1.7 2.8 -1.6 1.4 -0.7 -0.3 1.3 1.6 1.7
Medication: Paracetamol 0.5 0.7 2.2 -0.8 -0.4 1.5 0.6 0.5 -0.1 1.2
Medication: Lisinopril 0.5 0.6 1.3 -0.2 0.7 -0.4 0.2 1.1 0.9 1.1
Medication: Atorvastatin 0.6 0.8 1.3 -1.2 0.7 -0.9 -1.2 0.8 0.7 -0.3
Illnesses of father: High blood pressure 0.6 0.7 1.7 -0.0 -0.7 1.3 1.2 0.4 -0.2 1.0
Alcohol drinker status: Never 0.8 0.9 3.1 -0.2 0.4 -0.8 -0.9 1.8 0.8 1.1
Ever smoked 1.0 1.7 6.4 -1.0 0.0 0.8 -0.2 -2.5 -0.3 -2.0
Basal metabolic rate 0.1 0.6 1.8 0.1 -0.7 0.3 -0.1 -0.9 -1.1 -1.3
Leg fat percentage (left) 0.4 1.6 5.2 -2.3 1.1 0.9 0.4 0.4 1.6 1.2
Arm fat-free mass (left) 0.1 0.6 1.5 0.1 -0.8 0.3 0.0 -0.6 -1.2 -1.2
Number of operations (self-reported) 0.5 0.8 2.1 0.7 -1.2 -0.3 0.7 0.6 -1.5 -0.5
Average weekly beer plus cider intake 4.8 6.9 10.4 -2.5 3.2 -2.2 -2.5 2.3 3.2 2.2
Irritability 0.2 0.4 1.3 0.5 0.5 -0.6 -0.6 -0.5 0.0 -1.2
Risk taking 1.2 1.8 5.6 -1.9 0.8 0.4 -0.7 -2.4 0.7 -1.2
Ever had prostate specific antigen (PSA) test 1.8 2.1 5.4 -1.3 1.5 -1.4 -2.3 -0.0 1.8 -0.1
Fractured/broken bones in last 5 years 0.4 0.5 1.4 -0.5 -0.2 0.8 1.1 -1.2 -0.5 -0.2
Age started oral contraceptive pill 1.1 1.4 3.8 0.6 0.3 -1.9 -0.7 -1.0 -0.7 -1.8
Diastolic blood pressure, automated reading 0.2 0.7 1.8 -1.4 0.9 -0.5 -1.0 0.1 1.0 0.2
Ever depressed for a whole week 0.2 0.3 1.1 -0.0 0.2 0.1 -0.1 1.0 0.5 0.7
Unable to work because of sickness or disability 1.6 2.1 3.8 1.2 -2.0 0.8 1.7 1.4 -1.9 -0.1
Commuting to job workplace: Cycle 2.2 2.6 6.1 2.5 -1.6 -0.3 0.6 -1.2 -2.3 -1.5
Myopia 1.1 1.6 4.5 2.1 -1.5 0.6 0.9 0.0 -1.8 -0.3
Vascular/heart problems diagnosed by doctor 0.7 1.9 4.7 0.4 0.5 -1.1 -1.8 -2.0 -0.2 -2.2
Cholesterol lowering medication 0.4 0.6 1.8 0.7 -1.0 0.2 -0.5 0.7 -1.3 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.7 -1.0 0.3 -0.3 -0.6 -1.1 -0.1 -1.3
Pain experienced in last month 1.6 2.7 6.5 2.5 -2.0 0.6 1.7 0.2 -2.2 0.1
Supplements: Calcium 1.9 2.1 4.5 1.8 -2.1 1.0 1.3 0.3 -2.0 -0.3
Basal cell carcinoma (self-reported) 1.0 1.2 3.3 0.6 0.6 -1.4 -0.7 -1.3 -0.1 -1.8
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.6 -1.2 0.8 -0.9 -0.7 0.7 0.8 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 3.3 -1.8 1.2 -0.4 -0.4 0.1 1.6 0.7
Heart disease (siblings) 0.5 0.6 0.8 -0.7 0.8 -0.8 -0.9 -0.6 0.8 -0.6
Alcohol drinker status: Previous 1.4 1.6 4.7 0.5 -1.4 1.7 2.2 -0.1 -1.0 0.8
Pack years of smoking 1.2 1.8 3.9 -1.1 1.5 0.0 -0.4 1.1 2.0 1.9
Impedance of whole body 0.2 0.9 2.6 1.6 -0.2 -1.0 -0.1 -0.3 -0.8 -1.3
Leg fat mass (left) 0.2 0.7 2.3 -1.5 0.3 1.0 0.5 0.2 0.7 0.7
Arm predicted mass (left) 0.1 0.6 1.7 -0.1 -0.7 0.4 0.1 -0.8 -1.1 -1.3