TWAS hub - PTPLAD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1300	0.0580	4.2e-04	0.100	NA	0.081	NA	0.026	7.5e-06	NA	5.5e-05	NA	1.6e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.1760	0.0540	1.5e-05	0.179	NA	0.147	NA	0.048	1.8e-06	NA	1.7e-05	NA	1.1e-02
3	GTEx	Nerve Tibial	0.0851	0.0375	1.3e-03	0.020	NA	0.022	NA	0.028	1.4e-02	NA	9.9e-03	NA	4.4e-03
4	METSIM	Adipose	0.0594	0.0238	2.9e-05	0.021	0.029	0.016	0.03	0.022	3.6e-04	2.7e-05	1.8e-03	2e-05	2.8e-04
5	TCGA	Breast Invasive Carcinoma	0.0353	0.0197	2.2e-05	0.024	0.016	0.022	NA	0.021	8.1e-06	2.8e-04	2.3e-05	NA	2.8e-05
6	TCGA	Cervical Squamous Cell Carcinoma	0.0880	0.0510	1.5e-03	0.058	0.062	0.044	NA	0.053	7.8e-04	5.2e-04	3.0e-03	NA	1.3e-03
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0536	0.0373	4.8e-03	0.011	0.013	0.017	NA	0.009	1.6e-02	1.1e-02	4.3e-03	NA	2.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Red Count	11.4	110.0	222.0	11.9	-14.1	9.2	9.9	-1.7	-14.9	-4.6
Medication: Lansoprazole	5.6	6.4	16.3	0.3	-2.0	4.0	3.8	1.5	-0.8	2.6
Heel T-Score	5.1	40.2	93.7	-8.4	7.9	-2.3	-3.5	1.5	9.7	5.9
Average weekly beer plus cider intake	4.8	6.9	10.4	-2.5	3.2	-2.2	-2.5	2.3	3.2	2.2
Vitamin and mineral supplements	3.3	4.5	11.3	-3.4	2.5	-1.1	-2.0	-1.8	2.2	-0.9
Mouth/teeth dental problems	3.3	5.0	8.8	-3.0	2.7	-1.1	-1.8	-2.6	2.7	-0.9
Worry too long after embarrassment	3.2	5.4	9.4	1.5	-3.1	2.7	2.7	1.7	-2.8	1.0
Mouth/teeth dental problems: Mouth ulcers	3.2	5.0	9.9	1.8	-3.1	2.7	2.5	0.8	-2.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	3.1	7.0	16.7	-3.3	3.4	-1.1	-1.6	0.8	4.1	2.3
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.4	5.2	-1.9	2.3	-2.0	-2.1	1.2	2.2	0.6
Commuting to job workplace: Walk	2.8	3.0	7.4	2.7	-1.9	-0.7	0.5	0.8	-2.6	-1.6
Diabetes (father)	2.7	3.4	6.2	2.0	-2.4	1.0	2.0	1.6	-2.5	0.4
Multivitamins +/- minerals	2.7	3.5	6.7	2.6	-2.4	1.6	1.9	0.9	-2.2	0.3
Average weekly red wine intake	2.7	4.0	12.0	1.2	-1.0	-0.4	-0.2	-3.1	-1.9	-3.5
Medication: Aspirin	2.7	3.6	7.0	1.9	-1.8	1.1	2.2	2.6	-1.2	1.9
Alcohol intake versus 10 years previously	2.6	3.8	6.2	-2.1	2.5	-2.2	-2.3	0.2	2.3	0.6
Chronic bronchitis/emphysema (mother)	2.6	3.1	5.4	-0.2	1.7	-2.3	-2.2	-1.6	0.9	-2.2
Mouth/teeth dental problems: Loose teeth	2.5	3.0	4.8	2.1	-2.1	2.2	1.9	-0.0	-1.8	0.6
Sensitivity / hurt feelings	2.4	4.2	7.6	-1.6	2.6	-2.0	-1.8	1.8	2.8	1.4
Emphysema/chronic bronchitis	2.4	2.7	6.1	1.9	-1.9	1.1	2.5	0.9	-1.7	0.6
Number of full sisters	2.4	3.0	5.0	-2.0	1.6	-1.0	-2.2	-2.0	1.3	-1.6
Osteoporosis (self-reported)	2.2	2.8	7.5	1.4	-1.2	-0.2	0.6	-2.2	-1.8	-2.7
Supplements: Fish oil (including cod liver oil)	2.2	2.9	6.2	2.2	-2.3	1.2	1.3	0.4	-2.5	-0.6
Commuting to job workplace: Cycle	2.2	2.6	6.1	2.5	-1.6	-0.3	0.6	-1.2	-2.3	-1.5
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	4.8	0.3	-1.8	2.2	2.0	1.6	-1.5	1.6
Pulse wave peak to peak time	2.0	2.3	5.3	0.8	0.4	-2.3	-2.2	-0.6	-0.6	-2.2
Qualifications: College or University degree	2.0	6.3	12.2	2.9	-3.0	1.0	1.6	-2.1	-3.5	-2.5
Supplements: Calcium	1.9	2.1	4.5	1.8	-2.1	1.0	1.3	0.3	-2.0	-0.3
Number of treatments/medications taken	1.8	3.2	5.9	0.6	-1.9	2.4	2.3	1.7	-1.2	1.4
Medication: Ibuprofen	1.8	2.2	5.5	0.5	-1.8	2.3	1.7	-1.1	-1.4	-0.7
Medication: Aspirin	1.8	2.3	3.8	1.5	-1.6	1.0	1.9	1.9	-1.1	1.4
Qualifications: nursing, teaching	1.8	2.7	9.0	1.3	-1.1	-1.0	-1.1	-1.5	-1.7	-3.0
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.4	-1.3	1.5	-1.4	-2.3	-0.0	1.8	-0.1
HDL Cholesterol	1.7	2.9	5.0	1.7	-2.1	1.7	1.1	-1.3	-2.2	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	10.0	-2.5	2.6	-0.4	-0.5	0.3	3.2	1.9
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	11.8	-0.3	0.1	1.3	1.6	2.5	1.3	3.4
Number of self-reported non-cancer illnesses	1.7	3.0	4.8	0.7	-2.2	2.0	2.1	1.6	-1.8	1.0
Supplements: Zinc	1.6	1.7	2.9	0.6	-1.0	1.6	1.7	1.6	-0.4	1.7
Comparative height size at age 10	1.6	8.7	30.9	1.8	-0.9	-2.3	-2.0	-2.8	-3.0	-5.6
Had major operations	1.6	1.8	3.8	1.2	-1.7	0.7	1.7	-0.2	-1.9	-1.0
Smoking status: Previous	1.6	2.4	4.1	0.6	-1.7	1.7	0.9	-1.6	-2.0	-1.8
Mineral and other dietary supplements	1.6	2.2	4.8	-2.1	1.9	-0.7	-1.0	0.1	2.2	0.8
Hearing aid user	1.6	1.8	5.3	0.1	-0.4	1.2	1.0	2.3	0.2	2.2
Unable to work because of sickness or disability	1.6	2.1	3.8	1.2	-2.0	0.8	1.7	1.4	-1.9	-0.1
Pain experienced in last month	1.6	2.7	6.5	2.5	-2.0	0.6	1.7	0.2	-2.2	0.1
Major Depression (MDD)	1.5	1.8	3.9	-2.0	0.8	0.9	-0.0	1.6	1.3	1.7
Prospective memory result	1.5	1.8	3.3	-1.4	1.8	-1.3	-1.3	-0.8	1.7	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	7.1	-2.7	1.0	0.3	-1.4	-0.4	1.3	0.1
Osteoarthritis (self-reported)	1.5	2.0	8.4	0.3	-0.9	0.7	0.0	2.9	-0.4	2.0
Ever taken oral contraceptive pill	1.5	1.6	4.2	0.8	-1.6	1.5	0.7	-0.3	-2.0	-1.1
Age at First Birth	1.4	2.1	3.6	1.8	-1.9	0.6	1.6	0.9	-1.9	0.3
Blood Eosinophil Count	1.4	10.5	19.4	-3.4	4.4	-3.3	-3.8	-0.1	4.2	-0.2
Hypothyroidism (self reported)	1.4	3.2	11.2	-0.2	-0.1	1.2	1.3	2.5	1.1	3.3
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.6	0.8	-1.8	1.9	1.5	0.0	-1.6	-0.3
Pulse wave Arterial Stiffness index	1.4	1.7	4.2	-0.6	-0.5	2.0	2.0	0.4	0.3	1.7
Medication: Blood pressure	1.4	2.4	7.9	-0.9	0.1	1.0	1.2	2.2	1.0	2.8
Mood swings	1.4	2.5	6.4	-0.2	1.7	-2.5	-2.5	0.2	0.6	-1.2
Alcohol drinker status: Previous	1.4	1.6	4.7	0.5	-1.4	1.7	2.2	-0.1	-1.0	0.8
Intelligence (Savage-Jansen 2018)	1.3	4.1	10.7	3.0	-2.3	0.0	0.7	-0.3	-3.3	-1.7
Bipolar Disorder (2011)	1.3	1.3	3.8	0.3	-0.6	1.3	0.7	1.5	0.1	2.0
Smoking Status	1.3	3.2	8.5	0.5	-2.0	2.9	2.4	-0.8	-1.8	-0.4
High blood pressure (mother)	1.3	1.9	4.5	-2.1	1.3	0.8	-0.2	0.7	1.9	1.5
Father’s age at death	1.3	1.7	3.9	1.0	-2.0	1.3	1.2	-0.3	-1.9	-0.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.6	2.4	-1.6	0.6	0.2	0.8	-1.7	0.1
Guilty feelings	1.3	2.0	4.5	2.1	-1.6	0.6	1.1	-0.0	-2.1	-0.8
Bipolar Disorder (2018)	1.2	1.9	5.6	1.6	-0.3	-0.1	0.6	2.4	0.2	2.1
Body Mass Index (BMI) (2010)	1.2	1.6	3.8	-1.1	1.0	-0.3	-0.2	1.4	1.8	1.9
Taking other prescription medications	1.2	1.8	5.1	0.2	-1.6	2.3	1.8	0.7	-1.1	0.6
High blood pressure	1.2	3.2	6.5	0.2	-1.3	1.9	2.2	2.4	-0.4	2.5
Medication: Levothyroxine sodium	1.2	2.0	4.1	1.0	-1.0	1.1	1.6	2.0	-0.4	2.0
Had menopause	1.2	1.5	3.6	1.2	-1.2	-0.2	0.5	-0.9	-1.7	-1.9
Qualifications: A levels/AS levels or equivalent	1.2	2.8	8.4	1.0	-0.6	-1.1	-0.6	-2.5	-1.3	-2.9
Medication: Cholesterol lowering	1.2	1.8	7.5	-0.2	-0.5	0.3	0.7	2.7	-0.0	2.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.1	0.5	0.2	-0.5	-1.0	-2.4	-0.5	-2.5
Neck or shoulder pain in last month	1.2	1.6	3.3	-1.8	1.5	-0.4	-1.5	0.4	1.8	0.2
Medication: Allopurinol	1.2	1.6	5.3	0.0	-0.7	0.5	1.2	2.3	-0.3	1.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.1	-2.0	1.3	-0.2	-0.2	-0.3	1.7	0.9
Hypertension (Self-reported)	1.2	3.3	6.3	0.2	-1.4	2.0	2.5	2.2	-0.6	2.4
Illnesses of siblings: Diabetes	1.2	1.5	3.3	1.0	-1.8	1.3	1.3	0.2	-1.6	-0.3
Long-standing illness, disability or infirmity	1.2	1.8	6.9	-0.6	-0.5	1.0	0.4	2.6	-0.2	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.5	0.1	0.1	1.1	0.8	1.7	0.6	2.1
Risk taking	1.2	1.8	5.6	-1.9	0.8	0.4	-0.7	-2.4	0.7	-1.2
Pack years of smoking	1.2	1.8	3.9	-1.1	1.5	0.0	-0.4	1.1	2.0	1.9
Crohns Disease (2012)	1.1	1.8	4.5	0.6	-0.8	1.9	2.1	0.9	-0.0	1.7
Fasting Glucose	1.1	1.3	2.5	0.7	-1.5	1.4	1.6	0.3	-1.4	-0.0
Medication for hormone replacement therapy	1.1	1.2	2.4	-1.6	1.2	-0.5	-0.7	-1.6	1.2	-0.6
Medication: Metformin	1.1	1.5	3.5	0.7	-1.9	1.6	1.4	0.1	-1.4	0.2
Financial difficulties in last 2 years	1.1	1.4	3.4	1.7	-1.5	0.0	-0.2	0.3	-1.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.2	-0.8	0.3	-0.3	-0.6	-1.8	-0.4	-2.0
Breastfed as a baby	1.1	1.4	2.9	0.9	-1.6	0.7	0.9	-0.8	-1.7	-1.2
High blood pressure (siblings)	1.1	1.5	4.4	-0.0	-1.3	2.1	1.7	-0.5	-1.1	-0.1
Family relationship satisfaction	1.1	1.3	3.9	0.0	-0.1	-0.4	-1.1	-1.8	-0.8	-2.0
Supplements: Vitamin C	1.1	1.3	4.7	2.2	-1.1	-0.4	0.3	0.4	-1.4	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.2	-1.8	1.4	-0.1	-0.1	0.6	1.6	1.0
Loneliness, isolation	1.1	1.5	3.9	1.6	-0.9	-0.0	-0.3	-0.9	-1.5	-2.0
Medication: Bendroflumethiazide	1.1	1.7	2.8	-1.6	1.4	-0.7	-0.3	1.3	1.6	1.7
Age started oral contraceptive pill	1.1	1.4	3.8	0.6	0.3	-1.9	-0.7	-1.0	-0.7	-1.8
Myopia	1.1	1.6	4.5	2.1	-1.5	0.6	0.9	0.0	-1.8	-0.3
HbA1C	1.0	1.2	1.8	1.3	-1.3	0.5	1.3	0.8	-1.4	0.4
Lupus	1.0	1.5	3.9	0.6	-1.5	1.3	2.0	-0.3	-1.4	0.1
Medication: Co-codamol	1.0	1.2	1.9	0.9	-1.2	0.9	1.1	-0.5	-1.4	-1.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.0	1.4	-1.4	1.4	1.2	0.5	-1.1	0.2
Number of incorrect matches in round	1.0	1.6	3.0	0.6	-1.7	1.7	1.5	0.2	-1.7	-0.3
Past tobacco smoking	1.0	1.8	3.5	-0.3	1.4	-1.9	-1.1	1.4	1.5	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.0	-0.2	1.1	-1.7	-1.2	-1.3	0.5	-1.4
Medication: Simvastatin	1.0	1.5	2.2	0.6	-1.4	1.1	1.4	1.5	-1.0	1.2
Standing height	1.0	10.0	29.4	3.3	-1.7	-2.2	-1.1	-2.6	-3.8	-5.4
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.7	0.3	-1.2	1.6	0.6	-1.5	-1.2	-0.6
Medication: Gliclazide	1.0	1.1	3.2	-0.4	-0.5	1.2	1.0	1.3	0.3	1.8
Illnesses of father: None of the above (group 1)	1.0	1.3	1.8	-0.9	1.2	-1.3	-1.2	-0.9	1.0	-1.3
Ever smoked	1.0	1.7	6.4	-1.0	0.0	0.8	-0.2	-2.5	-0.3	-2.0
Basal cell carcinoma (self-reported)	1.0	1.2	3.3	0.6	0.6	-1.4	-0.7	-1.3	-0.1	-1.8
Alzheimer’s Disease (in mother)	0.9	1.0	3.8	2.0	-0.6	-0.5	0.7	-0.3	-1.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.5	2.3	-1.0	-1.0	0.0	-1.0	-1.8	-2.0
Height	0.9	16.6	44.1	3.8	-3.1	-1.6	-1.3	-3.2	-5.8	-6.6
Cardiovascular Disease	0.9	2.9	7.0	-0.5	-0.9	1.7	1.9	2.4	0.3	2.7
Hearing difficulty/problems: Yes	0.9	1.3	6.5	-0.3	0.3	-0.9	-0.7	2.5	0.2	1.2
Townsend deprivation index at recruitment	0.9	1.3	3.4	0.2	-0.5	1.2	1.5	1.2	-0.2	1.9
Qualifications: CSEs or equivalent	0.9	1.2	1.7	-0.5	1.1	-1.0	-1.0	1.2	1.3	1.2
Serious illness, injury or assault to yourself	0.9	1.1	3.1	-1.8	1.0	0.2	-1.5	0.2	1.1	0.1
Depression (self-reported)	0.9	1.1	2.3	0.4	-1.2	1.5	1.5	0.1	-1.0	0.1
Blood clot in the leg (DVT)	0.9	1.1	3.0	-1.7	1.1	-0.3	-0.3	0.3	1.6	0.9
Medication for pain relief, constipation, heartburn	0.9	1.6	3.0	-0.2	1.1	-1.6	-1.5	-1.7	0.5	-1.5
Migraine (self-reported)	0.9	1.2	3.2	-1.1	0.6	0.6	0.3	1.0	1.3	1.8
Chest pain or discomfort	0.9	1.3	3.5	1.9	-1.2	0.3	1.2	0.3	-1.4	-0.7
Diabetes diagnosed by doctor	0.9	1.4	2.7	0.1	-1.6	1.4	0.9	-0.9	-1.6	-1.1
Mother’s age at death	0.9	1.1	2.8	1.7	-1.3	0.4	1.1	-0.4	-1.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.3	-1.8	1.2	-0.4	-0.4	0.1	1.6	0.7
Irritable Bowel Disease (IBD)	0.8	2.0	3.9	1.2	-0.8	0.9	1.9	2.0	-0.5	1.7
Ulcerative Colitis (UC)	0.8	1.5	2.4	1.5	-1.3	0.6	1.3	1.4	-1.4	0.7
Prostate Cancer	0.8	1.1	2.3	-1.0	1.2	-0.8	-1.5	0.4	1.4	0.5
Coronary Artery Disease (CAD)	0.8	1.0	3.6	1.3	-0.4	0.2	0.1	1.9	-0.2	1.1
Mean Putamen Volume	0.8	0.9	2.1	-0.6	1.0	-0.2	0.0	1.0	1.3	1.5
Hand grip strength (left)	0.8	2.1	8.5	0.4	0.1	-0.5	-0.1	-2.4	-0.6	-2.9
Systolic blood pressure, automated reading	0.8	2.3	4.1	-1.5	2.0	-1.6	-1.7	-0.7	1.9	-0.5
Pack years adult smoking proportion	0.8	1.2	2.9	-1.0	1.1	0.3	-0.1	1.0	1.6	1.7
Hand grip strength (right)	0.8	2.1	8.4	0.7	-0.7	-0.6	0.1	-1.8	-1.4	-2.9
Relative age voice broke	0.8	1.2	3.2	0.5	-1.2	1.4	1.8	-0.4	-1.0	-0.1
Age when periods started (menarche)	0.8	1.8	5.8	-0.9	1.6	0.1	0.2	0.3	2.4	1.9
Sitting height	0.8	5.7	14.7	0.8	0.7	-3.2	-3.0	-2.0	-1.1	-3.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.8	-1.2	0.5	0.8	1.7	0.0	0.9	1.1
Diabetes (self-reported)	0.8	1.2	2.1	0.1	-1.5	1.4	1.2	-0.7	-1.4	-0.9
Medication: Ramipril	0.8	1.1	3.0	-0.6	-0.1	0.3	0.9	1.7	0.5	1.7
Happiness	0.8	0.9	1.4	-0.9	1.2	-1.1	-0.7	-0.9	0.7	-1.1
Peak expiratory flow (PEF)	0.8	1.8	4.4	-0.3	0.7	-1.2	-1.7	-1.7	0.2	-2.1
Health satisfaction	0.8	1.0	2.1	-1.4	1.1	-0.2	-0.2	-1.3	0.8	-1.1
Commuting to job workplace: Public transport	0.8	1.0	3.2	0.1	-0.5	0.0	-0.8	-1.4	-0.9	-1.8
Alcohol drinker status: Never	0.8	0.9	3.1	-0.2	0.4	-0.8	-0.9	1.8	0.8	1.1
BMI	0.7	4.1	11.2	-1.4	-0.9	3.3	2.4	1.0	0.5	2.8
Stomach or abdominal pain in last month	0.7	0.9	2.6	-0.2	-0.8	1.5	1.6	0.2	-0.5	0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	-0.0	-0.1	1.4	1.3	0.2	0.5	1.4
Body mass index (BMI)	0.7	2.8	5.8	-2.4	0.4	2.0	1.1	0.9	1.5	2.3
Alcohol usually taken with meals	0.7	1.2	3.2	1.2	-0.4	-0.2	-0.4	-1.8	-0.8	-1.7
Tense / ‘highly strung’	0.7	1.1	1.6	-0.0	1.2	-1.3	-1.2	-1.2	0.5	-1.1
Comparative body size at age 10	0.7	1.9	4.6	0.1	-1.5	2.1	2.0	0.5	-0.9	1.0
Number of full brothers	0.7	0.9	1.5	0.8	-1.0	0.0	1.0	-1.1	-1.2	-1.1
Wheeze or whistling in the chest in last year	0.7	1.2	4.0	0.0	-0.2	0.7	-0.9	-2.0	-0.6	-1.7
Medication: Seretide 50 evohaler	0.7	0.9	2.1	1.2	-0.3	-1.3	-0.5	1.5	-0.7	0.2
Heart disease (mother)	0.7	0.8	3.3	-0.3	-0.3	1.8	0.0	-1.4	0.1	-0.4
Alcohol intake frequency.	0.7	1.7	7.2	0.1	-0.1	-0.1	0.5	2.7	0.4	2.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.6	-0.8	1.3	-1.0	0.2	-0.0	1.3	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.7	-0.5	0.5	0.3	0.3	1.6	0.7	1.4
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.7	0.4	0.5	-1.1	-1.8	-2.0	-0.2	-2.2
Ovarian Cancer	0.6	0.8	3.3	0.9	-0.4	0.1	0.4	1.8	-0.3	1.0
Neuroticism (2016)	0.6	0.9	2.0	1.4	-0.6	0.4	1.3	1.0	-1.1	0.3
Systolic Blood Pressure	0.6	3.2	7.3	-1.9	2.2	-1.1	-1.6	1.0	2.7	1.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.9	0.6	-0.5	0.0	0.5	2.0	-0.6	0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	1.1	-0.6	-0.8	0.1	0.0	-1.1	-1.1
Diabetes (mother)	0.6	0.7	3.1	-0.6	0.3	-0.3	-1.8	-0.8	0.1	-0.9
Heart attack	0.6	0.8	1.7	-1.3	0.9	-1.0	-0.8	0.7	0.9	-0.0
Fluid intelligence score	0.6	1.3	2.4	1.5	-0.6	-1.3	-0.8	-0.6	-1.3	-1.4
Arm fat percentage (right)	0.6	2.4	5.7	-1.8	0.4	1.8	1.2	1.1	1.4	2.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.1	1.3	-1.0	0.0	-0.3	0.9	-1.4	-1.2
Pulse wave reflection index	0.6	0.8	3.7	-0.2	-0.5	1.1	1.9	-0.4	0.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	-0.8	0.7	-0.3	-0.5	1.1	1.0	1.2
Age at first live birth	0.6	1.0	2.1	1.2	-0.7	0.1	1.4	-0.9	-1.1	-0.9
Shortness of breath walking on level ground	0.6	0.7	2.9	0.0	-0.3	0.5	0.5	1.7	-0.4	1.2
Age at last live birth	0.6	0.9	3.2	0.5	-0.3	-0.7	0.5	-1.1	-0.8	-1.8
Leg pain on walking	0.6	0.7	1.9	-1.4	0.7	0.1	-0.8	0.7	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.1	0.8	-0.7	-0.5	-1.2	-0.6	-1.5	-2.0
Arm fat percentage (left)	0.6	2.3	5.3	-1.9	0.5	1.5	1.0	1.2	1.5	2.3
Medication: Atorvastatin	0.6	0.8	1.3	-1.2	0.7	-0.9	-1.2	0.8	0.7	-0.3
Illnesses of father: High blood pressure	0.6	0.7	1.7	-0.0	-0.7	1.3	1.2	0.4	-0.2	1.0
Bipolar Disorder or Schizophrenia	0.5	1.1	5.4	0.6	-0.1	-0.3	-0.1	2.3	0.2	1.5
Crohns Disease (2017)	0.5	1.2	2.9	0.1	0.1	0.8	1.5	1.3	0.8	1.7
Breast Cancer	0.5	1.3	3.3	0.9	-0.9	0.2	0.0	-1.2	-1.5	-1.8
Triglycerides	0.5	0.9	3.1	0.8	-1.0	0.2	-0.1	1.8	-0.9	0.8
Blood Platelet Count	0.5	5.3	15.4	-1.2	2.0	-3.4	-3.9	1.7	1.5	-0.2
Waist Hip Ratio (WHR)	0.5	2.0	4.2	-2.0	1.5	-1.5	-1.1	-1.4	0.8	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.9	0.2	-1.7	1.2	0.7	0.5	-1.3	-0.1
Lung FEV1/FVC ratio	0.5	2.7	7.0	-0.8	1.2	-0.9	-0.3	2.6	1.7	2.5
Average weekly spirits intake	0.5	0.6	1.9	-0.5	1.0	-0.8	-0.6	0.3	1.4	0.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.3	0.6	-0.9	0.7	0.2	-0.8	-1.1	-1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.6	0.2	0.3	-1.3	-0.9	-0.3	-0.3	-1.2
Impedance of leg (left)	0.5	2.3	6.0	0.6	1.0	-2.1	-1.6	-1.4	-0.1	-2.4
Had other major operations	0.5	0.6	1.3	-0.1	0.3	-1.0	-0.8	1.1	0.6	0.9
Qualifications: None of the above	0.5	1.0	3.1	-0.6	0.1	0.4	0.9	1.4	0.6	1.8
Number of live births	0.5	0.7	1.8	0.9	-1.4	0.5	0.3	0.7	-1.3	-0.3
Noisy workplace	0.5	0.6	2.1	-1.4	0.7	0.8	0.1	-0.1	1.0	0.5
Lung cancer (father)	0.5	0.6	1.4	-1.2	0.9	0.2	0.3	-0.8	0.9	0.3
Exposure to tobacco smoke at home	0.5	0.6	1.0	0.9	-0.7	0.8	0.2	-1.0	-0.6	-0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-1.0	0.8	-0.0	0.2	0.3	1.3	0.8
Glaucoma (self-reported)	0.5	0.5	1.1	1.1	-0.8	0.8	0.2	0.9	-0.4	0.5
Illnesses of father: Heart disease	0.5	0.7	1.4	0.4	-1.0	1.2	0.5	0.7	-1.1	0.8
Back pain experienced in last month	0.5	0.8	1.3	-0.9	1.1	-1.0	-0.9	-0.5	1.0	-0.6
Breast cancer (self-reported)	0.5	0.6	1.2	-1.1	1.0	-0.2	-0.8	-1.0	0.6	-0.5
Average weekly champagne plus white wine intake	0.5	0.6	1.3	1.1	-1.1	0.7	0.2	0.5	-1.0	0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	-0.6	0.6	-0.2	-1.4	0.9	0.8	0.3
Medication: Paracetamol	0.5	0.7	2.2	-0.8	-0.4	1.5	0.6	0.5	-0.1	1.2
Medication: Lisinopril	0.5	0.6	1.3	-0.2	0.7	-0.4	0.2	1.1	0.9	1.1
Number of operations (self-reported)	0.5	0.8	2.1	0.7	-1.2	-0.3	0.7	0.6	-1.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	-1.0	0.3	-0.3	-0.6	-1.1	-0.1	-1.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.6	-1.2	0.8	-0.9	-0.7	0.7	0.8	-0.0
Heart disease (siblings)	0.5	0.6	0.8	-0.7	0.8	-0.8	-0.9	-0.6	0.8	-0.6
Alzheimer’s Disease (in father)	0.4	0.4	0.8	-0.4	0.7	-0.9	-0.0	0.8	0.8	0.5
Rheumatoid Arthritis	0.4	0.6	1.5	-0.4	1.0	-0.8	-1.2	-0.2	0.8	-0.4
Blood White Count	0.4	3.0	12.9	1.8	-1.5	-0.4	-0.3	3.6	-1.3	0.8
Tanning	0.4	4.3	11.6	-0.1	-0.9	3.0	2.4	1.6	0.4	3.4
Relative age of first facial hair	0.4	0.9	2.0	1.0	-1.1	0.4	1.4	0.6	-1.2	0.1
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	-0.0	0.4	-1.1	-1.0	0.0	-0.2	-0.7
Trunk fat percentage	0.4	1.5	3.2	-1.8	0.5	1.6	1.2	0.5	1.0	1.4
Fed-up feelings	0.4	0.8	3.0	1.4	-0.3	-0.3	0.0	1.7	-0.5	0.3
Supplements: Glucosamine	0.4	0.6	1.7	0.1	-0.3	-0.0	-0.8	-1.3	-0.8	-0.9
Forced vital capacity (FVC)	0.4	1.5	4.3	0.8	-0.3	-1.0	-1.5	-1.3	-0.9	-2.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.4	0.4	-0.7	1.2	0.8	-0.2	-0.6	-0.0
Pain all over the body in last month	0.4	0.4	0.7	-0.5	0.9	-0.7	-0.7	0.6	0.8	0.3
Illnesses of siblings	0.4	0.5	1.6	0.0	0.5	-1.3	-1.0	0.8	0.2	0.0
Mouth/teeth dental problems: Dentures	0.4	0.7	2.9	0.9	-0.1	-0.6	-0.0	1.7	-0.1	0.7
Illnesses of mother	0.4	0.5	1.3	1.1	-0.7	-0.6	0.4	0.8	-0.8	0.1
Birth weight of first child	0.4	0.8	1.9	1.0	-0.9	0.8	1.4	0.3	-1.0	0.2
Loud music exposure frequency	0.4	0.4	1.2	-0.2	0.6	-1.1	-0.3	-0.6	0.2	-0.8
Headache pain in last month	0.4	0.7	3.1	-0.5	0.0	0.1	-0.4	1.8	0.4	0.9
Forced vital capacity (FVC), Best measure	0.4	1.5	4.1	0.5	-0.2	-1.3	-1.7	-1.0	-0.9	-2.0
Body fat percentage	0.4	1.6	3.8	-2.0	0.5	1.5	1.0	0.5	1.2	1.4
Leg fat percentage (right)	0.4	1.5	4.2	-2.0	0.7	1.1	0.5	0.6	1.4	1.4
Eye problems/disorders: None of the above	0.4	0.5	1.2	-0.3	0.6	-0.9	-0.7	-0.8	-0.0	-1.1
Angina (self-reported)	0.4	0.5	1.7	0.3	-0.5	-0.1	1.1	1.3	-0.6	0.3
Medication: Omeprazole	0.4	0.5	1.7	-0.7	0.0	0.0	-0.6	-0.9	-0.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.7	-0.1	-0.9	-0.9	0.1	-0.5	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	0.3	-0.1	0.8	0.6	-1.4	-0.2	-0.6
Friendships satisfaction	0.4	0.5	1.6	0.3	-0.4	-0.2	0.3	-0.9	-0.9	-1.2
Eye problems/disorders: Cataract	0.4	0.5	1.4	1.1	-0.6	-0.1	0.0	1.2	-0.6	0.4
Eye problems/disorders: Glaucoma	0.4	0.4	1.7	0.4	0.0	0.3	-0.2	1.3	0.4	0.9
Leg fat percentage (left)	0.4	1.6	5.2	-2.3	1.1	0.9	0.4	0.4	1.6	1.2
Fractured/broken bones in last 5 years	0.4	0.5	1.4	-0.5	-0.2	0.8	1.1	-1.2	-0.5	-0.2
Cholesterol lowering medication	0.4	0.6	1.8	0.7	-1.0	0.2	-0.5	0.7	-1.3	-0.5
Depression (Nagel 2018)	0.3	0.4	1.9	0.4	-0.3	-0.0	0.3	1.4	-0.4	0.5
Neuroticism (Nagel 2018)	0.3	0.8	1.9	1.3	-0.6	0.1	0.6	1.4	-1.1	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.7	0.6	-0.3	0.5	0.2	1.0	0.5
Ulcerative Colitis	0.3	0.5	1.4	1.2	-0.6	0.2	0.7	0.2	-1.0	-0.2
Allergy or Eczema	0.3	0.7	2.0	1.4	-0.5	-0.6	0.2	0.4	-1.1	-1.0
Respiratory disease	0.3	0.6	1.0	0.9	-0.8	1.0	0.7	-0.3	-1.0	-0.8
Angina	0.3	0.4	1.4	0.2	-0.4	-0.2	0.9	1.2	-0.6	0.2
Impedance of leg (right)	0.3	1.4	3.6	0.6	0.6	-1.6	-1.2	-1.1	-0.2	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.4	0.8	0.3	-0.9	-0.6	1.2	-0.1	0.4
Hearing difficulty/problems with background noise	0.3	0.5	1.1	0.9	-1.0	0.4	0.5	0.3	-1.0	-0.2
Allergy	0.3	0.6	1.3	-0.5	0.9	-0.7	-1.0	0.4	1.1	0.5
Trunk fat-free mass	0.3	1.9	5.6	0.9	-1.1	-0.3	-0.4	-1.4	-1.8	-2.4
Worrier / anxious feelings	0.3	0.5	1.4	0.3	-0.6	0.6	0.5	1.2	-0.7	0.6
Asthma	0.3	0.6	2.0	-0.0	-0.3	0.8	-0.2	-1.4	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	0.2	0.1	-1.4	-1.5	-0.4	-0.4	-1.4
Arm fat mass (right)	0.3	1.2	2.2	-1.4	0.2	1.4	1.0	0.7	0.8	1.5
Trunk predicted mass	0.3	1.7	5.0	0.8	-1.1	-0.3	-0.4	-1.2	-1.8	-2.2
Hair/balding pattern: Pattern 4	0.3	0.7	2.9	0.3	0.1	-0.9	-1.7	0.2	-0.2	-0.9
Gout (self-reported)	0.3	0.4	0.9	0.1	-0.9	0.0	0.7	0.8	-1.0	0.2
Number of children fathered	0.3	0.4	1.6	-0.6	-0.0	1.3	-0.2	-0.7	0.2	-0.1
Mean time to correctly identify matches	0.3	0.6	2.4	0.8	-0.7	0.1	-0.3	1.5	-0.5	0.9
Suffer from ‘nerves’	0.3	0.5	1.7	1.1	-0.3	-0.5	0.4	1.3	-0.6	0.4
Overall health rating	0.3	0.6	2.1	-0.1	-0.3	0.7	0.8	1.4	-0.3	0.9
Knee pain experienced in last month	0.3	0.5	1.3	-0.6	0.5	-0.5	-0.7	1.1	0.5	0.6
Ever had bowel cancer screening	0.3	0.4	1.1	0.5	0.1	-0.9	-0.6	-0.1	0.0	-1.0
Smoking status: Current	0.3	0.4	1.5	-0.3	-0.1	1.2	0.8	0.0	0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	-0.9	0.3	0.2	-0.3	1.1	0.7	1.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	1.0	-0.2	-0.4	-0.3	1.2	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	-0.3	-0.3	0.3	-0.5	-0.4	-0.6	-1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	0.8	0.6	-1.0	0.0	-0.2	0.2	-0.5
Reaction Time	0.2	0.4	0.9	0.2	-0.5	0.6	-0.5	1.0	-0.2	0.8
LDL Cholesterol	0.2	0.4	0.6	0.6	-0.8	0.6	0.4	0.7	-0.8	0.2
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.6	-0.4	0.7	0.9	-0.3	-0.1	0.2
Neuroticism	0.2	0.5	1.3	1.2	-0.6	0.2	0.3	0.8	-1.0	-0.3
Chronotype (morning person)	0.2	0.5	2.2	-0.1	-0.1	1.5	-0.2	-0.1	0.3	1.1
Severe depression (siblings)	0.2	0.2	0.6	0.3	-0.6	0.3	0.8	0.2	-0.7	0.2
Current tobacco smoking	0.2	0.3	1.5	-0.4	-0.2	1.2	0.6	-0.4	0.2	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.3	0.4	0.2	-0.2	0.8	0.3	0.7
Trunk fat mass	0.2	0.7	1.9	-1.3	0.1	1.4	1.0	0.1	0.4	0.6
Waist circumference	0.2	0.9	3.9	-2.0	0.3	1.2	0.3	-0.1	0.7	0.5
Nervous feelings	0.2	0.4	1.3	0.3	0.7	-0.7	-0.5	1.1	0.5	0.3
Impedance of arm (right)	0.2	0.9	4.1	2.0	-0.5	-0.4	0.4	-0.4	-0.9	-0.8
Time employed in main current job	0.2	0.3	1.5	-0.2	0.2	-0.4	-1.2	0.1	0.0	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.6	0.8	-0.3	-1.0	-0.9	-0.5	-0.6	-1.3
Length of working week for main job	0.2	0.3	1.3	-1.1	0.2	0.1	-0.0	-0.7	0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.6	0.5	-0.3	-0.8	0.1	0.4	-0.4
Medication: Amlodipine	0.2	0.3	1.3	0.3	-0.4	0.2	1.2	0.5	-0.3	0.4
Leg fat mass (right)	0.2	0.8	2.1	-1.4	0.1	1.2	0.7	0.4	0.6	0.9
Pulse rate, automated reading	0.2	0.7	2.3	-0.1	0.9	-1.1	-1.5	-0.1	0.6	-0.7
Whole body fat-free mass	0.2	0.9	2.7	0.4	-0.8	0.0	-0.1	-1.0	-1.4	-1.6
Asthma (self-reported)	0.2	0.4	1.3	-0.1	-0.2	0.4	-0.4	-1.1	-0.5	-0.7
Whole body water mass	0.2	1.0	2.9	0.4	-0.9	0.1	-0.1	-1.1	-1.5	-1.7
Arm fat mass (left)	0.2	1.0	2.1	-1.4	0.1	1.2	0.8	0.7	0.7	1.3
Miserableness	0.2	0.4	1.0	1.0	-0.3	-0.2	0.1	0.9	-0.8	-0.5
Wears glasses or contact lenses	0.2	0.3	0.6	0.2	-0.3	-0.7	0.5	0.1	-0.6	-0.8
Medication: Blood pressure	0.2	0.4	0.7	-0.5	0.2	0.2	0.8	0.8	0.3	0.9
Irritability	0.2	0.4	1.3	0.5	0.5	-0.6	-0.6	-0.5	0.0	-1.2
Diastolic blood pressure, automated reading	0.2	0.7	1.8	-1.4	0.9	-0.5	-1.0	0.1	1.0	0.2
Ever depressed for a whole week	0.2	0.3	1.1	-0.0	0.2	0.1	-0.1	1.0	0.5	0.7
Impedance of whole body	0.2	0.9	2.6	1.6	-0.2	-1.0	-0.1	-0.3	-0.8	-1.3
Leg fat mass (left)	0.2	0.7	2.3	-1.5	0.3	1.0	0.5	0.2	0.7	0.7
Schizophrenia (2018)	0.1	0.3	1.1	-0.6	0.1	-0.3	-0.6	1.1	0.1	0.1
Worry (Nagel 2018)	0.1	0.2	0.7	0.9	0.1	-0.5	0.1	0.4	-0.3	-0.4
Schizophrenia (2014)	0.1	0.2	0.8	-0.2	-0.2	-0.4	-0.4	0.9	-0.4	-0.0
Lung FVC	0.1	0.7	2.1	0.0	-0.7	0.8	0.2	-1.4	-0.8	-1.0
Hair Pigment	0.1	3.6	11.2	-1.8	1.7	-1.1	-1.4	-3.3	0.9	-2.0
Leg fat-free mass (left)	0.1	0.4	0.9	0.0	-0.8	0.8	0.4	-0.3	-1.0	-0.5
Average weekly fortified wine intake	0.1	0.1	0.5	0.3	-0.1	0.2	0.7	-0.5	-0.0	-0.5
Maternal smoking around birth	0.1	0.2	0.5	0.7	0.1	-0.6	0.4	0.2	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.4	-0.2	0.0	0.2	-0.1	-0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	0.5	-0.0	-0.8	-0.2	-0.2	-0.6	-0.9
Medication: Atenolol	0.1	0.1	0.4	-0.6	0.2	0.2	0.6	0.1	0.3	0.1
Leg predicted mass (left)	0.1	0.4	1.0	0.1	-0.8	0.7	0.4	-0.2	-1.0	-0.4
Neuroticism score	0.1	0.2	0.7	0.6	0.1	-0.2	-0.5	0.2	-0.5	-0.8
Weight	0.1	0.3	0.9	-0.8	-0.3	0.9	0.4	-0.3	-0.3	-0.3
Hip circumference	0.1	0.4	1.4	-1.2	0.1	1.0	-0.0	0.0	0.4	0.4
Falls in the last year	0.1	0.1	0.3	-0.3	0.2	-0.2	-0.3	0.6	0.1	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.4	0.3	0.2	-0.5	-0.5	0.4	0.2
Pulse rate	0.1	0.2	0.8	-0.2	0.5	-0.2	-0.9	0.3	0.2	-0.1
Impedance of arm (left)	0.1	0.6	2.7	1.6	-0.2	-0.9	0.2	0.2	-0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	0.1	-0.1	-0.5	-0.0	-0.9	-0.3	-0.8
Medication: Paracetamol	0.1	0.2	0.5	-0.5	-0.5	0.7	0.3	0.3	-0.4	0.2
Birth weight	0.1	0.3	0.6	0.8	-0.2	-0.6	0.2	0.4	-0.7	-0.2
Arm fat-free mass (right)	0.1	0.7	2.4	-0.5	-0.3	-0.2	-0.5	-1.0	-0.8	-1.5
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.1	-0.3	0.5	-0.4	-0.2	-0.4	0.2
Whole body fat mass	0.1	0.6	1.5	-1.2	0.1	1.2	0.8	0.2	0.5	0.7
Arm predicted mass (right)	0.1	0.7	2.7	-0.2	-0.4	-0.2	-0.4	-0.9	-0.9	-1.6
Leg fat-free mass (right)	0.1	0.3	0.7	0.1	-0.6	0.4	0.2	-0.5	-0.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.4	0.2	-0.5	-0.3	-0.2	0.1	-0.5
Medication for cholesterol	0.1	0.2	0.9	0.9	-0.4	0.1	-0.0	0.0	-0.5	-0.1
Leg predicted mass (right)	0.1	0.3	0.8	0.1	-0.6	0.3	0.2	-0.5	-0.9	-0.8
Financial situation satisfaction	0.1	0.1	0.4	-0.7	0.3	0.1	0.1	-0.1	0.3	-0.3
Basal metabolic rate	0.1	0.6	1.8	0.1	-0.7	0.3	-0.1	-0.9	-1.1	-1.3
Arm fat-free mass (left)	0.1	0.6	1.5	0.1	-0.8	0.3	0.0	-0.6	-1.2	-1.2
Arm predicted mass (left)	0.1	0.6	1.7	-0.1	-0.7	0.4	0.1	-0.8	-1.1	-1.3
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.3	-0.3	0.0	-0.0	0.4	-0.3	-0.2

Hub : Genes

PTPLAD1

Models

Trait associations