Hub : Genes

DENND4A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0180	1.4e-05	0.050	0.042	0.051	0.051	0.043	9.6e-07	6.5e-06	7.1e-07	7.3e-07	5.9e-06
2	GTEx	Artery Tibial	0.0489	0.0231	6.2e-03	0.012	NA	0.021	NA	0.015	3.7e-02	NA	8.3e-03	NA	2.1e-02
3	GTEx	Brain Cerebellar Hemisphere	0.2870	0.1230	4.8e-03	-0.010	NA	0.037	NA	0.008	7.0e-01	NA	4.0e-02	NA	1.9e-01
4	GTEx	Brain Nucleus accumbens basal ganglia	0.1580	0.0660	5.6e-03	0.095	NA	0.028	NA	0.064	1.6e-03	NA	6.0e-02	NA	8.8e-03
5	GTEx	Cells Transformed fibroblasts	0.0800	0.0300	5.5e-04	0.056	NA	0.023	NA	0.043	4.7e-05	NA	7.6e-03	NA	3.3e-04
6	GTEx	Pituitary	0.1900	0.0740	2.6e-03	0.119	NA	0.103	NA	-0.008	6.6e-04	NA	1.5e-03	NA	5.9e-01
7	TCGA	Breast Invasive Carcinoma	0.0143	0.0104	9.5e-03	0.006	0.008	0.003	NA	0.004	1.9e-02	7.5e-03	7.6e-02	NA	4.1e-02
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0396	0.0260	6.5e-03	0.010	0.015	0.011	NA	0.008	2.5e-02	8.0e-03	1.6e-02	NA	4.1e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0450	0.0300	6.3e-03	0.019	0.021	0.011	NA	0.013	1.7e-02	1.3e-02	5.4e-02	NA	4.1e-02
10	TCGA	Rectum Adenocarcinoma	0.1690	0.1010	1.8e-03	0.081	0.070	-0.012	NA	0.007	6.1e-03	1.0e-02	8.2e-01	NA	2.2e-01
11	TCGA	Soft Tissue Sarcoma	0.1320	0.1000	9.3e-03	0.007	0.027	0.008	NA	0.020	1.1e-01	9.5e-03	1.0e-01	NA	2.4e-02
12	TCGA	Testicular Germ Cell Tumors	0.0900	0.0580	8.6e-03	0.049	0.017	0.021	NA	0.029	7.9e-03	8.0e-02	6.2e-02	NA	3.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.6	1.0	2.7	-0.9	-0.7	0.4	-1.1	0.8	0.5	1.1	1.6	1.2	0.4	1.6	0.6
Bipolar Disorder or Schizophrenia	0.2	0.6	3.1	-0.1	-0.3	-0.4	-0.9	-0.1	0.9	0.4	1.1	0.4	-0.2	1.8	-0.3
Depressed Affect (Nagel 2018)	0.9	1.9	3.9	1.6	1.6	0.2	0.7	-2.0	1.5	-0.7	-0.2	-1.2	-1.7	1.5	-1.9
Depression (Nagel 2018)	0.7	1.1	2.4	1.4	1.1	0.1	0.3	-1.3	1.4	-0.2	0.4	-0.6	-1.3	1.5	-1.4
Intelligence (Savage-Jansen 2018)	4.5	13.7	22.3	4.2	4.2	1.1	3.9	-4.7	3.3	-3.8	-2.5	-4.4	-4.1	1.6	-4.5
Neuroticism (Nagel 2018)	0.8	2.0	4.1	1.8	1.6	0.6	0.9	-1.9	1.5	-0.9	-0.2	-1.3	-1.5	1.6	-2.0
Schizophrenia (2018)	0.2	0.4	1.0	0.5	0.2	-0.8	-0.3	-0.7	0.8	-0.4	0.2	-0.4	-0.5	1.0	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.6	0.8	-0.9	0.6	-1.0	0.4	-0.8	-0.6	-0.9	-0.8	-0.1	-0.7
Worry (Nagel 2018)	0.3	0.7	2.2	1.5	0.9	0.5	0.3	-1.0	0.3	-0.9	-0.7	-0.9	-0.5	0.4	-1.2
Alzheimer’s Disease (in mother)	1.4	1.7	2.8	1.7	1.6	0.4	1.2	-1.4	1.4	-1.1	-0.4	-1.4	-1.6	1.3	-1.4
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.1	-0.5	-1.1	-0.7	-0.1	0.3	0.1	0.3	0.3	0.3	0.5	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.7	1.3	0.6	-0.5	0.2	-1.0	0.5	-0.8	-0.6	-0.7	-0.5	0.2	-1.0
Crohns Disease (2017)	1.6	3.5	5.5	-2.2	-2.2	-0.6	-1.6	2.2	-0.4	2.3	2.2	2.3	1.6	0.5	2.3
Irritable Bowel Disease (IBD)	0.7	1.6	4.9	-1.4	-1.0	0.8	-0.4	1.1	0.9	1.6	2.2	1.4	0.3	1.8	1.0
Ulcerative Colitis (UC)	0.4	0.8	2.9	-0.1	0.5	1.3	0.9	-0.4	1.5	0.2	0.9	-0.0	-0.9	1.7	-0.5
Major Depression (MDD)	2.3	2.8	4.8	-1.3	-2.0	-1.0	-2.2	1.8	-1.3	1.8	1.8	2.1	1.8	0.2	1.7
Reaction Time	0.3	0.6	4.7	-0.6	-0.4	2.2	-0.5	0.3	0.6	0.3	0.7	0.4	0.3	0.8	0.2
Verbal and Numeric Reasoning (VNR)	3.7	8.9	15.2	3.6	3.1	0.4	2.9	-3.9	1.9	-3.6	-2.8	-3.8	-2.8	0.4	-3.8
Breast Cancer	1.3	3.2	5.0	2.2	2.0	1.4	1.9	-2.2	1.1	-2.0	-1.6	-2.1	-1.8	0.1	-2.1
Ovarian Cancer	0.5	0.6	3.2	-0.0	0.6	0.2	-0.1	-0.8	1.2	-0.1	0.8	-0.2	-0.7	1.8	-0.8
Prostate Cancer	0.9	1.3	3.2	-1.0	-1.8	-1.1	-1.4	1.2	-0.9	0.8	0.6	1.2	1.5	-0.6	1.1
Age at First Birth	1.4	2.0	4.7	0.1	1.8	0.7	1.8	-1.5	2.2	-0.3	0.3	-1.0	-2.1	1.7	-1.3
Bipolar Disorder (2011)	2.6	2.5	4.7	-1.8	-1.5	1.3	-1.1	1.8	0.1	2.1	2.2	2.0	1.0	1.0	1.7
Body Mass Index (BMI) (2010)	3.8	5.2	8.8	-3.0	-2.5	0.0	-2.4	2.9	-1.2	2.5	2.2	2.8	2.2	0.3	2.6
Coronary Artery Disease (CAD)	0.5	0.6	2.6	-0.7	-0.2	0.4	-0.4	-0.1	1.1	0.8	1.2	0.5	-0.5	1.6	-0.1
Crohns Disease (2012)	1.7	2.8	6.6	-2.6	-1.5	-0.0	-0.9	2.1	-0.0	2.2	2.1	2.1	0.9	0.5	2.1
Mean Putamen Volume	1.6	1.8	3.0	-1.3	-1.4	-1.2	-1.5	1.5	-0.8	1.7	1.3	1.7	1.3	-0.0	1.6
Fasting Glucose	0.4	0.5	1.7	0.5	0.6	-0.0	0.7	-0.4	1.2	-0.2	0.6	-0.3	-0.4	1.3	-0.7
HbA1C	0.5	0.6	1.8	0.1	0.6	0.8	0.8	-0.8	1.4	-0.1	0.5	-0.3	-1.0	1.1	-0.7
HDL Cholesterol	2.0	3.3	8.0	1.8	2.5	1.2	2.8	-1.9	1.8	-1.4	-0.9	-2.1	-2.2	0.4	-1.4
LDL Cholesterol	0.3	0.5	1.8	0.1	0.8	0.8	0.6	-0.6	1.0	0.0	0.4	-0.4	-0.9	1.3	-0.6
Lupus	0.8	1.2	2.6	0.8	1.2	1.6	1.3	-1.0	1.2	-1.0	-0.4	-1.2	-1.2	0.7	-1.2
Neuroticism (2016)	0.5	0.7	1.3	1.0	1.0	1.1	0.8	-0.7	0.8	0.1	0.3	-0.3	-1.1	1.1	-0.7
Primary Biliary Cirrhosis	0.2	0.3	1.2	-0.3	-0.4	1.1	-0.0	0.9	-0.1	0.5	0.3	0.5	0.5	-0.2	0.7
Rheumatoid Arthritis	0.3	0.4	1.0	0.7	0.1	-0.8	-0.6	-0.2	-1.0	-0.8	-0.9	-0.3	0.7	-0.8	-0.2
Schizophrenia (2014)	0.4	1.0	2.1	1.2	0.8	-0.4	0.1	-1.3	1.1	-1.1	-0.3	-1.0	-1.0	1.1	-1.4
Triglycerides	0.5	0.9	4.2	-0.2	0.5	0.4	0.3	-0.6	1.6	0.2	0.9	-0.2	-1.0	2.0	-0.8
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.6	-0.8	-1.3	-0.6	-1.6	1.2	-0.8	0.4	0.4	1.1	1.4	-0.3	0.8
Ulcerative Colitis	0.2	0.3	0.8	0.4	0.7	0.7	0.9	-0.3	0.5	-0.6	-0.2	-0.4	-0.4	0.4	-0.5
Blood Eosinophil Count	0.8	6.3	23.2	-0.7	-2.4	-4.8	-3.2	1.4	-3.5	0.4	-0.8	1.4	3.2	-2.7	1.3
Blood Platelet Count	0.2	2.1	4.9	2.1	0.6	-1.9	-0.9	-2.1	0.1	-1.6	-1.5	-1.2	-0.4	0.2	-2.2
Blood Red Count	10.3	99.8	196.0	7.7	12.5	9.2	14.0	-9.4	12.7	-6.1	-2.2	-9.7	-12.8	7.9	-9.5
Blood White Count	0.6	4.4	15.0	1.9	1.5	-0.5	0.4	-2.4	3.3	-0.2	1.3	-0.8	-2.6	3.9	-2.6
Heel T-Score	8.4	67.1	112.4	-7.9	-10.4	-3.2	-10.6	9.3	-8.5	6.4	4.5	9.1	10.3	-4.4	9.1
BMI	1.5	8.5	16.6	-4.1	-2.5	0.7	-2.1	4.0	-0.6	4.0	3.4	3.6	2.2	0.7	3.5
Height	2.5	48.9	74.3	8.3	8.6	-1.5	7.7	-8.3	4.4	-7.6	-6.7	-8.5	-7.2	0.6	-8.2
Waist Hip Ratio (WHR)	0.3	1.2	3.5	1.4	0.6	-0.4	0.2	-0.6	-1.0	-1.6	-1.9	-1.0	0.2	-1.7	-0.5
Systolic Blood Pressure	0.8	3.8	8.7	-2.3	-2.4	-0.7	-3.0	1.9	-2.0	1.5	1.1	2.1	2.4	-0.8	1.9
Smoking Status	0.4	0.9	2.8	0.6	0.9	1.7	1.7	-0.5	1.1	-0.1	0.3	-0.6	-1.1	0.5	-0.5
Allergy or Eczema	1.2	3.2	7.0	1.8	2.1	-0.6	1.5	-2.6	1.2	-1.9	-1.2	-2.1	-1.9	0.8	-2.4
Cardiovascular Disease	1.7	5.5	12.1	-3.1	-2.2	1.2	-1.7	2.5	0.7	3.1	3.5	2.8	1.2	2.0	2.2
Hypothyroidism (self reported)	2.4	5.5	11.0	-3.1	-2.1	1.6	-2.4	2.4	0.2	2.9	3.3	3.0	1.4	1.7	2.2
Respiratory disease	0.2	0.5	1.1	1.0	1.0	-0.7	1.0	-0.4	0.5	-0.4	-0.4	-0.6	-0.7	0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.8	0.4	0.9	1.6	1.0	-0.3	1.9	0.4	0.6	-0.3	-1.2	1.3	-0.3
Lung FEV1/FVC ratio	0.6	3.2	7.8	-2.3	-2.7	-0.5	-2.8	1.4	-0.2	1.4	2.0	2.0	1.9	1.0	1.2
Lung FVC	0.2	1.1	9.8	0.3	0.4	3.1	1.1	-0.4	0.3	-0.7	-0.6	-0.7	-0.4	-0.5	-0.4
Neuroticism	0.8	1.9	3.5	1.9	1.5	0.9	1.0	-1.7	1.2	-1.2	-0.5	-1.3	-1.4	1.2	-1.9
Chronotype (morning person)	0.6	1.5	2.4	-1.3	-1.4	1.4	-0.7	1.5	-0.5	1.4	1.3	1.4	1.1	-0.1	1.5
Hair Pigment	0.1	3.7	12.2	1.7	0.7	-1.2	0.3	-0.9	-2.2	-2.4	-3.4	-1.6	0.8	-3.5	-0.8
Tanning	0.6	7.1	13.2	-3.6	-2.3	2.5	-1.9	3.2	-0.7	3.4	3.3	3.2	1.8	0.8	3.0
Hand grip strength (left)	1.6	4.3	9.9	2.4	1.4	-2.0	1.8	-2.3	0.1	-3.2	-2.5	-2.6	-0.7	-0.9	-2.5
Number of treatments/medications taken	1.9	3.4	8.5	-1.9	-0.7	2.6	-0.1	1.5	1.4	2.7	2.9	1.8	-0.4	2.2	1.5
Average weekly spirits intake	1.2	1.5	4.0	-1.7	-2.0	0.5	-1.4	1.3	-0.9	1.0	1.0	1.3	1.5	-0.1	1.1
Sensitivity / hurt feelings	2.1	3.7	9.6	-1.3	-2.4	-1.9	-3.1	1.8	-1.9	1.7	1.3	2.2	2.2	-0.1	1.5
Frequency of depressed mood in last 2 weeks	0.9	1.2	4.4	1.3	0.6	0.5	0.2	-1.2	1.7	-0.1	0.9	-0.4	-1.3	2.1	-1.2
Hearing difficulty/problems: Yes	0.5	0.8	4.1	0.5	0.2	-0.9	-0.8	-0.7	1.1	0.5	1.2	0.2	-0.7	2.0	-0.6
Relative age of first facial hair	0.4	0.8	1.4	1.0	1.1	0.6	0.9	-0.9	1.2	-0.6	0.0	-0.7	-1.1	1.1	-1.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.7	-0.8	0.5	2.2	0.2	-0.2	1.2	1.7	1.8	0.6	-1.5	1.7	0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.9	0.6	0.9	-0.4	1.4	-0.7	0.9	-0.7	-0.4	-1.0	-0.8	0.3	-0.6
Ever had hysterectomy (womb removed)	1.1	1.3	3.1	1.8	1.2	-0.6	0.6	-1.5	0.6	-1.2	-1.0	-1.4	-1.2	0.2	-1.3
Systolic blood pressure, automated reading	0.6	1.6	4.4	-0.9	-1.3	-1.9	-1.4	0.7	-2.1	-0.1	-0.7	0.5	1.5	-1.8	0.7
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	5.1	2.1	2.1	-0.9	1.5	-2.3	1.4	-1.8	-1.4	-2.0	-2.0	0.6	-2.2
Angina	0.4	0.5	2.2	0.2	0.6	-0.4	0.2	-0.5	1.1	0.2	0.7	-0.2	-0.9	1.5	-0.5
Medication for hormone replacement therapy	1.1	1.3	2.8	-0.4	-0.8	-1.3	-0.6	1.6	-1.4	0.5	-0.2	0.8	1.4	-1.5	1.7
Vitamin and mineral supplements	1.9	2.6	6.3	-1.0	-1.3	-1.6	-1.5	1.4	-2.5	-0.1	-1.0	0.7	2.5	-2.5	1.2
Supplements: Zinc	1.3	1.4	3.8	-1.5	-0.6	0.6	-0.4	0.9	0.6	1.9	1.9	1.3	-0.2	1.3	1.0
Medication: Co-codamol	0.9	1.1	2.6	0.9	1.0	0.6	1.6	-1.0	1.1	-1.0	-0.7	-1.2	-0.9	0.4	-1.4
Medication: Metformin	0.4	0.6	1.8	0.0	0.6	1.0	1.1	0.0	1.4	0.5	0.5	-0.1	-1.1	0.8	0.0
Diabetes (father)	2.9	3.6	7.8	1.2	1.9	1.7	1.8	-2.0	2.8	-0.4	0.4	-1.3	-2.8	2.4	-2.0
Diabetes (mother)	0.2	0.3	0.8	0.6	0.3	-0.7	0.6	-0.4	0.1	-0.5	-0.9	-0.6	-0.1	-0.9	-0.2
Severe depression (siblings)	0.3	0.3	2.0	0.5	0.6	1.4	0.2	-0.2	0.5	-0.1	0.3	-0.1	-0.5	0.7	-0.1
Pack years adult smoking proportion	1.4	2.1	3.8	-1.2	-1.6	-0.2	-1.9	1.5	-0.9	1.9	1.5	1.9	1.3	-0.1	1.6
Impedance of leg (right)	0.8	3.8	7.9	2.8	1.8	0.1	1.6	-2.3	0.1	-2.6	-2.5	-2.4	-1.1	-0.9	-2.1
Leg fat-free mass (left)	0.1	0.4	1.8	0.1	0.9	-1.3	0.6	-0.5	0.6	-0.2	-0.2	-0.5	-0.8	0.4	-0.7
Trunk fat percentage	1.0	4.1	8.0	-2.1	-1.9	-0.8	-1.8	2.7	-1.4	2.8	2.1	2.6	1.6	-0.0	2.5
Hand grip strength (right)	2.3	6.2	12.5	2.7	2.1	-1.3	2.5	-3.2	1.3	-3.5	-2.5	-3.1	-1.8	0.0	-3.4
Townsend deprivation index at recruitment	0.8	1.1	2.9	-1.1	-0.7	0.5	-0.6	1.1	0.2	1.7	1.7	1.3	0.2	1.0	1.1
Current tobacco smoking	0.1	0.2	0.6	-0.2	-0.5	0.3	-0.1	0.8	-0.3	0.5	0.4	0.6	0.5	-0.3	0.6
Average weekly fortified wine intake	0.1	0.1	0.4	-0.2	-0.2	0.4	0.1	-0.2	0.1	-0.6	-0.1	-0.2	0.3	-0.1	-0.2
Maternal smoking around birth	0.2	0.2	1.3	1.1	0.4	0.1	0.0	-0.6	0.2	-0.3	-0.1	-0.3	-0.6	0.4	-0.6
Fed-up feelings	0.6	1.0	3.4	0.6	0.7	0.7	0.2	-1.4	1.4	-0.1	0.5	-0.5	-1.2	1.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.0	0.7	0.0	1.0	-0.4	-0.4	0.3	0.1	0.3	0.0	0.0	0.5	-0.4
Relative age voice broke	0.1	0.2	0.6	0.4	0.3	0.7	0.8	0.0	0.4	-0.1	0.3	-0.1	-0.3	0.5	-0.1
Taking other prescription medications	0.8	1.2	3.0	-1.2	-0.0	1.2	0.1	1.0	0.9	1.7	1.7	1.0	-0.3	1.2	0.9
Age when periods started (menarche)	3.5	8.5	15.4	-2.8	-3.5	-1.6	-2.9	3.9	-2.7	2.5	1.7	3.3	3.5	-1.5	3.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.3	1.4	0.8	-1.4	0.6	-1.3	0.1	-1.5	-1.3	-1.3	-0.6	-0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	4.3	9.9	19.2	-2.9	-4.0	-1.8	-4.4	3.4	-3.3	2.5	1.6	3.5	3.8	-1.7	3.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.4	-0.1	0.3	-0.4	0.2	-0.4	-0.4	-0.3	-0.2	-0.3	-0.2
Qualifications: CSEs or equivalent	0.7	0.9	2.5	-0.7	-1.2	0.3	-1.6	0.9	-1.0	0.7	0.6	1.1	1.2	-0.2	0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.6	-0.9	-0.7	-1.1	-1.3	0.7	-0.8	0.7	0.7	0.8	0.8	-0.2	0.7
High blood pressure	1.1	3.1	8.8	-2.3	-1.3	0.4	-0.9	1.5	1.1	2.6	3.0	2.1	0.2	2.0	1.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.2	0.8	1.2	-0.3	1.1	-1.4	0.4	-1.5	-1.2	-1.4	-0.8	-0.0	-1.3
Multivitamins +/- minerals	1.5	1.9	4.7	1.1	1.3	0.8	1.6	-1.4	2.0	-0.3	0.6	-0.9	-2.2	1.9	-1.2
Stomach or abdominal pain in last month	0.3	0.4	1.0	-0.7	-0.4	-0.6	-0.1	0.8	0.2	1.0	1.0	0.7	0.3	0.3	0.9
Supplements: Glucosamine	0.6	0.8	1.7	1.2	0.7	-0.8	1.3	-0.9	0.3	-1.1	-1.1	-1.1	-0.7	-0.6	-0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.3	-0.6	0.4	1.1	0.3	0.2	0.8	0.6	0.9	0.2	-0.5	1.1	0.1
Medication: Atenolol	0.5	0.7	1.4	-0.8	-0.8	-1.0	-0.9	1.2	-0.7	0.7	0.4	0.9	0.9	-0.3	0.9
Medication: Levothyroxine sodium	1.3	2.2	5.9	-1.5	-0.4	2.0	-0.8	0.9	1.3	1.5	2.4	1.3	0.0	2.4	0.8
Sitting height	2.2	15.3	26.1	4.6	3.7	-3.3	2.8	-5.0	0.6	-5.1	-4.9	-4.8	-2.6	-1.3	-4.9
Chronic bronchitis/emphysema (father)	1.3	1.5	3.2	-0.8	-1.0	1.0	-1.0	1.7	-0.4	1.8	1.4	1.7	0.8	0.0	1.8
High blood pressure (mother)	3.8	5.4	9.0	-2.9	-3.0	-0.5	-2.3	2.8	-1.4	2.6	2.3	2.8	2.3	-0.2	2.7
Body mass index (BMI)	1.8	7.9	13.5	-3.4	-2.9	-0.2	-2.7	3.7	-1.4	3.6	2.9	3.5	2.5	0.2	3.3
Impedance of leg (left)	1.0	4.9	9.7	3.1	1.9	-0.6	1.7	-2.5	-0.3	-3.1	-3.1	-2.8	-1.0	-1.4	-2.4
Leg predicted mass (left)	0.1	0.5	1.8	0.1	0.9	-1.3	0.6	-0.6	0.7	-0.2	-0.2	-0.5	-0.9	0.5	-0.8
Trunk fat mass	0.4	1.6	3.3	-1.3	-1.0	-1.0	-1.0	1.7	-0.8	1.8	1.4	1.6	0.9	0.1	1.5
Waist circumference	0.5	1.9	3.8	-1.4	-1.3	-0.6	-1.2	2.0	-1.0	1.7	1.2	1.7	1.3	-0.2	1.7
Number of incorrect matches in round	0.7	1.2	2.8	0.3	1.0	1.5	1.6	-0.5	1.7	-0.1	0.5	-0.7	-1.4	1.4	-0.7
Past tobacco smoking	0.6	1.2	3.3	-1.0	-1.1	-1.0	-1.8	1.2	-0.6	1.1	0.8	1.4	1.0	0.2	1.1
Alcohol usually taken with meals	1.4	2.2	4.2	1.8	1.6	1.0	1.5	-1.6	-0.1	-2.0	-2.0	-1.9	-0.7	-0.9	-1.6
Nervous feelings	0.1	0.1	0.6	0.5	-0.0	-0.4	-0.7	-0.1	0.1	0.2	0.1	0.1	0.1	0.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.7	1.7	0.6	0.7	-0.1	-1.5	0.5	-0.7	-0.3	-0.7	-0.9	0.9	-1.6
Hearing difficulty/problems with background noise	0.5	0.8	1.4	1.0	1.0	0.8	1.0	-1.0	1.2	-0.5	-0.2	-0.8	-1.0	0.7	-1.0
Hair/balding pattern: Pattern 2	0.9	1.2	1.7	-1.2	-1.3	0.5	-1.2	1.1	-1.1	1.1	0.5	1.3	1.1	-1.0	1.2
Had menopause	2.7	3.4	5.4	2.2	2.2	0.3	2.3	-2.1	1.8	-1.7	-1.0	-2.2	-2.1	0.9	-1.8
Had other major operations	0.1	0.1	0.8	0.0	-0.1	0.4	-0.9	-0.3	-0.1	0.5	0.3	0.4	-0.2	0.2	0.2
Forced vital capacity (FVC)	0.9	3.4	6.5	1.8	1.8	-0.2	1.8	-2.3	0.5	-2.6	-2.3	-2.4	-1.4	-0.6	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.8	12.7	-3.0	-3.5	-1.8	-3.6	3.1	-2.8	2.3	1.5	3.1	3.3	-1.5	3.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	0.5	0.5	0.1	0.7	-0.4	0.5	-0.2	-0.2	-0.4	-0.4	-0.0	-0.4
Qualifications: None of the above	1.3	2.8	4.9	-1.7	-1.6	1.3	-1.7	2.2	-0.5	2.2	1.7	2.2	1.3	0.3	2.0
Financial difficulties in last 2 years	3.5	4.7	8.9	3.0	2.3	1.2	2.2	-2.6	2.3	-1.9	-1.1	-2.3	-2.3	1.4	-2.6
Mouth/teeth dental problems	3.1	4.8	14.8	-1.1	-2.2	-1.8	-1.5	1.7	-3.6	-0.1	-1.5	0.9	3.0	-3.9	1.7
Heart attack	0.2	0.2	1.1	-0.3	-0.6	-1.0	-0.8	0.2	-0.1	0.2	0.4	0.4	0.4	0.4	0.1
Allergy	0.2	0.4	1.2	-0.1	-1.0	-0.5	-1.1	0.5	-0.8	0.4	0.2	0.7	0.8	-0.4	0.4
Pain all over the body in last month	0.4	0.4	1.0	-0.7	-0.9	0.2	-1.0	0.3	-1.0	0.7	0.1	0.7	0.6	-0.6	0.5
Diabetes (self-reported)	0.7	1.0	2.2	1.1	1.2	1.5	1.5	-0.7	1.3	-0.5	-0.4	-1.0	-1.2	0.4	-0.6
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.7	0.7	0.5	-0.1	0.4	-0.7	-0.9	-1.4	-1.9	-1.0	0.2	-1.4	-0.8
Medication: Ramipril	1.2	1.5	3.5	-1.8	-0.7	0.8	-1.2	0.9	0.6	1.7	1.9	1.4	0.2	1.3	1.1
Medication: Simvastatin	0.9	1.3	5.0	-0.6	0.2	1.2	0.2	0.4	1.7	1.1	1.8	0.5	-0.8	2.2	0.3
Fluid intelligence score	2.7	5.6	9.4	3.1	2.6	1.1	2.1	-3.0	1.5	-2.7	-2.3	-2.9	-2.3	0.2	-2.8
Illnesses of siblings	0.6	0.9	2.9	0.7	0.8	-1.7	-0.1	-1.3	0.3	-0.9	-0.7	-0.9	-0.7	0.3	-1.4
Neuroticism score	0.5	1.0	2.8	1.7	1.0	0.2	0.7	-1.2	0.6	-1.2	-0.6	-1.1	-0.6	0.8	-1.3
Weight	0.0	0.2	1.1	-0.5	0.1	-1.0	-0.1	0.5	-0.1	0.6	0.3	0.3	0.0	0.2	0.2
Impedance of arm (right)	0.3	1.6	3.0	1.7	1.5	0.4	1.5	-1.6	0.6	-1.1	-1.1	-1.4	-1.5	-0.1	-1.3
Arm fat percentage (right)	1.9	7.4	13.0	-3.2	-2.9	0.1	-2.6	3.5	-1.3	3.6	3.0	3.5	2.2	0.3	3.3
Trunk fat-free mass	0.9	5.0	8.0	2.2	2.6	-1.1	2.3	-2.6	1.5	-2.7	-2.3	-2.8	-2.0	0.2	-2.8
Hip circumference	0.2	0.8	1.3	-1.1	-1.0	-1.0	-0.8	1.1	-0.6	1.1	0.8	1.1	0.8	0.0	0.8
Time employed in main current job	0.1	0.1	0.2	0.3	0.4	0.1	0.1	-0.3	-0.0	0.0	-0.4	-0.3	-0.2	-0.4	-0.0
Alcohol intake versus 10 years previously	1.5	2.2	5.3	-0.8	-1.8	-1.5	-2.3	1.1	-2.1	0.9	-0.3	1.3	1.7	-1.6	1.2
Father’s age at death	1.3	1.7	3.3	0.8	1.7	1.6	1.8	-1.2	1.7	-0.7	0.1	-1.2	-1.8	1.2	-0.8
Worrier / anxious feelings	0.3	0.6	1.7	1.1	0.7	1.3	0.3	-0.6	0.8	-0.0	0.3	-0.4	-0.7	1.2	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.3	1.9	2.1	-0.9	1.2	-2.5	2.0	-1.4	-0.5	-1.9	-2.2	1.8	-2.5
Falls in the last year	0.0	0.1	0.2	0.4	-0.1	0.4	-0.2	0.1	0.0	0.2	0.3	0.2	0.0	0.4	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	2.3	-1.0	-0.7	1.5	-0.5	0.9	-0.8	0.7	0.1	0.7	0.7	-0.8	0.8
Number of live births	0.9	1.3	3.7	0.6	1.4	0.5	1.2	-1.0	1.9	-0.3	0.3	-0.9	-1.5	1.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.8	1.0	1.0	0.2	1.0	-1.7	0.6	-1.9	-1.5	-1.6	-1.0	-0.1	-1.8
Pulse rate	0.2	0.3	1.6	0.7	0.1	-1.3	0.0	-0.6	-0.2	-0.5	-0.5	-0.4	0.1	-0.2	-0.6
Happiness	0.6	0.8	2.0	1.2	0.5	-0.9	-0.3	-0.7	-0.9	-0.9	-1.4	-0.7	0.0	-1.2	-0.6
Noisy workplace	1.4	1.7	2.9	-1.4	-1.4	-0.3	-1.3	1.7	-1.2	1.2	0.8	1.5	1.6	-0.8	1.6
Qualifications: A levels/AS levels or equivalent	3.1	6.9	11.5	2.9	2.8	0.4	2.6	-3.1	1.0	-3.4	-3.3	-3.4	-2.2	-1.1	-3.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.7	2.0	1.2	-1.2	1.3	-1.4	-0.4	-2.1	-2.2	-1.9	-0.3	-1.2	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.7	3.2	0.2	0.3	-1.2	-0.2	-0.3	1.1	0.6	1.0	0.2	-0.9	1.8	-0.5
Asthma	0.2	0.3	0.7	0.6	0.8	-0.4	0.8	0.3	-0.2	-0.3	-0.7	-0.4	-0.1	-0.9	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.4	-0.1	0.7	1.8	1.1	-0.2	1.0	0.1	0.5	-0.3	-0.9	1.1	-0.5
Medication: Cholesterol lowering	1.0	1.5	4.7	-0.9	-0.7	-0.1	-1.0	0.7	0.9	1.8	2.2	1.3	-0.3	2.1	0.6
Depression (self-reported)	0.6	0.8	2.2	0.5	0.8	1.5	1.1	-0.7	1.2	-0.4	0.2	-0.7	-0.9	1.0	-0.7
Medication: Lansoprazole	3.5	4.0	11.3	-2.7	-1.4	1.9	-0.5	2.1	0.7	2.6	3.4	2.1	0.6	1.9	2.0
Prospective memory result	1.1	1.4	3.6	0.1	-1.3	-1.3	-1.2	0.9	-1.7	-0.3	-0.7	0.5	1.9	-1.6	0.9
Lung cancer (father)	0.6	0.7	2.7	-0.1	-0.5	-0.5	-0.6	0.8	-1.6	0.3	-0.4	0.6	0.9	-1.5	0.8
Illnesses of mother	0.8	1.0	2.5	0.7	1.3	-0.3	0.6	-1.6	0.8	-0.9	-0.7	-1.1	-1.4	0.6	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.5	1.7	1.3	0.4	1.0	-2.2	0.6	-2.6	-2.0	-2.1	-0.9	-0.3	-2.3
Pulse wave Arterial Stiffness index	1.9	2.2	4.8	-2.2	-1.6	0.5	-0.8	1.9	-0.6	1.7	1.8	1.7	1.4	0.2	1.8
Impedance of arm (left)	0.2	1.1	2.2	1.4	1.3	-0.0	1.0	-1.5	0.5	-0.8	-0.9	-1.1	-1.4	0.1	-1.1
Arm fat mass (right)	0.8	3.5	6.2	-2.2	-1.9	-0.6	-1.8	2.4	-0.9	2.5	2.1	2.3	1.5	0.3	2.2
Trunk predicted mass	0.8	4.5	7.5	2.1	2.5	-1.1	2.2	-2.5	1.5	-2.5	-2.1	-2.6	-1.9	0.2	-2.7
Standing height	2.9	29.2	44.6	6.2	6.3	-1.7	5.6	-6.6	3.0	-6.3	-5.5	-6.7	-5.3	0.1	-6.6
Length of working week for main job	0.3	0.3	0.8	-0.9	-0.5	0.1	-0.2	0.6	-0.6	0.0	-0.2	0.3	0.7	-0.7	0.5
Exposure to tobacco smoke at home	0.7	0.8	1.4	1.2	0.9	0.2	1.1	-1.1	0.7	-1.0	-0.7	-1.2	-0.8	0.0	-1.0
Breastfed as a baby	1.3	1.6	3.4	1.1	1.6	-0.0	1.9	-1.3	1.5	-1.3	-0.6	-1.5	-1.4	0.7	-1.2
Tense / ‘highly strung’	0.8	1.3	4.1	2.0	0.5	0.1	0.2	-1.0	-0.9	-1.6	-1.7	-1.1	0.1	-1.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.4	1.2	-0.1	-1.0	-0.0	-0.4	-0.2	-0.4	-0.2	-0.3	0.2	0.1	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	5.2	0.6	0.8	-2.3	0.5	-0.8	0.6	-0.6	-0.4	-0.8	-0.8	0.6	-0.9
Birth weight of first child	0.3	0.5	1.9	0.4	0.7	1.4	0.5	-0.5	0.7	-0.0	0.5	-0.3	-0.9	1.1	-0.5
Peak expiratory flow (PEF)	0.6	1.4	4.3	0.8	0.7	-0.5	0.6	-1.0	-0.6	-2.1	-2.0	-1.5	0.0	-1.4	-1.0
Pulse wave reflection index	0.7	0.9	1.8	-1.2	-0.9	1.3	-0.2	1.4	-0.2	0.7	1.0	0.9	0.8	0.1	1.3
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.7	-1.4	-1.6	0.8	-1.6	1.3	-0.7	1.0	0.9	1.3	1.4	-0.2	1.1
Loud music exposure frequency	0.5	0.5	1.7	1.0	0.6	-0.1	0.3	-0.5	-0.4	-0.8	-1.3	-0.8	-0.3	-0.9	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.7	0.7	0.9	0.8	1.0	-0.9	0.0	-1.2	-1.3	-1.1	-0.6	-0.6	-0.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.3	1.1	1.6	1.6	1.2	-1.4	2.1	-0.8	0.4	-1.1	-1.7	2.1	-1.3
Blood clot in the leg (DVT)	2.8	3.7	6.5	-2.1	-2.6	0.2	-1.9	2.5	-1.2	1.8	1.6	2.3	2.4	-0.4	2.3
Medication: Paracetamol	0.1	0.2	0.7	-0.3	-0.4	0.8	-0.1	-0.0	0.4	0.1	0.6	0.2	0.0	0.7	-0.2
Headache pain in last month	0.2	0.4	1.4	-0.4	-0.6	0.5	-1.2	-0.1	-0.0	0.5	0.9	0.6	0.4	1.0	-0.2
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	6.9	1.9	1.6	-0.4	1.7	-1.9	-0.3	-2.6	-2.6	-2.3	-0.6	-1.6	-1.7
Glaucoma (self-reported)	0.4	0.5	1.7	-0.5	-0.1	0.7	-0.0	0.6	0.6	1.0	1.3	0.7	-0.1	1.0	0.7
Gout (self-reported)	0.6	0.8	2.3	0.7	1.3	-0.5	0.8	-0.8	1.2	0.2	0.1	-0.4	-1.5	1.1	-0.6
Hypothyroidism/myxoedema (self-reported)	3.7	7.2	13.0	-3.4	-2.6	1.8	-2.8	2.9	-0.1	3.2	3.6	3.4	1.9	1.6	2.8
Medication: Amlodipine	0.1	0.2	1.3	-0.3	0.0	1.2	-0.2	-0.1	0.3	0.4	0.4	0.2	-0.4	0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.4	-0.2	0.6	0.7	1.2	0.5	-0.0	-0.1	-0.5	-0.3	-0.2	-0.8	0.4
Birth weight	0.3	0.6	1.1	0.7	1.1	-0.1	0.8	-0.7	0.8	-0.6	-0.2	-0.8	-1.0	0.9	-0.8
Chronic bronchitis/emphysema (mother)	2.3	2.6	7.3	1.9	0.8	-1.9	0.3	-1.5	-1.1	-2.1	-2.7	-1.6	0.1	-2.0	-1.3
High blood pressure (siblings)	0.4	0.6	3.2	-0.2	-0.2	1.8	0.6	0.7	0.6	0.6	1.0	0.4	-0.2	0.6	0.6
Forced vital capacity (FVC), Best measure	1.2	4.4	8.9	2.4	2.1	0.2	1.8	-2.8	0.7	-3.0	-2.5	-2.7	-1.5	-0.3	-2.8
Body fat percentage	1.1	4.5	8.2	-2.3	-2.1	-0.4	-2.0	2.8	-1.4	2.9	2.2	2.7	1.8	-0.0	2.6
Leg fat percentage (right)	0.9	3.3	5.6	-1.9	-2.0	-0.2	-2.0	2.4	-1.1	2.2	1.9	2.2	1.8	0.2	2.1
Arm fat-free mass (right)	0.3	1.4	2.1	1.1	1.4	-1.4	1.1	-1.1	0.5	-1.4	-1.3	-1.5	-0.9	-0.1	-1.4
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.3	0.5	0.2	0.3	0.1	0.3	0.3	0.1	0.0	-0.5	0.2	0.2
Comparative body size at age 10	0.3	0.9	2.2	-1.1	0.1	1.2	0.3	0.7	1.2	1.3	1.5	0.7	-0.4	1.1	0.7
Number of full brothers	1.0	1.2	2.0	1.2	1.2	1.0	1.4	-1.0	0.9	-1.3	-1.1	-1.4	-1.0	-0.2	-1.1
Worry too long after embarrassment	2.0	3.3	10.1	0.6	1.8	2.0	1.9	-1.0	2.9	0.2	1.5	-0.7	-2.3	3.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.8	-0.5	-0.9	-0.6	-1.1	1.0	0.3	1.2	1.3	1.1	0.5	1.0	0.8
Wheeze or whistling in the chest in last year	0.5	0.9	3.3	1.8	0.8	-0.4	1.3	-0.3	-0.4	-1.0	-1.1	-1.0	-0.1	-1.1	-0.2
Number of children fathered	0.7	0.8	2.3	-0.9	-0.6	-0.3	-0.1	1.5	-0.8	0.9	0.9	1.0	1.1	-0.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.3	-1.1	-1.8	-0.7	-1.5	1.7	-1.4	1.0	0.7	1.4	1.8	-0.9	1.5
Age at first live birth	0.6	1.0	1.6	1.1	1.3	0.6	1.2	-1.0	0.7	-1.0	-1.0	-1.1	-1.0	-0.1	-1.1
Pulse wave peak to peak time	3.1	3.7	7.1	2.7	2.1	-0.6	1.3	-2.5	0.8	-2.3	-2.3	-2.3	-1.8	-0.2	-2.3
Health satisfaction	0.5	0.7	2.2	0.5	-0.4	-0.6	-0.3	-0.3	-1.3	-0.9	-1.2	-0.4	0.7	-1.5	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.6	-0.5	-0.0	0.1	-0.5	0.4	0.5	1.1	1.3	0.8	-0.1	1.3	0.5
Qualifications: College or University degree	3.1	9.8	18.0	3.2	3.9	0.8	4.2	-3.4	3.1	-3.0	-2.1	-3.6	-3.8	1.0	-3.4
Eye problems/disorders: None of the above	1.0	1.2	3.7	1.1	0.6	-0.5	0.6	-1.0	-0.0	-1.9	-1.7	-1.4	-0.1	-0.7	-1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	5.6	-0.6	0.5	2.4	1.2	0.2	1.5	0.5	1.1	0.2	-0.9	1.3	0.2
Emphysema/chronic bronchitis	1.0	1.2	3.3	-0.2	1.0	1.0	1.1	-0.5	1.8	0.5	0.9	-0.2	-1.7	1.8	-0.5
Medication for pain relief, constipation, heartburn	1.0	1.7	4.8	1.3	0.7	-1.5	0.7	-0.8	-0.8	-1.8	-2.2	-1.3	0.2	-1.8	-0.7
Neck or shoulder pain in last month	1.3	1.9	7.0	-0.7	-1.6	-2.6	-1.8	0.9	-1.4	0.7	0.6	1.1	1.7	-0.6	1.0
Medication: Blood pressure	2.7	4.8	9.6	-2.7	-2.2	0.1	-2.3	2.3	-0.4	3.1	2.9	2.8	1.2	1.1	2.3
Angina (self-reported)	0.4	0.5	2.4	0.1	0.5	-0.3	0.2	-0.4	1.1	0.3	0.8	-0.1	-0.9	1.6	-0.4
Migraine (self-reported)	2.2	2.7	5.1	-2.3	-2.0	0.4	-1.8	1.7	-1.1	1.8	1.7	2.0	1.6	0.1	1.7
Medication: Ibuprofen	0.6	0.7	6.2	-0.2	0.4	2.5	1.2	0.3	0.4	0.1	0.3	-0.2	-0.4	0.3	0.1
Medication: Allopurinol	1.0	1.3	4.0	-0.8	-0.0	-0.1	-0.6	0.6	1.0	1.7	2.0	1.3	-0.6	2.0	0.6
Medication: Omeprazole	0.8	1.0	1.8	1.3	1.2	-0.3	0.6	-1.3	0.1	-1.1	-1.2	-1.2	-0.8	-0.4	-1.3
Medication: Seretide 50 evohaler	0.8	0.9	2.0	1.0	1.0	-0.6	0.7	-1.4	1.0	-0.4	-0.3	-0.8	-1.4	1.0	-1.1
Mean time to correctly identify matches	0.3	0.6	2.0	-0.5	0.0	1.4	-0.3	-0.1	1.1	0.3	0.9	0.3	-0.3	1.4	-0.1
Heart disease (mother)	0.8	1.0	4.9	-0.6	-1.2	2.2	-0.0	1.1	-0.5	0.5	0.6	0.6	1.0	-0.5	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.7	0.9	1.2	-1.5	0.8	-1.5	0.9	-1.4	-0.8	-1.3	-0.9	0.6	-1.6
Whole body fat mass	0.4	1.5	3.1	-1.4	-1.0	-0.8	-1.1	1.7	-0.7	1.8	1.3	1.5	0.9	0.2	1.4
Leg fat mass (right)	0.4	1.7	3.2	-1.5	-1.2	-0.7	-1.3	1.8	-0.6	1.8	1.5	1.6	1.1	0.3	1.4
Arm predicted mass (right)	0.3	1.7	2.7	1.3	1.6	-1.6	1.2	-1.3	0.7	-1.5	-1.4	-1.6	-1.0	0.1	-1.6
Pulse rate, automated reading	0.2	0.7	2.0	1.4	0.2	-0.8	0.0	-1.0	-0.5	-0.8	-1.2	-0.7	0.0	-0.8	-0.9
Alcohol intake frequency.	0.8	1.9	4.5	-1.5	-1.1	0.3	-1.7	0.9	0.4	2.1	2.0	1.8	0.3	1.4	1.0
Comparative height size at age 10	4.4	24.2	38.6	5.9	5.7	-0.9	4.9	-6.0	2.5	-6.0	-5.4	-6.2	-4.2	-0.4	-6.0
Number of full sisters	1.1	1.4	4.7	0.1	-1.0	-1.3	-0.6	0.6	-1.8	-0.8	-1.3	-0.0	1.7	-2.2	0.3
Suffer from ‘nerves’	0.5	0.9	2.5	1.3	0.7	0.6	0.3	-1.0	1.3	-0.4	0.3	-0.5	-1.0	1.6	-0.9
Overall health rating	0.2	0.4	1.2	-0.0	0.1	-0.4	-0.4	-0.0	0.6	1.1	1.0	0.5	-0.5	1.0	0.3
Chest pain or discomfort	0.7	1.1	2.3	0.9	1.1	1.0	1.2	-1.0	1.5	-0.6	0.0	-0.9	-1.2	1.3	-0.9
Had major operations	1.2	1.4	2.8	0.8	1.7	1.6	1.6	-0.8	1.4	-0.6	-0.3	-1.1	-1.5	1.0	-0.9
Age at last live birth	1.4	2.0	3.1	1.7	1.6	0.1	1.4	-1.7	0.6	-1.8	-1.7	-1.7	-1.2	-0.4	-1.8
Family relationship satisfaction	2.8	3.5	7.2	2.5	2.1	0.2	1.4	-2.2	0.1	-2.3	-2.7	-2.3	-1.1	-1.4	-1.9
Leg pain on walking	0.9	1.1	2.2	-1.1	-0.9	-0.6	-1.3	1.1	-0.9	1.5	0.9	1.4	0.8	-0.2	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.6	-0.4	-0.9	-1.9	-1.9	0.6	-1.4	0.8	0.1	0.9	1.1	-0.5	0.6
Commuting to job workplace: Car/motor vehicle	2.8	3.2	5.6	-2.1	-1.9	0.2	-1.9	2.0	-2.4	1.0	0.3	1.7	2.4	-1.7	2.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.1	-1.2	-1.2	0.1	-1.3	1.2	-1.4	0.5	-0.0	1.0	1.3	-1.3	1.3
Medication: Aspirin	1.3	1.7	5.4	-0.9	-0.2	1.1	0.0	0.5	1.9	1.5	2.1	1.0	-0.9	2.3	0.5
Supplements: Vitamin C	1.6	1.9	3.5	0.8	1.4	0.8	1.5	-1.7	1.9	-1.0	-0.6	-1.4	-1.9	1.1	-1.7
Knee pain experienced in last month	0.3	0.4	1.1	-0.5	-0.4	-0.1	-1.1	0.3	-0.0	0.9	0.9	0.8	0.1	0.7	0.3
Hypertension (Self-reported)	1.1	2.9	8.2	-2.1	-1.0	0.7	-0.8	1.4	1.1	2.7	2.9	2.0	-0.0	2.0	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.4	-1.4	-1.7	-0.7	-1.9	1.5	-1.5	1.5	0.9	1.6	1.7	-0.6	1.6
Illnesses of father: Heart disease	0.8	1.1	7.3	-0.2	0.6	2.7	0.5	0.1	1.1	0.8	1.0	0.2	-0.8	1.3	0.2
Illnesses of siblings: Diabetes	0.8	1.0	3.2	0.5	1.0	1.2	1.3	-0.6	1.8	-0.1	0.2	-0.7	-1.3	1.1	-0.7
Smoking status: Previous	2.2	3.3	6.4	2.0	2.0	0.7	2.5	-2.2	1.2	-1.9	-1.4	-2.3	-1.8	0.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	8.7	2.9	2.5	-0.5	2.2	-2.8	1.4	-2.8	-2.0	-2.7	-1.8	0.5	-2.9
Whole body fat-free mass	0.4	2.3	3.8	1.3	1.9	-1.4	1.6	-1.7	1.0	-1.7	-1.5	-1.8	-1.4	0.2	-1.9
Leg fat-free mass (right)	0.1	0.6	2.5	0.2	0.9	-1.6	0.6	-0.6	0.5	-0.5	-0.6	-0.7	-0.8	0.2	-0.9
Arm fat percentage (left)	1.7	6.9	12.2	-3.0	-2.7	-0.2	-2.7	3.3	-1.4	3.5	2.9	3.4	2.2	0.2	3.1
Average weekly red wine intake	4.3	6.4	12.0	2.6	2.8	0.8	3.2	-2.5	1.0	-3.5	-3.1	-3.3	-1.6	-0.9	-2.7
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	-0.3	0.3	0.0	0.4	0.1	-0.5	-0.7	-0.6	-0.4	0.2	-0.7	-0.1
Mood swings	1.1	2.0	6.4	2.5	1.1	-1.2	0.0	-1.9	-0.1	-1.6	-1.7	-1.5	-0.7	-0.2	-1.9
Loneliness, isolation	2.7	3.7	5.8	2.3	2.2	-0.8	2.0	-2.4	1.4	-2.4	-1.6	-2.4	-1.5	0.5	-2.4
Long-standing illness, disability or infirmity	0.9	1.3	4.6	-0.6	-0.2	-0.1	-0.8	-0.0	1.1	1.6	2.1	0.9	-0.8	2.1	0.2
Ever had bowel cancer screening	0.1	0.2	0.4	0.5	0.3	-0.6	0.0	-0.4	0.5	-0.1	-0.4	-0.3	-0.5	-0.0	-0.3
Diabetes diagnosed by doctor	0.9	1.4	3.1	1.2	1.4	1.6	1.8	-0.8	1.5	-0.7	-0.5	-1.2	-1.4	0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	0.9	0.6	0.0	0.2	-1.1	0.5	-1.3	-0.7	-1.1	-0.3	0.2	-1.2
Friendships satisfaction	1.1	1.3	3.0	1.1	1.3	0.6	1.0	-1.3	0.3	-1.1	-1.7	-1.4	-1.0	-1.0	-1.2
Qualifications: nursing, teaching	3.6	5.6	9.1	2.6	2.5	-0.8	2.6	-2.9	1.6	-3.0	-2.3	-3.0	-2.1	0.1	-2.8
Commuting to job workplace: Walk	7.9	8.5	15.6	3.1	3.3	0.2	2.7	-3.7	3.4	-2.3	-1.4	-3.0	-3.5	2.2	-3.9
Eye problems/disorders: Cataract	0.4	0.4	1.9	0.3	0.4	0.4	0.1	-0.4	0.9	0.6	0.9	0.1	-0.7	1.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	14.6	0.7	1.7	3.8	1.9	-1.2	2.5	-0.2	0.8	-0.9	-2.1	2.3	-1.2
Medication for cholesterol	0.3	0.5	1.2	0.8	0.5	0.3	0.6	-1.1	0.2	-1.0	-0.7	-0.9	-0.7	-0.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	7.7	-2.1	-2.0	1.7	-1.8	2.0	-0.2	2.8	2.6	2.5	1.1	1.0	2.2
Back pain experienced in last month	0.5	0.7	3.8	1.1	-0.2	-1.9	-0.3	-0.6	-0.7	-0.9	-0.7	-0.5	0.5	-0.6	-0.5
Mineral and other dietary supplements	2.5	3.3	6.3	-1.8	-2.0	-1.2	-2.4	1.9	-2.4	1.1	0.5	1.8	2.5	-1.4	1.8
Breast cancer (self-reported)	0.4	0.5	1.7	0.4	0.1	-0.9	-0.1	-0.0	-1.3	-0.7	-1.0	-0.4	0.5	-1.3	0.0
Asthma (self-reported)	0.1	0.2	0.6	0.5	0.8	-0.4	0.7	0.3	-0.2	-0.3	-0.7	-0.4	-0.1	-0.7	0.3
Osteoporosis (self-reported)	3.4	4.2	6.7	2.0	2.6	0.8	2.5	-2.2	0.9	-2.3	-2.5	-2.6	-2.0	-0.8	-2.1
Osteoarthritis (self-reported)	1.3	1.6	5.9	-1.2	-0.2	0.7	-0.6	0.2	1.5	1.7	2.2	1.0	-0.7	2.4	0.2
Medication: Aspirin	2.1	2.8	9.0	-1.2	-0.4	1.4	-0.1	0.6	2.2	2.1	2.8	1.3	-1.0	3.0	0.7
Medication: Gliclazide	2.0	2.3	4.6	-1.7	-1.2	2.1	-1.2	1.6	0.4	1.9	2.1	1.7	0.6	1.1	1.5
Illnesses of father: None of the above (group 1)	0.8	1.0	4.5	0.3	-0.0	-2.1	-0.3	-0.5	-1.2	-0.9	-1.3	-0.6	0.5	-1.4	-0.4
Smoking status: Current	0.3	0.5	1.0	-0.7	-0.8	0.5	-0.5	1.0	-0.2	0.9	0.8	1.0	0.7	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.0	-0.8	-1.1	1.4	-1.1	0.3	-0.2	0.3	0.9	0.7	0.7	0.4	0.3
Whole body water mass	0.4	2.4	3.9	1.3	2.0	-1.3	1.7	-1.7	1.1	-1.7	-1.5	-1.9	-1.5	0.2	-2.0
Leg predicted mass (right)	0.1	0.6	2.5	0.3	1.0	-1.6	0.6	-0.7	0.5	-0.5	-0.6	-0.7	-0.8	0.2	-0.9
Arm fat mass (left)	0.7	2.8	5.3	-2.0	-1.6	-0.5	-1.6	2.1	-0.7	2.3	1.9	2.1	1.3	0.4	1.9
Number of self-reported non-cancer illnesses	1.2	2.0	5.3	-0.5	0.8	2.2	0.9	-0.2	2.3	1.3	1.7	0.2	-1.7	2.3	-0.1
Average weekly champagne plus white wine intake	0.7	0.9	1.8	0.5	1.1	0.1	1.0	-1.1	1.2	-0.7	0.2	-0.8	-1.3	1.3	-1.1
Miserableness	0.7	1.2	2.2	1.2	1.1	-0.2	0.8	-1.3	1.5	-0.4	-0.1	-1.0	-1.4	1.3	-1.3
Guilty feelings	2.8	4.2	8.2	2.2	2.9	1.3	2.3	-2.2	2.3	-1.4	-0.9	-2.1	-2.6	1.4	-2.1
Wears glasses or contact lenses	0.5	0.6	0.9	0.9	1.0	0.5	0.7	-0.8	0.8	-0.9	-0.6	-0.9	-0.7	0.6	-0.8
Ever taken oral contraceptive pill	3.2	3.6	5.7	1.9	2.3	0.0	2.3	-2.4	2.1	-1.4	-0.6	-2.1	-2.3	1.4	-2.3
Hearing aid user	1.6	1.8	5.2	-0.9	-0.7	0.7	-1.5	1.1	0.4	2.2	2.3	1.7	0.2	1.7	1.0
Mother’s age at death	0.6	0.7	2.3	0.1	1.2	-0.6	1.5	-0.6	1.1	0.1	-0.2	-0.6	-1.5	0.3	-0.2
Financial situation satisfaction	0.0	0.1	0.2	0.4	-0.0	-0.1	-0.3	0.0	-0.2	-0.3	-0.2	-0.0	0.5	-0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.8	-0.9	-0.5	0.9	-1.3	0.4	0.2	1.1	1.4	0.8	0.1	1.1	0.4
Commuting to job workplace: Public transport	1.0	1.2	3.8	1.9	1.0	-0.7	1.5	-0.9	0.6	-1.3	-1.0	-1.3	-0.7	-0.1	-1.0
Eye problems/disorders: Glaucoma	1.1	1.3	2.9	-1.1	-0.8	0.7	-1.1	1.3	-0.1	1.6	1.7	1.5	0.6	0.9	1.2
Medication: Blood pressure	0.2	0.5	1.0	-0.9	-0.2	-0.3	-0.8	0.8	0.0	1.0	0.9	0.9	0.4	0.6	0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.7	5.2	0.0	-0.8	-2.3	-0.8	0.2	-0.5	0.6	0.7	0.5	0.5	0.5	0.1
Supplements: Fish oil (including cod liver oil)	2.7	3.6	7.5	1.7	2.1	1.2	2.4	-1.8	2.7	-1.0	-0.1	-1.6	-2.6	2.0	-1.9
High cholesterol (Self-reported)	0.0	0.1	0.4	0.3	0.0	-0.1	0.3	-0.0	0.6	-0.0	0.2	-0.1	-0.1	0.5	-0.2
Medication: Bendroflumethiazide	2.0	3.0	5.2	-1.8	-2.0	-1.9	-2.3	1.8	-1.2	1.9	1.4	2.1	1.6	-0.0	1.6
Medication: Paracetamol	0.8	1.2	2.2	-1.5	-1.2	1.1	-0.8	1.1	-0.2	1.2	1.5	1.3	0.8	0.5	1.0
Medication: Lisinopril	0.7	1.0	2.0	-0.8	-1.4	0.3	-1.4	0.8	-0.4	1.1	1.3	1.2	0.7	0.6	0.8
Medication: Atorvastatin	0.5	0.6	6.1	0.5	-0.4	-2.5	-0.5	-0.3	0.4	0.0	0.4	0.1	0.1	0.7	-0.2
Illnesses of father: High blood pressure	0.7	0.9	1.7	-1.2	-0.8	1.0	-0.5	1.3	0.2	1.1	1.0	1.1	0.7	0.2	1.1
Alcohol drinker status: Never	0.6	0.7	2.1	-0.6	-1.0	-1.3	-1.5	0.5	0.0	0.7	1.0	0.8	0.5	1.0	0.3
Ever smoked	0.7	1.2	2.7	0.9	0.5	0.2	1.3	-0.9	-0.6	-1.6	-1.6	-1.4	-0.0	-1.6	-0.8
Basal metabolic rate	0.2	1.3	2.0	0.8	1.4	-1.4	1.2	-1.2	0.7	-1.1	-1.1	-1.3	-1.0	0.1	-1.4
Leg fat percentage (left)	1.0	3.7	6.2	-2.0	-2.2	-0.8	-2.1	2.5	-1.6	2.1	1.6	2.2	2.2	-0.3	2.2
Arm fat-free mass (left)	0.3	1.3	2.1	0.9	1.4	-1.0	1.2	-1.2	1.0	-1.1	-0.9	-1.3	-1.2	0.5	-1.5
Number of operations (self-reported)	1.4	2.1	4.7	1.6	1.7	2.2	1.1	-1.5	1.6	-1.0	-0.4	-1.2	-1.6	1.3	-1.4
Average weekly beer plus cider intake	3.6	5.2	12.0	-1.8	-2.8	-1.9	-3.5	2.3	-2.1	2.2	1.5	2.7	2.6	-0.6	2.2
Irritability	0.4	0.7	2.3	1.5	0.4	-0.2	0.5	-0.9	-0.3	-1.3	-1.1	-1.0	-0.1	-0.3	-1.0
Risk taking	0.8	1.2	3.9	-0.4	-0.8	-0.7	-0.1	1.4	-1.5	-0.0	-0.7	0.4	1.6	-2.0	1.2
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.4	-1.7	-2.1	0.6	-1.7	1.7	-1.6	0.8	0.3	1.5	2.1	-1.2	1.6
Fractured/broken bones in last 5 years	0.3	0.4	1.3	0.7	0.4	1.2	0.9	-0.4	-0.1	-0.7	-0.6	-0.6	-0.2	-0.6	-0.3
Age started oral contraceptive pill	2.6	3.3	6.7	2.6	1.9	-0.8	1.5	-1.9	0.7	-2.6	-2.3	-2.2	-1.2	-0.3	-2.1
Diastolic blood pressure, automated reading	0.1	0.3	0.7	-0.3	-0.7	-0.5	-0.9	0.3	-0.7	-0.1	0.0	0.4	0.8	-0.2	0.0
Ever depressed for a whole week	0.2	0.2	0.6	-0.3	-0.7	-0.8	-0.7	-0.2	-0.1	0.2	0.3	0.3	0.4	0.2	-0.3
Unable to work because of sickness or disability	1.8	2.4	5.2	0.9	1.5	1.3	1.5	-1.7	2.3	-0.6	0.4	-1.1	-2.0	2.2	-1.6
Commuting to job workplace: Cycle	4.4	5.3	7.6	2.6	2.7	0.2	2.7	-2.7	2.2	-2.4	-1.8	-2.8	-2.6	0.5	-2.6
Myopia	1.9	2.7	5.3	1.8	2.3	-0.5	2.0	-1.9	1.5	-1.1	-1.0	-1.7	-2.3	0.8	-1.7
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.9	2.1	1.5	0.2	1.2	-1.6	-0.6	-2.4	-2.6	-2.0	-0.6	-1.6	-1.5
Cholesterol lowering medication	1.2	1.7	4.0	1.1	1.5	0.5	1.4	-1.4	2.0	-0.6	0.2	-1.2	-1.6	1.7	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	1.2	0.9	-0.2	0.4	-0.8	-0.2	-1.0	-1.2	-1.0	-0.3	-0.7	-0.8
Pain experienced in last month	1.3	2.2	5.4	0.5	1.6	2.3	1.9	-0.9	2.3	-0.4	-0.0	-1.0	-2.1	1.4	-1.0
Supplements: Calcium	2.1	2.4	5.3	1.1	1.6	2.3	1.9	-1.3	2.0	-0.3	0.5	-0.9	-2.1	1.8	-1.0
Basal cell carcinoma (self-reported)	1.4	1.6	3.6	1.6	1.1	0.6	0.9	-1.3	-0.1	-1.9	-1.9	-1.6	-0.5	-0.8	-1.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.3	-0.2	-0.5	-1.1	-0.6	0.1	0.1	0.2	0.4	0.3	0.3	0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	5.9	-1.8	-2.4	0.2	-1.7	2.3	-1.2	1.4	1.3	2.0	2.4	-0.5	2.1
Heart disease (siblings)	0.3	0.3	1.1	0.2	-0.7	0.0	-0.1	0.1	-0.9	-0.5	-0.7	-0.1	0.7	-1.1	0.2
Alcohol drinker status: Previous	0.5	0.5	4.8	-0.5	-0.1	2.2	0.5	0.2	0.5	0.4	0.5	0.2	-0.3	0.2	0.2
Pack years of smoking	2.1	3.1	5.7	-1.5	-1.9	-0.6	-2.4	1.9	-1.3	2.2	1.7	2.3	1.6	-0.2	2.0
Impedance of whole body	0.5	2.7	5.3	2.3	1.9	0.1	1.7	-2.1	0.6	-1.7	-1.6	-1.9	-1.7	-0.1	-1.8
Leg fat mass (left)	0.4	1.7	3.2	-1.5	-1.2	-1.0	-1.3	1.8	-0.8	1.6	1.2	1.6	1.2	0.1	1.4
Arm predicted mass (left)	0.2	1.1	1.9	0.8	1.4	-1.0	1.2	-1.0	0.8	-1.1	-1.0	-1.3	-1.0	0.2	-1.3