Best TWAS P=1.13e-23 · Best GWAS P=1.33e-41 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Colon Sigmoid | ABHD17AP6 | 0.15 | -0.01 | lasso | 6 | -0.01 | 6.9e-01 | -3.9 | -5.6 | 2.7e-08 | 0.20 | 0.03 | 0.10 | FALSE |
2 | GTEx | Colon Transverse | DHRS7B | 0.10 | 0.09 | lasso | 3 | 0.07 | 2.3e-04 | 4.3 | 5.2 | 2.6e-07 | -0.15 | 0.23 | 0.46 | TRUE |
3 | GTEx | Esophagus Mucosa | TMEM11 | 0.20 | 0.00 | lasso | 7 | 0.01 | 9.3e-02 | -4.6 | -5.6 | 2.1e-08 | 0.10 | 0.08 | 0.12 | TRUE |
4 | GTEx | Esophagus Muscularis | C17orf103 | 0.16 | 0.06 | lasso | 5 | 0.06 | 2.1e-04 | 6.9 | -7.2 | 7.0e-13 | 0.19 | 0.31 | 0.03 | FALSE |
5 | GTEx | Lung | C17orf103 | 0.08 | 0.01 | enet | 11 | 0.04 | 6.6e-04 | -7.7 | -9.6 | 1.3e-21 | 0.43 | 0.16 | 0.48 | TRUE |
6 | GTEx | Skin Sun Exposed Lower leg | C17orf103 | 0.11 | 0.02 | enet | 15 | 0.07 | 1.0e-06 | -4.6 | -8.7 | 3.2e-18 | 0.30 | 0.38 | 0.08 | TRUE |
7 | GTEx | Testis | C17orf103 | 0.15 | 0.21 | enet | 4 | 0.19 | 7.1e-09 | 6.8 | -7.6 | 2.5e-14 | 0.16 | 0.98 | 0.00 | TRUE |
8 | GTEx | Thyroid | DHRS7B | 0.17 | 0.02 | enet | 22 | 0.11 | 1.2e-08 | 4.3 | 8.7 | 4.9e-18 | -0.17 | 0.84 | 0.02 | FALSE |
9 | GTEx | Thyroid | KCNJ12 | 0.36 | 0.23 | lasso | 5 | 0.25 | 2.9e-19 | 8.8 | 10.0 | 1.1e-23 | -0.48 | 1.00 | 0.00 | TRUE |
10 | METSIM | Adipose | MAP2K3 | 0.08 | 0.02 | blup | 211 | 0.03 | 6.0e-05 | 6.4 | -6.5 | 6.4e-11 | 0.36 | 0.19 | 0.70 | FALSE |
11 | NTR | Blood | C17orf103 | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.6e-07 | 6.5 | -7.0 | 2.0e-12 | 0.14 | 0.98 | 0.00 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf103 | 0.03 | 0.04 | lasso | 1 | 0.04 | 7.9e-08 | 6.5 | -6.5 | 1.0e-10 | 0.12 | 0.98 | 0.02 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf103 | 0.05 | 0.04 | lasso | 3 | 0.02 | 5.4e-03 | 6.5 | -6.0 | 1.8e-09 | 0.11 | 0.05 | 0.18 | FALSE |
14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C17orf103 | 0.13 | 0.14 | lasso | 1 | 0.11 | 2.9e-05 | 6.5 | -6.5 | 1.0e-10 | 0.12 | 0.17 | 0.16 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf103 | 0.08 | 0.01 | blup | 44 | 0.01 | 3.2e-02 | 6.9 | -6.8 | 1.1e-11 | 0.29 | 0.03 | 0.54 | TRUE |