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chr17:16,718,225-18,923,818

Best TWAS P=1.45e-17 · Best GWAS P=1.5e-15 conditioned to 0.797

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
52	GTEx	Esophagus Gastroesophageal Junction	CTD-2303H24.2	0.33	0.20	lasso	3	0.34	6.0e-13	-6.75	8.5	1.5e-17	0.84	0.03	0.97	TRUE
6	GTEx	Adipose Subcutaneous	PEMT	0.17	0.13	enet	11	0.12	3.6e-10	4.09	5.3	9.5e-08	0.18	0.07	0.89	TRUE
116	The Cancer Genome Atlas	Breast Invasive Carcinoma	LLGL1	0.09	0.01	blup	52	0.02	1.1e-05	-4.72	-8.4	4.8e-17	-0.75	0.04	0.93	FALSE
100	GTEx	Whole Blood	CTD-2303H24.2	0.04	0.02	lasso	4	0.04	8.4e-05	7.69	8.4	5.3e-17	0.89	0.01	0.96	FALSE
169	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLII	0.05	0.04	blup	47	0.03	1.7e-03	7.64	-8.4	5.3e-17	-0.94	0.01	0.89	FALSE
12	GTEx	Adipose Visceral Omentum	CTD-2303H24.2	0.35	0.10	enet	14	0.23	2.8e-12	7.69	8.4	6.5e-17	0.80	0.01	0.99	FALSE
70	GTEx	Heart Left Ventricle	CTD-2303H24.2	0.24	0.04	lasso	6	0.10	4.3e-06	7.69	8.4	6.5e-17	0.83	0.01	0.98	FALSE
64	GTEx	Esophagus Muscularis	CTD-2303H24.2	0.25	0.09	lasso	5	0.16	8.4e-10	-6.75	8.3	1.1e-16	0.79	0.04	0.96	FALSE
83	GTEx	Skin Not Sun Exposed Suprapubic	CTD-2303H24.2	0.27	0.08	lasso	5	0.17	1.6e-09	6.66	8.3	1.1e-16	0.80	0.07	0.93	FALSE
109	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ALKBH5	0.05	0.02	lasso	2	0.03	3.1e-03	-6.88	-8.2	1.6e-16	-0.89	0.01	0.79	FALSE
59	GTEx	Esophagus Mucosa	CTD-2303H24.2	0.21	0.09	enet	29	0.17	2.4e-11	-6.75	8.2	2.1e-16	0.68	0.04	0.96	FALSE
88	GTEx	Small Intestine Terminal Ileum	CTD-2303H24.2	0.38	0.28	lasso	9	0.26	1.7e-06	7.98	8.2	3.0e-16	0.99	0.01	0.98	FALSE
110	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLII	0.04	0.02	blup	48	0.03	2.2e-03	7.98	-8.1	4.1e-16	-0.94	0.00	0.88	FALSE
149	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLII	0.03	0.01	lasso	4	0.00	8.4e-02	7.49	-8.1	4.8e-16	-0.91	0.01	0.43	FALSE
174	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ALKBH5	0.11	0.03	blup	64	0.04	1.8e-02	-5.10	-7.9	2.0e-15	-0.82	0.02	0.52	FALSE
129	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LLGL1	0.08	0.03	blup	52	0.05	1.9e-06	-5.11	-7.9	2.3e-15	-0.77	0.05	0.95	FALSE
94	GTEx	Testis	RP11-258F1.1	0.17	0.10	lasso	3	0.10	2.9e-05	-6.89	-7.9	2.8e-15	-0.79	0.03	0.95	FALSE
97	GTEx	Thyroid	CTD-2303H24.2	0.20	0.14	enet	8	0.13	1.9e-10	6.66	7.9	2.8e-15	0.67	0.66	0.34	FALSE
61	GTEx	Esophagus Muscularis	LLGL1	0.19	0.06	lasso	5	0.06	1.1e-04	7.67	7.9	3.6e-15	0.96	0.02	0.98	FALSE
30	GTEx	Brain Cortex	TOP3A	0.21	0.13	enet	11	0.09	1.8e-03	7.33	7.8	4.7e-15	0.81	0.04	0.74	FALSE
164	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMCR7	0.07	0.04	blup	33	0.03	3.0e-04	7.64	-7.8	4.7e-15	-0.86	0.01	0.96	FALSE
102	METSIM	Adipose	LGALS9C	0.07	0.06	lasso	6	0.05	6.5e-08	6.66	7.8	7.1e-15	0.70	0.36	0.64	FALSE
39	GTEx	Cells EBV-transformed lymphocytes	SHMT1	0.38	0.26	lasso	10	0.24	2.7e-08	6.67	-7.7	1.2e-14	-0.69	0.33	0.66	FALSE
32	GTEx	Brain Hippocampus	RP11-815I9.4	0.18	0.05	lasso	4	0.08	7.3e-03	7.66	7.7	1.7e-14	0.76	0.04	0.54	FALSE
124	The Cancer Genome Atlas	Colon Adenocarcinoma	ALKBH5	0.14	0.07	lasso	4	0.09	5.5e-06	-6.88	-7.7	1.7e-14	-0.76	0.26	0.74	FALSE
130	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SHMT1	0.12	0.06	blup	32	0.07	1.6e-08	6.77	-7.6	2.7e-14	-0.67	0.00	1.00	FALSE
50	GTEx	Esophagus Gastroesophageal Junction	SHMT1	0.15	0.00	lasso	4	0.00	2.5e-01	7.81	-7.6	3.2e-14	-0.85	0.02	0.77	FALSE
139	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO15A	0.04	0.02	lasso	3	0.02	2.5e-03	7.67	-7.6	3.2e-14	-0.92	0.02	0.81	FALSE
48	GTEx	Colon Transverse	TOP3A	0.11	0.04	lasso	5	0.07	3.5e-04	-7.00	7.6	3.3e-14	0.76	0.10	0.81	FALSE
33	GTEx	Breast Mammary Tissue	ALKBH5	0.07	0.09	enet	6	0.08	6.1e-05	-6.89	-7.5	4.3e-14	-0.68	0.09	0.74	FALSE
90	GTEx	Spleen	CTD-2303H24.2	0.32	0.02	enet	15	0.12	5.2e-04	7.69	7.5	5.6e-14	0.78	0.03	0.81	FALSE
168	The Cancer Genome Atlas	Stomach Adenocarcinoma	ALKBH5	0.07	0.05	blup	63	0.06	2.0e-05	-6.89	-7.5	6.3e-14	-0.78	0.08	0.87	FALSE
28	GTEx	Brain Cerebellum	TOP3A	0.22	0.09	lasso	5	0.15	3.0e-05	6.81	7.5	7.5e-14	0.67	0.08	0.87	FALSE
142	The Cancer Genome Atlas	Lung Adenocarcinoma	FLII	0.04	0.01	blup	47	0.03	5.1e-04	7.64	-7.4	1.1e-13	-0.86	0.01	0.93	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SHMT1	0.22	0.14	enet	16	0.17	5.5e-20	6.85	-7.4	1.2e-13	-0.61	0.94	0.06	FALSE
9	GTEx	Adipose Subcutaneous	CTD-2303H24.2	0.16	0.11	enet	15	0.18	2.4e-14	-6.75	7.4	1.3e-13	0.63	0.50	0.50	FALSE
49	GTEx	Colon Transverse	CTD-2303H24.2	0.08	0.08	lasso	4	0.04	5.9e-03	-6.75	7.4	1.6e-13	0.65	0.08	0.68	FALSE
117	The Cancer Genome Atlas	Breast Invasive Carcinoma	SHMT1	0.06	0.05	blup	33	0.05	8.2e-11	6.66	-7.4	1.7e-13	-0.61	0.01	0.99	FALSE
153	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMCR8	0.04	0.00	blup	33	0.00	2.0e-01	6.81	-7.4	1.8e-13	-0.72	0.00	0.42	FALSE
58	GTEx	Esophagus Mucosa	RP11-258F1.1	0.12	0.11	lasso	3	0.10	2.5e-07	-7.00	-7.3	2.1e-13	-0.62	0.72	0.25	FALSE
37	GTEx	Breast Mammary Tissue (Female)	ALKBH5	0.12	0.08	lasso	3	0.08	2.3e-03	-7.00	-7.3	2.3e-13	-0.68	0.05	0.70	FALSE
106	ROSMAP	Brain Pre-frontal Cortex	USP32P2	0.74	0.61	enet	18	0.65	4.4e-110	-6.75	7.3	2.9e-13	0.57	0.95	0.05	FALSE
111	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LLGL1	0.07	0.04	blup	53	0.03	6.6e-04	-4.72	-7.3	2.9e-13	-0.80	0.04	0.68	FALSE
81	GTEx	Nerve Tibial	CTD-2303H24.2	0.23	0.08	enet	15	0.18	9.4e-13	-6.75	7.3	3.2e-13	0.62	0.27	0.73	FALSE
158	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SHMT1	0.19	0.13	blup	40	0.11	3.1e-05	6.81	-7.3	3.2e-13	-0.71	0.00	0.98	FALSE
25	GTEx	Artery Tibial	CTD-2303H24.2	0.32	0.17	lasso	7	0.23	7.1e-18	6.66	7.2	4.4e-13	0.61	0.96	0.04	FALSE
66	GTEx	Heart Atrial Appendage	SHMT1	0.12	0.06	lasso	4	0.06	1.1e-03	6.72	-7.2	4.9e-13	-0.59	0.16	0.43	FALSE
133	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TOP3A	0.07	0.02	blup	48	0.02	1.3e-03	7.64	-7.2	5.4e-13	-0.83	0.00	0.97	FALSE
143	The Cancer Genome Atlas	Lung Adenocarcinoma	LLGL1	0.05	0.02	enet	6	0.03	7.1e-05	-5.10	-7.2	5.7e-13	-0.83	0.03	0.88	FALSE
72	GTEx	Lung	CTD-2303H24.2	0.45	0.12	lasso	6	0.27	1.3e-20	6.66	7.2	6.6e-13	0.58	0.90	0.10	FALSE
43	GTEx	Cells Transformed fibroblasts	CTD-2303H24.2	0.29	0.10	lasso	3	0.12	5.8e-09	6.66	7.2	8.6e-13	0.56	0.96	0.04	FALSE
16	GTEx	Artery Aorta	SHMT1	0.35	0.20	enet	23	0.31	1.3e-17	-4.69	-7.2	8.8e-13	-0.55	0.97	0.03	FALSE
87	GTEx	Small Intestine Terminal Ileum	TOP3A	0.25	0.09	lasso	5	0.06	1.8e-02	7.66	7.2	8.8e-13	0.65	0.06	0.46	FALSE
36	GTEx	Breast Mammary Tissue (Male)	CTD-2303H24.2	0.27	0.00	enet	33	0.01	1.5e-01	6.66	7.1	1.0e-12	0.62	0.04	0.23	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC144B	0.21	0.05	enet	30	0.16	1.5e-18	6.72	7.1	1.1e-12	0.63	0.08	0.92	FALSE
46	GTEx	Colon Sigmoid	CTD-2303H24.2	0.55	0.33	enet	37	0.30	4.2e-11	-6.75	7.1	1.1e-12	0.54	0.91	0.08	FALSE
131	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR7	0.07	0.02	lasso	3	0.01	8.3e-03	-4.96	-7.1	1.1e-12	-0.82	0.01	0.78	FALSE
78	GTEx	Nerve Tibial	SHMT1	0.30	0.20	lasso	6	0.29	5.5e-21	-4.69	-7.1	1.2e-12	-0.60	0.98	0.02	FALSE
104	METSIM	Adipose	SHMT1	0.12	0.02	bslmm	259	0.03	5.4e-05	6.66	-7.1	1.2e-12	-0.44	0.45	0.41	FALSE
105	ROSMAP	Brain Pre-frontal Cortex	TOP3A	0.15	0.09	lasso	7	0.14	2.8e-17	7.72	7.1	1.3e-12	0.64	0.05	0.95	FALSE
146	The Cancer Genome Atlas	Lung Adenocarcinoma	SMCR8	0.06	0.01	enet	9	0.03	3.3e-04	-3.65	-7.1	1.3e-12	-0.68	0.01	0.72	FALSE
65	GTEx	Heart Atrial Appendage	TOM1L2	0.12	0.04	enet	2	0.04	7.0e-03	7.05	-7.1	1.5e-12	-0.76	0.05	0.83	FALSE
68	GTEx	Heart Atrial Appendage	CTD-2303H24.2	0.26	0.11	lasso	6	0.13	1.5e-06	-6.75	7.0	1.7e-12	0.67	0.02	0.96	FALSE
148	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALKBH5	0.02	0.02	blup	63	0.01	3.4e-02	-6.88	-7.0	1.7e-12	-0.67	0.08	0.38	FALSE
82	GTEx	Pituitary	CTD-2303H24.2	0.27	0.04	lasso	8	0.08	4.1e-03	6.66	7.0	1.9e-12	0.67	0.04	0.40	FALSE
22	GTEx	Artery Tibial	ALKBH5	0.17	0.16	lasso	5	0.15	4.8e-12	-7.00	-7.0	2.0e-12	-0.65	0.79	0.21	FALSE
74	GTEx	Muscle Skeletal	SHMT1	0.16	0.08	lasso	5	0.13	1.0e-12	6.85	-7.0	2.3e-12	-0.58	0.87	0.13	FALSE
101	METSIM	Adipose	FAM106A	0.20	0.13	enet	21	0.15	5.8e-22	6.85	7.0	2.4e-12	0.56	0.94	0.06	FALSE
144	The Cancer Genome Atlas	Lung Adenocarcinoma	SHMT1	0.04	0.05	lasso	3	0.04	9.2e-06	6.72	-7.0	2.4e-12	-0.55	0.01	0.99	FALSE
162	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLII	0.08	0.02	enet	6	0.04	1.9e-05	-3.57	-7.0	2.5e-12	-0.71	0.04	0.69	FALSE
159	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMCR7	0.13	0.05	enet	11	0.08	4.3e-04	-3.65	-7.0	2.6e-12	-0.67	0.02	0.67	FALSE
95	GTEx	Testis	CTD-2303H24.2	0.50	0.26	lasso	17	0.36	1.1e-16	-6.75	7.0	2.9e-12	0.60	0.51	0.49	FALSE
152	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SHMT1	0.07	0.03	enet	6	0.05	2.5e-06	6.85	-7.0	3.2e-12	-0.56	0.00	1.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MYO15A	0.17	0.12	bslmm	313	0.14	4.5e-16	7.77	-7.0	3.5e-12	-0.77	0.01	0.99	FALSE
18	GTEx	Artery Aorta	RP11-258F1.1	0.11	0.12	lasso	5	0.10	4.7e-06	-7.00	-6.9	3.8e-12	-0.62	0.51	0.42	FALSE
60	GTEx	Esophagus Muscularis	ALKBH5	0.12	0.16	lasso	2	0.14	7.3e-09	-7.00	-7.0	3.8e-12	-0.62	0.82	0.18	FALSE
161	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALKBH5	0.19	0.02	blup	63	0.04	3.4e-05	7.98	-7.0	3.8e-12	-0.78	0.01	0.98	FALSE
63	GTEx	Esophagus Muscularis	RP11-258F1.1	0.19	0.17	lasso	6	0.13	3.1e-08	-7.00	-6.9	3.9e-12	-0.63	0.83	0.17	FALSE
34	GTEx	Breast Mammary Tissue	CTD-2303H24.2	0.32	0.07	enet	34	0.15	5.3e-08	6.66	6.9	4.3e-12	0.61	0.33	0.50	FALSE
85	GTEx	Skin Sun Exposed Lower leg	RP11-258F1.1	0.12	0.10	lasso	5	0.09	9.9e-08	-6.89	-6.9	4.4e-12	-0.61	0.75	0.25	FALSE
84	GTEx	Skin Sun Exposed Lower leg	ALKBH5	0.16	0.14	lasso	3	0.13	1.0e-10	-6.89	-6.9	4.6e-12	-0.62	0.83	0.17	FALSE
86	GTEx	Skin Sun Exposed Lower leg	CTD-2303H24.2	0.24	0.08	enet	20	0.13	3.9e-11	6.66	6.9	4.7e-12	0.61	0.79	0.21	FALSE
24	GTEx	Artery Tibial	RP11-258F1.1	0.18	0.15	lasso	3	0.15	1.6e-11	-6.89	-6.9	5.2e-12	-0.61	0.82	0.18	FALSE
8	GTEx	Adipose Subcutaneous	RP11-258F1.1	0.19	0.13	lasso	4	0.12	3.6e-10	-6.89	-6.9	5.4e-12	-0.64	0.82	0.18	FALSE
80	GTEx	Nerve Tibial	RP11-258F1.1	0.16	0.15	lasso	1	0.15	7.5e-11	-6.89	-6.9	5.5e-12	-0.62	0.79	0.21	FALSE
171	The Cancer Genome Atlas	Stomach Adenocarcinoma	SHMT1	0.17	0.10	lasso	2	0.08	1.0e-06	6.75	-6.9	6.2e-12	-0.63	0.01	0.99	FALSE
19	GTEx	Artery Aorta	CTD-2303H24.2	0.39	0.12	enet	37	0.27	3.7e-15	-6.75	6.9	6.4e-12	0.57	0.02	0.98	FALSE
128	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALKBH5	0.02	0.02	enet	4	0.02	3.9e-03	-6.87	-6.9	6.6e-12	-0.61	0.05	0.31	FALSE
5	GTEx	Adipose Subcutaneous	ALKBH5	0.19	0.18	lasso	2	0.17	1.0e-13	-6.89	-6.9	6.8e-12	-0.61	0.84	0.16	FALSE
62	GTEx	Esophagus Muscularis	SHMT1	0.28	0.21	lasso	5	0.34	2.3e-21	6.85	-6.9	6.8e-12	-0.54	0.90	0.10	FALSE
77	GTEx	Nerve Tibial	ALKBH5	0.27	0.19	lasso	3	0.16	1.1e-11	-6.80	-6.9	6.9e-12	-0.61	0.85	0.15	FALSE
166	The Cancer Genome Atlas	Soft Tissue Sarcoma	SHMT1	0.07	0.06	lasso	5	0.05	5.5e-04	6.75	-6.8	7.4e-12	-0.63	0.01	0.95	FALSE
75	GTEx	Muscle Skeletal	RP11-258F1.1	0.09	0.10	lasso	2	0.09	2.2e-09	-6.80	-6.8	7.5e-12	-0.61	0.86	0.14	FALSE
156	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALKBH5	0.22	0.10	blup	66	0.12	1.4e-05	7.67	-6.8	7.5e-12	-0.72	0.02	0.87	FALSE
98	GTEx	Vagina	SHMT1	0.38	0.02	lasso	4	-0.01	6.6e-01	7.69	6.8	7.6e-12	0.90	0.01	0.75	FALSE
15	GTEx	Artery Aorta	ALKBH5	0.08	0.05	lasso	7	0.06	5.2e-04	-4.69	-6.8	9.2e-12	-0.64	0.11	0.73	FALSE
11	GTEx	Adipose Visceral Omentum	RP11-258F1.1	0.08	0.02	lasso	2	0.03	1.3e-02	-6.80	-6.8	1.1e-11	-0.61	0.18	0.22	FALSE
51	GTEx	Esophagus Gastroesophageal Junction	RP11-258F1.1	0.34	0.12	lasso	1	0.10	1.6e-04	-6.80	-6.8	1.1e-11	-0.61	0.23	0.26	FALSE
92	GTEx	Stomach	RP11-258F1.1	0.13	0.12	lasso	1	0.10	2.4e-05	-6.80	-6.8	1.1e-11	-0.61	0.60	0.33	FALSE
115	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLII	0.04	0.01	blup	47	0.02	7.2e-05	7.64	-6.8	1.2e-11	-0.77	0.01	0.89	FALSE
47	GTEx	Colon Transverse	ALKBH5	0.16	0.08	lasso	4	0.07	3.4e-04	-6.87	-6.8	1.3e-11	-0.59	0.20	0.41	FALSE
112	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SHMT1	0.06	0.07	lasso	2	0.06	8.3e-06	6.75	-6.8	1.3e-11	-0.62	0.01	0.99	FALSE
155	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SHMT1	0.12	0.08	enet	5	0.07	8.8e-04	6.77	-6.8	1.3e-11	-0.58	0.01	0.82	FALSE
69	GTEx	Heart Left Ventricle	RP11-258F1.1	0.09	0.06	lasso	2	0.04	2.4e-03	-6.80	-6.7	1.6e-11	-0.61	0.17	0.54	FALSE
76	GTEx	Muscle Skeletal	CTD-2303H24.2	0.23	0.11	enet	23	0.17	5.2e-16	-6.75	6.7	1.7e-11	0.57	0.32	0.68	FALSE
120	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOP3A	0.05	0.02	enet	8	0.03	1.2e-07	-3.62	-6.7	1.8e-11	-0.70	0.02	0.98	FALSE
132	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR8	0.10	0.02	blup	33	0.03	8.1e-05	-4.95	-6.7	1.9e-11	-0.67	0.03	0.46	FALSE
73	GTEx	Muscle Skeletal	ALKBH5	0.10	0.09	lasso	3	0.07	2.0e-07	-6.89	-6.7	2.1e-11	-0.61	0.86	0.14	FALSE
41	GTEx	Cells Transformed fibroblasts	SHMT1	0.42	0.27	lasso	7	0.39	2.7e-31	-4.69	-6.7	2.3e-11	-0.56	1.00	0.00	FALSE
23	GTEx	Artery Tibial	SHMT1	0.49	0.29	lasso	6	0.44	4.0e-38	-4.69	-6.7	2.4e-11	-0.52	0.96	0.04	FALSE
114	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALKBH5	0.06	0.02	blup	63	0.02	7.2e-06	2.14	-6.7	2.8e-11	-0.61	0.05	0.80	FALSE
134	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALKBH5	0.05	0.05	lasso	3	0.04	1.7e-05	-6.79	-6.7	2.8e-11	-0.60	0.66	0.19	FALSE
140	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SHMT1	0.20	0.18	lasso	5	0.16	3.2e-08	6.77	-6.7	2.9e-11	-0.60	0.00	1.00	FALSE
91	GTEx	Stomach	SHMT1	0.21	0.05	enet	18	0.08	1.4e-04	-4.69	-6.6	3.4e-11	-0.51	0.55	0.34	FALSE
57	GTEx	Esophagus Mucosa	TOP3A	0.08	0.04	enet	10	0.05	4.1e-04	5.52	6.6	4.3e-11	0.52	0.12	0.72	FALSE
141	The Cancer Genome Atlas	Lung Adenocarcinoma	ALKBH5	0.09	0.02	lasso	3	0.03	1.2e-04	7.64	-6.6	4.6e-11	-0.84	0.01	0.96	FALSE
121	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALKBH5	0.07	0.05	blup	63	0.05	2.1e-03	-5.10	-6.6	4.9e-11	-0.58	0.04	0.29	FALSE
125	The Cancer Genome Atlas	Colon Adenocarcinoma	LLGL1	0.14	0.13	enet	8	0.14	3.2e-08	-5.10	-6.5	6.4e-11	-0.70	0.86	0.11	FALSE
21	GTEx	Artery Coronary	CTD-2303H24.2	0.38	0.04	lasso	7	0.20	3.8e-07	6.66	6.5	7.9e-11	0.58	0.06	0.86	FALSE
165	The Cancer Genome Atlas	Rectum Adenocarcinoma	SHMT1	0.49	0.16	lasso	5	0.11	1.9e-03	6.85	-6.5	8.9e-11	-0.44	0.00	0.71	FALSE
42	GTEx	Cells Transformed fibroblasts	RP11-258F1.1	0.18	0.12	lasso	3	0.15	1.7e-11	-7.00	-6.5	1.0e-10	-0.63	0.80	0.20	FALSE
79	GTEx	Nerve Tibial	TOP3A	0.35	0.21	lasso	12	0.18	1.1e-12	6.67	6.5	1.1e-10	0.56	0.96	0.04	FALSE
7	GTEx	Adipose Subcutaneous	SHMT1	0.20	0.07	lasso	9	0.04	1.4e-04	6.77	-6.4	1.3e-10	-0.59	0.51	0.38	FALSE
123	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMCR7	0.19	0.03	blup	33	0.06	4.5e-04	1.38	-6.4	1.4e-10	-0.71	0.01	0.75	FALSE
176	The Cancer Genome Atlas	Thyroid Carcinoma	ALKBH5	0.09	0.06	lasso	2	0.06	2.9e-06	-6.87	-6.4	1.4e-10	-0.55	0.83	0.11	FALSE
177	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SMCR8	0.60	0.03	blup	43	0.02	9.3e-02	1.46	-6.4	2.0e-10	-0.57	0.01	0.10	FALSE
163	The Cancer Genome Atlas	Prostate Adenocarcinoma	LLGL1	0.10	0.04	lasso	7	0.04	7.5e-05	-4.96	-6.3	2.3e-10	-0.63	0.24	0.66	FALSE
151	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYO15A	0.03	0.02	blup	79	0.02	9.4e-04	7.39	-6.3	2.5e-10	-0.82	0.02	0.72	FALSE
145	The Cancer Genome Atlas	Lung Adenocarcinoma	SMCR7	0.05	0.03	enet	7	0.05	3.7e-06	7.69	-6.3	2.8e-10	-0.77	0.01	0.98	FALSE
113	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TOP3A	0.05	0.01	blup	53	0.02	1.0e-02	-3.18	-6.2	4.3e-10	-0.67	0.06	0.20	FALSE
122	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SHMT1	0.11	0.05	lasso	3	0.04	4.0e-03	-4.69	-6.2	4.3e-10	-0.53	0.01	0.64	FALSE
107	YFS	Blood	SHMT1	0.46	0.28	bslmm	255	0.41	7.3e-145	6.67	-6.2	4.8e-10	-0.47	0.95	0.05	FALSE
71	GTEx	Lung	SHMT1	0.15	0.13	lasso	6	0.16	2.4e-12	-3.34	-6.2	5.9e-10	-0.49	0.94	0.06	FALSE
108	YFS	Blood	TOP3A	0.04	0.02	enet	20	0.03	9.3e-10	7.69	6.2	6.0e-10	0.77	0.01	0.99	FALSE
136	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMCR7	0.04	0.01	blup	34	0.02	1.0e-03	-3.46	-6.2	6.1e-10	-0.69	0.06	0.39	FALSE
157	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLII	0.20	0.08	blup	54	0.13	7.0e-06	6.75	-6.1	1.1e-09	-0.74	0.04	0.65	FALSE
170	The Cancer Genome Atlas	Stomach Adenocarcinoma	LLGL1	0.09	0.06	enet	6	0.05	2.5e-04	-4.72	-6.1	1.1e-09	-0.57	0.18	0.36	FALSE
150	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LLGL1	0.09	0.02	blup	52	0.04	4.9e-05	-3.34	-6.1	1.2e-09	-0.60	0.22	0.68	FALSE
31	GTEx	Brain Cortex	CTD-2303H24.2	0.34	0.08	enet	42	0.15	5.3e-05	6.85	6.1	1.3e-09	0.49	0.06	0.46	FALSE
38	GTEx	Breast Mammary Tissue (Female)	CTD-2303H24.2	0.41	0.02	enet	30	0.14	7.5e-05	-6.75	6.1	1.3e-09	0.52	0.08	0.26	FALSE
17	GTEx	Artery Aorta	TOP3A	0.13	0.11	enet	8	0.15	1.8e-08	-4.72	6.0	1.5e-09	0.55	0.87	0.12	FALSE
99	GTEx	Whole Blood	CCDC144B	0.05	0.06	lasso	2	0.06	3.2e-06	-4.68	-6.0	1.5e-09	-0.47	0.36	0.21	FALSE
35	GTEx	Breast Mammary Tissue (Male)	TOP3A	0.24	0.12	enet	25	0.19	2.9e-05	-4.72	6.0	1.7e-09	0.42	0.05	0.06	FALSE
29	GTEx	Brain Cerebellum	CTD-2303H24.2	0.46	0.15	lasso	5	0.12	2.8e-04	6.66	6.0	2.1e-09	0.49	0.11	0.25	FALSE
160	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMCR8	0.12	0.00	blup	43	0.06	2.0e-03	6.75	-6.0	2.1e-09	-0.57	0.00	0.28	FALSE
67	GTEx	Heart Atrial Appendage	AC122129.1	0.15	0.02	enet	9	0.08	1.4e-04	7.43	-6.0	2.3e-09	-0.64	0.06	0.80	FALSE
137	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLII	0.16	0.00	enet	6	0.06	1.4e-04	1.46	-6.0	2.5e-09	-0.64	0.02	0.41	FALSE
119	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMCR8	0.02	0.01	blup	34	0.01	1.5e-02	1.38	-6.0	2.7e-09	-0.61	0.01	0.05	FALSE
40	GTEx	Cells Transformed fibroblasts	ALKBH5	0.16	0.05	lasso	7	0.10	9.2e-08	-7.00	-5.9	2.8e-09	-0.60	0.84	0.15	FALSE
14	GTEx	Adrenal Gland	CTD-2303H24.2	0.31	0.05	lasso	7	0.12	3.6e-05	1.48	5.9	3.5e-09	0.67	0.07	0.76	FALSE
27	GTEx	Brain Cerebellar Hemisphere	CTD-2303H24.2	0.53	0.08	enet	50	0.15	1.4e-04	6.66	5.9	3.8e-09	0.54	0.11	0.46	FALSE
154	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOP3A	0.08	0.00	blup	48	0.01	1.6e-02	-3.57	-5.9	3.9e-09	-0.53	0.02	0.11	FALSE
172	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMCR7	0.06	0.02	enet	7	0.04	9.1e-04	-4.51	-5.9	3.9e-09	-0.67	0.01	0.65	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM106A	0.05	0.01	bslmm	278	0.02	8.6e-04	1.38	5.8	5.4e-09	0.48	0.08	0.30	FALSE
10	GTEx	Adipose Visceral Omentum	TRIM16L	0.19	0.00	enet	27	0.06	7.4e-04	-0.75	-5.8	6.5e-09	-0.46	0.09	0.40	FALSE
96	GTEx	Thyroid	TOP3A	0.14	0.08	lasso	3	0.09	1.5e-07	-3.34	5.8	7.5e-09	0.53	0.18	0.82	FALSE
118	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMCR7	0.06	0.00	enet	7	0.02	1.5e-05	1.38	-5.7	1.1e-08	-0.60	0.02	0.66	FALSE
26	GTEx	Brain Caudate basal ganglia	ALKBH5	0.12	0.00	lasso	6	0.03	4.4e-02	3.50	-5.7	1.3e-08	-0.41	0.19	0.10	FALSE
93	GTEx	Testis	SHMT1	0.28	0.05	enet	20	0.12	7.6e-06	-3.31	5.7	1.3e-08	0.43	0.12	0.11	FALSE
53	GTEx	Esophagus Mucosa	ALKBH5	0.09	0.08	lasso	8	0.06	9.3e-05	-7.00	-5.6	1.7e-08	-0.49	0.40	0.16	FALSE
89	GTEx	Spleen	TOP3A	0.33	0.16	lasso	6	0.21	5.1e-06	-4.51	5.6	1.7e-08	0.53	0.43	0.18	FALSE
13	GTEx	Adrenal Gland	SHMT1	0.57	0.25	enet	25	0.33	9.9e-13	-3.34	-5.6	1.8e-08	-0.45	0.43	0.54	FALSE
45	GTEx	Colon Sigmoid	RP11-258F1.1	0.09	0.01	lasso	13	0.00	2.1e-01	-6.89	-5.6	2.1e-08	-0.43	0.10	0.05	FALSE
56	GTEx	Esophagus Mucosa	SHMT1	0.25	0.03	enet	49	0.06	1.3e-04	7.57	-5.6	2.5e-08	-0.46	0.04	0.88	FALSE
127	The Cancer Genome Atlas	Colon Adenocarcinoma	SMCR8	0.09	0.00	enet	13	0.04	2.3e-03	-4.51	-5.5	4.3e-08	-0.50	0.01	0.36	FALSE
44	GTEx	Colon Sigmoid	TOP3A	0.51	0.08	lasso	15	0.16	2.9e-06	6.75	5.5	4.9e-08	0.38	0.26	0.28	FALSE
147	The Cancer Genome Atlas	Lung Adenocarcinoma	TOP3A	0.08	0.04	enet	8	0.07	3.7e-08	-3.18	-5.4	5.3e-08	-0.68	0.11	0.89	FALSE
175	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYO15A	0.21	0.01	blup	78	0.01	1.1e-01	7.98	-5.4	7.6e-08	-0.68	0.01	0.57	FALSE
138	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TOP3A	0.11	0.01	enet	10	0.05	5.8e-04	7.64	-5.3	8.7e-08	-0.70	0.01	0.76	FALSE
20	GTEx	Artery Coronary	CCDC144B	0.14	0.02	lasso	5	0.02	5.2e-02	5.52	-5.3	1.1e-07	-0.44	0.08	0.20	FALSE
173	The Cancer Genome Atlas	Stomach Adenocarcinoma	TOP3A	0.09	0.06	blup	48	0.05	1.8e-04	-3.57	-5.3	1.1e-07	-0.62	0.31	0.44	FALSE
126	The Cancer Genome Atlas	Colon Adenocarcinoma	SHMT1	0.08	0.06	enet	9	0.06	1.6e-04	-4.69	-5.3	1.4e-07	-0.44	0.56	0.25	FALSE
54	GTEx	Esophagus Mucosa	DRG2	0.06	0.00	enet	19	0.01	1.3e-01	4.29	-5.2	1.5e-07	-0.37	0.12	0.05	FALSE
103	METSIM	Adipose	PEMT	0.13	0.09	lasso	8	0.11	2.6e-16	3.78	5.2	1.6e-07	0.20	0.22	0.65	FALSE
135	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVPLL	0.04	0.00	blup	22	0.00	2.8e-01	6.85	5.2	1.7e-07	0.53	0.00	0.64	FALSE
55	GTEx	Esophagus Mucosa	LLGL1	0.38	0.39	lasso	6	0.39	8.0e-28	-5.11	-5.2	2.3e-07	-0.55	1.00	0.00	FALSE
167	The Cancer Genome Atlas	Soft Tissue Sarcoma	TOP3A	0.08	0.03	enet	24	0.04	1.6e-03	-3.62	-5.2	2.6e-07	-0.70	0.02	0.79	FALSE