Hub : Genes

MTIF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1478	0.0513	0.00067	0.014	NA	0.020	NA	0.020	0.026	NA	0.00980	NA	0.0110
2	GTEx	Nerve Tibial	0.1145	0.0464	0.00470	0.006	NA	0.040	NA	0.026	0.110	NA	0.00081	NA	0.0059
3	GTEx	Testis	0.1270	0.0540	0.00650	0.006	NA	0.013	NA	0.009	0.160	NA	0.08500	NA	0.1200
4	YFS	Blood	0.0223	0.0096	0.00410	0.000	0.002	0.002	0.004	0.000	0.250	0.046	0.06200	0.013	0.2800

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	1.3	-0.2	-1.2	-1.1	-0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	3.5	-0.9	-1.9	-0.7	0.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.6	-0.9	-1.3	-0.8	-0.8
Depression (Nagel 2018)	0.5	0.8	1.9	-0.1	-0.8	-1.4	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.9	-0.4	-0.6	1.7	-0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.6	-0.4	0.3	-0.4
Schizophrenia (2018)	0.4	0.9	2.2	-1.0	-1.5	0.1	0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	0.8	-0.1	1.3	-0.5
Worry (Nagel 2018)	0.5	1.1	2.6	1.6	0.5	1.2	-0.4
Alzheimer’s Disease (in mother)	1.2	1.4	2.4	1.0	1.6	0.4	1.4
Alzheimer’s Disease (in father)	1.1	1.2	1.8	1.1	-1.1	-1.3	0.8
Alzheimer’s Disease (including proxy)	1.5	2.2	4.2	1.8	1.0	-0.5	2.0
Crohns Disease (2017)	0.3	0.6	1.6	-0.3	-0.9	-0.2	-1.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	0.4	-0.5	-0.4	-0.3
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.6	0.2	-0.9	0.7
Major Depression (MDD)	1.1	1.3	3.4	-0.6	-1.9	1.1	0.4
Reaction Time	0.4	0.7	1.9	0.6	-0.4	0.6	-1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.7	0.3	-0.2	1.6	-0.6
Breast Cancer	0.4	1.1	2.0	0.0	1.4	1.4	0.7
Ovarian Cancer	1.5	2.0	5.2	0.2	1.6	-0.4	2.3
Prostate Cancer	0.5	0.8	2.4	0.6	-0.3	1.6	0.4
Age at First Birth	0.9	1.4	3.2	1.1	0.9	1.8	-0.4
Bipolar Disorder (2011)	0.3	0.3	1.1	-0.3	-1.0	-0.1	-0.4
Body Mass Index (BMI) (2010)	1.0	1.4	3.1	-1.3	0.8	0.5	-1.8
Coronary Artery Disease (CAD)	1.0	1.2	3.4	-1.9	0.4	-0.6	1.0
Crohns Disease (2012)	0.4	0.6	2.0	-0.0	-0.5	0.4	-1.4
Mean Putamen Volume	0.7	0.8	2.4	0.5	-0.4	-0.7	-1.6
Fasting Glucose	1.1	1.4	2.4	-0.7	-1.5	-1.5	-0.6
HbA1C	0.5	0.6	1.5	-0.9	-1.2	0.2	0.1
HDL Cholesterol	0.3	0.5	1.0	-0.2	-0.5	-0.9	-1.0
LDL Cholesterol	0.6	1.0	2.7	-0.5	-0.7	-1.6	0.6
Lupus	0.7	1.0	3.1	-0.2	0.7	1.8	-0.7
Neuroticism (2016)	0.3	0.4	1.5	0.1	-1.2	0.1	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.4	-1.2	0.1	-0.6	1.0
Rheumatoid Arthritis	1.9	2.6	8.5	-2.9	-0.9	-0.0	-1.0
Schizophrenia (2014)	0.5	1.1	2.7	-1.3	-1.6	0.1	0.5
Triglycerides	0.1	0.2	0.4	-0.0	0.3	-0.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	-0.9	0.3	1.1	-1.2
Ulcerative Colitis	0.0	0.0	0.1	0.2	0.1	-0.0	-0.1
Blood Eosinophil Count	0.3	2.0	6.8	-2.6	-0.3	-0.2	-1.1
Blood Platelet Count	0.6	7.2	18.5	-2.9	0.5	-4.3	-1.3
Blood Red Count	0.3	3.2	6.3	-1.7	-1.9	0.2	-2.5
Blood White Count	0.8	6.0	11.0	-3.3	-1.4	-2.5	-2.2
Heel T-Score	6.7	52.9	161.3	3.9	12.7	5.3	2.6
BMI	0.7	4.2	12.4	-1.1	-0.4	1.8	-3.5
Height	0.7	13.6	22.8	1.6	-3.2	4.8	4.3
Waist Hip Ratio (WHR)	0.1	0.4	0.5	-0.7	0.6	-0.5	0.7
Systolic Blood Pressure	0.1	0.3	0.9	0.0	-0.2	0.2	1.0
Smoking Status	0.3	0.7	2.0	0.1	-1.4	-0.4	0.8
Allergy or Eczema	0.5	1.3	2.3	-1.3	1.5	0.4	-0.9
Cardiovascular Disease	0.2	0.7	1.3	-0.6	-1.1	-0.3	-1.1
Hypothyroidism (self reported)	0.1	0.2	0.5	0.7	0.3	-0.1	0.4
Respiratory disease	0.6	1.3	2.2	-1.5	-1.2	-0.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.2	-0.8	-1.5	-0.6	-1.3
Lung FEV1/FVC ratio	0.8	3.9	12.0	1.3	3.5	1.0	-0.9
Lung FVC	0.5	2.3	5.7	-2.4	-1.2	-1.4	-0.0
Neuroticism	0.3	0.6	1.0	0.9	-0.3	0.7	-1.0
Chronotype (morning person)	0.1	0.3	0.4	-0.6	-0.3	0.6	0.6
Hair Pigment	0.1	1.6	3.1	1.0	0.2	-1.8	1.5
Tanning	0.1	0.7	1.5	-0.6	1.2	-1.0	-0.2
Hand grip strength (left)	0.8	2.0	5.0	1.7	0.1	2.2	-0.0
Number of treatments/medications taken	1.5	2.7	4.7	-1.5	-2.2	-1.5	-1.3
Average weekly spirits intake	1.0	1.3	3.2	0.1	-1.8	-1.3	-0.5
Sensitivity / hurt feelings	0.3	0.5	1.3	1.1	-0.5	-0.4	-0.5
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.8	-0.2	-0.7	-2.0	-0.8
Hearing difficulty/problems: Yes	1.0	1.6	3.6	1.1	1.2	-0.4	1.9
Relative age of first facial hair	0.1	0.1	0.4	-0.6	-0.2	-0.1	-0.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.5	1.9	-0.8	0.5	0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	-0.4	-0.8	0.3	-0.7
Ever had hysterectomy (womb removed)	1.7	1.9	5.2	-0.2	-2.3	-1.5	-0.4
Systolic blood pressure, automated reading	0.2	0.5	0.8	-0.8	-0.9	-0.5	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.3	0.2	0.5	-0.5	0.4
Angina	0.5	0.7	1.8	0.9	1.3	-0.2	-0.1
Medication for hormone replacement therapy	2.0	2.2	3.3	1.7	1.8	0.5	1.6
Vitamin and mineral supplements	0.3	0.4	1.4	-0.3	-0.0	-1.2	0.0
Supplements: Zinc	0.6	0.7	2.5	-0.2	0.1	1.6	0.2
Medication: Co-codamol	0.1	0.1	0.2	0.5	0.1	-0.1	-0.2
Medication: Metformin	1.0	1.5	3.5	-0.6	-1.9	-0.1	-1.4
Diabetes (father)	0.0	0.0	0.0	-0.0	0.1	0.2	-0.0
Diabetes (mother)	1.1	1.4	2.0	-0.8	-1.4	-1.0	1.3
Severe depression (siblings)	0.1	0.1	0.3	-0.4	-0.1	-0.3	-0.5
Pack years adult smoking proportion	0.7	1.1	1.8	-0.8	-1.2	-1.3	0.6
Impedance of leg (right)	0.5	2.3	7.9	0.0	-0.8	-2.8	0.8
Leg fat-free mass (left)	1.1	5.8	16.6	-0.5	-2.0	4.1	-1.5
Trunk fat percentage	1.7	6.6	12.4	-2.2	-3.5	-0.1	-3.0
Hand grip strength (right)	0.5	1.4	3.8	1.2	0.3	1.9	-0.6
Townsend deprivation index at recruitment	1.1	1.5	2.5	-1.6	-1.5	-0.1	-1.2
Current tobacco smoking	0.8	1.3	2.3	-0.7	-1.1	-1.1	1.5
Average weekly fortified wine intake	0.5	0.6	1.1	-0.6	-0.6	0.8	-1.1
Maternal smoking around birth	0.3	0.4	0.8	0.6	-0.9	0.4	0.6
Fed-up feelings	0.7	1.3	3.8	0.6	-0.5	-2.0	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.7	-0.1	-1.3	-1.2	-1.2
Relative age voice broke	0.5	0.8	1.7	-0.9	-1.3	-0.1	-0.8
Taking other prescription medications	1.1	1.7	4.4	-0.3	-2.1	-0.6	-1.5
Age when periods started (menarche)	0.4	0.9	1.7	1.0	0.2	0.8	1.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-0.8	-1.3	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	21.8	1.2	4.7	0.7	0.6
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.2	-1.0	-2.0	-1.3	-1.4
Qualifications: CSEs or equivalent	0.8	1.0	2.3	-1.1	-0.0	0.6	-1.5
Serious illness, injury or assault to yourself	2.2	2.6	4.5	1.6	-1.4	-1.3	2.1
High blood pressure	1.1	3.1	7.5	-1.0	-2.7	-1.1	-1.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	1.9	-1.3	1.4	0.7	-1.4
Multivitamins +/- minerals	0.2	0.3	1.0	0.1	0.1	1.0	0.2
Stomach or abdominal pain in last month	1.2	1.5	3.8	-0.2	0.8	-1.3	1.9
Supplements: Glucosamine	0.4	0.6	0.9	0.7	0.9	-0.8	0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.1	-1.5	-1.2	-0.0	1.0
Medication: Atenolol	0.6	0.8	1.7	0.4	-1.1	0.1	-1.3
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.2	0.6	-1.0	0.9
Sitting height	0.4	2.6	5.7	-0.4	-1.4	2.4	1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.1	-0.5	-1.3	0.5
High blood pressure (mother)	0.9	1.2	4.0	-0.0	0.9	2.0	0.2
Body mass index (BMI)	0.7	2.8	6.8	-1.4	-1.1	1.1	-2.6
Impedance of leg (left)	0.3	1.5	5.0	-0.1	-0.8	-2.2	0.7
Leg predicted mass (left)	1.0	5.5	15.2	-0.5	-2.1	3.9	-1.5
Trunk fat mass	1.4	5.9	11.0	-1.8	-3.3	1.4	-2.8
Waist circumference	0.7	2.6	4.4	-0.8	-1.3	2.1	-2.0
Number of incorrect matches in round	0.9	1.5	3.2	1.6	1.8	-0.4	0.0
Past tobacco smoking	0.3	0.5	2.0	-1.4	-0.1	0.1	-0.3
Alcohol usually taken with meals	2.0	3.2	7.8	-0.7	-1.6	2.8	-1.4
Nervous feelings	0.6	1.2	1.9	1.1	-1.4	0.5	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.2	-0.3	-0.4	0.2
Hearing difficulty/problems with background noise	1.0	1.5	3.6	1.5	0.4	-0.3	1.9
Hair/balding pattern: Pattern 2	0.9	1.2	3.1	0.1	-1.0	-1.8	-0.8
Had menopause	0.1	0.1	0.3	0.5	-0.1	-0.4	-0.3
Had other major operations	0.5	0.6	1.3	0.7	-0.3	1.1	0.7
Forced vital capacity (FVC)	0.6	2.4	3.5	-1.0	-1.6	1.5	1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	20.9	0.9	4.6	1.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.5	1.2	-0.5	1.1	-0.7
Qualifications: None of the above	0.8	1.8	5.6	-0.4	-0.5	-2.4	1.1
Financial difficulties in last 2 years	0.5	0.6	2.1	-0.5	-1.5	-0.4	-0.2
Mouth/teeth dental problems	1.1	1.7	6.6	-2.6	-0.2	-0.4	-0.3
Heart attack	1.7	2.1	5.9	2.4	-0.5	-0.7	1.3
Allergy	0.4	0.9	1.7	1.3	-0.7	-0.2	1.2
Pain all over the body in last month	0.5	0.5	1.3	1.1	0.4	0.7	-0.1
Diabetes (self-reported)	0.2	0.4	1.1	-0.2	-1.1	-0.6	-0.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.4	-1.0	0.0	-1.1	-1.8
Medication: Ramipril	1.7	2.2	7.0	-1.2	-2.6	-0.6	-0.0
Medication: Simvastatin	0.8	1.2	4.0	0.6	-0.6	-2.0	0.0
Fluid intelligence score	0.7	1.4	2.7	-0.1	-1.6	1.5	-1.0
Illnesses of siblings	0.3	0.4	0.8	0.0	0.5	0.9	-0.8
Neuroticism score	0.2	0.5	0.7	0.6	-0.8	0.4	-0.9
Weight	1.1	5.6	13.4	-0.7	-2.1	3.7	-2.0
Impedance of arm (right)	0.5	2.6	7.6	-0.4	-1.5	-2.8	0.6
Arm fat percentage (right)	1.5	5.7	10.4	-2.4	-2.5	-0.7	-3.2
Trunk fat-free mass	1.2	6.9	26.1	0.3	-1.1	5.1	-0.5
Hip circumference	0.8	3.6	6.6	-1.0	-1.9	2.6	-1.8
Time employed in main current job	0.3	0.4	1.0	-0.7	-0.2	1.0	0.1
Alcohol intake versus 10 years previously	0.6	0.9	3.1	0.4	-0.2	1.8	0.3
Father’s age at death	0.3	0.4	0.9	0.8	0.2	0.0	1.0
Worrier / anxious feelings	0.5	0.9	2.5	0.1	0.5	1.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.4	-0.3	-1.8	-0.2	-0.5
Falls in the last year	0.6	0.8	1.6	-0.8	-0.3	1.3	-1.0
Hair/balding pattern: Pattern 3	2.2	3.3	6.3	1.5	2.5	2.1	0.5
Number of live births	0.6	0.8	1.6	-1.2	-0.5	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.1	-0.8	-0.8	1.8	0.8
Pulse rate	0.2	0.3	0.5	-0.2	0.7	-0.5	-0.6
Happiness	0.1	0.2	0.5	0.2	-0.7	0.2	-0.3
Noisy workplace	0.3	0.3	0.6	0.8	0.5	-0.3	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.3	1.4	0.9	1.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	5.6	2.4	0.4	0.7	1.8
Mouth/teeth dental problems: Dentures	1.0	1.7	3.0	1.7	-0.9	-1.5	0.8
Asthma	1.0	2.0	4.1	-2.0	-1.4	-1.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.6	-1.6	-1.4	0.6	-0.7
Medication: Cholesterol lowering	1.7	2.7	5.2	2.3	-0.8	-2.1	0.8
Depression (self-reported)	2.9	3.4	6.7	-1.4	-2.6	-2.0	-1.1
Medication: Lansoprazole	2.1	2.4	4.8	-0.4	-2.1	-2.2	-0.4
Prospective memory result	0.3	0.4	1.1	-0.2	-0.2	-0.6	-1.0
Lung cancer (father)	0.5	0.6	2.3	-1.5	-0.2	0.2	-0.3
Illnesses of mother	0.9	1.1	2.0	-0.8	-1.3	-0.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.3	-0.3	-0.1	2.1	0.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.2	-0.5	-0.1	-0.1
Impedance of arm (left)	0.8	3.8	9.8	-0.6	-2.2	-3.1	0.3
Arm fat mass (right)	1.2	5.1	8.9	-1.9	-2.5	1.3	-3.0
Trunk predicted mass	1.2	6.8	25.5	0.4	-1.1	5.0	-0.5
Standing height	1.0	9.8	31.5	1.5	-2.1	5.6	1.1
Length of working week for main job	2.1	2.3	3.8	-2.0	-0.6	1.7	-1.5
Exposure to tobacco smoke at home	0.4	0.5	0.9	0.9	0.7	0.7	0.2
Breastfed as a baby	0.2	0.2	0.5	0.7	0.4	-0.3	0.4
Tense / ‘highly strung’	0.5	0.8	1.6	1.0	0.2	1.3	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-0.6	-0.5	0.7	-1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-1.0	1.3	0.6	-0.5
Birth weight of first child	1.0	1.7	5.5	1.0	-0.3	2.4	-0.6
Peak expiratory flow (PEF)	0.4	0.8	1.3	-1.0	-0.9	1.1	-0.5
Pulse wave reflection index	0.1	0.1	0.3	0.6	-0.1	0.2	0.3
Ever highly irritable/argumentative for 2 days	1.8	2.1	4.6	0.1	-1.5	2.1	-1.2
Loud music exposure frequency	0.8	0.9	2.9	0.7	1.7	0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.2	1.1	1.0	-0.7	0.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.8	0.2	0.8	1.7	-1.6
Blood clot in the leg (DVT)	0.7	0.9	2.6	1.6	0.1	1.0	-0.3
Medication: Paracetamol	0.3	0.5	1.2	-0.0	0.1	1.1	-0.8
Headache pain in last month	0.8	1.5	3.4	-1.8	-0.9	-0.1	-1.3
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.1	-1.1	1.5	2.3	-0.2
Glaucoma (self-reported)	1.1	1.3	2.2	-0.8	-1.5	-1.3	0.7
Gout (self-reported)	0.4	0.5	0.6	0.7	-0.7	-0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	0.2	0.5	-0.1	-0.1
Medication: Amlodipine	0.4	0.5	1.1	-1.0	-0.8	0.2	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	-1.0	-0.8	-0.7	-0.4
Birth weight	0.4	0.8	1.5	1.2	-0.7	1.0	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.0	0.5	0.4	-0.5
High blood pressure (siblings)	0.4	0.5	1.4	-0.4	-1.2	-0.5	0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	3.1	-0.6	-1.0	1.8	1.6
Body fat percentage	1.4	5.6	9.0	-2.2	-2.9	-0.3	-3.0
Leg fat percentage (right)	1.2	4.4	9.2	-2.0	-2.0	-0.5	-3.0
Arm fat-free mass (right)	1.2	6.3	23.2	-0.1	-1.2	4.8	-0.6
Exposure to tobacco smoke outside home	1.2	1.5	2.5	-1.2	-1.6	1.3	-0.7
Comparative body size at age 10	1.0	2.8	7.8	1.4	2.8	-0.9	0.7
Number of full brothers	0.3	0.4	0.9	-0.2	-0.6	-0.4	-0.9
Worry too long after embarrassment	0.8	1.3	2.7	-0.8	-1.6	-0.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.3	-0.6	-0.7	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.3	-0.6	-0.7	0.3
Number of children fathered	0.4	0.5	1.3	0.7	1.1	-0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	-0.3	0.0	0.3	-0.2
Age at first live birth	0.2	0.4	1.2	-1.1	0.4	-0.3	-0.2
Pulse wave peak to peak time	0.0	0.0	0.2	-0.1	0.1	0.4	0.1
Health satisfaction	0.5	0.7	1.8	-0.4	-1.3	-0.8	-0.3
Shortness of breath walking on level ground	1.2	1.4	4.2	-0.6	-0.9	0.5	-2.1
Qualifications: College or University degree	0.8	2.5	9.2	0.8	-0.3	3.0	0.1
Eye problems/disorders: None of the above	0.7	0.9	2.1	1.5	0.1	1.2	-0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	-0.3	-0.1	0.4
Emphysema/chronic bronchitis	2.0	2.2	4.8	1.0	0.1	-2.2	1.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	-0.4	1.3	-0.5	0.2
Neck or shoulder pain in last month	0.3	0.4	0.9	-1.0	0.4	-0.6	0.5
Medication: Blood pressure	0.8	1.4	3.0	0.4	-1.7	-1.6	0.4
Angina (self-reported)	0.5	0.7	1.7	0.9	1.3	-0.1	-0.4
Migraine (self-reported)	0.3	0.4	1.3	0.4	-0.0	1.1	0.3
Medication: Ibuprofen	0.6	0.7	1.1	-1.0	-0.8	0.8	-0.6
Medication: Allopurinol	0.6	0.8	2.0	1.0	0.5	1.4	0.1
Medication: Omeprazole	0.2	0.2	0.8	0.1	-0.9	0.1	0.0
Medication: Seretide 50 evohaler	2.2	2.5	4.1	1.9	2.0	0.9	1.3
Mean time to correctly identify matches	0.8	1.5	3.6	0.1	-1.0	-1.1	-1.9
Heart disease (mother)	0.5	0.6	1.4	-1.2	0.6	-0.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.3	1.8	-0.2	-1.1	0.3
Whole body fat mass	1.2	5.0	8.1	-1.7	-2.8	1.3	-2.7
Leg fat mass (right)	1.0	3.8	6.9	-1.6	-2.1	1.2	-2.6
Arm predicted mass (right)	1.2	6.4	22.3	-0.1	-1.5	4.7	-1.0
Pulse rate, automated reading	0.9	2.8	7.9	-1.5	-0.7	-0.7	-2.8
Alcohol intake frequency.	0.4	1.0	2.6	0.4	-0.9	1.6	-0.5
Comparative height size at age 10	1.1	6.2	16.9	2.6	-0.7	4.1	0.8
Number of full sisters	0.4	0.5	1.2	0.8	0.2	-1.1	0.3
Suffer from ‘nerves’	0.9	1.3	2.2	1.4	0.4	1.5	-1.0
Overall health rating	0.5	1.2	2.4	0.7	-1.5	-1.3	0.5
Chest pain or discomfort	0.6	0.9	1.8	1.1	0.8	1.4	0.3
Had major operations	1.3	1.5	2.5	1.2	1.6	0.9	1.1
Age at last live birth	0.4	0.5	1.1	-0.1	1.1	0.4	0.9
Family relationship satisfaction	1.8	2.2	6.5	-1.1	-2.5	-0.3	-0.9
Leg pain on walking	0.4	0.4	1.3	-0.1	-0.6	1.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	-0.1	0.6	-1.1	-0.7
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.8	1.1	1.4	-0.8	1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	-1.7	0.3	-0.2	-1.2
Medication: Aspirin	1.0	1.3	4.2	0.2	-0.7	-2.1	0.6
Supplements: Vitamin C	0.2	0.2	0.5	-0.2	0.6	0.7	0.0
Knee pain experienced in last month	0.0	0.0	0.1	-0.3	0.2	0.1	-0.2
Hypertension (Self-reported)	1.0	2.7	5.5	-1.3	-2.4	-0.9	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.9	1.7	-0.5	-0.3	0.4
Illnesses of father: Heart disease	1.6	2.2	5.7	-2.4	-1.3	-0.5	-1.2
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.3	-0.3	-0.6	0.2
Smoking status: Previous	0.8	1.2	3.6	1.9	0.9	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.3	12.4	2.6	1.6	3.5	3.4
Whole body fat-free mass	1.2	7.1	25.1	-0.1	-1.5	5.0	-1.0
Leg fat-free mass (right)	1.2	6.6	19.6	-0.6	-2.0	4.4	-1.6
Arm fat percentage (left)	1.5	5.9	10.2	-2.4	-2.8	-0.6	-3.2
Average weekly red wine intake	1.6	2.4	6.6	1.2	1.2	2.6	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	-0.1	0.2	-0.6	0.9
Mood swings	0.4	0.8	1.9	0.5	-1.4	0.5	-0.9
Loneliness, isolation	1.4	1.9	2.8	-1.1	-1.7	-1.6	-1.1
Long-standing illness, disability or infirmity	0.4	0.7	1.1	0.5	-1.1	0.6	1.0
Ever had bowel cancer screening	1.1	1.2	2.0	1.1	1.4	-0.1	1.4
Diabetes diagnosed by doctor	1.3	2.2	6.0	-0.7	-2.5	-0.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.1	-0.1	0.4	0.3	1.4
Friendships satisfaction	1.3	1.6	4.5	-2.1	-0.9	-0.0	-0.9
Qualifications: nursing, teaching	1.6	2.5	4.6	2.1	0.8	2.1	0.6
Commuting to job workplace: Walk	3.4	3.6	5.4	2.3	2.2	0.7	1.9
Eye problems/disorders: Cataract	0.6	0.6	1.4	-1.2	1.1	0.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.4	2.1	0.1	0.4	0.5
Medication for cholesterol	0.5	0.8	1.6	0.9	-1.3	0.8	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.5	0.3	-1.2	-1.2	-0.2
Back pain experienced in last month	0.5	0.7	1.3	0.8	0.7	-0.5	1.1
Mineral and other dietary supplements	0.2	0.2	0.7	-0.1	-0.9	0.2	-0.2
Breast cancer (self-reported)	0.5	0.6	2.2	1.5	0.2	0.4	0.1
Asthma (self-reported)	0.9	1.7	3.6	-1.9	-1.5	-0.9	-0.6
Osteoporosis (self-reported)	2.4	2.9	9.2	-0.4	-3.0	-0.9	-1.2
Osteoarthritis (self-reported)	0.5	0.6	2.0	0.1	0.7	-1.4	0.1
Medication: Aspirin	0.9	1.2	4.2	0.3	-0.6	-2.1	0.2
Medication: Gliclazide	1.4	1.6	3.5	-0.6	-1.9	1.1	-1.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	1.4	0.0	0.3	-0.2
Smoking status: Current	0.8	1.2	2.1	-0.7	-1.5	-0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	1.8	-1.2	0.3	-1.3	-1.4
Whole body water mass	1.2	7.0	24.4	-0.1	-1.6	4.9	-1.0
Leg predicted mass (right)	1.2	6.6	19.8	-0.6	-2.0	4.5	-1.6
Arm fat mass (left)	1.1	4.3	7.0	-1.7	-2.4	1.3	-2.6
Number of self-reported non-cancer illnesses	2.1	3.6	6.4	-1.4	-2.5	-1.5	-1.9
Average weekly champagne plus white wine intake	0.6	0.9	2.3	-1.5	0.3	0.5	0.9
Miserableness	0.3	0.5	0.7	0.2	-0.8	-0.7	0.8
Guilty feelings	0.3	0.5	0.9	0.9	0.2	0.3	1.0
Wears glasses or contact lenses	0.2	0.2	0.6	0.2	-0.6	0.7	-0.1
Ever taken oral contraceptive pill	0.6	0.6	1.9	-0.2	0.3	-0.7	1.4
Hearing aid user	0.8	0.9	2.6	0.9	1.6	0.3	0.5
Mother’s age at death	0.3	0.4	1.3	1.1	0.1	0.1	0.5
Financial situation satisfaction	0.3	0.4	0.7	-0.4	-0.3	-0.8	-0.7
Tinnitus: Yes, now most or all of the time	2.0	2.3	5.7	1.3	1.4	0.3	2.4
Commuting to job workplace: Public transport	1.6	1.9	3.3	-1.4	-1.8	-0.3	-1.5
Eye problems/disorders: Glaucoma	1.5	1.8	2.7	-0.2	-1.6	-1.6	1.4
Medication: Blood pressure	0.9	1.8	2.8	-1.7	-1.0	-1.0	-1.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.3	-0.3	-0.4	-1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	-0.8	0.8	-1.0	-0.1
High cholesterol (Self-reported)	1.5	2.6	9.1	0.4	-0.9	-3.0	0.7
Medication: Bendroflumethiazide	2.2	3.4	8.9	-0.9	-1.9	-3.0	0.5
Medication: Paracetamol	0.5	0.8	2.0	0.6	0.6	1.4	-0.7
Medication: Lisinopril	1.0	1.3	3.7	0.9	-0.6	-1.9	-0.4
Medication: Atorvastatin	1.0	1.3	2.5	0.8	1.0	-1.0	1.6
Illnesses of father: High blood pressure	0.5	0.6	2.0	0.1	0.1	-0.7	1.4
Alcohol drinker status: Never	0.6	0.7	2.3	0.3	0.2	1.5	-0.5
Ever smoked	0.1	0.2	0.6	0.8	-0.1	-0.3	-0.2
Basal metabolic rate	1.3	7.0	22.4	-0.4	-1.9	4.7	-1.4
Leg fat percentage (left)	1.2	4.3	9.2	-2.1	-1.9	-0.3	-3.0
Arm fat-free mass (left)	1.3	6.4	22.2	-0.2	-1.5	4.7	-1.1
Number of operations (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.5	-0.1
Average weekly beer plus cider intake	1.8	2.6	4.1	1.6	2.0	1.2	1.5
Irritability	0.2	0.3	0.5	0.7	-0.7	0.2	0.5
Risk taking	0.2	0.4	0.7	-0.1	-0.4	0.8	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.8	0.0	-0.5	1.4	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	1.0	0.2	-0.1	-1.0	0.6
Age started oral contraceptive pill	0.4	0.6	1.3	-0.8	-0.5	-0.1	-1.1
Diastolic blood pressure, automated reading	1.7	5.2	13.0	-2.4	-3.6	-0.7	-1.3
Ever depressed for a whole week	1.6	2.0	5.2	1.3	-0.0	2.3	-1.1
Unable to work because of sickness or disability	0.6	0.7	1.4	1.2	0.7	-0.3	0.9
Commuting to job workplace: Cycle	1.4	1.6	4.1	2.0	-0.9	0.0	1.3
Myopia	0.5	0.8	1.8	1.1	-0.3	0.1	1.3
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.3	0.9	2.5	1.2	1.5
Cholesterol lowering medication	0.6	0.9	2.6	-1.6	0.2	-1.0	0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	0.7	-1.4	0.1	0.4
Pain experienced in last month	0.5	0.8	1.8	0.6	-0.3	-0.9	1.4
Supplements: Calcium	0.6	0.7	2.1	-1.5	-0.4	-0.5	-0.5
Basal cell carcinoma (self-reported)	1.6	1.8	6.0	-1.0	-0.6	0.2	-2.4
Heart attack/myocardial infarction (self-reported)	1.8	2.3	6.4	2.5	-0.7	-0.7	1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.9	1.4	0.2	1.0	-0.1
Heart disease (siblings)	0.6	0.8	2.2	-0.2	-0.5	-0.8	-1.5
Alcohol drinker status: Previous	0.8	0.9	1.3	-0.4	-1.1	1.0	-1.1
Pack years of smoking	0.7	1.0	2.1	-0.5	-1.3	-1.4	0.4
Impedance of whole body	0.5	2.4	7.0	-0.3	-1.3	-2.6	0.8
Leg fat mass (left)	1.0	3.8	6.7	-1.6	-2.0	1.3	-2.6
Arm predicted mass (left)	1.2	6.1	20.5	-0.5	-1.6	4.5	-1.1