Hub : Genes

MTIF2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1478 0.0513 0.00067 0.014 NA 0.020 NA 0.020 0.026 NA 0.00980 NA 0.0110
2 GTEx Nerve Tibial 0.1145 0.0464 0.00470 0.006 NA 0.040 NA 0.026 0.110 NA 0.00081 NA 0.0059
3 GTEx Testis 0.1270 0.0540 0.00650 0.006 NA 0.013 NA 0.009 0.160 NA 0.08500 NA 0.1200
4 YFS Blood 0.0223 0.0096 0.00410 0.000 0.002 0.002 0.004 0.000 0.250 0.046 0.06200 0.013 0.2800

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.7 1.3 -0.2 -1.2 -1.1 -0.4
Bipolar Disorder or Schizophrenia 0.5 1.2 3.5 -0.9 -1.9 -0.7 0.2
Depressed Affect (Nagel 2018) 0.4 0.9 1.6 -0.9 -1.3 -0.8 -0.8
Depression (Nagel 2018) 0.5 0.8 1.9 -0.1 -0.8 -1.4 -0.9
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.9 -0.4 -0.6 1.7 -0.3
Neuroticism (Nagel 2018) 0.1 0.2 0.4 0.6 -0.4 0.3 -0.4
Schizophrenia (2018) 0.4 0.9 2.2 -1.0 -1.5 0.1 0.6
Schizophrenia vs Biploar Disorder 0.5 0.7 1.8 0.8 -0.1 1.3 -0.5
Worry (Nagel 2018) 0.5 1.1 2.6 1.6 0.5 1.2 -0.4
Alzheimer’s Disease (in mother) 1.2 1.4 2.4 1.0 1.6 0.4 1.4
Alzheimer’s Disease (in father) 1.1 1.2 1.8 1.1 -1.1 -1.3 0.8
Alzheimer’s Disease (including proxy) 1.5 2.2 4.2 1.8 1.0 -0.5 2.0
Crohns Disease (2017) 0.3 0.6 1.6 -0.3 -0.9 -0.2 -1.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.2 0.4 -0.5 -0.4 -0.3
Ulcerative Colitis (UC) 0.2 0.4 0.8 0.6 0.2 -0.9 0.7
Major Depression (MDD) 1.1 1.3 3.4 -0.6 -1.9 1.1 0.4
Reaction Time 0.4 0.7 1.9 0.6 -0.4 0.6 -1.4
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.7 0.3 -0.2 1.6 -0.6
Breast Cancer 0.4 1.1 2.0 0.0 1.4 1.4 0.7
Ovarian Cancer 1.5 2.0 5.2 0.2 1.6 -0.4 2.3
Prostate Cancer 0.5 0.8 2.4 0.6 -0.3 1.6 0.4
Age at First Birth 0.9 1.4 3.2 1.1 0.9 1.8 -0.4
Bipolar Disorder (2011) 0.3 0.3 1.1 -0.3 -1.0 -0.1 -0.4
Body Mass Index (BMI) (2010) 1.0 1.4 3.1 -1.3 0.8 0.5 -1.8
Coronary Artery Disease (CAD) 1.0 1.2 3.4 -1.9 0.4 -0.6 1.0
Crohns Disease (2012) 0.4 0.6 2.0 -0.0 -0.5 0.4 -1.4
Mean Putamen Volume 0.7 0.8 2.4 0.5 -0.4 -0.7 -1.6
Fasting Glucose 1.1 1.4 2.4 -0.7 -1.5 -1.5 -0.6
HbA1C 0.5 0.6 1.5 -0.9 -1.2 0.2 0.1
HDL Cholesterol 0.3 0.5 1.0 -0.2 -0.5 -0.9 -1.0
LDL Cholesterol 0.6 1.0 2.7 -0.5 -0.7 -1.6 0.6
Lupus 0.7 1.0 3.1 -0.2 0.7 1.8 -0.7
Neuroticism (2016) 0.3 0.4 1.5 0.1 -1.2 0.1 0.2
Primary Biliary Cirrhosis 0.5 0.7 1.4 -1.2 0.1 -0.6 1.0
Rheumatoid Arthritis 1.9 2.6 8.5 -2.9 -0.9 -0.0 -1.0
Schizophrenia (2014) 0.5 1.1 2.7 -1.3 -1.6 0.1 0.5
Triglycerides 0.1 0.2 0.4 -0.0 0.3 -0.5 -0.6
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.4 -0.9 0.3 1.1 -1.2
Ulcerative Colitis 0.0 0.0 0.1 0.2 0.1 -0.0 -0.1
Blood Eosinophil Count 0.3 2.0 6.8 -2.6 -0.3 -0.2 -1.1
Blood Platelet Count 0.6 7.2 18.5 -2.9 0.5 -4.3 -1.3
Blood Red Count 0.3 3.2 6.3 -1.7 -1.9 0.2 -2.5
Blood White Count 0.8 6.0 11.0 -3.3 -1.4 -2.5 -2.2
Heel T-Score 6.7 52.9 161.3 3.9 12.7 5.3 2.6
BMI 0.7 4.2 12.4 -1.1 -0.4 1.8 -3.5
Height 0.7 13.6 22.8 1.6 -3.2 4.8 4.3
Waist Hip Ratio (WHR) 0.1 0.4 0.5 -0.7 0.6 -0.5 0.7
Systolic Blood Pressure 0.1 0.3 0.9 0.0 -0.2 0.2 1.0
Smoking Status 0.3 0.7 2.0 0.1 -1.4 -0.4 0.8
Allergy or Eczema 0.5 1.3 2.3 -1.3 1.5 0.4 -0.9
Cardiovascular Disease 0.2 0.7 1.3 -0.6 -1.1 -0.3 -1.1
Hypothyroidism (self reported) 0.1 0.2 0.5 0.7 0.3 -0.1 0.4
Respiratory disease 0.6 1.3 2.2 -1.5 -1.2 -0.9 -0.8
Type 2 Diabetes (T2D) (2018) 0.7 1.2 2.2 -0.8 -1.5 -0.6 -1.3
Lung FEV1/FVC ratio 0.8 3.9 12.0 1.3 3.5 1.0 -0.9
Lung FVC 0.5 2.3 5.7 -2.4 -1.2 -1.4 -0.0
Neuroticism 0.3 0.6 1.0 0.9 -0.3 0.7 -1.0
Chronotype (morning person) 0.1 0.3 0.4 -0.6 -0.3 0.6 0.6
Hair Pigment 0.1 1.6 3.1 1.0 0.2 -1.8 1.5
Tanning 0.1 0.7 1.5 -0.6 1.2 -1.0 -0.2
Hand grip strength (left) 0.8 2.0 5.0 1.7 0.1 2.2 -0.0
Number of treatments/medications taken 1.5 2.7 4.7 -1.5 -2.2 -1.5 -1.3
Average weekly spirits intake 1.0 1.3 3.2 0.1 -1.8 -1.3 -0.5
Sensitivity / hurt feelings 0.3 0.5 1.3 1.1 -0.5 -0.4 -0.5
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.8 -0.2 -0.7 -2.0 -0.8
Hearing difficulty/problems: Yes 1.0 1.6 3.6 1.1 1.2 -0.4 1.9
Relative age of first facial hair 0.1 0.1 0.4 -0.6 -0.2 -0.1 -0.3
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.5 1.9 -0.8 0.5 0.3
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.7 -0.4 -0.8 0.3 -0.7
Ever had hysterectomy (womb removed) 1.7 1.9 5.2 -0.2 -2.3 -1.5 -0.4
Systolic blood pressure, automated reading 0.2 0.5 0.8 -0.8 -0.9 -0.5 -0.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.3 0.2 0.5 -0.5 0.4
Angina 0.5 0.7 1.8 0.9 1.3 -0.2 -0.1
Medication for hormone replacement therapy 2.0 2.2 3.3 1.7 1.8 0.5 1.6
Vitamin and mineral supplements 0.3 0.4 1.4 -0.3 -0.0 -1.2 0.0
Supplements: Zinc 0.6 0.7 2.5 -0.2 0.1 1.6 0.2
Medication: Co-codamol 0.1 0.1 0.2 0.5 0.1 -0.1 -0.2
Medication: Metformin 1.0 1.5 3.5 -0.6 -1.9 -0.1 -1.4
Diabetes (father) 0.0 0.0 0.0 -0.0 0.1 0.2 -0.0
Diabetes (mother) 1.1 1.4 2.0 -0.8 -1.4 -1.0 1.3
Severe depression (siblings) 0.1 0.1 0.3 -0.4 -0.1 -0.3 -0.5
Pack years adult smoking proportion 0.7 1.1 1.8 -0.8 -1.2 -1.3 0.6
Impedance of leg (right) 0.5 2.3 7.9 0.0 -0.8 -2.8 0.8
Leg fat-free mass (left) 1.1 5.8 16.6 -0.5 -2.0 4.1 -1.5
Trunk fat percentage 1.7 6.6 12.4 -2.2 -3.5 -0.1 -3.0
Hand grip strength (right) 0.5 1.4 3.8 1.2 0.3 1.9 -0.6
Townsend deprivation index at recruitment 1.1 1.5 2.5 -1.6 -1.5 -0.1 -1.2
Current tobacco smoking 0.8 1.3 2.3 -0.7 -1.1 -1.1 1.5
Average weekly fortified wine intake 0.5 0.6 1.1 -0.6 -0.6 0.8 -1.1
Maternal smoking around birth 0.3 0.4 0.8 0.6 -0.9 0.4 0.6
Fed-up feelings 0.7 1.3 3.8 0.6 -0.5 -2.0 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 1.7 -0.1 -1.3 -1.2 -1.2
Relative age voice broke 0.5 0.8 1.7 -0.9 -1.3 -0.1 -0.8
Taking other prescription medications 1.1 1.7 4.4 -0.3 -2.1 -0.6 -1.5
Age when periods started (menarche) 0.4 0.9 1.7 1.0 0.2 0.8 1.3
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.6 -0.8 -1.3 0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.7 6.1 21.8 1.2 4.7 0.7 0.6
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 4.2 -1.0 -2.0 -1.3 -1.4
Qualifications: CSEs or equivalent 0.8 1.0 2.3 -1.1 -0.0 0.6 -1.5
Serious illness, injury or assault to yourself 2.2 2.6 4.5 1.6 -1.4 -1.3 2.1
High blood pressure 1.1 3.1 7.5 -1.0 -2.7 -1.1 -1.7
Hayfever, allergic rhinitis or eczema 0.7 1.5 1.9 -1.3 1.4 0.7 -1.4
Multivitamins +/- minerals 0.2 0.3 1.0 0.1 0.1 1.0 0.2
Stomach or abdominal pain in last month 1.2 1.5 3.8 -0.2 0.8 -1.3 1.9
Supplements: Glucosamine 0.4 0.6 0.9 0.7 0.9 -0.8 0.7
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 2.1 -1.5 -1.2 -0.0 1.0
Medication: Atenolol 0.6 0.8 1.7 0.4 -1.1 0.1 -1.3
Medication: Levothyroxine sodium 0.3 0.5 0.9 -0.2 0.6 -1.0 0.9
Sitting height 0.4 2.6 5.7 -0.4 -1.4 2.4 1.6
Chronic bronchitis/emphysema (father) 0.5 0.6 1.8 -0.1 -0.5 -1.3 0.5
High blood pressure (mother) 0.9 1.2 4.0 -0.0 0.9 2.0 0.2
Body mass index (BMI) 0.7 2.8 6.8 -1.4 -1.1 1.1 -2.6
Impedance of leg (left) 0.3 1.5 5.0 -0.1 -0.8 -2.2 0.7
Leg predicted mass (left) 1.0 5.5 15.2 -0.5 -2.1 3.9 -1.5
Trunk fat mass 1.4 5.9 11.0 -1.8 -3.3 1.4 -2.8
Waist circumference 0.7 2.6 4.4 -0.8 -1.3 2.1 -2.0
Number of incorrect matches in round 0.9 1.5 3.2 1.6 1.8 -0.4 0.0
Past tobacco smoking 0.3 0.5 2.0 -1.4 -0.1 0.1 -0.3
Alcohol usually taken with meals 2.0 3.2 7.8 -0.7 -1.6 2.8 -1.4
Nervous feelings 0.6 1.2 1.9 1.1 -1.4 0.5 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 0.2 -0.3 -0.4 0.2
Hearing difficulty/problems with background noise 1.0 1.5 3.6 1.5 0.4 -0.3 1.9
Hair/balding pattern: Pattern 2 0.9 1.2 3.1 0.1 -1.0 -1.8 -0.8
Had menopause 0.1 0.1 0.3 0.5 -0.1 -0.4 -0.3
Had other major operations 0.5 0.6 1.3 0.7 -0.3 1.1 0.7
Forced vital capacity (FVC) 0.6 2.4 3.5 -1.0 -1.6 1.5 1.9
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 20.9 0.9 4.6 1.4 0.6
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.5 1.2 -0.5 1.1 -0.7
Qualifications: None of the above 0.8 1.8 5.6 -0.4 -0.5 -2.4 1.1
Financial difficulties in last 2 years 0.5 0.6 2.1 -0.5 -1.5 -0.4 -0.2
Mouth/teeth dental problems 1.1 1.7 6.6 -2.6 -0.2 -0.4 -0.3
Heart attack 1.7 2.1 5.9 2.4 -0.5 -0.7 1.3
Allergy 0.4 0.9 1.7 1.3 -0.7 -0.2 1.2
Pain all over the body in last month 0.5 0.5 1.3 1.1 0.4 0.7 -0.1
Diabetes (self-reported) 0.2 0.4 1.1 -0.2 -1.1 -0.6 -0.0
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.4 -1.0 0.0 -1.1 -1.8
Medication: Ramipril 1.7 2.2 7.0 -1.2 -2.6 -0.6 -0.0
Medication: Simvastatin 0.8 1.2 4.0 0.6 -0.6 -2.0 0.0
Fluid intelligence score 0.7 1.4 2.7 -0.1 -1.6 1.5 -1.0
Illnesses of siblings 0.3 0.4 0.8 0.0 0.5 0.9 -0.8
Neuroticism score 0.2 0.5 0.7 0.6 -0.8 0.4 -0.9
Weight 1.1 5.6 13.4 -0.7 -2.1 3.7 -2.0
Impedance of arm (right) 0.5 2.6 7.6 -0.4 -1.5 -2.8 0.6
Arm fat percentage (right) 1.5 5.7 10.4 -2.4 -2.5 -0.7 -3.2
Trunk fat-free mass 1.2 6.9 26.1 0.3 -1.1 5.1 -0.5
Hip circumference 0.8 3.6 6.6 -1.0 -1.9 2.6 -1.8
Time employed in main current job 0.3 0.4 1.0 -0.7 -0.2 1.0 0.1
Alcohol intake versus 10 years previously 0.6 0.9 3.1 0.4 -0.2 1.8 0.3
Father’s age at death 0.3 0.4 0.9 0.8 0.2 0.0 1.0
Worrier / anxious feelings 0.5 0.9 2.5 0.1 0.5 1.6 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 3.4 -0.3 -1.8 -0.2 -0.5
Falls in the last year 0.6 0.8 1.6 -0.8 -0.3 1.3 -1.0
Hair/balding pattern: Pattern 3 2.2 3.3 6.3 1.5 2.5 2.1 0.5
Number of live births 0.6 0.8 1.6 -1.2 -0.5 -0.9 -0.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 3.1 -0.8 -0.8 1.8 0.8
Pulse rate 0.2 0.3 0.5 -0.2 0.7 -0.5 -0.6
Happiness 0.1 0.2 0.5 0.2 -0.7 0.2 -0.3
Noisy workplace 0.3 0.3 0.6 0.8 0.5 -0.3 0.6
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.3 1.4 0.9 1.5 0.2
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 5.6 2.4 0.4 0.7 1.8
Mouth/teeth dental problems: Dentures 1.0 1.7 3.0 1.7 -0.9 -1.5 0.8
Asthma 1.0 2.0 4.1 -2.0 -1.4 -1.1 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.3 2.6 -1.6 -1.4 0.6 -0.7
Medication: Cholesterol lowering 1.7 2.7 5.2 2.3 -0.8 -2.1 0.8
Depression (self-reported) 2.9 3.4 6.7 -1.4 -2.6 -2.0 -1.1
Medication: Lansoprazole 2.1 2.4 4.8 -0.4 -2.1 -2.2 -0.4
Prospective memory result 0.3 0.4 1.1 -0.2 -0.2 -0.6 -1.0
Lung cancer (father) 0.5 0.6 2.3 -1.5 -0.2 0.2 -0.3
Illnesses of mother 0.9 1.1 2.0 -0.8 -1.3 -0.2 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.3 -0.3 -0.1 2.1 0.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 0.2 -0.5 -0.1 -0.1
Impedance of arm (left) 0.8 3.8 9.8 -0.6 -2.2 -3.1 0.3
Arm fat mass (right) 1.2 5.1 8.9 -1.9 -2.5 1.3 -3.0
Trunk predicted mass 1.2 6.8 25.5 0.4 -1.1 5.0 -0.5
Standing height 1.0 9.8 31.5 1.5 -2.1 5.6 1.1
Length of working week for main job 2.1 2.3 3.8 -2.0 -0.6 1.7 -1.5
Exposure to tobacco smoke at home 0.4 0.5 0.9 0.9 0.7 0.7 0.2
Breastfed as a baby 0.2 0.2 0.5 0.7 0.4 -0.3 0.4
Tense / ‘highly strung’ 0.5 0.8 1.6 1.0 0.2 1.3 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.0 -0.6 -0.5 0.7 -1.0
Hair/balding pattern: Pattern 4 0.3 0.8 1.6 -1.0 1.3 0.6 -0.5
Birth weight of first child 1.0 1.7 5.5 1.0 -0.3 2.4 -0.6
Peak expiratory flow (PEF) 0.4 0.8 1.3 -1.0 -0.9 1.1 -0.5
Pulse wave reflection index 0.1 0.1 0.3 0.6 -0.1 0.2 0.3
Ever highly irritable/argumentative for 2 days 1.8 2.1 4.6 0.1 -1.5 2.1 -1.2
Loud music exposure frequency 0.8 0.9 2.9 0.7 1.7 0.4 0.1
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.2 1.1 1.0 -0.7 0.9
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 2.8 0.2 0.8 1.7 -1.6
Blood clot in the leg (DVT) 0.7 0.9 2.6 1.6 0.1 1.0 -0.3
Medication: Paracetamol 0.3 0.5 1.2 -0.0 0.1 1.1 -0.8
Headache pain in last month 0.8 1.5 3.4 -1.8 -0.9 -0.1 -1.3
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 5.1 -1.1 1.5 2.3 -0.2
Glaucoma (self-reported) 1.1 1.3 2.2 -0.8 -1.5 -1.3 0.7
Gout (self-reported) 0.4 0.5 0.6 0.7 -0.7 -0.6 -0.8
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.3 0.2 0.5 -0.1 -0.1
Medication: Amlodipine 0.4 0.5 1.1 -1.0 -0.8 0.2 -0.5
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 -1.0 -0.8 -0.7 -0.4
Birth weight 0.4 0.8 1.5 1.2 -0.7 1.0 0.5
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 0.0 0.5 0.4 -0.5
High blood pressure (siblings) 0.4 0.5 1.4 -0.4 -1.2 -0.5 0.6
Forced vital capacity (FVC), Best measure 0.5 1.7 3.1 -0.6 -1.0 1.8 1.6
Body fat percentage 1.4 5.6 9.0 -2.2 -2.9 -0.3 -3.0
Leg fat percentage (right) 1.2 4.4 9.2 -2.0 -2.0 -0.5 -3.0
Arm fat-free mass (right) 1.2 6.3 23.2 -0.1 -1.2 4.8 -0.6
Exposure to tobacco smoke outside home 1.2 1.5 2.5 -1.2 -1.6 1.3 -0.7
Comparative body size at age 10 1.0 2.8 7.8 1.4 2.8 -0.9 0.7
Number of full brothers 0.3 0.4 0.9 -0.2 -0.6 -0.4 -0.9
Worry too long after embarrassment 0.8 1.3 2.7 -0.8 -1.6 -0.1 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.3 -0.6 -0.7 0.2
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.3 -0.6 -0.7 0.3
Number of children fathered 0.4 0.5 1.3 0.7 1.1 -0.5 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.1 0.1 -0.3 0.0 0.3 -0.2
Age at first live birth 0.2 0.4 1.2 -1.1 0.4 -0.3 -0.2
Pulse wave peak to peak time 0.0 0.0 0.2 -0.1 0.1 0.4 0.1
Health satisfaction 0.5 0.7 1.8 -0.4 -1.3 -0.8 -0.3
Shortness of breath walking on level ground 1.2 1.4 4.2 -0.6 -0.9 0.5 -2.1
Qualifications: College or University degree 0.8 2.5 9.2 0.8 -0.3 3.0 0.1
Eye problems/disorders: None of the above 0.7 0.9 2.1 1.5 0.1 1.2 -0.0
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 -0.2 -0.3 -0.1 0.4
Emphysema/chronic bronchitis 2.0 2.2 4.8 1.0 0.1 -2.2 1.8
Medication for pain relief, constipation, heartburn 0.3 0.5 1.6 -0.4 1.3 -0.5 0.2
Neck or shoulder pain in last month 0.3 0.4 0.9 -1.0 0.4 -0.6 0.5
Medication: Blood pressure 0.8 1.4 3.0 0.4 -1.7 -1.6 0.4
Angina (self-reported) 0.5 0.7 1.7 0.9 1.3 -0.1 -0.4
Migraine (self-reported) 0.3 0.4 1.3 0.4 -0.0 1.1 0.3
Medication: Ibuprofen 0.6 0.7 1.1 -1.0 -0.8 0.8 -0.6
Medication: Allopurinol 0.6 0.8 2.0 1.0 0.5 1.4 0.1
Medication: Omeprazole 0.2 0.2 0.8 0.1 -0.9 0.1 0.0
Medication: Seretide 50 evohaler 2.2 2.5 4.1 1.9 2.0 0.9 1.3
Mean time to correctly identify matches 0.8 1.5 3.6 0.1 -1.0 -1.1 -1.9
Heart disease (mother) 0.5 0.6 1.4 -1.2 0.6 -0.3 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.3 1.8 -0.2 -1.1 0.3
Whole body fat mass 1.2 5.0 8.1 -1.7 -2.8 1.3 -2.7
Leg fat mass (right) 1.0 3.8 6.9 -1.6 -2.1 1.2 -2.6
Arm predicted mass (right) 1.2 6.4 22.3 -0.1 -1.5 4.7 -1.0
Pulse rate, automated reading 0.9 2.8 7.9 -1.5 -0.7 -0.7 -2.8
Alcohol intake frequency. 0.4 1.0 2.6 0.4 -0.9 1.6 -0.5
Comparative height size at age 10 1.1 6.2 16.9 2.6 -0.7 4.1 0.8
Number of full sisters 0.4 0.5 1.2 0.8 0.2 -1.1 0.3
Suffer from ‘nerves’ 0.9 1.3 2.2 1.4 0.4 1.5 -1.0
Overall health rating 0.5 1.2 2.4 0.7 -1.5 -1.3 0.5
Chest pain or discomfort 0.6 0.9 1.8 1.1 0.8 1.4 0.3
Had major operations 1.3 1.5 2.5 1.2 1.6 0.9 1.1
Age at last live birth 0.4 0.5 1.1 -0.1 1.1 0.4 0.9
Family relationship satisfaction 1.8 2.2 6.5 -1.1 -2.5 -0.3 -0.9
Leg pain on walking 0.4 0.4 1.3 -0.1 -0.6 1.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 -0.1 0.6 -1.1 -0.7
Commuting to job workplace: Car/motor vehicle 1.1 1.2 1.8 1.1 1.4 -0.8 1.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.0 -1.7 0.3 -0.2 -1.2
Medication: Aspirin 1.0 1.3 4.2 0.2 -0.7 -2.1 0.6
Supplements: Vitamin C 0.2 0.2 0.5 -0.2 0.6 0.7 0.0
Knee pain experienced in last month 0.0 0.0 0.1 -0.3 0.2 0.1 -0.2
Hypertension (Self-reported) 1.0 2.7 5.5 -1.3 -2.4 -0.9 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.9 1.7 -0.5 -0.3 0.4
Illnesses of father: Heart disease 1.6 2.2 5.7 -2.4 -1.3 -0.5 -1.2
Illnesses of siblings: Diabetes 0.1 0.2 0.4 0.3 -0.3 -0.6 0.2
Smoking status: Previous 0.8 1.2 3.6 1.9 0.9 0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 4.0 8.3 12.4 2.6 1.6 3.5 3.4
Whole body fat-free mass 1.2 7.1 25.1 -0.1 -1.5 5.0 -1.0
Leg fat-free mass (right) 1.2 6.6 19.6 -0.6 -2.0 4.4 -1.6
Arm fat percentage (left) 1.5 5.9 10.2 -2.4 -2.8 -0.6 -3.2
Average weekly red wine intake 1.6 2.4 6.6 1.2 1.2 2.6 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.8 -0.1 0.2 -0.6 0.9
Mood swings 0.4 0.8 1.9 0.5 -1.4 0.5 -0.9
Loneliness, isolation 1.4 1.9 2.8 -1.1 -1.7 -1.6 -1.1
Long-standing illness, disability or infirmity 0.4 0.7 1.1 0.5 -1.1 0.6 1.0
Ever had bowel cancer screening 1.1 1.2 2.0 1.1 1.4 -0.1 1.4
Diabetes diagnosed by doctor 1.3 2.2 6.0 -0.7 -2.5 -0.8 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.1 -0.1 0.4 0.3 1.4
Friendships satisfaction 1.3 1.6 4.5 -2.1 -0.9 -0.0 -0.9
Qualifications: nursing, teaching 1.6 2.5 4.6 2.1 0.8 2.1 0.6
Commuting to job workplace: Walk 3.4 3.6 5.4 2.3 2.2 0.7 1.9
Eye problems/disorders: Cataract 0.6 0.6 1.4 -1.2 1.1 0.0 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 4.4 2.1 0.1 0.4 0.5
Medication for cholesterol 0.5 0.8 1.6 0.9 -1.3 0.8 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.5 0.3 -1.2 -1.2 -0.2
Back pain experienced in last month 0.5 0.7 1.3 0.8 0.7 -0.5 1.1
Mineral and other dietary supplements 0.2 0.2 0.7 -0.1 -0.9 0.2 -0.2
Breast cancer (self-reported) 0.5 0.6 2.2 1.5 0.2 0.4 0.1
Asthma (self-reported) 0.9 1.7 3.6 -1.9 -1.5 -0.9 -0.6
Osteoporosis (self-reported) 2.4 2.9 9.2 -0.4 -3.0 -0.9 -1.2
Osteoarthritis (self-reported) 0.5 0.6 2.0 0.1 0.7 -1.4 0.1
Medication: Aspirin 0.9 1.2 4.2 0.3 -0.6 -2.1 0.2
Medication: Gliclazide 1.4 1.6 3.5 -0.6 -1.9 1.1 -1.3
Illnesses of father: None of the above (group 1) 0.4 0.5 1.9 1.4 0.0 0.3 -0.2
Smoking status: Current 0.8 1.2 2.1 -0.7 -1.5 -0.9 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 1.8 -1.2 0.3 -1.3 -1.4
Whole body water mass 1.2 7.0 24.4 -0.1 -1.6 4.9 -1.0
Leg predicted mass (right) 1.2 6.6 19.8 -0.6 -2.0 4.5 -1.6
Arm fat mass (left) 1.1 4.3 7.0 -1.7 -2.4 1.3 -2.6
Number of self-reported non-cancer illnesses 2.1 3.6 6.4 -1.4 -2.5 -1.5 -1.9
Average weekly champagne plus white wine intake 0.6 0.9 2.3 -1.5 0.3 0.5 0.9
Miserableness 0.3 0.5 0.7 0.2 -0.8 -0.7 0.8
Guilty feelings 0.3 0.5 0.9 0.9 0.2 0.3 1.0
Wears glasses or contact lenses 0.2 0.2 0.6 0.2 -0.6 0.7 -0.1
Ever taken oral contraceptive pill 0.6 0.6 1.9 -0.2 0.3 -0.7 1.4
Hearing aid user 0.8 0.9 2.6 0.9 1.6 0.3 0.5
Mother’s age at death 0.3 0.4 1.3 1.1 0.1 0.1 0.5
Financial situation satisfaction 0.3 0.4 0.7 -0.4 -0.3 -0.8 -0.7
Tinnitus: Yes, now most or all of the time 2.0 2.3 5.7 1.3 1.4 0.3 2.4
Commuting to job workplace: Public transport 1.6 1.9 3.3 -1.4 -1.8 -0.3 -1.5
Eye problems/disorders: Glaucoma 1.5 1.8 2.7 -0.2 -1.6 -1.6 1.4
Medication: Blood pressure 0.9 1.8 2.8 -1.7 -1.0 -1.0 -1.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 0.3 -0.3 -0.4 -1.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 -0.8 0.8 -1.0 -0.1
High cholesterol (Self-reported) 1.5 2.6 9.1 0.4 -0.9 -3.0 0.7
Medication: Bendroflumethiazide 2.2 3.4 8.9 -0.9 -1.9 -3.0 0.5
Medication: Paracetamol 0.5 0.8 2.0 0.6 0.6 1.4 -0.7
Medication: Lisinopril 1.0 1.3 3.7 0.9 -0.6 -1.9 -0.4
Medication: Atorvastatin 1.0 1.3 2.5 0.8 1.0 -1.0 1.6
Illnesses of father: High blood pressure 0.5 0.6 2.0 0.1 0.1 -0.7 1.4
Alcohol drinker status: Never 0.6 0.7 2.3 0.3 0.2 1.5 -0.5
Ever smoked 0.1 0.2 0.6 0.8 -0.1 -0.3 -0.2
Basal metabolic rate 1.3 7.0 22.4 -0.4 -1.9 4.7 -1.4
Leg fat percentage (left) 1.2 4.3 9.2 -2.1 -1.9 -0.3 -3.0
Arm fat-free mass (left) 1.3 6.4 22.2 -0.2 -1.5 4.7 -1.1
Number of operations (self-reported) 0.1 0.1 0.3 0.1 -0.5 0.5 -0.1
Average weekly beer plus cider intake 1.8 2.6 4.1 1.6 2.0 1.2 1.5
Irritability 0.2 0.3 0.5 0.7 -0.7 0.2 0.5
Risk taking 0.2 0.4 0.7 -0.1 -0.4 0.8 0.8
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.8 0.0 -0.5 1.4 -0.4
Fractured/broken bones in last 5 years 0.3 0.4 1.0 0.2 -0.1 -1.0 0.6
Age started oral contraceptive pill 0.4 0.6 1.3 -0.8 -0.5 -0.1 -1.1
Diastolic blood pressure, automated reading 1.7 5.2 13.0 -2.4 -3.6 -0.7 -1.3
Ever depressed for a whole week 1.6 2.0 5.2 1.3 -0.0 2.3 -1.1
Unable to work because of sickness or disability 0.6 0.7 1.4 1.2 0.7 -0.3 0.9
Commuting to job workplace: Cycle 1.4 1.6 4.1 2.0 -0.9 0.0 1.3
Myopia 0.5 0.8 1.8 1.1 -0.3 0.1 1.3
Vascular/heart problems diagnosed by doctor 1.0 2.7 6.3 0.9 2.5 1.2 1.5
Cholesterol lowering medication 0.6 0.9 2.6 -1.6 0.2 -1.0 0.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.9 0.7 -1.4 0.1 0.4
Pain experienced in last month 0.5 0.8 1.8 0.6 -0.3 -0.9 1.4
Supplements: Calcium 0.6 0.7 2.1 -1.5 -0.4 -0.5 -0.5
Basal cell carcinoma (self-reported) 1.6 1.8 6.0 -1.0 -0.6 0.2 -2.4
Heart attack/myocardial infarction (self-reported) 1.8 2.3 6.4 2.5 -0.7 -0.7 1.4
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.9 1.4 0.2 1.0 -0.1
Heart disease (siblings) 0.6 0.8 2.2 -0.2 -0.5 -0.8 -1.5
Alcohol drinker status: Previous 0.8 0.9 1.3 -0.4 -1.1 1.0 -1.1
Pack years of smoking 0.7 1.0 2.1 -0.5 -1.3 -1.4 0.4
Impedance of whole body 0.5 2.4 7.0 -0.3 -1.3 -2.6 0.8
Leg fat mass (left) 1.0 3.8 6.7 -1.6 -2.0 1.3 -2.6
Arm predicted mass (left) 1.2 6.1 20.5 -0.5 -1.6 4.5 -1.1