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chr5:76,597,461-80,648,873

Best TWAS P=5.25e-21 · Best GWAS P=2.14e-22 conditioned to 0.0383

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3B1	0.02	0.00	blup	126	0.01	1.8e-02	-9.7	-9.4	5.2e-21	0.85	0.02	0.90	TRUE
8	GTEx	Pituitary	LHFPL2	0.38	0.02	lasso	9	0.04	4.0e-02	3.3	-7.7	1.1e-14	0.50	0.04	0.52	TRUE
3	GTEx	Adrenal Gland	DHFR	0.47	0.22	lasso	10	0.28	1.1e-10	5.3	6.3	2.4e-10	0.04	0.00	1.00	TRUE
5	GTEx	Esophagus Muscularis	PAPD4	0.10	0.06	lasso	3	0.06	1.9e-04	6.0	-6.2	7.5e-10	-0.01	0.00	1.00	TRUE
10	GTEx	Stomach	ARSB	0.19	0.01	lasso	7	0.04	6.6e-03	-3.8	-6.0	1.6e-09	0.13	0.10	0.34	TRUE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DMGDH	0.03	0.02	lasso	5	0.02	3.1e-03	5.7	-5.3	9.9e-08	-0.05	0.01	0.93	TRUE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3B1	0.05	0.02	blup	126	0.03	5.0e-04	5.9	-8.6	5.6e-18	0.81	0.02	0.92	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP3B1	0.08	0.01	enet	20	0.02	9.7e-04	-9.5	-6.8	7.6e-12	0.60	0.01	0.87	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AP3B1	0.16	0.06	enet	18	0.09	2.2e-05	5.4	-6.8	9.5e-12	0.52	0.06	0.36	FALSE
14	YFS	Blood	DHFR	0.02	0.00	blup	499	0.01	2.3e-04	-3.9	6.2	7.5e-10	0.08	0.17	0.56	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARSB	0.12	0.06	blup	183	0.09	3.0e-10	4.2	-5.9	4.4e-09	0.01	0.78	0.21	FALSE
6	GTEx	Esophagus Muscularis	DHFR	0.34	0.22	enet	34	0.38	6.3e-24	3.7	5.8	6.9e-09	0.06	0.06	0.93	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DHFR	0.13	0.04	enet	19	0.09	6.6e-06	-3.8	5.6	1.6e-08	0.06	0.02	0.91	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3B1	0.05	0.03	lasso	3	0.04	4.4e-05	5.4	-5.6	2.2e-08	0.38	0.40	0.30	FALSE
11	GTEx	Testis	LHFPL2	0.18	-0.01	enet	21	0.10	2.1e-05	2.9	5.6	2.8e-08	-0.26	0.10	0.18	FALSE
24	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DHFR	0.26	0.25	blup	65	0.27	3.4e-11	5.3	5.5	3.2e-08	0.04	0.00	0.99	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHFR	0.20	0.18	enet	24	0.22	8.4e-24	5.3	5.5	3.7e-08	0.04	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	DHFR	0.31	0.19	enet	22	0.33	7.2e-33	5.3	5.5	3.8e-08	0.04	0.00	1.00	FALSE
12	METSIM	Adipose	AP3B1	0.07	0.01	blup	556	0.02	2.4e-04	4.6	-5.5	4.4e-08	0.54	0.09	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DHFR	0.55	0.40	bslmm	503	0.65	4.9e-106	-3.9	5.4	5.8e-08	0.06	0.60	0.29	FALSE
13	YFS	Blood	AP3B1	0.25	0.22	lasso	9	0.23	2.6e-74	5.3	-5.4	6.5e-08	0.30	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHFR	0.32	0.29	enet	31	0.41	2.0e-50	-3.9	5.4	8.2e-08	0.05	0.54	0.32	FALSE
7	GTEx	Muscle Skeletal	DHFR	0.37	0.42	enet	51	0.54	1.7e-62	-3.8	5.3	9.8e-08	0.05	0.63	0.25	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	DHFR	0.12	0.02	lasso	16	0.07	7.4e-05	-3.7	5.3	1.5e-07	0.05	0.31	0.41	FALSE
4	GTEx	Brain Hypothalamus	DHFR	0.39	0.31	lasso	16	0.35	5.7e-09	-3.8	5.2	1.7e-07	0.05	0.22	0.71	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BHMT	0.33	0.34	bslmm	414	0.39	7.6e-50	4.1	-5.2	2.3e-07	-0.04	0.93	0.06	FALSE