Hub : Genes

PAPD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.2250	0.0730	3.0e-04	0.054	NA	0.073	NA	0.102	1.4e-03	NA	2.4e-04	NA	1.5e-05
2	GTEx	Esophagus Muscularis	0.1010	0.0450	8.8e-03	0.060	NA	0.031	NA	0.058	1.5e-04	NA	5.5e-03	NA	1.9e-04
3	GTEx	Nerve Tibial	0.1059	0.0412	3.5e-03	0.093	NA	0.054	NA	0.072	4.1e-07	NA	1.1e-04	NA	8.1e-06
4	YFS	Blood	0.0626	0.0175	2.0e-07	0.044	0.026	0.037	0.043	0.043	3.7e-14	4.5e-09	3.3e-12	4.8e-14	6.7e-14
5	TCGA	Breast Invasive Carcinoma	0.0193	0.0108	5.6e-03	0.004	0.010	0.012	NA	0.008	3.5e-02	2.7e-03	1.1e-03	NA	6.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.1	1.8	4.3	-1.8	-1.1	0.3	-0.4	2.1
Bipolar Disorder or Schizophrenia	1.7	4.0	8.5	-2.9	-1.8	-0.7	-0.6	2.7
Depressed Affect (Nagel 2018)	1.2	2.5	4.7	1.1	1.9	1.4	2.2	-1.0
Depression (Nagel 2018)	3.2	4.8	10.4	1.8	2.5	0.5	1.9	-3.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	0.0	0.9	0.6	0.9	-1.0
Neuroticism (Nagel 2018)	1.6	3.8	6.6	1.6	2.6	1.0	2.2	-2.1
Schizophrenia (2018)	1.2	2.5	5.3	-2.3	-1.5	-1.1	-0.5	1.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.3	-0.8	-0.6	-0.5	-0.1
Worry (Nagel 2018)	0.5	1.1	2.1	0.8	1.5	0.6	0.8	-1.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	0.3	-0.5	1.4	-0.6	1.2
Alzheimer’s Disease (in father)	1.6	1.8	3.8	1.9	0.7	1.1	0.8	-1.6
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	1.7	0.1	1.1	0.1	-0.7
Crohns Disease (2017)	0.3	0.7	1.9	-1.2	-0.5	-1.4	-0.3	-0.1
Irritable Bowel Disease (IBD)	0.8	1.9	4.4	-1.8	-0.8	-2.1	-0.9	0.6
Ulcerative Colitis (UC)	1.2	2.3	5.2	-1.8	-0.9	-2.3	-1.1	1.1
Major Depression (MDD)	0.5	0.6	1.5	0.0	0.6	0.1	1.2	-1.1
Reaction Time	0.4	0.7	2.7	-0.4	-0.5	0.6	-0.2	1.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-0.6	0.8	0.3	0.8	-1.0
Breast Cancer	0.5	1.2	3.4	-0.3	-1.8	0.3	-0.7	1.4
Ovarian Cancer	1.1	1.4	4.7	2.2	1.0	0.9	0.6	-0.6
Prostate Cancer	0.1	0.2	0.7	-0.1	0.2	0.8	0.1	-0.3
Age at First Birth	0.3	0.5	1.1	-0.1	-0.7	-0.5	-0.7	1.0
Bipolar Disorder (2011)	3.2	3.1	6.5	-2.5	-1.5	0.0	-0.8	2.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	0.4	0.7	0.8	1.1	-0.4
Coronary Artery Disease (CAD)	1.1	1.3	2.8	-1.7	-0.6	-0.8	-0.7	1.4
Crohns Disease (2012)	0.2	0.3	0.6	0.2	0.8	0.4	0.5	-0.7
Mean Putamen Volume	0.2	0.2	0.8	-0.3	0.2	-0.3	0.1	-0.9
Fasting Glucose	0.3	0.4	1.1	0.6	1.1	0.3	0.5	-0.2
HbA1C	0.6	0.7	2.1	-0.8	-0.5	-1.4	0.1	-0.5
HDL Cholesterol	2.9	4.8	6.2	-2.3	-2.5	-2.1	-1.9	2.3
LDL Cholesterol	0.4	0.6	0.9	-1.0	-0.7	-0.9	-0.8	0.1
Lupus	0.3	0.4	1.1	-0.5	0.2	-0.6	0.6	-1.1
Neuroticism (2016)	1.8	2.6	3.9	-1.9	-1.5	-0.9	-1.4	2.0
Primary Biliary Cirrhosis	0.3	0.4	0.9	-1.0	0.3	-0.0	0.8	0.6
Rheumatoid Arthritis	0.2	0.3	0.4	-0.7	-0.3	-0.4	0.5	0.6
Schizophrenia (2014)	0.9	2.1	4.4	-1.8	-1.5	-0.2	-0.4	2.1
Triglycerides	0.5	0.9	2.1	-0.3	0.4	-1.4	0.3	-1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	-0.4	0.8	-0.8	0.3	-0.7
Ulcerative Colitis	0.9	1.3	2.6	-1.2	-0.9	-1.6	-0.8	1.0
Blood Eosinophil Count	0.0	0.2	0.6	0.4	-0.5	-0.8	0.3	0.3
Blood Platelet Count	0.1	0.6	2.4	-1.5	0.2	-0.3	-0.3	0.7
Blood Red Count	0.2	1.6	5.2	0.6	1.1	-0.3	1.0	-2.3
Blood White Count	0.1	0.6	1.0	0.4	0.9	-0.3	0.9	-1.0
Heel T-Score	0.4	2.9	6.9	2.1	1.5	0.5	1.0	-2.6
BMI	1.1	6.3	8.4	2.9	2.5	2.6	2.4	-2.0
Height	2.3	44.5	75.0	-5.7	-8.7	-5.7	-6.7	6.1
Waist Hip Ratio (WHR)	0.4	1.6	3.6	0.3	1.9	0.7	1.9	-0.6
Systolic Blood Pressure	0.2	0.8	1.7	0.4	0.8	0.6	1.3	-1.0
Smoking Status	0.1	0.3	0.9	-0.1	0.6	0.9	0.1	0.5
Allergy or Eczema	0.2	0.6	1.5	0.6	0.6	0.7	0.6	-1.2
Cardiovascular Disease	0.7	2.5	5.1	0.9	1.8	1.2	2.3	-1.3
Hypothyroidism (self reported)	0.4	0.9	1.3	-1.1	-0.8	-1.2	-1.1	0.2
Respiratory disease	0.5	1.1	2.2	1.5	0.7	0.3	1.3	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	-0.5	-0.9	-1.4	-0.7	0.1
Lung FEV1/FVC ratio	0.4	2.3	5.5	-1.6	-0.9	-1.0	-2.3	1.1
Lung FVC	0.3	1.4	2.7	1.6	1.3	1.6	0.3	-0.1
Neuroticism	1.1	2.6	4.7	0.8	2.2	0.8	2.0	-1.7
Chronotype (morning person)	0.2	0.4	1.3	1.2	-0.1	0.4	-0.6	-0.1
Hair Pigment	0.0	1.0	2.1	0.3	1.5	-0.0	1.1	-1.2
Tanning	0.0	0.4	0.9	0.7	-0.6	-0.2	-0.9	0.5
Hand grip strength (left)	0.4	1.1	2.1	-0.6	-1.4	-1.4	-0.7	1.0
Number of treatments/medications taken	0.1	0.1	0.4	0.1	0.1	0.6	0.4	0.4
Average weekly spirits intake	1.0	1.3	2.8	0.2	-1.2	0.4	-1.7	1.4
Sensitivity / hurt feelings	5.5	9.3	13.8	3.6	3.7	2.4	2.6	-2.8
Frequency of depressed mood in last 2 weeks	3.3	4.7	7.0	1.6	2.6	0.9	2.5	-2.7
Hearing difficulty/problems: Yes	0.8	1.3	2.5	1.3	1.2	0.4	0.6	-1.6
Relative age of first facial hair	4.3	8.8	12.1	-2.3	-3.5	-3.3	-3.2	2.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.4	1.2	-0.6	0.3	-0.9	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.8	0.4	0.3	1.4	1.1	-0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	1.0	0.8	0.6	0.8	-1.1
Systolic blood pressure, automated reading	0.6	1.7	3.5	1.2	1.0	1.4	1.9	-0.7
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	4.5	-2.0	-2.1	-2.1	-1.6	1.4
Angina	3.5	4.6	9.1	-2.3	-2.2	-0.8	-1.7	3.0
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.7	-0.3	-0.4	-0.1	0.9
Vitamin and mineral supplements	0.1	0.2	0.5	0.0	0.7	0.1	0.6	0.1
Supplements: Zinc	0.2	0.3	0.6	-0.8	-0.5	-0.3	-0.6	0.2
Medication: Co-codamol	0.7	0.8	2.1	1.0	0.3	-0.9	0.3	-1.4
Medication: Metformin	2.5	3.5	5.9	-0.9	-2.4	-1.6	-2.1	2.0
Diabetes (father)	0.1	0.1	0.3	-0.3	-0.1	-0.5	0.6	0.1
Diabetes (mother)	0.7	0.9	1.7	1.1	0.7	0.6	1.3	-0.9
Severe depression (siblings)	0.8	0.9	1.5	1.2	0.7	1.0	-0.1	-1.2
Pack years adult smoking proportion	1.0	1.6	6.0	-1.1	-0.7	-2.5	-0.6	-0.0
Impedance of leg (right)	0.3	1.5	4.5	-1.5	-0.7	-2.1	-0.5	0.0
Leg fat-free mass (left)	0.7	3.8	8.4	-1.0	-2.9	-1.3	-2.1	1.8
Trunk fat percentage	0.1	0.4	1.1	0.1	0.2	0.7	1.0	0.6
Hand grip strength (right)	0.4	1.0	1.6	-0.8	-1.3	-1.1	-0.4	1.2
Townsend deprivation index at recruitment	0.4	0.5	1.1	0.2	-0.8	-0.0	-1.1	0.9
Current tobacco smoking	0.9	1.4	4.0	2.0	0.5	1.1	0.1	-1.3
Average weekly fortified wine intake	0.9	1.0	3.6	0.6	0.1	1.9	0.0	1.0
Maternal smoking around birth	0.7	1.1	2.7	0.2	-0.7	-1.4	-1.6	0.1
Fed-up feelings	0.4	0.7	1.0	0.8	0.9	1.0	1.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	5.2	1.5	2.2	0.9	1.8	-2.3
Relative age voice broke	2.5	3.8	6.0	-2.1	-1.8	-2.5	-1.6	1.6
Taking other prescription medications	0.1	0.2	0.8	-0.9	-0.2	-0.4	0.0	0.3
Age when periods started (menarche)	0.6	1.4	3.3	-1.8	-0.9	-0.5	-1.2	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.8	0.7	0.4	-0.6	-0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.3	2.1	1.7	1.0	-0.0	-1.6
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.9	0.0	-0.9	-1.4	-1.4	-0.4
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.1	-0.9	0.3	-1.4	0.7
Serious illness, injury or assault to yourself	3.6	4.3	7.6	2.3	2.1	2.8	1.9	-0.8
High blood pressure	0.2	0.6	1.5	0.8	0.3	1.2	1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.0	0.3	0.1	0.2	-0.8
Multivitamins +/- minerals	0.1	0.1	0.2	0.1	0.0	-0.1	0.5	-0.5
Stomach or abdominal pain in last month	1.2	1.5	2.3	-0.9	-1.5	-1.4	-1.3	1.0
Supplements: Glucosamine	0.1	0.1	0.3	0.3	0.3	0.6	0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-0.7	-0.8	-0.6	-1.0	0.7
Medication: Atenolol	2.0	2.5	6.5	-2.5	-1.2	-0.6	-0.2	2.1
Medication: Levothyroxine sodium	0.7	1.2	2.4	-1.5	-0.8	-1.4	-0.3	1.0
Sitting height	1.8	12.9	20.7	-2.8	-4.5	-4.4	-3.5	2.1
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	-0.5	-0.3	-1.0	0.1	0.3
High blood pressure (mother)	1.0	1.4	4.1	0.7	1.1	2.0	1.0	0.4
Body mass index (BMI)	0.5	2.2	2.6	1.6	1.5	1.6	1.6	-1.0
Impedance of leg (left)	0.2	0.8	2.9	-1.0	-0.1	-1.7	0.1	-0.2
Leg predicted mass (left)	0.7	3.5	8.0	-0.9	-2.8	-1.2	-2.0	1.8
Trunk fat mass	0.1	0.3	0.7	-0.3	-0.6	-0.0	0.3	0.8
Waist circumference	0.3	1.2	2.2	0.9	1.2	0.9	1.5	-0.8
Number of incorrect matches in round	0.0	0.1	0.1	-0.1	0.3	0.2	-0.4	-0.0
Past tobacco smoking	1.6	2.9	6.3	1.7	1.5	0.3	1.7	-2.5
Alcohol usually taken with meals	0.3	0.4	0.9	-0.1	0.7	0.8	1.0	-0.4
Nervous feelings	0.4	0.7	1.5	0.6	0.8	0.1	1.2	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.5	1.2	1.9	1.1	1.9	-1.7
Hearing difficulty/problems with background noise	0.7	1.1	3.0	1.4	0.7	0.0	-0.1	-1.7
Hair/balding pattern: Pattern 2	0.4	0.4	1.7	0.6	0.3	1.3	-0.0	-0.3
Had menopause	0.5	0.6	1.3	0.6	0.7	1.2	0.9	-0.4
Had other major operations	1.3	1.6	2.5	1.3	1.0	1.3	1.6	-1.0
Forced vital capacity (FVC)	0.0	0.2	0.3	0.4	-0.1	-0.2	-0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.1	2.0	1.4	0.7	-0.4	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	0.0	-0.1	-0.7	-0.3	-1.2
Qualifications: None of the above	0.0	0.1	0.2	0.5	-0.2	0.1	0.3	-0.0
Financial difficulties in last 2 years	0.8	1.1	1.6	1.1	1.3	0.6	1.2	-0.8
Mouth/teeth dental problems	1.1	1.7	2.7	-1.6	-1.5	-1.6	-0.9	0.4
Heart attack	0.3	0.4	1.2	0.4	0.4	1.1	-0.4	0.7
Allergy	0.0	0.1	0.2	-0.4	0.2	-0.4	-0.2	0.0
Pain all over the body in last month	0.6	0.6	1.3	0.2	0.2	-1.2	0.7	-1.1
Diabetes (self-reported)	0.9	1.3	2.3	-1.3	-1.5	-1.0	-1.0	0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.4	1.0	0.3	0.3	-0.4
Medication: Ramipril	1.1	1.5	3.7	-1.1	-0.8	-0.3	-1.3	1.9
Medication: Simvastatin	0.4	0.6	1.2	0.5	0.5	1.1	1.1	0.2
Fluid intelligence score	0.0	0.1	0.3	-0.5	-0.0	0.2	0.3	0.2
Illnesses of siblings	0.1	0.2	0.5	-0.4	0.1	-0.2	0.7	-0.5
Neuroticism score	0.5	1.1	2.1	0.5	1.4	0.7	1.5	-0.8
Weight	0.1	0.5	1.5	-0.1	-1.2	-0.4	-0.5	0.7
Impedance of arm (right)	0.2	0.9	1.5	-1.2	-0.6	-1.0	-0.7	1.0
Arm fat percentage (right)	0.4	1.4	2.3	1.0	1.3	1.3	1.5	-0.6
Trunk fat-free mass	0.7	4.3	9.7	-1.0	-3.1	-1.8	-2.5	1.1
Hip circumference	0.0	0.1	0.2	0.3	-0.5	-0.3	-0.1	-0.1
Time employed in main current job	0.6	0.7	2.2	-0.3	1.5	0.2	0.2	-0.9
Alcohol intake versus 10 years previously	3.8	5.7	10.3	-2.4	-2.1	-3.2	-1.9	2.1
Father’s age at death	0.3	0.4	0.9	-0.7	-0.0	-1.0	0.2	-0.6
Worrier / anxious feelings	0.1	0.2	0.4	0.2	0.5	0.5	0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.5	0.5	0.4	0.9	-0.3
Falls in the last year	4.7	6.4	7.2	2.7	2.7	2.6	2.2	-2.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.4	0.6	-1.1	0.3	-1.1
Number of live births	2.9	4.2	8.2	-1.2	-2.9	-1.2	-2.0	2.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.6	-0.3	-0.9	-0.8	-1.6	1.1
Pulse rate	0.1	0.1	0.3	-0.3	0.1	0.2	0.6	0.1
Happiness	0.7	0.9	2.2	1.3	0.6	1.5	0.5	-0.3
Noisy workplace	0.2	0.3	0.5	0.5	0.5	-0.1	0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.5	0.7	1.6	1.4	1.5	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	1.3	0.5	1.5	0.7	-0.3
Mouth/teeth dental problems: Dentures	1.8	3.1	4.7	2.2	1.9	1.7	1.4	-1.5
Asthma	0.5	0.9	2.4	1.6	0.2	0.7	1.2	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.5	1.3	0.9	0.4	1.0	-1.9
Medication: Cholesterol lowering	0.7	1.2	3.1	-1.1	-0.9	-0.5	-0.7	1.7
Depression (self-reported)	0.3	0.4	1.3	-0.5	-0.3	-1.1	-0.3	-0.4
Medication: Lansoprazole	1.0	1.1	2.1	-0.5	-1.4	-1.3	-1.2	0.4
Prospective memory result	0.4	0.5	1.0	0.7	0.7	0.8	0.2	-1.0
Lung cancer (father)	0.5	0.6	1.3	0.8	0.7	0.8	1.1	-0.2
Illnesses of mother	0.5	0.6	1.8	-0.1	-0.4	-1.3	-0.9	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.8	0.1	-0.8	-0.4	-1.3	0.7
Pulse wave Arterial Stiffness index	3.5	4.0	4.9	-2.1	-2.0	-2.2	-1.9	1.9
Impedance of arm (left)	0.5	2.5	4.2	-2.1	-1.4	-1.4	-1.0	1.9
Arm fat mass (right)	0.1	0.3	0.6	0.5	0.2	0.8	0.6	0.0
Trunk predicted mass	0.7	4.3	9.7	-1.1	-3.1	-1.8	-2.5	1.1
Standing height	2.2	22.0	37.9	-3.8	-6.2	-4.5	-4.7	3.9
Length of working week for main job	1.6	1.7	4.5	-0.9	-1.4	-2.1	-1.2	0.3
Exposure to tobacco smoke at home	0.5	0.6	1.8	-1.3	-0.5	0.1	-0.3	0.8
Breastfed as a baby	1.3	1.6	2.6	-1.6	-1.3	-0.2	-1.3	1.5
Tense / ‘highly strung’	0.4	0.7	1.6	0.4	0.8	-1.0	0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	5.9	0.6	0.6	-0.7	0.3	-2.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.9	-0.4	-0.5	0.3	-0.4	1.4
Birth weight of first child	0.1	0.2	0.5	-0.4	-0.7	0.3	-0.5	0.5
Peak expiratory flow (PEF)	0.9	2.1	3.9	-1.0	-1.5	-1.5	-2.0	1.0
Pulse wave reflection index	0.1	0.2	0.3	-0.3	0.6	-0.4	-0.2	-0.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	1.6	0.7	1.2	0.7	-0.8
Loud music exposure frequency	2.6	2.8	6.8	1.8	1.4	1.3	0.7	-2.6
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	6.2	1.6	2.5	2.0	2.2	-1.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	1.0	0.3	0.7	-0.1	0.3
Blood clot in the leg (DVT)	0.9	1.2	2.7	0.5	-1.5	-0.4	-1.6	0.7
Medication: Paracetamol	0.4	0.6	1.3	0.6	0.7	0.4	0.9	-1.1
Headache pain in last month	0.9	1.6	2.9	1.7	1.3	1.3	0.6	-1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	0.8	0.3	-0.2	0.1	-1.3
Glaucoma (self-reported)	0.3	0.4	1.3	0.1	-0.1	1.1	0.2	0.8
Gout (self-reported)	0.6	0.8	1.5	-0.9	-1.2	-1.2	-0.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	-1.2	-0.7	-1.0	-0.8	0.8
Medication: Amlodipine	0.2	0.3	0.5	-0.6	-0.0	0.0	0.6	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.3	-0.2	-0.1	0.4	0.5
Birth weight	0.3	0.7	2.4	0.8	0.6	1.5	0.5	-0.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.0	-0.0	-0.3	-1.4	-0.6	-0.4
High blood pressure (siblings)	0.1	0.2	0.4	0.3	0.2	0.7	0.0	0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.9	0.9	-0.2	0.0	-0.5	0.3
Body fat percentage	0.1	0.6	1.7	0.4	0.6	0.8	1.3	-0.0
Leg fat percentage (right)	0.2	0.8	2.0	0.3	1.0	0.2	1.4	-1.0
Arm fat-free mass (right)	0.7	3.6	8.8	-1.1	-3.0	-1.5	-1.9	1.5
Exposure to tobacco smoke outside home	1.0	1.3	3.0	-1.4	-1.0	-0.5	-0.4	1.7
Comparative body size at age 10	3.4	9.4	15.1	3.9	3.0	3.0	2.6	-2.7
Number of full brothers	0.2	0.3	0.4	-0.6	0.5	0.3	0.7	-0.6
Worry too long after embarrassment	0.1	0.2	0.5	0.0	0.7	0.2	0.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.6	5.8	1.6	2.2	0.9	2.4	-1.9
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	1.4	0.9	0.2	0.9	-0.8
Number of children fathered	1.4	1.5	3.2	0.8	1.4	0.7	1.8	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.7	-0.9	-1.0	-0.1	-0.6	2.2
Age at first live birth	0.7	1.3	2.9	-0.7	-1.2	-1.4	-1.7	0.2
Pulse wave peak to peak time	2.8	3.3	4.0	2.0	1.7	2.0	1.7	-1.6
Health satisfaction	0.7	0.9	1.6	1.2	0.7	0.2	1.3	-0.8
Shortness of breath walking on level ground	0.7	0.8	2.9	1.7	0.5	0.5	0.7	-0.3
Qualifications: College or University degree	0.1	0.5	1.9	0.3	0.4	1.4	0.4	0.1
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.1	0.3	-0.5	0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.4	-0.3	-0.4	-0.5
Emphysema/chronic bronchitis	1.6	1.8	4.0	0.1	1.9	0.5	2.0	-1.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.3	-0.0	0.3	-0.1	0.5
Neck or shoulder pain in last month	0.6	0.9	1.4	0.1	-0.9	0.9	-1.1	1.2
Medication: Blood pressure	0.3	0.6	1.2	-1.1	-0.7	-0.4	-0.4	1.0
Angina (self-reported)	4.5	5.9	9.7	-2.6	-2.6	-1.4	-2.1	3.1
Migraine (self-reported)	0.8	1.0	1.6	-1.2	-1.3	-1.0	-1.1	0.3
Medication: Ibuprofen	1.2	1.4	2.7	1.6	0.9	1.0	0.9	-1.3
Medication: Allopurinol	0.6	0.8	2.1	-0.8	-1.0	-1.4	-0.4	-0.1
Medication: Omeprazole	0.3	0.3	0.7	0.1	0.2	0.4	0.8	0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.5	0.6	0.9	0.5	1.2	-0.7
Mean time to correctly identify matches	0.3	0.5	1.4	-0.3	-0.7	0.4	-0.6	1.2
Heart disease (mother)	0.5	0.6	1.2	0.6	0.3	1.1	1.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.6	0.3	-0.2	0.2	-0.6
Whole body fat mass	0.0	0.1	0.1	0.1	-0.3	0.2	0.4	0.4
Leg fat mass (right)	0.0	0.1	0.2	-0.0	-0.4	-0.4	0.2	0.0
Arm predicted mass (right)	0.6	3.1	7.9	-1.0	-2.8	-1.4	-1.7	1.3
Pulse rate, automated reading	0.1	0.2	0.5	-0.1	0.4	0.7	0.6	0.1
Alcohol intake frequency.	0.7	1.7	4.0	1.0	1.2	-0.7	1.2	-2.0
Comparative height size at age 10	0.4	2.3	4.8	-0.7	-2.2	-1.5	-1.6	1.2
Number of full sisters	0.7	0.8	3.0	-0.8	-0.5	0.2	-0.2	1.7
Suffer from ‘nerves’	0.7	1.1	3.0	0.6	0.9	-0.1	1.0	-1.7
Overall health rating	0.4	0.9	1.6	1.1	0.8	0.3	0.9	-1.3
Chest pain or discomfort	0.1	0.2	0.8	-0.2	0.1	0.1	-0.9	0.5
Had major operations	0.5	0.6	1.2	-1.1	-0.5	-0.5	-0.9	0.4
Age at last live birth	0.0	0.1	0.1	0.2	0.2	0.1	-0.4	0.3
Family relationship satisfaction	0.3	0.3	0.8	0.9	0.5	0.6	0.3	0.2
Leg pain on walking	0.3	0.3	1.3	1.1	0.0	0.6	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.4	1.8	1.8	1.0	1.0	-1.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.9	1.0	0.3	0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	4.8	-1.9	-1.2	-2.2	-1.7	0.3
Medication: Aspirin	0.4	0.5	1.1	-0.3	-1.0	-0.5	-0.6	0.9
Supplements: Vitamin C	0.6	0.7	1.1	0.1	-0.9	0.9	-1.1	0.8
Knee pain experienced in last month	1.9	2.9	4.7	2.2	1.7	2.0	1.3	-1.3
Hypertension (Self-reported)	0.5	1.3	2.8	1.2	0.8	1.7	1.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.5	0.0	-0.1	-0.1	0.6
Illnesses of father: Heart disease	1.5	2.1	4.0	-2.0	-1.0	-1.8	-1.1	1.1
Illnesses of siblings: Diabetes	1.3	1.6	5.5	0.0	-0.7	-2.3	-1.4	0.2
Smoking status: Previous	2.1	3.2	7.3	-2.3	-1.3	-0.6	-1.1	2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.6	-0.5	-1.1	-0.5	-0.4	1.3
Whole body fat-free mass	0.6	3.6	8.5	-0.9	-2.9	-1.5	-2.1	1.3
Leg fat-free mass (right)	0.6	2.9	6.8	-0.8	-2.6	-1.0	-1.9	1.7
Arm fat percentage (left)	0.3	1.0	2.1	0.6	1.0	1.2	1.4	-0.3
Average weekly red wine intake	1.8	2.7	4.8	1.9	1.7	2.2	1.4	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.8	-0.4	-0.0	0.3	0.7
Mood swings	0.1	0.2	0.6	-0.1	0.8	-0.0	0.4	-0.4
Loneliness, isolation	0.4	0.5	1.3	1.1	0.4	1.1	-0.1	0.1
Long-standing illness, disability or infirmity	0.3	0.4	0.7	0.6	-0.5	0.3	-0.8	0.8
Ever had bowel cancer screening	0.1	0.1	0.5	0.1	-0.1	-0.7	0.1	-0.0
Diabetes diagnosed by doctor	1.2	1.9	3.1	-1.4	-1.8	-1.4	-1.3	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.1	-0.1	-0.5	-0.9	-0.4
Friendships satisfaction	0.7	0.9	2.3	0.5	1.5	0.6	1.2	-0.5
Qualifications: nursing, teaching	0.2	0.4	1.0	-1.0	-0.1	0.3	0.3	0.8
Commuting to job workplace: Walk	0.4	0.5	1.0	0.6	0.0	1.0	1.0	-0.2
Eye problems/disorders: Cataract	0.4	0.5	0.9	0.8	0.7	0.9	0.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.2	-0.3	0.6	0.2	0.3
Medication for cholesterol	0.4	0.6	1.5	0.4	0.1	-0.6	-0.9	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.3	-0.1	0.4	-0.0	0.6
Back pain experienced in last month	0.7	1.0	2.3	1.5	0.2	-0.6	-0.6	-1.3
Mineral and other dietary supplements	1.5	2.0	2.5	1.6	1.4	1.3	1.3	-1.5
Breast cancer (self-reported)	0.5	0.6	1.6	0.0	0.7	0.9	1.3	-0.1
Asthma (self-reported)	0.3	0.6	1.8	1.3	0.2	0.5	0.9	-0.1
Osteoporosis (self-reported)	0.8	1.0	2.6	0.7	0.9	1.6	1.0	0.3
Osteoarthritis (self-reported)	1.4	1.8	2.6	1.2	1.6	1.1	1.0	-1.6
Medication: Aspirin	0.4	0.5	0.9	-0.7	-0.9	-0.5	-0.3	1.0
Medication: Gliclazide	3.7	4.2	4.9	-2.2	-2.0	-1.8	-2.2	1.9
Illnesses of father: None of the above (group 1)	0.8	1.0	3.3	0.5	1.0	1.8	0.6	0.1
Smoking status: Current	0.7	1.0	2.9	1.7	0.5	1.1	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.0	1.7	1.4	0.5	0.3	-0.9
Whole body water mass	0.6	3.6	8.6	-0.9	-2.9	-1.4	-2.2	1.4
Leg predicted mass (right)	0.6	3.2	7.2	-0.8	-2.7	-1.0	-1.9	1.8
Arm fat mass (left)	0.1	0.3	0.7	0.5	0.2	0.9	0.8	-0.0
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	-0.1	-0.2	1.0	0.3	0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.8	0.4	-0.5	0.2	0.4
Miserableness	0.4	0.7	1.4	0.1	1.0	0.1	1.2	-1.0
Guilty feelings	1.8	2.8	5.4	2.3	1.6	1.6	1.4	-1.2
Wears glasses or contact lenses	2.0	2.3	3.3	-1.8	-1.8	-0.8	-1.2	1.7
Ever taken oral contraceptive pill	2.7	3.1	4.0	-2.0	-1.8	-1.9	-1.4	1.5
Hearing aid user	0.1	0.1	0.3	0.3	0.3	0.6	-0.1	-0.0
Mother’s age at death	0.3	0.4	1.5	0.4	0.4	0.3	0.1	-1.2
Financial situation satisfaction	0.2	0.2	0.6	-0.2	-0.2	-0.5	-0.8	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.9	-0.7	-0.4	-0.8	1.1
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.3	0.7	0.3	0.5	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	2.0	0.3	0.6	1.4	0.8	0.3
Medication: Blood pressure	0.2	0.5	1.2	-0.6	-0.7	0.4	0.3	1.1
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.1	1.2	1.5	1.0	1.4	-2.0
Supplements: Fish oil (including cod liver oil)	2.2	2.9	4.1	-1.8	-1.7	-2.0	-1.3	1.6
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.2	0.0	0.7	0.7	0.9
Medication: Bendroflumethiazide	2.5	3.8	6.1	1.7	1.9	2.5	2.2	-1.3
Medication: Paracetamol	2.2	3.4	4.9	1.7	1.9	1.5	2.2	-1.8
Medication: Lisinopril	0.7	1.0	2.6	0.3	1.0	1.6	1.1	-0.0
Medication: Atorvastatin	0.1	0.1	0.3	0.2	0.2	0.5	0.0	0.2
Illnesses of father: High blood pressure	0.7	0.8	1.5	0.7	0.7	0.6	1.2	-1.1
Alcohol drinker status: Never	1.3	1.5	3.3	1.8	1.3	1.4	0.4	-0.7
Ever smoked	0.5	0.9	1.6	-0.3	-1.0	0.6	-1.2	1.1
Basal metabolic rate	0.5	2.7	6.6	-0.7	-2.6	-1.2	-1.8	1.2
Leg fat percentage (left)	0.3	1.1	2.6	0.6	1.1	0.4	1.6	-1.0
Arm fat-free mass (left)	0.3	1.7	4.9	-0.3	-2.2	-0.7	-1.6	0.9
Number of operations (self-reported)	0.2	0.3	0.8	-0.1	0.7	0.2	-0.1	-0.9
Average weekly beer plus cider intake	0.6	0.9	2.9	1.7	0.6	1.0	-0.1	0.2
Irritability	0.5	0.9	2.8	-1.1	-0.5	-1.7	-0.4	0.3
Risk taking	0.1	0.2	0.4	0.5	-0.2	0.6	-0.1	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	-0.2	-0.5	-1.2	-1.3	-0.5
Fractured/broken bones in last 5 years	3.5	4.5	6.8	1.9	2.5	1.7	1.9	-2.6
Age started oral contraceptive pill	0.9	1.1	3.5	-1.9	0.0	-1.2	0.8	-0.2
Diastolic blood pressure, automated reading	0.8	2.4	2.9	1.7	1.7	1.4	1.6	-1.4
Ever depressed for a whole week	0.9	1.2	3.1	0.8	1.0	0.0	1.0	-1.8
Unable to work because of sickness or disability	0.6	0.7	1.6	1.0	0.7	-0.8	0.1	-1.3
Commuting to job workplace: Cycle	1.1	1.3	3.2	-1.1	-1.1	-1.8	-1.0	0.0
Myopia	0.9	1.3	2.3	1.5	1.2	1.3	0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	-0.4	-0.3	-1.2	-1.0	-0.4
Cholesterol lowering medication	0.2	0.3	0.5	0.2	-0.3	0.7	0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.3	-0.3	-0.4	-0.0	0.3	1.1
Pain experienced in last month	0.7	1.2	3.0	-1.7	-0.2	-0.1	0.6	1.6
Supplements: Calcium	0.4	0.4	1.3	-1.1	-0.7	-0.3	-0.3	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	0.3	0.4	1.5	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.5	0.5	1.2	-0.3	0.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.9	0.4	-1.6	-0.5	-1.7	0.8
Heart disease (siblings)	0.7	0.8	2.3	-0.9	-0.1	-1.5	-0.8	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.1	-0.3	0.5	-0.3
Pack years of smoking	1.6	2.4	7.7	-1.6	-1.1	-2.8	-0.9	0.2
Impedance of whole body	0.2	1.3	2.2	-1.5	-0.8	-1.3	-0.5	1.2
Leg fat mass (left)	0.0	0.1	0.2	0.2	-0.1	-0.2	0.5	-0.1
Arm predicted mass (left)	0.3	1.7	4.9	-0.2	-2.2	-0.9	-1.5	0.7