TWAS hub - PAPD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.2250	0.0730	3.0e-04	0.054	NA	0.073	NA	0.102	1.4e-03	NA	2.4e-04	NA	1.5e-05
2	GTEx	Esophagus Muscularis	0.1010	0.0450	8.8e-03	0.060	NA	0.031	NA	0.058	1.5e-04	NA	5.5e-03	NA	1.9e-04
3	GTEx	Nerve Tibial	0.1059	0.0412	3.5e-03	0.093	NA	0.054	NA	0.072	4.1e-07	NA	1.1e-04	NA	8.1e-06
4	YFS	Blood	0.0626	0.0175	2.0e-07	0.044	0.026	0.037	0.043	0.043	3.7e-14	4.5e-09	3.3e-12	4.8e-14	6.7e-14
5	TCGA	Breast Invasive Carcinoma	0.0193	0.0108	5.6e-03	0.004	0.010	0.012	NA	0.008	3.5e-02	2.7e-03	1.1e-03	NA	6.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Sensitivity / hurt feelings	5.5	9.3	13.8	3.6	3.7	2.4	2.6	-2.8
Falls in the last year	4.7	6.4	7.2	2.7	2.7	2.6	2.2	-2.4
Angina (self-reported)	4.5	5.9	9.7	-2.6	-2.6	-1.4	-2.1	3.1
Relative age of first facial hair	4.3	8.8	12.1	-2.3	-3.5	-3.3	-3.2	2.2
Alcohol intake versus 10 years previously	3.8	5.7	10.3	-2.4	-2.1	-3.2	-1.9	2.1
Medication: Gliclazide	3.7	4.2	4.9	-2.2	-2.0	-1.8	-2.2	1.9
Serious illness, injury or assault to yourself	3.6	4.3	7.6	2.3	2.1	2.8	1.9	-0.8
Angina	3.5	4.6	9.1	-2.3	-2.2	-0.8	-1.7	3.0
Pulse wave Arterial Stiffness index	3.5	4.0	4.9	-2.1	-2.0	-2.2	-1.9	1.9
Fractured/broken bones in last 5 years	3.5	4.5	6.8	1.9	2.5	1.7	1.9	-2.6
Comparative body size at age 10	3.4	9.4	15.1	3.9	3.0	3.0	2.6	-2.7
Frequency of depressed mood in last 2 weeks	3.3	4.7	7.0	1.6	2.6	0.9	2.5	-2.7
Depression (Nagel 2018)	3.2	4.8	10.4	1.8	2.5	0.5	1.9	-3.2
Bipolar Disorder (2011)	3.2	3.1	6.5	-2.5	-1.5	0.0	-0.8	2.5
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	4.5	-2.0	-2.1	-2.1	-1.6	1.4
HDL Cholesterol	2.9	4.8	6.2	-2.3	-2.5	-2.1	-1.9	2.3
Number of live births	2.9	4.2	8.2	-1.2	-2.9	-1.2	-2.0	2.4
Pulse wave peak to peak time	2.8	3.3	4.0	2.0	1.7	2.0	1.7	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.6	5.8	1.6	2.2	0.9	2.4	-1.9
Ever taken oral contraceptive pill	2.7	3.1	4.0	-2.0	-1.8	-1.9	-1.4	1.5
Loud music exposure frequency	2.6	2.8	6.8	1.8	1.4	1.3	0.7	-2.6
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	6.2	1.6	2.5	2.0	2.2	-1.7
Medication: Metformin	2.5	3.5	5.9	-0.9	-2.4	-1.6	-2.1	2.0
Relative age voice broke	2.5	3.8	6.0	-2.1	-1.8	-2.5	-1.6	1.6
Medication: Bendroflumethiazide	2.5	3.8	6.1	1.7	1.9	2.5	2.2	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	5.2	1.5	2.2	0.9	1.8	-2.3
Height	2.3	44.5	75.0	-5.7	-8.7	-5.7	-6.7	6.1
Standing height	2.2	22.0	37.9	-3.8	-6.2	-4.5	-4.7	3.9
Supplements: Fish oil (including cod liver oil)	2.2	2.9	4.1	-1.8	-1.7	-2.0	-1.3	1.6
Medication: Paracetamol	2.2	3.4	4.9	1.7	1.9	1.5	2.2	-1.8
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	4.8	-1.9	-1.2	-2.2	-1.7	0.3
Smoking status: Previous	2.1	3.2	7.3	-2.3	-1.3	-0.6	-1.1	2.7
Medication: Atenolol	2.0	2.5	6.5	-2.5	-1.2	-0.6	-0.2	2.1
Wears glasses or contact lenses	2.0	2.3	3.3	-1.8	-1.8	-0.8	-1.2	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.4	1.8	1.8	1.0	1.0	-1.8
Knee pain experienced in last month	1.9	2.9	4.7	2.2	1.7	2.0	1.3	-1.3
Neuroticism (2016)	1.8	2.6	3.9	-1.9	-1.5	-0.9	-1.4	2.0
Sitting height	1.8	12.9	20.7	-2.8	-4.5	-4.4	-3.5	2.1
Mouth/teeth dental problems: Dentures	1.8	3.1	4.7	2.2	1.9	1.7	1.4	-1.5
Average weekly red wine intake	1.8	2.7	4.8	1.9	1.7	2.2	1.4	-0.6
Guilty feelings	1.8	2.8	5.4	2.3	1.6	1.6	1.4	-1.2
Bipolar Disorder or Schizophrenia	1.7	4.0	8.5	-2.9	-1.8	-0.7	-0.6	2.7
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.1	1.2	1.5	1.0	1.4	-2.0
Neuroticism (Nagel 2018)	1.6	3.8	6.6	1.6	2.6	1.0	2.2	-2.1
Alzheimer’s Disease (in father)	1.6	1.8	3.8	1.9	0.7	1.1	0.8	-1.6
Past tobacco smoking	1.6	2.9	6.3	1.7	1.5	0.3	1.7	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.5	1.2	1.9	1.1	1.9	-1.7
Length of working week for main job	1.6	1.7	4.5	-0.9	-1.4	-2.1	-1.2	0.3
Emphysema/chronic bronchitis	1.6	1.8	4.0	0.1	1.9	0.5	2.0	-1.0
Pack years of smoking	1.6	2.4	7.7	-1.6	-1.1	-2.8	-0.9	0.2
Illnesses of father: Heart disease	1.5	2.1	4.0	-2.0	-1.0	-1.8	-1.1	1.1
Mineral and other dietary supplements	1.5	2.0	2.5	1.6	1.4	1.3	1.3	-1.5
Number of children fathered	1.4	1.5	3.2	0.8	1.4	0.7	1.8	-1.2
Osteoarthritis (self-reported)	1.4	1.8	2.6	1.2	1.6	1.1	1.0	-1.6
Had other major operations	1.3	1.6	2.5	1.3	1.0	1.3	1.6	-1.0
Breastfed as a baby	1.3	1.6	2.6	-1.6	-1.3	-0.2	-1.3	1.5
Illnesses of siblings: Diabetes	1.3	1.6	5.5	0.0	-0.7	-2.3	-1.4	0.2
Alcohol drinker status: Never	1.3	1.5	3.3	1.8	1.3	1.4	0.4	-0.7
Depressed Affect (Nagel 2018)	1.2	2.5	4.7	1.1	1.9	1.4	2.2	-1.0
Schizophrenia (2018)	1.2	2.5	5.3	-2.3	-1.5	-1.1	-0.5	1.8
Ulcerative Colitis (UC)	1.2	2.3	5.2	-1.8	-0.9	-2.3	-1.1	1.1
Stomach or abdominal pain in last month	1.2	1.5	2.3	-0.9	-1.5	-1.4	-1.3	1.0
Medication: Ibuprofen	1.2	1.4	2.7	1.6	0.9	1.0	0.9	-1.3
Diabetes diagnosed by doctor	1.2	1.9	3.1	-1.4	-1.8	-1.4	-1.3	0.9
Bipolar Disorder (2018)	1.1	1.8	4.3	-1.8	-1.1	0.3	-0.4	2.1
Ovarian Cancer	1.1	1.4	4.7	2.2	1.0	0.9	0.6	-0.6
Coronary Artery Disease (CAD)	1.1	1.3	2.8	-1.7	-0.6	-0.8	-0.7	1.4
BMI	1.1	6.3	8.4	2.9	2.5	2.6	2.4	-2.0
Neuroticism	1.1	2.6	4.7	0.8	2.2	0.8	2.0	-1.7
Mouth/teeth dental problems	1.1	1.7	2.7	-1.6	-1.5	-1.6	-0.9	0.4
Medication: Ramipril	1.1	1.5	3.7	-1.1	-0.8	-0.3	-1.3	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.5	1.3	0.9	0.4	1.0	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.7	-0.9	-1.0	-0.1	-0.6	2.2
Commuting to job workplace: Cycle	1.1	1.3	3.2	-1.1	-1.1	-1.8	-1.0	0.0
Average weekly spirits intake	1.0	1.3	2.8	0.2	-1.2	0.4	-1.7	1.4
Pack years adult smoking proportion	1.0	1.6	6.0	-1.1	-0.7	-2.5	-0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.3	2.1	1.7	1.0	-0.0	-1.6
High blood pressure (mother)	1.0	1.4	4.1	0.7	1.1	2.0	1.0	0.4
Medication: Lansoprazole	1.0	1.1	2.1	-0.5	-1.4	-1.3	-1.2	0.4
Exposure to tobacco smoke outside home	1.0	1.3	3.0	-1.4	-1.0	-0.5	-0.4	1.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.9	0.4	-1.6	-0.5	-1.7	0.8
Schizophrenia (2014)	0.9	2.1	4.4	-1.8	-1.5	-0.2	-0.4	2.1
Ulcerative Colitis	0.9	1.3	2.6	-1.2	-0.9	-1.6	-0.8	1.0
Current tobacco smoking	0.9	1.4	4.0	2.0	0.5	1.1	0.1	-1.3
Average weekly fortified wine intake	0.9	1.0	3.6	0.6	0.1	1.9	0.0	1.0
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.9	0.0	-0.9	-1.4	-1.4	-0.4
Diabetes (self-reported)	0.9	1.3	2.3	-1.3	-1.5	-1.0	-1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	5.9	0.6	0.6	-0.7	0.3	-2.4
Peak expiratory flow (PEF)	0.9	2.1	3.9	-1.0	-1.5	-1.5	-2.0	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	1.6	0.7	1.2	0.7	-0.8
Blood clot in the leg (DVT)	0.9	1.2	2.7	0.5	-1.5	-0.4	-1.6	0.7
Headache pain in last month	0.9	1.6	2.9	1.7	1.3	1.3	0.6	-1.2
Age started oral contraceptive pill	0.9	1.1	3.5	-1.9	0.0	-1.2	0.8	-0.2
Ever depressed for a whole week	0.9	1.2	3.1	0.8	1.0	0.0	1.0	-1.8
Myopia	0.9	1.3	2.3	1.5	1.2	1.3	0.8	-0.5
Irritable Bowel Disease (IBD)	0.8	1.9	4.4	-1.8	-0.8	-2.1	-0.9	0.6
Hearing difficulty/problems: Yes	0.8	1.3	2.5	1.3	1.2	0.4	0.6	-1.6
Severe depression (siblings)	0.8	0.9	1.5	1.2	0.7	1.0	-0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.1	2.0	1.4	0.7	-0.4	-1.4
Financial difficulties in last 2 years	0.8	1.1	1.6	1.1	1.3	0.6	1.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	1.3	0.5	1.5	0.7	-0.3
Migraine (self-reported)	0.8	1.0	1.6	-1.2	-1.3	-1.0	-1.1	0.3
Osteoporosis (self-reported)	0.8	1.0	2.6	0.7	0.9	1.6	1.0	0.3
Illnesses of father: None of the above (group 1)	0.8	1.0	3.3	0.5	1.0	1.8	0.6	0.1
Diastolic blood pressure, automated reading	0.8	2.4	2.9	1.7	1.7	1.4	1.6	-1.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	0.3	-0.5	1.4	-0.6	1.2
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	1.7	0.1	1.1	0.1	-0.7
Cardiovascular Disease	0.7	2.5	5.1	0.9	1.8	1.2	2.3	-1.3
Medication: Co-codamol	0.7	0.8	2.1	1.0	0.3	-0.9	0.3	-1.4
Diabetes (mother)	0.7	0.9	1.7	1.1	0.7	0.6	1.3	-0.9
Leg fat-free mass (left)	0.7	3.8	8.4	-1.0	-2.9	-1.3	-2.1	1.8
Maternal smoking around birth	0.7	1.1	2.7	0.2	-0.7	-1.4	-1.6	0.1
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.1	-0.9	0.3	-1.4	0.7
Medication: Levothyroxine sodium	0.7	1.2	2.4	-1.5	-0.8	-1.4	-0.3	1.0
Leg predicted mass (left)	0.7	3.5	8.0	-0.9	-2.8	-1.2	-2.0	1.8
Hearing difficulty/problems with background noise	0.7	1.1	3.0	1.4	0.7	0.0	-0.1	-1.7
Trunk fat-free mass	0.7	4.3	9.7	-1.0	-3.1	-1.8	-2.5	1.1
Happiness	0.7	0.9	2.2	1.3	0.6	1.5	0.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.5	0.7	1.6	1.4	1.5	-0.7
Medication: Cholesterol lowering	0.7	1.2	3.1	-1.1	-0.9	-0.5	-0.7	1.7
Trunk predicted mass	0.7	4.3	9.7	-1.1	-3.1	-1.8	-2.5	1.1
Arm fat-free mass (right)	0.7	3.6	8.8	-1.1	-3.0	-1.5	-1.9	1.5
Age at first live birth	0.7	1.3	2.9	-0.7	-1.2	-1.4	-1.7	0.2
Health satisfaction	0.7	0.9	1.6	1.2	0.7	0.2	1.3	-0.8
Shortness of breath walking on level ground	0.7	0.8	2.9	1.7	0.5	0.5	0.7	-0.3
Alcohol intake frequency.	0.7	1.7	4.0	1.0	1.2	-0.7	1.2	-2.0
Number of full sisters	0.7	0.8	3.0	-0.8	-0.5	0.2	-0.2	1.7
Suffer from ‘nerves’	0.7	1.1	3.0	0.6	0.9	-0.1	1.0	-1.7
Friendships satisfaction	0.7	0.9	2.3	0.5	1.5	0.6	1.2	-0.5
Back pain experienced in last month	0.7	1.0	2.3	1.5	0.2	-0.6	-0.6	-1.3
Smoking status: Current	0.7	1.0	2.9	1.7	0.5	1.1	-0.1	-0.9
Medication: Lisinopril	0.7	1.0	2.6	0.3	1.0	1.6	1.1	-0.0
Illnesses of father: High blood pressure	0.7	0.8	1.5	0.7	0.7	0.6	1.2	-1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	-0.2	-0.5	-1.2	-1.3	-0.5
Pain experienced in last month	0.7	1.2	3.0	-1.7	-0.2	-0.1	0.6	1.6
Heart disease (siblings)	0.7	0.8	2.3	-0.9	-0.1	-1.5	-0.8	-0.4
HbA1C	0.6	0.7	2.1	-0.8	-0.5	-1.4	0.1	-0.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	1.0	0.8	0.6	0.8	-1.1
Systolic blood pressure, automated reading	0.6	1.7	3.5	1.2	1.0	1.4	1.9	-0.7
Age when periods started (menarche)	0.6	1.4	3.3	-1.8	-0.9	-0.5	-1.2	1.1
Pain all over the body in last month	0.6	0.6	1.3	0.2	0.2	-1.2	0.7	-1.1
Time employed in main current job	0.6	0.7	2.2	-0.3	1.5	0.2	0.2	-0.9
Gout (self-reported)	0.6	0.8	1.5	-0.9	-1.2	-1.2	-0.1	0.6
Neck or shoulder pain in last month	0.6	0.9	1.4	0.1	-0.9	0.9	-1.1	1.2
Medication: Allopurinol	0.6	0.8	2.1	-0.8	-1.0	-1.4	-0.4	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.5	0.6	0.9	0.5	1.2	-0.7
Arm predicted mass (right)	0.6	3.1	7.9	-1.0	-2.8	-1.4	-1.7	1.3
Supplements: Vitamin C	0.6	0.7	1.1	0.1	-0.9	0.9	-1.1	0.8
Whole body fat-free mass	0.6	3.6	8.5	-0.9	-2.9	-1.5	-2.1	1.3
Leg fat-free mass (right)	0.6	2.9	6.8	-0.8	-2.6	-1.0	-1.9	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.0	1.7	1.4	0.5	0.3	-0.9
Whole body water mass	0.6	3.6	8.6	-0.9	-2.9	-1.4	-2.2	1.4
Leg predicted mass (right)	0.6	3.2	7.2	-0.8	-2.7	-1.0	-1.9	1.8
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.9	-0.7	-0.4	-0.8	1.1
Average weekly beer plus cider intake	0.6	0.9	2.9	1.7	0.6	1.0	-0.1	0.2
Unable to work because of sickness or disability	0.6	0.7	1.6	1.0	0.7	-0.8	0.1	-1.3
Worry (Nagel 2018)	0.5	1.1	2.1	0.8	1.5	0.6	0.8	-1.4
Major Depression (MDD)	0.5	0.6	1.5	0.0	0.6	0.1	1.2	-1.1
Breast Cancer	0.5	1.2	3.4	-0.3	-1.8	0.3	-0.7	1.4
Triglycerides	0.5	0.9	2.1	-0.3	0.4	-1.4	0.3	-1.4
Respiratory disease	0.5	1.1	2.2	1.5	0.7	0.3	1.3	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.8	0.4	0.3	1.4	1.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.8	0.7	0.4	-0.6	-0.1	-1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-0.7	-0.8	-0.6	-1.0	0.7
Body mass index (BMI)	0.5	2.2	2.6	1.6	1.5	1.6	1.6	-1.0
Had menopause	0.5	0.6	1.3	0.6	0.7	1.2	0.9	-0.4
Neuroticism score	0.5	1.1	2.1	0.5	1.4	0.7	1.5	-0.8
Asthma	0.5	0.9	2.4	1.6	0.2	0.7	1.2	-0.2
Lung cancer (father)	0.5	0.6	1.3	0.8	0.7	0.8	1.1	-0.2
Illnesses of mother	0.5	0.6	1.8	-0.1	-0.4	-1.3	-0.9	-0.6
Impedance of arm (left)	0.5	2.5	4.2	-2.1	-1.4	-1.4	-1.0	1.9
Exposure to tobacco smoke at home	0.5	0.6	1.8	-1.3	-0.5	0.1	-0.3	0.8
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	1.4	0.9	0.2	0.9	-0.8
Heart disease (mother)	0.5	0.6	1.2	0.6	0.3	1.1	1.1	0.2
Had major operations	0.5	0.6	1.2	-1.1	-0.5	-0.5	-0.9	0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.9	1.0	0.3	0.7	-0.7
Hypertension (Self-reported)	0.5	1.3	2.8	1.2	0.8	1.7	1.3	-0.4
Breast cancer (self-reported)	0.5	0.6	1.6	0.0	0.7	0.9	1.3	-0.1
Eye problems/disorders: Glaucoma	0.5	0.6	2.0	0.3	0.6	1.4	0.8	0.3
Ever smoked	0.5	0.9	1.6	-0.3	-1.0	0.6	-1.2	1.1
Basal metabolic rate	0.5	2.7	6.6	-0.7	-2.6	-1.2	-1.8	1.2
Irritability	0.5	0.9	2.8	-1.1	-0.5	-1.7	-0.4	0.3
Reaction Time	0.4	0.7	2.7	-0.4	-0.5	0.6	-0.2	1.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	0.4	0.7	0.8	1.1	-0.4
LDL Cholesterol	0.4	0.6	0.9	-1.0	-0.7	-0.9	-0.8	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	-0.4	0.8	-0.8	0.3	-0.7
Heel T-Score	0.4	2.9	6.9	2.1	1.5	0.5	1.0	-2.6
Waist Hip Ratio (WHR)	0.4	1.6	3.6	0.3	1.9	0.7	1.9	-0.6
Hypothyroidism (self reported)	0.4	0.9	1.3	-1.1	-0.8	-1.2	-1.1	0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	-0.5	-0.9	-1.4	-0.7	0.1
Lung FEV1/FVC ratio	0.4	2.3	5.5	-1.6	-0.9	-1.0	-2.3	1.1
Hand grip strength (left)	0.4	1.1	2.1	-0.6	-1.4	-1.4	-0.7	1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.4	1.2	-0.6	0.3	-0.9	0.3
Hand grip strength (right)	0.4	1.0	1.6	-0.8	-1.3	-1.1	-0.4	1.2
Townsend deprivation index at recruitment	0.4	0.5	1.1	0.2	-0.8	-0.0	-1.1	0.9
Fed-up feelings	0.4	0.7	1.0	0.8	0.9	1.0	1.0	-0.3
Nervous feelings	0.4	0.7	1.5	0.6	0.8	0.1	1.2	-0.9
Hair/balding pattern: Pattern 2	0.4	0.4	1.7	0.6	0.3	1.3	-0.0	-0.3
Medication: Simvastatin	0.4	0.6	1.2	0.5	0.5	1.1	1.1	0.2
Arm fat percentage (right)	0.4	1.4	2.3	1.0	1.3	1.3	1.5	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.4	0.6	-1.1	0.3	-1.1
Prospective memory result	0.4	0.5	1.0	0.7	0.7	0.8	0.2	-1.0
Tense / ‘highly strung’	0.4	0.7	1.6	0.4	0.8	-1.0	0.5	-1.3
Medication: Paracetamol	0.4	0.6	1.3	0.6	0.7	0.4	0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	-1.2	-0.7	-1.0	-0.8	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.0	-0.0	-0.3	-1.4	-0.6	-0.4
Comparative height size at age 10	0.4	2.3	4.8	-0.7	-2.2	-1.5	-1.6	1.2
Overall health rating	0.4	0.9	1.6	1.1	0.8	0.3	0.9	-1.3
Medication: Aspirin	0.4	0.5	1.1	-0.3	-1.0	-0.5	-0.6	0.9
Loneliness, isolation	0.4	0.5	1.3	1.1	0.4	1.1	-0.1	0.1
Commuting to job workplace: Walk	0.4	0.5	1.0	0.6	0.0	1.0	1.0	-0.2
Eye problems/disorders: Cataract	0.4	0.5	0.9	0.8	0.7	0.9	0.4	-0.6
Medication for cholesterol	0.4	0.6	1.5	0.4	0.1	-0.6	-0.9	-1.2
Medication: Aspirin	0.4	0.5	0.9	-0.7	-0.9	-0.5	-0.3	1.0
Miserableness	0.4	0.7	1.4	0.1	1.0	0.1	1.2	-1.0
Supplements: Calcium	0.4	0.4	1.3	-1.1	-0.7	-0.3	-0.3	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	0.3	0.4	1.5	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.5	0.5	1.2	-0.3	0.7
Crohns Disease (2017)	0.3	0.7	1.9	-1.2	-0.5	-1.4	-0.3	-0.1
Age at First Birth	0.3	0.5	1.1	-0.1	-0.7	-0.5	-0.7	1.0
Fasting Glucose	0.3	0.4	1.1	0.6	1.1	0.3	0.5	-0.2
Lupus	0.3	0.4	1.1	-0.5	0.2	-0.6	0.6	-1.1
Primary Biliary Cirrhosis	0.3	0.4	0.9	-1.0	0.3	-0.0	0.8	0.6
Lung FVC	0.3	1.4	2.7	1.6	1.3	1.6	0.3	-0.1
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.7	-0.3	-0.4	-0.1	0.9
Impedance of leg (right)	0.3	1.5	4.5	-1.5	-0.7	-2.1	-0.5	0.0
Waist circumference	0.3	1.2	2.2	0.9	1.2	0.9	1.5	-0.8
Alcohol usually taken with meals	0.3	0.4	0.9	-0.1	0.7	0.8	1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	0.0	-0.1	-0.7	-0.3	-1.2
Heart attack	0.3	0.4	1.2	0.4	0.4	1.1	-0.4	0.7
Father’s age at death	0.3	0.4	0.9	-0.7	-0.0	-1.0	0.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.6	-0.3	-0.9	-0.8	-1.6	1.1
Depression (self-reported)	0.3	0.4	1.3	-0.5	-0.3	-1.1	-0.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	0.8	0.3	-0.2	0.1	-1.3
Glaucoma (self-reported)	0.3	0.4	1.3	0.1	-0.1	1.1	0.2	0.8
Birth weight	0.3	0.7	2.4	0.8	0.6	1.5	0.5	-0.0
Medication: Blood pressure	0.3	0.6	1.2	-1.1	-0.7	-0.4	-0.4	1.0
Medication: Omeprazole	0.3	0.3	0.7	0.1	0.2	0.4	0.8	0.8
Mean time to correctly identify matches	0.3	0.5	1.4	-0.3	-0.7	0.4	-0.6	1.2
Family relationship satisfaction	0.3	0.3	0.8	0.9	0.5	0.6	0.3	0.2
Leg pain on walking	0.3	0.3	1.3	1.1	0.0	0.6	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.6	-0.5	-1.1	-0.5	-0.4	1.3
Arm fat percentage (left)	0.3	1.0	2.1	0.6	1.0	1.2	1.4	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	0.7	0.6	-0.5	0.3	-0.8	0.8
Asthma (self-reported)	0.3	0.6	1.8	1.3	0.2	0.5	0.9	-0.1
Mother’s age at death	0.3	0.4	1.5	0.4	0.4	0.3	0.1	-1.2
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.3	0.7	0.3	0.5	-0.8
Leg fat percentage (left)	0.3	1.1	2.6	0.6	1.1	0.4	1.6	-1.0
Arm fat-free mass (left)	0.3	1.7	4.9	-0.3	-2.2	-0.7	-1.6	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.3	-0.3	-0.4	-0.0	0.3	1.1
Arm predicted mass (left)	0.3	1.7	4.9	-0.2	-2.2	-0.9	-1.5	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	0.0	0.9	0.6	0.9	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.3	-0.8	-0.6	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-0.6	0.8	0.3	0.8	-1.0
Crohns Disease (2012)	0.2	0.3	0.6	0.2	0.8	0.4	0.5	-0.7
Mean Putamen Volume	0.2	0.2	0.8	-0.3	0.2	-0.3	0.1	-0.9
Rheumatoid Arthritis	0.2	0.3	0.4	-0.7	-0.3	-0.4	0.5	0.6
Blood Red Count	0.2	1.6	5.2	0.6	1.1	-0.3	1.0	-2.3
Systolic Blood Pressure	0.2	0.8	1.7	0.4	0.8	0.6	1.3	-1.0
Allergy or Eczema	0.2	0.6	1.5	0.6	0.6	0.7	0.6	-1.2
Chronotype (morning person)	0.2	0.4	1.3	1.2	-0.1	0.4	-0.6	-0.1
Supplements: Zinc	0.2	0.3	0.6	-0.8	-0.5	-0.3	-0.6	0.2
High blood pressure	0.2	0.6	1.5	0.8	0.3	1.2	1.0	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	-0.5	-0.3	-1.0	0.1	0.3
Impedance of leg (left)	0.2	0.8	2.9	-1.0	-0.1	-1.7	0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.4	1.0	0.3	0.3	-0.4
Impedance of arm (right)	0.2	0.9	1.5	-1.2	-0.6	-1.0	-0.7	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.5	0.5	0.4	0.9	-0.3
Noisy workplace	0.2	0.3	0.5	0.5	0.5	-0.1	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.8	0.1	-0.8	-0.4	-1.3	0.7
Hair/balding pattern: Pattern 4	0.2	0.5	1.9	-0.4	-0.5	0.3	-0.4	1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	1.0	0.3	0.7	-0.1	0.3
Medication: Amlodipine	0.2	0.3	0.5	-0.6	-0.0	0.0	0.6	0.7
Leg fat percentage (right)	0.2	0.8	2.0	0.3	1.0	0.2	1.4	-1.0
Number of full brothers	0.2	0.3	0.4	-0.6	0.5	0.3	0.7	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.6	0.3	-0.2	0.2	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.8	-0.4	-0.0	0.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.1	-0.1	-0.5	-0.9	-0.4
Qualifications: nursing, teaching	0.2	0.4	1.0	-1.0	-0.1	0.3	0.3	0.8
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	-0.1	-0.2	1.0	0.3	0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.8	0.4	-0.5	0.2	0.4
Financial situation satisfaction	0.2	0.2	0.6	-0.2	-0.2	-0.5	-0.8	-0.1
Medication: Blood pressure	0.2	0.5	1.2	-0.6	-0.7	0.4	0.3	1.1
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.2	0.0	0.7	0.7	0.9
Number of operations (self-reported)	0.2	0.3	0.8	-0.1	0.7	0.2	-0.1	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	-0.4	-0.3	-1.2	-1.0	-0.4
Cholesterol lowering medication	0.2	0.3	0.5	0.2	-0.3	0.7	0.5	0.6
Impedance of whole body	0.2	1.3	2.2	-1.5	-0.8	-1.3	-0.5	1.2
Prostate Cancer	0.1	0.2	0.7	-0.1	0.2	0.8	0.1	-0.3
Blood Platelet Count	0.1	0.6	2.4	-1.5	0.2	-0.3	-0.3	0.7
Blood White Count	0.1	0.6	1.0	0.4	0.9	-0.3	0.9	-1.0
Smoking Status	0.1	0.3	0.9	-0.1	0.6	0.9	0.1	0.5
Number of treatments/medications taken	0.1	0.1	0.4	0.1	0.1	0.6	0.4	0.4
Vitamin and mineral supplements	0.1	0.2	0.5	0.0	0.7	0.1	0.6	0.1
Diabetes (father)	0.1	0.1	0.3	-0.3	-0.1	-0.5	0.6	0.1
Trunk fat percentage	0.1	0.4	1.1	0.1	0.2	0.7	1.0	0.6
Taking other prescription medications	0.1	0.2	0.8	-0.9	-0.2	-0.4	0.0	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.0	0.3	0.1	0.2	-0.8
Multivitamins +/- minerals	0.1	0.1	0.2	0.1	0.0	-0.1	0.5	-0.5
Supplements: Glucosamine	0.1	0.1	0.3	0.3	0.3	0.6	0.1	-0.1
Trunk fat mass	0.1	0.3	0.7	-0.3	-0.6	-0.0	0.3	0.8
Illnesses of siblings	0.1	0.2	0.5	-0.4	0.1	-0.2	0.7	-0.5
Weight	0.1	0.5	1.5	-0.1	-1.2	-0.4	-0.5	0.7
Worrier / anxious feelings	0.1	0.2	0.4	0.2	0.5	0.5	0.6	-0.4
Pulse rate	0.1	0.1	0.3	-0.3	0.1	0.2	0.6	0.1
Arm fat mass (right)	0.1	0.3	0.6	0.5	0.2	0.8	0.6	0.0
Birth weight of first child	0.1	0.2	0.5	-0.4	-0.7	0.3	-0.5	0.5
Pulse wave reflection index	0.1	0.2	0.3	-0.3	0.6	-0.4	-0.2	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.3	-0.2	-0.1	0.4	0.5
High blood pressure (siblings)	0.1	0.2	0.4	0.3	0.2	0.7	0.0	0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.9	0.9	-0.2	0.0	-0.5	0.3
Body fat percentage	0.1	0.6	1.7	0.4	0.6	0.8	1.3	-0.0
Worry too long after embarrassment	0.1	0.2	0.5	0.0	0.7	0.2	0.1	-0.5
Qualifications: College or University degree	0.1	0.5	1.9	0.3	0.4	1.4	0.4	0.1
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.1	0.3	-0.5	0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.4	-0.3	-0.4	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.3	-0.0	0.3	-0.1	0.5
Pulse rate, automated reading	0.1	0.2	0.5	-0.1	0.4	0.7	0.6	0.1
Chest pain or discomfort	0.1	0.2	0.8	-0.2	0.1	0.1	-0.9	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.5	0.0	-0.1	-0.1	0.6
Mood swings	0.1	0.2	0.6	-0.1	0.8	-0.0	0.4	-0.4
Ever had bowel cancer screening	0.1	0.1	0.5	0.1	-0.1	-0.7	0.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.2	-0.3	0.6	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.3	-0.1	0.4	-0.0	0.6
Arm fat mass (left)	0.1	0.3	0.7	0.5	0.2	0.9	0.8	-0.0
Hearing aid user	0.1	0.1	0.3	0.3	0.3	0.6	-0.1	-0.0
Medication: Atorvastatin	0.1	0.1	0.3	0.2	0.2	0.5	0.0	0.2
Risk taking	0.1	0.2	0.4	0.5	-0.2	0.6	-0.1	0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.1	-0.3	0.5	-0.3
Blood Eosinophil Count	0.0	0.2	0.6	0.4	-0.5	-0.8	0.3	0.3
Hair Pigment	0.0	1.0	2.1	0.3	1.5	-0.0	1.1	-1.2
Tanning	0.0	0.4	0.9	0.7	-0.6	-0.2	-0.9	0.5
Number of incorrect matches in round	0.0	0.1	0.1	-0.1	0.3	0.2	-0.4	-0.0
Forced vital capacity (FVC)	0.0	0.2	0.3	0.4	-0.1	-0.2	-0.5	0.6
Qualifications: None of the above	0.0	0.1	0.2	0.5	-0.2	0.1	0.3	-0.0
Allergy	0.0	0.1	0.2	-0.4	0.2	-0.4	-0.2	0.0
Fluid intelligence score	0.0	0.1	0.3	-0.5	-0.0	0.2	0.3	0.2
Hip circumference	0.0	0.1	0.2	0.3	-0.5	-0.3	-0.1	-0.1
Whole body fat mass	0.0	0.1	0.1	0.1	-0.3	0.2	0.4	0.4
Leg fat mass (right)	0.0	0.1	0.2	-0.0	-0.4	-0.4	0.2	0.0
Age at last live birth	0.0	0.1	0.1	0.2	0.2	0.1	-0.4	0.3
Leg fat mass (left)	0.0	0.1	0.2	0.2	-0.1	-0.2	0.5	-0.1

Hub : Genes

PAPD4

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Trait associations