[Hub]/) : Traits : Mouth/teeth dental problems: Mouth ulcers :

chr3:45,262,393-47,544,003

Best TWAS P=1.56e-54 · Best GWAS P=2.81e-52 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous FYCO1 0.18 0.12 lasso 4 0.12 9.8e-10 -9.07 -9.4 3.7e-21 -0.35 0.99 0.00 FALSE
2 GTEx Artery Aorta FYCO1 0.14 0.02 enet 13 0.08 4.4e-05 -8.48 -7.0 3.6e-12 -0.28 0.77 0.03 FALSE
3 GTEx Artery Aorta LRRC2 0.08 0.00 enet 14 0.00 2.5e-01 5.59 7.7 1.7e-14 0.32 0.08 0.12 FALSE
4 GTEx Brain Cortex LRRC2 0.35 0.10 enet 29 0.15 6.6e-05 -0.63 5.5 3.2e-08 0.32 0.13 0.09 FALSE
5 GTEx Cells Transformed fibroblasts FYCO1 0.26 0.14 enet 14 0.22 3.9e-16 -7.64 -7.9 2.1e-15 -0.29 1.00 0.00 FALSE
6 GTEx Cells Transformed fibroblasts CCR1 0.13 0.07 lasso 6 0.07 8.9e-06 -8.95 -8.9 4.9e-19 -0.20 1.00 0.00 TRUE
7 GTEx Esophagus Gastroesophageal Junction FYCO1 0.15 0.13 lasso 5 0.13 2.8e-05 -5.21 -7.1 1.6e-12 -0.36 0.33 0.06 FALSE
8 GTEx Esophagus Mucosa FYCO1 0.17 0.08 lasso 3 0.15 2.2e-10 4.24 -7.3 3.7e-13 -0.27 1.00 0.00 FALSE
9 GTEx Esophagus Mucosa TMIE 0.09 0.01 lasso 5 0.01 5.3e-02 -4.28 7.0 2.9e-12 0.43 0.09 0.05 FALSE
10 GTEx Esophagus Muscularis FYCO1 0.17 0.06 lasso 8 0.08 1.7e-05 -9.07 -9.9 4.7e-23 -0.37 0.80 0.01 FALSE
11 GTEx Lung FYCO1 0.20 0.16 enet 17 0.16 4.4e-12 -9.07 -8.2 1.6e-16 -0.32 1.00 0.00 TRUE
12 GTEx Nerve Tibial FYCO1 0.26 0.24 enet 25 0.27 2.8e-19 -5.21 -6.2 4.9e-10 -0.38 1.00 0.00 FALSE
13 GTEx Skin Sun Exposed Lower leg FYCO1 0.17 0.08 lasso 8 0.19 1.5e-15 4.24 -6.4 1.3e-10 -0.31 1.00 0.00 FALSE
14 GTEx Thyroid FYCO1 0.20 0.13 lasso 9 0.13 2.0e-10 -8.48 -11.0 4.7e-28 -0.43 1.00 0.00 FALSE
15 GTEx Whole Blood CCR1 0.12 0.10 lasso 4 0.09 4.8e-09 -8.77 -10.6 2.6e-26 -0.44 0.99 0.00 FALSE
16 METSIM Adipose FYCO1 0.11 0.10 lasso 6 0.14 2.4e-20 -7.54 -7.4 9.9e-14 -0.27 1.00 0.00 FALSE
17 METSIM Adipose PRSS50 0.03 0.02 blup 365 0.02 1.3e-03 -2.97 7.3 2.5e-13 0.35 0.69 0.14 FALSE
18 NTR Blood CCR1 0.17 0.12 enet 34 0.19 3.7e-59 -12.10 -8.7 2.7e-18 -0.14 1.00 0.00 FALSE
19 NTR Blood CCR3 0.19 0.12 lasso 13 0.22 3.9e-69 -12.10 10.8 3.6e-27 0.39 1.00 0.00 FALSE
20 NTR Blood CXCR6 0.02 0.02 lasso 5 0.02 2.4e-06 -8.21 9.8 7.0e-23 0.34 0.96 0.01 FALSE
21 NTR Blood FYCO1 0.02 0.01 lasso 1 0.01 5.6e-05 5.68 5.7 1.4e-08 0.10 0.90 0.00 TRUE
22 YFS Blood CCR1 0.49 0.30 bslmm 457 0.38 2.0e-133 -8.80 -8.2 2.3e-16 -0.26 1.00 0.00 FALSE
23 YFS Blood CCR5 0.04 0.03 lasso 5 0.04 5.2e-13 -8.59 -7.4 1.3e-13 -0.68 1.00 0.00 TRUE
24 YFS Blood CXCR6 0.05 0.04 lasso 13 0.06 8.5e-19 -8.53 10.3 8.0e-25 0.35 1.00 0.00 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma FYCO1 0.06 0.05 blup 81 0.07 1.6e-13 4.00 -5.4 6.5e-08 -0.18 1.00 0.00 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma CCR1 0.08 0.01 blup 28 0.02 2.1e-02 -8.95 -12.0 2.1e-33 -0.36 0.01 0.24 TRUE
27 The Cancer Genome Atlas Colon Adenocarcinoma FYCO1 0.07 0.02 blup 79 0.04 1.5e-03 4.00 -5.2 1.6e-07 -0.30 0.05 0.38 FALSE
28 The Cancer Genome Atlas Glioblastoma Multiforme CCR3 0.23 0.13 enet 8 0.13 8.3e-05 -12.10 13.2 1.0e-39 0.48 0.04 0.42 FALSE
29 The Cancer Genome Atlas Glioblastoma Multiforme LTF 0.24 0.11 lasso 5 0.09 9.5e-04 4.38 5.5 3.0e-08 0.04 0.05 0.05 FALSE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FYCO1 0.08 0.01 blup 81 0.04 3.9e-05 3.58 -6.7 2.8e-11 -0.22 0.08 0.45 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCR3 0.07 0.00 blup 76 0.03 1.0e-04 -8.76 8.1 5.0e-16 0.17 0.10 0.03 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FYCO1 0.10 0.10 blup 79 0.10 7.1e-11 -9.07 -9.1 8.2e-20 -0.34 0.00 1.00 FALSE
33 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FYCO1 0.07 0.02 lasso 6 0.02 1.4e-02 4.74 -6.6 5.3e-11 -0.26 0.01 0.74 FALSE
34 The Cancer Genome Atlas Lung Adenocarcinoma FYCO1 0.04 0.04 lasso 2 0.03 5.3e-04 -8.48 -8.6 9.1e-18 -0.29 0.01 0.96 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CCR1 0.03 0.02 blup 28 0.02 1.5e-03 -12.10 -12.2 2.4e-34 -0.40 0.00 0.94 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FYCO1 0.06 0.02 lasso 6 0.05 2.7e-06 3.19 -6.0 1.9e-09 -0.30 0.09 0.90 FALSE
37 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FYCO1 0.08 0.03 enet 12 0.04 8.1e-04 -5.26 -6.7 2.5e-11 -0.33 0.01 0.94 FALSE
38 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FYCO1 0.34 0.13 blup 78 0.18 1.1e-07 4.71 -6.5 8.0e-11 -0.34 0.09 0.64 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma CCR2 0.10 0.01 enet 15 0.05 7.1e-06 5.75 -12.2 2.7e-34 -0.78 0.01 0.51 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma CCR5 0.09 0.06 enet 5 0.08 2.8e-08 -8.59 -5.2 2.1e-07 -0.65 0.93 0.01 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma FYCO1 0.14 0.17 blup 81 0.18 2.7e-18 3.15 -6.5 9.2e-11 -0.24 1.00 0.00 FALSE
42 The Cancer Genome Atlas Rectum Adenocarcinoma CCR3 0.20 0.11 lasso 3 0.10 2.7e-03 15.20 15.6 1.6e-54 0.97 0.00 0.89 TRUE
43 The Cancer Genome Atlas Thyroid Carcinoma CCR3 0.07 0.01 blup 76 0.01 1.3e-02 -12.10 13.6 4.6e-42 0.53 0.03 0.14 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma FYCO1 0.16 0.10 enet 14 0.14 2.1e-13 3.15 -6.9 4.1e-12 -0.26 0.59 0.41 FALSE
45 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CCR5 0.12 0.04 blup 32 0.06 8.4e-03 -8.59 -5.3 1.2e-07 -0.63 0.00 0.42 FALSE