Hub : Genes

TMIE

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0930 0.0410 0.00850 0.009 NA 0.007 NA 0.012 0.08200 NA 9.6e-02 NA 0.0530
2 METSIM Adipose 0.0500 0.0230 0.00610 0.009 0.008 0.024 0.014 0.015 0.01400 1.7e-02 1.2e-04 3.1e-03 0.0021
3 ROSMAP Brain Pre-frontal Cortex 0.0924 0.0360 0.00036 0.022 0.050 0.041 0.052 0.029 0.00066 4.9e-07 5.1e-06 2.9e-07 0.0001
4 TCGA Breast Invasive Carcinoma 0.0291 0.0181 0.00140 0.007 0.010 0.010 NA 0.008 0.01400 3.2e-03 3.4e-03 NA 0.0069
5 TCGA Thyroid Carcinoma 0.0520 0.0230 0.00020 0.014 0.030 0.035 NA 0.020 0.01300 5.6e-04 2.2e-04 NA 0.0047

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 1.0 3.4 -0.2 0.7 1.9 0.3 0.9
Bipolar Disorder or Schizophrenia 0.6 1.4 3.0 0.7 1.5 -0.1 1.2 1.7
Depressed Affect (Nagel 2018) 0.7 1.5 3.8 -1.2 2.0 0.2 -0.4 1.3
Depression (Nagel 2018) 1.2 1.8 3.7 -0.3 1.6 -1.5 0.4 1.9
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 0.6 0.2 -0.5 0.4 0.1
Neuroticism (Nagel 2018) 0.2 0.5 1.1 0.0 1.0 -0.2 -1.0 0.6
Schizophrenia (2018) 0.9 1.9 2.7 1.1 1.3 -1.6 1.1 1.6
Schizophrenia vs Biploar Disorder 1.1 1.5 6.9 -0.2 0.5 -2.6 0.4 -0.5
Worry (Nagel 2018) 0.1 0.3 1.0 1.0 0.1 0.5 -0.2 -0.4
Alzheimer’s Disease (in mother) 0.4 0.4 0.7 -0.6 0.3 -0.7 0.9 0.7
Alzheimer’s Disease (in father) 0.8 0.8 3.8 0.3 0.1 0.2 2.0 0.5
Alzheimer’s Disease (including proxy) 0.1 0.2 0.7 -0.4 -0.0 -0.3 0.8 -0.0
Crohns Disease (2017) 0.6 1.4 3.7 1.9 0.0 1.7 -0.5 0.4
Irritable Bowel Disease (IBD) 1.3 3.0 10.4 0.8 -1.1 3.2 -1.6 -0.3
Ulcerative Colitis (UC) 2.2 4.1 12.3 -0.6 -1.6 3.5 -2.1 -0.8
Major Depression (MDD) 2.2 2.7 5.1 0.3 2.2 -2.2 -1.7 0.6
Reaction Time 0.8 1.6 7.4 0.2 -2.7 -0.5 0.1 -0.5
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.9 -0.5 1.7 -1.0 1.6 0.0
Breast Cancer 1.8 4.3 9.3 -1.0 1.0 -3.0 2.8 1.6
Ovarian Cancer 0.8 1.0 2.0 -1.3 0.8 -1.4 -0.8 0.0
Prostate Cancer 0.5 0.7 1.8 0.4 -0.8 -0.8 -1.3 -0.4
Age at First Birth 0.7 1.0 3.8 -0.1 1.0 -0.6 1.9 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 2.1 -0.3 1.5 0.9 -0.8 1.4
Coronary Artery Disease (CAD) 1.3 1.6 4.4 -2.1 0.4 0.5 -1.6 -0.8
Crohns Disease (2012) 0.5 0.7 1.9 1.2 -0.2 1.4 0.3 -0.3
Mean Putamen Volume 2.1 2.4 6.9 0.2 0.1 -0.8 2.1 2.6
Fasting Glucose 0.4 0.4 1.5 0.4 1.2 0.5 0.2 -0.4
HbA1C 0.3 0.3 0.7 0.8 -0.4 -0.4 -0.9 -0.2
HDL Cholesterol 0.5 0.9 2.0 0.8 -0.1 1.3 1.4 0.4
LDL Cholesterol 0.4 0.6 2.3 0.7 -1.5 -0.7 0.1 0.2
Lupus 2.1 3.2 7.6 -1.2 1.0 -1.5 1.9 2.8
Neuroticism (2016) 0.3 0.4 0.7 -0.4 0.6 -0.9 -0.6 0.7
Primary Biliary Cirrhosis 0.2 0.3 1.1 0.1 -0.5 -1.1 0.1 -0.1
Rheumatoid Arthritis 1.3 1.8 4.8 2.2 -0.8 -0.1 -1.1 -1.6
Schizophrenia (2014) 0.4 0.9 2.0 -0.5 1.4 -1.1 0.8 0.8
Triglycerides 1.3 2.1 5.5 -0.5 1.5 -2.3 -0.1 1.6
Type 2 Diabetes (T2D) (2012) 4.4 5.1 8.6 -2.5 -1.2 1.6 -2.9 -2.6
Ulcerative Colitis 1.4 2.1 4.9 -1.4 -0.8 2.2 -1.5 -0.8
Blood Eosinophil Count 0.6 4.6 14.7 3.8 -1.2 -1.4 -2.1 0.7
Blood Platelet Count 0.3 3.6 8.3 -0.5 0.2 2.9 -2.8 -1.4
Blood Red Count 0.3 2.5 6.4 -0.1 2.5 -1.5 1.8 0.9
Blood White Count 2.1 15.7 40.1 -2.5 -3.7 2.5 -6.3 -3.5
Heel T-Score 0.6 4.4 10.3 -0.6 -1.8 0.6 -3.2 -2.8
BMI 0.5 2.8 5.8 -1.4 2.3 1.1 0.1 2.4
Height 2.0 38.5 80.1 2.0 5.1 -8.9 6.9 5.9
Waist Hip Ratio (WHR) 2.0 9.1 16.4 -3.0 -3.2 1.6 -4.0 -2.6
Systolic Blood Pressure 0.3 1.3 2.7 -1.5 1.6 -1.0 -0.3 0.7
Smoking Status 0.2 0.4 1.5 1.2 -0.5 -0.4 0.5 0.2
Allergy or Eczema 0.6 1.6 4.4 0.9 2.1 -1.1 -1.0 0.8
Cardiovascular Disease 0.8 2.6 4.9 -1.7 -0.6 0.9 -2.2 -2.0
Hypothyroidism (self reported) 0.6 1.3 2.1 -1.4 0.9 -0.0 -1.4 -1.3
Respiratory disease 0.6 1.3 2.8 -1.1 0.1 -1.7 -0.9 1.4
Type 2 Diabetes (T2D) (2018) 1.9 3.5 8.1 -0.3 -1.0 0.9 -2.9 -2.7
Lung FEV1/FVC ratio 1.0 5.3 13.0 -0.3 1.1 -3.6 2.9 1.9
Lung FVC 0.2 0.9 3.2 0.7 -0.6 1.8 -0.7 -0.3
Neuroticism 0.3 0.6 1.2 0.2 -0.6 0.7 -1.1 -1.0
Chronotype (morning person) 0.6 1.4 2.7 -1.4 -0.8 1.1 -0.9 -1.6
Hair Pigment 0.1 3.7 9.9 3.1 0.3 -1.1 2.4 1.4
Tanning 0.0 0.3 1.0 1.0 -0.4 0.1 0.1 -0.4
Hand grip strength (left) 1.5 3.9 8.7 -0.4 2.3 -1.8 1.4 3.0
Number of treatments/medications taken 0.5 0.8 2.9 -1.7 0.6 0.7 0.4 0.5
Average weekly spirits intake 2.7 3.4 7.7 -2.1 0.8 0.2 2.8 2.0
Sensitivity / hurt feelings 1.1 1.9 6.4 0.4 -1.3 0.8 -2.5 -1.0
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.6 -0.9 -0.2 -0.3 0.2 1.2
Hearing difficulty/problems: Yes 0.5 0.7 1.0 0.6 -1.0 0.9 -1.0 -0.5
Relative age of first facial hair 0.1 0.3 1.1 -0.0 -1.1 0.3 -0.0 -0.3
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.4 0.2 -0.6 0.5 0.1 -0.2
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.2 0.7 -1.8 -0.0 -1.2 -1.1
Ever had hysterectomy (womb removed) 0.6 0.7 2.2 0.2 -1.5 0.0 -0.8 -0.8
Systolic blood pressure, automated reading 1.2 3.5 7.8 -0.5 2.0 -1.0 2.1 2.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 2.7 -1.6 -1.3 0.0 -1.3 -1.3
Angina 3.4 4.5 9.7 -2.3 -2.4 3.1 -0.5 -1.1
Medication for hormone replacement therapy 0.9 1.0 2.4 -0.7 0.3 -0.7 -1.6 1.2
Vitamin and mineral supplements 1.1 1.5 3.6 -1.1 -0.7 0.5 -1.4 -1.9
Supplements: Zinc 0.2 0.2 0.4 0.6 0.1 -0.5 -0.5 -0.4
Medication: Co-codamol 0.6 0.8 1.5 -0.5 -1.2 0.6 -0.8 -1.0
Medication: Metformin 1.1 1.5 1.9 -0.9 -1.1 1.4 -1.3 -1.4
Diabetes (father) 0.8 1.0 2.7 0.0 -1.3 -0.2 -1.6 -0.7
Diabetes (mother) 1.0 1.2 3.7 -1.9 0.2 -1.5 0.2 0.5
Severe depression (siblings) 0.1 0.2 0.3 0.5 -0.5 -0.0 -0.5 0.2
Pack years adult smoking proportion 0.6 1.0 3.8 -0.3 -0.7 0.3 0.6 2.0
Impedance of leg (right) 0.5 2.3 5.7 -0.8 -0.2 -2.4 -0.6 -2.2
Leg fat-free mass (left) 0.9 4.9 10.5 0.3 2.7 -1.7 2.0 3.2
Trunk fat percentage 0.1 0.5 1.3 -1.2 0.5 0.6 0.9 0.1
Hand grip strength (right) 1.8 4.9 7.3 -1.4 2.7 -2.0 2.0 2.7
Townsend deprivation index at recruitment 0.6 0.8 1.6 -1.0 -1.3 0.6 -0.8 -0.7
Current tobacco smoking 0.4 0.7 2.7 -1.6 0.2 0.8 0.0 0.4
Average weekly fortified wine intake 1.4 1.6 3.2 0.8 1.8 1.6 1.1 0.7
Maternal smoking around birth 2.8 4.1 11.9 1.5 1.9 -3.5 -0.3 1.6
Fed-up feelings 0.4 0.8 1.8 -1.3 0.3 0.4 0.4 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.0 -1.7 0.7 -0.7 -0.1 0.7
Relative age voice broke 1.1 1.7 3.9 0.1 -2.0 1.9 -0.5 -0.8
Taking other prescription medications 1.0 1.6 6.0 -2.5 -0.6 0.7 -0.8 -0.5
Age when periods started (menarche) 0.2 0.6 1.2 0.9 -0.0 -1.1 0.8 -0.3
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 5.6 -0.8 -0.1 -0.2 -1.4 -2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.7 0.2 -1.1 -1.4 -1.6 -0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.5 0.2 1.2 0.3 0.7 0.9
Qualifications: CSEs or equivalent 0.9 1.1 3.8 0.2 -0.2 -1.9 -0.9 1.0
Serious illness, injury or assault to yourself 1.2 1.4 3.2 -0.9 -1.8 0.9 -1.5 0.0
High blood pressure 0.3 0.8 1.5 -0.7 -1.1 0.9 -0.4 -1.2
Hayfever, allergic rhinitis or eczema 1.2 2.6 6.7 0.2 2.6 -2.0 -0.4 1.4
Multivitamins +/- minerals 2.2 2.9 5.0 1.6 1.2 -1.2 1.9 2.2
Stomach or abdominal pain in last month 0.6 0.8 2.8 -0.7 -1.7 0.7 -0.0 0.3
Supplements: Glucosamine 1.2 1.6 3.1 0.4 1.8 -0.9 1.2 1.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.3 1.2 -0.4 -0.4 -0.3 -0.4
Medication: Atenolol 2.6 3.2 7.3 -1.3 -1.2 2.7 -0.9 -2.2
Medication: Levothyroxine sodium 0.7 1.1 2.5 -1.2 0.4 -1.1 -1.6 -0.4
Sitting height 1.1 8.1 12.6 2.6 3.6 -2.0 3.4 2.3
Chronic bronchitis/emphysema (father) 0.6 0.7 2.6 -1.6 0.9 0.4 -0.2 0.3
High blood pressure (mother) 0.7 1.0 2.5 0.2 1.6 0.2 -0.2 -1.5
Body mass index (BMI) 0.3 1.3 2.9 -1.0 1.0 1.4 0.1 1.7
Impedance of leg (left) 0.4 1.9 5.3 -1.2 -0.2 -2.3 -0.7 -1.5
Leg predicted mass (left) 0.9 4.8 10.2 0.4 2.6 -1.6 2.0 3.2
Trunk fat mass 0.3 1.3 2.2 -0.9 1.5 -0.3 1.3 1.4
Waist circumference 0.2 0.8 1.9 -1.4 0.4 1.0 -1.0 0.3
Number of incorrect matches in round 0.4 0.7 1.3 0.7 -0.5 1.1 0.9 -0.7
Past tobacco smoking 0.4 0.8 1.7 -1.2 -0.4 1.3 -0.5 -0.6
Alcohol usually taken with meals 0.8 1.3 1.9 1.3 1.3 -1.4 -0.9 -0.7
Nervous feelings 0.4 0.7 1.2 0.7 -1.1 0.7 0.4 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.2 -1.2 -1.5 0.5 0.5 0.6
Hearing difficulty/problems with background noise 0.7 1.1 2.1 -0.6 -0.5 1.5 -0.9 -1.3
Hair/balding pattern: Pattern 2 0.6 0.7 2.2 -1.5 0.1 0.2 -0.1 -1.2
Had menopause 0.8 1.0 1.3 1.0 -1.1 1.1 0.7 0.9
Had other major operations 0.7 0.9 1.4 -0.6 1.1 -0.8 0.7 1.2
Forced vital capacity (FVC) 0.2 0.9 1.6 1.1 1.2 -1.3 -0.1 0.5
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.6 0.4 -1.5 -1.7 -2.2 -1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.3 -1.1 0.5 -0.1 -0.4 -0.4
Qualifications: None of the above 0.2 0.5 1.6 0.2 -1.2 0.4 0.9 0.0
Financial difficulties in last 2 years 0.7 0.9 2.4 0.3 0.2 -1.5 -0.5 1.3
Mouth/teeth dental problems 3.0 4.6 14.4 -3.8 2.3 -0.1 -1.3 -1.3
Heart attack 3.6 4.7 9.7 -2.6 -3.1 1.7 -1.8 -0.8
Allergy 1.0 2.4 5.0 0.9 -1.9 2.2 0.5 -1.5
Pain all over the body in last month 2.4 2.5 4.9 -1.2 -2.1 0.8 -2.2 -1.2
Diabetes (self-reported) 0.7 1.0 2.3 -0.3 -0.8 0.2 -1.5 -1.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.1 -1.0 0.9 -0.0 -0.4 0.7
Medication: Ramipril 2.5 3.2 6.0 -0.8 -2.4 2.5 -1.5 -1.0
Medication: Simvastatin 0.4 0.6 2.1 0.4 -0.8 1.5 0.2 -0.5
Fluid intelligence score 0.4 0.9 1.8 0.7 1.4 -0.8 1.2 -0.6
Illnesses of siblings 0.1 0.2 0.3 0.5 -0.5 0.4 0.1 -0.3
Neuroticism score 0.1 0.1 0.4 -0.0 -0.3 -0.1 -0.7 -0.2
Weight 1.0 5.0 10.8 -0.5 3.0 -1.5 1.7 3.3
Impedance of arm (right) 0.5 2.5 9.5 -0.5 -1.4 -0.4 0.7 -3.1
Arm fat percentage (right) 0.2 0.8 2.2 -1.2 0.6 1.5 0.3 0.2
Trunk fat-free mass 1.9 11.0 22.5 0.9 4.0 -3.4 2.0 4.7
Hip circumference 0.8 3.6 9.4 -0.5 3.1 -0.8 1.7 2.2
Time employed in main current job 0.5 0.5 1.9 0.8 -0.1 -0.3 1.4 -0.3
Alcohol intake versus 10 years previously 0.3 0.4 1.8 0.1 0.1 -1.3 -0.4 0.4
Father’s age at death 0.6 0.8 2.5 1.6 0.2 -0.8 -0.4 -0.7
Worrier / anxious feelings 0.4 0.7 1.4 1.0 -0.8 -0.4 -1.2 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.9 -0.1 -0.4 -0.5 0.0 0.9
Falls in the last year 1.6 2.2 6.2 -1.8 0.7 -0.9 0.2 2.5
Hair/balding pattern: Pattern 3 0.7 1.0 3.1 -1.0 -1.8 0.2 -1.0 0.2
Number of live births 0.4 0.5 1.9 -0.0 -0.7 1.4 0.5 0.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.9 0.8 1.1 -1.7 -0.0 0.3
Pulse rate 0.2 0.4 0.9 -0.0 1.0 -0.8 0.1 -0.4
Happiness 1.5 1.9 4.1 -1.6 0.3 -2.0 1.3 0.8
Noisy workplace 0.8 0.9 3.1 -1.8 0.0 -0.6 0.4 1.1
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.6 1.2 0.0 -1.6 -0.1 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 2.1 -0.6 -0.0 0.3 -1.4 -0.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.2 -0.1 -0.7 0.1 0.9 1.1
Asthma 1.3 2.6 8.2 -0.9 1.0 -2.9 -0.4 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.1 -1.1 -0.4 -0.1 -0.1 0.2
Medication: Cholesterol lowering 0.4 0.6 1.9 -0.8 -0.1 1.4 0.4 0.4
Depression (self-reported) 1.1 1.3 3.7 0.7 -0.4 0.5 1.4 1.9
Medication: Lansoprazole 1.7 2.0 6.6 -0.6 -1.1 0.9 -2.6 -0.9
Prospective memory result 0.5 0.6 0.9 -0.8 -0.9 -0.0 1.0 0.9
Lung cancer (father) 1.6 1.9 4.7 2.2 -1.3 1.4 1.1 0.4
Illnesses of mother 1.0 1.2 3.5 0.3 -0.3 -1.2 0.9 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.0 0.7 0.8 -1.0 0.0 0.4
Pulse wave Arterial Stiffness index 0.9 1.1 3.0 -0.9 -0.0 -1.7 0.9 0.9
Impedance of arm (left) 0.6 2.9 11.7 -0.4 -1.4 0.0 0.9 -3.4
Arm fat mass (right) 0.4 1.6 3.5 -1.0 1.7 0.2 0.9 1.9
Trunk predicted mass 1.9 11.0 22.3 0.9 4.0 -3.5 2.0 4.7
Standing height 1.9 19.2 39.3 1.0 4.8 -6.3 4.1 4.0
Length of working week for main job 0.6 0.7 2.2 -1.5 0.1 0.8 0.3 0.5
Exposure to tobacco smoke at home 1.4 1.6 2.8 -1.6 0.0 -1.4 0.7 1.7
Breastfed as a baby 0.6 0.8 2.0 0.3 1.0 -0.3 1.4 0.8
Tense / ‘highly strung’ 0.1 0.2 0.6 0.7 0.0 -0.6 0.3 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.4 0.0 0.2 0.0 -0.9 -1.2
Hair/balding pattern: Pattern 4 0.2 0.6 1.8 0.9 -0.1 1.3 0.1 -0.5
Birth weight of first child 1.8 3.3 6.4 0.7 2.1 -1.7 1.4 2.5
Peak expiratory flow (PEF) 0.7 1.7 6.1 2.5 0.1 -1.4 -0.7 0.5
Pulse wave reflection index 0.4 0.4 1.2 -1.1 -0.3 -0.3 0.2 0.9
Ever highly irritable/argumentative for 2 days 1.4 1.7 7.2 -2.7 -0.2 1.1 -0.2 0.2
Loud music exposure frequency 0.6 0.7 1.5 -1.2 -0.5 -0.5 -0.8 -0.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.2 0.6 0.5 -1.8 -0.5 1.2
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.6 1.4 -1.6 1.1 -0.1 0.2
Blood clot in the leg (DVT) 5.4 7.0 12.5 -1.0 -3.0 2.6 -2.5 -3.5
Medication: Paracetamol 0.8 1.3 2.7 0.8 0.1 -1.7 1.2 1.4
Headache pain in last month 0.3 0.6 2.1 0.5 -1.4 -0.2 -0.7 0.4
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 9.2 1.4 0.4 -3.0 -0.1 0.5
Glaucoma (self-reported) 1.2 1.4 4.8 -0.8 -0.7 0.9 -0.1 -2.2
Gout (self-reported) 0.4 0.6 1.0 -1.0 0.9 0.0 0.5 1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.9 -0.5 0.3 -0.5 -1.7 -0.9
Medication: Amlodipine 1.8 2.5 10.2 -3.2 1.4 -0.0 0.3 -0.3
Medication: Ventolin 100micrograms inhaler 1.4 1.8 3.0 -1.7 1.5 -1.7 0.2 1.0
Birth weight 1.2 2.5 5.5 0.6 1.2 -1.6 1.7 2.4
Chronic bronchitis/emphysema (mother) 0.6 0.8 1.9 0.5 -1.4 -0.5 -0.6 1.0
High blood pressure (siblings) 0.5 0.8 1.6 -0.2 1.3 -0.4 1.3 0.7
Forced vital capacity (FVC), Best measure 0.1 0.5 1.1 0.7 1.1 -0.7 -0.3 0.6
Body fat percentage 0.2 0.6 1.7 -1.3 0.6 0.9 0.3 0.1
Leg fat percentage (right) 0.2 0.7 1.6 -1.3 0.7 0.8 -0.7 0.1
Arm fat-free mass (right) 1.8 9.3 19.6 0.3 3.8 -3.1 1.7 4.4
Exposure to tobacco smoke outside home 1.6 2.1 6.0 -0.8 0.5 -1.8 0.6 2.5
Comparative body size at age 10 1.1 3.0 7.1 -0.5 2.0 -0.2 1.8 2.7
Number of full brothers 0.7 0.8 1.5 1.1 0.6 -0.3 1.0 1.2
Worry too long after embarrassment 0.6 1.0 4.3 -0.5 -0.5 -0.1 -2.1 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.5 0.3 0.7 0.3 -0.7 -0.1
Wheeze or whistling in the chest in last year 1.6 2.8 11.4 -3.4 -0.5 0.4 -0.1 1.5
Number of children fathered 2.6 2.9 9.4 0.1 1.1 -0.9 3.1 1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.8 -0.1 -0.7 0.9 0.3 0.4
Age at first live birth 2.0 3.6 8.7 0.9 2.5 -3.0 1.4 -0.2
Pulse wave peak to peak time 0.5 0.6 1.1 0.9 0.4 1.0 -0.7 -0.6
Health satisfaction 1.5 2.0 6.9 -2.6 0.6 -0.4 0.4 1.6
Shortness of breath walking on level ground 0.7 0.8 1.3 -1.1 -1.0 -0.5 -0.6 1.0
Qualifications: College or University degree 0.8 2.5 6.1 1.3 -0.1 -0.6 -2.1 -2.5
Eye problems/disorders: None of the above 1.5 1.8 5.4 2.3 0.3 -0.9 1.5 0.5
Mouth/teeth dental problems: Loose teeth 0.7 0.9 1.7 -0.1 1.1 -0.2 1.3 1.2
Emphysema/chronic bronchitis 1.1 1.3 3.8 -0.4 0.2 -1.1 1.0 2.0
Medication for pain relief, constipation, heartburn 0.5 0.8 1.7 0.6 1.3 -1.2 -0.7 0.0
Neck or shoulder pain in last month 0.4 0.6 1.4 -0.1 -1.2 1.1 0.0 0.6
Medication: Blood pressure 1.4 2.5 4.2 -1.9 -0.3 2.1 -1.1 -1.9
Angina (self-reported) 3.4 4.5 9.8 -2.3 -2.4 3.1 -0.7 -1.2
Migraine (self-reported) 0.3 0.4 0.8 0.9 -0.2 -0.0 -0.8 -0.6
Medication: Ibuprofen 0.2 0.3 1.0 -1.0 0.1 -0.1 0.5 0.4
Medication: Allopurinol 2.3 3.0 4.6 -0.7 1.8 -1.9 2.1 1.7
Medication: Omeprazole 0.4 0.5 1.5 -0.6 0.4 -0.5 0.4 1.2
Medication: Seretide 50 evohaler 2.4 2.8 4.9 -1.6 0.9 -1.1 2.1 2.2
Mean time to correctly identify matches 1.1 2.1 9.4 0.4 -3.1 -0.4 0.7 -0.6
Heart disease (mother) 1.4 1.7 2.9 0.6 -1.7 1.3 -1.2 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.2 -0.1 1.5 0.2 -1.0 -0.8
Whole body fat mass 0.4 1.5 2.5 -1.1 1.6 -0.3 1.1 1.6
Leg fat mass (right) 0.4 1.4 3.0 -1.2 1.6 0.0 0.3 1.7
Arm predicted mass (right) 1.6 8.3 17.6 0.6 3.5 -2.9 1.9 4.2
Pulse rate, automated reading 0.2 0.8 2.2 0.6 -0.3 0.1 -1.1 -1.5
Alcohol intake frequency. 0.5 1.3 2.3 -1.3 0.3 1.5 -1.0 -1.2
Comparative height size at age 10 2.2 11.9 25.4 -1.9 3.3 -5.0 2.4 3.7
Number of full sisters 0.9 1.1 3.2 0.6 -1.2 -0.3 0.4 1.8
Suffer from ‘nerves’ 0.8 1.2 4.6 2.1 -1.1 -0.1 -0.4 -0.4
Overall health rating 1.1 2.4 5.7 -1.9 -2.4 1.5 -0.8 0.2
Chest pain or discomfort 0.5 0.8 2.7 0.6 -1.6 0.4 -0.6 -0.4
Had major operations 0.6 0.7 2.7 0.4 -0.3 -1.7 0.5 0.6
Age at last live birth 1.7 2.4 4.0 1.4 2.0 -1.7 1.7 -0.0
Family relationship satisfaction 2.6 3.1 5.6 -1.8 1.5 -2.0 0.8 2.4
Leg pain on walking 2.4 3.0 6.6 -1.3 1.4 -2.6 0.1 2.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.0 -0.7 1.7 -0.8 0.8 0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 -0.7 0.3 0.3 0.2 -0.2
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.1 -0.3 1.3 -0.0 1.8 0.1
Medication: Aspirin 2.4 3.2 6.7 0.1 -2.3 2.6 0.0 -2.0
Supplements: Vitamin C 0.0 0.0 0.1 -0.3 0.1 0.3 -0.1 -0.1
Knee pain experienced in last month 0.4 0.7 1.9 -0.6 -0.4 0.3 -1.4 1.0
Hypertension (Self-reported) 0.7 1.9 3.0 -0.9 -1.6 1.4 -0.9 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 -0.7 -0.1 -0.7 1.1 0.9
Illnesses of father: Heart disease 3.6 5.0 7.2 -2.6 -1.1 1.8 -2.5 -2.7
Illnesses of siblings: Diabetes 0.3 0.4 1.4 -0.3 -1.2 0.4 0.2 -0.4
Smoking status: Previous 0.7 1.0 3.2 1.8 0.1 -1.2 0.5 0.3
Forced expiratory volume in 1-second (FEV1), predicted 3.4 7.0 11.4 -1.7 2.3 -2.6 3.0 3.4
Whole body fat-free mass 1.5 8.8 18.9 0.7 3.5 -2.9 2.0 4.3
Leg fat-free mass (right) 1.0 5.5 12.8 0.4 2.8 -1.6 2.0 3.6
Arm fat percentage (left) 0.3 1.0 3.2 -1.2 0.5 1.8 0.4 0.1
Average weekly red wine intake 0.5 0.7 1.6 1.3 0.2 -0.7 -0.5 -1.1
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.0 -0.7 1.4 0.2 -0.7 0.7
Mood swings 0.0 0.0 0.1 -0.3 0.0 0.3 -0.0 0.2
Loneliness, isolation 0.7 1.0 3.5 -1.0 0.3 0.1 -1.9 -0.7
Long-standing illness, disability or infirmity 0.4 0.7 1.6 -1.3 -0.6 0.2 -1.1 -0.2
Ever had bowel cancer screening 0.6 0.7 1.4 -0.5 -0.6 0.9 -0.8 -1.2
Diabetes diagnosed by doctor 0.7 1.2 2.8 -0.2 -0.9 0.5 -1.7 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.6 0.3 0.9 -1.2 -0.5 -0.2
Friendships satisfaction 1.5 1.8 3.3 -1.2 1.5 -1.8 0.6 1.2
Qualifications: nursing, teaching 0.1 0.1 0.5 0.4 -0.1 -0.0 -0.7 -0.2
Commuting to job workplace: Walk 0.4 0.4 0.8 -0.2 0.9 -0.4 -0.8 -0.5
Eye problems/disorders: Cataract 1.1 1.2 4.6 -0.4 -0.3 0.6 -2.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 7.6 12.1 48.7 7.0 -1.8 -2.0 1.2 1.8
Medication for cholesterol 1.8 2.7 4.5 1.8 1.6 -1.1 2.1 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 3.5 -1.4 0.9 1.9 -1.1 -0.6
Back pain experienced in last month 0.7 1.0 3.1 0.0 0.8 -1.0 0.7 1.8
Mineral and other dietary supplements 1.6 2.1 7.3 -0.3 -1.4 0.6 -0.9 -2.7
Breast cancer (self-reported) 1.0 1.2 3.1 -0.3 -1.8 1.4 0.7 0.4
Asthma (self-reported) 1.4 2.7 8.2 -1.1 1.1 -2.9 0.0 1.7
Osteoporosis (self-reported) 0.7 0.9 2.0 -1.0 -0.0 -1.4 1.0 0.6
Osteoarthritis (self-reported) 1.0 1.2 2.0 -1.4 0.3 0.6 -1.4 1.4
Medication: Aspirin 3.9 5.1 9.6 0.1 -2.9 3.1 -0.8 -2.6
Medication: Gliclazide 0.4 0.5 1.5 -0.1 -0.2 0.4 -0.9 -1.2
Illnesses of father: None of the above (group 1) 3.5 4.3 7.2 2.2 1.4 -2.7 1.3 2.4
Smoking status: Current 0.3 0.5 1.6 -1.3 0.0 0.5 0.3 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.0 0.1 0.2 0.6 -1.0 0.1
Whole body water mass 1.6 9.2 19.0 0.8 3.7 -3.0 2.0 4.4
Leg predicted mass (right) 1.1 5.6 13.3 0.3 2.8 -1.6 2.0 3.6
Arm fat mass (left) 0.4 1.4 3.0 -0.9 1.6 0.3 0.9 1.7
Number of self-reported non-cancer illnesses 0.5 0.8 2.0 -1.0 -0.2 -1.4 -0.2 -1.0
Average weekly champagne plus white wine intake 3.2 4.4 16.0 -0.5 4.0 -1.4 0.1 1.9
Miserableness 0.5 0.8 1.4 -0.5 0.8 -1.2 0.8 1.0
Guilty feelings 0.2 0.2 0.9 -0.1 -0.2 -0.0 -1.0 0.4
Wears glasses or contact lenses 1.6 1.9 4.2 1.6 1.5 -2.1 -0.5 0.1
Ever taken oral contraceptive pill 0.5 0.5 1.2 0.3 -0.1 0.9 -0.8 -1.1
Hearing aid user 0.7 0.8 2.2 1.3 -0.2 -0.0 0.1 1.5
Mother’s age at death 0.5 0.7 1.6 0.4 -0.2 1.0 -0.8 -1.3
Financial situation satisfaction 1.0 1.2 3.4 -1.8 0.6 -0.5 1.1 0.9
Tinnitus: Yes, now most or all of the time 2.1 2.4 7.5 0.4 -2.7 0.3 -1.2 -1.7
Commuting to job workplace: Public transport 1.7 2.0 4.9 1.4 1.6 -2.2 0.6 0.5
Eye problems/disorders: Glaucoma 1.0 1.1 3.6 -1.1 0.8 0.5 0.0 -1.9
Medication: Blood pressure 1.8 3.5 6.3 -1.3 -1.4 2.2 -1.6 -2.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.9 0.0 -0.9 -1.4 -0.6 1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.1 0.4 1.0 -0.6 -0.0 1.4
High cholesterol (Self-reported) 0.4 0.7 1.4 1.2 -0.8 0.6 0.4 -0.9
Medication: Bendroflumethiazide 2.7 4.1 6.0 -2.4 0.9 2.2 -2.0 -2.3
Medication: Paracetamol 0.2 0.3 0.8 0.6 -0.2 -0.9 0.5 0.6
Medication: Lisinopril 1.0 1.3 3.6 -0.4 -0.9 0.8 -1.2 -1.9
Medication: Atorvastatin 0.4 0.5 1.1 -0.6 -0.5 0.7 -0.4 -1.1
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.2 -0.1 -0.5 -0.1 0.4
Alcohol drinker status: Never 0.9 1.1 2.7 -0.1 1.3 1.6 0.9 0.6
Ever smoked 0.2 0.4 0.9 0.4 1.0 -0.7 0.5 0.2
Basal metabolic rate 1.6 8.9 19.0 0.4 3.7 -2.8 2.1 4.4
Leg fat percentage (left) 0.3 1.0 2.6 -1.6 0.7 1.0 -0.7 0.6
Arm fat-free mass (left) 1.7 8.5 20.1 0.2 3.4 -2.9 1.4 4.5
Number of operations (self-reported) 1.6 2.3 6.5 1.1 1.7 -2.6 0.7 0.8
Average weekly beer plus cider intake 1.5 2.2 4.9 1.3 -2.2 -1.6 1.0 0.6
Irritability 0.4 0.6 1.2 -0.6 1.1 -0.8 0.2 1.0
Risk taking 1.0 1.5 5.3 -0.4 -1.0 0.5 -2.3 0.9
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.7 1.5 1.6 -0.9 1.9 0.4
Fractured/broken bones in last 5 years 1.1 1.4 3.4 -0.2 0.5 -1.6 -0.9 1.8
Age started oral contraceptive pill 1.4 1.8 6.5 0.9 0.4 2.5 1.2 0.2
Diastolic blood pressure, automated reading 1.9 5.8 9.2 -0.7 3.0 -2.6 2.4 2.6
Ever depressed for a whole week 0.4 0.5 1.3 -1.1 -0.8 0.1 -0.6 -0.4
Unable to work because of sickness or disability 0.8 1.1 3.2 -1.2 -0.6 1.8 -0.2 0.4
Commuting to job workplace: Cycle 0.3 0.3 1.0 -0.4 -0.5 -0.3 -0.1 -1.0
Myopia 1.0 1.5 3.3 1.7 -1.0 0.3 0.3 -1.8
Vascular/heart problems diagnosed by doctor 0.4 1.1 1.5 1.1 1.2 -1.1 0.6 1.1
Cholesterol lowering medication 0.6 0.9 1.8 0.7 -1.3 0.7 -0.5 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.5 -0.1 0.3 0.1 0.5 0.7
Pain experienced in last month 0.8 1.4 3.8 0.8 1.9 -0.4 1.3 -0.9
Supplements: Calcium 0.5 0.5 1.2 -0.9 -0.4 -0.6 0.1 1.1
Basal cell carcinoma (self-reported) 1.1 1.3 2.4 1.5 -0.8 1.5 1.2 -0.3
Heart attack/myocardial infarction (self-reported) 3.3 4.2 7.9 -2.6 -2.8 1.7 -1.7 -0.7
Deep venous thrombosis (DVT) (self-reported) 4.9 6.4 10.2 -1.1 -3.0 2.5 -2.2 -3.2
Heart disease (siblings) 2.0 2.5 6.0 -2.4 -0.8 1.5 -1.5 -1.1
Alcohol drinker status: Previous 1.8 2.0 4.9 -2.2 0.6 0.8 -1.6 -1.2
Pack years of smoking 0.6 0.9 3.5 -0.1 -0.7 0.1 0.5 1.9
Impedance of whole body 0.4 2.1 7.4 -0.8 -1.2 -0.9 0.2 -2.7
Leg fat mass (left) 0.5 1.9 4.0 -1.5 1.7 -0.1 0.4 2.0
Arm predicted mass (left) 2.0 10.1 22.8 0.5 3.9 -3.1 1.5 4.8