Hub : Genes

TMIE

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0930	0.0410	0.00850	0.009	NA	0.007	NA	0.012	0.08200	NA	9.6e-02	NA	0.0530
2	METSIM	Adipose	0.0500	0.0230	0.00610	0.009	0.008	0.024	0.014	0.015	0.01400	1.7e-02	1.2e-04	3.1e-03	0.0021
3	ROSMAP	Brain Pre-frontal Cortex	0.0924	0.0360	0.00036	0.022	0.050	0.041	0.052	0.029	0.00066	4.9e-07	5.1e-06	2.9e-07	0.0001
4	TCGA	Breast Invasive Carcinoma	0.0291	0.0181	0.00140	0.007	0.010	0.010	NA	0.008	0.01400	3.2e-03	3.4e-03	NA	0.0069
5	TCGA	Thyroid Carcinoma	0.0520	0.0230	0.00020	0.014	0.030	0.035	NA	0.020	0.01300	5.6e-04	2.2e-04	NA	0.0047

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	1.0	3.4	-0.2	0.7	1.9	0.3	0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	3.0	0.7	1.5	-0.1	1.2	1.7
Depressed Affect (Nagel 2018)	0.7	1.5	3.8	-1.2	2.0	0.2	-0.4	1.3
Depression (Nagel 2018)	1.2	1.8	3.7	-0.3	1.6	-1.5	0.4	1.9
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.6	0.2	-0.5	0.4	0.1
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.0	1.0	-0.2	-1.0	0.6
Schizophrenia (2018)	0.9	1.9	2.7	1.1	1.3	-1.6	1.1	1.6
Schizophrenia vs Biploar Disorder	1.1	1.5	6.9	-0.2	0.5	-2.6	0.4	-0.5
Worry (Nagel 2018)	0.1	0.3	1.0	1.0	0.1	0.5	-0.2	-0.4
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	-0.6	0.3	-0.7	0.9	0.7
Alzheimer’s Disease (in father)	0.8	0.8	3.8	0.3	0.1	0.2	2.0	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	-0.4	-0.0	-0.3	0.8	-0.0
Crohns Disease (2017)	0.6	1.4	3.7	1.9	0.0	1.7	-0.5	0.4
Irritable Bowel Disease (IBD)	1.3	3.0	10.4	0.8	-1.1	3.2	-1.6	-0.3
Ulcerative Colitis (UC)	2.2	4.1	12.3	-0.6	-1.6	3.5	-2.1	-0.8
Major Depression (MDD)	2.2	2.7	5.1	0.3	2.2	-2.2	-1.7	0.6
Reaction Time	0.8	1.6	7.4	0.2	-2.7	-0.5	0.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.9	-0.5	1.7	-1.0	1.6	0.0
Breast Cancer	1.8	4.3	9.3	-1.0	1.0	-3.0	2.8	1.6
Ovarian Cancer	0.8	1.0	2.0	-1.3	0.8	-1.4	-0.8	0.0
Prostate Cancer	0.5	0.7	1.8	0.4	-0.8	-0.8	-1.3	-0.4
Age at First Birth	0.7	1.0	3.8	-0.1	1.0	-0.6	1.9	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.1	-0.3	1.5	0.9	-0.8	1.4
Coronary Artery Disease (CAD)	1.3	1.6	4.4	-2.1	0.4	0.5	-1.6	-0.8
Crohns Disease (2012)	0.5	0.7	1.9	1.2	-0.2	1.4	0.3	-0.3
Mean Putamen Volume	2.1	2.4	6.9	0.2	0.1	-0.8	2.1	2.6
Fasting Glucose	0.4	0.4	1.5	0.4	1.2	0.5	0.2	-0.4
HbA1C	0.3	0.3	0.7	0.8	-0.4	-0.4	-0.9	-0.2
HDL Cholesterol	0.5	0.9	2.0	0.8	-0.1	1.3	1.4	0.4
LDL Cholesterol	0.4	0.6	2.3	0.7	-1.5	-0.7	0.1	0.2
Lupus	2.1	3.2	7.6	-1.2	1.0	-1.5	1.9	2.8
Neuroticism (2016)	0.3	0.4	0.7	-0.4	0.6	-0.9	-0.6	0.7
Primary Biliary Cirrhosis	0.2	0.3	1.1	0.1	-0.5	-1.1	0.1	-0.1
Rheumatoid Arthritis	1.3	1.8	4.8	2.2	-0.8	-0.1	-1.1	-1.6
Schizophrenia (2014)	0.4	0.9	2.0	-0.5	1.4	-1.1	0.8	0.8
Triglycerides	1.3	2.1	5.5	-0.5	1.5	-2.3	-0.1	1.6
Type 2 Diabetes (T2D) (2012)	4.4	5.1	8.6	-2.5	-1.2	1.6	-2.9	-2.6
Ulcerative Colitis	1.4	2.1	4.9	-1.4	-0.8	2.2	-1.5	-0.8
Blood Eosinophil Count	0.6	4.6	14.7	3.8	-1.2	-1.4	-2.1	0.7
Blood Platelet Count	0.3	3.6	8.3	-0.5	0.2	2.9	-2.8	-1.4
Blood Red Count	0.3	2.5	6.4	-0.1	2.5	-1.5	1.8	0.9
Blood White Count	2.1	15.7	40.1	-2.5	-3.7	2.5	-6.3	-3.5
Heel T-Score	0.6	4.4	10.3	-0.6	-1.8	0.6	-3.2	-2.8
BMI	0.5	2.8	5.8	-1.4	2.3	1.1	0.1	2.4
Height	2.0	38.5	80.1	2.0	5.1	-8.9	6.9	5.9
Waist Hip Ratio (WHR)	2.0	9.1	16.4	-3.0	-3.2	1.6	-4.0	-2.6
Systolic Blood Pressure	0.3	1.3	2.7	-1.5	1.6	-1.0	-0.3	0.7
Smoking Status	0.2	0.4	1.5	1.2	-0.5	-0.4	0.5	0.2
Allergy or Eczema	0.6	1.6	4.4	0.9	2.1	-1.1	-1.0	0.8
Cardiovascular Disease	0.8	2.6	4.9	-1.7	-0.6	0.9	-2.2	-2.0
Hypothyroidism (self reported)	0.6	1.3	2.1	-1.4	0.9	-0.0	-1.4	-1.3
Respiratory disease	0.6	1.3	2.8	-1.1	0.1	-1.7	-0.9	1.4
Type 2 Diabetes (T2D) (2018)	1.9	3.5	8.1	-0.3	-1.0	0.9	-2.9	-2.7
Lung FEV1/FVC ratio	1.0	5.3	13.0	-0.3	1.1	-3.6	2.9	1.9
Lung FVC	0.2	0.9	3.2	0.7	-0.6	1.8	-0.7	-0.3
Neuroticism	0.3	0.6	1.2	0.2	-0.6	0.7	-1.1	-1.0
Chronotype (morning person)	0.6	1.4	2.7	-1.4	-0.8	1.1	-0.9	-1.6
Hair Pigment	0.1	3.7	9.9	3.1	0.3	-1.1	2.4	1.4
Tanning	0.0	0.3	1.0	1.0	-0.4	0.1	0.1	-0.4
Hand grip strength (left)	1.5	3.9	8.7	-0.4	2.3	-1.8	1.4	3.0
Number of treatments/medications taken	0.5	0.8	2.9	-1.7	0.6	0.7	0.4	0.5
Average weekly spirits intake	2.7	3.4	7.7	-2.1	0.8	0.2	2.8	2.0
Sensitivity / hurt feelings	1.1	1.9	6.4	0.4	-1.3	0.8	-2.5	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	-0.9	-0.2	-0.3	0.2	1.2
Hearing difficulty/problems: Yes	0.5	0.7	1.0	0.6	-1.0	0.9	-1.0	-0.5
Relative age of first facial hair	0.1	0.3	1.1	-0.0	-1.1	0.3	-0.0	-0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	0.2	-0.6	0.5	0.1	-0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.2	0.7	-1.8	-0.0	-1.2	-1.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	0.2	-1.5	0.0	-0.8	-0.8
Systolic blood pressure, automated reading	1.2	3.5	7.8	-0.5	2.0	-1.0	2.1	2.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.7	-1.6	-1.3	0.0	-1.3	-1.3
Angina	3.4	4.5	9.7	-2.3	-2.4	3.1	-0.5	-1.1
Medication for hormone replacement therapy	0.9	1.0	2.4	-0.7	0.3	-0.7	-1.6	1.2
Vitamin and mineral supplements	1.1	1.5	3.6	-1.1	-0.7	0.5	-1.4	-1.9
Supplements: Zinc	0.2	0.2	0.4	0.6	0.1	-0.5	-0.5	-0.4
Medication: Co-codamol	0.6	0.8	1.5	-0.5	-1.2	0.6	-0.8	-1.0
Medication: Metformin	1.1	1.5	1.9	-0.9	-1.1	1.4	-1.3	-1.4
Diabetes (father)	0.8	1.0	2.7	0.0	-1.3	-0.2	-1.6	-0.7
Diabetes (mother)	1.0	1.2	3.7	-1.9	0.2	-1.5	0.2	0.5
Severe depression (siblings)	0.1	0.2	0.3	0.5	-0.5	-0.0	-0.5	0.2
Pack years adult smoking proportion	0.6	1.0	3.8	-0.3	-0.7	0.3	0.6	2.0
Impedance of leg (right)	0.5	2.3	5.7	-0.8	-0.2	-2.4	-0.6	-2.2
Leg fat-free mass (left)	0.9	4.9	10.5	0.3	2.7	-1.7	2.0	3.2
Trunk fat percentage	0.1	0.5	1.3	-1.2	0.5	0.6	0.9	0.1
Hand grip strength (right)	1.8	4.9	7.3	-1.4	2.7	-2.0	2.0	2.7
Townsend deprivation index at recruitment	0.6	0.8	1.6	-1.0	-1.3	0.6	-0.8	-0.7
Current tobacco smoking	0.4	0.7	2.7	-1.6	0.2	0.8	0.0	0.4
Average weekly fortified wine intake	1.4	1.6	3.2	0.8	1.8	1.6	1.1	0.7
Maternal smoking around birth	2.8	4.1	11.9	1.5	1.9	-3.5	-0.3	1.6
Fed-up feelings	0.4	0.8	1.8	-1.3	0.3	0.4	0.4	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.0	-1.7	0.7	-0.7	-0.1	0.7
Relative age voice broke	1.1	1.7	3.9	0.1	-2.0	1.9	-0.5	-0.8
Taking other prescription medications	1.0	1.6	6.0	-2.5	-0.6	0.7	-0.8	-0.5
Age when periods started (menarche)	0.2	0.6	1.2	0.9	-0.0	-1.1	0.8	-0.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	5.6	-0.8	-0.1	-0.2	-1.4	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.7	0.2	-1.1	-1.4	-1.6	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.5	0.2	1.2	0.3	0.7	0.9
Qualifications: CSEs or equivalent	0.9	1.1	3.8	0.2	-0.2	-1.9	-0.9	1.0
Serious illness, injury or assault to yourself	1.2	1.4	3.2	-0.9	-1.8	0.9	-1.5	0.0
High blood pressure	0.3	0.8	1.5	-0.7	-1.1	0.9	-0.4	-1.2
Hayfever, allergic rhinitis or eczema	1.2	2.6	6.7	0.2	2.6	-2.0	-0.4	1.4
Multivitamins +/- minerals	2.2	2.9	5.0	1.6	1.2	-1.2	1.9	2.2
Stomach or abdominal pain in last month	0.6	0.8	2.8	-0.7	-1.7	0.7	-0.0	0.3
Supplements: Glucosamine	1.2	1.6	3.1	0.4	1.8	-0.9	1.2	1.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	1.2	-0.4	-0.4	-0.3	-0.4
Medication: Atenolol	2.6	3.2	7.3	-1.3	-1.2	2.7	-0.9	-2.2
Medication: Levothyroxine sodium	0.7	1.1	2.5	-1.2	0.4	-1.1	-1.6	-0.4
Sitting height	1.1	8.1	12.6	2.6	3.6	-2.0	3.4	2.3
Chronic bronchitis/emphysema (father)	0.6	0.7	2.6	-1.6	0.9	0.4	-0.2	0.3
High blood pressure (mother)	0.7	1.0	2.5	0.2	1.6	0.2	-0.2	-1.5
Body mass index (BMI)	0.3	1.3	2.9	-1.0	1.0	1.4	0.1	1.7
Impedance of leg (left)	0.4	1.9	5.3	-1.2	-0.2	-2.3	-0.7	-1.5
Leg predicted mass (left)	0.9	4.8	10.2	0.4	2.6	-1.6	2.0	3.2
Trunk fat mass	0.3	1.3	2.2	-0.9	1.5	-0.3	1.3	1.4
Waist circumference	0.2	0.8	1.9	-1.4	0.4	1.0	-1.0	0.3
Number of incorrect matches in round	0.4	0.7	1.3	0.7	-0.5	1.1	0.9	-0.7
Past tobacco smoking	0.4	0.8	1.7	-1.2	-0.4	1.3	-0.5	-0.6
Alcohol usually taken with meals	0.8	1.3	1.9	1.3	1.3	-1.4	-0.9	-0.7
Nervous feelings	0.4	0.7	1.2	0.7	-1.1	0.7	0.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	-1.2	-1.5	0.5	0.5	0.6
Hearing difficulty/problems with background noise	0.7	1.1	2.1	-0.6	-0.5	1.5	-0.9	-1.3
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	-1.5	0.1	0.2	-0.1	-1.2
Had menopause	0.8	1.0	1.3	1.0	-1.1	1.1	0.7	0.9
Had other major operations	0.7	0.9	1.4	-0.6	1.1	-0.8	0.7	1.2
Forced vital capacity (FVC)	0.2	0.9	1.6	1.1	1.2	-1.3	-0.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.6	0.4	-1.5	-1.7	-2.2	-1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	-1.1	0.5	-0.1	-0.4	-0.4
Qualifications: None of the above	0.2	0.5	1.6	0.2	-1.2	0.4	0.9	0.0
Financial difficulties in last 2 years	0.7	0.9	2.4	0.3	0.2	-1.5	-0.5	1.3
Mouth/teeth dental problems	3.0	4.6	14.4	-3.8	2.3	-0.1	-1.3	-1.3
Heart attack	3.6	4.7	9.7	-2.6	-3.1	1.7	-1.8	-0.8
Allergy	1.0	2.4	5.0	0.9	-1.9	2.2	0.5	-1.5
Pain all over the body in last month	2.4	2.5	4.9	-1.2	-2.1	0.8	-2.2	-1.2
Diabetes (self-reported)	0.7	1.0	2.3	-0.3	-0.8	0.2	-1.5	-1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-1.0	0.9	-0.0	-0.4	0.7
Medication: Ramipril	2.5	3.2	6.0	-0.8	-2.4	2.5	-1.5	-1.0
Medication: Simvastatin	0.4	0.6	2.1	0.4	-0.8	1.5	0.2	-0.5
Fluid intelligence score	0.4	0.9	1.8	0.7	1.4	-0.8	1.2	-0.6
Illnesses of siblings	0.1	0.2	0.3	0.5	-0.5	0.4	0.1	-0.3
Neuroticism score	0.1	0.1	0.4	-0.0	-0.3	-0.1	-0.7	-0.2
Weight	1.0	5.0	10.8	-0.5	3.0	-1.5	1.7	3.3
Impedance of arm (right)	0.5	2.5	9.5	-0.5	-1.4	-0.4	0.7	-3.1
Arm fat percentage (right)	0.2	0.8	2.2	-1.2	0.6	1.5	0.3	0.2
Trunk fat-free mass	1.9	11.0	22.5	0.9	4.0	-3.4	2.0	4.7
Hip circumference	0.8	3.6	9.4	-0.5	3.1	-0.8	1.7	2.2
Time employed in main current job	0.5	0.5	1.9	0.8	-0.1	-0.3	1.4	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	1.8	0.1	0.1	-1.3	-0.4	0.4
Father’s age at death	0.6	0.8	2.5	1.6	0.2	-0.8	-0.4	-0.7
Worrier / anxious feelings	0.4	0.7	1.4	1.0	-0.8	-0.4	-1.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.1	-0.4	-0.5	0.0	0.9
Falls in the last year	1.6	2.2	6.2	-1.8	0.7	-0.9	0.2	2.5
Hair/balding pattern: Pattern 3	0.7	1.0	3.1	-1.0	-1.8	0.2	-1.0	0.2
Number of live births	0.4	0.5	1.9	-0.0	-0.7	1.4	0.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.9	0.8	1.1	-1.7	-0.0	0.3
Pulse rate	0.2	0.4	0.9	-0.0	1.0	-0.8	0.1	-0.4
Happiness	1.5	1.9	4.1	-1.6	0.3	-2.0	1.3	0.8
Noisy workplace	0.8	0.9	3.1	-1.8	0.0	-0.6	0.4	1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.6	1.2	0.0	-1.6	-0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.1	-0.6	-0.0	0.3	-1.4	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	-0.1	-0.7	0.1	0.9	1.1
Asthma	1.3	2.6	8.2	-0.9	1.0	-2.9	-0.4	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	-1.1	-0.4	-0.1	-0.1	0.2
Medication: Cholesterol lowering	0.4	0.6	1.9	-0.8	-0.1	1.4	0.4	0.4
Depression (self-reported)	1.1	1.3	3.7	0.7	-0.4	0.5	1.4	1.9
Medication: Lansoprazole	1.7	2.0	6.6	-0.6	-1.1	0.9	-2.6	-0.9
Prospective memory result	0.5	0.6	0.9	-0.8	-0.9	-0.0	1.0	0.9
Lung cancer (father)	1.6	1.9	4.7	2.2	-1.3	1.4	1.1	0.4
Illnesses of mother	1.0	1.2	3.5	0.3	-0.3	-1.2	0.9	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.7	0.8	-1.0	0.0	0.4
Pulse wave Arterial Stiffness index	0.9	1.1	3.0	-0.9	-0.0	-1.7	0.9	0.9
Impedance of arm (left)	0.6	2.9	11.7	-0.4	-1.4	0.0	0.9	-3.4
Arm fat mass (right)	0.4	1.6	3.5	-1.0	1.7	0.2	0.9	1.9
Trunk predicted mass	1.9	11.0	22.3	0.9	4.0	-3.5	2.0	4.7
Standing height	1.9	19.2	39.3	1.0	4.8	-6.3	4.1	4.0
Length of working week for main job	0.6	0.7	2.2	-1.5	0.1	0.8	0.3	0.5
Exposure to tobacco smoke at home	1.4	1.6	2.8	-1.6	0.0	-1.4	0.7	1.7
Breastfed as a baby	0.6	0.8	2.0	0.3	1.0	-0.3	1.4	0.8
Tense / ‘highly strung’	0.1	0.2	0.6	0.7	0.0	-0.6	0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	0.0	0.2	0.0	-0.9	-1.2
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	0.9	-0.1	1.3	0.1	-0.5
Birth weight of first child	1.8	3.3	6.4	0.7	2.1	-1.7	1.4	2.5
Peak expiratory flow (PEF)	0.7	1.7	6.1	2.5	0.1	-1.4	-0.7	0.5
Pulse wave reflection index	0.4	0.4	1.2	-1.1	-0.3	-0.3	0.2	0.9
Ever highly irritable/argumentative for 2 days	1.4	1.7	7.2	-2.7	-0.2	1.1	-0.2	0.2
Loud music exposure frequency	0.6	0.7	1.5	-1.2	-0.5	-0.5	-0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.2	0.6	0.5	-1.8	-0.5	1.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.6	1.4	-1.6	1.1	-0.1	0.2
Blood clot in the leg (DVT)	5.4	7.0	12.5	-1.0	-3.0	2.6	-2.5	-3.5
Medication: Paracetamol	0.8	1.3	2.7	0.8	0.1	-1.7	1.2	1.4
Headache pain in last month	0.3	0.6	2.1	0.5	-1.4	-0.2	-0.7	0.4
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	9.2	1.4	0.4	-3.0	-0.1	0.5
Glaucoma (self-reported)	1.2	1.4	4.8	-0.8	-0.7	0.9	-0.1	-2.2
Gout (self-reported)	0.4	0.6	1.0	-1.0	0.9	0.0	0.5	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.9	-0.5	0.3	-0.5	-1.7	-0.9
Medication: Amlodipine	1.8	2.5	10.2	-3.2	1.4	-0.0	0.3	-0.3
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.0	-1.7	1.5	-1.7	0.2	1.0
Birth weight	1.2	2.5	5.5	0.6	1.2	-1.6	1.7	2.4
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.9	0.5	-1.4	-0.5	-0.6	1.0
High blood pressure (siblings)	0.5	0.8	1.6	-0.2	1.3	-0.4	1.3	0.7
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	0.7	1.1	-0.7	-0.3	0.6
Body fat percentage	0.2	0.6	1.7	-1.3	0.6	0.9	0.3	0.1
Leg fat percentage (right)	0.2	0.7	1.6	-1.3	0.7	0.8	-0.7	0.1
Arm fat-free mass (right)	1.8	9.3	19.6	0.3	3.8	-3.1	1.7	4.4
Exposure to tobacco smoke outside home	1.6	2.1	6.0	-0.8	0.5	-1.8	0.6	2.5
Comparative body size at age 10	1.1	3.0	7.1	-0.5	2.0	-0.2	1.8	2.7
Number of full brothers	0.7	0.8	1.5	1.1	0.6	-0.3	1.0	1.2
Worry too long after embarrassment	0.6	1.0	4.3	-0.5	-0.5	-0.1	-2.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.3	0.7	0.3	-0.7	-0.1
Wheeze or whistling in the chest in last year	1.6	2.8	11.4	-3.4	-0.5	0.4	-0.1	1.5
Number of children fathered	2.6	2.9	9.4	0.1	1.1	-0.9	3.1	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	-0.1	-0.7	0.9	0.3	0.4
Age at first live birth	2.0	3.6	8.7	0.9	2.5	-3.0	1.4	-0.2
Pulse wave peak to peak time	0.5	0.6	1.1	0.9	0.4	1.0	-0.7	-0.6
Health satisfaction	1.5	2.0	6.9	-2.6	0.6	-0.4	0.4	1.6
Shortness of breath walking on level ground	0.7	0.8	1.3	-1.1	-1.0	-0.5	-0.6	1.0
Qualifications: College or University degree	0.8	2.5	6.1	1.3	-0.1	-0.6	-2.1	-2.5
Eye problems/disorders: None of the above	1.5	1.8	5.4	2.3	0.3	-0.9	1.5	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.7	-0.1	1.1	-0.2	1.3	1.2
Emphysema/chronic bronchitis	1.1	1.3	3.8	-0.4	0.2	-1.1	1.0	2.0
Medication for pain relief, constipation, heartburn	0.5	0.8	1.7	0.6	1.3	-1.2	-0.7	0.0
Neck or shoulder pain in last month	0.4	0.6	1.4	-0.1	-1.2	1.1	0.0	0.6
Medication: Blood pressure	1.4	2.5	4.2	-1.9	-0.3	2.1	-1.1	-1.9
Angina (self-reported)	3.4	4.5	9.8	-2.3	-2.4	3.1	-0.7	-1.2
Migraine (self-reported)	0.3	0.4	0.8	0.9	-0.2	-0.0	-0.8	-0.6
Medication: Ibuprofen	0.2	0.3	1.0	-1.0	0.1	-0.1	0.5	0.4
Medication: Allopurinol	2.3	3.0	4.6	-0.7	1.8	-1.9	2.1	1.7
Medication: Omeprazole	0.4	0.5	1.5	-0.6	0.4	-0.5	0.4	1.2
Medication: Seretide 50 evohaler	2.4	2.8	4.9	-1.6	0.9	-1.1	2.1	2.2
Mean time to correctly identify matches	1.1	2.1	9.4	0.4	-3.1	-0.4	0.7	-0.6
Heart disease (mother)	1.4	1.7	2.9	0.6	-1.7	1.3	-1.2	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.2	-0.1	1.5	0.2	-1.0	-0.8
Whole body fat mass	0.4	1.5	2.5	-1.1	1.6	-0.3	1.1	1.6
Leg fat mass (right)	0.4	1.4	3.0	-1.2	1.6	0.0	0.3	1.7
Arm predicted mass (right)	1.6	8.3	17.6	0.6	3.5	-2.9	1.9	4.2
Pulse rate, automated reading	0.2	0.8	2.2	0.6	-0.3	0.1	-1.1	-1.5
Alcohol intake frequency.	0.5	1.3	2.3	-1.3	0.3	1.5	-1.0	-1.2
Comparative height size at age 10	2.2	11.9	25.4	-1.9	3.3	-5.0	2.4	3.7
Number of full sisters	0.9	1.1	3.2	0.6	-1.2	-0.3	0.4	1.8
Suffer from ‘nerves’	0.8	1.2	4.6	2.1	-1.1	-0.1	-0.4	-0.4
Overall health rating	1.1	2.4	5.7	-1.9	-2.4	1.5	-0.8	0.2
Chest pain or discomfort	0.5	0.8	2.7	0.6	-1.6	0.4	-0.6	-0.4
Had major operations	0.6	0.7	2.7	0.4	-0.3	-1.7	0.5	0.6
Age at last live birth	1.7	2.4	4.0	1.4	2.0	-1.7	1.7	-0.0
Family relationship satisfaction	2.6	3.1	5.6	-1.8	1.5	-2.0	0.8	2.4
Leg pain on walking	2.4	3.0	6.6	-1.3	1.4	-2.6	0.1	2.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	-0.7	1.7	-0.8	0.8	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.7	0.3	0.3	0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.1	-0.3	1.3	-0.0	1.8	0.1
Medication: Aspirin	2.4	3.2	6.7	0.1	-2.3	2.6	0.0	-2.0
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	0.1	0.3	-0.1	-0.1
Knee pain experienced in last month	0.4	0.7	1.9	-0.6	-0.4	0.3	-1.4	1.0
Hypertension (Self-reported)	0.7	1.9	3.0	-0.9	-1.6	1.4	-0.9	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.7	-0.1	-0.7	1.1	0.9
Illnesses of father: Heart disease	3.6	5.0	7.2	-2.6	-1.1	1.8	-2.5	-2.7
Illnesses of siblings: Diabetes	0.3	0.4	1.4	-0.3	-1.2	0.4	0.2	-0.4
Smoking status: Previous	0.7	1.0	3.2	1.8	0.1	-1.2	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	11.4	-1.7	2.3	-2.6	3.0	3.4
Whole body fat-free mass	1.5	8.8	18.9	0.7	3.5	-2.9	2.0	4.3
Leg fat-free mass (right)	1.0	5.5	12.8	0.4	2.8	-1.6	2.0	3.6
Arm fat percentage (left)	0.3	1.0	3.2	-1.2	0.5	1.8	0.4	0.1
Average weekly red wine intake	0.5	0.7	1.6	1.3	0.2	-0.7	-0.5	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	-0.7	1.4	0.2	-0.7	0.7
Mood swings	0.0	0.0	0.1	-0.3	0.0	0.3	-0.0	0.2
Loneliness, isolation	0.7	1.0	3.5	-1.0	0.3	0.1	-1.9	-0.7
Long-standing illness, disability or infirmity	0.4	0.7	1.6	-1.3	-0.6	0.2	-1.1	-0.2
Ever had bowel cancer screening	0.6	0.7	1.4	-0.5	-0.6	0.9	-0.8	-1.2
Diabetes diagnosed by doctor	0.7	1.2	2.8	-0.2	-0.9	0.5	-1.7	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.6	0.3	0.9	-1.2	-0.5	-0.2
Friendships satisfaction	1.5	1.8	3.3	-1.2	1.5	-1.8	0.6	1.2
Qualifications: nursing, teaching	0.1	0.1	0.5	0.4	-0.1	-0.0	-0.7	-0.2
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.2	0.9	-0.4	-0.8	-0.5
Eye problems/disorders: Cataract	1.1	1.2	4.6	-0.4	-0.3	0.6	-2.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	7.6	12.1	48.7	7.0	-1.8	-2.0	1.2	1.8
Medication for cholesterol	1.8	2.7	4.5	1.8	1.6	-1.1	2.1	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	3.5	-1.4	0.9	1.9	-1.1	-0.6
Back pain experienced in last month	0.7	1.0	3.1	0.0	0.8	-1.0	0.7	1.8
Mineral and other dietary supplements	1.6	2.1	7.3	-0.3	-1.4	0.6	-0.9	-2.7
Breast cancer (self-reported)	1.0	1.2	3.1	-0.3	-1.8	1.4	0.7	0.4
Asthma (self-reported)	1.4	2.7	8.2	-1.1	1.1	-2.9	0.0	1.7
Osteoporosis (self-reported)	0.7	0.9	2.0	-1.0	-0.0	-1.4	1.0	0.6
Osteoarthritis (self-reported)	1.0	1.2	2.0	-1.4	0.3	0.6	-1.4	1.4
Medication: Aspirin	3.9	5.1	9.6	0.1	-2.9	3.1	-0.8	-2.6
Medication: Gliclazide	0.4	0.5	1.5	-0.1	-0.2	0.4	-0.9	-1.2
Illnesses of father: None of the above (group 1)	3.5	4.3	7.2	2.2	1.4	-2.7	1.3	2.4
Smoking status: Current	0.3	0.5	1.6	-1.3	0.0	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.0	0.1	0.2	0.6	-1.0	0.1
Whole body water mass	1.6	9.2	19.0	0.8	3.7	-3.0	2.0	4.4
Leg predicted mass (right)	1.1	5.6	13.3	0.3	2.8	-1.6	2.0	3.6
Arm fat mass (left)	0.4	1.4	3.0	-0.9	1.6	0.3	0.9	1.7
Number of self-reported non-cancer illnesses	0.5	0.8	2.0	-1.0	-0.2	-1.4	-0.2	-1.0
Average weekly champagne plus white wine intake	3.2	4.4	16.0	-0.5	4.0	-1.4	0.1	1.9
Miserableness	0.5	0.8	1.4	-0.5	0.8	-1.2	0.8	1.0
Guilty feelings	0.2	0.2	0.9	-0.1	-0.2	-0.0	-1.0	0.4
Wears glasses or contact lenses	1.6	1.9	4.2	1.6	1.5	-2.1	-0.5	0.1
Ever taken oral contraceptive pill	0.5	0.5	1.2	0.3	-0.1	0.9	-0.8	-1.1
Hearing aid user	0.7	0.8	2.2	1.3	-0.2	-0.0	0.1	1.5
Mother’s age at death	0.5	0.7	1.6	0.4	-0.2	1.0	-0.8	-1.3
Financial situation satisfaction	1.0	1.2	3.4	-1.8	0.6	-0.5	1.1	0.9
Tinnitus: Yes, now most or all of the time	2.1	2.4	7.5	0.4	-2.7	0.3	-1.2	-1.7
Commuting to job workplace: Public transport	1.7	2.0	4.9	1.4	1.6	-2.2	0.6	0.5
Eye problems/disorders: Glaucoma	1.0	1.1	3.6	-1.1	0.8	0.5	0.0	-1.9
Medication: Blood pressure	1.8	3.5	6.3	-1.3	-1.4	2.2	-1.6	-2.5
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.9	0.0	-0.9	-1.4	-0.6	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	0.4	1.0	-0.6	-0.0	1.4
High cholesterol (Self-reported)	0.4	0.7	1.4	1.2	-0.8	0.6	0.4	-0.9
Medication: Bendroflumethiazide	2.7	4.1	6.0	-2.4	0.9	2.2	-2.0	-2.3
Medication: Paracetamol	0.2	0.3	0.8	0.6	-0.2	-0.9	0.5	0.6
Medication: Lisinopril	1.0	1.3	3.6	-0.4	-0.9	0.8	-1.2	-1.9
Medication: Atorvastatin	0.4	0.5	1.1	-0.6	-0.5	0.7	-0.4	-1.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	-0.1	-0.5	-0.1	0.4
Alcohol drinker status: Never	0.9	1.1	2.7	-0.1	1.3	1.6	0.9	0.6
Ever smoked	0.2	0.4	0.9	0.4	1.0	-0.7	0.5	0.2
Basal metabolic rate	1.6	8.9	19.0	0.4	3.7	-2.8	2.1	4.4
Leg fat percentage (left)	0.3	1.0	2.6	-1.6	0.7	1.0	-0.7	0.6
Arm fat-free mass (left)	1.7	8.5	20.1	0.2	3.4	-2.9	1.4	4.5
Number of operations (self-reported)	1.6	2.3	6.5	1.1	1.7	-2.6	0.7	0.8
Average weekly beer plus cider intake	1.5	2.2	4.9	1.3	-2.2	-1.6	1.0	0.6
Irritability	0.4	0.6	1.2	-0.6	1.1	-0.8	0.2	1.0
Risk taking	1.0	1.5	5.3	-0.4	-1.0	0.5	-2.3	0.9
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.7	1.5	1.6	-0.9	1.9	0.4
Fractured/broken bones in last 5 years	1.1	1.4	3.4	-0.2	0.5	-1.6	-0.9	1.8
Age started oral contraceptive pill	1.4	1.8	6.5	0.9	0.4	2.5	1.2	0.2
Diastolic blood pressure, automated reading	1.9	5.8	9.2	-0.7	3.0	-2.6	2.4	2.6
Ever depressed for a whole week	0.4	0.5	1.3	-1.1	-0.8	0.1	-0.6	-0.4
Unable to work because of sickness or disability	0.8	1.1	3.2	-1.2	-0.6	1.8	-0.2	0.4
Commuting to job workplace: Cycle	0.3	0.3	1.0	-0.4	-0.5	-0.3	-0.1	-1.0
Myopia	1.0	1.5	3.3	1.7	-1.0	0.3	0.3	-1.8
Vascular/heart problems diagnosed by doctor	0.4	1.1	1.5	1.1	1.2	-1.1	0.6	1.1
Cholesterol lowering medication	0.6	0.9	1.8	0.7	-1.3	0.7	-0.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.5	-0.1	0.3	0.1	0.5	0.7
Pain experienced in last month	0.8	1.4	3.8	0.8	1.9	-0.4	1.3	-0.9
Supplements: Calcium	0.5	0.5	1.2	-0.9	-0.4	-0.6	0.1	1.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	1.5	-0.8	1.5	1.2	-0.3
Heart attack/myocardial infarction (self-reported)	3.3	4.2	7.9	-2.6	-2.8	1.7	-1.7	-0.7
Deep venous thrombosis (DVT) (self-reported)	4.9	6.4	10.2	-1.1	-3.0	2.5	-2.2	-3.2
Heart disease (siblings)	2.0	2.5	6.0	-2.4	-0.8	1.5	-1.5	-1.1
Alcohol drinker status: Previous	1.8	2.0	4.9	-2.2	0.6	0.8	-1.6	-1.2
Pack years of smoking	0.6	0.9	3.5	-0.1	-0.7	0.1	0.5	1.9
Impedance of whole body	0.4	2.1	7.4	-0.8	-1.2	-0.9	0.2	-2.7
Leg fat mass (left)	0.5	1.9	4.0	-1.5	1.7	-0.1	0.4	2.0
Arm predicted mass (left)	2.0	10.1	22.8	0.5	3.9	-3.1	1.5	4.8