Hub : Genes

LRRC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.4350	0.0500	0.0e+00	0.335	0.299	0.349	0.353	0.361	5.9e-42	9.1e-37	3.9e-44	9.4e-45	7.0e-46
2	GTEx	Adrenal Gland	0.5808	0.0659	2.8e-09	0.395	NA	0.454	NA	0.445	2.5e-15	NA	4.3e-18	NA	1.2e-17
3	GTEx	Artery Aorta	0.0850	0.0400	8.7e-03	0.005	NA	0.002	NA	0.001	1.7e-01	NA	2.5e-01	NA	2.6e-01
4	GTEx	Brain Cerebellum	0.4760	0.1040	1.9e-05	0.262	NA	0.346	NA	0.374	2.3e-08	NA	4.9e-11	NA	5.2e-12
5	GTEx	Brain Cortex	0.3540	0.1010	2.1e-04	0.103	NA	0.149	NA	0.106	8.8e-04	NA	6.6e-05	NA	7.6e-04
6	GTEx	Cells Transformed fibroblasts	0.6270	0.0480	0.0e+00	0.425	NA	0.490	NA	0.482	2.2e-34	NA	1.8e-41	NA	1.6e-40
7	GTEx	Esophagus Muscularis	0.1740	0.0670	8.9e-04	0.005	NA	-0.002	NA	0.004	1.5e-01	NA	4.4e-01	NA	1.6e-01
8	GTEx	Testis	0.3750	0.0800	1.0e-05	0.160	NA	0.200	NA	0.205	1.3e-07	NA	3.0e-09	NA	1.8e-09
9	ROSMAP	Brain Pre-frontal Cortex	0.4593	0.0454	0.0e+00	0.291	0.391	0.410	0.400	0.404	1.0e-37	1.6e-53	8.5e-57	3.6e-55	7.1e-56
10	TCGA	Brain Lower Grade Glioma	0.0385	0.0188	5.3e-03	0.027	0.018	0.019	NA	0.021	3.9e-04	3.6e-03	2.7e-03	NA	1.6e-03
11	TCGA	Prostate Adenocarcinoma	0.0652	0.0324	5.9e-04	0.004	0.019	0.018	NA	0.007	1.1e-01	3.7e-03	4.9e-03	NA	5.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.4	2.3	0.1	-0.4	0.5	-0.3	1.5	-0.1	-0.4	-0.2	-0.7	-0.0	-0.6
Bipolar Disorder or Schizophrenia	1.3	3.3	10.1	2.2	0.5	1.0	-1.8	3.2	0.8	-2.0	1.7	1.9	1.9	-1.3
Depressed Affect (Nagel 2018)	0.5	1.1	3.7	0.8	-0.3	1.9	-1.0	1.9	-0.2	0.8	0.3	1.0	0.3	-0.9
Depression (Nagel 2018)	0.6	0.9	2.4	1.2	-1.5	0.3	-0.7	0.9	-0.2	-0.6	0.4	1.2	1.1	-1.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.5	-0.1	1.9	1.0	-1.2	0.9	1.3	0.1	1.1	-1.1	0.1	1.2
Neuroticism (Nagel 2018)	0.1	0.3	1.2	0.3	-0.3	1.1	-1.1	1.0	-0.0	-0.2	0.2	0.3	0.0	-0.2
Schizophrenia (2018)	2.2	4.6	9.6	2.7	1.0	0.9	-2.0	2.9	1.1	-2.3	2.4	3.1	2.4	-1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	3.3	-0.2	0.8	-0.6	-0.9	-0.9	1.1	0.2	0.3	-0.3	0.1	1.8
Worry (Nagel 2018)	0.1	0.2	0.7	-0.5	-0.1	-0.9	-0.0	-0.5	-0.2	-0.3	-0.4	-0.4	-0.4	0.3
Alzheimer’s Disease (in mother)	0.7	0.8	3.6	-0.7	-0.7	-1.9	-0.2	-0.3	-0.6	-1.5	-0.8	0.0	-0.9	-0.3
Alzheimer’s Disease (in father)	0.9	0.9	2.4	0.4	1.5	0.9	0.4	-1.1	1.3	0.5	1.1	-0.1	0.5	1.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.7	0.2	1.0	-1.0	0.3	-0.7	0.8	-0.4	0.7	-0.0	-0.0	1.3
Crohns Disease (2017)	0.3	0.6	1.2	0.6	0.6	-0.9	-1.0	-0.2	1.0	-0.9	0.8	0.1	1.1	-0.7
Irritable Bowel Disease (IBD)	0.3	0.7	3.1	-0.5	1.1	-0.4	-0.7	0.2	0.4	1.3	0.3	-1.8	-0.4	0.6
Ulcerative Colitis (UC)	1.1	2.1	8.8	-1.3	1.1	0.2	-0.2	0.7	-0.4	3.0	-0.3	-2.4	-1.6	1.4
Major Depression (MDD)	0.6	0.8	2.7	0.5	-1.6	0.0	-0.7	1.4	-0.6	-1.1	-0.4	0.6	0.2	-0.9
Reaction Time	0.2	0.4	1.2	0.4	0.9	0.2	-0.1	-1.1	0.6	0.4	0.8	-0.3	0.4	0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.5	-0.8	1.2	0.3	-1.0	0.1	0.6	0.4	-0.3	-1.0	-1.0	0.7
Breast Cancer	1.2	3.0	6.6	-2.0	-0.8	-1.8	2.6	-2.6	0.3	2.6	-1.2	-1.5	-1.0	0.7
Ovarian Cancer	0.4	0.6	3.0	-0.2	-0.4	-1.7	-0.1	-1.5	0.3	0.8	-0.4	-0.0	-0.1	-0.2
Prostate Cancer	0.2	0.2	0.8	0.5	-0.4	-0.0	0.3	-0.3	0.1	-0.2	0.2	0.6	0.9	-0.9
Age at First Birth	0.7	1.0	2.4	-1.4	-0.6	-0.6	0.9	-0.4	-1.3	-0.2	-1.6	-0.7	-1.5	-0.2
Bipolar Disorder (2011)	1.5	1.4	3.4	0.0	-1.1	1.4	-0.6	1.5	-0.0	-0.8	0.7	1.6	1.8	-1.8
Body Mass Index (BMI) (2010)	1.7	2.3	6.1	-1.3	-2.5	0.3	0.3	1.3	-1.7	1.3	-1.9	-1.6	-1.6	-1.6
Coronary Artery Disease (CAD)	1.1	1.4	4.0	0.4	-1.4	-0.0	1.9	0.1	-1.6	2.0	-0.7	0.8	0.5	-1.1
Crohns Disease (2012)	1.0	1.5	3.9	1.5	1.4	-1.2	-1.2	0.2	1.6	-0.7	1.4	1.0	2.0	-0.2
Mean Putamen Volume	1.2	1.3	3.9	-1.1	-1.9	-0.1	0.8	-0.8	-1.4	-0.7	-1.3	-0.3	-0.8	-2.0
Fasting Glucose	0.7	0.8	2.7	0.3	1.6	0.2	-0.3	-0.6	0.9	1.5	0.1	-0.4	-0.2	1.4
HbA1C	1.4	1.6	6.7	-0.5	0.7	1.1	-0.6	-0.5	1.4	0.1	0.8	-2.6	-0.5	2.3
HDL Cholesterol	1.0	1.7	4.3	-2.0	0.8	-1.1	0.4	-0.5	0.3	0.6	-1.1	-2.1	-1.9	1.9
LDL Cholesterol	0.5	0.8	1.6	-0.4	-0.9	1.2	1.1	1.1	-1.1	0.5	-0.4	0.2	-0.1	-1.3
Lupus	0.4	0.6	3.1	-0.4	-0.9	-1.8	0.4	-0.8	-0.6	-0.5	-0.4	0.2	-0.2	-0.8
Neuroticism (2016)	2.0	2.9	5.1	2.3	1.2	1.5	-1.7	2.2	2.0	-0.4	2.2	1.8	1.8	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.5	-0.2	-0.1	-0.7	-0.8	0.6	-0.7	0.2	0.6	0.7	0.3
Rheumatoid Arthritis	0.9	1.2	6.4	0.5	1.3	-1.6	0.8	-0.1	-0.4	-2.5	0.6	1.2	0.2	0.3
Schizophrenia (2014)	1.1	2.4	5.5	1.8	0.5	-0.4	-1.8	2.2	0.7	-1.2	1.2	2.4	1.8	-1.4
Triglycerides	0.1	0.2	0.4	0.5	-0.6	0.6	-0.4	0.6	-0.1	0.6	0.5	-0.1	0.5	-0.2
Type 2 Diabetes (T2D) (2012)	2.7	3.1	6.6	-1.8	0.2	-2.5	2.1	-2.6	-1.7	1.9	-1.6	-0.9	-2.0	0.3
Ulcerative Colitis	0.7	1.1	6.7	-0.8	-0.3	-0.5	0.6	0.2	-1.1	2.6	-0.7	-1.2	-0.7	0.2
Blood Eosinophil Count	0.5	4.0	19.6	1.0	-1.2	4.4	0.6	2.1	-2.8	-1.4	0.5	1.6	0.4	-2.0
Blood Platelet Count	0.1	1.0	3.8	0.5	-0.0	1.2	1.2	1.5	-1.9	-0.5	0.4	0.9	0.8	-0.5
Blood Red Count	1.0	10.1	27.5	-2.8	-3.3	-0.8	4.0	-1.7	-2.9	5.2	-3.9	-3.5	-3.1	-0.6
Blood White Count	2.5	18.6	45.6	-3.7	-3.5	-3.2	6.6	-4.6	-6.8	3.7	-4.2	-2.2	-3.1	-3.5
Heel T-Score	2.8	22.6	44.9	-6.5	-3.5	-2.9	4.0	-3.7	-4.3	4.0	-5.8	-6.7	-6.5	1.4
BMI	0.3	1.9	11.5	-0.0	-1.3	-0.8	-1.0	3.4	-0.5	1.0	-0.7	-1.6	-1.3	-0.4
Height	0.2	4.3	23.9	-0.2	-1.8	1.3	-1.6	-1.9	3.4	-4.9	0.1	0.1	1.0	0.3
Waist Hip Ratio (WHR)	0.8	3.8	9.1	-1.7	-1.3	-1.0	2.1	-1.5	-3.0	2.5	-2.4	-1.7	-2.1	-0.9
Systolic Blood Pressure	0.6	2.8	9.7	-1.4	-1.1	-1.4	2.1	-1.6	-0.9	3.1	-1.6	-2.0	-1.3	0.8
Smoking Status	1.4	3.4	7.2	2.0	2.5	-0.2	-2.6	2.7	1.9	-0.7	2.1	1.5	1.6	0.6
Allergy or Eczema	0.5	1.4	4.2	1.8	0.7	1.2	-0.7	0.4	1.1	0.4	2.1	1.1	1.8	-0.4
Cardiovascular Disease	0.5	1.6	4.5	-0.7	0.6	-2.0	0.9	1.4	-1.1	2.1	-1.0	-0.9	-1.5	-0.3
Hypothyroidism (self reported)	1.1	2.5	14.1	0.7	1.9	-3.8	-1.8	1.9	1.2	0.3	0.3	0.3	-0.0	-0.3
Respiratory disease	0.4	0.8	4.1	0.3	-0.4	0.5	-2.0	0.7	0.5	-1.4	0.6	-0.6	0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	-0.3	1.2	-0.6	-0.6	0.2	0.1	0.4	-0.4	-1.0	-0.9	1.3
Lung FEV1/FVC ratio	0.4	1.8	8.8	0.5	0.4	-3.0	-1.0	-2.2	1.4	-0.8	0.5	0.2	0.4	1.5
Lung FVC	0.1	0.3	2.6	-0.3	0.3	-0.8	0.1	-1.6	-0.3	0.3	-0.0	0.0	-0.1	-0.2
Neuroticism	0.1	0.4	0.8	0.9	0.8	0.4	-0.5	0.9	0.3	-0.0	0.6	0.7	0.3	-0.5
Chronotype (morning person)	2.0	4.7	10.2	-2.4	-0.8	-3.2	1.9	-2.1	-2.0	2.7	-2.3	-2.4	-2.3	0.1
Hair Pigment	0.0	0.5	1.6	-0.3	0.3	1.2	0.9	-0.2	-0.1	-1.3	0.5	0.8	0.3	-0.3
Tanning	0.2	2.1	4.0	1.7	1.6	1.6	-1.1	1.2	1.2	-1.0	2.0	1.6	1.8	0.7
Hand grip strength (left)	1.2	3.2	13.8	-0.5	-3.7	0.4	2.5	-0.9	-1.8	0.8	-1.7	0.9	-0.1	-2.6
Number of treatments/medications taken	0.4	0.8	4.3	0.1	0.5	-2.1	0.2	0.4	0.1	1.9	-0.2	-0.4	-0.4	-0.2
Average weekly spirits intake	0.8	1.0	4.6	0.0	-0.8	0.6	1.0	-0.3	-0.2	2.2	-0.2	1.2	0.5	-1.4
Sensitivity / hurt feelings	0.2	0.3	0.9	0.6	0.2	0.4	0.8	0.8	-0.9	0.7	0.5	0.2	-0.3	0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.7	0.7	-1.4	0.9	0.2	0.9	-0.9	-0.4	0.2	0.8	0.6	-1.6
Hearing difficulty/problems: Yes	0.4	0.6	1.6	-1.0	-0.0	-1.2	0.0	-1.2	0.1	-0.1	-0.6	-1.3	-0.6	0.4
Relative age of first facial hair	0.8	1.7	5.0	0.5	-0.5	2.2	-1.8	1.5	0.5	-2.1	0.1	1.6	0.7	-0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	8.4	-0.4	0.5	-0.7	-1.7	0.2	0.3	-2.9	0.2	-0.0	0.1	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.3	0.1	-0.0	-0.3	-0.3	1.1	-0.4	0.2	-0.2	0.1	0.1	-0.6
Ever had hysterectomy (womb removed)	0.9	1.0	3.1	-0.2	1.4	0.4	-1.8	1.5	0.8	-1.2	0.5	-0.2	-0.2	0.8
Systolic blood pressure, automated reading	0.3	0.8	3.5	-0.4	-1.9	0.0	0.2	-0.4	-0.2	1.6	-0.9	-0.8	-0.2	-0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.9	-0.8	0.0	0.2	0.1	-0.5	-0.6	1.2	-0.6	-1.2	-1.4	0.9
Angina	2.2	2.9	10.5	-1.7	-0.4	-1.1	2.2	-0.5	-1.2	3.2	-1.4	-2.5	-1.6	-0.1
Medication for hormone replacement therapy	0.4	0.5	1.8	0.2	-0.4	0.9	-1.1	1.4	0.5	0.1	0.5	0.1	0.6	0.0
Vitamin and mineral supplements	1.5	2.1	8.1	-1.3	-0.8	0.1	1.1	-1.9	-0.4	2.8	-1.6	-1.9	-1.0	0.2
Supplements: Zinc	0.2	0.2	0.8	0.0	0.6	0.9	0.1	-0.2	0.3	-0.5	0.4	0.1	0.2	0.6
Medication: Co-codamol	0.9	1.0	3.1	-1.4	0.6	-1.3	-0.7	0.3	-0.2	-0.2	-1.4	-1.1	-1.8	-0.4
Medication: Metformin	1.3	1.9	3.8	-1.4	-1.7	0.9	1.0	0.3	-1.9	0.9	-1.9	-1.1	-1.9	-1.1
Diabetes (father)	0.5	0.6	2.6	-0.4	0.6	-1.1	-0.9	0.3	0.2	-1.6	0.3	-0.7	-0.2	0.7
Diabetes (mother)	0.4	0.5	1.6	-0.3	-1.3	-1.1	0.2	-1.0	-0.8	-0.2	-0.5	0.1	-0.3	0.0
Severe depression (siblings)	0.3	0.3	1.0	0.7	-0.8	1.0	0.0	0.6	0.0	-0.3	0.2	0.4	0.7	-0.5
Pack years adult smoking proportion	0.7	1.1	3.2	-0.9	0.0	-1.5	0.8	-0.6	-0.7	1.4	0.1	-1.8	-1.0	1.0
Impedance of leg (right)	0.6	2.8	11.8	0.7	0.4	1.5	2.2	-3.4	-0.3	1.6	0.5	2.3	1.6	-0.1
Leg fat-free mass (left)	0.4	2.3	10.7	0.3	-1.6	-0.4	-1.6	3.3	0.5	-2.6	-0.4	-0.2	-0.4	-1.1
Trunk fat percentage	0.3	1.2	5.6	0.4	-1.3	0.7	0.4	2.4	-1.0	0.7	-0.7	0.7	-0.1	-1.8
Hand grip strength (right)	0.8	2.3	7.9	0.3	-2.8	0.0	2.2	-1.6	-0.7	0.8	-0.9	1.7	0.5	-2.1
Townsend deprivation index at recruitment	0.2	0.2	0.8	0.5	0.1	0.4	-0.2	0.7	0.4	0.3	0.9	-0.2	0.7	-0.2
Current tobacco smoking	1.1	1.8	7.7	-0.7	-0.7	-1.4	1.3	-0.2	-1.6	2.8	-1.3	-0.1	-1.2	-1.4
Average weekly fortified wine intake	1.1	1.3	5.2	-0.2	-1.0	-0.6	1.3	0.7	-1.5	0.8	-1.4	0.6	-0.4	-2.3
Maternal smoking around birth	0.7	1.1	4.6	-0.9	-2.1	0.0	0.6	-1.5	-0.8	-0.1	-1.2	-1.1	-0.3	0.7
Fed-up feelings	0.5	0.8	2.1	-0.1	-1.5	1.2	-0.2	1.1	-0.8	1.3	-0.4	0.0	-0.4	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	0.8	-1.1	-1.3	-0.6	0.5	0.3	0.5	0.2	0.7	0.9	-0.7
Relative age voice broke	1.2	1.9	6.0	1.5	0.4	1.6	-0.5	1.5	0.8	-0.7	1.1	2.4	1.6	-1.7
Taking other prescription medications	1.2	1.9	6.0	-1.5	0.3	-2.4	0.1	-0.2	-0.5	2.0	-1.3	-1.6	-1.9	0.7
Age when periods started (menarche)	0.7	1.8	5.3	1.7	0.6	0.8	-0.4	-0.5	1.9	-1.3	1.4	1.7	2.3	-0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.7	-0.6	1.5	0.5	-1.6	0.4	1.0	-0.7	-0.2	-0.7	-0.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.5	14.7	-3.2	-1.9	-1.1	2.3	-3.8	-1.8	1.8	-2.9	-3.7	-2.6	1.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.2	-0.6	-0.4	0.0	-0.4	-0.3	0.1	-0.3	-0.1	-0.5	0.1
Qualifications: CSEs or equivalent	0.3	0.4	2.0	0.4	-0.4	-0.4	-0.7	-0.6	0.6	-0.3	0.7	-0.7	0.2	1.4
Serious illness, injury or assault to yourself	1.1	1.4	2.8	-1.4	-1.0	0.1	1.4	0.3	-1.5	1.1	-1.0	-1.1	-1.3	-1.7
High blood pressure	0.7	1.9	7.0	-1.6	0.3	-0.4	1.3	0.6	-0.7	2.6	-1.4	-1.9	-1.5	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	0.9	0.4	0.9	-0.7	0.3	0.7	-0.1	1.3	1.0	0.9	-0.7
Multivitamins +/- minerals	2.6	3.4	7.9	2.3	1.2	0.9	-1.8	1.7	2.1	-1.9	2.8	1.4	2.2	0.7
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.5	-0.9	0.5	-0.2	0.0	-0.9	-0.8	0.1	0.7	0.6	-1.0
Supplements: Glucosamine	1.6	2.2	6.7	1.1	0.8	0.1	-2.6	1.5	1.8	-2.5	1.2	1.0	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.3	-1.5	0.5	0.7	1.2	-1.1	-0.6	0.2	-0.7	-1.5	-1.0	0.5
Medication: Atenolol	0.8	1.0	5.4	0.1	0.9	-0.7	1.5	0.6	-0.7	2.3	-0.3	-0.3	-0.5	-0.9
Medication: Levothyroxine sodium	0.9	1.6	5.2	0.6	0.4	-2.3	-2.1	1.5	0.8	-1.4	0.2	0.8	0.3	-1.3
Sitting height	0.2	1.5	3.7	0.2	1.6	0.9	-0.8	1.6	1.9	-1.6	0.9	-1.0	-0.3	1.3
Chronic bronchitis/emphysema (father)	1.5	1.7	4.2	-0.2	-2.1	-1.7	0.2	0.7	-1.8	0.9	-1.9	-0.0	-1.1	-1.6
High blood pressure (mother)	1.1	1.5	5.6	0.7	2.4	-0.0	-0.7	0.9	1.6	1.6	0.8	-0.3	0.1	1.9
Body mass index (BMI)	0.5	2.1	11.1	-0.1	-2.1	-0.6	-0.6	3.3	-1.2	0.7	-1.1	-1.0	-1.0	-1.5
Impedance of leg (left)	0.4	2.2	11.4	0.4	0.2	1.0	1.8	-3.4	-0.1	1.7	0.3	1.8	1.3	0.5
Leg predicted mass (left)	0.4	2.2	10.0	0.3	-1.5	-0.5	-1.6	3.2	0.5	-2.6	-0.5	-0.2	-0.5	-1.1
Trunk fat mass	0.4	1.6	7.8	0.3	-1.9	0.5	-0.0	2.8	-0.8	0.2	-0.9	0.3	-0.4	-1.9
Waist circumference	0.4	1.5	6.6	-0.1	-1.4	-0.1	0.1	2.6	-1.3	0.5	-1.0	-0.8	-1.1	-1.6
Number of incorrect matches in round	0.7	1.2	3.5	1.2	1.9	0.7	-0.9	1.9	1.0	-0.3	0.9	0.9	0.5	-0.1
Past tobacco smoking	2.0	3.7	9.2	-1.8	-2.3	-1.0	3.0	-2.1	-2.3	1.6	-2.2	-1.3	-1.8	-0.3
Alcohol usually taken with meals	0.8	1.3	10.0	0.4	0.1	-0.1	-1.0	0.3	0.1	-3.2	-0.1	1.6	0.1	-0.3
Nervous feelings	0.5	0.9	3.8	0.5	1.9	0.4	-0.5	0.2	1.5	-0.7	1.0	0.5	0.1	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	4.5	0.9	-1.4	1.3	-0.1	1.7	-0.4	0.5	0.3	0.9	1.0	-2.1
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.6	-0.2	-0.2	0.3	-0.7	0.2	0.8	-0.7	-0.9	-0.3	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.4	-0.9	0.2	0.3	0.0	-1.1	-0.5	-0.9	0.6	-0.4	-0.8
Had menopause	0.2	0.3	1.2	-0.8	0.4	-0.0	0.1	0.2	-0.0	0.2	-0.3	-1.1	-0.8	0.1
Had other major operations	0.5	0.6	2.6	0.5	0.8	-1.6	-0.9	-0.2	1.1	-0.0	0.8	-0.1	0.8	-0.2
Forced vital capacity (FVC)	0.1	0.6	2.7	0.4	0.2	0.1	-0.9	-0.3	1.0	-1.6	0.6	0.6	0.6	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	10.4	-2.7	-1.8	-0.4	1.8	-3.2	-1.5	1.4	-2.0	-3.1	-1.9	1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.9	1.2	0.1	-1.3	-1.0	1.4	-0.1	-0.8	0.4	2.2	0.7	-0.7
Qualifications: None of the above	1.0	2.2	5.6	1.8	1.2	1.2	-1.6	2.4	1.8	-0.6	1.8	1.1	1.6	0.1
Financial difficulties in last 2 years	0.5	0.6	2.3	-0.2	-1.5	-0.3	0.6	-0.1	-1.0	1.0	-0.6	-1.1	-0.3	-0.3
Mouth/teeth dental problems	2.4	3.8	11.1	0.0	-1.6	-2.4	2.4	-3.3	-1.8	0.9	-1.7	2.4	-0.3	-2.0
Heart attack	1.9	2.4	13.3	-1.3	-0.6	-1.4	1.5	-0.3	-1.0	3.7	-0.9	-1.9	-1.1	-0.8
Allergy	0.3	0.7	1.3	-0.9	0.2	-0.1	1.1	-1.0	-0.1	0.5	-0.9	-1.0	-1.0	0.9
Pain all over the body in last month	0.3	0.4	1.9	-0.6	0.2	0.3	-1.4	0.8	0.2	-0.6	-0.0	-0.3	-0.5	0.6
Diabetes (self-reported)	0.4	0.6	2.0	-0.1	1.4	0.2	-1.4	0.8	0.5	-0.4	0.1	-0.2	-0.7	1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	1.6	0.8	0.2	-1.0	1.1	0.2	0.5	1.4	1.4	1.3	0.0
Medication: Ramipril	0.9	1.1	3.7	-0.5	1.1	1.2	0.8	0.6	0.5	1.5	0.5	-1.9	-0.1	1.4
Medication: Simvastatin	0.8	1.1	4.8	0.7	2.2	-0.7	-0.5	1.1	1.2	1.1	1.2	-0.7	0.3	0.7
Fluid intelligence score	0.6	1.2	3.3	0.9	1.8	0.8	-1.4	1.0	1.5	-1.1	1.0	0.7	0.6	0.4
Illnesses of siblings	0.4	0.5	2.1	0.6	-0.0	-0.6	-0.1	0.1	-0.1	-1.3	0.5	1.5	0.9	-0.4
Neuroticism score	0.1	0.3	1.3	0.6	0.2	0.1	-0.9	1.1	0.2	-0.2	0.5	0.4	0.0	-0.3
Weight	0.4	1.9	9.7	0.2	-2.3	0.1	-1.1	3.1	-0.1	-0.9	-0.8	-0.3	-0.4	-1.6
Impedance of arm (right)	0.4	2.1	5.5	0.5	2.3	1.2	1.3	-2.2	0.8	-0.0	1.4	1.8	1.4	0.9
Arm fat percentage (right)	0.3	1.2	8.7	0.2	-1.0	0.3	-0.3	2.9	-0.8	0.7	-0.5	-0.2	-0.6	-1.1
Trunk fat-free mass	0.4	2.6	8.1	0.7	-2.3	0.2	-2.0	2.7	0.9	-2.9	-0.2	0.2	0.2	-1.6
Hip circumference	0.6	2.4	15.7	1.3	-1.1	1.0	-1.5	4.0	0.8	-0.7	0.4	0.8	0.8	-1.6
Time employed in main current job	0.3	0.4	1.5	0.1	-0.2	1.0	0.6	0.2	-0.0	0.7	-0.4	0.8	-0.5	-1.2
Alcohol intake versus 10 years previously	1.2	1.9	7.0	1.9	-0.4	0.9	-1.5	2.6	1.0	-0.2	1.1	1.1	1.4	-1.1
Father’s age at death	1.0	1.4	4.0	0.2	1.3	-1.0	-2.0	-0.7	1.6	-1.7	0.5	-0.7	0.2	1.3
Worrier / anxious feelings	0.3	0.5	3.3	-0.1	0.8	-1.8	0.1	-1.1	-0.1	-0.4	0.2	-0.4	-0.2	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	3.3	1.4	0.7	0.3	-1.8	0.9	1.3	-1.0	1.6	0.9	0.8	0.2
Falls in the last year	1.2	1.7	9.2	0.8	0.4	-0.9	-3.0	1.3	0.9	-1.9	1.1	0.6	0.5	-0.1
Hair/balding pattern: Pattern 3	1.5	2.3	5.0	-2.2	-1.6	-0.4	1.4	-1.4	-1.8	1.7	-1.7	-1.6	-1.3	-0.6
Number of live births	0.3	0.4	0.9	-0.7	-0.1	0.4	0.7	0.1	-0.8	0.8	-1.0	-0.8	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	0.6	0.8	-0.4	-1.2	-0.9	1.6	-1.4	0.9	0.5	0.7	1.4
Pulse rate	2.2	3.6	6.0	-2.3	-2.2	-1.6	1.8	-1.5	-1.8	1.5	-2.4	-2.4	-2.3	-0.1
Happiness	0.8	0.9	2.9	0.4	-0.2	-0.2	-1.4	-1.4	1.7	-0.7	0.6	0.6	0.7	1.1
Noisy workplace	1.0	1.3	6.7	-0.9	-1.3	-2.6	-0.2	-1.7	-0.6	-0.2	-0.9	-0.3	-0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.5	0.5	0.7	2.0	-1.1	0.3	1.4	-2.1	1.0	0.7	0.8	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	0.1	-0.2	0.5	0.2	0.9	-0.4	-0.9	-0.1	0.7	-0.3	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	0.3	-1.1	-0.3	0.5	0.0	-0.5	1.1	-0.2	0.7	0.4	-0.7
Asthma	0.4	0.8	4.5	0.7	-0.9	-0.1	-2.1	0.6	0.5	-0.8	0.7	0.2	1.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.0	0.4	0.1	-0.4	-1.4	1.0	1.1	-0.1	0.6	0.0	0.2	0.4
Medication: Cholesterol lowering	0.6	1.0	4.1	0.3	0.1	-0.6	0.5	2.0	-0.6	2.0	-0.3	-0.8	-0.4	-0.9
Depression (self-reported)	0.6	0.7	4.7	0.6	-0.1	-0.3	-0.6	2.2	-0.0	-1.1	0.3	0.1	0.1	-0.8
Medication: Lansoprazole	1.7	1.9	4.2	-1.3	-0.6	-0.2	1.4	-2.1	-1.4	1.6	-1.3	-1.7	-1.8	0.9
Prospective memory result	0.5	0.6	2.3	-0.7	-0.9	-0.5	1.5	-0.5	-1.2	0.3	-0.4	0.0	-0.6	-0.5
Lung cancer (father)	1.0	1.2	4.3	0.8	-0.6	1.0	1.3	1.4	-1.3	0.7	0.2	0.6	0.6	-2.1
Illnesses of mother	1.2	1.5	3.9	0.7	-0.5	1.2	-1.5	1.3	0.4	-2.0	0.8	1.4	1.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.3	0.4	0.8	0.2	-0.5	-0.9	1.1	-0.4	0.8	0.8	0.5	0.3
Pulse wave Arterial Stiffness index	0.3	0.3	1.9	0.0	-0.0	-0.4	0.9	-1.4	0.4	0.3	0.3	0.3	0.1	0.3
Impedance of arm (left)	0.6	2.9	7.1	0.7	2.7	1.4	1.5	-2.7	1.3	-0.0	1.6	2.1	1.8	1.1
Arm fat mass (right)	0.4	1.7	12.5	0.4	-1.7	0.3	-0.8	3.5	-0.5	-0.1	-0.5	-0.2	-0.5	-1.4
Trunk predicted mass	0.4	2.5	7.5	0.6	-2.3	0.2	-2.0	2.6	0.9	-2.7	-0.2	0.1	0.2	-1.5
Standing height	0.3	3.0	15.8	0.8	-0.6	1.5	-1.5	0.1	2.5	-4.0	0.7	1.5	1.3	-0.4
Length of working week for main job	0.4	0.4	2.6	-0.6	-0.4	0.0	0.2	-0.3	0.1	1.6	-0.4	-0.8	-0.5	0.3
Exposure to tobacco smoke at home	0.6	0.7	2.6	0.8	-1.6	0.9	-0.8	0.7	0.2	-0.1	0.1	0.8	1.1	-0.8
Breastfed as a baby	0.6	0.8	2.5	-0.4	-1.1	0.9	1.3	0.7	-0.9	0.2	-0.7	0.1	-0.4	-1.6
Tense / ‘highly strung’	0.2	0.3	0.7	-0.7	-0.8	-0.0	-0.1	-0.0	0.3	-0.2	-0.9	-0.9	-0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	7.4	1.3	0.0	-0.3	-1.5	2.7	0.4	-1.2	0.7	0.8	1.0	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	0.1	-0.0	-0.6	-0.6	0.9	0.6	0.4	-0.2	-0.7	-0.0	-0.3
Birth weight of first child	1.6	2.9	6.5	1.9	0.4	1.8	-0.9	0.7	0.6	-2.5	2.2	2.3	2.1	-1.5
Peak expiratory flow (PEF)	0.8	1.8	4.3	1.2	2.1	-0.9	-0.6	-0.3	1.4	-1.3	2.1	0.2	1.3	1.9
Pulse wave reflection index	0.9	1.1	3.1	1.1	1.0	0.8	-1.0	0.4	1.8	-0.3	1.5	0.9	1.1	0.7
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.3	-1.7	-1.3	-0.5	-0.5	-0.7	-0.6	1.8	-1.5	-1.5	-1.6	0.2
Loud music exposure frequency	0.6	0.6	3.0	0.2	0.6	-0.5	-0.6	-0.7	1.2	0.6	0.6	-0.4	-0.1	1.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.9	0.5	-0.3	0.3	-0.9	-0.7	0.7	-1.4	0.9	0.3	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.8	0.1	0.1	-0.6	-0.2	1.7	-0.2	-0.5	0.6	-0.5	0.7	-0.2
Blood clot in the leg (DVT)	1.0	1.3	3.5	-0.3	0.8	-1.5	1.6	0.8	-1.9	-0.4	-0.6	0.7	-0.6	-1.7
Medication: Paracetamol	0.6	1.1	3.0	1.0	0.6	-1.7	-1.4	-0.5	1.7	0.1	1.0	-0.3	1.0	0.8
Headache pain in last month	0.3	0.5	2.0	0.5	0.6	0.3	-1.4	1.2	0.5	-0.5	0.7	-0.1	-0.1	0.6
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	10.5	1.4	-0.4	2.1	-1.7	-0.5	1.7	-3.2	1.8	2.1	2.3	0.5
Glaucoma (self-reported)	0.8	0.9	3.9	0.1	1.7	0.4	0.3	1.2	0.1	2.0	0.0	-0.8	-0.8	0.6
Gout (self-reported)	0.7	1.0	2.2	1.0	1.5	1.2	-0.9	1.3	0.8	0.7	1.3	-0.2	0.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	7.8	-0.2	0.9	-2.8	-1.5	2.0	0.5	-0.4	-0.4	-0.2	-0.8	-0.8
Medication: Amlodipine	2.9	4.1	15.6	-2.1	1.3	-1.3	1.0	-1.9	0.3	4.0	-1.1	-3.0	-1.8	2.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	5.2	1.0	-0.1	-1.2	-2.3	0.7	0.9	-0.8	0.8	0.1	0.9	0.6
Birth weight	1.2	2.6	9.6	1.5	-1.0	0.6	-0.1	1.5	-0.1	-3.1	0.3	2.8	0.7	-2.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.4	-1.4	-2.1	0.1	1.4	-1.3	-1.4	1.1	-1.6	-1.4	-0.9	-0.9
High blood pressure (siblings)	0.2	0.3	1.0	-0.2	-0.8	0.8	0.5	0.2	-0.3	1.0	-0.5	-0.2	-0.3	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	0.5	0.3	0.9	-0.2	-0.6	0.8	-0.5	0.7	1.2	0.7	-0.4
Body fat percentage	0.3	1.4	4.9	0.2	-1.6	0.4	0.5	2.2	-1.3	1.2	-0.9	0.3	-0.4	-1.7
Leg fat percentage (right)	0.6	2.0	4.4	0.3	-2.1	0.7	0.8	2.0	-1.9	1.9	-1.1	0.3	-0.4	-2.0
Arm fat-free mass (right)	0.5	2.5	9.9	0.3	-3.1	-0.1	-1.3	2.6	-0.1	-1.9	-1.2	-0.1	-0.4	-2.0
Exposure to tobacco smoke outside home	0.5	0.7	1.9	0.5	-1.4	-1.1	-0.8	0.7	0.2	0.3	0.4	-0.1	0.9	-1.4
Comparative body size at age 10	0.4	1.1	2.7	-1.0	-1.1	-0.2	-1.3	1.6	-0.4	1.0	-0.9	-1.6	-1.1	-0.6
Number of full brothers	0.7	0.8	1.8	-1.0	-1.3	1.3	0.1	0.6	0.0	0.0	-1.3	-1.1	-0.8	-0.9
Worry too long after embarrassment	0.7	1.1	3.0	-1.1	1.1	0.1	-0.2	-1.6	0.2	-0.5	0.3	-1.5	-1.1	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.9	-0.1	-0.1	-1.4	-0.1	1.1	-0.5	0.0	-0.3	-0.3	-0.6	-1.0
Wheeze or whistling in the chest in last year	2.8	5.0	9.1	-2.9	-2.4	-2.7	1.2	-1.1	-2.0	2.2	-2.5	-3.0	-2.7	0.0
Number of children fathered	0.6	0.7	3.5	-0.4	-1.9	0.1	0.6	-1.4	-0.3	-0.1	-1.1	-0.2	0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.3	0.5	0.3	-1.1	-0.9	0.7	0.3	-0.2	0.6	0.5	0.4	0.7
Age at first live birth	0.7	1.2	4.2	0.4	1.2	-1.1	-0.5	-2.1	1.1	-1.0	0.8	0.6	0.9	1.3
Pulse wave peak to peak time	0.3	0.3	1.7	0.1	-0.2	0.4	-1.1	1.3	-0.2	-0.6	-0.2	-0.2	0.1	-0.3
Health satisfaction	0.4	0.5	3.0	-0.3	-1.7	-1.1	-0.3	-0.2	-0.6	0.8	-0.4	-0.1	-0.2	-0.6
Shortness of breath walking on level ground	0.6	0.7	2.5	-0.6	-1.6	-0.7	0.3	0.7	-1.1	0.8	-0.5	-0.5	-0.7	-0.9
Qualifications: College or University degree	0.5	1.7	7.0	-1.3	0.9	-0.7	1.1	-2.6	0.5	-0.9	-0.1	-1.2	-0.1	2.3
Eye problems/disorders: None of the above	0.7	0.8	2.8	-0.7	-1.2	-0.7	1.1	-1.7	-0.5	-0.6	-1.0	0.2	-0.3	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.9	-0.3	-0.1	-1.3	0.7	-1.4	0.5	0.9	0.1	-0.8	0.2	1.4
Emphysema/chronic bronchitis	0.4	0.5	3.6	-0.2	-0.5	-1.9	-0.1	-0.7	-0.0	0.2	0.1	-0.4	0.6	0.1
Medication for pain relief, constipation, heartburn	0.8	1.3	6.6	-0.0	-0.8	2.6	-0.3	0.0	-0.5	-2.2	0.0	1.4	0.4	-0.1
Neck or shoulder pain in last month	0.4	0.6	1.4	-0.3	0.9	-0.5	-0.4	-1.2	1.0	0.7	0.7	-0.8	0.1	1.0
Medication: Blood pressure	2.1	3.8	14.2	-1.7	1.0	-2.3	1.7	-0.1	-1.1	3.8	-1.9	-2.2	-2.3	0.5
Angina (self-reported)	2.2	2.9	13.4	-1.4	-0.5	-0.7	2.5	-0.4	-1.2	3.7	-1.2	-2.1	-1.2	-0.4
Migraine (self-reported)	1.5	1.9	4.0	1.8	1.6	0.9	-0.8	1.2	1.4	1.2	1.8	0.6	2.0	0.8
Medication: Ibuprofen	0.9	1.1	4.3	0.6	0.6	-0.7	-2.1	1.4	1.6	-0.7	0.8	0.3	0.2	0.8
Medication: Allopurinol	0.7	0.9	3.2	0.3	1.3	0.1	-0.9	-0.1	1.4	0.3	0.9	-1.2	-0.1	1.8
Medication: Omeprazole	0.9	1.1	4.8	0.9	0.2	-2.2	-0.6	-1.3	1.1	-0.9	0.3	1.2	0.7	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	2.2	1.0	-0.2	0.3	-1.3	1.5	0.8	0.4	0.7	0.7	0.8	0.2
Mean time to correctly identify matches	0.4	0.8	2.0	0.9	1.4	-0.0	0.3	-1.0	0.8	0.9	1.3	-0.4	0.8	0.8
Heart disease (mother)	0.7	0.9	4.2	-0.3	0.8	-0.4	0.4	-0.0	-0.4	2.1	0.2	-1.4	-0.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	7.0	-0.2	1.4	-0.8	-0.1	-0.1	0.8	2.6	0.4	-1.6	-0.3	2.5
Whole body fat mass	0.4	1.5	6.9	0.1	-2.1	0.3	-0.1	2.6	-0.9	0.2	-1.1	0.0	-0.6	-1.8
Leg fat mass (right)	0.5	2.0	8.2	0.4	-2.4	0.1	0.2	2.9	-1.4	0.7	-1.2	0.0	-0.5	-1.9
Arm predicted mass (right)	0.4	2.2	7.6	0.4	-2.8	-0.2	-1.5	2.5	0.2	-2.0	-0.8	-0.2	-0.2	-1.7
Pulse rate, automated reading	1.5	5.0	11.8	-2.1	-2.5	-1.3	3.4	-1.0	-3.2	1.1	-2.6	-2.0	-2.2	-1.4
Alcohol intake frequency.	0.7	1.5	7.2	-0.9	-0.6	-0.1	1.3	-0.8	-0.6	2.7	-1.1	-1.7	-1.2	-0.4
Comparative height size at age 10	0.3	1.6	9.3	-0.9	-3.0	0.1	1.2	-1.5	-0.8	-0.4	-1.3	0.1	-0.4	-1.3
Number of full sisters	1.1	1.3	3.3	1.0	-1.2	1.2	-1.3	1.8	0.2	-0.5	0.7	0.3	1.4	-1.7
Suffer from ‘nerves’	1.3	2.1	4.2	1.8	1.5	1.4	-1.0	2.0	1.4	-1.5	1.8	1.2	1.1	0.3
Overall health rating	0.9	2.0	6.0	-1.2	-1.1	-1.9	1.0	-0.3	-1.3	2.4	-1.3	-1.9	-1.2	-0.7
Chest pain or discomfort	0.5	0.7	2.0	0.1	-1.0	-0.4	0.8	1.2	-1.4	-0.0	-0.4	-0.3	0.3	-1.4
Had major operations	3.3	3.8	8.3	2.5	0.7	0.2	-2.7	1.9	1.7	-1.9	1.5	2.9	2.4	-1.2
Age at last live birth	0.8	1.1	3.2	0.6	1.8	-0.0	-0.5	-0.5	1.7	-0.3	1.1	0.2	1.1	1.7
Family relationship satisfaction	0.8	1.0	4.2	-0.4	-2.0	-1.1	0.2	-2.0	0.3	0.9	-0.5	-0.3	0.2	0.4
Leg pain on walking	0.3	0.4	2.4	0.2	-0.9	-1.6	-0.6	-0.5	0.1	0.2	0.2	-0.1	0.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	0.3	-0.0	-0.7	0.3	-0.1	0.1	1.0	-0.1	0.0	-0.2	-0.5
Commuting to job workplace: Car/motor vehicle	1.7	1.9	8.7	1.5	-0.2	3.0	-0.8	2.1	0.6	0.4	1.0	1.4	1.4	-0.1
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	5.9	1.1	1.4	-1.8	-2.4	-0.2	1.9	-1.7	1.0	1.0	1.3	1.6
Medication: Aspirin	2.8	3.7	19.3	-1.2	0.4	-0.5	2.6	-0.3	-1.0	4.4	-1.2	-2.7	-1.4	-0.8
Supplements: Vitamin C	0.6	0.7	2.1	0.4	0.3	0.7	0.0	1.4	-0.5	-1.1	0.2	1.3	0.1	-1.2
Knee pain experienced in last month	0.2	0.3	1.0	0.3	-0.9	-1.0	-0.4	0.4	-0.5	0.2	-0.1	-0.3	0.2	-0.8
Hypertension (Self-reported)	0.6	1.7	5.6	-1.4	0.9	-1.1	1.0	0.8	-0.6	2.4	-1.1	-1.9	-1.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.2	1.8	1.6	-1.7	-1.0	-1.2	1.8	0.4	1.6	0.9	1.1	0.7
Illnesses of father: Heart disease	0.8	1.2	4.5	-0.8	1.1	-0.4	1.4	-1.2	-0.4	2.1	0.2	-0.8	-0.5	1.3
Illnesses of siblings: Diabetes	0.5	0.7	2.5	-1.0	0.6	-0.7	0.7	0.2	0.1	0.5	-0.3	-1.6	-1.4	0.7
Smoking status: Previous	3.7	5.5	12.8	2.1	2.9	1.2	-3.6	2.2	3.0	-1.9	2.9	1.1	2.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	7.1	-0.3	-2.7	-0.7	0.5	-0.8	-0.6	-0.5	-1.1	0.8	-0.1	-1.6
Whole body fat-free mass	0.5	2.6	9.1	0.5	-2.2	-0.1	-2.0	3.0	0.7	-2.9	-0.4	-0.1	-0.1	-1.4
Leg fat-free mass (right)	0.5	2.5	11.2	0.2	-1.4	-0.6	-2.0	3.3	0.8	-2.8	-0.4	-0.5	-0.6	-0.6
Arm fat percentage (left)	0.2	0.9	6.5	0.1	-0.8	0.2	0.0	2.6	-0.8	0.9	-0.5	-0.3	-0.6	-0.9
Average weekly red wine intake	0.4	0.5	2.6	-0.5	0.6	-1.1	0.0	-1.6	0.2	-0.4	-0.1	-0.4	-0.2	0.9
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.6	-1.2	0.1	1.1	-0.3	-1.9	0.4	1.4	0.1	-1.9	-1.1	2.4
Mood swings	0.5	0.9	3.2	-0.2	-1.8	1.4	0.2	1.0	-1.1	0.8	-0.8	0.3	-0.2	-1.0
Loneliness, isolation	0.3	0.4	1.9	0.8	-0.5	0.4	-0.4	1.4	-0.2	0.6	0.2	0.5	0.5	-0.8
Long-standing illness, disability or infirmity	0.9	1.4	7.9	-1.3	-0.3	-2.8	-0.5	-0.2	-0.4	0.2	-1.0	-1.6	-1.1	0.3
Ever had bowel cancer screening	0.5	0.6	3.5	0.3	1.9	-1.4	0.2	0.3	0.2	-0.5	0.7	0.5	0.3	-0.1
Diabetes diagnosed by doctor	0.3	0.5	1.5	-0.8	0.3	0.1	-0.5	0.2	-0.3	0.5	-0.6	-1.1	-1.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.6	2.1	0.7	1.1	-1.9	2.1	1.3	0.3	1.5	1.7	2.0	-0.6
Friendships satisfaction	0.4	0.5	1.8	-0.7	-1.3	-0.0	-0.4	-1.1	-0.1	-0.5	-0.7	-0.4	-0.9	0.7
Qualifications: nursing, teaching	0.5	0.7	3.8	-0.5	0.6	1.9	-0.8	1.2	0.3	-0.9	0.1	-0.5	-0.3	0.7
Commuting to job workplace: Walk	0.7	0.7	4.0	0.5	0.5	-2.0	0.2	-1.1	-0.4	-0.7	0.2	1.0	-0.2	0.5
Eye problems/disorders: Cataract	0.9	1.0	3.2	0.4	1.8	0.0	-1.1	0.8	1.0	-0.3	1.6	-0.3	0.9	1.3
Mouth/teeth dental problems: Mouth ulcers	8.1	12.8	58.8	-1.0	1.9	7.7	-2.6	5.5	1.7	-2.2	1.9	-4.4	-0.9	2.9
Medication for cholesterol	0.9	1.3	4.2	1.2	-0.8	-0.6	0.4	-0.3	-0.2	-2.0	0.3	1.9	1.0	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.1	0.4	0.5	-0.1	-0.5	-0.4	0.5	1.0	0.3	0.3	0.9	-0.3
Back pain experienced in last month	1.3	1.9	4.4	1.5	0.9	-0.7	-1.8	-1.1	2.0	-0.8	2.1	0.8	1.6	1.0
Mineral and other dietary supplements	1.5	2.0	6.4	-1.0	-0.9	0.7	2.2	-1.6	-1.3	2.5	-1.7	-0.9	-0.5	-0.5
Breast cancer (self-reported)	0.6	0.7	2.3	-0.7	0.8	1.5	-0.2	-0.3	0.4	0.0	0.4	-1.0	-0.8	1.4
Asthma (self-reported)	0.4	0.8	3.6	0.8	-0.6	-0.3	-1.9	0.3	0.6	-0.6	0.8	0.2	1.1	0.8
Osteoporosis (self-reported)	1.4	1.7	5.1	0.8	0.6	1.0	-2.1	-0.6	1.8	-2.3	0.7	1.5	0.2	0.9
Osteoarthritis (self-reported)	3.0	3.9	9.4	-1.9	-3.1	-2.1	0.7	0.6	-2.5	0.9	-2.5	-1.5	-1.8	-2.5
Medication: Aspirin	1.9	2.5	15.5	-0.5	0.9	-0.1	2.1	0.4	-0.6	3.9	-0.5	-2.2	-0.7	-0.5
Medication: Gliclazide	1.5	1.7	4.8	0.5	2.1	0.1	-0.9	-0.1	1.6	1.7	1.0	-1.5	0.3	2.2
Illnesses of father: None of the above (group 1)	1.5	1.9	6.1	1.5	-1.1	1.3	-1.6	0.5	0.8	-2.5	1.0	1.6	1.5	-0.3
Smoking status: Current	1.0	1.5	5.5	-0.6	-0.7	-1.4	1.3	-0.1	-1.5	2.3	-1.1	0.1	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.7	-0.7	0.8	-0.8	-0.3	-1.3	-0.0	-0.2	0.1	-0.1	-0.7	0.7
Whole body water mass	0.5	2.7	9.5	0.4	-2.2	-0.1	-2.1	3.1	0.7	-2.9	-0.4	-0.2	-0.2	-1.3
Leg predicted mass (right)	0.5	2.5	11.1	0.2	-1.5	-0.6	-2.0	3.3	0.8	-2.8	-0.4	-0.5	-0.5	-0.7
Arm fat mass (left)	0.4	1.6	10.8	0.3	-1.6	0.5	-0.8	3.3	-0.4	-0.2	-0.6	-0.2	-0.5	-1.3
Number of self-reported non-cancer illnesses	0.3	0.5	3.6	0.4	0.1	0.0	-0.4	1.9	-0.5	0.5	-0.2	0.3	-0.3	-0.8
Average weekly champagne plus white wine intake	1.5	2.0	6.8	2.0	0.2	0.1	-1.0	1.2	0.3	-1.4	1.5	2.6	1.7	-1.3
Miserableness	1.4	2.4	5.5	1.8	0.3	2.3	-2.2	1.9	1.8	0.3	1.7	0.8	1.4	0.2
Guilty feelings	0.2	0.4	1.5	-0.6	-0.3	0.1	-0.9	1.2	0.2	-0.6	-0.4	-0.3	-0.8	-0.2
Wears glasses or contact lenses	0.7	0.8	1.9	1.2	0.1	1.2	-0.3	-0.4	0.5	-0.8	1.1	1.2	1.4	0.3
Ever taken oral contraceptive pill	0.4	0.4	1.2	-0.3	0.7	-0.2	-0.6	-0.5	1.0	-1.1	0.1	0.0	0.3	1.0
Hearing aid user	0.3	0.4	1.2	-0.4	-1.1	0.0	-0.8	0.5	-0.2	-0.7	-0.7	-0.5	-0.6	-0.2
Mother’s age at death	0.5	0.6	2.8	-0.7	0.3	1.7	-0.2	-1.3	-0.4	-0.3	-0.4	-0.3	-0.9	0.6
Financial situation satisfaction	1.7	2.1	8.5	-0.3	-1.6	-1.5	1.8	-2.9	-0.8	2.1	-0.7	-0.3	0.0	-0.3
Tinnitus: Yes, now most or all of the time	1.4	1.7	3.4	-1.1	-1.3	-1.5	1.5	-1.8	-1.7	0.1	-1.2	-1.2	-1.2	-0.0
Commuting to job workplace: Public transport	0.4	0.5	1.9	0.5	-0.5	-1.4	-0.1	-0.2	-0.0	-0.6	-0.2	0.8	0.6	-1.1
Eye problems/disorders: Glaucoma	0.5	0.6	3.8	-0.1	0.9	0.6	0.2	0.8	-0.2	1.9	-0.5	-0.5	-0.7	0.3
Medication: Blood pressure	1.4	2.7	7.7	-2.1	0.8	0.2	1.5	-0.8	-0.5	2.4	-1.1	-2.8	-1.9	1.8
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.8	0.1	1.1	-1.2	-1.6	-1.4	1.6	-1.2	1.3	-0.8	0.3	1.7
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.5	1.5	1.3	-0.7	-1.7	1.9	1.2	-1.1	1.8	0.5	0.5	0.7
High cholesterol (Self-reported)	0.4	0.7	3.5	1.0	0.6	0.2	0.0	1.9	0.4	1.0	0.5	0.4	0.6	-0.9
Medication: Bendroflumethiazide	2.7	4.0	11.8	-2.5	-0.3	-1.0	1.8	-0.5	-1.8	3.4	-2.7	-2.0	-2.7	0.3
Medication: Paracetamol	0.6	0.9	3.5	1.1	0.5	-1.9	-0.9	-0.5	1.3	-0.5	0.9	0.3	1.0	0.1
Medication: Lisinopril	1.8	2.3	4.6	-1.7	-0.8	-0.9	1.9	-0.6	-2.0	1.7	-2.0	-1.2	-2.1	-0.4
Medication: Atorvastatin	1.3	1.6	4.9	-0.9	-0.2	1.0	1.2	-0.0	-1.0	2.2	-1.5	-0.9	-2.2	-0.7
Illnesses of father: High blood pressure	0.5	0.7	1.6	-1.2	-1.3	0.0	0.9	-0.7	-0.4	0.4	-0.8	-1.2	-0.6	-0.3
Alcohol drinker status: Never	1.9	2.3	7.1	-1.8	-0.4	-1.5	1.2	-1.3	-1.3	1.5	-1.3	-2.7	-1.8	0.5
Ever smoked	0.9	1.6	4.5	1.0	1.5	0.2	-2.1	1.6	1.5	-1.2	1.1	1.0	1.2	-0.2
Basal metabolic rate	0.5	2.6	10.2	0.5	-2.3	-0.1	-1.9	3.2	0.6	-2.6	-0.4	-0.1	-0.1	-1.4
Leg fat percentage (left)	0.6	2.1	5.3	-0.2	-2.3	0.0	0.7	2.0	-1.9	2.0	-1.4	-0.2	-0.8	-1.7
Arm fat-free mass (left)	0.5	2.8	11.4	-0.1	-3.4	-0.1	-1.4	2.8	-0.3	-1.8	-1.2	-0.7	-0.7	-1.8
Number of operations (self-reported)	1.0	1.5	4.0	1.7	0.9	-0.9	-1.5	0.8	1.9	0.2	1.1	0.9	2.0	-0.4
Average weekly beer plus cider intake	1.6	2.4	7.7	0.8	1.6	0.4	-1.7	0.7	2.3	-1.0	1.8	-1.2	0.9	2.8
Irritability	0.2	0.3	0.9	-0.2	-0.9	-0.5	-0.5	0.1	-0.1	0.7	-0.6	-0.4	-0.2	-0.6
Risk taking	0.9	1.3	4.5	1.4	-1.2	-0.2	0.3	1.7	-0.6	0.0	0.5	1.4	1.0	-2.1
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.1	1.7	0.8	0.1	-0.4	0.1	1.2	-1.9	1.4	2.0	1.6	-0.3
Fractured/broken bones in last 5 years	2.1	2.7	8.3	1.6	0.4	0.5	-2.9	2.5	1.0	-1.8	1.5	1.9	1.2	-0.6
Age started oral contraceptive pill	1.1	1.4	2.9	-1.5	-0.4	-1.6	0.8	-1.7	-0.2	0.1	-1.6	-1.3	-1.5	-0.4
Diastolic blood pressure, automated reading	0.3	1.0	3.9	0.2	-2.0	-1.2	1.4	-0.8	-0.1	1.1	-0.8	0.0	0.1	-0.9
Ever depressed for a whole week	0.9	1.1	2.8	1.2	0.3	0.4	-0.9	1.7	0.5	-1.4	0.8	1.7	0.8	-0.6
Unable to work because of sickness or disability	0.7	0.9	2.9	-1.3	-0.1	-0.9	0.2	-0.1	-0.9	0.1	-1.4	-1.1	-1.7	-0.4
Commuting to job workplace: Cycle	0.5	0.6	1.2	0.8	1.1	-1.1	-0.6	-0.7	0.6	-0.9	0.6	0.9	0.4	0.1
Myopia	1.4	2.1	9.4	-0.2	3.1	-0.5	-0.5	-0.9	2.1	-1.6	1.3	-0.7	0.2	1.7
Vascular/heart problems diagnosed by doctor	1.3	3.6	11.7	2.1	0.2	1.0	-1.9	-0.5	1.5	-3.4	2.2	2.5	2.2	0.3
Cholesterol lowering medication	0.5	0.8	2.0	-0.2	1.3	0.9	-0.1	-0.2	0.8	1.4	0.5	-1.4	-0.4	1.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	8.4	0.9	0.3	-2.9	0.3	-1.3	0.9	0.0	0.1	1.0	0.6	-0.5
Pain experienced in last month	0.7	1.1	3.2	0.4	-0.5	0.0	1.7	1.0	-1.0	0.5	-1.0	1.6	0.2	-1.8
Supplements: Calcium	0.5	0.5	2.4	-0.6	-0.4	-0.2	-1.6	0.3	0.6	-1.6	-0.1	-0.0	-0.1	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	1.4	-0.2	-0.2	-0.3	1.2	-0.1	-0.4	0.4	-0.4	-0.3	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	2.2	2.9	16.0	-1.4	-0.4	-1.4	1.7	-0.5	-0.9	4.0	-1.0	-2.1	-1.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	5.2	-0.6	0.2	-1.0	1.9	0.9	-2.3	-0.3	-1.0	0.5	-1.0	-2.1
Heart disease (siblings)	0.6	0.7	4.1	0.5	1.3	0.3	0.0	0.2	0.7	2.0	0.6	-0.6	-0.0	0.6
Alcohol drinker status: Previous	0.5	0.6	2.9	-0.3	0.2	-1.1	1.0	-0.9	-0.8	1.7	-0.5	0.4	-0.3	-0.2
Pack years of smoking	0.8	1.2	3.8	-1.1	-0.2	-1.5	0.8	-0.7	-0.7	1.2	-0.2	-2.0	-1.3	0.9
Impedance of whole body	0.5	2.5	10.8	0.4	1.3	1.5	2.2	-3.3	0.2	1.0	0.8	2.0	1.4	0.6
Leg fat mass (left)	0.5	2.1	8.0	0.1	-2.6	-0.3	0.1	2.8	-1.4	0.7	-1.4	-0.2	-0.8	-1.8
Arm predicted mass (left)	0.5	2.6	9.5	0.4	-3.1	-0.0	-1.8	2.9	-0.0	-1.9	-0.8	-0.4	-0.3	-1.8