[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor :

chr10:103,313,599-105,850,787

Best TWAS P=2.13e-15 · Best GWAS P=1.2e-16 conditioned to 0.00407

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Breast Mammary Tissue (Female) CYP17A1-AS1 0.14 0.01 lasso 11 0.00 4.7e-01 7.2 5.4 8.1e-08 0.87 0.03 0.61 FALSE
2 GTEx Cells Transformed fibroblasts GBF1 0.07 0.00 enet 2 0.00 1.4e-01 5.1 5.2 2.5e-07 0.78 0.05 0.47 FALSE
3 GTEx Cells Transformed fibroblasts SUFU 0.07 0.04 lasso 3 0.04 3.5e-04 7.2 7.0 1.8e-12 0.83 0.38 0.16 FALSE
4 GTEx Testis NT5C2 0.20 0.03 lasso 8 0.08 2.8e-04 7.2 7.9 2.1e-15 0.86 0.04 0.91 TRUE
5 GTEx Testis CYP17A1-AS1 0.14 0.08 enet 5 0.10 2.3e-05 7.1 -7.2 4.2e-13 -0.97 0.05 0.93 FALSE
6 GTEx Thyroid WBP1L 0.26 0.10 enet 9 0.13 2.1e-10 3.9 -6.0 2.3e-09 -0.80 0.66 0.34 FALSE
7 ROSMAP Brain Pre-frontal Cortex CNNM2 0.11 0.08 lasso 3 0.07 2.2e-09 7.6 7.6 2.8e-14 0.99 0.02 0.98 FALSE
8 ROSMAP Brain Pre-frontal Cortex USMG5 0.04 0.03 lasso 9 0.03 1.6e-04 3.6 -6.0 1.7e-09 -0.64 0.04 0.94 FALSE
9 YFS Blood NT5C2 0.13 0.10 bslmm 382 0.11 7.3e-35 8.1 7.7 1.0e-14 0.94 0.01 0.99 FALSE
10 The Cancer Genome Atlas Stomach Adenocarcinoma AS3MT 0.05 0.02 blup 62 0.03 2.1e-03 -2.7 6.3 4.0e-10 0.72 0.02 0.32 FALSE