Hub : Genes

USMG5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0280 0.0140 0.01300 0.009 0.004 0.000 0.005 0.001 2.8e-02 1.1e-01 0.3200 0.0750 0.21000
2 ROSMAP Brain Pre-frontal Cortex 0.0414 0.0171 0.00076 0.034 0.016 0.013 0.018 0.027 2.8e-05 3.6e-03 0.0072 0.0021 0.00016
3 YFS Blood 0.4975 0.0393 0.00000 0.712 0.684 0.712 0.709 0.714 0.0e+00 6.3e-318 0.0000 0.0000 0.00000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.4 0.9 0.2 1.0 0.3
Bipolar Disorder or Schizophrenia 4.6 11.2 19.8 3.1 4.5 -2.0
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 0.3 0.7 -0.3
Depression (Nagel 2018) 2.1 3.1 5.0 1.6 2.2 -1.4
Intelligence (Savage-Jansen 2018) 1.8 5.5 6.4 -2.1 -2.4 2.5
Neuroticism (Nagel 2018) 4.3 10.1 15.3 2.9 3.9 -2.5
Schizophrenia (2018) 7.6 15.7 24.6 3.8 5.0 -2.8
Schizophrenia vs Biploar Disorder 7.5 9.9 13.0 3.6 3.4 -2.2
Worry (Nagel 2018) 7.9 16.6 23.0 4.4 4.8 -2.7
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.2 -0.4 0.3
Alzheimer’s Disease (in father) 1.5 1.6 2.2 -1.3 -1.0 1.5
Alzheimer’s Disease (including proxy) 0.2 0.2 0.3 -0.6 -0.5 0.5
Crohns Disease (2017) 1.0 2.2 3.0 1.3 1.4 -1.7
Irritable Bowel Disease (IBD) 0.0 0.1 0.1 0.1 -0.2 0.3
Ulcerative Colitis (UC) 1.5 2.8 4.2 -1.2 -1.7 2.0
Major Depression (MDD) 4.5 5.5 8.1 2.3 2.8 -1.8
Reaction Time 0.1 0.3 0.5 0.6 0.7 0.1
Verbal and Numeric Reasoning (VNR) 1.4 3.3 4.4 -1.4 -2.1 1.9
Breast Cancer 1.1 2.5 3.0 -1.7 -1.5 1.5
Ovarian Cancer 0.0 0.1 0.1 0.3 -0.2 -0.1
Prostate Cancer 0.2 0.3 0.8 -0.9 -0.2 0.2
Age at First Birth 9.2 13.4 13.8 -3.6 -3.7 3.7
Bipolar Disorder (2011) 1.3 1.2 3.3 0.3 1.8 -0.5
Body Mass Index (BMI) (2010) 0.5 0.6 1.4 -0.4 -1.2 -0.5
Coronary Artery Disease (CAD) 7.9 9.4 11.7 3.4 3.4 -2.3
Crohns Disease (2012) 5.9 9.5 11.5 3.0 2.8 -3.4
Mean Putamen Volume 0.4 0.4 0.7 -0.2 -0.8 0.8
Fasting Glucose 0.4 0.5 0.9 -0.3 -1.0 0.6
HbA1C 0.1 0.1 0.3 0.1 -0.0 0.5
HDL Cholesterol 1.2 1.9 2.6 1.0 1.6 -1.5
LDL Cholesterol 0.1 0.1 0.2 -0.5 -0.2 0.2
Lupus 0.6 0.9 1.9 -1.4 -0.7 0.4
Neuroticism (2016) 0.1 0.2 0.4 -0.0 0.5 0.6
Primary Biliary Cirrhosis 1.8 2.6 2.9 1.7 1.4 -1.7
Rheumatoid Arthritis 0.6 0.8 1.0 0.7 0.9 -1.0
Schizophrenia (2014) 5.6 12.4 21.3 3.3 4.6 -2.2
Triglycerides 0.2 0.3 0.8 0.1 -0.4 0.9
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.4 0.5 0.6 -0.5
Ulcerative Colitis 0.1 0.2 0.3 0.6 0.4 -0.0
Blood Eosinophil Count 0.2 1.8 3.1 -1.8 -0.8 1.3
Blood Platelet Count 0.1 0.8 1.6 -0.1 0.8 -1.3
Blood Red Count 0.2 1.6 4.4 -0.1 2.1 0.7
Blood White Count 3.3 24.8 28.6 5.1 5.3 -4.4
Heel T-Score 2.4 18.8 24.6 -4.1 -5.0 3.9
BMI 1.2 6.9 12.5 -2.7 -3.5 1.0
Height 0.2 3.0 6.7 -2.6 -1.5 -0.2
Waist Hip Ratio (WHR) 1.0 4.3 5.0 1.9 2.2 -2.1
Systolic Blood Pressure 18.0 90.2 139.2 9.0 11.8 -7.0
Smoking Status 4.3 10.3 19.4 2.2 2.6 -4.4
Allergy or Eczema 1.7 4.6 5.2 -2.3 -2.1 2.0
Cardiovascular Disease 5.7 18.8 34.5 3.6 5.9 -3.0
Hypothyroidism (self reported) 0.1 0.1 0.2 -0.3 -0.5 -0.1
Respiratory disease 1.4 3.2 3.6 -1.9 -1.9 1.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 0.7 -0.2 -0.8
Lung FEV1/FVC ratio 0.1 0.4 1.3 -0.3 -0.1 -1.1
Lung FVC 3.3 17.0 20.2 4.3 4.5 -3.5
Neuroticism 6.1 14.6 20.6 3.8 4.5 -2.9
Chronotype (morning person) 4.2 9.7 12.1 -2.8 -3.0 3.5
Hair Pigment 0.0 1.0 1.5 0.8 1.2 -0.9
Tanning 0.2 2.5 4.7 1.2 1.2 -2.2
Hand grip strength (left) 0.2 0.5 1.3 0.6 0.1 -1.1
Number of treatments/medications taken 1.4 2.4 4.2 1.3 2.1 -1.2
Average weekly spirits intake 4.6 5.7 8.7 2.2 1.9 -2.9
Sensitivity / hurt feelings 3.2 5.4 7.6 1.9 2.8 -2.2
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.5 0.5 1.2 -0.6
Hearing difficulty/problems: Yes 0.1 0.1 0.3 0.3 0.5 0.1
Relative age of first facial hair 2.3 4.7 7.5 1.5 2.0 -2.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 0.5 0.8 0.1
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.4 -0.3 0.2 0.6
Ever had hysterectomy (womb removed) 0.9 1.0 1.4 -0.7 -1.0 1.2
Systolic blood pressure, automated reading 19.1 55.4 79.0 7.2 8.9 -6.0
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.0 0.8 0.9 -1.0
Angina 5.3 7.0 8.4 2.8 2.9 -2.2
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.1 0.2 -0.5
Vitamin and mineral supplements 0.9 1.2 2.1 -1.5 -0.8 1.0
Supplements: Zinc 0.7 0.8 1.1 1.1 0.6 -0.9
Medication: Co-codamol 3.8 4.5 4.7 2.2 2.1 -2.0
Medication: Metformin 0.3 0.4 0.8 -0.3 -0.9 0.4
Diabetes (father) 1.0 1.2 1.7 1.1 0.8 -1.3
Diabetes (mother) 0.3 0.4 0.9 0.4 0.2 -0.9
Severe depression (siblings) 4.5 5.1 7.8 1.8 2.8 -2.0
Pack years adult smoking proportion 5.5 8.3 12.4 2.1 2.9 -3.5
Impedance of leg (right) 6.3 30.8 41.4 5.6 6.4 -4.4
Leg fat-free mass (left) 2.7 14.1 22.0 -4.0 -4.7 2.1
Trunk fat percentage 0.1 0.5 1.1 -0.5 -1.1 -0.4
Hand grip strength (right) 0.7 1.8 3.4 1.3 0.6 -1.8
Townsend deprivation index at recruitment 0.3 0.5 1.1 0.6 0.1 -1.0
Current tobacco smoking 3.6 5.9 9.7 2.1 1.9 -3.1
Average weekly fortified wine intake 1.3 1.6 1.7 -1.1 -1.3 1.3
Maternal smoking around birth 2.4 3.5 4.6 2.0 1.4 -2.2
Fed-up feelings 0.1 0.2 0.6 -0.8 -0.1 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.0 0.6 1.0 -0.9
Relative age voice broke 3.4 5.2 6.6 1.9 2.3 -2.6
Taking other prescription medications 0.1 0.1 0.2 -0.2 -0.1 0.5
Age when periods started (menarche) 0.3 0.7 1.2 -0.9 -1.1 -0.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.4 -0.4 -0.1 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.6 -0.7 0.4
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.3 0.9 1.0 -1.5
Qualifications: CSEs or equivalent 0.8 1.1 1.3 -1.0 -1.1 0.9
Serious illness, injury or assault to yourself 7.0 8.5 9.0 3.0 3.0 -2.7
High blood pressure 6.5 18.0 32.4 3.3 5.7 -3.3
Hayfever, allergic rhinitis or eczema 1.2 2.6 2.9 -1.7 -1.5 1.6
Multivitamins +/- minerals 0.0 0.0 0.0 0.2 -0.0 0.2
Stomach or abdominal pain in last month 1.6 2.0 2.3 -1.3 -1.5 1.4
Supplements: Glucosamine 1.2 1.5 1.8 1.3 1.0 -1.3
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.1 -0.5 0.4
Medication: Atenolol 4.3 5.3 6.7 2.5 2.6 -1.8
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.1 0.5 -0.2
Sitting height 0.0 0.1 0.3 -0.3 0.1 0.5
Chronic bronchitis/emphysema (father) 0.4 0.5 0.6 0.7 0.6 -0.8
High blood pressure (mother) 5.0 7.0 10.3 2.8 3.2 -1.7
Body mass index (BMI) 0.7 3.1 6.0 -1.7 -2.5 0.6
Impedance of leg (left) 5.6 27.1 38.1 5.2 6.2 -4.0
Leg predicted mass (left) 2.5 13.4 21.0 -3.9 -4.6 2.0
Trunk fat mass 0.5 2.1 4.1 -1.4 -2.0 0.1
Waist circumference 0.2 0.6 1.2 -0.6 -1.1 -0.5
Number of incorrect matches in round 0.2 0.3 0.9 0.3 0.9 0.1
Past tobacco smoking 5.2 9.6 15.2 -2.3 -2.9 3.9
Alcohol usually taken with meals 0.2 0.3 0.4 -0.4 -0.4 0.6
Nervous feelings 6.4 11.9 17.1 3.5 4.1 -2.5
Frequency of tenseness / restlessness in last 2 weeks 3.7 5.8 10.4 2.0 3.2 -1.8
Hearing difficulty/problems with background noise 0.2 0.4 0.9 0.2 1.0 -0.4
Hair/balding pattern: Pattern 2 1.1 1.3 2.0 -1.3 -1.4 0.7
Had menopause 0.8 1.0 1.6 0.9 1.3 -0.6
Had other major operations 0.0 0.0 0.0 -0.1 -0.0 0.2
Forced vital capacity (FVC) 2.3 8.8 10.0 2.8 3.2 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 1.7 -1.2 -1.3 0.9
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 2.4 1.1 1.6 -1.3
Qualifications: None of the above 1.4 3.0 3.7 1.4 1.8 -1.9
Financial difficulties in last 2 years 4.4 6.0 7.7 2.0 2.5 -2.8
Mouth/teeth dental problems 0.3 0.4 1.2 1.1 0.3 0.2
Heart attack 5.6 7.2 8.9 3.0 2.9 -2.0
Allergy 0.3 0.7 0.9 0.9 1.0 -0.7
Pain all over the body in last month 0.1 0.1 0.1 -0.4 0.3 -0.3
Diabetes (self-reported) 0.1 0.1 0.3 -0.0 -0.2 -0.6
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 2.2 -1.4 -1.4 1.5
Medication: Ramipril 1.3 1.6 2.9 1.2 1.7 -0.7
Medication: Simvastatin 0.0 0.1 0.1 -0.1 0.4 -0.1
Fluid intelligence score 1.1 2.2 3.7 -1.1 -1.9 1.3
Illnesses of siblings 1.2 1.7 2.8 -1.1 -1.7 1.1
Neuroticism score 2.3 4.7 7.2 2.1 2.7 -1.6
Weight 0.8 4.1 7.3 -2.2 -2.7 0.5
Impedance of arm (right) 0.5 2.5 3.7 1.8 1.9 -0.8
Arm fat percentage (right) 0.5 2.0 4.1 -1.3 -2.0 0.5
Trunk fat-free mass 1.0 6.0 8.9 -2.8 -3.0 1.1
Hip circumference 0.7 2.9 5.1 -1.9 -2.3 0.3
Time employed in main current job 4.1 4.7 7.0 -1.6 -2.1 2.6
Alcohol intake versus 10 years previously 3.0 4.5 6.8 1.9 1.8 -2.6
Father’s age at death 0.1 0.1 0.2 -0.2 -0.4 0.2
Worrier / anxious feelings 0.6 1.2 2.9 0.8 1.7 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.1 0.4 0.1 -0.3
Falls in the last year 2.0 2.7 4.6 2.1 1.6 -1.1
Hair/balding pattern: Pattern 3 0.9 1.3 2.8 0.6 1.7 -1.0
Number of live births 2.1 2.9 4.2 2.1 1.9 -1.0
Forced expiratory volume in 1-second (FEV1) 2.5 8.3 8.6 2.8 2.9 -2.9
Pulse rate 0.3 0.4 0.9 1.0 0.6 0.0
Happiness 0.1 0.1 0.3 0.0 0.2 -0.6
Noisy workplace 0.4 0.4 0.7 0.2 0.9 -0.8
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 -0.0 -0.4 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.5 0.7 0.6 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.5 1.2 -0.3 0.3 -1.1
Asthma 0.1 0.1 0.3 0.5 -0.1 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 3.7 1.9 1.0 -1.2
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.4 0.2 0.5
Depression (self-reported) 0.1 0.1 0.1 -0.4 0.2 0.1
Medication: Lansoprazole 0.3 0.3 0.8 -0.9 0.2 0.3
Prospective memory result 0.1 0.1 0.3 -0.6 -0.1 0.2
Lung cancer (father) 3.3 3.9 5.5 -1.8 -2.3 1.7
Illnesses of mother 3.2 3.9 5.2 -2.0 -2.3 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.8 6.5 2.5 2.4 -2.3
Pulse wave Arterial Stiffness index 0.1 0.2 0.3 0.0 0.4 0.6
Impedance of arm (left) 0.6 3.0 4.5 1.9 2.1 -1.0
Arm fat mass (right) 0.7 3.0 5.7 -1.7 -2.4 0.6
Trunk predicted mass 1.1 6.3 9.4 -2.9 -3.1 1.1
Standing height 0.1 1.1 2.2 -1.5 -1.0 -0.2
Length of working week for main job 1.8 2.0 2.8 1.2 1.3 -1.7
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.6 -0.5 -0.2
Breastfed as a baby 0.1 0.1 0.4 -0.0 0.6 0.3
Tense / ‘highly strung’ 8.5 14.0 18.0 4.2 4.0 -2.8
Seen doctor (GP) for nerves, anxiety, tension or depression 6.6 10.1 11.3 3.3 3.4 -2.8
Hair/balding pattern: Pattern 4 1.5 3.7 4.7 -1.5 -2.2 2.1
Birth weight of first child 3.9 7.2 9.2 -2.6 -3.0 2.4
Peak expiratory flow (PEF) 1.0 2.3 3.9 1.4 1.1 -2.0
Pulse wave reflection index 2.9 3.6 4.6 -2.1 -2.1 1.3
Ever highly irritable/argumentative for 2 days 1.8 2.2 3.8 0.9 1.9 -1.3
Loud music exposure frequency 0.5 0.5 0.9 0.5 0.6 -1.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.7 -0.8 -0.5 0.8
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 2.4 -1.5 -1.1 0.8
Blood clot in the leg (DVT) 0.1 0.1 0.3 0.5 -0.2 0.2
Medication: Paracetamol 3.7 6.1 6.8 2.5 2.6 -2.2
Headache pain in last month 0.2 0.4 0.5 -0.7 -0.6 0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.4 0.3 -0.7 -0.6
Glaucoma (self-reported) 3.5 4.1 5.5 2.4 1.9 -1.7
Gout (self-reported) 0.0 0.0 0.1 -0.2 0.2 0.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.5 -0.1 0.2
Medication: Amlodipine 0.5 0.7 1.7 0.7 1.3 0.0
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.0 -0.1 -0.1 -0.0
Birth weight 18.8 40.9 46.2 -6.7 -6.8 5.7
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 -0.8 -0.7 0.2
High blood pressure (siblings) 1.2 1.7 3.6 0.9 1.9 -0.9
Forced vital capacity (FVC), Best measure 1.8 6.5 6.7 2.6 2.6 -2.5
Body fat percentage 0.1 0.3 0.6 -0.1 -0.5 -0.8
Leg fat percentage (right) 0.4 1.3 2.8 0.9 0.5 -1.7
Arm fat-free mass (right) 0.7 3.8 6.1 -2.3 -2.5 0.6
Exposure to tobacco smoke outside home 0.9 1.3 2.9 0.7 0.6 -1.7
Comparative body size at age 10 0.4 1.1 2.8 0.6 0.3 -1.7
Number of full brothers 0.9 1.1 1.5 1.0 1.2 -1.0
Worry too long after embarrassment 6.0 10.0 13.3 2.5 3.7 -3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 3.3 0.8 1.8 -0.7
Wheeze or whistling in the chest in last year 2.6 4.6 6.4 -1.5 -2.5 2.2
Number of children fathered 0.1 0.1 0.2 0.0 0.2 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.2 -0.3 1.1 -0.6
Age at first live birth 8.3 14.8 15.7 -3.6 -3.9 4.0
Pulse wave peak to peak time 0.2 0.2 0.4 -0.3 -0.6 -0.5
Health satisfaction 0.8 1.1 1.2 1.0 1.0 -1.1
Shortness of breath walking on level ground 1.6 1.9 2.6 -1.1 -1.4 1.6
Qualifications: College or University degree 0.3 1.0 2.1 1.4 0.9 -0.5
Eye problems/disorders: None of the above 0.5 0.6 1.0 -0.3 -1.0 0.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 -0.8 -0.5 -0.3
Emphysema/chronic bronchitis 0.3 0.3 0.9 -0.2 0.3 -0.9
Medication for pain relief, constipation, heartburn 1.0 1.8 2.3 -1.5 -1.5 0.9
Neck or shoulder pain in last month 7.2 10.3 13.5 2.9 3.7 -2.9
Medication: Blood pressure 0.2 0.4 0.8 -0.3 0.9 0.5
Angina (self-reported) 7.2 9.5 11.4 3.2 3.4 -2.6
Migraine (self-reported) 3.7 4.5 7.6 -1.8 -2.8 1.6
Medication: Ibuprofen 2.0 2.5 4.4 2.1 1.0 -1.4
Medication: Allopurinol 1.6 2.2 3.2 1.1 1.8 -1.5
Medication: Omeprazole 0.0 0.0 0.1 0.0 0.3 0.1
Medication: Seretide 50 evohaler 2.5 2.9 4.6 -2.1 -1.6 1.1
Mean time to correctly identify matches 0.2 0.3 0.8 0.4 0.9 -0.1
Heart disease (mother) 0.7 0.8 1.6 0.6 1.2 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.0 0.3 0.9 -1.0
Whole body fat mass 0.4 1.5 3.1 -1.2 -1.7 -0.2
Leg fat mass (right) 0.2 0.8 1.6 -0.6 -1.3 -0.6
Arm predicted mass (right) 0.7 3.6 5.6 -2.2 -2.4 0.5
Pulse rate, automated reading 0.5 1.7 2.6 1.6 1.6 -0.2
Alcohol intake frequency. 0.9 2.0 2.4 1.2 1.4 -1.6
Comparative height size at age 10 0.7 4.0 8.5 -2.9 -1.8 0.3
Number of full sisters 0.3 0.4 1.0 0.2 0.2 -1.0
Suffer from ‘nerves’ 2.5 4.0 6.5 2.0 2.5 -1.3
Overall health rating 0.8 1.7 2.0 1.1 1.4 -1.4
Chest pain or discomfort 1.0 1.4 2.7 0.6 1.6 -1.1
Had major operations 2.5 2.9 4.8 1.4 1.5 -2.2
Age at last live birth 4.4 6.4 7.4 -2.2 -2.6 2.7
Family relationship satisfaction 2.5 3.1 4.4 0.9 2.0 -2.1
Leg pain on walking 0.4 0.5 1.4 1.2 0.4 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.5 0.4 0.6 -0.7
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.1 -0.5 0.3
Illness, injury, bereavement, stress in last 2 years 5.7 6.9 8.9 -2.3 -3.0 2.5
Medication: Aspirin 0.2 0.2 0.4 -0.1 0.6 0.5
Supplements: Vitamin C 0.2 0.3 0.6 0.1 -0.8 0.4
Knee pain experienced in last month 0.1 0.2 0.4 0.6 -0.4 -0.1
Hypertension (Self-reported) 6.0 16.7 29.9 3.2 5.5 -3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.2 0.3 1.1 -0.6
Illnesses of father: Heart disease 2.0 2.8 4.9 1.5 2.2 -1.1
Illnesses of siblings: Diabetes 2.7 3.4 4.7 -1.6 -2.2 1.6
Smoking status: Previous 5.2 7.7 10.2 2.2 2.8 -3.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 -0.1 -0.7 0.1
Whole body fat-free mass 1.7 9.6 14.6 -3.4 -3.8 1.6
Leg fat-free mass (right) 3.0 15.9 23.9 -4.2 -4.9 2.4
Arm fat percentage (left) 0.4 1.5 3.4 -1.0 -1.8 0.3
Average weekly red wine intake 0.1 0.1 0.2 0.3 0.0 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.5 -0.7 -0.7 0.7
Mood swings 0.5 0.9 1.7 -0.7 -0.6 1.3
Loneliness, isolation 0.0 0.0 0.0 -0.1 -0.1 0.0
Long-standing illness, disability or infirmity 1.4 2.1 2.9 1.3 1.7 -1.3
Ever had bowel cancer screening 0.2 0.2 0.6 -0.8 0.2 -0.0
Diabetes diagnosed by doctor 0.1 0.2 0.5 0.0 -0.1 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 0.7 0.8 0.7 -0.8
Friendships satisfaction 1.0 1.3 2.0 -1.4 -1.1 0.7
Qualifications: nursing, teaching 0.2 0.3 0.4 0.6 0.4 -0.4
Commuting to job workplace: Walk 0.9 0.9 1.9 0.8 1.4 -0.5
Eye problems/disorders: Cataract 0.3 0.3 0.5 -0.7 0.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 3.2 -1.5 -1.7 1.8
Medication for cholesterol 2.4 3.7 6.7 -1.6 -2.6 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 2.6 1.6 1.2 -1.4
Back pain experienced in last month 3.3 4.8 5.7 2.4 2.2 -2.0
Mineral and other dietary supplements 0.5 0.6 1.5 -1.2 0.1 0.6
Breast cancer (self-reported) 1.8 2.1 3.0 -1.0 -1.6 1.7
Asthma (self-reported) 0.1 0.2 0.4 0.7 -0.1 -0.3
Osteoporosis (self-reported) 1.0 1.3 1.9 0.9 1.4 -1.1
Osteoarthritis (self-reported) 1.9 2.5 3.3 1.5 1.8 -1.4
Medication: Aspirin 0.4 0.5 1.5 0.4 1.2 0.0
Medication: Gliclazide 0.0 0.0 0.0 0.1 -0.0 0.2
Illnesses of father: None of the above (group 1) 4.7 5.8 7.9 -2.3 -2.8 2.0
Smoking status: Current 2.4 3.8 6.9 1.5 1.4 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.2 13.1 14.2 3.8 3.7 -3.4
Whole body water mass 1.6 9.1 13.9 -3.4 -3.7 1.5
Leg predicted mass (right) 3.0 16.2 24.3 -4.3 -4.9 2.5
Arm fat mass (left) 0.6 2.5 5.1 -1.5 -2.2 0.4
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 -0.2 0.6 0.3
Average weekly champagne plus white wine intake 2.9 4.0 5.7 -1.7 -2.4 1.9
Miserableness 0.2 0.4 0.6 -0.2 0.7 -0.8
Guilty feelings 0.0 0.1 0.1 -0.3 0.3 -0.2
Wears glasses or contact lenses 0.0 0.1 0.1 -0.3 0.2 0.2
Ever taken oral contraceptive pill 0.4 0.5 0.9 -0.7 -0.9 -0.2
Hearing aid user 0.3 0.3 0.5 0.3 0.7 -0.6
Mother’s age at death 0.0 0.0 0.1 -0.2 -0.2 0.1
Financial situation satisfaction 0.7 0.8 1.9 -1.4 -0.7 0.1
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.7 -0.8 -0.0 -0.1
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.4 0.8 -0.6
Eye problems/disorders: Glaucoma 2.9 3.4 4.9 2.2 1.6 -1.6
Medication: Blood pressure 7.7 14.6 22.1 3.6 4.7 -3.0
Pain type(s) experienced in last month: Hip pain 5.5 6.9 7.4 2.7 2.5 -2.7
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.6 0.8 -0.2 -0.0
High cholesterol (Self-reported) 0.1 0.3 0.7 -0.0 0.8 -0.3
Medication: Bendroflumethiazide 2.0 3.0 5.3 1.4 2.3 -1.4
Medication: Paracetamol 2.9 4.5 5.4 2.2 2.3 -1.9
Medication: Lisinopril 1.1 1.4 3.4 0.0 1.8 -0.9
Medication: Atorvastatin 2.3 2.8 4.8 1.3 2.2 -1.3
Illnesses of father: High blood pressure 3.2 3.9 6.8 1.3 2.6 -1.8
Alcohol drinker status: Never 0.2 0.2 0.6 0.1 -0.2 0.8
Ever smoked 4.1 7.2 12.0 2.0 2.4 -3.5
Basal metabolic rate 1.6 8.6 13.6 -3.2 -3.7 1.4
Leg fat percentage (left) 0.1 0.4 1.2 0.1 0.0 -1.1
Arm fat-free mass (left) 1.0 5.1 8.0 -2.5 -2.8 0.9
Number of operations (self-reported) 0.1 0.2 0.5 -0.7 -0.3 0.1
Average weekly beer plus cider intake 1.9 2.7 3.6 -1.9 -1.6 1.4
Irritability 1.7 2.8 3.6 1.9 1.6 -1.5
Risk taking 2.1 3.1 3.4 1.8 1.6 -1.9
Ever had prostate specific antigen (PSA) test 2.2 2.6 4.1 -1.2 -1.5 2.0
Fractured/broken bones in last 5 years 5.2 6.7 8.1 2.4 2.8 -2.5
Age started oral contraceptive pill 0.2 0.2 0.3 -0.6 0.5 -0.4
Diastolic blood pressure, automated reading 7.4 23.0 30.8 5.2 5.5 -3.3
Ever depressed for a whole week 1.2 1.4 2.9 0.4 1.7 -1.1
Unable to work because of sickness or disability 1.0 1.3 2.4 0.9 1.5 -0.9
Commuting to job workplace: Cycle 0.8 0.9 1.5 0.7 1.2 -0.9
Myopia 0.2 0.3 0.6 0.3 -0.4 0.8
Vascular/heart problems diagnosed by doctor 7.7 20.9 36.2 -3.7 -6.0 3.6
Cholesterol lowering medication 2.8 4.1 5.3 2.0 2.3 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 -0.2 0.1 0.3
Pain experienced in last month 0.9 1.5 2.6 -1.6 -1.1 0.7
Supplements: Calcium 2.6 2.9 3.9 2.0 1.5 -1.6
Basal cell carcinoma (self-reported) 0.8 0.9 1.2 -0.8 -0.9 1.1
Heart attack/myocardial infarction (self-reported) 4.9 6.3 8.2 2.9 2.7 -1.8
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 0.0 -0.4 0.6
Heart disease (siblings) 2.2 2.7 4.8 1.3 2.2 -1.2
Alcohol drinker status: Previous 0.0 0.0 0.1 -0.3 0.2 -0.1
Pack years of smoking 5.1 7.5 11.4 1.8 2.8 -3.4
Impedance of whole body 2.4 12.3 18.2 3.5 4.3 -2.5
Leg fat mass (left) 0.3 1.1 2.2 -1.0 -1.5 -0.3
Arm predicted mass (left) 0.9 4.5 7.4 -2.4 -2.7 0.7