[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor :

chr17:6,754,828-8,484,683

Best TWAS P=2.68e-09 · Best GWAS P=3.44e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Colon Transverse LSMD1 0.28 0.12 lasso 5 0.19 3.3e-09 -5.9 -5.5 3.9e-08 0.89 0.01 0.99 FALSE
2 METSIM Adipose SENP3 0.06 0.03 lasso 3 0.02 4.9e-04 -5.3 6.0 2.7e-09 -0.11 0.10 0.80 TRUE
3 NTR Blood TNFSF12 0.06 0.07 bslmm 462 0.07 9.4e-23 -5.2 -5.2 1.9e-07 0.11 0.22 0.77 FALSE
4 ROSMAP Brain Pre-frontal Cortex KDM6B 0.07 0.05 lasso 4 0.04 2.7e-06 -5.9 5.3 1.2e-07 -0.95 0.00 1.00 FALSE
5 The Cancer Genome Atlas Colon Adenocarcinoma CYB5D1 0.14 0.12 lasso 1 0.10 1.7e-06 -5.9 5.9 3.4e-09 -1.00 0.00 1.00 TRUE
6 The Cancer Genome Atlas Colon Adenocarcinoma TNFSF12-TNFSF13 0.07 0.05 lasso 3 0.02 1.9e-02 -5.3 -5.3 1.0e-07 0.11 0.00 0.93 FALSE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TNFSF12 0.04 0.01 enet 9 0.01 4.3e-02 -5.3 5.8 8.4e-09 -0.08 0.00 0.88 FALSE
8 The Cancer Genome Atlas Brain Lower Grade Glioma SLC2A4 0.09 0.04 lasso 4 0.06 7.2e-08 4.8 -5.3 8.9e-08 0.05 0.00 0.99 TRUE
9 The Cancer Genome Atlas Prostate Adenocarcinoma SHBG 0.04 0.01 blup 60 0.03 5.4e-04 -4.2 -5.6 2.7e-08 0.10 0.01 0.46 FALSE