Best TWAS P=2.68e-09 · Best GWAS P=3.44e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | LSMD1 | 0.28 | 0.12 | lasso | 5 | 0.19 | 3.3e-09 | -5.9 | -5.5 | 3.9e-08 | 0.89 | 0.01 | 0.99 | FALSE |
| 2 | METSIM | Adipose | SENP3 | 0.06 | 0.03 | lasso | 3 | 0.02 | 4.9e-04 | -5.3 | 6.0 | 2.7e-09 | -0.11 | 0.10 | 0.80 | TRUE |
| 3 | NTR | Blood | TNFSF12 | 0.06 | 0.07 | bslmm | 462 | 0.07 | 9.4e-23 | -5.2 | -5.2 | 1.9e-07 | 0.11 | 0.22 | 0.77 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KDM6B | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.7e-06 | -5.9 | 5.3 | 1.2e-07 | -0.95 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYB5D1 | 0.14 | 0.12 | lasso | 1 | 0.10 | 1.7e-06 | -5.9 | 5.9 | 3.4e-09 | -1.00 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | TNFSF12-TNFSF13 | 0.07 | 0.05 | lasso | 3 | 0.02 | 1.9e-02 | -5.3 | -5.3 | 1.0e-07 | 0.11 | 0.00 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFSF12 | 0.04 | 0.01 | enet | 9 | 0.01 | 4.3e-02 | -5.3 | 5.8 | 8.4e-09 | -0.08 | 0.00 | 0.88 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC2A4 | 0.09 | 0.04 | lasso | 4 | 0.06 | 7.2e-08 | 4.8 | -5.3 | 8.9e-08 | 0.05 | 0.00 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SHBG | 0.04 | 0.01 | blup | 60 | 0.03 | 5.4e-04 | -4.2 | -5.6 | 2.7e-08 | 0.10 | 0.01 | 0.46 | FALSE |