Hub : Genes

HOXB9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0646 0.0239 1.3e-05 0.032 0.031 0.048 0.037 0.043 1.2e-05 1.5e-05 9.9e-08 2.3e-06 4.2e-07
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0464 0.0273 7.2e-03 0.001 0.003 0.007 NA 0.001 2.5e-01 1.3e-01 4.4e-02 NA 2.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.6 3.0 1.7 0.4
Bipolar Disorder or Schizophrenia 1.1 2.6 4.8 2.2 -0.7
Depressed Affect (Nagel 2018) 1.0 2.1 3.6 -0.8 -1.9
Depression (Nagel 2018) 0.8 1.1 2.2 0.2 -1.5
Intelligence (Savage-Jansen 2018) 1.8 5.5 5.5 -2.3 2.3
Neuroticism (Nagel 2018) 0.1 0.2 0.4 0.2 -0.6
Schizophrenia (2018) 0.9 1.9 1.9 1.4 -1.4
Schizophrenia vs Biploar Disorder 3.2 4.2 7.5 1.0 -2.7
Worry (Nagel 2018) 0.2 0.5 0.5 0.7 0.7
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 -0.3 -0.8
Alzheimer’s Disease (in father) 2.5 2.7 4.6 -2.1 -0.8
Alzheimer’s Disease (including proxy) 0.8 1.2 2.1 -0.6 -1.4
Crohns Disease (2017) 0.3 0.7 1.0 1.0 -0.6
Irritable Bowel Disease (IBD) 0.2 0.6 0.8 0.6 -0.9
Ulcerative Colitis (UC) 0.4 0.8 1.6 0.3 -1.3
Major Depression (MDD) 1.3 1.6 2.2 -1.0 -1.5
Reaction Time 0.4 0.8 1.5 0.3 -1.2
Verbal and Numeric Reasoning (VNR) 1.7 4.0 5.8 -2.4 1.5
Breast Cancer 0.3 0.8 1.6 -0.3 1.3
Ovarian Cancer 7.7 10.2 10.5 3.2 -3.1
Prostate Cancer 0.2 0.3 0.6 -0.8 0.2
Age at First Birth 0.5 0.8 1.0 -0.8 1.0
Bipolar Disorder (2011) 0.1 0.1 0.2 0.5 0.0
Body Mass Index (BMI) (2010) 1.5 2.0 3.9 2.0 -0.3
Coronary Artery Disease (CAD) 0.8 1.0 1.7 1.3 -0.5
Crohns Disease (2012) 2.6 4.2 4.5 2.0 -2.1
Mean Putamen Volume 0.1 0.1 0.2 0.1 -0.4
Fasting Glucose 1.6 1.9 2.6 -1.1 1.6
HbA1C 0.4 0.5 0.9 -0.2 1.0
HDL Cholesterol 0.4 0.7 1.3 0.2 -1.1
LDL Cholesterol 1.9 3.0 5.8 2.4 -0.4
Lupus 0.0 0.0 0.1 -0.2 0.1
Neuroticism (2016) 0.4 0.6 0.7 -0.7 0.8
Primary Biliary Cirrhosis 0.7 1.1 1.7 0.6 -1.3
Rheumatoid Arthritis 2.7 3.7 7.3 -2.7 0.4
Schizophrenia (2014) 1.2 2.7 3.4 1.4 -1.8
Triglycerides 1.2 1.9 2.5 -1.6 1.1
Type 2 Diabetes (T2D) (2012) 3.4 3.9 7.1 -0.9 2.7
Ulcerative Colitis 0.5 0.7 1.2 0.4 -1.1
Blood Eosinophil Count 0.1 0.8 1.1 -0.7 1.1
Blood Platelet Count 0.9 10.5 10.8 -3.3 3.2
Blood Red Count 3.1 29.6 34.3 5.9 -5.0
Blood White Count 0.5 3.7 5.9 -2.4 1.2
Heel T-Score 0.0 0.0 0.1 -0.2 0.2
BMI 2.6 15.0 29.4 5.4 -0.7
Height 1.8 34.1 67.6 -8.2 0.8
Waist Hip Ratio (WHR) 0.5 2.0 3.8 1.9 -0.6
Systolic Blood Pressure 6.3 31.5 62.3 -0.9 7.9
Smoking Status 0.1 0.3 0.5 -0.4 -0.7
Allergy or Eczema 0.8 2.1 3.3 1.0 -1.8
Cardiovascular Disease 3.9 12.7 22.2 1.8 4.7
Hypothyroidism (self reported) 0.3 0.7 1.4 0.2 -1.2
Respiratory disease 0.9 2.0 4.0 2.0 0.0
Type 2 Diabetes (T2D) (2018) 0.2 0.5 0.5 -0.7 -0.7
Lung FEV1/FVC ratio 2.2 11.0 18.1 -4.3 2.0
Lung FVC 2.2 11.4 22.3 4.7 -0.7
Neuroticism 0.2 0.4 0.8 -0.3 -0.9
Chronotype (morning person) 0.3 0.7 0.9 0.7 1.0
Hair Pigment 0.4 11.8 19.4 -2.0 -4.4
Tanning 0.0 0.2 0.3 0.6 0.3
Hand grip strength (left) 4.9 12.9 24.9 5.0 -0.9
Number of treatments/medications taken 0.3 0.5 1.0 0.2 1.0
Average weekly spirits intake 4.0 5.0 6.2 2.5 -1.9
Sensitivity / hurt feelings 0.0 0.0 0.0 0.0 0.1
Frequency of depressed mood in last 2 weeks 1.4 2.0 2.9 1.0 -1.7
Hearing difficulty/problems: Yes 3.4 5.3 5.9 2.4 -2.2
Relative age of first facial hair 0.3 0.6 1.2 -0.1 -1.1
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 3.3 -0.2 -1.8
Ever used hormone-replacement therapy (HRT) 1.9 2.4 4.6 -2.1 0.5
Ever had hysterectomy (womb removed) 1.6 1.8 3.3 -1.8 -0.4
Systolic blood pressure, automated reading 6.8 19.6 39.2 0.2 6.3
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 2.5 0.9 -1.6
Angina 3.3 4.4 5.8 -1.7 2.4
Medication for hormone replacement therapy 3.5 3.9 7.1 -2.7 -0.8
Vitamin and mineral supplements 0.1 0.1 0.1 0.3 -0.2
Supplements: Zinc 0.8 0.9 1.1 0.8 -1.0
Medication: Co-codamol 0.3 0.3 0.4 -0.5 -0.6
Medication: Metformin 0.9 1.2 2.0 -1.4 0.7
Diabetes (father) 0.7 0.9 1.3 0.7 -1.2
Diabetes (mother) 0.1 0.1 0.2 0.1 0.4
Severe depression (siblings) 0.6 0.7 1.2 -0.3 1.1
Pack years adult smoking proportion 0.9 1.4 2.8 1.7 0.1
Impedance of leg (right) 1.4 7.0 13.7 -3.7 0.6
Leg fat-free mass (left) 0.5 2.4 4.4 2.1 -0.7
Trunk fat percentage 0.4 1.7 2.2 1.1 -1.5
Hand grip strength (right) 4.2 11.5 21.3 4.6 -1.3
Townsend deprivation index at recruitment 0.8 1.2 1.8 0.8 -1.3
Current tobacco smoking 0.0 0.1 0.1 0.1 -0.3
Average weekly fortified wine intake 2.3 2.6 5.3 -0.2 2.3
Maternal smoking around birth 1.0 1.5 2.2 -1.5 -0.9
Fed-up feelings 1.2 2.2 4.2 0.5 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.0 1.0 -0.9
Relative age voice broke 0.2 0.4 0.7 0.9 -0.0
Taking other prescription medications 0.0 0.0 0.0 -0.1 -0.2
Age when periods started (menarche) 0.5 1.2 1.6 -1.3 0.9
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 2.6 -1.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 0.2 0.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.4 1.2 0.3
Qualifications: CSEs or equivalent 1.1 1.4 2.9 1.7 -0.2
Serious illness, injury or assault to yourself 1.1 1.3 2.2 0.6 -1.5
High blood pressure 5.1 14.2 28.3 0.4 5.3
Hayfever, allergic rhinitis or eczema 1.1 2.4 2.7 1.4 -1.6
Multivitamins +/- minerals 0.2 0.2 0.2 -0.4 0.5
Stomach or abdominal pain in last month 0.5 0.6 0.8 -0.6 -0.9
Supplements: Glucosamine 0.7 0.9 1.9 -0.2 1.4
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 -0.2 0.2
Medication: Atenolol 1.9 2.4 4.2 -0.8 2.0
Medication: Levothyroxine sodium 1.0 1.8 2.6 1.0 -1.6
Sitting height 2.6 18.6 33.4 -5.8 1.9
Chronic bronchitis/emphysema (father) 1.2 1.4 1.5 -1.2 -1.2
High blood pressure (mother) 1.3 1.8 3.4 0.4 1.9
Body mass index (BMI) 2.8 12.0 22.5 4.7 -1.2
Impedance of leg (left) 2.0 9.7 19.1 -4.4 0.5
Leg predicted mass (left) 0.5 2.6 4.6 2.1 -0.8
Trunk fat mass 0.3 1.2 1.4 1.2 -1.0
Waist circumference 3.2 11.6 21.5 4.6 -1.3
Number of incorrect matches in round 0.8 1.4 1.4 -1.1 1.2
Past tobacco smoking 0.1 0.2 0.2 0.4 0.4
Alcohol usually taken with meals 4.1 6.6 10.8 -1.6 3.3
Nervous feelings 1.1 2.0 3.4 0.8 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.2 0.5 -0.3
Hearing difficulty/problems with background noise 1.4 2.2 2.9 1.7 -1.2
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 -0.1 -0.2
Had menopause 0.8 1.0 1.8 -1.4 0.3
Had other major operations 1.1 1.3 2.6 -0.0 -1.6
Forced vital capacity (FVC) 0.1 0.2 0.3 0.6 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.1 -0.1 0.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.7 -0.9 -0.7
Qualifications: None of the above 0.1 0.1 0.2 -0.2 0.5
Financial difficulties in last 2 years 1.4 1.8 2.1 1.3 -1.4
Mouth/teeth dental problems 2.6 4.1 6.4 -1.3 2.5
Heart attack 0.6 0.7 1.0 -0.7 1.0
Allergy 1.3 3.1 4.0 -2.0 1.5
Pain all over the body in last month 2.4 2.5 5.0 0.1 -2.2
Diabetes (self-reported) 0.5 0.8 1.5 -1.2 -0.3
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.7 1.9 -0.7
Medication: Ramipril 1.2 1.5 2.5 -0.7 1.6
Medication: Simvastatin 1.6 2.4 3.8 1.0 1.9
Fluid intelligence score 1.0 2.1 3.8 -1.9 0.6
Illnesses of siblings 0.7 1.0 1.8 0.4 -1.4
Neuroticism score 0.4 0.7 1.4 1.2 -0.3
Weight 0.6 2.8 5.2 2.3 -0.6
Impedance of arm (right) 1.5 6.9 13.6 -3.7 0.4
Arm fat percentage (right) 1.9 7.3 12.1 3.5 -1.6
Trunk fat-free mass 0.1 0.4 0.7 0.8 0.3
Hip circumference 1.3 5.6 9.4 3.1 -1.4
Time employed in main current job 0.1 0.1 0.1 -0.2 -0.3
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.1 0.6
Father’s age at death 1.2 1.6 2.8 -1.7 0.7
Worrier / anxious feelings 0.6 1.1 1.2 1.0 1.1
Frequency of tiredness / lethargy in last 2 weeks 3.1 5.1 7.3 1.7 -2.7
Falls in the last year 0.0 0.0 0.1 -0.1 -0.3
Hair/balding pattern: Pattern 3 3.4 5.0 5.8 2.1 2.4
Number of live births 0.4 0.5 1.1 0.0 -1.0
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 0.1 0.4
Pulse rate 0.4 0.7 1.5 0.1 -1.2
Happiness 1.6 1.9 2.3 1.2 -1.5
Noisy workplace 0.6 0.7 0.8 0.7 -0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.2 -0.5 1.1
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.3 -1.5 0.7
Mouth/teeth dental problems: Dentures 6.5 10.9 19.9 1.4 -4.5
Asthma 0.6 1.3 1.8 1.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.3 -0.3 -0.6
Medication: Cholesterol lowering 0.3 0.4 0.6 0.8 0.5
Depression (self-reported) 2.6 3.2 3.7 -1.6 1.9
Medication: Lansoprazole 1.3 1.5 1.6 -1.2 1.2
Prospective memory result 0.3 0.4 0.7 0.3 0.9
Lung cancer (father) 1.0 1.1 2.0 -1.4 -0.5
Illnesses of mother 0.2 0.3 0.5 -0.1 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 0.6 -0.1
Pulse wave Arterial Stiffness index 2.2 2.6 3.6 -1.9 1.2
Impedance of arm (left) 1.3 6.0 12.0 -3.5 -0.3
Arm fat mass (right) 1.6 6.6 11.2 3.3 -1.4
Trunk predicted mass 0.1 0.4 0.7 0.8 0.3
Standing height 1.3 13.1 25.5 -5.0 0.8
Length of working week for main job 0.9 1.0 1.6 0.7 -1.3
Exposure to tobacco smoke at home 4.2 4.7 7.3 -1.5 -2.7
Breastfed as a baby 0.6 0.8 1.3 -1.1 0.6
Tense / ‘highly strung’ 0.1 0.2 0.3 0.6 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.8 -0.9 -0.5
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 -0.6 -0.1
Birth weight of first child 0.5 0.8 1.5 1.2 0.3
Peak expiratory flow (PEF) 4.0 9.4 15.1 -3.9 1.9
Pulse wave reflection index 0.0 0.1 0.1 -0.1 0.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.6 0.3 -0.8
Loud music exposure frequency 0.0 0.0 0.0 -0.1 -0.2
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.4 -0.4 1.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.3 0.6 -0.5
Blood clot in the leg (DVT) 2.5 3.2 6.3 0.4 -2.5
Medication: Paracetamol 0.2 0.3 0.6 -0.1 -0.8
Headache pain in last month 1.1 1.9 3.3 0.8 -1.8
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 4.1 0.4 -2.0
Glaucoma (self-reported) 0.6 0.7 1.0 1.0 -0.7
Gout (self-reported) 0.9 1.2 1.3 -1.1 1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.5 0.4 -1.2
Medication: Amlodipine 3.5 4.9 9.8 -0.3 3.1
Medication: Ventolin 100micrograms inhaler 3.3 4.3 6.7 2.6 -1.3
Birth weight 0.2 0.5 0.7 0.8 0.6
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.2 -0.2 -1.5
High blood pressure (siblings) 0.7 1.0 1.8 -0.5 1.3
Forced vital capacity (FVC), Best measure 0.1 0.5 0.9 1.0 0.0
Body fat percentage 0.7 2.7 4.0 2.0 -1.2
Leg fat percentage (right) 1.3 4.6 8.7 3.0 -0.7
Arm fat-free mass (right) 0.2 1.0 2.0 1.4 -0.1
Exposure to tobacco smoke outside home 6.0 8.1 11.4 2.2 -3.4
Comparative body size at age 10 1.8 5.1 8.9 3.0 1.1
Number of full brothers 1.6 2.0 3.8 -0.4 -1.9
Worry too long after embarrassment 2.7 4.6 6.5 2.6 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 0.7 -0.8 -0.8
Wheeze or whistling in the chest in last year 2.6 4.7 9.2 3.0 -0.3
Number of children fathered 0.4 0.4 0.5 0.6 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.0 -0.1 -1.4
Age at first live birth 0.6 1.0 2.0 -0.1 1.4
Pulse wave peak to peak time 2.2 2.6 3.0 1.7 -1.5
Health satisfaction 5.8 7.6 11.0 3.3 -2.0
Shortness of breath walking on level ground 0.6 0.8 1.2 0.6 -1.1
Qualifications: College or University degree 0.5 1.5 2.2 -1.5 1.0
Eye problems/disorders: None of the above 0.7 0.8 1.7 -1.3 0.1
Mouth/teeth dental problems: Loose teeth 1.5 1.8 2.0 -1.3 1.4
Emphysema/chronic bronchitis 0.3 0.3 0.6 -0.2 -0.8
Medication for pain relief, constipation, heartburn 0.0 0.0 0.0 -0.0 -0.2
Neck or shoulder pain in last month 0.2 0.3 0.6 0.2 -0.8
Medication: Blood pressure 3.5 6.1 11.8 -0.7 3.4
Angina (self-reported) 3.2 4.2 4.9 -1.9 2.2
Migraine (self-reported) 0.5 0.6 1.2 -0.3 -1.1
Medication: Ibuprofen 0.5 0.5 1.0 0.2 -1.0
Medication: Allopurinol 0.8 1.0 1.3 -0.8 1.2
Medication: Omeprazole 1.7 2.1 4.1 -0.1 2.0
Medication: Seretide 50 evohaler 1.0 1.1 1.9 -0.6 -1.4
Mean time to correctly identify matches 0.0 0.1 0.2 -0.4 -0.0
Heart disease (mother) 0.2 0.3 0.5 0.7 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.3 1.5 0.5
Whole body fat mass 0.6 2.3 3.9 2.0 -0.8
Leg fat mass (right) 1.2 4.8 9.5 3.1 -0.5
Arm predicted mass (right) 0.3 1.4 2.5 1.6 -0.6
Pulse rate, automated reading 0.7 2.2 2.6 1.6 1.4
Alcohol intake frequency. 0.5 1.1 2.1 1.4 -0.4
Comparative height size at age 10 0.5 2.8 5.2 -2.3 0.6
Number of full sisters 0.9 1.1 2.1 1.4 -0.2
Suffer from ‘nerves’ 0.7 1.1 1.1 -1.1 1.0
Overall health rating 4.4 9.4 12.2 3.5 -2.6
Chest pain or discomfort 1.6 2.2 3.7 0.9 -1.9
Had major operations 0.4 0.4 0.5 -0.7 -0.6
Age at last live birth 1.1 1.6 2.3 0.9 1.5
Family relationship satisfaction 2.0 2.5 3.2 1.4 -1.8
Leg pain on walking 0.4 0.4 0.9 0.9 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 3.6 1.9 -0.8
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 0.0 0.1
Illness, injury, bereavement, stress in last 2 years 2.1 2.6 3.1 -1.8 1.4
Medication: Aspirin 1.9 2.6 4.9 -0.5 2.2
Supplements: Vitamin C 0.3 0.4 0.7 0.2 0.9
Knee pain experienced in last month 1.0 1.5 1.8 1.1 -1.3
Hypertension (Self-reported) 4.0 11.1 22.1 0.4 4.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.0 0.9 1.0
Illnesses of father: Heart disease 0.5 0.7 0.7 0.8 0.8
Illnesses of siblings: Diabetes 2.7 3.3 4.0 -1.6 2.0
Smoking status: Previous 0.1 0.2 0.4 -0.0 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.0 -0.3 -1.0
Whole body fat-free mass 0.2 1.1 2.1 1.5 -0.2
Leg fat-free mass (right) 0.4 2.0 3.5 1.9 -0.7
Arm fat percentage (left) 2.0 8.1 13.0 3.6 -1.8
Average weekly red wine intake 0.2 0.4 0.4 0.6 0.6
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.2 0.0
Mood swings 0.3 0.5 0.7 -0.5 -0.8
Loneliness, isolation 0.3 0.4 0.4 0.6 -0.7
Long-standing illness, disability or infirmity 1.2 1.8 3.1 0.7 -1.8
Ever had bowel cancer screening 7.4 8.6 14.6 -3.8 1.6
Diabetes diagnosed by doctor 0.2 0.4 0.7 -0.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.8 -0.4 -1.3
Friendships satisfaction 1.0 1.3 1.8 0.9 -1.3
Qualifications: nursing, teaching 0.2 0.3 0.7 -0.8 -0.1
Commuting to job workplace: Walk 0.6 0.7 1.3 1.1 0.2
Eye problems/disorders: Cataract 0.3 0.4 0.5 0.7 0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 0.9 -0.5
Medication for cholesterol 0.9 1.4 2.6 0.4 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 -0.3 -0.6
Back pain experienced in last month 1.3 1.9 3.1 -0.8 -1.8
Mineral and other dietary supplements 0.7 0.9 1.3 -0.7 -1.1
Breast cancer (self-reported) 0.5 0.6 1.0 -0.4 1.0
Asthma (self-reported) 0.7 1.3 1.8 1.3 0.9
Osteoporosis (self-reported) 0.1 0.1 0.3 -0.5 -0.1
Osteoarthritis (self-reported) 0.6 0.7 1.0 1.0 0.6
Medication: Aspirin 1.5 1.9 2.9 -1.0 1.7
Medication: Gliclazide 1.1 1.3 2.6 -1.6 0.0
Illnesses of father: None of the above (group 1) 0.3 0.4 0.6 0.3 0.8
Smoking status: Current 0.0 0.0 0.1 0.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.7 1.6 -0.4
Whole body water mass 0.2 1.3 2.6 1.6 -0.3
Leg predicted mass (right) 0.4 2.1 3.7 1.9 -0.8
Arm fat mass (left) 1.7 6.9 11.3 3.4 -1.6
Number of self-reported non-cancer illnesses 1.1 1.8 2.2 1.2 1.5
Average weekly champagne plus white wine intake 1.2 1.7 3.1 -1.8 0.5
Miserableness 0.2 0.4 0.7 0.3 -0.9
Guilty feelings 0.8 1.2 2.3 1.5 0.4
Wears glasses or contact lenses 1.3 1.5 1.7 -1.1 1.3
Ever taken oral contraceptive pill 0.4 0.5 0.9 -1.0 0.1
Hearing aid user 0.2 0.2 0.3 0.3 -0.5
Mother’s age at death 0.3 0.3 0.6 -0.8 0.2
Financial situation satisfaction 6.0 7.4 8.9 2.4 -3.0
Tinnitus: Yes, now most or all of the time 2.9 3.4 3.7 1.9 -1.8
Commuting to job workplace: Public transport 0.5 0.6 1.1 0.2 -1.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.0 0.7 -1.0
Medication: Blood pressure 1.8 3.5 7.0 0.3 2.6
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 0.2 -1.2
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.5 0.5 0.7
High cholesterol (Self-reported) 2.0 3.5 5.7 2.4 1.2
Medication: Bendroflumethiazide 1.6 2.4 3.1 -1.3 1.8
Medication: Paracetamol 2.0 3.1 4.3 1.3 -2.1
Medication: Lisinopril 1.6 2.0 3.8 -0.5 1.9
Medication: Atorvastatin 0.6 0.8 1.4 1.2 0.4
Illnesses of father: High blood pressure 0.5 0.6 1.2 -0.1 1.1
Alcohol drinker status: Never 2.9 3.5 5.2 1.3 -2.3
Ever smoked 0.0 0.0 0.0 -0.2 0.1
Basal metabolic rate 0.3 1.8 3.4 1.9 -0.5
Leg fat percentage (left) 0.9 3.1 5.9 2.4 -0.6
Arm fat-free mass (left) 0.2 1.1 2.0 1.4 -0.3
Number of operations (self-reported) 1.0 1.5 2.8 -1.7 -0.5
Average weekly beer plus cider intake 0.3 0.4 0.7 -0.8 -0.3
Irritability 0.2 0.3 0.4 0.6 -0.4
Risk taking 2.4 3.5 6.2 -0.9 -2.5
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.1 -1.1 0.2
Fractured/broken bones in last 5 years 0.5 0.7 1.2 -0.4 -1.1
Age started oral contraceptive pill 0.8 0.9 1.3 1.1 0.8
Diastolic blood pressure, automated reading 3.1 9.6 11.3 3.4 2.8
Ever depressed for a whole week 0.6 0.7 1.4 0.2 -1.2
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.5 -0.1
Commuting to job workplace: Cycle 0.0 0.0 0.0 -0.2 0.1
Myopia 1.1 1.6 1.7 -1.2 1.3
Vascular/heart problems diagnosed by doctor 4.1 11.1 22.1 -0.3 -4.7
Cholesterol lowering medication 4.7 7.0 9.8 2.0 3.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.7 0.0 1.3
Pain experienced in last month 1.4 2.3 4.3 -0.6 2.1
Supplements: Calcium 0.6 0.6 1.1 -0.4 1.0
Basal cell carcinoma (self-reported) 3.1 3.7 4.3 2.1 -1.8
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.5 -0.6 1.2
Deep venous thrombosis (DVT) (self-reported) 2.5 3.2 6.4 -0.2 -2.5
Heart disease (siblings) 0.0 0.1 0.1 -0.3 0.1
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.2 -0.5
Pack years of smoking 0.6 0.8 1.6 1.3 0.1
Impedance of whole body 2.1 10.7 21.3 -4.6 0.1
Leg fat mass (left) 1.0 4.0 7.7 2.8 -0.5
Arm predicted mass (left) 0.2 0.8 1.5 1.2 -0.3