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chr10:103,527,782-105,275,242

Best TWAS P=1.67e-11 · Best GWAS P=1.78e-10 conditioned to 0.535

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-6.2	6.7	1.7e-11	-0.91	0.03	0.97	TRUE
6	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-6.3	-6.7	2.2e-11	0.93	0.02	0.96	FALSE
38	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	-6.2	6.6	3.4e-11	-0.82	0.04	0.95	FALSE
10	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	-6.4	-6.6	5.2e-11	0.99	0.03	0.97	FALSE
21	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-6.2	-6.5	6.5e-11	0.76	0.05	0.91	FALSE
12	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	-6.2	-6.5	8.7e-11	0.99	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-5.7	-6.5	9.3e-11	0.84	0.04	0.64	FALSE
17	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	-6.4	-6.5	9.4e-11	1.00	0.02	0.98	FALSE
39	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-6.4	6.5	1.0e-10	-0.81	0.03	0.97	FALSE
4	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	-6.4	6.5	1.1e-10	-0.83	0.04	0.67	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	-6.3	6.4	1.4e-10	-1.00	0.02	0.81	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	-6.4	-6.4	1.5e-10	0.98	0.01	0.93	FALSE
7	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	-6.4	-6.4	1.9e-10	0.94	0.03	0.89	FALSE
14	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-6.3	-6.4	2.0e-10	0.80	0.05	0.85	FALSE
9	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	-6.3	-6.2	4.8e-10	0.97	0.03	0.96	FALSE
22	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	-6.2	-6.2	6.0e-10	0.97	0.03	0.97	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	-6.2	-6.2	6.1e-10	0.97	0.04	0.96	FALSE
26	GTEx	Nerve Tibial	TMEM180	0.32	0.30	enet	16	0.32	2.0e-23	-6.3	-6.2	6.8e-10	0.99	0.02	0.98	FALSE
18	GTEx	Colon Transverse	TMEM180	0.16	0.15	enet	11	0.13	1.2e-06	-6.3	-6.2	7.4e-10	0.99	0.02	0.98	FALSE
11	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	-6.2	-6.1	7.8e-10	0.95	0.03	0.91	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-5.9	-6.0	1.7e-09	0.75	0.11	0.89	FALSE
8	GTEx	Artery Tibial	TMEM180	0.07	0.05	enet	14	0.03	3.8e-03	-6.3	-6.0	2.6e-09	0.97	0.02	0.98	FALSE
28	GTEx	Pituitary	TMEM180	0.36	0.23	enet	12	0.20	1.1e-05	-6.4	-5.9	2.7e-09	0.96	0.02	0.96	FALSE
36	METSIM	Adipose	TMEM180	0.28	0.25	enet	33	0.26	2.5e-39	-6.2	-5.9	3.1e-09	0.95	0.03	0.97	FALSE
31	GTEx	Stomach	TMEM180	0.33	0.22	lasso	8	0.21	2.2e-10	-6.4	-5.9	3.7e-09	0.99	0.02	0.98	FALSE
30	GTEx	Spleen	TMEM180	0.16	0.21	lasso	3	0.05	2.6e-02	-6.2	-5.9	3.8e-09	0.95	0.03	0.86	FALSE
24	GTEx	Heart Left Ventricle	TMEM180	0.19	0.17	enet	14	0.17	3.7e-09	-6.4	-5.8	5.1e-09	0.96	0.02	0.98	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	TMEM180	0.22	0.23	enet	11	0.27	3.0e-10	-6.2	-5.8	5.7e-09	0.93	0.02	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARL3	0.03	0.03	lasso	6	0.03	1.8e-04	-4.8	5.8	6.5e-09	-0.82	0.03	0.96	FALSE
29	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-5.8	5.8	8.0e-09	-0.69	0.34	0.65	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-5.8	5.7	9.8e-09	-0.68	0.14	0.42	FALSE
16	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-5.7	5.7	9.8e-09	-0.69	0.19	0.40	FALSE
20	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-5.0	-5.6	2.1e-08	0.70	0.05	0.93	FALSE
32	GTEx	Testis	TMEM180	0.19	0.05	enet	24	0.12	7.9e-06	-6.3	-5.6	2.1e-08	0.75	0.04	0.95	FALSE
35	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	-6.4	-5.6	2.4e-08	0.69	0.04	0.48	FALSE
13	GTEx	Breast Mammary Tissue (Male)	TMEM180	0.26	0.15	lasso	17	0.17	1.0e-04	-6.4	-5.5	2.9e-08	0.95	0.03	0.91	FALSE
25	GTEx	Lung	TMEM180	0.12	0.11	lasso	4	0.13	5.1e-10	-6.4	-5.5	2.9e-08	0.94	0.02	0.98	FALSE
34	GTEx	Thyroid	TMEM180	0.31	0.38	enet	20	0.42	8.1e-35	-6.4	-5.5	3.1e-08	0.96	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	-5.8	5.5	3.2e-08	-0.79	0.06	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	4.6	5.5	3.4e-08	-0.64	0.11	0.44	FALSE
23	GTEx	Heart Atrial Appendage	TMEM180	0.42	0.21	enet	35	0.27	2.1e-12	-6.4	-5.5	4.5e-08	0.76	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	TMEM180	0.24	0.16	enet	11	0.18	2.2e-14	-6.3	-5.5	4.6e-08	0.94	0.02	0.98	FALSE
33	GTEx	Thyroid	C10orf95	0.10	0.02	enet	28	0.02	6.6e-03	-6.4	-5.4	8.2e-08	0.74	0.02	0.89	FALSE
27	GTEx	Ovary	TMEM180	0.41	0.24	enet	18	0.23	2.4e-06	-6.3	-5.3	1.3e-07	0.89	0.02	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	WBP1L	0.08	0.00	enet	13	0.01	8.1e-02	4.6	5.3	1.4e-07	-0.66	0.06	0.57	FALSE