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chr2:101,994,731-103,767,612

Best TWAS P=4.36e-61 · Best GWAS P=1.75e-54 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL1RL1	0.08	0.08	enet	9	0.08	1.2e-09	-15.52	-16.5	4.4e-61	0.95	0.00	1.00	TRUE
21	The Cancer Genome Atlas	Thyroid Carcinoma	IL1RL1	0.05	0.03	enet	6	0.03	9.7e-04	-15.52	-15.8	1.8e-56	0.98	0.00	0.99	TRUE
7	ROSMAP	Brain Pre-frontal Cortex	IL1RL2	0.08	0.02	enet	33	0.03	2.3e-04	6.36	-10.7	1.6e-26	0.48	0.17	0.17	TRUE
8	YFS	Blood	IL18RAP	0.41	0.55	bslmm	562	0.62	4.2e-269	9.26	-6.9	4.7e-12	0.32	1.00	0.00	TRUE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL1RL1	0.04	0.04	lasso	8	0.04	1.7e-05	-15.32	-16.2	6.7e-59	0.91	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	IL1RL1	0.03	0.01	blup	78	0.02	4.7e-03	-15.28	-16.0	2.7e-57	0.84	0.01	0.94	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IL1RL1	0.18	0.06	blup	78	0.15	3.7e-09	10.55	-15.4	1.1e-53	0.83	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IL1RL1	0.19	0.05	blup	78	0.10	7.1e-05	10.64	-14.4	5.5e-47	0.62	0.11	0.72	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL1RL1	0.02	0.01	blup	78	0.01	1.5e-03	10.55	-13.2	7.1e-40	0.63	0.16	0.22	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL18RAP	0.03	0.02	blup	94	0.02	1.2e-03	-12.24	13.0	6.7e-39	-0.61	0.02	0.75	FALSE
9	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL1RL1	0.04	0.03	lasso	7	0.03	8.1e-04	-12.22	-12.6	2.5e-36	0.50	0.24	0.12	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL1RL2	0.04	0.04	enet	5	0.03	1.9e-04	-11.98	-12.4	4.1e-35	0.70	0.06	0.41	FALSE
3	GTEx	Colon Transverse	IL18R1	0.14	0.00	enet	41	0.00	2.1e-01	2.67	9.7	2.0e-22	-0.40	0.04	0.48	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	IL1R1	0.36	0.19	enet	28	0.23	1.1e-23	-11.45	9.1	1.0e-19	-0.51	0.10	0.90	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL18R1	0.06	0.01	blup	108	0.04	2.6e-05	-0.41	-7.5	6.6e-14	0.63	0.01	0.86	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL18R1	0.05	0.01	blup	108	0.03	1.8e-07	-12.24	7.3	3.8e-13	-0.08	0.99	0.00	FALSE
4	GTEx	Whole Blood	IL18R1	0.06	0.00	enet	14	0.01	2.1e-02	-12.22	6.8	8.1e-12	-0.24	0.17	0.04	FALSE
5	NTR	Blood	IL18R1	0.05	0.02	bslmm	582	0.02	5.1e-07	4.63	6.3	3.9e-10	-0.29	0.99	0.00	FALSE
6	NTR	Blood	IL18RAP	0.14	0.16	lasso	7	0.19	1.1e-59	9.26	-6.0	2.6e-09	0.26	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	IL1R1	0.14	0.09	lasso	3	0.10	4.0e-12	-5.54	5.7	1.2e-08	-0.15	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IL1RL2	0.18	0.05	bslmm	549	0.09	1.8e-11	-9.52	-5.4	7.9e-08	0.26	1.00	0.00	FALSE